HLA-DRB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.78592278
2B cell mediated immunity (GO:0019724)6.29810536
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.81413819
4interferon-gamma-mediated signaling pathway (GO:0060333)5.80112475
5positive regulation of antigen processing and presentation (GO:0002579)5.52457326
6regulation of antigen processing and presentation (GO:0002577)5.37426708
7positive thymic T cell selection (GO:0045059)4.87893240
8antigen processing and presentation of endogenous antigen (GO:0019883)4.47665109
9cellular response to interferon-gamma (GO:0071346)4.44765229
10T cell costimulation (GO:0031295)4.32803406
11lymphocyte costimulation (GO:0031294)4.27333212
12regulation of dendritic cell antigen processing and presentation (GO:0002604)4.24058440
13detection of bacterium (GO:0016045)4.09849179
14negative regulation of B cell apoptotic process (GO:0002903)4.05472847
15production of molecular mediator of immune response (GO:0002440)4.05230114
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.89056564
17response to interferon-gamma (GO:0034341)3.88587655
18chaperone mediated protein folding requiring cofactor (GO:0051085)3.86969707
19neutrophil activation involved in immune response (GO:0002283)3.85104766
20detection of other organism (GO:0098543)3.78834559
21positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.72728638
22purine deoxyribonucleotide catabolic process (GO:0009155)3.71513143
23regulation of B cell apoptotic process (GO:0002902)3.70279861
24positive T cell selection (GO:0043368)3.69195728
25mast cell activation (GO:0045576)3.68842324
26regulation of B cell receptor signaling pathway (GO:0050855)3.68815362
27DNA deamination (GO:0045006)3.65242745
28regulation of germinal center formation (GO:0002634)3.64282440
29negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.62642238
30growth hormone receptor signaling pathway (GO:0060396)3.58449163
31antigen receptor-mediated signaling pathway (GO:0050851)3.48550825
32positive regulation of type 2 immune response (GO:0002830)3.46241762
33T-helper 1 type immune response (GO:0042088)3.45249353
34negative regulation of mast cell activation (GO:0033004)3.44145699
35regulation of hypersensitivity (GO:0002883)3.40683938
36T cell receptor signaling pathway (GO:0050852)3.38731476
37mature B cell differentiation involved in immune response (GO:0002313)3.35348531
38response to interferon-beta (GO:0035456)3.32797394
39positive regulation of macrophage cytokine production (GO:0060907)3.30792461
40cellular response to growth hormone stimulus (GO:0071378)3.20268230
41cell wall macromolecule metabolic process (GO:0044036)3.19721167
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.19041981
43mast cell activation involved in immune response (GO:0002279)3.17730456
44mast cell degranulation (GO:0043303)3.17730456
45regulation of inflammatory response to antigenic stimulus (GO:0002861)3.17688090
46regulation of T-helper 1 cell differentiation (GO:0045625)3.17307318
47negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.14277518
48regulation of mast cell activation (GO:0033003)3.13519036
49response to peptidoglycan (GO:0032494)3.07411371
50B cell receptor signaling pathway (GO:0050853)2.98804852
51purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.97811423
52positive regulation of T-helper 1 type immune response (GO:0002827)2.96531437
53regulation of alpha-beta T cell proliferation (GO:0046640)2.94662224
54adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.94352956
55negative thymic T cell selection (GO:0045060)2.93441271
56tryptophan metabolic process (GO:0006568)2.92268264
57positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92251680
58antigen processing and presentation via MHC class Ib (GO:0002475)2.91567664
59positive regulation of prostaglandin secretion (GO:0032308)2.91146666
60regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.89491942
61mature B cell differentiation (GO:0002335)2.87826046
62positive regulation of gamma-delta T cell activation (GO:0046645)2.85744318
63detection of external biotic stimulus (GO:0098581)2.82550195
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76794224
65negative T cell selection (GO:0043383)2.75751727
66positive regulation of interferon-gamma production (GO:0032729)2.74244487
67positive regulation of T cell activation (GO:0050870)2.74080085
68tyrosine phosphorylation of STAT protein (GO:0007260)2.73586052
69cell wall macromolecule catabolic process (GO:0016998)2.71003670
70purine deoxyribonucleotide metabolic process (GO:0009151)2.69684671
71positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.68238526
72positive regulation of interleukin-1 beta production (GO:0032731)2.67503033
73response to muramyl dipeptide (GO:0032495)2.66234479
74positive regulation of mast cell activation (GO:0033005)2.65925682
75myeloid cell activation involved in immune response (GO:0002275)2.65620822
76positive regulation of B cell proliferation (GO:0030890)2.64139706
77indole-containing compound catabolic process (GO:0042436)2.63241591
78indolalkylamine catabolic process (GO:0046218)2.63241591
79tryptophan catabolic process (GO:0006569)2.63241591
80positive regulation of B cell differentiation (GO:0045579)2.62387974
81detection of biotic stimulus (GO:0009595)2.61395178
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61023815
83positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60716313
84leukocyte degranulation (GO:0043299)2.60385874
85positive regulation of interleukin-1 beta secretion (GO:0050718)2.59834479
86regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.59520060
87positive regulation of T cell proliferation (GO:0042102)2.59475138
88regulation of T-helper 1 type immune response (GO:0002825)2.58674892
89adaptive immune response (GO:0002250)2.57861951
90thymic T cell selection (GO:0045061)2.57828285
91positive regulation of mast cell degranulation (GO:0043306)2.56216091
92positive regulation of mast cell activation involved in immune response (GO:0033008)2.56216091
93antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.56149088
94antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.56149088
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55491936
96positive regulation of interleukin-17 production (GO:0032740)2.54721160
97antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.54165360
98T cell selection (GO:0045058)2.52178144
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49992989
100actin nucleation (GO:0045010)2.49991946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.48731293
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.65043047
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.72275258
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.88217197
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.70102503
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.67232249
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.24005566
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.20947320
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88673317
10CIITA_25753668_ChIP-Seq_RAJI_Human2.73011702
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70619452
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54545194
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51601418
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.23233950
15MYB_26560356_Chip-Seq_TH2_Human2.22037292
16SPI1_23547873_ChIP-Seq_NB4_Human2.18914007
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01410993
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92362126
19GATA3_26560356_Chip-Seq_TH2_Human1.91756217
20VDR_23849224_ChIP-Seq_CD4+_Human1.87682508
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81748085
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81092521
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80200599
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79309381
25SCL_19346495_ChIP-Seq_HPC-7_Human1.79221732
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.72084665
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60203884
28ZNF274_21170338_ChIP-Seq_K562_Hela1.60036383
29GATA1_22025678_ChIP-Seq_K562_Human1.58230318
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56680954
31GATA3_27048872_Chip-Seq_THYMUS_Human1.56436396
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50256454
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.47987623
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46477252
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44976842
36MYB_26560356_Chip-Seq_TH1_Human1.41358528
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39823910
38IRF1_19129219_ChIP-ChIP_H3396_Human1.39706119
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35978236
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33342188
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33075786
42FOXP3_21729870_ChIP-Seq_TREG_Human1.32995997
43STAT1_20625510_ChIP-Seq_HELA_Human1.32707033
44TAF2_19829295_ChIP-Seq_ESCs_Human1.30582641
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30542896
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26085094
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.25427167
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.24885419
49ELK1_19687146_ChIP-ChIP_HELA_Human1.24709585
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24123508
51RUNX_20019798_ChIP-Seq_JUKART_Human1.23748381
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21263023
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19869210
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.19869210
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19485348
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19144908
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19120842
58IGF1R_20145208_ChIP-Seq_DFB_Human1.18704481
59AR_20517297_ChIP-Seq_VCAP_Human1.18516073
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.17397158
61SPI1_23127762_ChIP-Seq_K562_Human1.15109643
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12611164
63SOX2_19829295_ChIP-Seq_ESCs_Human1.12312977
64NANOG_19829295_ChIP-Seq_ESCs_Human1.12312977
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10741373
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09965049
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07975112
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07962155
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06321545
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05808542
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05801326
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03324921
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03306678
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01253986
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.00829253
76BCL6_27268052_Chip-Seq_Bcells_Human1.00066727
77GATA3_26560356_Chip-Seq_TH1_Human0.98227551
78VDR_24787735_ChIP-Seq_THP-1_Human0.97054012
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96992293
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95080136
81MYC_18940864_ChIP-ChIP_HL60_Human0.92638003
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92589286
83VDR_24763502_ChIP-Seq_THP-1_Human0.92221101
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91673709
85MAF_26560356_Chip-Seq_TH1_Human0.91480838
86P300_27268052_Chip-Seq_Bcells_Human0.91046706
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90883517
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89997668
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89314141
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88965142
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88697861
92ERG_20517297_ChIP-Seq_VCAP_Human0.88696015
93VDR_22108803_ChIP-Seq_LS180_Human0.87622920
94TP53_22573176_ChIP-Seq_HFKS_Human0.86494249
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84310665
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83687529
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82328125
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81894097
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81478346
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81403520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.57529890
2MP0002138_abnormal_hepatobiliary_system4.72486778
3MP0003724_increased_susceptibility_to3.70890526
4MP0005671_abnormal_response_to3.42404776
5MP0001800_abnormal_humoral_immune3.08629579
6MP0000685_abnormal_immune_system2.91157899
7MP0002166_altered_tumor_susceptibility2.84486488
8MP0005000_abnormal_immune_tolerance2.84410290
9MP0009785_altered_susceptibility_to2.84203468
10MP0002148_abnormal_hypersensitivity_rea2.80151875
11MP0003806_abnormal_nucleotide_metabolis2.56061075
12MP0003436_decreased_susceptibility_to2.49270459
13MP0002452_abnormal_antigen_presenting2.46924707
14MP0002723_abnormal_immune_serum2.36031449
15MP0001790_abnormal_immune_system2.32202688
16MP0005387_immune_system_phenotype2.32202688
17MP0002006_tumorigenesis2.23243735
18MP0002420_abnormal_adaptive_immunity2.11132054
19MP0001819_abnormal_immune_cell2.09165120
20MP0002419_abnormal_innate_immunity2.01387727
21MP0005025_abnormal_response_to1.98141302
22MP0009764_decreased_sensitivity_to1.96799606
23MP0010155_abnormal_intestine_physiology1.83735662
24MP0005397_hematopoietic_system_phenotyp1.79556391
25MP0001545_abnormal_hematopoietic_system1.79556391
26MP0008875_abnormal_xenobiotic_pharmacok1.76225414
27MP0005075_abnormal_melanosome_morpholog1.73495232
28MP0002398_abnormal_bone_marrow1.64670639
29MP0000716_abnormal_immune_system1.63273357
30MP0005084_abnormal_gallbladder_morpholo1.62948461
31MP0003183_abnormal_peptide_metabolism1.59662029
32MP0005464_abnormal_platelet_physiology1.59147633
33MP0005645_abnormal_hypothalamus_physiol1.50846126
34MP0009278_abnormal_bone_marrow1.48793842
35MP0001845_abnormal_inflammatory_respons1.48232569
36MP0003866_abnormal_defecation1.47693752
37MP0008872_abnormal_physiological_respon1.46725076
38MP0004147_increased_porphyrin_level1.46003433
39MP0009333_abnormal_splenocyte_physiolog1.40314976
40MP0001853_heart_inflammation1.39293125
41MP0006054_spinal_hemorrhage1.36523263
42MP0001533_abnormal_skeleton_physiology1.36284994
43MP0003075_altered_response_to1.32915157
44MP0002429_abnormal_blood_cell1.30888985
45MP0005167_abnormal_blood-brain_barrier1.30460559
46MP0003303_peritoneal_inflammation1.30405925
47MP0000689_abnormal_spleen_morphology1.28994090
48MP0002139_abnormal_hepatobiliary_system1.25631626
49MP0008469_abnormal_protein_level1.24972551
50MP0005367_renal/urinary_system_phenotyp1.23168779
51MP0000516_abnormal_urinary_system1.23168779
52MP0002405_respiratory_system_inflammati1.21856360
53MP0006082_CNS_inflammation1.21447894
54MP0003646_muscle_fatigue1.20023972
55MP0000569_abnormal_digit_pigmentation1.18819133
56MP0003763_abnormal_thymus_physiology1.16352782
57MP0002722_abnormal_immune_system1.11893931
58MP0006036_abnormal_mitochondrial_physio1.08126986
59MP0004145_abnormal_muscle_electrophysio1.06488562
60MP0005166_decreased_susceptibility_to1.06402416
61MP0004947_skin_inflammation1.05523341
62MP0003172_abnormal_lysosome_physiology1.05190244
63MP0000013_abnormal_adipose_tissue1.01230013
64MP0005360_urolithiasis1.00142031
65MP0009643_abnormal_urine_homeostasis0.95461535
66MP0002396_abnormal_hematopoietic_system0.94488193
67MP0005085_abnormal_gallbladder_physiolo0.90836832
68MP0000465_gastrointestinal_hemorrhage0.90306416
69MP0001873_stomach_inflammation0.89473441
70MP0002876_abnormal_thyroid_physiology0.86788806
71MP0005646_abnormal_pituitary_gland0.85665238
72MP0002132_abnormal_respiratory_system0.85078536
73MP0000858_altered_metastatic_potential0.82692029
74MP0005165_increased_susceptibility_to0.78380095
75MP0003252_abnormal_bile_duct0.76432736
76MP0003300_gastrointestinal_ulcer0.75864720
77MP0002019_abnormal_tumor_incidence0.75681236
78MP0000372_irregular_coat_pigmentation0.73099645
79MP0009763_increased_sensitivity_to0.72489745
80MP0005410_abnormal_fertilization0.68170081
81MP0003186_abnormal_redox_activity0.67761570
82MP0000249_abnormal_blood_vessel0.67440896
83MP0005220_abnormal_exocrine_pancreas0.66576748
84MP0005332_abnormal_amino_acid0.66298536
85MP0005535_abnormal_body_temperature0.66136783
86MP0004808_abnormal_hematopoietic_stem0.65406105
87MP0000703_abnormal_thymus_morphology0.65207094
88MP0006035_abnormal_mitochondrial_morpho0.65029740
89MP0005174_abnormal_tail_pigmentation0.64925371
90MP0004043_abnormal_pH_regulation0.64861269
91MP0002136_abnormal_kidney_physiology0.63976109
92MP0000230_abnormal_systemic_arterial0.63734568
93MP0005319_abnormal_enzyme/_coenzyme0.62930201
94MP0001968_abnormal_touch/_nociception0.62489379
95MP0008873_increased_physiological_sensi0.59372687
96MP0004782_abnormal_surfactant_physiolog0.59243545
97MP0001542_abnormal_bone_strength0.56287209
98MP0001501_abnormal_sleep_pattern0.55869420
99MP0005390_skeleton_phenotype0.55687478
100MP0005636_abnormal_mineral_homeostasis0.55205791

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.96494610
2Abnormality of the prostate (HP:0008775)4.99421707
3Meningitis (HP:0001287)3.76251566
4Agammaglobulinemia (HP:0004432)3.70431146
5Chest pain (HP:0100749)3.53097827
6Vasculitis (HP:0002633)3.51983649
7Gastrointestinal infarctions (HP:0005244)3.45990502
8Panhypogammaglobulinemia (HP:0003139)3.44700020
9Pulmonary infiltrates (HP:0002113)3.31141650
10Myositis (HP:0100614)3.29239922
11Decreased electroretinogram (ERG) amplitude (HP:0000654)3.22325464
12Mediastinal lymphadenopathy (HP:0100721)3.11365771
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.07837835
14Prostate neoplasm (HP:0100787)3.05301231
15Abnormality of the pleura (HP:0002103)3.04931482
16Chronic obstructive pulmonary disease (HP:0006510)2.97171793
17Obstructive lung disease (HP:0006536)2.97171793
18Optic neuritis (HP:0100653)2.93148200
19Retrobulbar optic neuritis (HP:0100654)2.93148200
20Exertional dyspnea (HP:0002875)2.90073886
21Urticaria (HP:0001025)2.87718385
22Abnormality of male internal genitalia (HP:0000022)2.85721352
23Hemoptysis (HP:0002105)2.82563345
24Congenital, generalized hypertrichosis (HP:0004540)2.78218538
25Orchitis (HP:0100796)2.73234249
26Pulmonary fibrosis (HP:0002206)2.72019812
27Gangrene (HP:0100758)2.62321552
28Arterial thrombosis (HP:0004420)2.59844405
29Hepatocellular necrosis (HP:0001404)2.59007797
30Pulmonary embolism (HP:0002204)2.58343559
31Decreased central vision (HP:0007663)2.55217274
32Hepatic necrosis (HP:0002605)2.54076551
33Recurrent bacterial skin infections (HP:0005406)2.53420402
34Alveolar cell carcinoma (HP:0006519)2.52023626
35Chronic mucocutaneous candidiasis (HP:0002728)2.49168263
36Recurrent cutaneous fungal infections (HP:0011370)2.49168263
37Type 2 muscle fiber atrophy (HP:0003554)2.48549455
38Encephalitis (HP:0002383)2.45717569
39Acute hepatic failure (HP:0006554)2.45558869
40Recurrent abscess formation (HP:0002722)2.43663943
41Abnormality of B cell number (HP:0010975)2.43448573
42IgG deficiency (HP:0004315)2.42970205
43Abnormality of T cell physiology (HP:0011840)2.41905548
44Ureteral obstruction (HP:0006000)2.40349117
45Ureteral stenosis (HP:0000071)2.39667118
46Increased intramyocellular lipid droplets (HP:0012240)2.38614927
47Recurrent fungal infections (HP:0002841)2.38590884
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.38051395
49Mitochondrial inheritance (HP:0001427)2.35436422
50Increased hepatocellular lipid droplets (HP:0006565)2.34653276
51Skin rash (HP:0000988)2.32832504
52Hypoproteinemia (HP:0003075)2.31683333
53Stomatitis (HP:0010280)2.31170647
54Amaurosis fugax (HP:0100576)2.30026169
553-Methylglutaconic aciduria (HP:0003535)2.29142917
56Chronic otitis media (HP:0000389)2.28355157
57Abolished electroretinogram (ERG) (HP:0000550)2.28151499
58IgM deficiency (HP:0002850)2.28003245
59Increased CSF lactate (HP:0002490)2.25488972
60Abnormality of the peritoneum (HP:0002585)2.25284963
61Recurrent sinusitis (HP:0011108)2.24261806
62Fatigue (HP:0012378)2.23288992
63Stomach cancer (HP:0012126)2.21614937
64Lipid accumulation in hepatocytes (HP:0006561)2.18876653
65Hypothermia (HP:0002045)2.18050210
66Chronic diarrhea (HP:0002028)2.17152621
67Dry hair (HP:0011359)2.16832920
68Xerostomia (HP:0000217)2.15023832
69Recurrent bronchitis (HP:0002837)2.14618894
70Neoplasm of the tracheobronchial system (HP:0100552)2.10730145
71Recurrent skin infections (HP:0001581)2.10271650
72Chronic sinusitis (HP:0011109)2.10039643
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09563472
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09563472
75Abnormality of T cells (HP:0002843)2.09511825
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07388374
77Acute necrotizing encephalopathy (HP:0006965)2.06939928
78Increased muscle lipid content (HP:0009058)2.02040973
79Muscle fiber atrophy (HP:0100295)2.01212238
80Abnormal mitochondria in muscle tissue (HP:0008316)2.00246330
81Congenital stationary night blindness (HP:0007642)1.99256564
82Thrombophlebitis (HP:0004418)1.98889001
83Facial diplegia (HP:0001349)1.98522987
84Cerebral ischemia (HP:0002637)1.98424908
85Cerebral hemorrhage (HP:0001342)1.98186566
86Progressive macrocephaly (HP:0004481)1.97781084
87Polyneuropathy (HP:0001271)1.96903856
88Recurrent viral infections (HP:0004429)1.94287889
89Increased cerebral lipofuscin (HP:0011813)1.93464750
90Keratoconjunctivitis sicca (HP:0001097)1.93353855
91Petechiae (HP:0000967)1.92286562
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91485582
93Glomerulopathy (HP:0100820)1.89600607
94Lactic acidosis (HP:0003128)1.89229973
95Increased serum lactate (HP:0002151)1.89073035
96Restrictive lung disease (HP:0002091)1.86776991
97B lymphocytopenia (HP:0010976)1.85855677
98Gastrointestinal stroma tumor (HP:0100723)1.85590838
99Amyloidosis (HP:0011034)1.84804596
100Keratoconjunctivitis (HP:0001096)1.83223258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.11712057
2BMPR23.92042600
3TLK13.87449384
4KIT3.28983359
5CDK193.14208166
6ZAK2.72576403
7MAP4K12.51224533
8BCKDK2.37456485
9CDK82.35502121
10MAP3K142.30095605
11CSF1R2.22500610
12JAK32.10909838
13MAP4K21.99136365
14SYK1.97914220
15RIPK41.96598500
16BMPR1B1.92029954
17IKBKB1.91092770
18FRK1.89092147
19TEC1.85632258
20MST41.80811306
21TXK1.74488990
22FES1.68259355
23EIF2AK31.58807212
24TBK11.56107231
25FLT31.53248401
26IKBKE1.51790658
27BTK1.51727889
28TRPM71.49771258
29OXSR11.48389180
30PIK3CG1.47926011
31VRK11.47021846
32TIE11.43734942
33KDR1.38825204
34ITK1.36071534
35GRK11.33415226
36NUAK11.33032032
37LYN1.28026020
38ADRBK21.26780631
39ERBB31.22883266
40VRK21.21966765
41MAP3K131.12838704
42IRAK41.11370574
43GRK61.10240084
44SCYL21.00217933
45BLK0.99104139
46RPS6KA50.97785992
47TGFBR10.96674106
48LCK0.95733962
49MAP3K120.91935912
50HCK0.88756635
51CHUK0.86827762
52MAPKAPK50.84568665
53MAPKAPK30.84213005
54DAPK30.84096809
55PINK10.75517213
56TYK20.75043018
57WNK40.74558867
58CSNK1G30.74549455
59ABL10.72121459
60MAP2K20.67215007
61DAPK10.65252078
62MKNK10.63888130
63JAK10.60209677
64IGF1R0.60200889
65PRKCQ0.55566295
66EGFR0.54659304
67ZAP700.52248792
68EIF2AK20.52147156
69MATK0.51911078
70CSNK1G20.51876534
71CCNB10.50269271
72JAK20.48151580
73PIM10.47038028
74MARK30.46920520
75TNK20.44703958
76INSRR0.44676709
77CSNK1A1L0.43670646
78MYLK0.43174172
79NME20.41828473
80TAF10.41762528
81PRKCD0.39475599
82SIK30.37000630
83CDK90.36299270
84MAP3K60.34923393
85GRK70.33943144
86PDK10.33329138
87CSNK1G10.33006410
88PHKG10.31898633
89PHKG20.31898633
90MAPK70.31867649
91CSK0.31717791
92PLK20.29996774
93ADRBK10.29569658
94DAPK20.28728937
95GRK50.27606459
96ERN10.26971623
97RPS6KB20.26914075
98STK38L0.26517395
99PKN10.26397864
100MAPK110.23578579

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.30802753
2Allograft rejection_Homo sapiens_hsa053305.34182620
3Autoimmune thyroid disease_Homo sapiens_hsa053205.03956335
4Graft-versus-host disease_Homo sapiens_hsa053324.96667291
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.76434945
6Type I diabetes mellitus_Homo sapiens_hsa049404.35475644
7Staphylococcus aureus infection_Homo sapiens_hsa051503.19371823
8Viral myocarditis_Homo sapiens_hsa054163.05114895
9Antigen processing and presentation_Homo sapiens_hsa046123.02925620
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.97057870
11Leishmaniasis_Homo sapiens_hsa051402.85051935
12Systemic lupus erythematosus_Homo sapiens_hsa053222.62329040
13Rheumatoid arthritis_Homo sapiens_hsa053232.31332567
14Toxoplasmosis_Homo sapiens_hsa051451.43220399
15Tuberculosis_Homo sapiens_hsa051521.42158049
16Hematopoietic cell lineage_Homo sapiens_hsa046401.34812737
17Primary immunodeficiency_Homo sapiens_hsa053401.30738492
18Herpes simplex infection_Homo sapiens_hsa051681.24572586
19Influenza A_Homo sapiens_hsa051641.23978858
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16885760
21Proteasome_Homo sapiens_hsa030501.15863995
22Phagosome_Homo sapiens_hsa041450.93399431
23Oxidative phosphorylation_Homo sapiens_hsa001900.87846104
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85598393
25Phototransduction_Homo sapiens_hsa047440.80686675
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75866624
27Linoleic acid metabolism_Homo sapiens_hsa005910.73434727
28NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73250972
29Parkinsons disease_Homo sapiens_hsa050120.69168383
30One carbon pool by folate_Homo sapiens_hsa006700.67013533
31Epstein-Barr virus infection_Homo sapiens_hsa051690.62921757
32B cell receptor signaling pathway_Homo sapiens_hsa046620.62644763
33Alcoholism_Homo sapiens_hsa050340.60288994
34SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58292476
35Ribosome_Homo sapiens_hsa030100.57555373
36Arachidonic acid metabolism_Homo sapiens_hsa005900.53890660
37Tryptophan metabolism_Homo sapiens_hsa003800.50644835
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.48179795
39Protein export_Homo sapiens_hsa030600.43129198
40Legionellosis_Homo sapiens_hsa051340.42760379
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40832334
42Nitrogen metabolism_Homo sapiens_hsa009100.40226423
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39118069
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.37014501
45RNA degradation_Homo sapiens_hsa030180.36250976
46Homologous recombination_Homo sapiens_hsa034400.35383175
47Osteoclast differentiation_Homo sapiens_hsa043800.35155645
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34990948
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34194413
50Ether lipid metabolism_Homo sapiens_hsa005650.33252715
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32063724
52Alzheimers disease_Homo sapiens_hsa050100.31689579
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30607817
54Measles_Homo sapiens_hsa051620.30507793
55Fanconi anemia pathway_Homo sapiens_hsa034600.30344934
56Fatty acid elongation_Homo sapiens_hsa000620.29391965
57HTLV-I infection_Homo sapiens_hsa051660.29345189
58Olfactory transduction_Homo sapiens_hsa047400.28115227
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25585848
60Pertussis_Homo sapiens_hsa051330.25032512
61Propanoate metabolism_Homo sapiens_hsa006400.24095401
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23102734
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20829259
64Viral carcinogenesis_Homo sapiens_hsa052030.19328389
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19177079
66Shigellosis_Homo sapiens_hsa051310.18505312
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18300983
68Other glycan degradation_Homo sapiens_hsa005110.18292749
69Platelet activation_Homo sapiens_hsa046110.17427801
70Salmonella infection_Homo sapiens_hsa051320.17343713
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16582868
72Huntingtons disease_Homo sapiens_hsa050160.16367443
73Chemical carcinogenesis_Homo sapiens_hsa052040.15977751
74Lysosome_Homo sapiens_hsa041420.15825995
75African trypanosomiasis_Homo sapiens_hsa051430.15471220
76Sulfur metabolism_Homo sapiens_hsa009200.14413519
77Peroxisome_Homo sapiens_hsa041460.13722965
78Regulation of autophagy_Homo sapiens_hsa041400.12512559
79Nucleotide excision repair_Homo sapiens_hsa034200.12149037
80Collecting duct acid secretion_Homo sapiens_hsa049660.11833268
81RNA polymerase_Homo sapiens_hsa030200.08649283
82Purine metabolism_Homo sapiens_hsa002300.08380212
83T cell receptor signaling pathway_Homo sapiens_hsa046600.07435482
84Salivary secretion_Homo sapiens_hsa049700.07085264
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06718266
86Cardiac muscle contraction_Homo sapiens_hsa042600.06717000
87Base excision repair_Homo sapiens_hsa034100.06307366
88Non-homologous end-joining_Homo sapiens_hsa034500.06245032
89Caffeine metabolism_Homo sapiens_hsa002320.04992434
90Fat digestion and absorption_Homo sapiens_hsa049750.04819092
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04527784
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03868753
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.02877610
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02674081
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.02612585
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.01785960
97Basal transcription factors_Homo sapiens_hsa030220.01647782
98Retinol metabolism_Homo sapiens_hsa008300.01132493
99Pyrimidine metabolism_Homo sapiens_hsa00240-0.0174819
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0038409

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