HLA-E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.26132794
2* negative regulation of cell killing (GO:0031342)6.21404307
3* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.21404307
4positive regulation of gamma-delta T cell activation (GO:0046645)6.01933160
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.68873349
6* antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.68873349
7* antigen processing and presentation of endogenous antigen (GO:0019883)5.55329167
8regulation of B cell receptor signaling pathway (GO:0050855)4.95950471
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89922019
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.89922019
11modulation by symbiont of host immune response (GO:0052553)4.89922019
12positive regulation by symbiont of host defense response (GO:0052509)4.89922019
13modulation by symbiont of host defense response (GO:0052031)4.89922019
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89922019
15detection of other organism (GO:0098543)4.70791475
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64165915
17neutrophil activation involved in immune response (GO:0002283)4.62341297
18detection of bacterium (GO:0016045)4.61679579
19regulation of gamma-delta T cell activation (GO:0046643)4.51084388
20macrophage activation involved in immune response (GO:0002281)4.33985023
21regulation of gamma-delta T cell differentiation (GO:0045586)4.23892426
22response to interleukin-15 (GO:0070672)4.21534805
23leukocyte aggregation (GO:0070486)4.20205531
24immunoglobulin mediated immune response (GO:0016064)3.99922730
25cellular response to interleukin-15 (GO:0071350)3.97310499
26negative thymic T cell selection (GO:0045060)3.92120187
27negative T cell selection (GO:0043383)3.90937743
28negative regulation of interleukin-12 production (GO:0032695)3.89951380
29* negative regulation of lymphocyte mediated immunity (GO:0002707)3.89469166
30detection of external biotic stimulus (GO:0098581)3.88458878
31response to peptidoglycan (GO:0032494)3.81891483
32cellular extravasation (GO:0045123)3.74991915
33neutrophil activation (GO:0042119)3.71447507
34positive thymic T cell selection (GO:0045059)3.71114271
35negative regulation of T cell mediated immunity (GO:0002710)3.68586565
36* type I interferon signaling pathway (GO:0060337)3.66640416
37* cellular response to type I interferon (GO:0071357)3.66640416
38* response to type I interferon (GO:0034340)3.64839624
39regulation of T cell tolerance induction (GO:0002664)3.64633424
40regulation of interferon-beta biosynthetic process (GO:0045357)3.60540822
41* negative regulation of leukocyte mediated immunity (GO:0002704)3.55617067
42microglial cell activation (GO:0001774)3.53314991
43B cell receptor signaling pathway (GO:0050853)3.51170267
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.46235818
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43567576
46response to host immune response (GO:0052572)3.43567576
47granulocyte activation (GO:0036230)3.43545499
48myeloid cell activation involved in immune response (GO:0002275)3.43537101
49regulation of tolerance induction (GO:0002643)3.42710477
50respiratory burst (GO:0045730)3.40954203
51detection of molecule of bacterial origin (GO:0032490)3.40394663
52detection of biotic stimulus (GO:0009595)3.39651441
53regulation of B cell differentiation (GO:0045577)3.34793386
54tolerance induction (GO:0002507)3.32727725
55positive regulation of B cell differentiation (GO:0045579)3.32715535
56regulation of regulatory T cell differentiation (GO:0045589)3.31716630
57T cell migration (GO:0072678)3.30723438
58regulation of mast cell degranulation (GO:0043304)3.29526587
59* interferon-gamma-mediated signaling pathway (GO:0060333)3.28466533
60positive T cell selection (GO:0043368)3.27926386
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26759522
62regulation of alpha-beta T cell proliferation (GO:0046640)3.26116221
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25897779
64leukocyte migration involved in inflammatory response (GO:0002523)3.24672279
65T cell selection (GO:0045058)3.24102182
66* regulation of T cell mediated cytotoxicity (GO:0001914)3.21381663
67B cell mediated immunity (GO:0019724)3.18894627
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18857545
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18605628
70response to host (GO:0075136)3.18605628
71response to host defenses (GO:0052200)3.18605628
72thymic T cell selection (GO:0045061)3.18260952
73defense response to protozoan (GO:0042832)3.16082705
74macrophage activation (GO:0042116)3.15419712
75positive regulation of mast cell activation (GO:0033005)3.09598079
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08545267
77* positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08350557
78response to muramyl dipeptide (GO:0032495)3.07939983
79* regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05465248
80* regulation of natural killer cell mediated immunity (GO:0002715)3.05465248
81negative regulation of erythrocyte differentiation (GO:0045647)3.02028543
82negative regulation of T-helper cell differentiation (GO:0045623)3.01824066
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01824066
84germinal center formation (GO:0002467)3.01141547
85regulation of antigen processing and presentation (GO:0002577)3.00944229
86regulation of mast cell activation involved in immune response (GO:0033006)3.00779490
87regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00479630
88leukocyte degranulation (GO:0043299)2.98542507
89positive regulation of tolerance induction (GO:0002645)2.98004286
90activated T cell proliferation (GO:0050798)2.96876932
91negative regulation of phagocytosis (GO:0050765)2.96148848
92dendritic cell chemotaxis (GO:0002407)2.95548612
93regulation of mast cell activation (GO:0033003)2.92831640
94positive regulation of antigen processing and presentation (GO:0002579)2.88753620
95production of molecular mediator involved in inflammatory response (GO:0002532)2.88505077
96neutrophil mediated immunity (GO:0002446)2.87466836
97regulation of leukocyte degranulation (GO:0043300)2.87413744
98negative regulation of alpha-beta T cell activation (GO:0046636)2.85363828
99dendritic cell migration (GO:0036336)2.84153370
100* regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84040049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.88851331
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.52578769
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.30086381
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03582970
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.91756422
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.55529522
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49815808
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01610699
9RUNX_20019798_ChIP-Seq_JUKART_Human2.94599053
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.91800467
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88415901
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68024983
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61216051
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.57918333
15MYB_26560356_Chip-Seq_TH2_Human2.48015522
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45636394
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45004078
18MAF_26560356_Chip-Seq_TH1_Human2.40905961
19SPI1_23547873_ChIP-Seq_NB4_Human2.38395515
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38074436
21VDR_21846776_ChIP-Seq_THP-1_Human2.36596147
22VDR_24763502_ChIP-Seq_THP-1_Human2.35206366
23SPI1_23127762_ChIP-Seq_K562_Human2.32678258
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30908570
25SCL_19346495_ChIP-Seq_HPC-7_Human2.29746707
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24274889
27UTX_26944678_Chip-Seq_JUKART_Human2.15086757
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.13404910
29MYB_26560356_Chip-Seq_TH1_Human2.09369879
30MYC_22102868_ChIP-Seq_BL_Human2.06393058
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03094345
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99591816
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95602217
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94851476
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83844923
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82169161
37TCF7_22412390_ChIP-Seq_EML_Mouse1.80915324
38GATA3_27048872_Chip-Seq_THYMUS_Human1.77223921
39MAF_26560356_Chip-Seq_TH2_Human1.76889858
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.73087409
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72817305
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70329132
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68607220
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.58932955
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58363888
46KDM2B_26808549_Chip-Seq_DND41_Human1.55330309
47VDR_24787735_ChIP-Seq_THP-1_Human1.55285889
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.53490947
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51887840
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45394421
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43811501
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41333276
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40327928
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39326783
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.38656564
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37002360
57GATA3_26560356_Chip-Seq_TH2_Human1.35923795
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34771665
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33100910
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30787542
61GATA1_19941826_ChIP-Seq_K562_Human1.29454413
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.27717917
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26655296
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25618393
65LXR_22292898_ChIP-Seq_THP-1_Human1.25314338
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23451007
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22941777
68PU_27001747_Chip-Seq_BMDM_Mouse1.22105113
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21690486
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21272584
71GATA1_22025678_ChIP-Seq_K562_Human1.19565788
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18470286
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18032508
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17430578
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15627419
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14163299
77BCL6_27268052_Chip-Seq_Bcells_Human1.14013057
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13101370
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12843497
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12685231
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11030364
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09261450
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06607346
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04748911
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04524648
86BCOR_27268052_Chip-Seq_Bcells_Human1.03777519
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00660308
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96855492
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94836728
90* GATA2_19941826_ChIP-Seq_K562_Human0.94546949
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92949599
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92149550
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90309448
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89852972
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87431588
96NCOR1_26117541_ChIP-Seq_K562_Human0.85032802
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.83052626
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82567989
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81235472
100SPI1_20517297_ChIP-Seq_HL60_Human0.80314780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.66947541
2MP0003436_decreased_susceptibility_to3.99655676
3MP0001835_abnormal_antigen_presentation3.86138278
4MP0005671_abnormal_response_to3.50347162
5MP0003303_peritoneal_inflammation3.45905122
6MP0001800_abnormal_humoral_immune3.03595210
7MP0005000_abnormal_immune_tolerance3.00159159
8MP0006082_CNS_inflammation2.99135505
9MP0005387_immune_system_phenotype2.93409427
10MP0001790_abnormal_immune_system2.93409427
11MP0000685_abnormal_immune_system2.92950612
12MP0002419_abnormal_innate_immunity2.92087425
13MP0009785_altered_susceptibility_to2.90667580
14MP0005025_abnormal_response_to2.88383007
15MP0003763_abnormal_thymus_physiology2.78601099
16MP0002723_abnormal_immune_serum2.67760964
17MP0002452_abnormal_antigen_presenting2.57990204
18MP0002420_abnormal_adaptive_immunity2.57767930
19MP0001819_abnormal_immune_cell2.55090547
20MP0003300_gastrointestinal_ulcer2.50988902
21MP0002148_abnormal_hypersensitivity_rea2.40522868
22MP0005464_abnormal_platelet_physiology2.29672342
23MP0002405_respiratory_system_inflammati2.10440156
24MP0001533_abnormal_skeleton_physiology2.09308299
25MP0010155_abnormal_intestine_physiology2.08568058
26MP0003191_abnormal_cellular_cholesterol2.01376202
27MP0002398_abnormal_bone_marrow1.98700161
28MP0000716_abnormal_immune_system1.94889873
29MP0009333_abnormal_splenocyte_physiolog1.94508870
30MP0004947_skin_inflammation1.85132129
31MP0000465_gastrointestinal_hemorrhage1.82975551
32MP0001845_abnormal_inflammatory_respons1.81797880
33MP0003866_abnormal_defecation1.75965288
34MP0000689_abnormal_spleen_morphology1.64612779
35MP0002132_abnormal_respiratory_system1.63672438
36MP0002722_abnormal_immune_system1.60783005
37MP0008260_abnormal_autophagy1.58154858
38MP0002429_abnormal_blood_cell1.53957575
39MP0003828_pulmonary_edema1.53887533
40MP0003172_abnormal_lysosome_physiology1.52032777
41MP0000703_abnormal_thymus_morphology1.50305004
42MP0005310_abnormal_salivary_gland1.47755510
43MP0008469_abnormal_protein_level1.46481388
44MP0000858_altered_metastatic_potential1.41277900
45MP0009764_decreased_sensitivity_to1.40221315
46MP0009278_abnormal_bone_marrow1.39283698
47MP0001873_stomach_inflammation1.39211680
48MP0001851_eye_inflammation1.38696734
49MP0004381_abnormal_hair_follicle1.35175249
50MP0003183_abnormal_peptide_metabolism1.33636879
51MP0002998_abnormal_bone_remodeling1.29085817
52MP0002166_altered_tumor_susceptibility1.28428746
53MP0004883_abnormal_blood_vessel1.27116319
54MP0004510_myositis1.26069001
55MP0003075_altered_response_to1.22478342
56MP0002396_abnormal_hematopoietic_system1.22260425
57MP0005058_abnormal_lysosome_morphology1.17943321
58MP0005451_abnormal_body_composition1.17517017
59MP0002277_abnormal_respiratory_mucosa1.15457581
60MP0003690_abnormal_glial_cell1.15380522
61MP0005166_decreased_susceptibility_to1.10474216
62MP0001545_abnormal_hematopoietic_system1.09446486
63MP0005397_hematopoietic_system_phenotyp1.09446486
64MP0005164_abnormal_response_to1.04165229
65MP0002138_abnormal_hepatobiliary_system1.03554157
66MP0008004_abnormal_stomach_pH1.03516743
67MP0002933_joint_inflammation1.01747467
68MP0003448_altered_tumor_morphology1.00073889
69MP0001853_heart_inflammation0.96829518
70MP0001663_abnormal_digestive_system0.96796351
71MP0000343_altered_response_to0.96350035
72MP0009763_increased_sensitivity_to0.93993293
73MP0000604_amyloidosis0.88189597
74MP0005390_skeleton_phenotype0.86331491
75MP0003045_fibrosis0.83850346
76MP0005075_abnormal_melanosome_morpholog0.82534055
77MP0000249_abnormal_blood_vessel0.82132792
78MP0002006_tumorigenesis0.81182309
79MP0009840_abnormal_foam_cell0.76322528
80MP0000490_abnormal_crypts_of0.72689318
81MP0002254_reproductive_system_inflammat0.72026771
82MP0004808_abnormal_hematopoietic_stem0.68405485
83MP0009765_abnormal_xenobiotic_induced0.67452980
84MP0003795_abnormal_bone_structure0.66504490
85MP0003091_abnormal_cell_migration0.65347022
86MP0008874_decreased_physiological_sensi0.65250835
87MP0004130_abnormal_muscle_cell0.64033422
88MP0003806_abnormal_nucleotide_metabolis0.61691168
89MP0000015_abnormal_ear_pigmentation0.59736168
90MP0005167_abnormal_blood-brain_barrier0.56864438
91MP0001958_emphysema0.55781617
92MP0001986_abnormal_taste_sensitivity0.55611235
93MP0003656_abnormal_erythrocyte_physiolo0.55523796
94MP0005381_digestive/alimentary_phenotyp0.54747264
95MP0002693_abnormal_pancreas_physiology0.49673755
96MP0002019_abnormal_tumor_incidence0.49169283
97MP0002332_abnormal_exercise_endurance0.48329150
98MP0000609_abnormal_liver_physiology0.46643125
99MP0000920_abnormal_myelination0.46486877
100MP0001348_abnormal_lacrimal_gland0.46109980

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.35378998
2Myositis (HP:0100614)5.57340447
3Recurrent abscess formation (HP:0002722)5.38475409
4Recurrent bacterial skin infections (HP:0005406)5.31772530
5Orchitis (HP:0100796)5.15921103
6Abnormality of macrophages (HP:0004311)5.02360602
7Optic neuritis (HP:0100653)4.93702764
8Retrobulbar optic neuritis (HP:0100654)4.93702764
9Stomatitis (HP:0010280)4.77670787
10Elevated erythrocyte sedimentation rate (HP:0003565)4.75311492
11Recurrent gram-negative bacterial infections (HP:0005420)4.30824512
12Recurrent fungal infections (HP:0002841)4.19134388
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.08329656
14Mediastinal lymphadenopathy (HP:0100721)4.00792449
15Gastrointestinal infarctions (HP:0005244)4.00468781
16Meningitis (HP:0001287)4.00123591
17Chronic obstructive pulmonary disease (HP:0006510)3.81171143
18Obstructive lung disease (HP:0006536)3.81171143
19T lymphocytopenia (HP:0005403)3.77579975
20Spontaneous hematomas (HP:0007420)3.71122482
21Encephalitis (HP:0002383)3.70656790
22Abnormality of T cell number (HP:0011839)3.69565058
23Recurrent skin infections (HP:0001581)3.68797323
24Vasculitis (HP:0002633)3.64243755
25Keratoconjunctivitis sicca (HP:0001097)3.63976028
26Prolonged bleeding time (HP:0003010)3.59531812
27Increased IgE level (HP:0003212)3.58173604
28Chronic mucocutaneous candidiasis (HP:0002728)3.54562688
29Recurrent cutaneous fungal infections (HP:0011370)3.54562688
30Keratoconjunctivitis (HP:0001096)3.53376498
31Pulmonary infiltrates (HP:0002113)3.23133749
32Gingivitis (HP:0000230)3.22864275
33Chest pain (HP:0100749)3.17321569
34Urticaria (HP:0001025)3.12718617
35Abnormality of T cells (HP:0002843)3.11975582
36Pustule (HP:0200039)3.10450017
37Cellulitis (HP:0100658)3.05231849
38Hemoptysis (HP:0002105)3.04714963
39Epistaxis (HP:0000421)3.02810296
40Recurrent viral infections (HP:0004429)3.02359688
41Gingival bleeding (HP:0000225)3.02173978
42Increased IgM level (HP:0003496)3.00892653
43Leukocytosis (HP:0001974)2.94619384
44Inflammation of the large intestine (HP:0002037)2.94049024
45Panhypogammaglobulinemia (HP:0003139)2.91912370
46Gastrointestinal inflammation (HP:0004386)2.83834707
47Petechiae (HP:0000967)2.83173519
48Arterial thrombosis (HP:0004420)2.82256518
49Granulocytopenia (HP:0001913)2.73690886
50Pulmonary embolism (HP:0002204)2.69423423
51Recurrent bronchitis (HP:0002837)2.61786462
52Purpura (HP:0000979)2.61768057
53Agammaglobulinemia (HP:0004432)2.61733538
54Episodic fever (HP:0001954)2.58090482
55Lymphopenia (HP:0001888)2.57155872
56Hypochromic anemia (HP:0001931)2.56800897
57Abnormality of T cell physiology (HP:0011840)2.56095080
58Anorexia (HP:0002039)2.54796421
59Hypergammaglobulinemia (HP:0010702)2.53884972
60Colitis (HP:0002583)2.53143134
61Autoimmune hemolytic anemia (HP:0001890)2.49197221
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.46785146
63Eosinophilia (HP:0001880)2.44417733
64Gangrene (HP:0100758)2.41448283
65Abnormality of the pleura (HP:0002103)2.37750382
66Osteomyelitis (HP:0002754)2.36142922
67Hypochromic microcytic anemia (HP:0004840)2.33976979
68Chronic otitis media (HP:0000389)2.28216239
69Autoimmune thrombocytopenia (HP:0001973)2.27285215
70Nasal polyposis (HP:0100582)2.25419200
71Gastrointestinal stroma tumor (HP:0100723)2.23868715
72Sepsis (HP:0100806)2.23803622
73Peritonitis (HP:0002586)2.23453833
74IgM deficiency (HP:0002850)2.23071549
75Amyloidosis (HP:0011034)2.22407526
76Abnormality of eosinophils (HP:0001879)2.20209345
77Joint swelling (HP:0001386)2.14677242
78Glomerulopathy (HP:0100820)2.14592865
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14016180
80Abnormal platelet volume (HP:0011876)2.13586453
81Abnormality of the nasal mucosa (HP:0000433)2.11693159
82Chronic diarrhea (HP:0002028)2.10021157
83Abnormality of liposaccharide metabolism (HP:0010968)2.08498302
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.08498302
85Abnormality of glycolipid metabolism (HP:0010969)2.08498302
86IgG deficiency (HP:0004315)2.06507199
87Skin ulcer (HP:0200042)2.05791223
88Abnormality of the peritoneum (HP:0002585)2.04137862
89Systemic lupus erythematosus (HP:0002725)2.04093301
90Vertigo (HP:0002321)2.03752832
91Interstitial pulmonary disease (HP:0006530)2.02806699
92Increased cerebral lipofuscin (HP:0011813)2.02757556
93Microcytic anemia (HP:0001935)2.00827882
94Hepatosplenomegaly (HP:0001433)2.00468951
95Loss of speech (HP:0002371)2.00078920
96Increased serum ferritin (HP:0003281)1.99608487
97Keratitis (HP:0000491)1.98922246
98Verrucae (HP:0200043)1.97346950
99Papilloma (HP:0012740)1.97346950
100Acne (HP:0001061)1.96833400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.31749493
2MAP4K14.05523667
3TYK22.82577993
4BLK2.78537865
5TXK2.65686167
6CSK2.64920074
7ERN12.63686139
8FES2.62529987
9IRAK42.60172863
10MAP2K32.33890993
11GRK62.26947433
12ZAP702.26547456
13PRPF4B2.19854877
14MAP3K142.06070316
15MAP3K132.03675990
16BTK2.02942938
17JAK32.01423812
18TNK21.99830861
19EPHB11.92704921
20TAOK31.87702621
21IKBKE1.86222271
22SYK1.83388017
23JAK11.72499652
24TBK11.70507080
25HCK1.68828849
26FGR1.62549500
27MAP3K31.60068079
28ITK1.57790750
29MAP3K111.49721735
30LYN1.41611446
31TAOK11.39101145
32LCK1.36314191
33CSF1R1.34359462
34JAK21.29929539
35SIK31.26117547
36KIT1.25801154
37IKBKB1.19254704
38TEC1.19087650
39MAP3K11.16460328
40TESK21.09870914
41FGFR41.01237635
42MARK31.00788872
43BMPR20.99405863
44TGFBR20.96820760
45STK100.95326283
46MATK0.93650678
47KSR20.86989386
48PDK10.86245242
49TAOK20.84976111
50IRAK10.84788605
51TRIB30.81381108
52MARK20.80655884
53EPHA30.77646518
54FGFR30.77595472
55SIK20.77078482
56PTK60.75649780
57PRKCQ0.74585922
58CDC42BPA0.74524746
59PRKD20.74088115
60YES10.73073508
61MAP3K70.71444327
62FYN0.70297933
63MAPK120.70011487
64PDPK10.68371057
65NLK0.66484652
66LRRK20.66266323
67CAMKK10.66199243
68MAPK70.66075683
69HIPK20.63116718
70GRK70.62122241
71PTK2B0.61627457
72PIK3CG0.56254995
73SMG10.55290125
74PIM10.55230517
75KDR0.54187966
76CAMKK20.53361334
77MAP3K60.52931680
78SIK10.52137983
79IRAK20.51053220
80MAP2K60.48391365
81DYRK1B0.44487775
82MAP3K50.44407385
83RIPK10.41944888
84RET0.39250211
85MAPKAPK20.38757613
86MAPK110.36988211
87MAP3K20.36616749
88RPS6KL10.35549262
89RPS6KC10.35549262
90MAP2K20.35265334
91STK380.34166237
92PASK0.33594917
93SGK30.33478500
94STK110.33180051
95BMX0.32744794
96RAF10.30000719
97CHUK0.29886872
98RPS6KA60.29842446
99CDK190.29481691
100PRKD10.28070671

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053322.88004543
2Leishmaniasis_Homo sapiens_hsa051402.86717358
3* Allograft rejection_Homo sapiens_hsa053302.81978722
4Primary immunodeficiency_Homo sapiens_hsa053402.80946259
5Staphylococcus aureus infection_Homo sapiens_hsa051502.77454983
6Osteoclast differentiation_Homo sapiens_hsa043802.72148014
7* Autoimmune thyroid disease_Homo sapiens_hsa053202.65177424
8* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36024532
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27901802
10B cell receptor signaling pathway_Homo sapiens_hsa046622.27543463
11* Type I diabetes mellitus_Homo sapiens_hsa049402.02441161
12* Antigen processing and presentation_Homo sapiens_hsa046121.97486825
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93565713
14Tuberculosis_Homo sapiens_hsa051521.93557447
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.93216415
16T cell receptor signaling pathway_Homo sapiens_hsa046601.89069972
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.87261096
18Hematopoietic cell lineage_Homo sapiens_hsa046401.85899685
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83131885
20Measles_Homo sapiens_hsa051621.81371179
21Malaria_Homo sapiens_hsa051441.76926104
22Asthma_Homo sapiens_hsa053101.76920977
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73111173
24* Viral myocarditis_Homo sapiens_hsa054161.68207563
25Chemokine signaling pathway_Homo sapiens_hsa040621.61907286
26Toxoplasmosis_Homo sapiens_hsa051451.57949120
27Acute myeloid leukemia_Homo sapiens_hsa052211.56711631
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53446420
29Influenza A_Homo sapiens_hsa051641.50468775
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50108742
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.42352042
32* Herpes simplex infection_Homo sapiens_hsa051681.40088934
33TNF signaling pathway_Homo sapiens_hsa046681.33782506
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29712852
35Legionellosis_Homo sapiens_hsa051341.27493780
36Rheumatoid arthritis_Homo sapiens_hsa053231.25603466
37Other glycan degradation_Homo sapiens_hsa005111.25278870
38Platelet activation_Homo sapiens_hsa046111.22800661
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.21822568
40* Phagosome_Homo sapiens_hsa041451.18962945
41Pertussis_Homo sapiens_hsa051331.13494700
42African trypanosomiasis_Homo sapiens_hsa051431.11622004
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10220485
44Hepatitis C_Homo sapiens_hsa051601.08326077
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06190602
46Hepatitis B_Homo sapiens_hsa051611.05552186
47Non-small cell lung cancer_Homo sapiens_hsa052231.00805909
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00145194
49Apoptosis_Homo sapiens_hsa042100.96324973
50* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95123400
51Shigellosis_Homo sapiens_hsa051310.93443257
52Salmonella infection_Homo sapiens_hsa051320.90020456
53Pancreatic cancer_Homo sapiens_hsa052120.86215529
54VEGF signaling pathway_Homo sapiens_hsa043700.83867505
55Lysosome_Homo sapiens_hsa041420.79381944
56Chronic myeloid leukemia_Homo sapiens_hsa052200.76643573
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75069771
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73050762
59Prolactin signaling pathway_Homo sapiens_hsa049170.71599819
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68608383
61* Endocytosis_Homo sapiens_hsa041440.67864743
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.66235811
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.65615906
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64414601
65* Epstein-Barr virus infection_Homo sapiens_hsa051690.63975846
66Renal cell carcinoma_Homo sapiens_hsa052110.60313316
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.59709415
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.59309842
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56905637
70* HTLV-I infection_Homo sapiens_hsa051660.55772373
71FoxO signaling pathway_Homo sapiens_hsa040680.55585867
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.55452856
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53873410
74* Viral carcinogenesis_Homo sapiens_hsa052030.53832177
75Notch signaling pathway_Homo sapiens_hsa043300.52818466
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52035031
77Amoebiasis_Homo sapiens_hsa051460.49963249
78Choline metabolism in cancer_Homo sapiens_hsa052310.49856158
79Dorso-ventral axis formation_Homo sapiens_hsa043200.46306951
80Insulin resistance_Homo sapiens_hsa049310.45897216
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45375314
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45174807
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44788425
84Endometrial cancer_Homo sapiens_hsa052130.43526839
85GnRH signaling pathway_Homo sapiens_hsa049120.43030079
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41735704
87MAPK signaling pathway_Homo sapiens_hsa040100.41168838
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39407739
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.38735503
90Inositol phosphate metabolism_Homo sapiens_hsa005620.37931403
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37889900
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37526402
93mTOR signaling pathway_Homo sapiens_hsa041500.34807242
94Rap1 signaling pathway_Homo sapiens_hsa040150.34337224
95Colorectal cancer_Homo sapiens_hsa052100.33273524
96Regulation of autophagy_Homo sapiens_hsa041400.31985986
97Arachidonic acid metabolism_Homo sapiens_hsa005900.29916709
98Type II diabetes mellitus_Homo sapiens_hsa049300.29131270
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28566695
100Complement and coagulation cascades_Homo sapiens_hsa046100.28360402

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