HLA-F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.69978208
2response to pheromone (GO:0019236)9.36216471
3sperm motility (GO:0030317)9.02787775
4chromosome condensation (GO:0030261)8.29191456
5DNA packaging (GO:0006323)7.82648239
6sperm capacitation (GO:0048240)7.76064747
7spermatid nucleus differentiation (GO:0007289)7.35907029
8sexual reproduction (GO:0019953)7.28161643
9single strand break repair (GO:0000012)7.26006224
10plasma membrane fusion (GO:0045026)7.25878904
11sperm-egg recognition (GO:0035036)6.20584279
12spermatid development (GO:0007286)6.15791259
13microtubule depolymerization (GO:0007019)6.14380713
14reproduction (GO:0000003)5.99911541
15negative regulation of inclusion body assembly (GO:0090084)5.93736254
16binding of sperm to zona pellucida (GO:0007339)5.83871686
17multicellular organism reproduction (GO:0032504)5.81270852
18calcium ion-dependent exocytosis (GO:0017156)5.37692339
19cell-cell recognition (GO:0009988)5.36268710
20cellular ketone body metabolic process (GO:0046950)5.11152851
21phosphatidylethanolamine biosynthetic process (GO:0006646)5.01402885
22rRNA methylation (GO:0031167)5.01010861
23positive regulation of Rab GTPase activity (GO:0032851)4.82855191
24regulation of Rab GTPase activity (GO:0032313)4.82855191
25axonemal dynein complex assembly (GO:0070286)4.76207941
26chromatin silencing (GO:0006342)4.74640811
27microtubule polymerization or depolymerization (GO:0031109)4.71523139
28spermatogenesis (GO:0007283)4.66966704
29male gamete generation (GO:0048232)4.65130139
30phosphatidylethanolamine metabolic process (GO:0046337)4.60406157
31protein targeting to Golgi (GO:0000042)4.58525110
32ketone body metabolic process (GO:1902224)4.48146272
33establishment of protein localization to Golgi (GO:0072600)4.39712775
34regulation of T-helper 2 cell differentiation (GO:0045628)4.34100335
35protein polyglutamylation (GO:0018095)4.32854371
36retrograde transport, vesicle recycling within Golgi (GO:0000301)4.20878237
37gamete generation (GO:0007276)4.20126999
38RNA destabilization (GO:0050779)4.06245508
39motile cilium assembly (GO:0044458)4.03483987
40regulation of inclusion body assembly (GO:0090083)3.99512528
41rRNA modification (GO:0000154)3.97848520
42cell wall macromolecule catabolic process (GO:0016998)3.95790450
43* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95620054
44negative regulation of Rho protein signal transduction (GO:0035024)3.87660375
45positive regulation of type 2 immune response (GO:0002830)3.77407265
46single fertilization (GO:0007338)3.70227644
47coenzyme catabolic process (GO:0009109)3.70111237
48cell wall macromolecule metabolic process (GO:0044036)3.69466663
49microtubule severing (GO:0051013)3.68497034
50germ cell development (GO:0007281)3.47187526
51regulation of transcription involved in cell fate commitment (GO:0060850)3.44916660
52cilium or flagellum-dependent cell motility (GO:0001539)3.43807359
53NAD biosynthetic process (GO:0009435)3.39927809
54negative regulation of gene expression, epigenetic (GO:0045814)3.38848859
55multicellular organismal reproductive process (GO:0048609)3.38143667
56cellular process involved in reproduction in multicellular organism (GO:0022412)3.36636250
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31088037
58glycerol ether metabolic process (GO:0006662)3.30467966
59mesenchymal cell differentiation involved in renal system development (GO:2001012)3.28579931
60mesenchymal cell differentiation involved in kidney development (GO:0072161)3.28579931
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28542168
62negative regulation of cell killing (GO:0031342)3.28542168
63regulation of cilium movement (GO:0003352)3.23679494
64regulation of interleukin-13 production (GO:0032656)3.21974776
65nucleus organization (GO:0006997)3.17952145
66regulation of ARF GTPase activity (GO:0032312)3.16026095
67antigen processing and presentation of endogenous antigen (GO:0019883)3.15503400
68centriole replication (GO:0007099)3.15061140
69histone H3-K9 demethylation (GO:0033169)3.12948040
70negative regulation of granulocyte differentiation (GO:0030853)3.10714569
71protein localization to Golgi apparatus (GO:0034067)3.08839878
72cellular response to pH (GO:0071467)3.08323893
73regulation of gamma-delta T cell activation (GO:0046643)3.05889789
74ether metabolic process (GO:0018904)3.03501475
75macrophage activation involved in immune response (GO:0002281)3.02606699
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.01654691
77response to acidic pH (GO:0010447)3.00811371
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00785973
79cell differentiation involved in metanephros development (GO:0072202)3.00684191
80homeostasis of number of cells within a tissue (GO:0048873)2.99553080
81opsonization (GO:0008228)2.96134537
82regulation of somitogenesis (GO:0014807)2.95902386
83regulation of gamma-delta T cell differentiation (GO:0045586)2.91976850
84centriole assembly (GO:0098534)2.89830829
85fertilization (GO:0009566)2.85445705
86positive regulation of gamma-delta T cell activation (GO:0046645)2.82522069
87pyridine nucleotide biosynthetic process (GO:0019363)2.81940434
88nicotinamide nucleotide biosynthetic process (GO:0019359)2.81940434
89peptidyl-proline hydroxylation (GO:0019511)2.79055404
90positive regulation of interleukin-4 production (GO:0032753)2.73754002
91cerebral cortex neuron differentiation (GO:0021895)2.73585396
92peptidyl-threonine dephosphorylation (GO:0035970)2.66886163
93peptide catabolic process (GO:0043171)2.63168753
94positive regulation of interleukin-8 secretion (GO:2000484)2.62989282
95tooth mineralization (GO:0034505)2.59891782
96positive regulation of myotube differentiation (GO:0010831)2.56390550
97positive regulation of T-helper cell differentiation (GO:0045624)2.54574661
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51645841
99seminiferous tubule development (GO:0072520)2.51587595
100acrosome reaction (GO:0007340)10.4694666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.54645460
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.46737806
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40419660
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.13632413
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.88510141
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76728272
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.35506382
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.27965822
9* RUNX_20019798_ChIP-Seq_JUKART_Human2.21357445
10BCL6_27268052_Chip-Seq_Bcells_Human2.11024845
11LXR_22292898_ChIP-Seq_THP-1_Human2.09100898
12BCOR_27268052_Chip-Seq_Bcells_Human1.94814194
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90444435
14ERA_21632823_ChIP-Seq_H3396_Human1.86275702
15E2F1_20622854_ChIP-Seq_HELA_Human1.85160267
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.83125342
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82165132
18DROSHA_22980978_ChIP-Seq_HELA_Human1.78051773
19P68_20966046_ChIP-Seq_HELA_Human1.74113600
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73072693
21RAC3_21632823_ChIP-Seq_H3396_Human1.72375436
22NANOG_20526341_ChIP-Seq_ESCs_Human1.71689437
23SMC4_20622854_ChIP-Seq_HELA_Human1.69033987
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67449972
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62087838
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62087838
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.61355003
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61298939
29PHF8_20622854_ChIP-Seq_HELA_Human1.60531768
30* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.59530101
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57429354
32P300_27268052_Chip-Seq_Bcells_Human1.56296019
33CTCF_27219007_Chip-Seq_Bcells_Human1.54298960
34TP63_22573176_ChIP-Seq_HFKS_Human1.52539245
35CTCF_20526341_ChIP-Seq_ESCs_Human1.51829948
36VDR_24787735_ChIP-Seq_THP-1_Human1.51172105
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.49086528
38* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47979484
39TAF2_19829295_ChIP-Seq_ESCs_Human1.46540767
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.45581532
41SA1_27219007_Chip-Seq_Bcells_Human1.42012463
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41137535
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41076104
44MYB_26560356_Chip-Seq_TH2_Human1.38852098
45MYC_19829295_ChIP-Seq_ESCs_Human1.34626099
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.33942406
47SPI1_23127762_ChIP-Seq_K562_Human1.32546869
48GATA1_19941826_ChIP-Seq_K562_Human1.30737180
49OCT4_20526341_ChIP-Seq_ESCs_Human1.29737526
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26269362
51SMRT_27268052_Chip-Seq_Bcells_Human1.26105903
52CBP_20019798_ChIP-Seq_JUKART_Human1.26035414
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26035414
54STAT1_20625510_ChIP-Seq_HELA_Human1.22501753
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20106407
56CEBPB_22108803_ChIP-Seq_LS180_Human1.18636250
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18285217
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.18134631
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16798954
60MAF_26560356_Chip-Seq_TH2_Human1.16092306
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15943292
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15392387
63KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15270218
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14096350
65UTX_26944678_Chip-Seq_JUKART_Human1.10321157
66SPI1_20517297_ChIP-Seq_HL60_Human1.09381305
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08964528
68* MAF_26560356_Chip-Seq_TH1_Human1.08437758
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08288114
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06837221
71VDR_24763502_ChIP-Seq_THP-1_Human1.05875326
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04810154
73KDM2B_26808549_Chip-Seq_DND41_Human1.04177886
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.04009311
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03846335
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03632903
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.03054184
78OCT4_19829295_ChIP-Seq_ESCs_Human1.02769867
79TCF7_22412390_ChIP-Seq_EML_Mouse1.02448633
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02050335
81P53_21459846_ChIP-Seq_SAOS-2_Human1.01520660
82FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00518417
83MYB_26560356_Chip-Seq_TH1_Human1.00136949
84CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99613824
85GATA3_27048872_Chip-Seq_THYMUS_Human0.99601141
86CTCF_21964334_Chip-Seq_Bcells_Human0.98369098
87* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97965788
88HNFA_21074721_ChIP-Seq_CACO-2_Human0.97871957
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.97389133
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96974344
91ER_23166858_ChIP-Seq_MCF-7_Human0.94905431
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93923166
93FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93686236
94SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93566184
95CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92532093
96BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.92410027
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91997826
98KLF4_19829295_ChIP-Seq_ESCs_Human0.91822742
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91359869
100* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91279176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.68795143
2MP0001348_abnormal_lacrimal_gland3.91748119
3MP0003878_abnormal_ear_physiology3.60273006
4MP0005377_hearing/vestibular/ear_phenot3.60273006
5MP0003698_abnormal_male_reproductive3.07254259
6MP0005670_abnormal_white_adipose3.01455029
7MP0002132_abnormal_respiratory_system2.81939630
8MP0004510_myositis2.69952100
9MP0003436_decreased_susceptibility_to2.64152699
10MP0000678_abnormal_parathyroid_gland2.62389544
11MP0001929_abnormal_gametogenesis2.50166475
12MP0001835_abnormal_antigen_presentation2.48523318
13MP0005671_abnormal_response_to2.36147639
14MP0009785_altered_susceptibility_to2.22055495
15MP0003724_increased_susceptibility_to2.20132238
16MP0003011_delayed_dark_adaptation2.13973623
17MP0002138_abnormal_hepatobiliary_system2.13955779
18MP0000685_abnormal_immune_system2.06857250
19MP0003303_peritoneal_inflammation2.06067508
20MP0005310_abnormal_salivary_gland2.02478852
21MP0001800_abnormal_humoral_immune1.96498411
22MP0005387_immune_system_phenotype1.92035727
23MP0001790_abnormal_immune_system1.92035727
24MP0005000_abnormal_immune_tolerance1.89488295
25MP0005025_abnormal_response_to1.87872646
26MP0006082_CNS_inflammation1.81888707
27MP0002419_abnormal_innate_immunity1.75238627
28MP0002723_abnormal_immune_serum1.74902754
29MP0002452_abnormal_antigen_presenting1.62571749
30MP0002161_abnormal_fertility/fecundity1.57799036
31MP0005379_endocrine/exocrine_gland_phen1.47733570
32MP0003646_muscle_fatigue1.46740389
33MP0002420_abnormal_adaptive_immunity1.45122611
34MP0001819_abnormal_immune_cell1.43463293
35MP0001873_stomach_inflammation1.42680043
36MP0001533_abnormal_skeleton_physiology1.40708080
37MP0004947_skin_inflammation1.33554378
38MP0001765_abnormal_ion_homeostasis1.29361688
39MP0003763_abnormal_thymus_physiology1.26686603
40MP0003172_abnormal_lysosome_physiology1.22521886
41MP0002148_abnormal_hypersensitivity_rea1.21751626
42MP0002249_abnormal_larynx_morphology1.21312371
43MP0009764_decreased_sensitivity_to1.21168801
44MP0005451_abnormal_body_composition1.17524453
45MP0002405_respiratory_system_inflammati1.16121483
46MP0005166_decreased_susceptibility_to1.12068229
47MP0010155_abnormal_intestine_physiology1.07893107
48MP0002254_reproductive_system_inflammat1.06600569
49MP0000716_abnormal_immune_system1.06097162
50MP0008469_abnormal_protein_level1.05737811
51MP0003300_gastrointestinal_ulcer1.05013322
52MP0001845_abnormal_inflammatory_respons1.04019471
53MP0002398_abnormal_bone_marrow1.01385717
54MP0000681_abnormal_thyroid_gland0.98614311
55MP0009333_abnormal_splenocyte_physiolog0.96654491
56MP0003718_maternal_effect0.93626373
57MP0000249_abnormal_blood_vessel0.89393653
58MP0002722_abnormal_immune_system0.88751452
59MP0005248_abnormal_Harderian_gland0.88074008
60MP0004742_abnormal_vestibular_system0.87671358
61MP0002127_abnormal_cardiovascular_syste0.87374904
62MP0000703_abnormal_thymus_morphology0.86014301
63MP0009278_abnormal_bone_marrow0.84999307
64MP0009053_abnormal_anal_canal0.83199803
65MP0003879_abnormal_hair_cell0.82128417
66MP0002998_abnormal_bone_remodeling0.81928168
67MP0002735_abnormal_chemical_nociception0.79000420
68MP0002282_abnormal_trachea_morphology0.78717750
69MP0002429_abnormal_blood_cell0.78058028
70MP0002933_joint_inflammation0.77985360
71MP0000689_abnormal_spleen_morphology0.77103018
72MP0005535_abnormal_body_temperature0.73864681
73MP0005167_abnormal_blood-brain_barrier0.73309188
74MP0003866_abnormal_defecation0.72371625
75MP0001501_abnormal_sleep_pattern0.69071561
76MP0009115_abnormal_fat_cell0.68188996
77MP0002210_abnormal_sex_determination0.66914138
78MP0005464_abnormal_platelet_physiology0.66703189
79MP0005423_abnormal_somatic_nervous0.66418491
80MP0001486_abnormal_startle_reflex0.66304475
81MP0001853_heart_inflammation0.65873759
82MP0001485_abnormal_pinna_reflex0.65662951
83MP0003091_abnormal_cell_migration0.62874455
84MP0005666_abnormal_adipose_tissue0.62857553
85MP0005083_abnormal_biliary_tract0.60119062
86MP0001666_abnormal_nutrient_absorption0.60074781
87MP0001145_abnormal_male_reproductive0.59078337
88MP0002733_abnormal_thermal_nociception0.58710442
89MP0008874_decreased_physiological_sensi0.58666562
90MP0004484_altered_response_of0.58371699
91MP0005636_abnormal_mineral_homeostasis0.57505511
92MP0000470_abnormal_stomach_morphology0.56964497
93MP0005164_abnormal_response_to0.56603607
94MP0005395_other_phenotype0.56492716
95MP0003448_altered_tumor_morphology0.56461333
96MP0005397_hematopoietic_system_phenotyp0.56047064
97MP0001545_abnormal_hematopoietic_system0.56047064
98MP0000604_amyloidosis0.55485866
99MP0000653_abnormal_sex_gland0.53988507
100MP0001963_abnormal_hearing_physiology0.53967104

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.77389080
2Nasal polyposis (HP:0100582)5.08530103
3Absent/shortened dynein arms (HP:0200106)4.80282253
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.80282253
5Asymmetric septal hypertrophy (HP:0001670)4.73092464
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.50537893
7Attenuation of retinal blood vessels (HP:0007843)4.46881218
8Abnormality of the nasal mucosa (HP:0000433)4.33790872
9Bony spicule pigmentary retinopathy (HP:0007737)4.28858018
10Abnormal rod and cone electroretinograms (HP:0008323)4.04061798
11Enlarged epiphyses (HP:0010580)3.75487564
12Hypoplastic ischia (HP:0003175)3.68273275
13Abnormal ciliary motility (HP:0012262)3.58795008
14Resting tremor (HP:0002322)3.54154468
15Potter facies (HP:0002009)3.44528545
16Facial shape deformation (HP:0011334)3.44528545
17Abnormal respiratory motile cilium physiology (HP:0012261)3.36462166
18Bell-shaped thorax (HP:0001591)3.35590715
19Abnormal respiratory epithelium morphology (HP:0012253)3.33521280
20Abnormal respiratory motile cilium morphology (HP:0005938)3.33521280
21Azoospermia (HP:0000027)3.32698710
22Eczematoid dermatitis (HP:0000976)3.25843874
23Infertility (HP:0000789)3.20752974
24Retrobulbar optic neuritis (HP:0100654)3.17073773
25Optic neuritis (HP:0100653)3.17073773
26Recurrent bacterial skin infections (HP:0005406)3.14975490
27Abnormal spermatogenesis (HP:0008669)3.13332257
28Myositis (HP:0100614)3.11733778
29Abnormality of the ischium (HP:0003174)3.08335700
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.07748450
31Orchitis (HP:0100796)3.06567526
32Obstructive lung disease (HP:0006536)3.01797277
33Chronic obstructive pulmonary disease (HP:0006510)3.01797277
34Recurrent abscess formation (HP:0002722)2.98839842
35Abnormality of macrophages (HP:0004311)2.98217970
36Hyperkalemia (HP:0002153)2.87885719
37Male infertility (HP:0003251)2.84262406
38Gastrointestinal infarctions (HP:0005244)2.80600375
39Abnormality of macular pigmentation (HP:0008002)2.76559069
40Unilateral renal agenesis (HP:0000122)2.74282010
41Hypoplasia of the thymus (HP:0000778)2.71849826
42Recurrent pneumonia (HP:0006532)2.67590783
43Gingivitis (HP:0000230)2.64892301
44Elevated erythrocyte sedimentation rate (HP:0003565)2.57027140
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.53598991
46Postural instability (HP:0002172)2.50313470
47Cone-rod dystrophy (HP:0000548)2.47341615
48Hypochromic microcytic anemia (HP:0004840)2.45820269
49Meningitis (HP:0001287)2.43548658
50Tetany (HP:0001281)2.39983764
51Recurrent gram-negative bacterial infections (HP:0005420)2.32255345
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31569399
53Vasculitis (HP:0002633)2.31032108
54Bronchiectasis (HP:0002110)2.29525411
55Recurrent skin infections (HP:0001581)2.28315082
56Abnormal urine output (HP:0012590)2.24137458
57Abnormality of the costochondral junction (HP:0000919)2.23010070
58Slow saccadic eye movements (HP:0000514)2.21649817
59Impulsivity (HP:0100710)2.20105228
60Widely patent fontanelles and sutures (HP:0004492)2.19778426
61Double outlet right ventricle (HP:0001719)2.17427230
62Congenital malformation of the right heart (HP:0011723)2.17427230
63Colitis (HP:0002583)2.15675798
64Abnormality of T cell physiology (HP:0011840)2.15496202
65Recurrent fungal infections (HP:0002841)2.13823458
66Abnormality of the aortic arch (HP:0012303)2.13512302
67Stomatitis (HP:0010280)2.12071746
68Hypochromic anemia (HP:0001931)2.08370588
69Recurrent bronchitis (HP:0002837)2.07619828
70Flattened epiphyses (HP:0003071)2.07329208
71Generalized aminoaciduria (HP:0002909)2.07294265
72Keratoconjunctivitis sicca (HP:0001097)2.05604047
73Hemoptysis (HP:0002105)2.05176631
74Keratoconjunctivitis (HP:0001096)2.05129116
75Abnormality of T cells (HP:0002843)2.01395304
76Hypertensive crisis (HP:0100735)2.00682406
77Epiphyseal dysplasia (HP:0002656)1.98576327
78Abnormality of renal excretion (HP:0011036)1.97732656
79Cellulitis (HP:0100658)1.96156332
80Mediastinal lymphadenopathy (HP:0100721)1.95593007
81Abnormality of potassium homeostasis (HP:0011042)1.92826381
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.92345468
83Recurrent lower respiratory tract infections (HP:0002783)1.92328037
84Ventricular tachycardia (HP:0004756)1.90701443
85Aplasia/Hypoplasia of the thymus (HP:0010515)1.90574269
86Inflammation of the large intestine (HP:0002037)1.89774562
87Pulmonary infiltrates (HP:0002113)1.89528028
88Recurrent sinusitis (HP:0011108)1.89069282
89Encephalitis (HP:0002383)1.88112376
90Hyponatremia (HP:0002902)1.86735385
91Chest pain (HP:0100749)1.86580077
92Seborrheic dermatitis (HP:0001051)1.86481449
93Chronic hepatic failure (HP:0100626)1.85381602
94Gastrointestinal stroma tumor (HP:0100723)1.82544474
95Tubulointerstitial nephritis (HP:0001970)1.80019747
96Protuberant abdomen (HP:0001538)1.78311480
97Renal dysplasia (HP:0000110)1.78071316
98Malnutrition (HP:0004395)1.77117601
99Prolonged bleeding time (HP:0003010)1.74863945
100Gastrointestinal inflammation (HP:0004386)1.74497574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK15.53514734
2PLK45.50567890
3DDR25.11259368
4MAP4K23.32571127
5INSRR3.07462209
6RIPK42.87083634
7MAP4K12.56082267
8STK382.44650330
9BLK1.98171755
10PDPK11.76545058
11BRD41.76544347
12MAPK151.76468760
13PDK11.74429039
14ERN11.73760944
15WNK11.71890544
16MAP3K131.56712419
17MAP3K111.55507969
18TYK21.47360271
19TXK1.46492729
20PLK21.40553883
21CSK1.38812774
22PIK3CG1.36222032
23KSR21.35010332
24PTK2B1.29330389
25DYRK1B1.27174080
26TNK21.26306475
27MST1R1.23461790
28IRAK41.19502742
29SIK21.18066283
30IKBKB1.15333894
31JAK31.15279402
32SYK1.14231858
33MAP3K11.06133801
34PRKD31.05206825
35IKBKE1.01770888
36GRK60.99427597
37BTK0.99219093
38ZAP700.95715097
39CDK120.94211044
40FES0.91331542
41KIT0.88890745
42CAMK1G0.88513572
43PRPF4B0.88045379
44CDK70.87254964
45PRKG20.86756568
46MAP3K90.83241449
47PRKAA20.81322698
48JAK10.79463040
49TBK10.79346876
50CDK40.78746913
51TESK20.78402572
52HCK0.77052158
53RPS6KA20.76467257
54MAP2K20.75630649
55MAP3K140.73865502
56LYN0.73203131
57JAK20.70444238
58MARK20.69235135
59LCK0.68968498
60STK38L0.68349325
61ITK0.67687820
62MAP3K80.66844080
63MARK30.66740328
64MAP3K30.65198673
65RPS6KL10.63204612
66RPS6KC10.63204612
67MAP3K20.60307846
68EPHB10.59903011
69CSF1R0.59171529
70UHMK10.59068021
71RPS6KA60.58719136
72RPS6KA10.58684817
73NEK60.55004039
74MATK0.54494637
75FGFR40.54082971
76RIPK10.53557634
77MAPK110.49644829
78CHUK0.49471213
79MAP3K70.48769141
80FGR0.47860179
81GRK70.46700469
82TAOK10.44819287
83PRKCQ0.44670767
84MAP2K30.43713463
85PRKG10.41824661
86PRKCZ0.39830947
87TAOK30.37780425
88PASK0.37397779
89BRAF0.36061961
90FGFR30.35932643
91TEC0.35413815
92CDC42BPA0.34876385
93FYN0.34536526
94ACVR1B0.34454302
95PNCK0.34024089
96MAPK10.33511218
97CAMK40.33288409
98CAMK1D0.30297653
99STK100.29151460
100TRIB30.28439390

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.83459891
2* Allograft rejection_Homo sapiens_hsa053302.77972285
3* Graft-versus-host disease_Homo sapiens_hsa053322.65570853
4* Autoimmune thyroid disease_Homo sapiens_hsa053202.58582982
5Fatty acid biosynthesis_Homo sapiens_hsa000612.36469303
6* Antigen processing and presentation_Homo sapiens_hsa046122.29609558
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.24114440
8Leishmaniasis_Homo sapiens_hsa051402.18234301
9Olfactory transduction_Homo sapiens_hsa047402.16393875
10* Type I diabetes mellitus_Homo sapiens_hsa049402.15586986
11Staphylococcus aureus infection_Homo sapiens_hsa051502.11192581
12Influenza A_Homo sapiens_hsa051642.02086762
13Primary immunodeficiency_Homo sapiens_hsa053401.97017658
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94011787
15Asthma_Homo sapiens_hsa053101.93893006
16Osteoclast differentiation_Homo sapiens_hsa043801.93049232
17B cell receptor signaling pathway_Homo sapiens_hsa046621.85015521
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75382445
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64652128
20* Viral myocarditis_Homo sapiens_hsa054161.62263267
21Toxoplasmosis_Homo sapiens_hsa051451.56535383
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.52564062
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.37659167
24Dorso-ventral axis formation_Homo sapiens_hsa043201.36771253
25Acute myeloid leukemia_Homo sapiens_hsa052211.36617544
26Type II diabetes mellitus_Homo sapiens_hsa049301.36551883
27Measles_Homo sapiens_hsa051621.36031761
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33243601
29T cell receptor signaling pathway_Homo sapiens_hsa046601.31925185
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.28025645
31Chemokine signaling pathway_Homo sapiens_hsa040621.23602883
32Tuberculosis_Homo sapiens_hsa051521.22535114
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21834325
34Butanoate metabolism_Homo sapiens_hsa006501.16589605
35Hematopoietic cell lineage_Homo sapiens_hsa046401.15120138
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14303999
37* Herpes simplex infection_Homo sapiens_hsa051681.10132185
38Legionellosis_Homo sapiens_hsa051341.06378198
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05752834
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05345212
41Malaria_Homo sapiens_hsa051441.04983159
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.02271599
43TNF signaling pathway_Homo sapiens_hsa046680.93318377
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92131912
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87590724
46* Endocytosis_Homo sapiens_hsa041440.87329286
47VEGF signaling pathway_Homo sapiens_hsa043700.82805626
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82300576
49Renin-angiotensin system_Homo sapiens_hsa046140.78935013
50African trypanosomiasis_Homo sapiens_hsa051430.75556102
51Phenylalanine metabolism_Homo sapiens_hsa003600.75050326
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74305633
53Taste transduction_Homo sapiens_hsa047420.72695542
54Rheumatoid arthritis_Homo sapiens_hsa053230.69728675
55Fat digestion and absorption_Homo sapiens_hsa049750.68907942
56Prolactin signaling pathway_Homo sapiens_hsa049170.67162213
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67011662
58* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63684069
59Inositol phosphate metabolism_Homo sapiens_hsa005620.62979301
60Pertussis_Homo sapiens_hsa051330.61416567
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60718637
62MAPK signaling pathway_Homo sapiens_hsa040100.60434162
63Protein digestion and absorption_Homo sapiens_hsa049740.58558906
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57483350
65Estrogen signaling pathway_Homo sapiens_hsa049150.55887971
66Glycerolipid metabolism_Homo sapiens_hsa005610.53588660
67* Epstein-Barr virus infection_Homo sapiens_hsa051690.50564073
68Hepatitis B_Homo sapiens_hsa051610.49404894
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48023011
70Arginine and proline metabolism_Homo sapiens_hsa003300.47816681
71Linoleic acid metabolism_Homo sapiens_hsa005910.47338585
72Platelet activation_Homo sapiens_hsa046110.47250839
73Salivary secretion_Homo sapiens_hsa049700.46773830
74cAMP signaling pathway_Homo sapiens_hsa040240.45930357
75PPAR signaling pathway_Homo sapiens_hsa033200.45666891
76* Phagosome_Homo sapiens_hsa041450.44379791
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44281006
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43139819
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42543283
80Other glycan degradation_Homo sapiens_hsa005110.41199902
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40607858
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.40607809
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39798558
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.39483268
85Insulin resistance_Homo sapiens_hsa049310.39101204
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.38961247
87Notch signaling pathway_Homo sapiens_hsa043300.37672031
88Apoptosis_Homo sapiens_hsa042100.37639224
89ABC transporters_Homo sapiens_hsa020100.36815632
90Non-small cell lung cancer_Homo sapiens_hsa052230.36681753
91Fatty acid degradation_Homo sapiens_hsa000710.36589185
92Systemic lupus erythematosus_Homo sapiens_hsa053220.35972385
93* Viral carcinogenesis_Homo sapiens_hsa052030.35080034
94Hepatitis C_Homo sapiens_hsa051600.34751433
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32071171
96Calcium signaling pathway_Homo sapiens_hsa040200.30993113
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29366059
98Choline metabolism in cancer_Homo sapiens_hsa052310.28959213
99Retinol metabolism_Homo sapiens_hsa008300.28729184
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28597455

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