HLA-DRB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.19885898
2B cell mediated immunity (GO:0019724)5.73489826
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.63834874
4interferon-gamma-mediated signaling pathway (GO:0060333)5.29858221
5regulation of antigen processing and presentation (GO:0002577)5.28199259
6positive regulation of antigen processing and presentation (GO:0002579)5.07721112
7regulation of dendritic cell antigen processing and presentation (GO:0002604)4.63585638
8antigen processing and presentation of endogenous antigen (GO:0019883)4.25078352
9cellular response to interferon-gamma (GO:0071346)4.24635429
10negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.22989384
11positive thymic T cell selection (GO:0045059)4.21037492
12neutrophil activation involved in immune response (GO:0002283)4.09390189
13production of molecular mediator of immune response (GO:0002440)4.07755408
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06145250
15T-helper 1 type immune response (GO:0042088)4.05832788
16detection of bacterium (GO:0016045)3.91179487
17response to interferon-gamma (GO:0034341)3.87796844
18T cell costimulation (GO:0031295)3.86492909
19lymphocyte costimulation (GO:0031294)3.80804979
20chaperone mediated protein folding requiring cofactor (GO:0051085)3.74272551
21detection of other organism (GO:0098543)3.70939379
22regulation of B cell receptor signaling pathway (GO:0050855)3.61506430
23positive regulation of gamma-delta T cell activation (GO:0046645)3.59387060
24regulation of inflammatory response to antigenic stimulus (GO:0002861)3.55373150
25positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.54358853
26DNA deamination (GO:0045006)3.49995428
27B cell receptor signaling pathway (GO:0050853)3.43353978
28regulation of hypersensitivity (GO:0002883)3.40150178
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38316717
30response to interferon-beta (GO:0035456)3.33976368
31regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.30722509
32mast cell activation (GO:0045576)3.30111218
33regulation of T-helper 1 cell differentiation (GO:0045625)3.24985459
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24029784
35type I interferon signaling pathway (GO:0060337)3.20920790
36cellular response to type I interferon (GO:0071357)3.20920790
37response to type I interferon (GO:0034340)3.16753296
38defense response to protozoan (GO:0042832)3.14715121
39positive regulation of type 2 immune response (GO:0002830)3.10553160
40regulation of germinal center formation (GO:0002634)3.03746630
41response to protozoan (GO:0001562)3.01319850
42myeloid cell activation involved in immune response (GO:0002275)2.99626511
43regulation of mast cell activation (GO:0033003)2.99518677
44antigen receptor-mediated signaling pathway (GO:0050851)2.98933099
45leukocyte degranulation (GO:0043299)2.98594724
46positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92712478
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90194177
48antigen processing and presentation via MHC class Ib (GO:0002475)2.88876480
49positive regulation of interferon-gamma production (GO:0032729)2.88822090
50regulation of interleukin-1 beta secretion (GO:0050706)2.86967065
51positive regulation of mast cell degranulation (GO:0043306)2.86649412
52positive regulation of mast cell activation involved in immune response (GO:0033008)2.86649412
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85806668
54adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.85540903
55positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.83585022
56mast cell activation involved in immune response (GO:0002279)2.83495900
57mast cell degranulation (GO:0043303)2.83495900
58myeloid dendritic cell activation (GO:0001773)2.82837041
59negative regulation of interleukin-12 production (GO:0032695)2.81824595
60positive regulation of mast cell activation (GO:0033005)2.81338802
61positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80995293
62response to peptidoglycan (GO:0032494)2.79584804
63positive T cell selection (GO:0043368)2.79243167
64positive regulation of T-helper 1 type immune response (GO:0002827)2.78124740
65negative thymic T cell selection (GO:0045060)2.77746037
66mature B cell differentiation involved in immune response (GO:0002313)2.77555472
67positive regulation of B cell differentiation (GO:0045579)2.77279189
68positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74162536
69neutrophil activation (GO:0042119)2.73705008
70positive regulation of interleukin-1 beta secretion (GO:0050718)2.73560817
71peptide catabolic process (GO:0043171)2.73275513
72regulation of T cell mediated cytotoxicity (GO:0001914)2.72693182
73regulation of B cell apoptotic process (GO:0002902)2.71675520
74detection of external biotic stimulus (GO:0098581)2.71611870
75regulation of alpha-beta T cell proliferation (GO:0046640)2.71051308
76regulation of gamma-delta T cell activation (GO:0046643)2.70037376
77purine deoxyribonucleotide catabolic process (GO:0009155)2.69447319
78regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.68238025
79T cell receptor signaling pathway (GO:0050852)2.68171312
80regulation of mast cell degranulation (GO:0043304)2.67987932
81regulation of T cell tolerance induction (GO:0002664)2.66808208
82positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.66052069
83cellular response to interferon-beta (GO:0035458)2.64471210
84T cell migration (GO:0072678)2.63962296
85positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.63455689
86natural killer cell activation involved in immune response (GO:0002323)2.61875679
87positive regulation of T cell activation (GO:0050870)2.61134081
88cytidine metabolic process (GO:0046087)2.60737196
89cytidine catabolic process (GO:0006216)2.60737196
90cytidine deamination (GO:0009972)2.60737196
91positive regulation of interleukin-12 production (GO:0032735)2.60393420
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59194306
93positive regulation of interleukin-1 secretion (GO:0050716)2.59093548
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58977152
95negative regulation of cell killing (GO:0031342)2.58977152
96regulation of interleukin-10 production (GO:0032653)2.57070068
97positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.56679286
98positive regulation of T cell proliferation (GO:0042102)2.55135603
99granulocyte activation (GO:0036230)2.54628338
100adaptive immune response (GO:0002250)2.54010190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.83148305
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.60689450
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.52955130
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.17673153
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87385698
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00886321
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00350383
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.74805785
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58663317
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54757974
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50824710
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45911542
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41001613
14SPI1_23547873_ChIP-Seq_NB4_Human2.37922982
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36524286
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33792737
17CIITA_25753668_ChIP-Seq_RAJI_Human2.26123883
18MYB_26560356_Chip-Seq_TH2_Human2.16556625
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14000775
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09847680
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99823970
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93013670
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89058138
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86130000
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83937828
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80708780
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77745165
28GATA3_26560356_Chip-Seq_TH2_Human1.76739320
29RUNX_20019798_ChIP-Seq_JUKART_Human1.70357853
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69764071
31SCL_19346495_ChIP-Seq_HPC-7_Human1.67344522
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64972612
33MYB_26560356_Chip-Seq_TH1_Human1.64791810
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60811493
35GATA3_27048872_Chip-Seq_THYMUS_Human1.58606003
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53896857
37VDR_23849224_ChIP-Seq_CD4+_Human1.53500304
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51127266
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49788947
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49116191
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46894684
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45387269
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.44121588
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41922382
45STAT1_20625510_ChIP-Seq_HELA_Human1.38846202
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37980506
47VDR_24763502_ChIP-Seq_THP-1_Human1.37456205
48SPI1_23127762_ChIP-Seq_K562_Human1.35731129
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.34645353
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34538683
51BCL6_27268052_Chip-Seq_Bcells_Human1.31544586
52GATA1_22025678_ChIP-Seq_K562_Human1.29682241
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26492861
54MAF_26560356_Chip-Seq_TH1_Human1.24943861
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24680096
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23033270
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21320286
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.18897149
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.18373573
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15849765
61VDR_24787735_ChIP-Seq_THP-1_Human1.14740317
62P300_27268052_Chip-Seq_Bcells_Human1.14614148
63FOXP3_21729870_ChIP-Seq_TREG_Human1.14120547
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13832622
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13308395
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.12660480
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12203470
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10485518
69UTX_26944678_Chip-Seq_JUKART_Human1.09938419
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09591963
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04272564
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04086846
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02028686
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01879182
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00885387
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98952267
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98101705
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97597423
79IRF1_19129219_ChIP-ChIP_H3396_Human0.96690760
80BCOR_27268052_Chip-Seq_Bcells_Human0.96527556
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94614417
82TAF2_19829295_ChIP-Seq_ESCs_Human0.94548900
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.93701730
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92686094
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90499893
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90419109
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90353802
88ETS1_20019798_ChIP-Seq_JURKAT_Human0.89557359
89VDR_21846776_ChIP-Seq_THP-1_Human0.87295503
90TFEB_21752829_ChIP-Seq_HELA_Human0.87084796
91SPI1_20517297_ChIP-Seq_HL60_Human0.86234483
92ZNF274_21170338_ChIP-Seq_K562_Hela0.86066562
93MYC_22102868_ChIP-Seq_BL_Human0.85746956
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85742825
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84270640
96NANOG_20526341_ChIP-Seq_ESCs_Human0.83791411
97SMRT_27268052_Chip-Seq_Bcells_Human0.83696334
98E2F1_20622854_ChIP-Seq_HELA_Human0.83438743
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83005900
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81830128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.89672719
2MP0005671_abnormal_response_to3.72332266
3MP0003724_increased_susceptibility_to3.52421730
4MP0000685_abnormal_immune_system3.18956831
5MP0002148_abnormal_hypersensitivity_rea3.08789099
6MP0001800_abnormal_humoral_immune3.05782426
7MP0001790_abnormal_immune_system3.01917580
8MP0005387_immune_system_phenotype3.01917580
9MP0005000_abnormal_immune_tolerance2.99058712
10MP0003436_decreased_susceptibility_to2.94735139
11MP0002139_abnormal_hepatobiliary_system2.84716261
12MP0009785_altered_susceptibility_to2.79670904
13MP0009840_abnormal_foam_cell2.67854029
14MP0002452_abnormal_antigen_presenting2.62310886
15MP0002138_abnormal_hepatobiliary_system2.53423333
16MP0002723_abnormal_immune_serum2.52338469
17MP0003806_abnormal_nucleotide_metabolis2.50212979
18MP0005025_abnormal_response_to2.38040676
19MP0003303_peritoneal_inflammation2.36827051
20MP0002419_abnormal_innate_immunity2.36257214
21MP0002420_abnormal_adaptive_immunity2.29331274
22MP0001819_abnormal_immune_cell2.27759651
23MP0006082_CNS_inflammation2.18167278
24MP0005058_abnormal_lysosome_morphology2.15467848
25MP0002166_altered_tumor_susceptibility2.03758229
26MP0010155_abnormal_intestine_physiology2.03582371
27MP0009764_decreased_sensitivity_to1.90464946
28MP0005464_abnormal_platelet_physiology1.82701895
29MP0000716_abnormal_immune_system1.72207353
30MP0001845_abnormal_inflammatory_respons1.69904383
31MP0002398_abnormal_bone_marrow1.67762713
32MP0005360_urolithiasis1.62590357
33MP0001533_abnormal_skeleton_physiology1.60031293
34MP0002006_tumorigenesis1.54693636
35MP0003763_abnormal_thymus_physiology1.52705692
36MP0003183_abnormal_peptide_metabolism1.52658433
37MP0009333_abnormal_splenocyte_physiolog1.49398794
38MP0000689_abnormal_spleen_morphology1.44536720
39MP0005075_abnormal_melanosome_morpholog1.43358555
40MP0002429_abnormal_blood_cell1.43327988
41MP0000465_gastrointestinal_hemorrhage1.41145856
42MP0001853_heart_inflammation1.40509622
43MP0002405_respiratory_system_inflammati1.37644266
44MP0008469_abnormal_protein_level1.37586327
45MP0005167_abnormal_blood-brain_barrier1.36570197
46MP0005310_abnormal_salivary_gland1.32269406
47MP0003866_abnormal_defecation1.31489438
48MP0005397_hematopoietic_system_phenotyp1.29275819
49MP0001545_abnormal_hematopoietic_system1.29275819
50MP0003075_altered_response_to1.27277424
51MP0003191_abnormal_cellular_cholesterol1.24036872
52MP0004947_skin_inflammation1.22574781
53MP0002722_abnormal_immune_system1.21676952
54MP0009278_abnormal_bone_marrow1.20138567
55MP0008875_abnormal_xenobiotic_pharmacok1.16824920
56MP0006036_abnormal_mitochondrial_physio1.15855548
57MP0001873_stomach_inflammation1.12791271
58MP0002876_abnormal_thyroid_physiology1.10212323
59MP0003172_abnormal_lysosome_physiology1.10079839
60MP0008004_abnormal_stomach_pH1.01776932
61MP0003646_muscle_fatigue1.00320767
62MP0005166_decreased_susceptibility_to0.99792775
63MP0005365_abnormal_bile_salt0.96502981
64MP0002998_abnormal_bone_remodeling0.93115609
65MP0005085_abnormal_gallbladder_physiolo0.90378392
66MP0000858_altered_metastatic_potential0.89482364
67MP0003300_gastrointestinal_ulcer0.86620578
68MP0009643_abnormal_urine_homeostasis0.84980363
69MP0008872_abnormal_physiological_respon0.84192010
70MP0000371_diluted_coat_color0.83629918
71MP0000343_altered_response_to0.81819733
72MP0001666_abnormal_nutrient_absorption0.79257955
73MP0000490_abnormal_crypts_of0.78160240
74MP0001764_abnormal_homeostasis0.76660655
75MP0001663_abnormal_digestive_system0.76638354
76MP0005174_abnormal_tail_pigmentation0.75583067
77MP0000015_abnormal_ear_pigmentation0.74838718
78MP0009763_increased_sensitivity_to0.74565023
79MP0005165_increased_susceptibility_to0.73288148
80MP0002136_abnormal_kidney_physiology0.72237597
81MP0000249_abnormal_blood_vessel0.72053942
82MP0000703_abnormal_thymus_morphology0.70330217
83MP0004782_abnormal_surfactant_physiolog0.69891312
84MP0004147_increased_porphyrin_level0.68598372
85MP0006035_abnormal_mitochondrial_morpho0.67952148
86MP0003186_abnormal_redox_activity0.66272904
87MP0003448_altered_tumor_morphology0.64680197
88MP0004043_abnormal_pH_regulation0.64498114
89MP0005319_abnormal_enzyme/_coenzyme0.64149937
90MP0009765_abnormal_xenobiotic_induced0.63982949
91MP0005332_abnormal_amino_acid0.63425405
92MP0003195_calcinosis0.61673569
93MP0000372_irregular_coat_pigmentation0.60192435
94MP0005410_abnormal_fertilization0.58725064
95MP0002933_joint_inflammation0.58573250
96MP0002019_abnormal_tumor_incidence0.58526821
97MP0003786_premature_aging0.57546470
98MP0005636_abnormal_mineral_homeostasis0.56705711
99MP0002396_abnormal_hematopoietic_system0.56260824
100MP0004019_abnormal_vitamin_homeostasis0.55596038

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.07549856
2Elevated erythrocyte sedimentation rate (HP:0003565)3.74279286
3Meningitis (HP:0001287)3.68638508
4Abnormality of the prostate (HP:0008775)3.61166910
5Vasculitis (HP:0002633)3.48705018
6Recurrent bacterial skin infections (HP:0005406)3.42474502
7Mediastinal lymphadenopathy (HP:0100721)3.39551329
8Abnormality of macrophages (HP:0004311)3.29815350
9Gastrointestinal stroma tumor (HP:0100723)3.29529800
10IgG deficiency (HP:0004315)3.24961827
11Pulmonary infiltrates (HP:0002113)3.22069231
12Chronic obstructive pulmonary disease (HP:0006510)3.17250920
13Obstructive lung disease (HP:0006536)3.17250920
14Recurrent abscess formation (HP:0002722)3.15225846
15Panhypogammaglobulinemia (HP:0003139)3.14812209
16Abnormality of glycolipid metabolism (HP:0010969)3.12582628
17Abnormality of liposaccharide metabolism (HP:0010968)3.12582628
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.12582628
19Recurrent fungal infections (HP:0002841)3.11815537
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.09323420
21Myositis (HP:0100614)3.04303273
22Vacuolated lymphocytes (HP:0001922)3.01495203
23Stomatitis (HP:0010280)2.99839912
24Eczematoid dermatitis (HP:0000976)2.99594438
25Optic neuritis (HP:0100653)2.98482370
26Retrobulbar optic neuritis (HP:0100654)2.98482370
27Systemic lupus erythematosus (HP:0002725)2.93269754
28Urticaria (HP:0001025)2.87621083
29Recurrent bronchitis (HP:0002837)2.85234343
30Recurrent viral infections (HP:0004429)2.83943957
31Chronic mucocutaneous candidiasis (HP:0002728)2.79364197
32Recurrent cutaneous fungal infections (HP:0011370)2.79364197
33Orchitis (HP:0100796)2.78160571
34Abnormality of B cell number (HP:0010975)2.74780163
35Hemoptysis (HP:0002105)2.69250891
363-Methylglutaconic aciduria (HP:0003535)2.68377468
37Recurrent sinusitis (HP:0011108)2.68376172
38Recurrent skin infections (HP:0001581)2.61411348
39Pulmonary fibrosis (HP:0002206)2.60482458
40Autoimmune thrombocytopenia (HP:0001973)2.60405808
41Chest pain (HP:0100749)2.58102826
42Abnormality of T cell physiology (HP:0011840)2.51688195
43Pustule (HP:0200039)2.49224135
44Osteomyelitis (HP:0002754)2.48017761
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47871044
46Dysostosis multiplex (HP:0000943)2.46996012
47Eosinophilia (HP:0001880)2.44436913
48IgM deficiency (HP:0002850)2.43243945
49Encephalitis (HP:0002383)2.40588757
50Increased serum ferritin (HP:0003281)2.38695680
51Abnormality of transition element cation homeostasis (HP:0011030)2.38293930
52Chronic diarrhea (HP:0002028)2.37067883
53Xerostomia (HP:0000217)2.36869144
54Abnormality of T cells (HP:0002843)2.36827391
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35900352
56Skin rash (HP:0000988)2.33837620
57Granulocytopenia (HP:0001913)2.33780107
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.33754449
59Microvesicular hepatic steatosis (HP:0001414)2.32768131
60Abnormality of the pleura (HP:0002103)2.31505252
61Chronic otitis media (HP:0000389)2.31494663
62Prostate neoplasm (HP:0100787)2.30917932
63Recurrent gram-negative bacterial infections (HP:0005420)2.29047013
64Stomach cancer (HP:0012126)2.28010628
65Restrictive lung disease (HP:0002091)2.27307401
66IgA deficiency (HP:0002720)2.25186405
67B lymphocytopenia (HP:0010976)2.25003741
68Recurrent pneumonia (HP:0006532)2.24625021
69Increased cerebral lipofuscin (HP:0011813)2.23926581
70Hypertensive crisis (HP:0100735)2.22484952
71Lymphopenia (HP:0001888)2.22076155
72Abnormality of iron homeostasis (HP:0011031)2.21125523
73Lipid accumulation in hepatocytes (HP:0006561)2.17047526
74Polyneuropathy (HP:0001271)2.16692867
75Gangrene (HP:0100758)2.16534773
76Petechiae (HP:0000967)2.15202488
77Cellulitis (HP:0100658)2.15133832
78Arthralgia (HP:0002829)2.14596242
79Abnormality of T cell number (HP:0011839)2.13104404
80Increased hepatocellular lipid droplets (HP:0006565)2.10602030
81Verrucae (HP:0200043)2.09334778
82Papilloma (HP:0012740)2.09334778
83Keratoconjunctivitis (HP:0001096)2.09206345
84Exertional dyspnea (HP:0002875)2.09106856
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.07901380
86Joint swelling (HP:0001386)2.03618928
87Chronic sinusitis (HP:0011109)2.02616874
88Abnormality of eosinophils (HP:0001879)2.02305589
89Keratoconjunctivitis sicca (HP:0001097)2.01643975
90Recurrent lower respiratory tract infections (HP:0002783)2.01030431
91Hepatocellular necrosis (HP:0001404)2.00999406
92Gastrointestinal infarctions (HP:0005244)2.00483957
93Leukocytosis (HP:0001974)1.98902957
94Arterial thrombosis (HP:0004420)1.98888572
95Neutropenia (HP:0001875)1.98573372
96Epistaxis (HP:0000421)1.98256340
97Increased intramyocellular lipid droplets (HP:0012240)1.97454407
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97448843
99Mitochondrial inheritance (HP:0001427)1.97422394
100Pulmonary embolism (HP:0002204)1.94564003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.64229364
2TLK13.14956662
3KIT3.11586806
4TXK3.07098637
5MAP4K12.86284549
6BMPR22.76120548
7RIPK42.72921320
8CSF1R2.49525228
9IKBKB2.19641566
10TIE12.19163496
11SYK2.19121252
12MAP3K142.16261754
13MST42.00672092
14TBK11.97724340
15EIF2AK31.94083166
16BLK1.88494897
17TEC1.87414229
18OXSR11.83965701
19IKBKE1.80440168
20JAK31.74144904
21FES1.70432577
22ZAK1.68408178
23PINK11.68157576
24GRK61.65469578
25BTK1.62862252
26BCKDK1.59646780
27MATK1.57634521
28LYN1.56006373
29MAP3K121.55082145
30KDR1.54576202
31TYK21.50788229
32VRK21.44827012
33ERN11.43511468
34ITK1.39895650
35GRK11.39403070
36EIF2AK11.36149496
37CDK191.33074439
38IRAK41.30925506
39PIK3CG1.28076169
40NME21.22414444
41JAK11.19956537
42CSK1.19522469
43NUAK11.16758558
44VRK11.13507943
45ADRBK21.11063699
46STK161.08583630
47LCK1.07166153
48DAPK11.06500007
49GRK71.06395685
50TESK20.99500040
51HCK0.97811253
52BMPR1B0.90958801
53DAPK30.90350951
54CHUK0.84632214
55PRKCQ0.80939082
56ZAP700.79317513
57MAP2K20.78058948
58MAPKAPK30.77793778
59STK100.77058764
60RPS6KA50.76591673
61MAPK110.76227011
62TRPM70.75861899
63STK390.74456234
64JAK20.70266791
65TGFBR20.69876531
66FGR0.69847093
67EIF2AK20.67814962
68ABL10.66557097
69IGF1R0.65511424
70TNK20.61842082
71PIM10.61236061
72ACVR1B0.58756327
73WNK40.56857552
74DAPK20.54647678
75FLT30.54028086
76PRKG20.51901664
77CDK80.50900695
78PIM20.50144815
79PDK20.49842004
80MARK30.49038834
81MYLK0.48149957
82GRK50.48127922
83PRKCD0.46222476
84CCNB10.44006141
85MAPKAPK50.43600710
86MUSK0.39043632
87EGFR0.38574755
88MAP3K130.37778892
89TGFBR10.37561301
90FRK0.35292149
91PDK10.34304670
92INSRR0.33245720
93PTK2B0.32207422
94CDK90.28618787
95PRKCI0.28557557
96MAPKAPK20.27311504
97ABL20.25644064
98FER0.25426350
99MAP2K60.24979973
100INSR0.24906666

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.78157473
2Allograft rejection_Homo sapiens_hsa053305.16615010
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.82259374
4Graft-versus-host disease_Homo sapiens_hsa053324.80708695
5Autoimmune thyroid disease_Homo sapiens_hsa053204.80222032
6Type I diabetes mellitus_Homo sapiens_hsa049404.11836768
7Staphylococcus aureus infection_Homo sapiens_hsa051503.41980704
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.03453656
9Antigen processing and presentation_Homo sapiens_hsa046123.03302892
10Viral myocarditis_Homo sapiens_hsa054162.76746299
11Leishmaniasis_Homo sapiens_hsa051402.68956403
12Rheumatoid arthritis_Homo sapiens_hsa053232.57554603
13Primary immunodeficiency_Homo sapiens_hsa053401.83721940
14Systemic lupus erythematosus_Homo sapiens_hsa053221.80608755
15Tuberculosis_Homo sapiens_hsa051521.42055643
16Hematopoietic cell lineage_Homo sapiens_hsa046401.40544258
17Herpes simplex infection_Homo sapiens_hsa051681.38031542
18Toxoplasmosis_Homo sapiens_hsa051451.34824137
19Other glycan degradation_Homo sapiens_hsa005111.30368421
20Influenza A_Homo sapiens_hsa051641.28065637
21Proteasome_Homo sapiens_hsa030501.23277155
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16274945
23Phagosome_Homo sapiens_hsa041451.08164048
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.03309481
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99467398
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94875768
27B cell receptor signaling pathway_Homo sapiens_hsa046620.88313485
28Osteoclast differentiation_Homo sapiens_hsa043800.81990477
29Lysosome_Homo sapiens_hsa041420.79810427
30NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75126636
31Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74689624
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74111034
33Epstein-Barr virus infection_Homo sapiens_hsa051690.73784997
34Legionellosis_Homo sapiens_hsa051340.71606353
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63555959
36Linoleic acid metabolism_Homo sapiens_hsa005910.62179848
37Pertussis_Homo sapiens_hsa051330.59680910
38Sulfur metabolism_Homo sapiens_hsa009200.56937194
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56369589
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53182086
41Measles_Homo sapiens_hsa051620.52386467
42Fat digestion and absorption_Homo sapiens_hsa049750.50199515
43Collecting duct acid secretion_Homo sapiens_hsa049660.49457964
44Oxidative phosphorylation_Homo sapiens_hsa001900.48292748
45Vitamin digestion and absorption_Homo sapiens_hsa049770.47506563
46Arachidonic acid metabolism_Homo sapiens_hsa005900.47131832
47Tryptophan metabolism_Homo sapiens_hsa003800.47081693
48African trypanosomiasis_Homo sapiens_hsa051430.45018198
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.43532628
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.42442806
51Mineral absorption_Homo sapiens_hsa049780.41099062
52Malaria_Homo sapiens_hsa051440.39667753
53TNF signaling pathway_Homo sapiens_hsa046680.39098035
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38527554
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38272063
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33730057
57Ether lipid metabolism_Homo sapiens_hsa005650.33627703
58HTLV-I infection_Homo sapiens_hsa051660.32960319
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31540953
60Chemokine signaling pathway_Homo sapiens_hsa040620.30823585
61Caffeine metabolism_Homo sapiens_hsa002320.28023009
62Parkinsons disease_Homo sapiens_hsa050120.27102368
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26937169
64Chemical carcinogenesis_Homo sapiens_hsa052040.26302659
65Nitrogen metabolism_Homo sapiens_hsa009100.25843715
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25726052
67Shigellosis_Homo sapiens_hsa051310.24813773
68Salmonella infection_Homo sapiens_hsa051320.22452702
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19261397
70T cell receptor signaling pathway_Homo sapiens_hsa046600.18425305
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.17897646
72Protein export_Homo sapiens_hsa030600.17797558
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16707616
74Phototransduction_Homo sapiens_hsa047440.16684336
75Sphingolipid metabolism_Homo sapiens_hsa006000.15712690
76RNA degradation_Homo sapiens_hsa030180.14606360
77Apoptosis_Homo sapiens_hsa042100.13502959
78Hepatitis C_Homo sapiens_hsa051600.13392221
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13287046
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12901513
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12458419
82Pentose phosphate pathway_Homo sapiens_hsa000300.12109077
83Peroxisome_Homo sapiens_hsa041460.10607561
84Viral carcinogenesis_Homo sapiens_hsa052030.10038814
85Platelet activation_Homo sapiens_hsa046110.09070256
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08761802
87Glutathione metabolism_Homo sapiens_hsa004800.07771689
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.06704063
89Ribosome_Homo sapiens_hsa030100.06251885
90Propanoate metabolism_Homo sapiens_hsa006400.06135356
91Renin-angiotensin system_Homo sapiens_hsa046140.05337491
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.05253187
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.04676467
94Regulation of autophagy_Homo sapiens_hsa041400.04476530
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04467181
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.03957360
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.03576942
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02467984
99Hepatitis B_Homo sapiens_hsa051610.02306008
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.01986722

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