HLA-DRB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.06158627
2B cell mediated immunity (GO:0019724)5.54171372
3antigen processing and presentation of endogenous antigen (GO:0019883)5.21988162
4regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.02079224
5* interferon-gamma-mediated signaling pathway (GO:0060333)4.78570722
6regulation of antigen processing and presentation (GO:0002577)4.71912419
7positive regulation of gamma-delta T cell activation (GO:0046645)4.71412539
8positive thymic T cell selection (GO:0045059)4.60423244
9positive regulation of antigen processing and presentation (GO:0002579)4.59174269
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56077183
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43196741
12detection of bacterium (GO:0016045)4.41789935
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36600236
14detection of other organism (GO:0098543)4.29178293
15neutrophil activation involved in immune response (GO:0002283)4.24582744
16regulation of dendritic cell antigen processing and presentation (GO:0002604)4.21468864
17T-helper 1 type immune response (GO:0042088)4.06569421
18type I interferon signaling pathway (GO:0060337)4.03363871
19cellular response to type I interferon (GO:0071357)4.03363871
20response to type I interferon (GO:0034340)4.00948359
21negative regulation of cell killing (GO:0031342)3.94536362
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94536362
23negative regulation of interleukin-12 production (GO:0032695)3.91126034
24response to peptidoglycan (GO:0032494)3.85432033
25* cellular response to interferon-gamma (GO:0071346)3.83896544
26macrophage activation involved in immune response (GO:0002281)3.79402365
27* response to interferon-gamma (GO:0034341)3.53435467
28detection of external biotic stimulus (GO:0098581)3.53222458
29positive regulation of type 2 immune response (GO:0002830)3.50112620
30response to interferon-beta (GO:0035456)3.47343071
31regulation of gamma-delta T cell activation (GO:0046643)3.45763171
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.44629634
33modulation by symbiont of host immune response (GO:0052553)3.44629634
34positive regulation by symbiont of host defense response (GO:0052509)3.44629634
35modulation by symbiont of host defense response (GO:0052031)3.44629634
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44629634
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44629634
38positive T cell selection (GO:0043368)3.42887481
39eosinophil chemotaxis (GO:0048245)3.42384562
40production of molecular mediator of immune response (GO:0002440)3.40927039
41regulation of B cell receptor signaling pathway (GO:0050855)3.39440818
42negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.36383689
43* T cell costimulation (GO:0031295)3.35651456
44* lymphocyte costimulation (GO:0031294)3.30409173
45positive regulation of B cell differentiation (GO:0045579)3.28645059
46chaperone mediated protein folding requiring cofactor (GO:0051085)3.25011746
47eosinophil migration (GO:0072677)3.22445065
48defense response to protozoan (GO:0042832)3.19553668
49myeloid cell activation involved in immune response (GO:0002275)3.18133275
50regulation of T-helper 1 cell differentiation (GO:0045625)3.17218280
51adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.15451732
52granulocyte activation (GO:0036230)3.15419288
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14225510
54B cell receptor signaling pathway (GO:0050853)3.14063997
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12586931
56germinal center formation (GO:0002467)3.09635408
57myeloid dendritic cell activation (GO:0001773)3.09027022
58detection of biotic stimulus (GO:0009595)3.08451673
59regulation of interferon-alpha production (GO:0032647)3.06905551
60regulation of interferon-beta biosynthetic process (GO:0045357)3.06528686
61neutrophil activation (GO:0042119)3.04391775
62regulation of T cell tolerance induction (GO:0002664)3.03115769
63response to protozoan (GO:0001562)2.97605562
64negative regulation of viral genome replication (GO:0045071)2.94266333
65myeloid dendritic cell differentiation (GO:0043011)2.93399636
66positive regulation of interferon-alpha production (GO:0032727)2.93224024
67T cell migration (GO:0072678)2.92847223
68regulation of gamma-delta T cell differentiation (GO:0045586)2.92291557
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89213282
70regulation of mononuclear cell migration (GO:0071675)2.86188461
71regulation of tolerance induction (GO:0002643)2.82916918
72regulation of inflammatory response to antigenic stimulus (GO:0002861)2.81849379
73regulation of macrophage chemotaxis (GO:0010758)2.80539713
74T cell selection (GO:0045058)2.78625838
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77019817
76response to host immune response (GO:0052572)2.77019817
77lymphocyte mediated immunity (GO:0002449)2.76677390
78regulation of mast cell activation (GO:0033003)2.76553238
79positive regulation of lymphocyte migration (GO:2000403)2.76540993
80lymphocyte chemotaxis (GO:0048247)2.76206694
81thymic T cell selection (GO:0045061)2.75741755
82adaptive immune response (GO:0002250)2.74836911
83negative regulation of cytokine production involved in immune response (GO:0002719)2.74503587
84microglial cell activation (GO:0001774)2.74247586
85regulation of mast cell degranulation (GO:0043304)2.74036661
86Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71582283
87regulation of type 2 immune response (GO:0002828)2.71069282
88negative thymic T cell selection (GO:0045060)2.70481079
89regulation of lymphocyte migration (GO:2000401)2.69942194
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69642371
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69620850
92detection of molecule of bacterial origin (GO:0032490)2.68426220
93antigen processing and presentation via MHC class Ib (GO:0002475)2.66213494
94regulation of alpha-beta T cell proliferation (GO:0046640)2.64401121
95NIK/NF-kappaB signaling (GO:0038061)2.63927483
96regulation of B cell differentiation (GO:0045577)2.62794056
97macrophage activation (GO:0042116)2.62444621
98cellular response to exogenous dsRNA (GO:0071360)2.61683503
99peptide catabolic process (GO:0043171)2.60502954
100cytidine catabolic process (GO:0006216)2.60089585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.62691515
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.00074046
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.86158873
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.70742152
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41121857
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.29618936
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15681302
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03264691
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90642033
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81903574
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64316187
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61421201
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53372987
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52079394
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50253341
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39039892
17SPI1_23547873_ChIP-Seq_NB4_Human2.25491452
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22714006
19VDR_24763502_ChIP-Seq_THP-1_Human2.18607640
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15827917
21MYB_26560356_Chip-Seq_TH2_Human2.13444896
22RUNX_20019798_ChIP-Seq_JUKART_Human2.08008442
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91759197
24VDR_21846776_ChIP-Seq_THP-1_Human1.91388000
25SPI1_23127762_ChIP-Seq_K562_Human1.90452666
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88348210
27SCL_19346495_ChIP-Seq_HPC-7_Human1.81121826
28VDR_24787735_ChIP-Seq_THP-1_Human1.76532282
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.74905479
30MAF_26560356_Chip-Seq_TH1_Human1.74853851
31MYB_26560356_Chip-Seq_TH1_Human1.71352092
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70730940
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68100953
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66766600
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62180455
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60733743
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56438657
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56022493
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53648118
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.53555928
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48240382
42UTX_26944678_Chip-Seq_JUKART_Human1.46247866
43GATA3_27048872_Chip-Seq_THYMUS_Human1.46175017
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45048494
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43234306
46GATA3_26560356_Chip-Seq_TH2_Human1.33608665
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31666974
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30128197
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29989241
50MYC_22102868_ChIP-Seq_BL_Human1.27624658
51GATA1_22025678_ChIP-Seq_K562_Human1.27345342
52STAT1_20625510_ChIP-Seq_HELA_Human1.22758059
53BCL6_27268052_Chip-Seq_Bcells_Human1.22339251
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20910697
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19598978
56MAF_26560356_Chip-Seq_TH2_Human1.18906852
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.16734499
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15175382
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14951005
60* CIITA_25753668_ChIP-Seq_RAJI_Human1.13468590
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10821566
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.09500877
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09038551
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08533572
65BCOR_27268052_Chip-Seq_Bcells_Human1.07569913
66LXR_22292898_ChIP-Seq_THP-1_Human1.06739631
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06593640
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06189819
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05227971
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05094215
71PU_27001747_Chip-Seq_BMDM_Mouse1.02440461
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01817068
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01786170
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.00301155
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98716023
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96808416
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96223546
78TCF7_22412390_ChIP-Seq_EML_Mouse0.96164076
79PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93782092
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92988088
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91850682
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.91585307
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90797602
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90615041
85GATA1_19941826_ChIP-Seq_K562_Human0.89912304
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.89718879
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89261583
88RXR_22158963_ChIP-Seq_LIVER_Mouse0.88986522
89EGR1_19032775_ChIP-ChIP_M12_Human0.86840780
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86505362
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83168341
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81797078
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80861740
94P300_27268052_Chip-Seq_Bcells_Human0.79430384
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76536200
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73803711
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73009498
98KDM2B_26808549_Chip-Seq_DND41_Human0.72957132
99SPI1_20517297_ChIP-Seq_HL60_Human0.72693066
100LXR_22158963_ChIP-Seq_LIVER_Mouse0.71959670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.43567457
2MP0005671_abnormal_response_to3.59986083
3MP0003724_increased_susceptibility_to3.54067007
4MP0003436_decreased_susceptibility_to3.43230918
5MP0003303_peritoneal_inflammation3.34626447
6MP0002148_abnormal_hypersensitivity_rea3.28474008
7MP0009785_altered_susceptibility_to3.24710761
8MP0001790_abnormal_immune_system3.03388482
9MP0005387_immune_system_phenotype3.03388482
10MP0005000_abnormal_immune_tolerance2.99393260
11MP0006082_CNS_inflammation2.92772733
12MP0001800_abnormal_humoral_immune2.89776253
13MP0005025_abnormal_response_to2.80442211
14MP0002419_abnormal_innate_immunity2.71327607
15MP0000685_abnormal_immune_system2.65706904
16MP0002452_abnormal_antigen_presenting2.56988901
17MP0005058_abnormal_lysosome_morphology2.55672651
18MP0002723_abnormal_immune_serum2.54635227
19MP0010155_abnormal_intestine_physiology2.33950414
20MP0002420_abnormal_adaptive_immunity2.29684855
21MP0001819_abnormal_immune_cell2.28091438
22MP0009840_abnormal_foam_cell2.20573323
23MP0003183_abnormal_peptide_metabolism2.00772590
24MP0002138_abnormal_hepatobiliary_system1.97863234
25MP0003300_gastrointestinal_ulcer1.97350725
26MP0001533_abnormal_skeleton_physiology1.96527157
27MP0002139_abnormal_hepatobiliary_system1.94266843
28MP0001845_abnormal_inflammatory_respons1.94259965
29MP0009764_decreased_sensitivity_to1.83672206
30MP0003172_abnormal_lysosome_physiology1.82903723
31MP0005464_abnormal_platelet_physiology1.79508513
32MP0000716_abnormal_immune_system1.72999266
33MP0003075_altered_response_to1.72902443
34MP0009333_abnormal_splenocyte_physiolog1.70950724
35MP0003191_abnormal_cellular_cholesterol1.69647030
36MP0008469_abnormal_protein_level1.66880729
37MP0004947_skin_inflammation1.57681365
38MP0002398_abnormal_bone_marrow1.57516032
39MP0002405_respiratory_system_inflammati1.57033583
40MP0003763_abnormal_thymus_physiology1.55228665
41MP0002166_altered_tumor_susceptibility1.50895655
42MP0003806_abnormal_nucleotide_metabolis1.49061558
43MP0000343_altered_response_to1.48185264
44MP0003866_abnormal_defecation1.45930284
45MP0001853_heart_inflammation1.43108796
46MP0005166_decreased_susceptibility_to1.40686626
47MP0002429_abnormal_blood_cell1.35416495
48MP0000689_abnormal_spleen_morphology1.33093335
49MP0000604_amyloidosis1.32644123
50MP0002998_abnormal_bone_remodeling1.32033607
51MP0005310_abnormal_salivary_gland1.28786932
52MP0005360_urolithiasis1.22020143
53MP0002722_abnormal_immune_system1.20532305
54MP0001873_stomach_inflammation1.20523151
55MP0008004_abnormal_stomach_pH1.19138299
56MP0005167_abnormal_blood-brain_barrier1.15483548
57MP0009278_abnormal_bone_marrow1.13453407
58MP0003448_altered_tumor_morphology1.11364853
59MP0000858_altered_metastatic_potential1.08556049
60MP0005365_abnormal_bile_salt1.07947258
61MP0001663_abnormal_digestive_system1.05099688
62MP0000465_gastrointestinal_hemorrhage1.05078466
63MP0005451_abnormal_body_composition1.04670757
64MP0002006_tumorigenesis1.03906234
65MP0005397_hematopoietic_system_phenotyp0.98167710
66MP0001545_abnormal_hematopoietic_system0.98167710
67MP0009763_increased_sensitivity_to0.96522112
68MP0005165_increased_susceptibility_to0.96276120
69MP0003828_pulmonary_edema0.95752205
70MP0004510_myositis0.94519722
71MP0003690_abnormal_glial_cell0.87602908
72MP0000249_abnormal_blood_vessel0.87396227
73MP0002933_joint_inflammation0.84583557
74MP0005390_skeleton_phenotype0.81852817
75MP0000490_abnormal_crypts_of0.80411584
76MP0006054_spinal_hemorrhage0.79709715
77MP0009643_abnormal_urine_homeostasis0.79333890
78MP0004883_abnormal_blood_vessel0.78380378
79MP0002277_abnormal_respiratory_mucosa0.78234369
80MP0005164_abnormal_response_to0.77058326
81MP0000703_abnormal_thymus_morphology0.75376698
82MP0000920_abnormal_myelination0.71532921
83MP0005319_abnormal_enzyme/_coenzyme0.70920512
84MP0002136_abnormal_kidney_physiology0.70909166
85MP0009765_abnormal_xenobiotic_induced0.70452998
86MP0008260_abnormal_autophagy0.69705587
87MP0003045_fibrosis0.67522119
88MP0003656_abnormal_erythrocyte_physiolo0.67322573
89MP0005085_abnormal_gallbladder_physiolo0.65872309
90MP0003795_abnormal_bone_structure0.64921880
91MP0001666_abnormal_nutrient_absorption0.64354381
92MP0005584_abnormal_enzyme/coenzyme_acti0.64285879
93MP0005381_digestive/alimentary_phenotyp0.63144058
94MP0001501_abnormal_sleep_pattern0.62652313
95MP0000609_abnormal_liver_physiology0.61958863
96MP0001851_eye_inflammation0.61422122
97MP0004782_abnormal_surfactant_physiolog0.58774253
98MP0004019_abnormal_vitamin_homeostasis0.56766432
99MP0005535_abnormal_body_temperature0.54480426
100MP0002396_abnormal_hematopoietic_system0.54383269

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.36794002
2Recurrent abscess formation (HP:0002722)4.46170675
3Recurrent bacterial skin infections (HP:0005406)4.44722486
4Abnormality of glycolipid metabolism (HP:0010969)4.37146001
5Abnormality of liposaccharide metabolism (HP:0010968)4.37146001
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.37146001
7Abnormality of macrophages (HP:0004311)4.28435273
8Eczematoid dermatitis (HP:0000976)4.17560900
9Mediastinal lymphadenopathy (HP:0100721)3.97057275
10Meningitis (HP:0001287)3.94041689
11Elevated erythrocyte sedimentation rate (HP:0003565)3.93688900
12Myositis (HP:0100614)3.92264579
13Pulmonary infiltrates (HP:0002113)3.71521442
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.69973232
15Orchitis (HP:0100796)3.68219574
16Vasculitis (HP:0002633)3.57291017
17Chronic obstructive pulmonary disease (HP:0006510)3.51645798
18Obstructive lung disease (HP:0006536)3.51645798
19Optic neuritis (HP:0100653)3.49051173
20Retrobulbar optic neuritis (HP:0100654)3.49051173
21Chronic mucocutaneous candidiasis (HP:0002728)3.44711817
22Recurrent cutaneous fungal infections (HP:0011370)3.44711817
23Recurrent fungal infections (HP:0002841)3.42957441
24Abnormality of the prostate (HP:0008775)3.38228781
25Increased cerebral lipofuscin (HP:0011813)3.36801354
26Recurrent skin infections (HP:0001581)3.35364684
27Glomerulonephritis (HP:0000099)3.33973753
28Agammaglobulinemia (HP:0004432)3.29448774
29Vacuolated lymphocytes (HP:0001922)3.23891069
30Recurrent gram-negative bacterial infections (HP:0005420)3.20775464
31Encephalitis (HP:0002383)3.19157337
32Stomatitis (HP:0010280)3.15800012
33Hemoptysis (HP:0002105)3.15087951
34Dysostosis multiplex (HP:0000943)3.12854122
35Panhypogammaglobulinemia (HP:0003139)3.11274758
36Urticaria (HP:0001025)3.10643887
37Recurrent viral infections (HP:0004429)3.05700718
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.02513785
39Chronic diarrhea (HP:0002028)2.91678843
40Autoimmune thrombocytopenia (HP:0001973)2.86013769
41Loss of speech (HP:0002371)2.81801807
42Chest pain (HP:0100749)2.81330517
43Pustule (HP:0200039)2.79796220
44Colitis (HP:0002583)2.78697942
45Abnormality of the pleura (HP:0002103)2.75060836
46Complement deficiency (HP:0004431)2.74468530
47Gastrointestinal stroma tumor (HP:0100723)2.69720969
48Disinhibition (HP:0000734)2.66920659
49Increased IgM level (HP:0003496)2.66050565
50Abnormality of T cell number (HP:0011839)2.64432998
51Inflammation of the large intestine (HP:0002037)2.60739353
52Petechiae (HP:0000967)2.60673930
53Recurrent bronchitis (HP:0002837)2.60173186
54Gastrointestinal infarctions (HP:0005244)2.59624896
55Keratoconjunctivitis sicca (HP:0001097)2.54295411
56T lymphocytopenia (HP:0005403)2.53721650
57Abnormality of T cells (HP:0002843)2.52173128
58Gangrene (HP:0100758)2.49879297
59Pulmonary fibrosis (HP:0002206)2.49088481
60Pulmonary embolism (HP:0002204)2.45616136
61Restrictive lung disease (HP:0002091)2.43306024
62Gastrointestinal inflammation (HP:0004386)2.42419311
63Abnormality of complement system (HP:0005339)2.42380492
64Abnormality of T cell physiology (HP:0011840)2.42088357
65Spontaneous hematomas (HP:0007420)2.41998693
66Gingivitis (HP:0000230)2.40126596
67Malnutrition (HP:0004395)2.38627275
68Increased serum ferritin (HP:0003281)2.37608538
69Abnormality of polysaccharide metabolism (HP:0011012)2.35762400
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35762400
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35762400
72Autoimmune hemolytic anemia (HP:0001890)2.33838503
73Cellulitis (HP:0100658)2.32708047
74Keratoconjunctivitis (HP:0001096)2.31926983
75Hypergammaglobulinemia (HP:0010702)2.30253070
76Purpura (HP:0000979)2.30144657
77Amyloidosis (HP:0011034)2.29709052
78Mutism (HP:0002300)2.29254604
79Increased IgE level (HP:0003212)2.26808057
80Skin rash (HP:0000988)2.26172543
81Chronic otitis media (HP:0000389)2.26042694
82Mucopolysacchariduria (HP:0008155)2.20541988
83Urinary glycosaminoglycan excretion (HP:0003541)2.20541988
84Xerostomia (HP:0000217)2.20348637
85Polyneuropathy (HP:0001271)2.18251794
86Abnormality of iron homeostasis (HP:0011031)2.15735038
87Prostate neoplasm (HP:0100787)2.13226064
88Nephritis (HP:0000123)2.12408018
89Recurrent sinusitis (HP:0011108)2.12207837
90Osteomyelitis (HP:0002754)2.10308270
91Arthralgia (HP:0002829)2.07994469
92Arterial thrombosis (HP:0004420)2.07916475
93Hepatosplenomegaly (HP:0001433)2.06712918
94Lymphopenia (HP:0001888)2.06480211
95Abnormality of the peritoneum (HP:0002585)2.06438807
96Memory impairment (HP:0002354)2.05961032
97Epistaxis (HP:0000421)2.05813172
98IgM deficiency (HP:0002850)2.05749483
99Abnormality of B cell number (HP:0010975)2.04668625
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.04207605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.26053716
2MAP4K14.03761406
3BLK3.72911945
4ERN12.99496703
5TYK22.91280267
6TXK2.88965934
7KIT2.73731384
8TBK12.61072934
9MAP3K142.52048442
10FES2.50094890
11IRAK42.45301425
12BMPR22.41773032
13SYK2.32823716
14CSF1R2.26874299
15IKBKE2.08679970
16JAK32.08627755
17CSK2.06383006
18ZAP701.78347826
19IKBKB1.77489838
20LYN1.74559250
21MATK1.73249653
22GRK71.72278022
23TESK21.70322004
24BTK1.67436708
25JAK11.61035576
26TAOK31.57464489
27ITK1.43692563
28IRAK31.38984821
29MAP2K31.35273184
30LCK1.31335109
31TEC1.29867428
32HCK1.27595104
33TGFBR21.26832843
34ACVR1B1.25382558
35FGR1.24331985
36PRPF4B1.17460510
37MAP3K111.16985814
38GRK61.11792786
39JAK21.09574388
40TNK21.09090236
41MAP3K31.07152391
42NME21.04550409
43CDC42BPA0.97934277
44KDR0.94810419
45MAP3K130.91144259
46TGFBR10.91129124
47SIK30.89964045
48ADRBK20.87662836
49BMPR1B0.85550698
50IRAK10.83535110
51RIPK10.82395428
52PRKCQ0.81747390
53DDR20.76842574
54TLK10.76644386
55TAOK20.76532185
56TAOK10.74223114
57CHUK0.71392703
58PDK10.67505024
59CAMKK20.66958466
60MAPK110.65195532
61MAP3K10.62042841
62MAP2K60.60515753
63MAPK70.59752348
64STK100.59587122
65BCKDK0.59119516
66SMG10.57500332
67MARK30.56358489
68ABL10.54351269
69FGFR40.53739750
70FYN0.52897647
71MAPKAPK30.51274386
72FGFR30.51009082
73PRKG20.50594159
74HIPK20.50365103
75PDPK10.49909589
76MAPK120.48536251
77PIK3CG0.48455411
78MAPKAPK20.46993859
79PRKCD0.45090073
80LRRK20.43259165
81PIM10.41761140
82IGF1R0.39493412
83CDK190.39134722
84DAPK20.38273601
85ABL20.37897874
86IRAK20.34562676
87EPHA30.33866795
88MAP3K50.33784942
89CDK90.33358714
90EGFR0.33180273
91MAP2K20.32262040
92MST40.31733891
93EPHB10.31337514
94GRK10.29979944
95SIK20.29688018
96INSR0.28388089
97CDK60.28061161
98CLK10.27486307
99RPS6KC10.26459817
100RPS6KL10.26459817

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053104.74907580
2* Allograft rejection_Homo sapiens_hsa053304.61601149
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.31943017
4* Graft-versus-host disease_Homo sapiens_hsa053324.27951679
5* Staphylococcus aureus infection_Homo sapiens_hsa051503.88180264
6* Intestinal immune network for IgA production_Homo sapiens_hsa046723.76431158
7* Type I diabetes mellitus_Homo sapiens_hsa049403.51863267
8* Leishmaniasis_Homo sapiens_hsa051402.98936358
9* Antigen processing and presentation_Homo sapiens_hsa046122.94158086
10* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.70699314
11* Viral myocarditis_Homo sapiens_hsa054162.45028711
12* Rheumatoid arthritis_Homo sapiens_hsa053232.43449630
13Primary immunodeficiency_Homo sapiens_hsa053401.91705450
14* Tuberculosis_Homo sapiens_hsa051521.88413457
15Other glycan degradation_Homo sapiens_hsa005111.88072014
16Osteoclast differentiation_Homo sapiens_hsa043801.68746490
17* Hematopoietic cell lineage_Homo sapiens_hsa046401.68587751
18* Toxoplasmosis_Homo sapiens_hsa051451.58181301
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54968052
20* Influenza A_Homo sapiens_hsa051641.53720836
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.48538718
22* Herpes simplex infection_Homo sapiens_hsa051681.43791539
23* Phagosome_Homo sapiens_hsa041451.34865560
24Lysosome_Homo sapiens_hsa041421.33068178
25B cell receptor signaling pathway_Homo sapiens_hsa046621.31765046
26Pertussis_Homo sapiens_hsa051331.26825242
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19353537
28* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17235828
29* Systemic lupus erythematosus_Homo sapiens_hsa053221.13671695
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10581927
31Malaria_Homo sapiens_hsa051441.10528837
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05333306
33Measles_Homo sapiens_hsa051621.02025779
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99252705
35Legionellosis_Homo sapiens_hsa051340.91732863
36TNF signaling pathway_Homo sapiens_hsa046680.91344382
37Chemokine signaling pathway_Homo sapiens_hsa040620.91102698
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90624354
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89246125
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87352840
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.86900089
42African trypanosomiasis_Homo sapiens_hsa051430.86303609
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84660132
44Salmonella infection_Homo sapiens_hsa051320.79527568
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.74182826
46T cell receptor signaling pathway_Homo sapiens_hsa046600.72201051
47Hepatitis C_Homo sapiens_hsa051600.68510147
48Renin-angiotensin system_Homo sapiens_hsa046140.66855711
49* Epstein-Barr virus infection_Homo sapiens_hsa051690.59821259
50Shigellosis_Homo sapiens_hsa051310.55091558
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53489455
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52887378
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51997091
54Complement and coagulation cascades_Homo sapiens_hsa046100.51791850
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51536278
56Apoptosis_Homo sapiens_hsa042100.47078870
57Sulfur metabolism_Homo sapiens_hsa009200.46510743
58Arachidonic acid metabolism_Homo sapiens_hsa005900.46280157
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.44650787
60Fat digestion and absorption_Homo sapiens_hsa049750.44181256
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44041200
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.43953416
63Mineral absorption_Homo sapiens_hsa049780.42494275
64Vitamin digestion and absorption_Homo sapiens_hsa049770.41745752
65Platelet activation_Homo sapiens_hsa046110.38093641
66* HTLV-I infection_Homo sapiens_hsa051660.38036047
67Hepatitis B_Homo sapiens_hsa051610.35861319
68Sphingolipid metabolism_Homo sapiens_hsa006000.34726271
69Linoleic acid metabolism_Homo sapiens_hsa005910.32814322
70Prion diseases_Homo sapiens_hsa050200.32219398
71Acute myeloid leukemia_Homo sapiens_hsa052210.32001246
72PPAR signaling pathway_Homo sapiens_hsa033200.31774136
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30182373
74Collecting duct acid secretion_Homo sapiens_hsa049660.30025630
75Caffeine metabolism_Homo sapiens_hsa002320.28338354
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.25229301
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25009589
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24392893
79Ether lipid metabolism_Homo sapiens_hsa005650.22369257
80Tryptophan metabolism_Homo sapiens_hsa003800.20787011
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20258400
82Histidine metabolism_Homo sapiens_hsa003400.19167703
83Galactose metabolism_Homo sapiens_hsa000520.18917634
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18574594
85Amoebiasis_Homo sapiens_hsa051460.17898954
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.17293207
87Viral carcinogenesis_Homo sapiens_hsa052030.16314747
88Prolactin signaling pathway_Homo sapiens_hsa049170.15920197
89Fructose and mannose metabolism_Homo sapiens_hsa000510.15062948
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.13725116
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12854602
92Endocytosis_Homo sapiens_hsa041440.12736117
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10525747
94Starch and sucrose metabolism_Homo sapiens_hsa005000.09896225
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.08519379
96VEGF signaling pathway_Homo sapiens_hsa043700.06017744
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.05633115
98Insulin resistance_Homo sapiens_hsa049310.04898837
99Chemical carcinogenesis_Homo sapiens_hsa052040.04878086
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.03912699

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