HLA-J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59876993
2negative regulation of cell killing (GO:0031342)5.00350210
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00350210
4cytidine metabolic process (GO:0046087)4.93925251
5cytidine catabolic process (GO:0006216)4.93925251
6cytidine deamination (GO:0009972)4.93925251
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84541804
8regulation of T cell mediated cytotoxicity (GO:0001914)4.77327652
9positive regulation of T cell mediated cytotoxicity (GO:0001916)4.69785831
10antigen processing and presentation of endogenous antigen (GO:0019883)4.63519004
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60837569
12DNA deamination (GO:0045006)4.59522961
13pyrimidine ribonucleoside catabolic process (GO:0046133)4.38947523
14cellular response to interleukin-15 (GO:0071350)4.19775693
15regulation of regulatory T cell differentiation (GO:0045589)4.13258849
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.08008504
17positive regulation of tolerance induction (GO:0002645)4.01515070
18regulation of leukocyte mediated cytotoxicity (GO:0001910)4.01133872
19positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.00195423
20positive regulation of defense response to virus by host (GO:0002230)3.85411069
21positive regulation of gamma-delta T cell activation (GO:0046645)3.80371353
22regulation of T cell tolerance induction (GO:0002664)3.72888968
23axonemal dynein complex assembly (GO:0070286)3.70510659
24regulation of cell killing (GO:0031341)3.64652920
25response to interleukin-15 (GO:0070672)3.61539026
26regulation of tolerance induction (GO:0002643)3.59215489
27negative T cell selection (GO:0043383)3.58827047
28regulation of activation of Janus kinase activity (GO:0010533)3.58728543
29regulation of B cell receptor signaling pathway (GO:0050855)3.57739653
30positive regulation of cell killing (GO:0031343)3.55663612
31cilium or flagellum-dependent cell motility (GO:0001539)3.50450334
32positive thymic T cell selection (GO:0045059)3.45672264
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45508176
34GDP-mannose metabolic process (GO:0019673)3.43169964
35interferon-gamma production (GO:0032609)3.42948735
36immunoglobulin mediated immune response (GO:0016064)3.40392716
37tolerance induction (GO:0002507)3.35453207
38regulation of natural killer cell mediated immunity (GO:0002715)3.34528808
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.34528808
40regulation of chronic inflammatory response (GO:0002676)3.33199323
41NIK/NF-kappaB signaling (GO:0038061)3.31909863
42negative thymic T cell selection (GO:0045060)3.31563193
43cellular response to type I interferon (GO:0071357)3.30857685
44type I interferon signaling pathway (GO:0060337)3.30857685
45response to type I interferon (GO:0034340)3.30836178
46positive T cell selection (GO:0043368)3.28981971
47mast cell activation (GO:0045576)3.28028332
48positive regulation of T cell mediated immunity (GO:0002711)3.24875801
49response to interferon-beta (GO:0035456)3.24070707
50regulation of gamma-delta T cell differentiation (GO:0045586)3.22342169
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18416241
52negative regulation of viral genome replication (GO:0045071)3.14318372
53regulation of T cell mediated immunity (GO:0002709)3.10223828
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09826211
55regulation of memory T cell differentiation (GO:0043380)3.09587855
56cilium movement (GO:0003341)3.06261654
57regulation of gamma-delta T cell activation (GO:0046643)3.05668158
58actin nucleation (GO:0045010)3.04281838
59axoneme assembly (GO:0035082)3.01834122
60regulation of alpha-beta T cell proliferation (GO:0046640)3.01621591
61positive regulation of natural killer cell mediated immunity (GO:0002717)2.98610636
62positive regulation of calcium-mediated signaling (GO:0050850)2.97811427
63epithelial cilium movement (GO:0003351)2.95289740
64negative regulation of lymphocyte mediated immunity (GO:0002707)2.94456526
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89623101
66interferon-gamma-mediated signaling pathway (GO:0060333)2.85383876
67regulation of defense response to virus by host (GO:0050691)2.84238243
68B cell mediated immunity (GO:0019724)2.83856390
69negative regulation of T cell apoptotic process (GO:0070233)2.79049010
70negative regulation of alpha-beta T cell activation (GO:0046636)2.77930103
71thymic T cell selection (GO:0045061)2.77809243
72positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.77425112
73negative regulation of T cell mediated immunity (GO:0002710)2.76616503
74positive regulation of T-helper 1 type immune response (GO:0002827)2.76509439
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.75124208
76positive regulation of lymphocyte mediated immunity (GO:0002708)2.74581793
77negative regulation of leukocyte mediated immunity (GO:0002704)2.74210350
78T cell selection (GO:0045058)2.73639460
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73157576
80motile cilium assembly (GO:0044458)2.73069315
81antigen processing and presentation via MHC class Ib (GO:0002475)2.72514696
82positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70934413
83positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.69690443
84mast cell degranulation (GO:0043303)2.66669182
85mast cell activation involved in immune response (GO:0002279)2.66669182
86positive regulation of lymphocyte migration (GO:2000403)2.65005881
87regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.64718157
88cellular defense response (GO:0006968)2.64160328
89positive regulation of interleukin-17 production (GO:0032740)2.63647574
90lymph node development (GO:0048535)2.63471232
91regulation of T-helper 1 type immune response (GO:0002825)2.62318815
92mannose metabolic process (GO:0006013)2.61267798
93regulation of germinal center formation (GO:0002634)2.60496277
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60319631
95activated T cell proliferation (GO:0050798)2.58982174
96positive regulation of adaptive immune response (GO:0002821)2.58591496
97regulation of lymphocyte mediated immunity (GO:0002706)2.57819104
98positive regulation of natural killer cell differentiation (GO:0032825)2.57402427
99regulation of T cell migration (GO:2000404)2.56583390
100T cell costimulation (GO:0031295)2.56300514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.94520434
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.25214756
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.79814582
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97237484
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65754316
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51019968
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.00180633
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85332536
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77934704
10RUNX_20019798_ChIP-Seq_JUKART_Human2.71303191
11MYB_26560356_Chip-Seq_TH2_Human2.36621751
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25079690
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09103568
14GATA3_27048872_Chip-Seq_THYMUS_Human2.01145795
15GATA3_26560356_Chip-Seq_TH2_Human2.00566898
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98522844
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96731820
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.69257400
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67351628
20MYB_26560356_Chip-Seq_TH1_Human1.60611723
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59406391
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56621104
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49925224
24BCL6_27268052_Chip-Seq_Bcells_Human1.48857667
25LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48758168
26UTX_26944678_Chip-Seq_JUKART_Human1.48184748
27NANOG_20526341_ChIP-Seq_ESCs_Human1.43687934
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43008562
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42364502
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41876449
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38466052
32IGF1R_20145208_ChIP-Seq_DFB_Human1.38057624
33STAT1_20625510_ChIP-Seq_HELA_Human1.37983085
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37979703
35MAF_26560356_Chip-Seq_TH1_Human1.37222312
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36754059
37SPI1_23547873_ChIP-Seq_NB4_Human1.36390953
38P300_27268052_Chip-Seq_Bcells_Human1.34875786
39MAF_26560356_Chip-Seq_TH2_Human1.31417113
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30094690
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29121863
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.27482151
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27482151
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26891367
45ZNF274_21170338_ChIP-Seq_K562_Hela1.25549709
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24707650
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.22972505
48VDR_22108803_ChIP-Seq_LS180_Human1.21966865
49RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21878214
50TAF2_19829295_ChIP-Seq_ESCs_Human1.21398449
51TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21202400
52GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20815678
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19947055
54AR_20517297_ChIP-Seq_VCAP_Human1.19880607
55MYC_19829295_ChIP-Seq_ESCs_Human1.18339755
56E2F1_20622854_ChIP-Seq_HELA_Human1.17537696
57CTCF_20526341_ChIP-Seq_ESCs_Human1.16918814
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.16816353
59BCOR_27268052_Chip-Seq_Bcells_Human1.15226621
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11570807
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11109619
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09327829
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.09200522
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09059323
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.07563435
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06648930
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05083848
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.04196979
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.03890389
70ERG_20517297_ChIP-Seq_VCAP_Human1.03554781
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03553564
72SA1_27219007_Chip-Seq_Bcells_Human1.03267462
73SPI1_23127762_ChIP-Seq_K562_Human1.01811515
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00880165
75VDR_24787735_ChIP-Seq_THP-1_Human1.00051976
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99861309
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98768190
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.97668485
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.97249533
80VDR_23849224_ChIP-Seq_CD4+_Human0.97221765
81ERA_21632823_ChIP-Seq_H3396_Human0.96974266
82RAC3_21632823_ChIP-Seq_H3396_Human0.96856704
83TP53_22573176_ChIP-Seq_HFKS_Human0.96768803
84IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96595329
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.96315586
86OCT4_20526341_ChIP-Seq_ESCs_Human0.96031857
87RUNX1_22412390_ChIP-Seq_EML_Mouse0.95513527
88NCOR_22424771_ChIP-Seq_293T_Human0.94681592
89GATA3_26560356_Chip-Seq_TH1_Human0.93096246
90SMRT_27268052_Chip-Seq_Bcells_Human0.90669890
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90296213
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88990257
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87510012
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86107638
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86032502
96VDR_24763502_ChIP-Seq_THP-1_Human0.85309349
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85163430
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85077992
99RBPJ_21746931_ChIP-Seq_IB4_Human0.84855164
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84668605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.66025567
2MP0001835_abnormal_antigen_presentation3.98725211
3MP0003436_decreased_susceptibility_to3.07995531
4MP0001790_abnormal_immune_system3.05353803
5MP0005387_immune_system_phenotype3.05353803
6MP0009785_altered_susceptibility_to3.04536939
7MP0003724_increased_susceptibility_to2.94214729
8MP0005000_abnormal_immune_tolerance2.87833215
9MP0002148_abnormal_hypersensitivity_rea2.84578226
10MP0000685_abnormal_immune_system2.82433155
11MP0001800_abnormal_humoral_immune2.77019866
12MP0003763_abnormal_thymus_physiology2.75609348
13MP0005025_abnormal_response_to2.51996101
14MP0002723_abnormal_immune_serum2.51135423
15MP0006082_CNS_inflammation2.39742968
16MP0010155_abnormal_intestine_physiology2.31354888
17MP0002420_abnormal_adaptive_immunity2.27084364
18MP0001819_abnormal_immune_cell2.24845971
19MP0002452_abnormal_antigen_presenting2.19898455
20MP0009333_abnormal_splenocyte_physiolog2.10514348
21MP0002419_abnormal_innate_immunity1.89195691
22MP0001873_stomach_inflammation1.78499458
23MP0003866_abnormal_defecation1.78069493
24MP0001845_abnormal_inflammatory_respons1.77961593
25MP0008875_abnormal_xenobiotic_pharmacok1.76565360
26MP0002405_respiratory_system_inflammati1.75398225
27MP0002138_abnormal_hepatobiliary_system1.75361406
28MP0009764_decreased_sensitivity_to1.71901197
29MP0000716_abnormal_immune_system1.70683644
30MP0001533_abnormal_skeleton_physiology1.67267513
31MP0004043_abnormal_pH_regulation1.65112192
32MP0002638_abnormal_pupillary_reflex1.64825416
33MP0002398_abnormal_bone_marrow1.64027569
34MP0002166_altered_tumor_susceptibility1.59680271
35MP0002876_abnormal_thyroid_physiology1.57046981
36MP0004147_increased_porphyrin_level1.56622403
37MP0002139_abnormal_hepatobiliary_system1.52211846
38MP0002933_joint_inflammation1.51585395
39MP0001501_abnormal_sleep_pattern1.50841538
40MP0005464_abnormal_platelet_physiology1.49572329
41MP0002277_abnormal_respiratory_mucosa1.45049708
42MP0004947_skin_inflammation1.41662457
43MP0008469_abnormal_protein_level1.41273389
44MP0000689_abnormal_spleen_morphology1.40640570
45MP0002722_abnormal_immune_system1.37682461
46MP0003646_muscle_fatigue1.36786780
47MP0002006_tumorigenesis1.33034143
48MP0002132_abnormal_respiratory_system1.32257463
49MP0002429_abnormal_blood_cell1.28161027
50MP0005645_abnormal_hypothalamus_physiol1.27176104
51MP0005075_abnormal_melanosome_morpholog1.23391511
52MP0000703_abnormal_thymus_morphology1.20165817
53MP0006072_abnormal_retinal_apoptosis1.19103879
54MP0008872_abnormal_physiological_respon1.16847346
55MP0005360_urolithiasis1.15947584
56MP0003878_abnormal_ear_physiology1.15271627
57MP0005377_hearing/vestibular/ear_phenot1.15271627
58MP0003303_peritoneal_inflammation1.12328671
59MP0000465_gastrointestinal_hemorrhage1.10977033
60MP0005410_abnormal_fertilization1.08360932
61MP0001765_abnormal_ion_homeostasis1.06473044
62MP0002837_dystrophic_cardiac_calcinosis1.05581279
63MP0002693_abnormal_pancreas_physiology1.00854431
64MP0005166_decreased_susceptibility_to1.00336512
65MP0003806_abnormal_nucleotide_metabolis0.99101794
66MP0001919_abnormal_reproductive_system0.93466332
67MP0003075_altered_response_to0.91785506
68MP0009840_abnormal_foam_cell0.89953398
69MP0001853_heart_inflammation0.89487698
70MP0005310_abnormal_salivary_gland0.89460135
71MP0001986_abnormal_taste_sensitivity0.88834431
72MP0003195_calcinosis0.87879067
73MP0005174_abnormal_tail_pigmentation0.86940071
74MP0009643_abnormal_urine_homeostasis0.84641046
75MP0002136_abnormal_kidney_physiology0.83885739
76MP0009763_increased_sensitivity_to0.83040898
77MP0005167_abnormal_blood-brain_barrier0.80786596
78MP0002254_reproductive_system_inflammat0.79576705
79MP0004019_abnormal_vitamin_homeostasis0.78546316
80MP0005365_abnormal_bile_salt0.77941629
81MP0005646_abnormal_pituitary_gland0.77135216
82MP0005636_abnormal_mineral_homeostasis0.76739870
83MP0005253_abnormal_eye_physiology0.76687014
84MP0000372_irregular_coat_pigmentation0.75789240
85MP0005379_endocrine/exocrine_gland_phen0.75569503
86MP0001764_abnormal_homeostasis0.74171193
87MP0005389_reproductive_system_phenotype0.73198339
88MP0001663_abnormal_digestive_system0.72293493
89MP0005535_abnormal_body_temperature0.70709412
90MP0001905_abnormal_dopamine_level0.70044425
91MP0002998_abnormal_bone_remodeling0.69628098
92MP0002653_abnormal_ependyma_morphology0.68518268
93MP0006036_abnormal_mitochondrial_physio0.68098658
94MP0005551_abnormal_eye_electrophysiolog0.67921485
95MP0005390_skeleton_phenotype0.66076087
96MP0002102_abnormal_ear_morphology0.65342310
97MP0000230_abnormal_systemic_arterial0.65237872
98MP0005085_abnormal_gallbladder_physiolo0.64470260
99MP0002163_abnormal_gland_morphology0.64219037
100MP0010329_abnormal_lipoprotein_level0.63729234

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.86019681
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.55291756
3Absent/shortened dynein arms (HP:0200106)4.55291756
4Abnormality of T cell number (HP:0011839)4.11223746
5T lymphocytopenia (HP:0005403)4.08380773
6Myositis (HP:0100614)3.97997643
7IgG deficiency (HP:0004315)3.91651888
8Abnormal respiratory epithelium morphology (HP:0012253)3.88217931
9Abnormal respiratory motile cilium morphology (HP:0005938)3.88217931
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87369714
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.83475190
12Abnormal ciliary motility (HP:0012262)3.72928320
13Abnormal respiratory motile cilium physiology (HP:0012261)3.57820279
14Stomatitis (HP:0010280)3.55039745
15Orchitis (HP:0100796)3.33183343
16Severe combined immunodeficiency (HP:0004430)3.30933217
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.30563741
18Abnormality of T cells (HP:0002843)3.28478442
19Abnormal rod and cone electroretinograms (HP:0008323)3.25902417
20Optic neuritis (HP:0100653)3.24629758
21Retrobulbar optic neuritis (HP:0100654)3.24629758
22Bronchiectasis (HP:0002110)3.20538992
23Nasal polyposis (HP:0100582)3.15537103
24Increased IgM level (HP:0003496)3.12838538
25Abnormality of eosinophils (HP:0001879)3.11395404
26Rhinitis (HP:0012384)3.07694790
27Recurrent bronchitis (HP:0002837)2.92053544
28Eosinophilia (HP:0001880)2.91002203
29Hypoproteinemia (HP:0003075)2.85637948
30Congenital stationary night blindness (HP:0007642)2.84870100
31Chronic sinusitis (HP:0011109)2.76355742
32Bronchitis (HP:0012387)2.70773689
33Thyroiditis (HP:0100646)2.70579087
34Abnormality of the nasal mucosa (HP:0000433)2.69984279
35Encephalitis (HP:0002383)2.69364036
36Abnormality of B cell number (HP:0010975)2.63120717
373-Methylglutaconic aciduria (HP:0003535)2.62101484
38Autoimmune hemolytic anemia (HP:0001890)2.61279084
39Granulocytopenia (HP:0001913)2.58946292
40Recurrent cutaneous fungal infections (HP:0011370)2.57435796
41Chronic mucocutaneous candidiasis (HP:0002728)2.57435796
42Abnormality of T cell physiology (HP:0011840)2.56088483
43Pulmonary infiltrates (HP:0002113)2.55733052
44Recurrent sinusitis (HP:0011108)2.55277886
45Leukocytosis (HP:0001974)2.54781607
46Vasculitis (HP:0002633)2.52699737
47Panhypogammaglobulinemia (HP:0003139)2.51883854
48Chronic diarrhea (HP:0002028)2.46537743
49Pustule (HP:0200039)2.43965934
50Recurrent fungal infections (HP:0002841)2.43959596
51Combined immunodeficiency (HP:0005387)2.43076483
52Chronic bronchitis (HP:0004469)2.39821172
53Chronic otitis media (HP:0000389)2.39376542
54Meningitis (HP:0001287)2.32551907
55Decreased central vision (HP:0007663)2.26862672
56Gastrointestinal infarctions (HP:0005244)2.20543426
57Constricted visual fields (HP:0001133)2.19860782
58Abnormality of the renal cortex (HP:0011035)2.19663194
59Keratoconjunctivitis (HP:0001096)2.17741418
60Mediastinal lymphadenopathy (HP:0100721)2.17548040
61Keratoconjunctivitis sicca (HP:0001097)2.13158459
62Decreased circulating renin level (HP:0003351)2.11424524
63B lymphocytopenia (HP:0010976)2.09341069
64Attenuation of retinal blood vessels (HP:0007843)2.09017303
65Joint swelling (HP:0001386)2.07132302
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02754245
67Pancreatic cysts (HP:0001737)2.01464540
68Autoimmune thrombocytopenia (HP:0001973)2.00747781
69Hemoptysis (HP:0002105)1.99113021
70Type II lissencephaly (HP:0007260)1.98484785
71Hypergammaglobulinemia (HP:0010702)1.96302868
72Renal cortical cysts (HP:0000803)1.95293096
73Abnormality of macrophages (HP:0004311)1.94721448
74Abnormality of the pleura (HP:0002103)1.94274073
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93072092
76Abnormality of midbrain morphology (HP:0002418)1.92899457
77Molar tooth sign on MRI (HP:0002419)1.92899457
78Abolished electroretinogram (ERG) (HP:0000550)1.90634690
79Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90333648
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90333648
81Recurrent skin infections (HP:0001581)1.90035247
82Nephronophthisis (HP:0000090)1.89755633
83Global brain atrophy (HP:0002283)1.89491988
84Recurrent viral infections (HP:0004429)1.88535403
85Eczematoid dermatitis (HP:0000976)1.87110504
86Recurrent bacterial skin infections (HP:0005406)1.85626043
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85419867
88Polydipsia (HP:0001959)1.84592675
89Abnormal drinking behavior (HP:0030082)1.84592675
90Agammaglobulinemia (HP:0004432)1.84234640
91Recurrent otitis media (HP:0000403)1.79201929
92Inflammation of the large intestine (HP:0002037)1.79152156
93Recurrent abscess formation (HP:0002722)1.78170491
94Increased intramyocellular lipid droplets (HP:0012240)1.77783980
95Pulmonary embolism (HP:0002204)1.76999838
96Gangrene (HP:0100758)1.75944067
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74440026
98Abnormality of the prostate (HP:0008775)1.74054239
99Alkalosis (HP:0001948)1.73766020
100Anorexia (HP:0002039)1.72130587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.64644013
2MAP4K13.58873417
3TLK13.40351291
4TAOK32.72243529
5TESK22.60281759
6ADRBK22.46988080
7KDR2.43522774
8GRK62.26301663
9PINK12.25129761
10FES2.21011412
11RIPK42.14786811
12ZAK1.99373191
13IKBKE1.98314558
14TBK11.92455365
15ERN11.92352849
16ZAP701.88026033
17FRK1.84577492
18ITK1.77879031
19MAP4K21.76667901
20TIE11.72205222
21GRK11.71821870
22SYK1.68110810
23KIT1.66958573
24WNK41.62873484
25IKBKB1.60025663
26TEC1.57784950
27MAP2K61.56975826
28CSK1.54944443
29MAP3K141.54567364
30LCK1.54408274
31BTK1.49461155
32BCKDK1.46434901
33IRAK41.42164538
34JAK31.41200969
35PRKCQ1.38886890
36MAPK151.35552724
37TYK21.31222823
38MST41.28590338
39ACVR1B1.25553332
40TNK21.25322675
41TESK11.20815790
42MAP2K21.18635243
43MATK1.12864995
44JAK11.10709136
45MAP3K111.09195840
46CSF1R1.06808340
47LYN1.05770806
48MAPKAPK30.99080256
49MARK30.97904419
50GRK70.96815532
51DAPK20.95657679
52LIMK10.94700334
53HCK0.92338860
54NUAK10.89783467
55BMPR20.84407719
56BLK0.80331412
57CAMKK20.71789811
58PIM10.69123610
59VRK10.68420203
60MUSK0.66888367
61PASK0.59512120
62EPHA30.57315502
63PDK10.54917787
64VRK20.54649193
65TRPM70.54537471
66PTK2B0.54251240
67RPS6KA50.52762262
68MAPK110.48652101
69MAP3K30.48078894
70PHKG20.45878425
71PHKG10.45878425
72INSRR0.45682195
73IGF1R0.45653023
74MYLK0.44522355
75NLK0.42652962
76ABL10.42595806
77ADRBK10.39816110
78FYN0.39125754
79BMPR1B0.38766753
80CSNK1G30.38519165
81HIPK20.35828090
82CDC42BPA0.35673376
83CHUK0.34871569
84EPHB10.34645533
85PRKCA0.32032773
86MAPKAPK20.31599732
87PRKCD0.31030890
88EGFR0.30964306
89IRAK10.30909973
90CDK80.30587529
91DAPK10.30318099
92JAK20.30124357
93PIM20.27779475
94SIK20.27355975
95INSR0.26723998
96PRKCI0.25822573
97PRKG20.25061985
98WNK30.24401130
99PDPK10.23419373
100CAMKK10.23270524

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.07135519
2Allograft rejection_Homo sapiens_hsa053303.94553612
3Graft-versus-host disease_Homo sapiens_hsa053323.88646162
4Autoimmune thyroid disease_Homo sapiens_hsa053203.74358191
5Type I diabetes mellitus_Homo sapiens_hsa049403.34424291
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.19693116
7Asthma_Homo sapiens_hsa053102.94407127
8Antigen processing and presentation_Homo sapiens_hsa046122.86326682
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44399142
10Hematopoietic cell lineage_Homo sapiens_hsa046402.27368810
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13988907
12Rheumatoid arthritis_Homo sapiens_hsa053231.91836595
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91084784
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.87108253
15Staphylococcus aureus infection_Homo sapiens_hsa051501.80252628
16Sulfur metabolism_Homo sapiens_hsa009201.61910070
17Viral myocarditis_Homo sapiens_hsa054161.60420064
18T cell receptor signaling pathway_Homo sapiens_hsa046601.59665058
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58834801
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51126460
21Linoleic acid metabolism_Homo sapiens_hsa005911.50122219
22Leishmaniasis_Homo sapiens_hsa051401.49955936
23Caffeine metabolism_Homo sapiens_hsa002321.43161480
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31545497
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27416446
26Proteasome_Homo sapiens_hsa030501.23847588
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22161543
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21623434
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20928932
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20925953
31Phototransduction_Homo sapiens_hsa047441.18237450
32Measles_Homo sapiens_hsa051621.15999796
33Herpes simplex infection_Homo sapiens_hsa051681.08833794
34Chemical carcinogenesis_Homo sapiens_hsa052041.07704263
35Oxidative phosphorylation_Homo sapiens_hsa001901.05706797
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05491889
37Malaria_Homo sapiens_hsa051441.03025767
38Arachidonic acid metabolism_Homo sapiens_hsa005901.02777621
39Tryptophan metabolism_Homo sapiens_hsa003801.02365183
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97091706
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95187642
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.94139336
43Nitrogen metabolism_Homo sapiens_hsa009100.92067523
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90994555
45Peroxisome_Homo sapiens_hsa041460.90405124
46Tuberculosis_Homo sapiens_hsa051520.88476709
47Osteoclast differentiation_Homo sapiens_hsa043800.88419639
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86099577
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80578542
50African trypanosomiasis_Homo sapiens_hsa051430.77501182
51ABC transporters_Homo sapiens_hsa020100.76708149
52Pertussis_Homo sapiens_hsa051330.75812196
53TNF signaling pathway_Homo sapiens_hsa046680.75667655
54Retinol metabolism_Homo sapiens_hsa008300.70412667
55Olfactory transduction_Homo sapiens_hsa047400.69335660
56Butanoate metabolism_Homo sapiens_hsa006500.68453529
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.67948182
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.66773583
59Toxoplasmosis_Homo sapiens_hsa051450.66123100
60Influenza A_Homo sapiens_hsa051640.65360459
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.64522286
62Legionellosis_Homo sapiens_hsa051340.63844148
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62786938
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61420889
65Lysosome_Homo sapiens_hsa041420.60590250
66Parkinsons disease_Homo sapiens_hsa050120.60514185
67Chemokine signaling pathway_Homo sapiens_hsa040620.60099295
68Regulation of autophagy_Homo sapiens_hsa041400.59777952
69Fat digestion and absorption_Homo sapiens_hsa049750.55611626
70Collecting duct acid secretion_Homo sapiens_hsa049660.54455797
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53705100
72Ether lipid metabolism_Homo sapiens_hsa005650.52115429
73Phagosome_Homo sapiens_hsa041450.50436136
74Systemic lupus erythematosus_Homo sapiens_hsa053220.49185849
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.49144290
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48310945
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47756766
78B cell receptor signaling pathway_Homo sapiens_hsa046620.46817854
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45549314
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44566286
81Huntingtons disease_Homo sapiens_hsa050160.41765091
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40294718
83Mineral absorption_Homo sapiens_hsa049780.37796637
84Phenylalanine metabolism_Homo sapiens_hsa003600.37587576
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35910713
86Alzheimers disease_Homo sapiens_hsa050100.35908048
87Other glycan degradation_Homo sapiens_hsa005110.35316603
88Shigellosis_Homo sapiens_hsa051310.31594260
89Salmonella infection_Homo sapiens_hsa051320.31275117
90Histidine metabolism_Homo sapiens_hsa003400.29309894
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28740582
92Apoptosis_Homo sapiens_hsa042100.25938817
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.25356492
94Hepatitis C_Homo sapiens_hsa051600.23290428
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.23275160
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23011988
97Selenocompound metabolism_Homo sapiens_hsa004500.22424326
98RNA degradation_Homo sapiens_hsa030180.21075607
99Sphingolipid metabolism_Homo sapiens_hsa006000.20395184
100Tyrosine metabolism_Homo sapiens_hsa003500.20240196

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