HLA-DRB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.31105510
2antigen processing and presentation of endogenous antigen (GO:0019883)5.40229652
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.22807530
4positive regulation of gamma-delta T cell activation (GO:0046645)5.22190286
5neutrophil activation involved in immune response (GO:0002283)5.03375635
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00271278
7detection of other organism (GO:0098543)4.99146142
8detection of bacterium (GO:0016045)4.95064067
9B cell mediated immunity (GO:0019724)4.94675721
10regulation of antigen processing and presentation (GO:0002577)4.74099278
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.71540559
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62910303
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62910303
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.62910303
15modulation by symbiont of host immune response (GO:0052553)4.62910303
16positive regulation by symbiont of host defense response (GO:0052509)4.62910303
17modulation by symbiont of host defense response (GO:0052031)4.62910303
18positive regulation of antigen processing and presentation (GO:0002579)4.52969828
19negative regulation of cell killing (GO:0031342)4.47958477
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.47958477
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41955505
22response to peptidoglycan (GO:0032494)4.39690874
23macrophage activation involved in immune response (GO:0002281)4.32520295
24regulation of dendritic cell antigen processing and presentation (GO:0002604)4.28206583
25* interferon-gamma-mediated signaling pathway (GO:0060333)4.25916090
26negative regulation of interleukin-12 production (GO:0032695)4.22192058
27detection of external biotic stimulus (GO:0098581)4.01481240
28positive thymic T cell selection (GO:0045059)4.01136453
29regulation of B cell receptor signaling pathway (GO:0050855)3.97847574
30regulation of interferon-beta biosynthetic process (GO:0045357)3.85641668
31positive regulation of B cell differentiation (GO:0045579)3.84813163
32T-helper 1 type immune response (GO:0042088)3.75526284
33regulation of gamma-delta T cell activation (GO:0046643)3.68908271
34B cell receptor signaling pathway (GO:0050853)3.68789962
35positive regulation of mast cell activation (GO:0033005)3.66707778
36regulation of mast cell degranulation (GO:0043304)3.66023509
37positive regulation of mast cell degranulation (GO:0043306)3.63243653
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.63243653
39detection of biotic stimulus (GO:0009595)3.56595776
40microglial cell activation (GO:0001774)3.54368325
41myeloid cell activation involved in immune response (GO:0002275)3.45730566
42response to host immune response (GO:0052572)3.45038019
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.45038019
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43043433
45positive regulation of type 2 immune response (GO:0002830)3.40106770
46cellular extravasation (GO:0045123)3.37385750
47regulation of mast cell activation involved in immune response (GO:0033006)3.37383986
48cellular response to type I interferon (GO:0071357)3.33381894
49type I interferon signaling pathway (GO:0060337)3.33381894
50* cellular response to interferon-gamma (GO:0071346)3.32693208
51response to type I interferon (GO:0034340)3.30874790
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.29922463
53neutrophil activation (GO:0042119)3.26767804
54regulation of mast cell activation (GO:0033003)3.23642216
55macrophage activation (GO:0042116)3.23486542
56positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.23038589
57defense response to protozoan (GO:0042832)3.20617015
58regulation of gamma-delta T cell differentiation (GO:0045586)3.18406026
59regulation of B cell differentiation (GO:0045577)3.18153760
60detection of molecule of bacterial origin (GO:0032490)3.17436177
61granulocyte activation (GO:0036230)3.17346423
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15144512
63regulation of T cell tolerance induction (GO:0002664)3.12487382
64regulation of leukocyte degranulation (GO:0043300)3.11507288
65respiratory burst (GO:0045730)3.09953439
66response to host (GO:0075136)3.09864682
67response to host defenses (GO:0052200)3.09864682
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09864682
69positive regulation of interferon-alpha production (GO:0032727)3.08240976
70* response to interferon-gamma (GO:0034341)3.07949776
71regulation of tolerance induction (GO:0002643)3.06085724
72regulation of interferon-alpha production (GO:0032647)3.02943330
73lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02815837
74response to protozoan (GO:0001562)3.01293639
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00848937
76response to muramyl dipeptide (GO:0032495)2.98293794
77myeloid dendritic cell activation (GO:0001773)2.96191564
78positive T cell selection (GO:0043368)2.93303411
79NIK/NF-kappaB signaling (GO:0038061)2.92854029
80leukocyte aggregation (GO:0070486)2.92696763
81adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.91509126
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.91452395
83regulation of hypersensitivity (GO:0002883)2.89934293
84negative regulation of erythrocyte differentiation (GO:0045647)2.87232046
85antigen processing and presentation via MHC class Ib (GO:0002475)2.86180922
86positive regulation of leukocyte degranulation (GO:0043302)2.84673640
87negative regulation of innate immune response (GO:0045824)2.83445654
88* T cell costimulation (GO:0031295)2.81110241
89positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.80566523
90production of molecular mediator involved in inflammatory response (GO:0002532)2.79998695
91negative thymic T cell selection (GO:0045060)2.77289978
92* lymphocyte costimulation (GO:0031294)2.76687475
93negative regulation of lymphocyte mediated immunity (GO:0002707)2.76480296
94positive regulation of macrophage cytokine production (GO:0060907)2.74692910
95negative regulation of leukocyte mediated immunity (GO:0002704)2.73760633
96T cell selection (GO:0045058)2.73129019
97germinal center formation (GO:0002467)2.72167194
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70192524
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69900197
100T cell migration (GO:0072678)2.67388994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.32460743
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.42137244
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.62343280
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.57044087
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.36211317
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35478813
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.27979957
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15819658
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83749831
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82765072
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.74554652
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67601209
13SPI1_23547873_ChIP-Seq_NB4_Human2.65082985
14VDR_21846776_ChIP-Seq_THP-1_Human2.55103360
15VDR_24763502_ChIP-Seq_THP-1_Human2.54575245
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45073511
17SCL_19346495_ChIP-Seq_HPC-7_Human2.42829833
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41816872
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37325512
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35355505
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31550383
22SPI1_23127762_ChIP-Seq_K562_Human2.26939065
23MYB_26560356_Chip-Seq_TH2_Human2.17524069
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16297107
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16126163
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09536407
27MYC_22102868_ChIP-Seq_BL_Human2.01827299
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.00909695
29MAF_26560356_Chip-Seq_TH1_Human1.94987424
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94771999
31RUNX_20019798_ChIP-Seq_JUKART_Human1.94730769
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92132764
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86410237
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82681540
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80966621
36VDR_24787735_ChIP-Seq_THP-1_Human1.80209866
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77618452
38UTX_26944678_Chip-Seq_JUKART_Human1.75449719
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75381214
40MYB_26560356_Chip-Seq_TH1_Human1.71849558
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71534278
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.69640620
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67671429
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67297388
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65803138
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57070041
47GATA1_22025678_ChIP-Seq_K562_Human1.46674132
48GATA3_27048872_Chip-Seq_THYMUS_Human1.44506944
49CIITA_25753668_ChIP-Seq_RAJI_Human1.42249850
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42215867
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41182512
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39035052
53MAF_26560356_Chip-Seq_TH2_Human1.37472614
54BCL6_27268052_Chip-Seq_Bcells_Human1.35207756
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.34724546
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32052261
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30884264
58LXR_22292898_ChIP-Seq_THP-1_Human1.30419431
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30058279
60TCF7_22412390_ChIP-Seq_EML_Mouse1.29952753
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28961786
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27831681
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25930736
64GATA3_26560356_Chip-Seq_TH2_Human1.24317288
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21156297
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20124377
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19521524
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18940946
69BCOR_27268052_Chip-Seq_Bcells_Human1.18665792
70STAT1_20625510_ChIP-Seq_HELA_Human1.18271271
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16894160
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14643348
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13679739
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.12933902
75PU_27001747_Chip-Seq_BMDM_Mouse1.12560870
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11742447
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10985727
78KDM2B_26808549_Chip-Seq_DND41_Human1.10933659
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10337764
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09141769
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.09114544
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06896226
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04907581
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04132872
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.99368214
86GATA1_19941826_ChIP-Seq_K562_Human0.98974087
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98330509
88SPI1_20517297_ChIP-Seq_HL60_Human0.97629151
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95354499
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94002501
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92656317
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91394068
93P300_27268052_Chip-Seq_Bcells_Human0.89518808
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86129657
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.83373798
96TFEB_21752829_ChIP-Seq_HELA_Human0.82633672
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80974420
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80493586
99NCOR1_26117541_ChIP-Seq_K562_Human0.80416673
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78854757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.57109029
2MP0003724_increased_susceptibility_to3.74090662
3MP0003436_decreased_susceptibility_to3.53340527
4MP0003303_peritoneal_inflammation3.46186089
5MP0005671_abnormal_response_to3.27364648
6MP0002148_abnormal_hypersensitivity_rea3.09738821
7MP0001790_abnormal_immune_system3.09267751
8MP0005387_immune_system_phenotype3.09267751
9MP0002419_abnormal_innate_immunity2.99503165
10MP0001800_abnormal_humoral_immune2.99066794
11MP0005000_abnormal_immune_tolerance2.98307044
12MP0000685_abnormal_immune_system2.92223389
13MP0009785_altered_susceptibility_to2.87271622
14MP0005025_abnormal_response_to2.83855543
15MP0006082_CNS_inflammation2.82658763
16MP0002452_abnormal_antigen_presenting2.74000532
17MP0005058_abnormal_lysosome_morphology2.66913635
18MP0002723_abnormal_immune_serum2.63875803
19MP0003172_abnormal_lysosome_physiology2.52748724
20MP0002420_abnormal_adaptive_immunity2.45251331
21MP0001819_abnormal_immune_cell2.43685825
22MP0003191_abnormal_cellular_cholesterol2.23664849
23MP0005464_abnormal_platelet_physiology2.07083657
24MP0003300_gastrointestinal_ulcer2.02288880
25MP0010155_abnormal_intestine_physiology1.93576028
26MP0001533_abnormal_skeleton_physiology1.90545047
27MP0001845_abnormal_inflammatory_respons1.88909155
28MP0009840_abnormal_foam_cell1.85514687
29MP0002405_respiratory_system_inflammati1.83776562
30MP0000716_abnormal_immune_system1.82136459
31MP0009278_abnormal_bone_marrow1.80042159
32MP0003806_abnormal_nucleotide_metabolis1.77923734
33MP0009764_decreased_sensitivity_to1.77315070
34MP0003075_altered_response_to1.75003652
35MP0002398_abnormal_bone_marrow1.71953132
36MP0003763_abnormal_thymus_physiology1.64703406
37MP0002138_abnormal_hepatobiliary_system1.63396576
38MP0001545_abnormal_hematopoietic_system1.63091651
39MP0005397_hematopoietic_system_phenotyp1.63091651
40MP0008469_abnormal_protein_level1.62090620
41MP0003828_pulmonary_edema1.54022779
42MP0000689_abnormal_spleen_morphology1.53959626
43MP0009333_abnormal_splenocyte_physiolog1.53327011
44MP0001853_heart_inflammation1.52438930
45MP0000465_gastrointestinal_hemorrhage1.50859102
46MP0004947_skin_inflammation1.50719804
47MP0003183_abnormal_peptide_metabolism1.48558131
48MP0000604_amyloidosis1.46845378
49MP0002429_abnormal_blood_cell1.45397776
50MP0000343_altered_response_to1.41423042
51MP0005166_decreased_susceptibility_to1.38592036
52MP0005310_abnormal_salivary_gland1.37958079
53MP0002722_abnormal_immune_system1.36468695
54MP0003866_abnormal_defecation1.27775014
55MP0002998_abnormal_bone_remodeling1.25679307
56MP0000858_altered_metastatic_potential1.24527040
57MP0002166_altered_tumor_susceptibility1.23256552
58MP0002139_abnormal_hepatobiliary_system1.14433325
59MP0005451_abnormal_body_composition1.09685247
60MP0003690_abnormal_glial_cell1.07270030
61MP0001873_stomach_inflammation1.06195248
62MP0002396_abnormal_hematopoietic_system1.00530893
63MP0003448_altered_tumor_morphology1.00394119
64MP0008260_abnormal_autophagy0.98957406
65MP0002132_abnormal_respiratory_system0.98133066
66MP0001663_abnormal_digestive_system0.95246482
67MP0001851_eye_inflammation0.95027533
68MP0009763_increased_sensitivity_to0.92814846
69MP0004510_myositis0.88410099
70MP0000703_abnormal_thymus_morphology0.88112952
71MP0005075_abnormal_melanosome_morpholog0.86883110
72MP0008004_abnormal_stomach_pH0.86447862
73MP0002006_tumorigenesis0.84869249
74MP0005167_abnormal_blood-brain_barrier0.84354216
75MP0000015_abnormal_ear_pigmentation0.84163191
76MP0004883_abnormal_blood_vessel0.82452766
77MP0002277_abnormal_respiratory_mucosa0.82401399
78MP0004808_abnormal_hematopoietic_stem0.81025621
79MP0005164_abnormal_response_to0.79496122
80MP0005390_skeleton_phenotype0.79013544
81MP0000249_abnormal_blood_vessel0.77258978
82MP0002933_joint_inflammation0.72089650
83MP0000920_abnormal_myelination0.71268401
84MP0000490_abnormal_crypts_of0.70994320
85MP0005165_increased_susceptibility_to0.70900105
86MP0009765_abnormal_xenobiotic_induced0.70443342
87MP0003656_abnormal_erythrocyte_physiolo0.68965191
88MP0003795_abnormal_bone_structure0.61843757
89MP0005365_abnormal_bile_salt0.61720267
90MP0005319_abnormal_enzyme/_coenzyme0.57136686
91MP0005584_abnormal_enzyme/coenzyme_acti0.55910831
92MP0008874_decreased_physiological_sensi0.54465704
93MP0001986_abnormal_taste_sensitivity0.52761772
94MP0005381_digestive/alimentary_phenotyp0.52537479
95MP0000609_abnormal_liver_physiology0.52375478
96MP0003329_amyloid_beta_deposits0.50964235
97MP0002136_abnormal_kidney_physiology0.50697992
98MP0004381_abnormal_hair_follicle0.49263692
99MP0009643_abnormal_urine_homeostasis0.48511520
100MP0002019_abnormal_tumor_incidence0.46437456

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.26798907
2Recurrent abscess formation (HP:0002722)5.16574729
3Eczematoid dermatitis (HP:0000976)5.02851304
4Abnormality of glycolipid metabolism (HP:0010969)4.98840536
5Abnormality of liposaccharide metabolism (HP:0010968)4.98840536
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.98840536
7Abnormality of macrophages (HP:0004311)4.77625428
8Systemic lupus erythematosus (HP:0002725)4.43887192
9Mediastinal lymphadenopathy (HP:0100721)4.25961808
10Meningitis (HP:0001287)4.09858853
11Agammaglobulinemia (HP:0004432)4.08128778
12Myositis (HP:0100614)4.07802948
13Increased cerebral lipofuscin (HP:0011813)4.05114991
14Recurrent gram-negative bacterial infections (HP:0005420)3.95950223
15Chronic obstructive pulmonary disease (HP:0006510)3.94933746
16Obstructive lung disease (HP:0006536)3.94933746
17Elevated erythrocyte sedimentation rate (HP:0003565)3.94383965
18Recurrent fungal infections (HP:0002841)3.73197722
19Orchitis (HP:0100796)3.69100319
20Recurrent skin infections (HP:0001581)3.66669229
21Stomatitis (HP:0010280)3.49283314
22Recurrent cutaneous fungal infections (HP:0011370)3.49173623
23Chronic mucocutaneous candidiasis (HP:0002728)3.49173623
24Retrobulbar optic neuritis (HP:0100654)3.48090417
25Optic neuritis (HP:0100653)3.48090417
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.46588782
27Panhypogammaglobulinemia (HP:0003139)3.31369063
28Vasculitis (HP:0002633)3.30742961
29Pulmonary infiltrates (HP:0002113)3.29284758
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.29218510
31Cellulitis (HP:0100658)3.24944281
32Recurrent viral infections (HP:0004429)3.24831846
33Dysostosis multiplex (HP:0000943)3.18596758
34Vacuolated lymphocytes (HP:0001922)3.16899878
35Urticaria (HP:0001025)3.10244468
36Abnormality of the prostate (HP:0008775)3.06866683
37Loss of speech (HP:0002371)3.05667346
38Encephalitis (HP:0002383)2.99161096
39Increased IgE level (HP:0003212)2.91516615
40Hemoptysis (HP:0002105)2.90822152
41Spontaneous hematomas (HP:0007420)2.84586598
42Autoimmune thrombocytopenia (HP:0001973)2.84107101
43Colitis (HP:0002583)2.81036600
44Chest pain (HP:0100749)2.79094470
45Gingivitis (HP:0000230)2.73343308
46Disinhibition (HP:0000734)2.66067567
47Purpura (HP:0000979)2.65296504
48Gastrointestinal infarctions (HP:0005244)2.63696084
49Osteomyelitis (HP:0002754)2.63055238
50Pustule (HP:0200039)2.62226272
51Inflammation of the large intestine (HP:0002037)2.61792813
52Gastrointestinal stroma tumor (HP:0100723)2.60396783
53Glomerulonephritis (HP:0000099)2.57464856
54Keratoconjunctivitis sicca (HP:0001097)2.50940710
55Gastrointestinal inflammation (HP:0004386)2.50834072
56Abnormality of polysaccharide metabolism (HP:0011012)2.48371016
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48371016
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48371016
59Restrictive lung disease (HP:0002091)2.47190463
60Petechiae (HP:0000967)2.46373634
61Amyloidosis (HP:0011034)2.44982991
62Abnormality of the pleura (HP:0002103)2.42130021
63Recurrent pneumonia (HP:0006532)2.35223249
64Epistaxis (HP:0000421)2.35205782
65Increased serum ferritin (HP:0003281)2.34458501
66Keratoconjunctivitis (HP:0001096)2.34040780
67Mucopolysacchariduria (HP:0008155)2.33337794
68Urinary glycosaminoglycan excretion (HP:0003541)2.33337794
69Pulmonary embolism (HP:0002204)2.31291031
70Chronic otitis media (HP:0000389)2.31003397
71Increased IgM level (HP:0003496)2.29925448
72T lymphocytopenia (HP:0005403)2.29870078
73Hypergammaglobulinemia (HP:0010702)2.28993011
74Recurrent sinusitis (HP:0011108)2.28588415
75Recurrent bronchitis (HP:0002837)2.26640031
76Prolonged bleeding time (HP:0003010)2.26207407
77Hepatosplenomegaly (HP:0001433)2.25972363
78Premature loss of primary teeth (HP:0006323)2.25082469
79Abnormality of T cell number (HP:0011839)2.25024332
80Skin rash (HP:0000988)2.24802894
81Sepsis (HP:0100806)2.24633442
82Leukocytosis (HP:0001974)2.24221936
83Abnormality of T cells (HP:0002843)2.20604196
84Prostate neoplasm (HP:0100787)2.20575669
85Granulocytopenia (HP:0001913)2.19428981
86Recurrent lower respiratory tract infections (HP:0002783)2.18732937
87Arterial thrombosis (HP:0004420)2.16914129
88Gangrene (HP:0100758)2.15030452
89Hypertensive crisis (HP:0100735)2.14149675
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12250948
91Abnormality of B cell number (HP:0010975)2.11449038
92Lymphopenia (HP:0001888)2.11224915
93Polyneuropathy (HP:0001271)2.11027966
94Abnormality of iron homeostasis (HP:0011031)2.08903947
95Mutism (HP:0002300)2.08579813
96IgM deficiency (HP:0002850)2.08381664
97Complement deficiency (HP:0004431)2.07994943
98Pulmonary fibrosis (HP:0002206)2.07324925
99Abnormality of T cell physiology (HP:0011840)2.06859119
100Thrombocytosis (HP:0001894)2.03734216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.26483769
2BLK4.03947628
3MAP4K14.02336875
4ERN13.67569679
5TYK22.95525640
6KIT2.65848327
7FES2.44432148
8MAP3K142.40153908
9TBK12.34981228
10CSF1R2.29745345
11SYK2.24161630
12IRAK42.19410648
13JAK32.01145403
14IKBKE2.00075613
15BTK1.99771221
16CSK1.99174744
17NME21.98795557
18TXK1.93133069
19TNK21.87916272
20ZAP701.83959916
21MAP2K31.82039635
22TAOK31.79481411
23MAP3K131.77781976
24LYN1.73536164
25IKBKB1.69794443
26MAP3K111.69054150
27BMPR21.64262343
28MAP3K31.54650249
29SIK31.53023132
30PRPF4B1.46997477
31HCK1.46524990
32TEC1.44921795
33TESK21.42986643
34FGR1.39562323
35GRK61.38331207
36MATK1.35836214
37ITK1.34492840
38JAK11.33463921
39LCK1.27447715
40IRAK31.17104593
41JAK21.09066013
42TGFBR21.08692061
43GRK71.04764694
44BCKDK0.95411217
45MAP3K10.94812418
46KDR0.93234247
47CDK190.85477535
48MARK30.82190136
49CDC42BPA0.79442864
50TAOK20.74486984
51TAOK10.71405150
52PDK10.70389000
53PRKCQ0.69472088
54MAPK70.61569565
55PDPK10.61343748
56FYN0.59281445
57ABL10.58990559
58MAPK120.58561370
59CHUK0.58042803
60ABL20.57336901
61STK100.55012250
62LRRK20.54192783
63SIK20.51737123
64PIM20.49742368
65PIK3CG0.49051490
66IRAK10.47313692
67RIPK10.47043915
68HIPK20.45548619
69EPHB10.43879774
70PIM10.43403210
71RPS6KL10.42506446
72RPS6KC10.42506446
73MAPKAPK20.41695674
74MAP3K50.40302205
75MAP2K60.39914670
76CDK60.39884285
77MAPK40.39596790
78MAP2K20.38994680
79PRKD20.38228688
80PRKCD0.37349215
81ADRBK20.36960993
82MAPK110.36616587
83RPS6KA60.36480027
84IRAK20.36340388
85TLK10.36072368
86CDK40.34252377
87SMG10.34073869
88MARK20.32694300
89CAMKK20.30631831
90FGFR30.28487719
91PRKD10.25542660
92DAPK20.25361397
93DDR20.25267800
94IGF1R0.24749867
95MAPK30.24524525
96PDK20.22947664
97TESK10.22239809
98EGFR0.22235095
99MOS0.22090563
100ACVR1B0.21691436

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053104.32305490
2* Allograft rejection_Homo sapiens_hsa053304.24836991
3* Graft-versus-host disease_Homo sapiens_hsa053323.99833432
4* Autoimmune thyroid disease_Homo sapiens_hsa053203.93721466
5* Staphylococcus aureus infection_Homo sapiens_hsa051503.93133418
6* Intestinal immune network for IgA production_Homo sapiens_hsa046723.48761097
7* Type I diabetes mellitus_Homo sapiens_hsa049403.27952997
8* Leishmaniasis_Homo sapiens_hsa051403.20234608
9* Antigen processing and presentation_Homo sapiens_hsa046122.81946589
10* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.64778319
11Other glycan degradation_Homo sapiens_hsa005112.46582970
12* Viral myocarditis_Homo sapiens_hsa054162.36527492
13* Rheumatoid arthritis_Homo sapiens_hsa053232.30167974
14Primary immunodeficiency_Homo sapiens_hsa053402.25107685
15Osteoclast differentiation_Homo sapiens_hsa043802.19539440
16* Tuberculosis_Homo sapiens_hsa051522.13591283
17B cell receptor signaling pathway_Homo sapiens_hsa046621.80761705
18Lysosome_Homo sapiens_hsa041421.72941729
19* Hematopoietic cell lineage_Homo sapiens_hsa046401.68198188
20* Toxoplasmosis_Homo sapiens_hsa051451.66410654
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64373059
22* Phagosome_Homo sapiens_hsa041451.62992265
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.59999253
24* Influenza A_Homo sapiens_hsa051641.51095010
25* Herpes simplex infection_Homo sapiens_hsa051681.47164697
26Pertussis_Homo sapiens_hsa051331.37057946
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35906618
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.31221231
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20285473
30Malaria_Homo sapiens_hsa051441.18532268
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17903617
32Legionellosis_Homo sapiens_hsa051341.12874395
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10421325
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04806192
35* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04258453
36Measles_Homo sapiens_hsa051621.01430490
37Chemokine signaling pathway_Homo sapiens_hsa040620.99442328
38* Systemic lupus erythematosus_Homo sapiens_hsa053220.90761285
39TNF signaling pathway_Homo sapiens_hsa046680.89762398
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88065243
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84789704
42African trypanosomiasis_Homo sapiens_hsa051430.82985928
43Salmonella infection_Homo sapiens_hsa051320.82668075
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81768990
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.80395226
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78228007
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77511114
48T cell receptor signaling pathway_Homo sapiens_hsa046600.75885029
49Acute myeloid leukemia_Homo sapiens_hsa052210.72938668
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70248368
51* Epstein-Barr virus infection_Homo sapiens_hsa051690.69835393
52Platelet activation_Homo sapiens_hsa046110.66054000
53Shigellosis_Homo sapiens_hsa051310.65874632
54Hepatitis C_Homo sapiens_hsa051600.61270685
55Hepatitis B_Homo sapiens_hsa051610.60364517
56Apoptosis_Homo sapiens_hsa042100.56828076
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.56250799
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56208452
59Complement and coagulation cascades_Homo sapiens_hsa046100.48478797
60* HTLV-I infection_Homo sapiens_hsa051660.47691087
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47079365
62Collecting duct acid secretion_Homo sapiens_hsa049660.45245597
63Arachidonic acid metabolism_Homo sapiens_hsa005900.38429443
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35558936
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33613804
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.33312463
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31633633
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29696906
69Endocytosis_Homo sapiens_hsa041440.26608844
70Amoebiasis_Homo sapiens_hsa051460.25488203
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.25383261
72Non-small cell lung cancer_Homo sapiens_hsa052230.23583665
73Viral carcinogenesis_Homo sapiens_hsa052030.23223161
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22109737
75VEGF signaling pathway_Homo sapiens_hsa043700.21616640
76Prolactin signaling pathway_Homo sapiens_hsa049170.21005134
77Pancreatic cancer_Homo sapiens_hsa052120.20743259
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.20090185
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.17968373
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17641549
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16933156
82Ether lipid metabolism_Homo sapiens_hsa005650.16817059
83Prion diseases_Homo sapiens_hsa050200.16502865
84Sphingolipid metabolism_Homo sapiens_hsa006000.16374736
85Renin-angiotensin system_Homo sapiens_hsa046140.14976356
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13779950
87Notch signaling pathway_Homo sapiens_hsa043300.13087661
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12780413
89Chronic myeloid leukemia_Homo sapiens_hsa052200.12706611
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.11106627
91Galactose metabolism_Homo sapiens_hsa000520.08247132
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.07459373
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06633633
94Bladder cancer_Homo sapiens_hsa052190.06316381
95HIF-1 signaling pathway_Homo sapiens_hsa040660.06294345
96Insulin resistance_Homo sapiens_hsa049310.03084568
97GnRH signaling pathway_Homo sapiens_hsa049120.02690620
98Fructose and mannose metabolism_Homo sapiens_hsa000510.02486403
99PPAR signaling pathway_Homo sapiens_hsa033200.01692552
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.00212256

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