HLA-DRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.67070603
2B cell mediated immunity (GO:0019724)5.25885983
3antigen processing and presentation of endogenous antigen (GO:0019883)5.17947768
4regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.97413523
5positive regulation of gamma-delta T cell activation (GO:0046645)4.91635228
6* interferon-gamma-mediated signaling pathway (GO:0060333)4.78369846
7regulation of antigen processing and presentation (GO:0002577)4.78355093
8positive regulation of antigen processing and presentation (GO:0002579)4.60093329
9regulation of dendritic cell antigen processing and presentation (GO:0002604)4.59935849
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43111035
11detection of bacterium (GO:0016045)4.43017211
12T-helper 1 type immune response (GO:0042088)4.42694162
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34540995
14detection of other organism (GO:0098543)4.33679182
15response to peptidoglycan (GO:0032494)4.22190932
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18184054
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04468051
18negative regulation of cell killing (GO:0031342)4.04468051
19modulation by symbiont of host immune response (GO:0052553)4.03783166
20positive regulation by symbiont of host defense response (GO:0052509)4.03783166
21modulation by symbiont of host defense response (GO:0052031)4.03783166
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.03783166
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.03783166
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.03783166
25positive thymic T cell selection (GO:0045059)4.02012470
26regulation of B cell receptor signaling pathway (GO:0050855)3.90289013
27neutrophil activation involved in immune response (GO:0002283)3.89844600
28cellular response to type I interferon (GO:0071357)3.89042630
29type I interferon signaling pathway (GO:0060337)3.89042630
30response to type I interferon (GO:0034340)3.85437772
31negative regulation of interleukin-12 production (GO:0032695)3.80538433
32* cellular response to interferon-gamma (GO:0071346)3.75339754
33macrophage activation involved in immune response (GO:0002281)3.72051404
34B cell receptor signaling pathway (GO:0050853)3.65656792
35negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.62529903
36defense response to protozoan (GO:0042832)3.56324043
37positive regulation of type 2 immune response (GO:0002830)3.52093752
38response to protozoan (GO:0001562)3.51815601
39positive regulation of B cell differentiation (GO:0045579)3.49885394
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44638354
41regulation of gamma-delta T cell activation (GO:0046643)3.43420657
42NIK/NF-kappaB signaling (GO:0038061)3.43418112
43detection of external biotic stimulus (GO:0098581)3.42445014
44* response to interferon-gamma (GO:0034341)3.41399622
45myeloid dendritic cell activation (GO:0001773)3.38328238
46regulation of interferon-beta biosynthetic process (GO:0045357)3.36672093
47regulation of T-helper 1 cell differentiation (GO:0045625)3.36202916
48* T cell costimulation (GO:0031295)3.33099912
49regulation of interferon-alpha production (GO:0032647)3.30099266
50myeloid dendritic cell differentiation (GO:0043011)3.28413393
51* lymphocyte costimulation (GO:0031294)3.28003121
52negative thymic T cell selection (GO:0045060)3.26845257
53positive regulation of interferon-alpha production (GO:0032727)3.21727464
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20319898
55positive regulation of macrophage cytokine production (GO:0060907)3.14005130
56production of molecular mediator of immune response (GO:0002440)3.12749851
57germinal center formation (GO:0002467)3.11336838
58regulation of mast cell degranulation (GO:0043304)3.08672814
59myeloid cell activation involved in immune response (GO:0002275)3.07211486
60adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.07131578
61response to host immune response (GO:0052572)3.04666804
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04666804
63response to muramyl dipeptide (GO:0032495)3.04444296
64positive regulation of mast cell activation (GO:0033005)3.01599927
65lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01395598
66detection of biotic stimulus (GO:0009595)3.01339300
67T cell migration (GO:0072678)2.99559355
68negative T cell selection (GO:0043383)2.99475844
69regulation of mast cell activation (GO:0033003)2.97769160
70positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.97673019
71regulation of alpha-beta T cell proliferation (GO:0046640)2.96873093
72regulation of inflammatory response to antigenic stimulus (GO:0002861)2.91466905
73regulation of mast cell activation involved in immune response (GO:0033006)2.91064412
74positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91035971
75respiratory burst (GO:0045730)2.90667790
76chaperone mediated protein folding requiring cofactor (GO:0051085)2.89357345
77mature B cell differentiation involved in immune response (GO:0002313)2.89030438
78positive T cell selection (GO:0043368)2.87487484
79regulation of B cell differentiation (GO:0045577)2.87054634
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85108215
81regulation of type 2 immune response (GO:0002828)2.83001951
82cellular extravasation (GO:0045123)2.81977486
83positive regulation of mast cell degranulation (GO:0043306)2.77922389
84positive regulation of mast cell activation involved in immune response (GO:0033008)2.77922389
85regulation of gamma-delta T cell differentiation (GO:0045586)2.77715068
86regulation of T cell tolerance induction (GO:0002664)2.77285901
87response to host (GO:0075136)2.77217019
88response to host defenses (GO:0052200)2.77217019
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77217019
90regulation of interleukin-12 production (GO:0032655)2.75756532
91thymic T cell selection (GO:0045061)2.74742569
92microglial cell activation (GO:0001774)2.74600131
93regulation of germinal center formation (GO:0002634)2.74535045
94regulation of hypersensitivity (GO:0002883)2.73950408
95adaptive immune response (GO:0002250)2.73586517
96negative regulation of cytokine production involved in immune response (GO:0002719)2.73129052
97positive regulation of neutrophil chemotaxis (GO:0090023)2.72498069
98positive regulation of neutrophil migration (GO:1902624)2.72498069
99granulocyte activation (GO:0036230)2.72341700
100positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.71438884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.47843145
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.52173337
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.70503349
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.07133107
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53056219
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.25595540
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13697659
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10956576
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99011452
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96677444
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.81787243
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65752421
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65204139
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59213047
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58924701
16VDR_21846776_ChIP-Seq_THP-1_Human2.57110979
17VDR_24763502_ChIP-Seq_THP-1_Human2.44613606
18SPI1_23547873_ChIP-Seq_NB4_Human2.41863187
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31150221
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25846708
21MYC_22102868_ChIP-Seq_BL_Human2.25217125
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25090891
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23404329
24SCL_19346495_ChIP-Seq_HPC-7_Human2.22450847
25MYB_26560356_Chip-Seq_TH2_Human2.18677417
26MAF_26560356_Chip-Seq_TH1_Human2.05268868
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00094277
28SPI1_23127762_ChIP-Seq_K562_Human1.98552018
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98167859
30RUNX_20019798_ChIP-Seq_JUKART_Human1.97238517
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96455972
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.87819511
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.82143767
34MYB_26560356_Chip-Seq_TH1_Human1.79236566
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76312260
36UTX_26944678_Chip-Seq_JUKART_Human1.69634450
37VDR_24787735_ChIP-Seq_THP-1_Human1.66315913
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66128016
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64847864
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63766927
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63213732
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59321755
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58324475
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58057380
45GATA3_27048872_Chip-Seq_THYMUS_Human1.45449537
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45114028
47CIITA_25753668_ChIP-Seq_RAJI_Human1.44592852
48MAF_26560356_Chip-Seq_TH2_Human1.44509309
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44073258
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41234468
51LXR_22292898_ChIP-Seq_THP-1_Human1.40428458
52GATA1_22025678_ChIP-Seq_K562_Human1.40173248
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37437942
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36031180
55BCL6_27268052_Chip-Seq_Bcells_Human1.35803350
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33113301
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33005185
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28118891
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26292778
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24476208
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24473420
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24390949
63TCF7_22412390_ChIP-Seq_EML_Mouse1.24028824
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23199287
65GATA3_26560356_Chip-Seq_TH2_Human1.21130864
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20562745
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.20130570
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19155655
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18774475
70BCOR_27268052_Chip-Seq_Bcells_Human1.17396685
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14919458
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14809608
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14550683
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14074428
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14061415
76PU_27001747_Chip-Seq_BMDM_Mouse1.12568187
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11237026
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.10304786
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.08788275
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07094207
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06017586
82GATA1_19941826_ChIP-Seq_K562_Human1.02855380
83STAT1_20625510_ChIP-Seq_HELA_Human1.02504200
84KDM2B_26808549_Chip-Seq_DND41_Human1.02049002
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99355260
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99196068
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98093719
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91710935
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90501644
90CTCF_26484167_Chip-Seq_Bcells_Mouse0.87026292
91P300_27268052_Chip-Seq_Bcells_Human0.86708582
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86399992
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85948896
94SPI1_20517297_ChIP-Seq_HL60_Human0.85637053
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85428955
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.81721141
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81195283
98TFEB_21752829_ChIP-Seq_HELA_Human0.78787861
99NCOR1_26117541_ChIP-Seq_K562_Human0.78106880
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77755611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.52195941
2MP0003303_peritoneal_inflammation3.92845805
3MP0005671_abnormal_response_to3.78663936
4MP0003436_decreased_susceptibility_to3.46774933
5MP0001790_abnormal_immune_system3.30242442
6MP0005387_immune_system_phenotype3.30242442
7MP0000685_abnormal_immune_system3.24164218
8MP0003724_increased_susceptibility_to3.22654725
9MP0002148_abnormal_hypersensitivity_rea3.21899396
10MP0005000_abnormal_immune_tolerance3.13302578
11MP0001800_abnormal_humoral_immune3.08836061
12MP0009785_altered_susceptibility_to2.96035330
13MP0005025_abnormal_response_to2.81893358
14MP0002452_abnormal_antigen_presenting2.73129660
15MP0002419_abnormal_innate_immunity2.72682090
16MP0006082_CNS_inflammation2.68140504
17MP0002723_abnormal_immune_serum2.64329225
18MP0002420_abnormal_adaptive_immunity2.42924395
19MP0005058_abnormal_lysosome_morphology2.42766850
20MP0001819_abnormal_immune_cell2.40856735
21MP0002138_abnormal_hepatobiliary_system2.20765532
22MP0010155_abnormal_intestine_physiology2.19003774
23MP0002139_abnormal_hepatobiliary_system2.01734780
24MP0001845_abnormal_inflammatory_respons1.91103490
25MP0003300_gastrointestinal_ulcer1.86634173
26MP0005464_abnormal_platelet_physiology1.85499628
27MP0000716_abnormal_immune_system1.83230356
28MP0003806_abnormal_nucleotide_metabolis1.82233035
29MP0001533_abnormal_skeleton_physiology1.80690067
30MP0009764_decreased_sensitivity_to1.77902729
31MP0002398_abnormal_bone_marrow1.76231176
32MP0003763_abnormal_thymus_physiology1.75985403
33MP0002405_respiratory_system_inflammati1.74594309
34MP0003075_altered_response_to1.73132287
35MP0009333_abnormal_splenocyte_physiolog1.71887828
36MP0004947_skin_inflammation1.68982067
37MP0003172_abnormal_lysosome_physiology1.66372645
38MP0009278_abnormal_bone_marrow1.63335569
39MP0003191_abnormal_cellular_cholesterol1.60973192
40MP0008469_abnormal_protein_level1.58140299
41MP0003183_abnormal_peptide_metabolism1.56783982
42MP0009840_abnormal_foam_cell1.54452526
43MP0001853_heart_inflammation1.53627664
44MP0000343_altered_response_to1.49572027
45MP0000689_abnormal_spleen_morphology1.49035818
46MP0005166_decreased_susceptibility_to1.48389324
47MP0005451_abnormal_body_composition1.48379604
48MP0002429_abnormal_blood_cell1.46658374
49MP0002166_altered_tumor_susceptibility1.45711206
50MP0005397_hematopoietic_system_phenotyp1.44985800
51MP0001545_abnormal_hematopoietic_system1.44985800
52MP0001873_stomach_inflammation1.39698297
53MP0005310_abnormal_salivary_gland1.37573524
54MP0004510_myositis1.35887706
55MP0000465_gastrointestinal_hemorrhage1.35123753
56MP0002722_abnormal_immune_system1.34308067
57MP0002998_abnormal_bone_remodeling1.25518266
58MP0000604_amyloidosis1.25284688
59MP0000858_altered_metastatic_potential1.23510184
60MP0003866_abnormal_defecation1.18960592
61MP0008004_abnormal_stomach_pH1.13418883
62MP0002006_tumorigenesis1.09749486
63MP0003448_altered_tumor_morphology1.02761649
64MP0001663_abnormal_digestive_system0.99687267
65MP0009763_increased_sensitivity_to0.94884872
66MP0005167_abnormal_blood-brain_barrier0.86575242
67MP0008260_abnormal_autophagy0.86225779
68MP0000703_abnormal_thymus_morphology0.82312350
69MP0000490_abnormal_crypts_of0.81230455
70MP0000249_abnormal_blood_vessel0.80819527
71MP0005165_increased_susceptibility_to0.79478093
72MP0002933_joint_inflammation0.78042348
73MP0001851_eye_inflammation0.76943134
74MP0003828_pulmonary_edema0.74948457
75MP0005390_skeleton_phenotype0.73559491
76MP0003690_abnormal_glial_cell0.72319764
77MP0009765_abnormal_xenobiotic_induced0.69937142
78MP0002396_abnormal_hematopoietic_system0.69207783
79MP0008874_decreased_physiological_sensi0.66591925
80MP0004883_abnormal_blood_vessel0.65189718
81MP0005164_abnormal_response_to0.64746457
82MP0005075_abnormal_melanosome_morpholog0.63866741
83MP0002254_reproductive_system_inflammat0.62385770
84MP0003045_fibrosis0.61736725
85MP0009643_abnormal_urine_homeostasis0.61289022
86MP0002136_abnormal_kidney_physiology0.59852007
87MP0004808_abnormal_hematopoietic_stem0.59538792
88MP0005360_urolithiasis0.59196604
89MP0003795_abnormal_bone_structure0.57935622
90MP0005319_abnormal_enzyme/_coenzyme0.57670253
91MP0005381_digestive/alimentary_phenotyp0.57443976
92MP0005535_abnormal_body_temperature0.56926060
93MP0000920_abnormal_myelination0.56138597
94MP0002019_abnormal_tumor_incidence0.55402474
95MP0003453_abnormal_keratinocyte_physiol0.55400595
96MP0000609_abnormal_liver_physiology0.54899357
97MP0005584_abnormal_enzyme/coenzyme_acti0.54682814
98MP0002132_abnormal_respiratory_system0.53421529
99MP0005365_abnormal_bile_salt0.52665077
100MP0003656_abnormal_erythrocyte_physiolo0.52469598

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.91303009
2Recurrent bacterial skin infections (HP:0005406)4.77611113
3Abnormality of macrophages (HP:0004311)4.70232805
4Recurrent abscess formation (HP:0002722)4.54302933
5Abnormality of liposaccharide metabolism (HP:0010968)4.51988307
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.51988307
7Abnormality of glycolipid metabolism (HP:0010969)4.51988307
8Mediastinal lymphadenopathy (HP:0100721)4.46212405
9Meningitis (HP:0001287)4.31114729
10Agammaglobulinemia (HP:0004432)4.18011254
11Systemic lupus erythematosus (HP:0002725)4.17513591
12Vasculitis (HP:0002633)3.90141621
13Obstructive lung disease (HP:0006536)3.85735299
14Chronic obstructive pulmonary disease (HP:0006510)3.85735299
15Gastrointestinal stroma tumor (HP:0100723)3.78576932
16Myositis (HP:0100614)3.73537216
17Recurrent gram-negative bacterial infections (HP:0005420)3.66301328
18Recurrent fungal infections (HP:0002841)3.64005549
19Elevated erythrocyte sedimentation rate (HP:0003565)3.63647110
20Pulmonary infiltrates (HP:0002113)3.60174313
21Vacuolated lymphocytes (HP:0001922)3.53267999
22Orchitis (HP:0100796)3.46295032
23Urticaria (HP:0001025)3.40693496
24Increased cerebral lipofuscin (HP:0011813)3.37683327
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.37162040
26Retrobulbar optic neuritis (HP:0100654)3.36939020
27Optic neuritis (HP:0100653)3.36939020
28Recurrent skin infections (HP:0001581)3.36880122
29Recurrent viral infections (HP:0004429)3.33824748
30Recurrent cutaneous fungal infections (HP:0011370)3.32915932
31Chronic mucocutaneous candidiasis (HP:0002728)3.32915932
32Cellulitis (HP:0100658)3.29284585
33Autoimmune thrombocytopenia (HP:0001973)3.11846601
34Abnormality of the prostate (HP:0008775)3.07619024
35Hemoptysis (HP:0002105)3.02972485
36Stomatitis (HP:0010280)3.02352074
37Colitis (HP:0002583)3.01975246
38Recurrent sinusitis (HP:0011108)2.99534019
39Recurrent bronchitis (HP:0002837)2.97149285
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.92069816
41Panhypogammaglobulinemia (HP:0003139)2.89694901
42Dysostosis multiplex (HP:0000943)2.89267710
43Encephalitis (HP:0002383)2.87872967
44Increased IgM level (HP:0003496)2.83503309
45Restrictive lung disease (HP:0002091)2.79234841
46Increased IgE level (HP:0003212)2.78699400
47Loss of speech (HP:0002371)2.75737401
48Spontaneous hematomas (HP:0007420)2.73437111
49Inflammation of the large intestine (HP:0002037)2.70726872
50Abnormality of the pleura (HP:0002103)2.69045608
51Lymphopenia (HP:0001888)2.66778090
52Chest pain (HP:0100749)2.66744987
53Chronic diarrhea (HP:0002028)2.65747417
54Petechiae (HP:0000967)2.64490248
55Recurrent pneumonia (HP:0006532)2.63640430
56Gastrointestinal inflammation (HP:0004386)2.63123499
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.55915004
58Gastrointestinal infarctions (HP:0005244)2.54716958
59Osteomyelitis (HP:0002754)2.53674190
60Abnormality of B cell number (HP:0010975)2.52186324
61Purpura (HP:0000979)2.50159572
62IgM deficiency (HP:0002850)2.46684527
63Hypertensive crisis (HP:0100735)2.45042317
64Recurrent lower respiratory tract infections (HP:0002783)2.44460331
65Gangrene (HP:0100758)2.44218142
66Abnormality of T cells (HP:0002843)2.43852983
67Keratoconjunctivitis sicca (HP:0001097)2.43286787
68Abnormality of T cell number (HP:0011839)2.43014803
69Pulmonary fibrosis (HP:0002206)2.42552824
70Skin rash (HP:0000988)2.41894476
71Hypergammaglobulinemia (HP:0010702)2.41436916
72IgA deficiency (HP:0002720)2.40841563
73Gingivitis (HP:0000230)2.39782958
74Emphysema (HP:0002097)2.38401825
75T lymphocytopenia (HP:0005403)2.37156190
76IgG deficiency (HP:0004315)2.36774904
77Pustule (HP:0200039)2.34677231
78Abnormality of T cell physiology (HP:0011840)2.30177616
79Autoimmune hemolytic anemia (HP:0001890)2.29217623
80Pulmonary embolism (HP:0002204)2.28332011
81Keratoconjunctivitis (HP:0001096)2.26887150
82Xerostomia (HP:0000217)2.26744161
83Chronic otitis media (HP:0000389)2.25045535
84Arthralgia (HP:0002829)2.21946551
85Hepatosplenomegaly (HP:0001433)2.20694647
86Glomerulonephritis (HP:0000099)2.19545939
87B lymphocytopenia (HP:0010976)2.19456997
88Sepsis (HP:0100806)2.19276434
89Disinhibition (HP:0000734)2.19213532
90Epistaxis (HP:0000421)2.19146510
91Polyneuropathy (HP:0001271)2.19062444
92Premature loss of primary teeth (HP:0006323)2.15605145
93Leukocytosis (HP:0001974)2.12957303
94Increased serum ferritin (HP:0003281)2.11682236
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09443837
96Abnormality of polysaccharide metabolism (HP:0011012)2.09443837
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09443837
98Amyloidosis (HP:0011034)2.05638016
99Skin ulcer (HP:0200042)2.05313361
100Granulocytopenia (HP:0001913)2.04913924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.47465268
2RIPK44.26964207
3BLK3.20322503
4ERN12.97703166
5TBK12.72844874
6KIT2.70816981
7TYK22.68464686
8MAP3K142.65877393
9IRAK42.31695803
10CSF1R2.30098706
11SYK2.29936676
12IKBKE2.19891982
13JAK32.14569997
14BMPR22.12847530
15NME22.00329233
16PRPF4B1.99071198
17MATK1.95503511
18IKBKB1.94688716
19TXK1.90528061
20CSK1.89926697
21FES1.83876416
22MAP3K131.72484955
23BTK1.70762143
24TAOK31.69881436
25LYN1.67187996
26TESK21.59185190
27IRAK31.52516614
28MAP2K31.51853074
29MAP3K111.49370734
30GRK71.47487657
31TLK11.42720219
32ZAP701.40367855
33FGR1.37525976
34JAK11.36572472
35KDR1.18707836
36LCK1.16548083
37HCK1.15836473
38TNK21.10820527
39ITK1.10296500
40TEC1.09483068
41GRK61.08960636
42TAOK21.07964326
43BCKDK1.07864285
44CDK191.07647806
45MAP3K31.07006980
46SIK31.05724747
47DDR21.04105587
48CDC42BPA1.02630497
49JAK20.96605150
50PIM20.93309852
51ACVR1B0.87271398
52PRKCQ0.84107646
53MAP3K10.81456959
54MARK30.77550050
55SIK20.77057263
56CHUK0.76030135
57PIM10.74435357
58TGFBR20.72690244
59MAPK70.72119013
60ADRBK20.68168305
61PDK10.65894264
62TAOK10.64013975
63ARAF0.62872566
64NEK90.61130667
65MAPK120.58927169
66MOS0.55024211
67DAPK30.54894584
68STK100.52989233
69SMG10.51913226
70HIPK20.48926028
71PDPK10.48286773
72ABL10.48265983
73IRAK10.46920238
74MAP2K60.46526301
75FGFR40.45030476
76CDK40.44860904
77MAP3K50.44384169
78MAPK110.43730989
79FYN0.42934026
80MAPK40.42638711
81PIK3CG0.42078366
82PRKCD0.41741021
83RIPK10.38907496
84ABL20.38592373
85MAPKAPK20.37010577
86RPS6KL10.36434526
87RPS6KC10.36434526
88CCNB10.34224806
89RPS6KA50.32961008
90DAPK20.30436802
91CDK60.30161501
92RPS6KA60.30079144
93FGFR30.27674843
94MAP2K20.26248734
95DAPK10.26052846
96IRAK20.25785350
97INSR0.25351695
98EPHB10.24369807
99SCYL20.24303190
100EGFR0.24228051

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053104.81758666
2* Allograft rejection_Homo sapiens_hsa053304.69998182
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.29782511
4* Graft-versus-host disease_Homo sapiens_hsa053324.29262264
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.13251324
6* Type I diabetes mellitus_Homo sapiens_hsa049403.58595617
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.46883040
8* Leishmaniasis_Homo sapiens_hsa051403.10164741
9* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.83565750
10* Antigen processing and presentation_Homo sapiens_hsa046122.83349092
11* Viral myocarditis_Homo sapiens_hsa054162.58885597
12* Rheumatoid arthritis_Homo sapiens_hsa053232.43048835
13Primary immunodeficiency_Homo sapiens_hsa053402.35783695
14* Tuberculosis_Homo sapiens_hsa051521.95176710
15Osteoclast differentiation_Homo sapiens_hsa043801.78725636
16Other glycan degradation_Homo sapiens_hsa005111.73505525
17* Hematopoietic cell lineage_Homo sapiens_hsa046401.72748568
18* Systemic lupus erythematosus_Homo sapiens_hsa053221.69453315
19B cell receptor signaling pathway_Homo sapiens_hsa046621.67669423
20* Toxoplasmosis_Homo sapiens_hsa051451.67243163
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65048115
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.64667984
23* Influenza A_Homo sapiens_hsa051641.59110263
24* Herpes simplex infection_Homo sapiens_hsa051681.52240092
25* Phagosome_Homo sapiens_hsa041451.36385099
26Lysosome_Homo sapiens_hsa041421.30131487
27Pertussis_Homo sapiens_hsa051331.20131696
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14479087
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13400060
30* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11293743
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09257406
32Malaria_Homo sapiens_hsa051441.03225488
33Measles_Homo sapiens_hsa051621.02538130
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00264225
35Legionellosis_Homo sapiens_hsa051340.99539331
36TNF signaling pathway_Homo sapiens_hsa046680.95547190
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88047540
38Chemokine signaling pathway_Homo sapiens_hsa040620.84039487
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82735376
40African trypanosomiasis_Homo sapiens_hsa051430.82004012
41Salmonella infection_Homo sapiens_hsa051320.80157588
42* Epstein-Barr virus infection_Homo sapiens_hsa051690.79557082
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.75049946
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73125643
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.71858995
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70993502
47T cell receptor signaling pathway_Homo sapiens_hsa046600.67963321
48Hepatitis C_Homo sapiens_hsa051600.64617140
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64085143
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59525295
51Shigellosis_Homo sapiens_hsa051310.59164659
52Apoptosis_Homo sapiens_hsa042100.55505282
53Hepatitis B_Homo sapiens_hsa051610.55244442
54* HTLV-I infection_Homo sapiens_hsa051660.52200132
55Acute myeloid leukemia_Homo sapiens_hsa052210.50632411
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45515836
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.45458042
58Platelet activation_Homo sapiens_hsa046110.41651918
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41238404
60Viral carcinogenesis_Homo sapiens_hsa052030.39669195
61Renin-angiotensin system_Homo sapiens_hsa046140.34512059
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33311083
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31445794
64Arachidonic acid metabolism_Homo sapiens_hsa005900.27889376
65Collecting duct acid secretion_Homo sapiens_hsa049660.27100205
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26745004
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26555072
68Prolactin signaling pathway_Homo sapiens_hsa049170.23953234
69Galactose metabolism_Homo sapiens_hsa000520.21252754
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.20501678
71Fructose and mannose metabolism_Homo sapiens_hsa000510.20280273
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.19357216
73Complement and coagulation cascades_Homo sapiens_hsa046100.18367554
74Amoebiasis_Homo sapiens_hsa051460.18035373
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18006868
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16155955
77Vitamin digestion and absorption_Homo sapiens_hsa049770.14541380
78VEGF signaling pathway_Homo sapiens_hsa043700.14142805
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14093598
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.13840888
81Sulfur metabolism_Homo sapiens_hsa009200.13619655
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12215088
83Endocytosis_Homo sapiens_hsa041440.11327898
84Pentose phosphate pathway_Homo sapiens_hsa000300.10892849
85PPAR signaling pathway_Homo sapiens_hsa033200.10829510
86Ether lipid metabolism_Homo sapiens_hsa005650.10727972
87Prion diseases_Homo sapiens_hsa050200.10292689
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.10242897
89Alcoholism_Homo sapiens_hsa050340.07362874
90Bladder cancer_Homo sapiens_hsa052190.06858343
91HIF-1 signaling pathway_Homo sapiens_hsa040660.06387746
92Tryptophan metabolism_Homo sapiens_hsa003800.06348655
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05520020
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.05449930
95Pancreatic cancer_Homo sapiens_hsa052120.04911590
96Sphingolipid metabolism_Homo sapiens_hsa006000.04486149
97Mineral absorption_Homo sapiens_hsa049780.04401733
98Linoleic acid metabolism_Homo sapiens_hsa005910.00884729
99Insulin resistance_Homo sapiens_hsa049310.00051519
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0069805

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