ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide salvage (GO:0043173)	9.22377700
2	pyrimidine nucleoside salvage (GO:0043097)	9.10906959
3	pyrimidine-containing compound salvage (GO:0008655)	9.10906959
4	nucleoside salvage (GO:0043174)	8.75282133
5	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	7.74333978
6	UMP metabolic process (GO:0046049)	7.74333978
7	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	7.74333978
8	UMP biosynthetic process (GO:0006222)	7.74333978
9	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	6.84681002
10	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	6.40978985
11	pentose metabolic process (GO:0019321)	5.41089491
12	CTP metabolic process (GO:0046036)	5.16825908
13	CTP biosynthetic process (GO:0006241)	5.16825908
14	diterpenoid biosynthetic process (GO:0016102)	5.02067678
15	purine nucleotide salvage (GO:0032261)	4.98636694
16	pentose-phosphate shunt (GO:0006098)	4.80620574
17	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	4.78794425
18	positive regulation of antigen processing and presentation (GO:0002579)	4.77440521
19	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.62730092
20	AMP metabolic process (GO:0046033)	4.58341753
21	DNA deamination (GO:0045006)	4.46527383
22	immunoglobulin mediated immune response (GO:0016064)	4.38876358
23	regulation of antigen processing and presentation (GO:0002577)	4.37894165
24	cellular metabolic compound salvage (GO:0043094)	4.29674315
25	keratinocyte development (GO:0003334)	4.25576239
26	activation of NF-kappaB-inducing kinase activity (GO:0007250)	4.23693650
27	regulation of activation of Janus kinase activity (GO:0010533)	4.18633162
28	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.16768447
29	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.14213991
30	regulation of dendritic cell antigen processing and presentation (GO:0002604)	4.13235777
31	NADPH regeneration (GO:0006740)	4.12653443
32	response to folic acid (GO:0051593)	4.10786531
33	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.98590730
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.98300012
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.98300012
36	negative regulation of JAK-STAT cascade (GO:0046426)	3.94782229
37	negative thymic T cell selection (GO:0045060)	3.83755656
38	interferon-gamma-mediated signaling pathway (GO:0060333)	3.81347063
39	DNA dealkylation (GO:0035510)	3.80621942
40	positive thymic T cell selection (GO:0045059)	3.70195142
41	response to interferon-beta (GO:0035456)	3.69033778
42	negative T cell selection (GO:0043383)	3.62349556
43	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.61727997
44	glucose catabolic process (GO:0006007)	3.61063189
45	terpenoid biosynthetic process (GO:0016114)	3.53346989
46	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.44144416
47	B cell mediated immunity (GO:0019724)	3.40306091
48	regulation of hypersensitivity (GO:0002883)	3.40208952
49	DNA ligation (GO:0006266)	3.39872846
50	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.38444801
51	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.37089863
52	neutrophil activation involved in immune response (GO:0002283)	3.34655943
53	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.33214338
54	cellular response to interferon-beta (GO:0035458)	3.32748212
55	positive regulation of NIK/NF-kappaB signaling (GO:1901224)	3.30915277
56	regulation of glycogen (starch) synthase activity (GO:2000465)	3.29107310
57	translational elongation (GO:0006414)	3.28061006
58	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.26928732
59	grooming behavior (GO:0007625)	3.23743239
60	viral transcription (GO:0019083)	3.17575011
61	T cell costimulation (GO:0031295)	3.16653141
62	cytidine metabolic process (GO:0046087)	3.12840266
63	cytidine catabolic process (GO:0006216)	3.12840266
64	cytidine deamination (GO:0009972)	3.12840266
65	lymphocyte costimulation (GO:0031294)	3.12764700
66	retinal metabolic process (GO:0042574)	3.12755024
67	thymic T cell selection (GO:0045061)	3.08369236
68	translational termination (GO:0006415)	3.04568744
69	cardiolipin metabolic process (GO:0032048)	2.99515625
70	negative regulation of B cell apoptotic process (GO:0002903)	2.99349996
71	neutrophil mediated immunity (GO:0002446)	2.98220121
72	mammary gland epithelial cell differentiation (GO:0060644)	2.96886782
73	cellular response to interferon-gamma (GO:0071346)	2.96426478
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.95029412
75	interleukin-6-mediated signaling pathway (GO:0070102)	2.94935520
76	pyrimidine nucleoside biosynthetic process (GO:0046134)	2.86946288
77	negative regulation of interleukin-8 production (GO:0032717)	2.79662689
78	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.79606936
79	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.79526059
80	ribosomal small subunit assembly (GO:0000028)	2.77006670
81	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.76284787
82	regulation of NIK/NF-kappaB signaling (GO:1901222)	2.75642386
83	L-methionine salvage (GO:0071267)	2.75467608
84	L-methionine biosynthetic process (GO:0071265)	2.75467608
85	amino acid salvage (GO:0043102)	2.75467608
86	T cell selection (GO:0045058)	2.68443095
87	positive regulation of prostaglandin secretion (GO:0032308)	2.68418972
88	negative regulation of keratinocyte proliferation (GO:0010839)	2.67161857
89	antigen processing and presentation of endogenous antigen (GO:0019883)	2.66637942
90	positive T cell selection (GO:0043368)	2.66070604
91	response to interferon-gamma (GO:0034341)	2.64079868
92	regulation of T-helper 1 cell differentiation (GO:0045625)	2.63993577
93	response to nitric oxide (GO:0071731)	2.63581115
94	positive regulation of neutrophil chemotaxis (GO:0090023)	2.62281774
95	positive regulation of neutrophil migration (GO:1902624)	2.62281774
96	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.61904920
97	tyrosine phosphorylation of STAT protein (GO:0007260)	2.59943512
98	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.58298886
99	cytokine biosynthetic process (GO:0042089)	2.58208243
100	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.57804662

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.86482804
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	5.74525746
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.85870970
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	4.26153028
5	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.70471796
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.65746353
7	RUNX_20019798_ChIP-Seq_JUKART_Human	2.46648228
8	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.42211281
9	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.35864908
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.22115974
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01677104
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.01584929
13	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.00176556
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.98519398
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95113013
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92113368
17	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.89551577
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.86761207
19	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.82399986
20	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.82290166
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78600829
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74159741
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74139932
24	MYB_26560356_Chip-Seq_TH2_Human	1.73219394
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72798895
26	GATA3_26560356_Chip-Seq_TH2_Human	1.70026396
27	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.67796445
28	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.64134688
29	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.62744949
30	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.60887411
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52753165
32	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.49030904
33	STAT1_20625510_ChIP-Seq_HELA_Human	1.47563150
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.43886561
35	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.40703296
36	BCL6_27268052_Chip-Seq_Bcells_Human	1.39271239
37	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.38269558
38	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.36402955
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.35860961
40	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.34716679
41	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34688756
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.32924663
43	CIITA_25753668_ChIP-Seq_RAJI_Human	1.31788929
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31206040
45	UTX_26944678_Chip-Seq_JUKART_Human	1.28860956
46	SPI1_23547873_ChIP-Seq_NB4_Human	1.27922084
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.26845967
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26525548
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.25874712
50	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.25266079
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23401738
52	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.22956872
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22814145
54	BCOR_27268052_Chip-Seq_Bcells_Human	1.21995111
55	AR_20517297_ChIP-Seq_VCAP_Human	1.21548313
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20735678
57	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20277752
58	VDR_24763502_ChIP-Seq_THP-1_Human	1.19861324
59	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.19426784
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.18553601
61	GATA3_27048872_Chip-Seq_THYMUS_Human	1.17098728
62	MYB_26560356_Chip-Seq_TH1_Human	1.16097190
63	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.15458147
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.15414859
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14565778
66	MAF_26560356_Chip-Seq_TH1_Human	1.14510247
67	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.14022041
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11877863
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11330227
70	E2F1_20622854_ChIP-Seq_HELA_Human	1.10651968
71	P68_20966046_ChIP-Seq_HELA_Human	1.10513795
72	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10042596
73	ERA_21632823_ChIP-Seq_H3396_Human	1.07682575
74	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04620781
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.04336093
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03424901
77	P300_27268052_Chip-Seq_Bcells_Human	1.02824715
78	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.02465597
79	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02234906
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.99110091
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99058953
82	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.98335190
83	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.97831792
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97029767
85	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95737026
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94867912
87	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.93527069
88	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.93525984
89	RAC3_21632823_ChIP-Seq_H3396_Human	0.92156525
90	SOX2_21211035_ChIP-Seq_LN229_Human	0.90112769
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.89851359
92	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87728114
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87404822
94	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.87170116
95	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.87095760
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87062014
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.86602526
98	ZNF274_21170338_ChIP-Seq_K562_Hela	0.86278587
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.86271433
100	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85401210

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003724_increased_susceptibility_to	4.21050489
2	MP0001835_abnormal_antigen_presentation	3.67724058
3	MP0003646_muscle_fatigue	3.46500467
4	MP0005000_abnormal_immune_tolerance	2.99151042
5	MP0001873_stomach_inflammation	2.91379730
6	MP0008875_abnormal_xenobiotic_pharmacok	2.86760403
7	MP0003806_abnormal_nucleotide_metabolis	2.82486402
8	MP0005671_abnormal_response_to	2.77697459
9	MP0002163_abnormal_gland_morphology	2.71683421
10	MP0006082_CNS_inflammation	2.70694576
11	MP0002148_abnormal_hypersensitivity_rea	2.65215275
12	MP0005360_urolithiasis	2.40511847
13	MP0002138_abnormal_hepatobiliary_system	2.29711739
14	MP0001800_abnormal_humoral_immune	2.17377948
15	MP0005387_immune_system_phenotype	2.16344004
16	MP0001790_abnormal_immune_system	2.16344004
17	MP0004145_abnormal_muscle_electrophysio	2.14261487
18	MP0002723_abnormal_immune_serum	2.03454520
19	MP0001346_abnormal_lacrimal_gland	2.01422049
20	MP0002452_abnormal_antigen_presenting	2.01388952
21	MP0009785_altered_susceptibility_to	1.99360753
22	MP0005165_increased_susceptibility_to	1.94900398
23	MP0003436_decreased_susceptibility_to	1.87360689
24	MP0010155_abnormal_intestine_physiology	1.86881492
25	MP0002420_abnormal_adaptive_immunity	1.86782372
26	MP0001819_abnormal_immune_cell	1.83998061
27	MP0005167_abnormal_blood-brain_barrier	1.81011777
28	MP0005025_abnormal_response_to	1.79400470
29	MP0005075_abnormal_melanosome_morpholog	1.77925985
30	MP0000685_abnormal_immune_system	1.77098219
31	MP0002234_abnormal_pharynx_morphology	1.76719145
32	MP0005646_abnormal_pituitary_gland	1.76151635
33	MP0008872_abnormal_physiological_respon	1.62508272
34	MP0005464_abnormal_platelet_physiology	1.56647916
35	MP0000538_abnormal_urinary_bladder	1.53763632
36	MP0001845_abnormal_inflammatory_respons	1.52215871
37	MP0002419_abnormal_innate_immunity	1.47648213
38	MP0009764_decreased_sensitivity_to	1.46811200
39	MP0003763_abnormal_thymus_physiology	1.46086584
40	MP0002102_abnormal_ear_morphology	1.44080574
41	MP0001853_heart_inflammation	1.44026918
42	MP0003866_abnormal_defecation	1.43541484
43	MP0005379_endocrine/exocrine_gland_phen	1.39864273
44	MP0000716_abnormal_immune_system	1.39664112
45	MP0006292_abnormal_olfactory_placode	1.37978301
46	MP0004036_abnormal_muscle_relaxation	1.37005030
47	MP0009333_abnormal_splenocyte_physiolog	1.32332690
48	MP0002398_abnormal_bone_marrow	1.29626537
49	MP0000689_abnormal_spleen_morphology	1.28345164
50	MP0008775_abnormal_heart_ventricle	1.25663302
51	MP0003075_altered_response_to	1.21158645
52	MP0002933_joint_inflammation	1.20384767
53	MP0001533_abnormal_skeleton_physiology	1.19233577
54	MP0002876_abnormal_thyroid_physiology	1.18251657
55	MP0002429_abnormal_blood_cell	1.17534257
56	MP0002166_altered_tumor_susceptibility	1.17102735
57	MP0001756_abnormal_urination	1.16612206
58	MP0002837_dystrophic_cardiac_calcinosis	1.16584188
59	MP0001663_abnormal_digestive_system	1.16459850
60	MP0002277_abnormal_respiratory_mucosa	1.15875180
61	MP0008873_increased_physiological_sensi	1.15322420
62	MP0002722_abnormal_immune_system	1.13743355
63	MP0009278_abnormal_bone_marrow	1.11753959
64	MP0001348_abnormal_lacrimal_gland	1.08874158
65	MP0000372_irregular_coat_pigmentation	1.05638242
66	MP0001545_abnormal_hematopoietic_system	1.04891502
67	MP0005397_hematopoietic_system_phenotyp	1.04891502
68	MP0005310_abnormal_salivary_gland	1.02255350
69	MP0001664_abnormal_digestion	1.00811554
70	MP0000613_abnormal_salivary_gland	1.00102243
71	MP0004147_increased_porphyrin_level	0.98394495
72	MP0002006_tumorigenesis	0.98194843
73	MP0008469_abnormal_protein_level	0.96802629
74	MP0005166_decreased_susceptibility_to	0.90192362
75	MP0000681_abnormal_thyroid_gland	0.90032033
76	MP0002405_respiratory_system_inflammati	0.88605106
77	MP0000383_abnormal_hair_follicle	0.86282289
78	MP0004782_abnormal_surfactant_physiolog	0.85736394
79	MP0009763_increased_sensitivity_to	0.84831056
80	MP0005451_abnormal_body_composition	0.83365075
81	MP0000858_altered_metastatic_potential	0.81227926
82	MP0009643_abnormal_urine_homeostasis	0.80955698
83	MP0001968_abnormal_touch/_nociception	0.80309002
84	MP0003191_abnormal_cellular_cholesterol	0.79634360
85	MP0002693_abnormal_pancreas_physiology	0.77617159
86	MP0000703_abnormal_thymus_morphology	0.75228615
87	MP0003279_aneurysm	0.74907411
88	MP0000343_altered_response_to	0.74747475
89	MP0004885_abnormal_endolymph	0.73164955
90	MP0000230_abnormal_systemic_arterial	0.72192076
91	MP0000467_abnormal_esophagus_morphology	0.71798987
92	MP0001905_abnormal_dopamine_level	0.71381635
93	MP0005332_abnormal_amino_acid	0.70683496
94	MP0004947_skin_inflammation	0.70505877
95	MP0002139_abnormal_hepatobiliary_system	0.68855294
96	MP0005381_digestive/alimentary_phenotyp	0.68582485
97	MP0006036_abnormal_mitochondrial_physio	0.65278632
98	MP0002736_abnormal_nociception_after	0.64041827
99	MP0003638_abnormal_response/metabolism_	0.63472659
100	MP0002932_abnormal_joint_morphology	0.63248485

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the pons (HP:0012110)	4.60523989
2	Difficulty running (HP:0009046)	4.42133921
3	Elevated erythrocyte sedimentation rate (HP:0003565)	4.18301146
4	Abnormality of the pons (HP:0007361)	4.15817667
5	Opisthotonus (HP:0002179)	4.13209095
6	Achilles tendon contracture (HP:0001771)	3.69967695
7	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.48006378
8	Abnormality of the periventricular white matter (HP:0002518)	3.41143606
9	Increased hepatocellular lipid droplets (HP:0006565)	3.38895148
10	Hip dysplasia (HP:0001385)	3.38609662
11	Abnormality of the prostate (HP:0008775)	3.33788208
12	Abnormality of the Achilles tendon (HP:0005109)	3.31685819
13	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.16196909
14	Increased intramyocellular lipid droplets (HP:0012240)	3.14279933
15	Panhypogammaglobulinemia (HP:0003139)	3.12561492
16	Congenital, generalized hypertrichosis (HP:0004540)	3.05853044
17	Decreased central vision (HP:0007663)	3.03809683
18	Lipid accumulation in hepatocytes (HP:0006561)	2.96045736
19	Exertional dyspnea (HP:0002875)	2.95088340
20	Hip contracture (HP:0003273)	2.88370037
21	Degeneration of anterior horn cells (HP:0002398)	2.76213505
22	Abnormality of the anterior horn cell (HP:0006802)	2.76213505
23	Mediastinal lymphadenopathy (HP:0100721)	2.76045075
24	Autoimmune thrombocytopenia (HP:0001973)	2.74709197
25	Progressive microcephaly (HP:0000253)	2.73729171
26	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.64433405
27	Increased muscle lipid content (HP:0009058)	2.63648995
28	Mitochondrial inheritance (HP:0001427)	2.61282559
29	Pustule (HP:0200039)	2.48012085
30	Microvesicular hepatic steatosis (HP:0001414)	2.45364237
31	Visual hallucinations (HP:0002367)	2.44385398
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.40275306
33	Abnormal number of erythroid precursors (HP:0012131)	2.38477710
34	Renal Fanconi syndrome (HP:0001994)	2.36307371
35	Agammaglobulinemia (HP:0004432)	2.36110999
36	3-Methylglutaconic aciduria (HP:0003535)	2.35516191
37	Meningitis (HP:0001287)	2.32121682
38	Abnormality of T cell physiology (HP:0011840)	2.24438696
39	Ulnar deviation of the wrist (HP:0003049)	2.20626571
40	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.20308176
41	Abnormality of B cell number (HP:0010975)	2.18606173
42	Eosinophilia (HP:0001880)	2.17695455
43	IgG deficiency (HP:0004315)	2.15181021
44	Hypoplasia of the uterus (HP:0000013)	2.15167231
45	Limited hip movement (HP:0008800)	2.14173213
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.13901571
47	Carpal bone hypoplasia (HP:0001498)	2.13227957
48	Pulmonary infiltrates (HP:0002113)	2.12059712
49	Impaired smooth pursuit (HP:0007772)	2.11907546
50	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.10692073
51	Vasculitis (HP:0002633)	2.09550516
52	Increased corneal curvature (HP:0100692)	2.08922650
53	Keratoconus (HP:0000563)	2.08922650
54	Increased CSF lactate (HP:0002490)	2.08569533
55	Pancreatic cysts (HP:0001737)	2.08265178
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05648007
57	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.05467597
58	Prostate neoplasm (HP:0100787)	2.03365820
59	Fasciculations (HP:0002380)	2.03175166
60	Hepatocellular necrosis (HP:0001404)	2.02217869
61	Acute necrotizing encephalopathy (HP:0006965)	2.01514151
62	Pancreatic fibrosis (HP:0100732)	2.01056539
63	Abnormality of T cells (HP:0002843)	2.00303508
64	Pulmonary fibrosis (HP:0002206)	1.99482352
65	Myositis (HP:0100614)	1.96951827
66	Hyperglycinemia (HP:0002154)	1.96500511
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.96116119
68	Esophageal neoplasm (HP:0100751)	1.95597482
69	Neoplasm of head and neck (HP:0012288)	1.95597482
70	Increased serum ferritin (HP:0003281)	1.92474562
71	Spondylolisthesis (HP:0003302)	1.92324767
72	Hypoproteinemia (HP:0003075)	1.91460592
73	Granulocytopenia (HP:0001913)	1.90546412
74	Chest pain (HP:0100749)	1.89311674
75	Short femoral neck (HP:0100864)	1.89200766
76	Delayed epiphyseal ossification (HP:0002663)	1.86677676
77	Prolonged neonatal jaundice (HP:0006579)	1.86238570
78	Abnormality of cells of the erythroid lineage (HP:0012130)	1.86119760
79	IgM deficiency (HP:0002850)	1.84776392
80	Restlessness (HP:0000711)	1.83838270
81	Poor eye contact (HP:0000817)	1.83664283
82	Periorbital edema (HP:0100539)	1.80833884
83	Facial edema (HP:0000282)	1.80483685
84	Asplenia (HP:0001746)	1.80475967
85	Bile duct proliferation (HP:0001408)	1.79918031
86	Abnormal biliary tract physiology (HP:0012439)	1.79918031
87	Parakeratosis (HP:0001036)	1.79848406
88	Stomach cancer (HP:0012126)	1.79500966
89	Hepatic necrosis (HP:0002605)	1.78737920
90	Dyskinesia (HP:0100660)	1.78491849
91	Small epiphyses (HP:0010585)	1.76739987
92	Autoimmune hemolytic anemia (HP:0001890)	1.75778635
93	Increased serum lactate (HP:0002151)	1.75730478
94	Molar tooth sign on MRI (HP:0002419)	1.74724300
95	Abnormality of midbrain morphology (HP:0002418)	1.74724300
96	Abnormality of male internal genitalia (HP:0000022)	1.74562297
97	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.74398908
98	Lactic acidosis (HP:0003128)	1.73139944
99	Absent phalangeal crease (HP:0006109)	1.72126186
100	Abnormality of the pleura (HP:0002103)	1.71118493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	4.71731944
2	MAP4K1	4.16895957
3	TAOK3	3.43834490
4	TLK1	3.11586347
5	TIE1	3.10778948
6	TXK	3.04248744
7	KDR	2.87094502
8	TESK1	2.62640012
9	ZAK	2.50460228
10	VRK2	2.45561115
11	BCKDK	2.25544657
12	KIT	2.23674502
13	CSF1R	2.19872018
14	IKBKE	1.93400778
15	JAK3	1.81092207
16	NME2	1.79501945
17	ADRBK2	1.77167159
18	PHKG2	1.71690402
19	PHKG1	1.71690402
20	MAPKAPK3	1.68100584
21	TBK1	1.65705983
22	TEC	1.56690693
23	SYK	1.55881804
24	GRK1	1.52999471
25	IKBKB	1.51478863
26	ITK	1.41739142
27	TESK2	1.32473666
28	VRK1	1.29168730
29	RPS6KA5	1.28806744
30	CSNK1G1	1.28271625
31	LYN	1.23042266
32	MST4	1.21695533
33	MUSK	1.21264813
34	BMPR1B	1.10791933
35	CCNB1	1.08134193
36	GRK7	1.06797751
37	LCK	1.04906484
38	PIK3CG	1.02693858
39	MYLK	0.96113547
40	ARAF	0.94647354
41	CDK8	0.94392132
42	MAP3K14	0.89157135
43	PKN1	0.87690767
44	OBSCN	0.86500764
45	BLK	0.86230676
46	DAPK1	0.85862140
47	PRKCQ	0.83711216
48	PIM2	0.82188775
49	FES	0.81581246
50	NLK	0.81070582
51	GRK6	0.79418279
52	FRK	0.76552835
53	MAPKAPK5	0.76026542
54	BTK	0.75821653
55	RIPK4	0.72343076
56	CSNK1G3	0.72040252
57	MATK	0.70443311
58	INSRR	0.70174853
59	MAP2K6	0.70102271
60	TRPM7	0.69383580
61	ADRBK1	0.65486128
62	PLK2	0.63067473
63	PDK1	0.62765215
64	CSK	0.60210814
65	ABL1	0.59134391
66	PAK1	0.58863724
67	FLT3	0.54340226
68	GRK5	0.54254946
69	IGF1R	0.53267905
70	DYRK1A	0.48627855
71	EPHA2	0.47746959
72	PRKCA	0.46815530
73	CSNK2A1	0.45937869
74	DAPK3	0.45257901
75	ILK	0.44018995
76	OXSR1	0.43892343
77	MAP2K7	0.42887353
78	MAP4K2	0.41887287
79	CDK4	0.41492322
80	PRKCI	0.41234943
81	CSNK1A1	0.40802551
82	IRAK3	0.40634854
83	IRAK4	0.39829870
84	CSNK1A1L	0.38729716
85	CSNK2A2	0.37000475
86	LMTK2	0.36521867
87	CSNK1G2	0.36051068
88	MAPKAPK2	0.35884835
89	HCK	0.34970729
90	CDC42BPA	0.34274462
91	DAPK2	0.33248187
92	FYN	0.32497619
93	EGFR	0.32344800
94	MAPK3	0.31642245
95	MOS	0.31612357
96	NUAK1	0.28587177
97	CAMKK1	0.25960453
98	AURKA	0.25492318
99	TGFBR2	0.25326646
100	TGFBR1	0.24195617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.95462387
2	Allograft rejection_Homo sapiens_hsa05330	4.75918592
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.52311595
4	Graft-versus-host disease_Homo sapiens_hsa05332	4.47630779
5	Sulfur relay system_Homo sapiens_hsa04122	3.93830709
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.86007672
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.82034846
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.77684565
9	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.52608606
10	Viral myocarditis_Homo sapiens_hsa05416	2.45458133
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.34565503
12	Ribosome_Homo sapiens_hsa03010	2.32381440
13	Leishmaniasis_Homo sapiens_hsa05140	2.25788974
14	Primary immunodeficiency_Homo sapiens_hsa05340	2.09415392
15	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.98461788
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.92098202
17	Pentose phosphate pathway_Homo sapiens_hsa00030	1.91099740
18	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.82706236
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.65587638
20	Proteasome_Homo sapiens_hsa03050	1.64876933
21	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.30650616
22	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.25750882
23	Influenza A_Homo sapiens_hsa05164	1.25561615
24	DNA replication_Homo sapiens_hsa03030	1.09808595
25	Phototransduction_Homo sapiens_hsa04744	1.09220276
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08891137
27	Measles_Homo sapiens_hsa05162	1.02395197
28	Herpes simplex infection_Homo sapiens_hsa05168	0.97356996
29	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94987868
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93840646
31	Oxidative phosphorylation_Homo sapiens_hsa00190	0.93838610
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.93337695
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92438389
34	Fat digestion and absorption_Homo sapiens_hsa04975	0.90193785
35	Tuberculosis_Homo sapiens_hsa05152	0.88223007
36	Sulfur metabolism_Homo sapiens_hsa00920	0.82892431
37	Toxoplasmosis_Homo sapiens_hsa05145	0.81310488
38	Parkinsons disease_Homo sapiens_hsa05012	0.78917003
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71159111
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69809089
41	Legionellosis_Homo sapiens_hsa05134	0.67333010
42	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67221081
43	Alzheimers disease_Homo sapiens_hsa05010	0.65539858
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.65188397
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.64053206
46	Homologous recombination_Homo sapiens_hsa03440	0.62774328
47	Purine metabolism_Homo sapiens_hsa00230	0.61628499
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58950810
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.57673716
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57306656
51	Base excision repair_Homo sapiens_hsa03410	0.54610479
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53738021
53	One carbon pool by folate_Homo sapiens_hsa00670	0.50912212
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50381126
55	Olfactory transduction_Homo sapiens_hsa04740	0.50031258
56	Salivary secretion_Homo sapiens_hsa04970	0.48051191
57	Phagosome_Homo sapiens_hsa04145	0.46235314
58	Mismatch repair_Homo sapiens_hsa03430	0.45611757
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43263445
60	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.42565230
61	Caffeine metabolism_Homo sapiens_hsa00232	0.41737238
62	Apoptosis_Homo sapiens_hsa04210	0.40188575
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39418427
64	Carbon metabolism_Homo sapiens_hsa01200	0.37719884
65	Other glycan degradation_Homo sapiens_hsa00511	0.36530826
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36170943
67	Malaria_Homo sapiens_hsa05144	0.33475384
68	Fatty acid elongation_Homo sapiens_hsa00062	0.31559076
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.31445821
70	Peroxisome_Homo sapiens_hsa04146	0.31345689
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31147645
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30985396
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30079372
74	Osteoclast differentiation_Homo sapiens_hsa04380	0.28147968
75	Huntingtons disease_Homo sapiens_hsa05016	0.28052994
76	African trypanosomiasis_Homo sapiens_hsa05143	0.26953868
77	Propanoate metabolism_Homo sapiens_hsa00640	0.26230374
78	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.26063805
79	Butanoate metabolism_Homo sapiens_hsa00650	0.25973862
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.24770449
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24500830
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24399987
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24347290
84	Pertussis_Homo sapiens_hsa05133	0.23899081
85	RNA degradation_Homo sapiens_hsa03018	0.23665889
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.22135224
87	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.20161323
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.18300218
89	Metabolic pathways_Homo sapiens_hsa01100	0.17888448
90	HTLV-I infection_Homo sapiens_hsa05166	0.17513911
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.17375111
92	Lysosome_Homo sapiens_hsa04142	0.16577532
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.14866706
94	RNA polymerase_Homo sapiens_hsa03020	0.13989303
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.13688273
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.13092463
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.12551953
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.12085320
99	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.11785195
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.10763106

HLA-DRB8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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