Rank | Gene Set | Z-score |
---|---|---|
1 | immunoglobulin mediated immune response (GO:0016064) | 6.67070603 |
2 | B cell mediated immunity (GO:0019724) | 5.25885983 |
3 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.17947768 |
4 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 4.97413523 |
5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.91635228 |
6 | * interferon-gamma-mediated signaling pathway (GO:0060333) | 4.78369846 |
7 | regulation of antigen processing and presentation (GO:0002577) | 4.78355093 |
8 | positive regulation of antigen processing and presentation (GO:0002579) | 4.60093329 |
9 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.59935849 |
10 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.43111035 |
11 | detection of bacterium (GO:0016045) | 4.43017211 |
12 | T-helper 1 type immune response (GO:0042088) | 4.42694162 |
13 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.34540995 |
14 | detection of other organism (GO:0098543) | 4.33679182 |
15 | response to peptidoglycan (GO:0032494) | 4.22190932 |
16 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.18184054 |
17 | negative regulation of cell killing (GO:0031342) | 4.04468051 |
18 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.04468051 |
19 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.03783166 |
20 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.03783166 |
21 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.03783166 |
22 | modulation by symbiont of host immune response (GO:0052553) | 4.03783166 |
23 | positive regulation by symbiont of host defense response (GO:0052509) | 4.03783166 |
24 | modulation by symbiont of host defense response (GO:0052031) | 4.03783166 |
25 | positive thymic T cell selection (GO:0045059) | 4.02012470 |
26 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.90289013 |
27 | neutrophil activation involved in immune response (GO:0002283) | 3.89844600 |
28 | type I interferon signaling pathway (GO:0060337) | 3.89042630 |
29 | cellular response to type I interferon (GO:0071357) | 3.89042630 |
30 | response to type I interferon (GO:0034340) | 3.85437772 |
31 | negative regulation of interleukin-12 production (GO:0032695) | 3.80538433 |
32 | * cellular response to interferon-gamma (GO:0071346) | 3.75339754 |
33 | macrophage activation involved in immune response (GO:0002281) | 3.72051404 |
34 | B cell receptor signaling pathway (GO:0050853) | 3.65656792 |
35 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.62529903 |
36 | defense response to protozoan (GO:0042832) | 3.56324043 |
37 | positive regulation of type 2 immune response (GO:0002830) | 3.52093752 |
38 | response to protozoan (GO:0001562) | 3.51815601 |
39 | positive regulation of B cell differentiation (GO:0045579) | 3.49885394 |
40 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.44638354 |
41 | regulation of gamma-delta T cell activation (GO:0046643) | 3.43420657 |
42 | NIK/NF-kappaB signaling (GO:0038061) | 3.43418112 |
43 | detection of external biotic stimulus (GO:0098581) | 3.42445014 |
44 | * response to interferon-gamma (GO:0034341) | 3.41399622 |
45 | myeloid dendritic cell activation (GO:0001773) | 3.38328238 |
46 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.36672093 |
47 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.36202916 |
48 | * T cell costimulation (GO:0031295) | 3.33099912 |
49 | regulation of interferon-alpha production (GO:0032647) | 3.30099266 |
50 | myeloid dendritic cell differentiation (GO:0043011) | 3.28413393 |
51 | * lymphocyte costimulation (GO:0031294) | 3.28003121 |
52 | negative thymic T cell selection (GO:0045060) | 3.26845257 |
53 | positive regulation of interferon-alpha production (GO:0032727) | 3.21727464 |
54 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.20319898 |
55 | positive regulation of macrophage cytokine production (GO:0060907) | 3.14005130 |
56 | production of molecular mediator of immune response (GO:0002440) | 3.12749851 |
57 | germinal center formation (GO:0002467) | 3.11336838 |
58 | regulation of mast cell degranulation (GO:0043304) | 3.08672814 |
59 | myeloid cell activation involved in immune response (GO:0002275) | 3.07211486 |
60 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 3.07131578 |
61 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.04666804 |
62 | response to host immune response (GO:0052572) | 3.04666804 |
63 | response to muramyl dipeptide (GO:0032495) | 3.04444296 |
64 | positive regulation of mast cell activation (GO:0033005) | 3.01599927 |
65 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.01395598 |
66 | detection of biotic stimulus (GO:0009595) | 3.01339300 |
67 | T cell migration (GO:0072678) | 2.99559355 |
68 | negative T cell selection (GO:0043383) | 2.99475844 |
69 | regulation of mast cell activation (GO:0033003) | 2.97769160 |
70 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.97673019 |
71 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.96873093 |
72 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.91466905 |
73 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.91064412 |
74 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.91035971 |
75 | respiratory burst (GO:0045730) | 2.90667790 |
76 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.89357345 |
77 | mature B cell differentiation involved in immune response (GO:0002313) | 2.89030438 |
78 | positive T cell selection (GO:0043368) | 2.87487484 |
79 | regulation of B cell differentiation (GO:0045577) | 2.87054634 |
80 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.85108215 |
81 | regulation of type 2 immune response (GO:0002828) | 2.83001951 |
82 | cellular extravasation (GO:0045123) | 2.81977486 |
83 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.77922389 |
84 | positive regulation of mast cell degranulation (GO:0043306) | 2.77922389 |
85 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.77715068 |
86 | regulation of T cell tolerance induction (GO:0002664) | 2.77285901 |
87 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.77217019 |
88 | response to host (GO:0075136) | 2.77217019 |
89 | response to host defenses (GO:0052200) | 2.77217019 |
90 | regulation of interleukin-12 production (GO:0032655) | 2.75756532 |
91 | thymic T cell selection (GO:0045061) | 2.74742569 |
92 | microglial cell activation (GO:0001774) | 2.74600131 |
93 | regulation of germinal center formation (GO:0002634) | 2.74535045 |
94 | regulation of hypersensitivity (GO:0002883) | 2.73950408 |
95 | adaptive immune response (GO:0002250) | 2.73586517 |
96 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.73129052 |
97 | positive regulation of neutrophil migration (GO:1902624) | 2.72498069 |
98 | positive regulation of neutrophil chemotaxis (GO:0090023) | 2.72498069 |
99 | granulocyte activation (GO:0036230) | 2.72341700 |
100 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.71438884 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 7.47843145 |
2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.52173337 |
3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.70503349 |
4 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.07133107 |
5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.53056219 |
6 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.25595540 |
7 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.13697659 |
8 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.10956576 |
9 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.99011452 |
10 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.96677444 |
11 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.81787243 |
12 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.65752421 |
13 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.65204139 |
14 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.59213047 |
15 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.58924701 |
16 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.57110979 |
17 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.44613606 |
18 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.41863187 |
19 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.31150221 |
20 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.25846708 |
21 | MYC_22102868_ChIP-Seq_BL_Human | 2.25217125 |
22 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.25090891 |
23 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.23404329 |
24 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.22450847 |
25 | MYB_26560356_Chip-Seq_TH2_Human | 2.18677417 |
26 | MAF_26560356_Chip-Seq_TH1_Human | 2.05268868 |
27 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.00094277 |
28 | SPI1_23127762_ChIP-Seq_K562_Human | 1.98552018 |
29 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.98167859 |
30 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.97238517 |
31 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.96455972 |
32 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.87819511 |
33 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.82143767 |
34 | MYB_26560356_Chip-Seq_TH1_Human | 1.79236566 |
35 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.76312260 |
36 | UTX_26944678_Chip-Seq_JUKART_Human | 1.69634450 |
37 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.66315913 |
38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.66128016 |
39 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64847864 |
40 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63766927 |
41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.63213732 |
42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59321755 |
43 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.58324475 |
44 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.58057380 |
45 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.45449537 |
46 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.45114028 |
47 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.44592852 |
48 | MAF_26560356_Chip-Seq_TH2_Human | 1.44509309 |
49 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.44073258 |
50 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.41234468 |
51 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.40428458 |
52 | GATA1_22025678_ChIP-Seq_K562_Human | 1.40173248 |
53 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.37437942 |
54 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.36031180 |
55 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.35803350 |
56 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.33113301 |
57 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.33005185 |
58 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.28118891 |
59 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.26292778 |
60 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.24476208 |
61 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.24473420 |
62 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.24390949 |
63 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.24028824 |
64 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.23199287 |
65 | GATA3_26560356_Chip-Seq_TH2_Human | 1.21130864 |
66 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.20562745 |
67 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.20130570 |
68 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.19155655 |
69 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.18774475 |
70 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.17396685 |
71 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14919458 |
72 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.14809608 |
73 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.14550683 |
74 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.14074428 |
75 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14061415 |
76 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.12568187 |
77 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.11237026 |
78 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.10304786 |
79 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.08788275 |
80 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07094207 |
81 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.06017586 |
82 | GATA1_19941826_ChIP-Seq_K562_Human | 1.02855380 |
83 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.02504200 |
84 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.02049002 |
85 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99355260 |
86 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.99196068 |
87 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.98093719 |
88 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91710935 |
89 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.90501644 |
90 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.87026292 |
91 | P300_27268052_Chip-Seq_Bcells_Human | 0.86708582 |
92 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86399992 |
93 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85948896 |
94 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.85637053 |
95 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.85428955 |
96 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.81721141 |
97 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.81195283 |
98 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.78787861 |
99 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.78106880 |
100 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.77755611 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001835_abnormal_antigen_presentation | 4.52195941 |
2 | MP0003303_peritoneal_inflammation | 3.92845805 |
3 | MP0005671_abnormal_response_to | 3.78663936 |
4 | MP0003436_decreased_susceptibility_to | 3.46774933 |
5 | MP0001790_abnormal_immune_system | 3.30242442 |
6 | MP0005387_immune_system_phenotype | 3.30242442 |
7 | MP0000685_abnormal_immune_system | 3.24164218 |
8 | MP0003724_increased_susceptibility_to | 3.22654725 |
9 | MP0002148_abnormal_hypersensitivity_rea | 3.21899396 |
10 | MP0005000_abnormal_immune_tolerance | 3.13302578 |
11 | MP0001800_abnormal_humoral_immune | 3.08836061 |
12 | MP0009785_altered_susceptibility_to | 2.96035330 |
13 | MP0005025_abnormal_response_to | 2.81893358 |
14 | MP0002452_abnormal_antigen_presenting | 2.73129660 |
15 | MP0002419_abnormal_innate_immunity | 2.72682090 |
16 | MP0006082_CNS_inflammation | 2.68140504 |
17 | MP0002723_abnormal_immune_serum | 2.64329225 |
18 | MP0002420_abnormal_adaptive_immunity | 2.42924395 |
19 | MP0005058_abnormal_lysosome_morphology | 2.42766850 |
20 | MP0001819_abnormal_immune_cell | 2.40856735 |
21 | MP0002138_abnormal_hepatobiliary_system | 2.20765532 |
22 | MP0010155_abnormal_intestine_physiology | 2.19003774 |
23 | MP0002139_abnormal_hepatobiliary_system | 2.01734780 |
24 | MP0001845_abnormal_inflammatory_respons | 1.91103490 |
25 | MP0003300_gastrointestinal_ulcer | 1.86634173 |
26 | MP0005464_abnormal_platelet_physiology | 1.85499628 |
27 | MP0000716_abnormal_immune_system | 1.83230356 |
28 | MP0003806_abnormal_nucleotide_metabolis | 1.82233035 |
29 | MP0001533_abnormal_skeleton_physiology | 1.80690067 |
30 | MP0009764_decreased_sensitivity_to | 1.77902729 |
31 | MP0002398_abnormal_bone_marrow | 1.76231176 |
32 | MP0003763_abnormal_thymus_physiology | 1.75985403 |
33 | MP0002405_respiratory_system_inflammati | 1.74594309 |
34 | MP0003075_altered_response_to | 1.73132287 |
35 | MP0009333_abnormal_splenocyte_physiolog | 1.71887828 |
36 | MP0004947_skin_inflammation | 1.68982067 |
37 | MP0003172_abnormal_lysosome_physiology | 1.66372645 |
38 | MP0009278_abnormal_bone_marrow | 1.63335569 |
39 | MP0003191_abnormal_cellular_cholesterol | 1.60973192 |
40 | MP0008469_abnormal_protein_level | 1.58140299 |
41 | MP0003183_abnormal_peptide_metabolism | 1.56783982 |
42 | MP0009840_abnormal_foam_cell | 1.54452526 |
43 | MP0001853_heart_inflammation | 1.53627664 |
44 | MP0000343_altered_response_to | 1.49572027 |
45 | MP0000689_abnormal_spleen_morphology | 1.49035818 |
46 | MP0005166_decreased_susceptibility_to | 1.48389324 |
47 | MP0005451_abnormal_body_composition | 1.48379604 |
48 | MP0002429_abnormal_blood_cell | 1.46658374 |
49 | MP0002166_altered_tumor_susceptibility | 1.45711206 |
50 | MP0005397_hematopoietic_system_phenotyp | 1.44985800 |
51 | MP0001545_abnormal_hematopoietic_system | 1.44985800 |
52 | MP0001873_stomach_inflammation | 1.39698297 |
53 | MP0005310_abnormal_salivary_gland | 1.37573524 |
54 | MP0004510_myositis | 1.35887706 |
55 | MP0000465_gastrointestinal_hemorrhage | 1.35123753 |
56 | MP0002722_abnormal_immune_system | 1.34308067 |
57 | MP0002998_abnormal_bone_remodeling | 1.25518266 |
58 | MP0000604_amyloidosis | 1.25284688 |
59 | MP0000858_altered_metastatic_potential | 1.23510184 |
60 | MP0003866_abnormal_defecation | 1.18960592 |
61 | MP0008004_abnormal_stomach_pH | 1.13418883 |
62 | MP0002006_tumorigenesis | 1.09749486 |
63 | MP0003448_altered_tumor_morphology | 1.02761649 |
64 | MP0001663_abnormal_digestive_system | 0.99687267 |
65 | MP0009763_increased_sensitivity_to | 0.94884872 |
66 | MP0005167_abnormal_blood-brain_barrier | 0.86575242 |
67 | MP0008260_abnormal_autophagy | 0.86225779 |
68 | MP0000703_abnormal_thymus_morphology | 0.82312350 |
69 | MP0000490_abnormal_crypts_of | 0.81230455 |
70 | MP0000249_abnormal_blood_vessel | 0.80819527 |
71 | MP0005165_increased_susceptibility_to | 0.79478093 |
72 | MP0002933_joint_inflammation | 0.78042348 |
73 | MP0001851_eye_inflammation | 0.76943134 |
74 | MP0003828_pulmonary_edema | 0.74948457 |
75 | MP0005390_skeleton_phenotype | 0.73559491 |
76 | MP0003690_abnormal_glial_cell | 0.72319764 |
77 | MP0009765_abnormal_xenobiotic_induced | 0.69937142 |
78 | MP0002396_abnormal_hematopoietic_system | 0.69207783 |
79 | MP0008874_decreased_physiological_sensi | 0.66591925 |
80 | MP0004883_abnormal_blood_vessel | 0.65189718 |
81 | MP0005164_abnormal_response_to | 0.64746457 |
82 | MP0005075_abnormal_melanosome_morpholog | 0.63866741 |
83 | MP0002254_reproductive_system_inflammat | 0.62385770 |
84 | MP0003045_fibrosis | 0.61736725 |
85 | MP0009643_abnormal_urine_homeostasis | 0.61289022 |
86 | MP0002136_abnormal_kidney_physiology | 0.59852007 |
87 | MP0004808_abnormal_hematopoietic_stem | 0.59538792 |
88 | MP0005360_urolithiasis | 0.59196604 |
89 | MP0003795_abnormal_bone_structure | 0.57935622 |
90 | MP0005319_abnormal_enzyme/_coenzyme | 0.57670253 |
91 | MP0005381_digestive/alimentary_phenotyp | 0.57443976 |
92 | MP0005535_abnormal_body_temperature | 0.56926060 |
93 | MP0000920_abnormal_myelination | 0.56138597 |
94 | MP0002019_abnormal_tumor_incidence | 0.55402474 |
95 | MP0003453_abnormal_keratinocyte_physiol | 0.55400595 |
96 | MP0000609_abnormal_liver_physiology | 0.54899357 |
97 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.54682814 |
98 | MP0002132_abnormal_respiratory_system | 0.53421529 |
99 | MP0005365_abnormal_bile_salt | 0.52665077 |
100 | MP0003656_abnormal_erythrocyte_physiolo | 0.52469598 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Eczematoid dermatitis (HP:0000976) | 4.91303009 |
2 | Recurrent bacterial skin infections (HP:0005406) | 4.77611113 |
3 | Abnormality of macrophages (HP:0004311) | 4.70232805 |
4 | Recurrent abscess formation (HP:0002722) | 4.54302933 |
5 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.51988307 |
6 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.51988307 |
7 | Abnormality of glycolipid metabolism (HP:0010969) | 4.51988307 |
8 | Mediastinal lymphadenopathy (HP:0100721) | 4.46212405 |
9 | Meningitis (HP:0001287) | 4.31114729 |
10 | Agammaglobulinemia (HP:0004432) | 4.18011254 |
11 | Systemic lupus erythematosus (HP:0002725) | 4.17513591 |
12 | Vasculitis (HP:0002633) | 3.90141621 |
13 | Obstructive lung disease (HP:0006536) | 3.85735299 |
14 | Chronic obstructive pulmonary disease (HP:0006510) | 3.85735299 |
15 | Gastrointestinal stroma tumor (HP:0100723) | 3.78576932 |
16 | Myositis (HP:0100614) | 3.73537216 |
17 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.66301328 |
18 | Recurrent fungal infections (HP:0002841) | 3.64005549 |
19 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.63647110 |
20 | Pulmonary infiltrates (HP:0002113) | 3.60174313 |
21 | Vacuolated lymphocytes (HP:0001922) | 3.53267999 |
22 | Orchitis (HP:0100796) | 3.46295032 |
23 | Urticaria (HP:0001025) | 3.40693496 |
24 | Increased cerebral lipofuscin (HP:0011813) | 3.37683327 |
25 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.37162040 |
26 | Retrobulbar optic neuritis (HP:0100654) | 3.36939020 |
27 | Optic neuritis (HP:0100653) | 3.36939020 |
28 | Recurrent skin infections (HP:0001581) | 3.36880122 |
29 | Recurrent viral infections (HP:0004429) | 3.33824748 |
30 | Recurrent cutaneous fungal infections (HP:0011370) | 3.32915932 |
31 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.32915932 |
32 | Cellulitis (HP:0100658) | 3.29284585 |
33 | Autoimmune thrombocytopenia (HP:0001973) | 3.11846601 |
34 | Abnormality of the prostate (HP:0008775) | 3.07619024 |
35 | Hemoptysis (HP:0002105) | 3.02972485 |
36 | Stomatitis (HP:0010280) | 3.02352074 |
37 | Colitis (HP:0002583) | 3.01975246 |
38 | Recurrent sinusitis (HP:0011108) | 2.99534019 |
39 | Recurrent bronchitis (HP:0002837) | 2.97149285 |
40 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.92069816 |
41 | Panhypogammaglobulinemia (HP:0003139) | 2.89694901 |
42 | Dysostosis multiplex (HP:0000943) | 2.89267710 |
43 | Encephalitis (HP:0002383) | 2.87872967 |
44 | Increased IgM level (HP:0003496) | 2.83503309 |
45 | Restrictive lung disease (HP:0002091) | 2.79234841 |
46 | Increased IgE level (HP:0003212) | 2.78699400 |
47 | Loss of speech (HP:0002371) | 2.75737401 |
48 | Spontaneous hematomas (HP:0007420) | 2.73437111 |
49 | Inflammation of the large intestine (HP:0002037) | 2.70726872 |
50 | Abnormality of the pleura (HP:0002103) | 2.69045608 |
51 | Lymphopenia (HP:0001888) | 2.66778090 |
52 | Chest pain (HP:0100749) | 2.66744987 |
53 | Chronic diarrhea (HP:0002028) | 2.65747417 |
54 | Petechiae (HP:0000967) | 2.64490248 |
55 | Recurrent pneumonia (HP:0006532) | 2.63640430 |
56 | Gastrointestinal inflammation (HP:0004386) | 2.63123499 |
57 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.55915004 |
58 | Gastrointestinal infarctions (HP:0005244) | 2.54716958 |
59 | Osteomyelitis (HP:0002754) | 2.53674190 |
60 | Abnormality of B cell number (HP:0010975) | 2.52186324 |
61 | Purpura (HP:0000979) | 2.50159572 |
62 | IgM deficiency (HP:0002850) | 2.46684527 |
63 | Hypertensive crisis (HP:0100735) | 2.45042317 |
64 | Recurrent lower respiratory tract infections (HP:0002783) | 2.44460331 |
65 | Gangrene (HP:0100758) | 2.44218142 |
66 | Abnormality of T cells (HP:0002843) | 2.43852983 |
67 | Keratoconjunctivitis sicca (HP:0001097) | 2.43286787 |
68 | Abnormality of T cell number (HP:0011839) | 2.43014803 |
69 | Pulmonary fibrosis (HP:0002206) | 2.42552824 |
70 | Skin rash (HP:0000988) | 2.41894476 |
71 | Hypergammaglobulinemia (HP:0010702) | 2.41436916 |
72 | IgA deficiency (HP:0002720) | 2.40841563 |
73 | Gingivitis (HP:0000230) | 2.39782958 |
74 | Emphysema (HP:0002097) | 2.38401825 |
75 | T lymphocytopenia (HP:0005403) | 2.37156190 |
76 | IgG deficiency (HP:0004315) | 2.36774904 |
77 | Pustule (HP:0200039) | 2.34677231 |
78 | Abnormality of T cell physiology (HP:0011840) | 2.30177616 |
79 | Autoimmune hemolytic anemia (HP:0001890) | 2.29217623 |
80 | Pulmonary embolism (HP:0002204) | 2.28332011 |
81 | Keratoconjunctivitis (HP:0001096) | 2.26887150 |
82 | Xerostomia (HP:0000217) | 2.26744161 |
83 | Chronic otitis media (HP:0000389) | 2.25045535 |
84 | Arthralgia (HP:0002829) | 2.21946551 |
85 | Hepatosplenomegaly (HP:0001433) | 2.20694647 |
86 | Glomerulonephritis (HP:0000099) | 2.19545939 |
87 | B lymphocytopenia (HP:0010976) | 2.19456997 |
88 | Sepsis (HP:0100806) | 2.19276434 |
89 | Disinhibition (HP:0000734) | 2.19213532 |
90 | Epistaxis (HP:0000421) | 2.19146510 |
91 | Polyneuropathy (HP:0001271) | 2.19062444 |
92 | Premature loss of primary teeth (HP:0006323) | 2.15605145 |
93 | Leukocytosis (HP:0001974) | 2.12957303 |
94 | Increased serum ferritin (HP:0003281) | 2.11682236 |
95 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.09443837 |
96 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.09443837 |
97 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.09443837 |
98 | Amyloidosis (HP:0011034) | 2.05638016 |
99 | Skin ulcer (HP:0200042) | 2.05313361 |
100 | Granulocytopenia (HP:0001913) | 2.04913924 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP4K1 | 4.47465268 |
2 | RIPK4 | 4.26964207 |
3 | BLK | 3.20322503 |
4 | ERN1 | 2.97703166 |
5 | TBK1 | 2.72844874 |
6 | KIT | 2.70816981 |
7 | TYK2 | 2.68464686 |
8 | MAP3K14 | 2.65877393 |
9 | IRAK4 | 2.31695803 |
10 | CSF1R | 2.30098706 |
11 | SYK | 2.29936676 |
12 | IKBKE | 2.19891982 |
13 | JAK3 | 2.14569997 |
14 | BMPR2 | 2.12847530 |
15 | NME2 | 2.00329233 |
16 | PRPF4B | 1.99071198 |
17 | MATK | 1.95503511 |
18 | IKBKB | 1.94688716 |
19 | TXK | 1.90528061 |
20 | CSK | 1.89926697 |
21 | FES | 1.83876416 |
22 | MAP3K13 | 1.72484955 |
23 | BTK | 1.70762143 |
24 | TAOK3 | 1.69881436 |
25 | LYN | 1.67187996 |
26 | TESK2 | 1.59185190 |
27 | IRAK3 | 1.52516614 |
28 | MAP2K3 | 1.51853074 |
29 | MAP3K11 | 1.49370734 |
30 | GRK7 | 1.47487657 |
31 | TLK1 | 1.42720219 |
32 | ZAP70 | 1.40367855 |
33 | FGR | 1.37525976 |
34 | JAK1 | 1.36572472 |
35 | KDR | 1.18707836 |
36 | LCK | 1.16548083 |
37 | HCK | 1.15836473 |
38 | TNK2 | 1.10820527 |
39 | ITK | 1.10296500 |
40 | TEC | 1.09483068 |
41 | GRK6 | 1.08960636 |
42 | TAOK2 | 1.07964326 |
43 | BCKDK | 1.07864285 |
44 | CDK19 | 1.07647806 |
45 | MAP3K3 | 1.07006980 |
46 | SIK3 | 1.05724747 |
47 | DDR2 | 1.04105587 |
48 | CDC42BPA | 1.02630497 |
49 | JAK2 | 0.96605150 |
50 | PIM2 | 0.93309852 |
51 | ACVR1B | 0.87271398 |
52 | PRKCQ | 0.84107646 |
53 | MAP3K1 | 0.81456959 |
54 | MARK3 | 0.77550050 |
55 | SIK2 | 0.77057263 |
56 | CHUK | 0.76030135 |
57 | PIM1 | 0.74435357 |
58 | TGFBR2 | 0.72690244 |
59 | MAPK7 | 0.72119013 |
60 | ADRBK2 | 0.68168305 |
61 | PDK1 | 0.65894264 |
62 | TAOK1 | 0.64013975 |
63 | ARAF | 0.62872566 |
64 | NEK9 | 0.61130667 |
65 | MAPK12 | 0.58927169 |
66 | MOS | 0.55024211 |
67 | DAPK3 | 0.54894584 |
68 | STK10 | 0.52989233 |
69 | SMG1 | 0.51913226 |
70 | HIPK2 | 0.48926028 |
71 | PDPK1 | 0.48286773 |
72 | ABL1 | 0.48265983 |
73 | IRAK1 | 0.46920238 |
74 | MAP2K6 | 0.46526301 |
75 | FGFR4 | 0.45030476 |
76 | CDK4 | 0.44860904 |
77 | MAP3K5 | 0.44384169 |
78 | MAPK11 | 0.43730989 |
79 | FYN | 0.42934026 |
80 | MAPK4 | 0.42638711 |
81 | PIK3CG | 0.42078366 |
82 | PRKCD | 0.41741021 |
83 | RIPK1 | 0.38907496 |
84 | ABL2 | 0.38592373 |
85 | MAPKAPK2 | 0.37010577 |
86 | RPS6KL1 | 0.36434526 |
87 | RPS6KC1 | 0.36434526 |
88 | CCNB1 | 0.34224806 |
89 | RPS6KA5 | 0.32961008 |
90 | DAPK2 | 0.30436802 |
91 | CDK6 | 0.30161501 |
92 | RPS6KA6 | 0.30079144 |
93 | FGFR3 | 0.27674843 |
94 | MAP2K2 | 0.26248734 |
95 | DAPK1 | 0.26052846 |
96 | IRAK2 | 0.25785350 |
97 | INSR | 0.25351695 |
98 | EPHB1 | 0.24369807 |
99 | SCYL2 | 0.24303190 |
100 | EGFR | 0.24228051 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Asthma_Homo sapiens_hsa05310 | 4.81758666 |
2 | * Allograft rejection_Homo sapiens_hsa05330 | 4.69998182 |
3 | * Autoimmune thyroid disease_Homo sapiens_hsa05320 | 4.29782511 |
4 | * Graft-versus-host disease_Homo sapiens_hsa05332 | 4.29262264 |
5 | * Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 4.13251324 |
6 | * Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.58595617 |
7 | * Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.46883040 |
8 | * Leishmaniasis_Homo sapiens_hsa05140 | 3.10164741 |
9 | * Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.83565750 |
10 | * Antigen processing and presentation_Homo sapiens_hsa04612 | 2.83349092 |
11 | * Viral myocarditis_Homo sapiens_hsa05416 | 2.58885597 |
12 | * Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.43048835 |
13 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.35783695 |
14 | * Tuberculosis_Homo sapiens_hsa05152 | 1.95176710 |
15 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.78725636 |
16 | Other glycan degradation_Homo sapiens_hsa00511 | 1.73505525 |
17 | * Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.72748568 |
18 | * Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.69453315 |
19 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.67669423 |
20 | * Toxoplasmosis_Homo sapiens_hsa05145 | 1.67243163 |
21 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.65048115 |
22 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.64667984 |
23 | * Influenza A_Homo sapiens_hsa05164 | 1.59110263 |
24 | * Herpes simplex infection_Homo sapiens_hsa05168 | 1.52240092 |
25 | * Phagosome_Homo sapiens_hsa04145 | 1.36385099 |
26 | Lysosome_Homo sapiens_hsa04142 | 1.30131487 |
27 | Pertussis_Homo sapiens_hsa05133 | 1.20131696 |
28 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.14479087 |
29 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.13400060 |
30 | * Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.11293743 |
31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.09257406 |
32 | Malaria_Homo sapiens_hsa05144 | 1.03225488 |
33 | Measles_Homo sapiens_hsa05162 | 1.02538130 |
34 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.00264225 |
35 | Legionellosis_Homo sapiens_hsa05134 | 0.99539331 |
36 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.95547190 |
37 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.88047540 |
38 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.84039487 |
39 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.82735376 |
40 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.82004012 |
41 | Salmonella infection_Homo sapiens_hsa05132 | 0.80157588 |
42 | * Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.79557082 |
43 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.75049946 |
44 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.73125643 |
45 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71858995 |
46 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.70993502 |
47 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.67963321 |
48 | Hepatitis C_Homo sapiens_hsa05160 | 0.64617140 |
49 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.64085143 |
50 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.59525295 |
51 | Shigellosis_Homo sapiens_hsa05131 | 0.59164659 |
52 | Apoptosis_Homo sapiens_hsa04210 | 0.55505282 |
53 | Hepatitis B_Homo sapiens_hsa05161 | 0.55244442 |
54 | * HTLV-I infection_Homo sapiens_hsa05166 | 0.52200132 |
55 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.50632411 |
56 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.45515836 |
57 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.45458042 |
58 | Platelet activation_Homo sapiens_hsa04611 | 0.41651918 |
59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41238404 |
60 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.39669195 |
61 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.34512059 |
62 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.33311083 |
63 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.31445794 |
64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.27889376 |
65 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.27100205 |
66 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.26745004 |
67 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.26555072 |
68 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.23953234 |
69 | Galactose metabolism_Homo sapiens_hsa00052 | 0.21252754 |
70 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.20501678 |
71 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.20280273 |
72 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.19357216 |
73 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.18367554 |
74 | Amoebiasis_Homo sapiens_hsa05146 | 0.18035373 |
75 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.18006868 |
76 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.16155955 |
77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.14541380 |
78 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.14142805 |
79 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.14093598 |
80 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.13840888 |
81 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.13619655 |
82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.12215088 |
83 | Endocytosis_Homo sapiens_hsa04144 | 0.11327898 |
84 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.10892849 |
85 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.10829510 |
86 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.10727972 |
87 | Prion diseases_Homo sapiens_hsa05020 | 0.10292689 |
88 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.10242897 |
89 | Alcoholism_Homo sapiens_hsa05034 | 0.07362874 |
90 | Bladder cancer_Homo sapiens_hsa05219 | 0.06858343 |
91 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.06387746 |
92 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.06348655 |
93 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.05520020 |
94 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.05449930 |
95 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.04911590 |
96 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.04486149 |
97 | Mineral absorption_Homo sapiens_hsa04978 | 0.04401733 |
98 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.00884729 |
99 | Insulin resistance_Homo sapiens_hsa04931 | 0.00051519 |
100 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0069805 |