HLA-K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95036082
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78943093
3antigen processing and presentation of endogenous antigen (GO:0019883)5.55984686
4negative regulation of cell killing (GO:0031342)5.38125381
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.38125381
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.17524852
7cellular response to type I interferon (GO:0071357)4.21680155
8type I interferon signaling pathway (GO:0060337)4.21680155
9response to type I interferon (GO:0034340)4.16484843
10regulation of T cell mediated cytotoxicity (GO:0001914)4.16256516
11positive regulation of T cell mediated cytotoxicity (GO:0001916)4.12459136
12response to interferon-beta (GO:0035456)4.09019957
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05779156
14immunoglobulin mediated immune response (GO:0016064)3.90856994
15positive regulation of gamma-delta T cell activation (GO:0046645)3.83478611
16NIK/NF-kappaB signaling (GO:0038061)3.69360673
17regulation of chronic inflammatory response (GO:0002676)3.66887497
18regulation of dendritic cell antigen processing and presentation (GO:0002604)3.61978826
19regulation of T cell tolerance induction (GO:0002664)3.57418792
20positive regulation of defense response to virus by host (GO:0002230)3.55559668
21regulation of regulatory T cell differentiation (GO:0045589)3.51963931
22positive regulation of antigen processing and presentation (GO:0002579)3.50277988
23regulation of T-helper 1 cell differentiation (GO:0045625)3.49426048
24interferon-gamma-mediated signaling pathway (GO:0060333)3.47942192
25regulation of B cell receptor signaling pathway (GO:0050855)3.47444346
26regulation of leukocyte mediated cytotoxicity (GO:0001910)3.42178828
27positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.30469721
28regulation of alpha-beta T cell proliferation (GO:0046640)3.29941878
29detection of bacterium (GO:0016045)3.28598969
30regulation of antigen processing and presentation (GO:0002577)3.25486085
31negative regulation of viral genome replication (GO:0045071)3.20135344
32positive regulation of natural killer cell differentiation (GO:0032825)3.17595773
33regulation of cell killing (GO:0031341)3.16241244
34cellular response to interleukin-15 (GO:0071350)3.15783569
35regulation of cellular extravasation (GO:0002691)3.14659129
36regulation of tolerance induction (GO:0002643)3.14422979
37response to interleukin-15 (GO:0070672)3.12869509
38detection of other organism (GO:0098543)3.10269220
39positive regulation of tolerance induction (GO:0002645)3.09341473
40regulation of gamma-delta T cell activation (GO:0046643)3.06708297
41cytidine deamination (GO:0009972)3.03421447
42cytidine metabolic process (GO:0046087)3.03421447
43cytidine catabolic process (GO:0006216)3.03421447
44B cell mediated immunity (GO:0019724)3.03414515
45positive regulation of alpha-beta T cell proliferation (GO:0046641)3.00454566
46positive regulation of cell killing (GO:0031343)2.97761589
47negative regulation of interleukin-12 production (GO:0032695)2.96375419
48regulation of natural killer cell mediated immunity (GO:0002715)2.96235826
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.96235826
50positive regulation of T cell mediated immunity (GO:0002711)2.95417069
51cellular response to interferon-beta (GO:0035458)2.94717895
52negative T cell selection (GO:0043383)2.90500423
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90445176
54lymph node development (GO:0048535)2.90062777
55negative regulation of lymphocyte mediated immunity (GO:0002707)2.89768189
56regulation of T cell mediated immunity (GO:0002709)2.88872894
57myeloid dendritic cell differentiation (GO:0043011)2.88609653
58T-helper 1 type immune response (GO:0042088)2.88278482
59negative thymic T cell selection (GO:0045060)2.87860348
60regulation of defense response to virus by host (GO:0050691)2.87575745
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87142779
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85661274
63negative regulation of leukocyte mediated immunity (GO:0002704)2.84500672
64regulation of gamma-delta T cell differentiation (GO:0045586)2.83881668
65defense response to protozoan (GO:0042832)2.83708598
66positive regulation of interleukin-17 production (GO:0032740)2.83279202
67negative regulation of T cell mediated immunity (GO:0002710)2.80556711
68interferon-gamma secretion (GO:0072643)2.80171000
69positive thymic T cell selection (GO:0045059)2.77204209
70negative regulation of innate immune response (GO:0045824)2.76953813
71cellular response to interferon-gamma (GO:0071346)2.76444647
72regulation of interferon-alpha production (GO:0032647)2.76335292
73response to interferon-alpha (GO:0035455)2.74527562
74positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.73386736
75cytokine biosynthetic process (GO:0042089)2.72866041
76response to interferon-gamma (GO:0034341)2.71492253
77regulation of interferon-beta biosynthetic process (GO:0045357)2.69621583
78leukocyte aggregation (GO:0070486)2.68129891
79antigen processing and presentation via MHC class Ib (GO:0002475)2.67125116
80myeloid dendritic cell activation (GO:0001773)2.66069723
81positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.65602433
82positive regulation of isotype switching (GO:0045830)2.64367506
83response to protozoan (GO:0001562)2.62926585
84regulation of interleukin-12 production (GO:0032655)2.62924812
85positive regulation of interferon-alpha production (GO:0032727)2.62876659
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62793717
87negative regulation of cytokine production involved in immune response (GO:0002719)2.62723161
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62286903
89pyrimidine ribonucleoside catabolic process (GO:0046133)2.61979031
90regulation of memory T cell differentiation (GO:0043380)2.61641931
91positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.61534577
92germinal center formation (GO:0002467)2.61227936
93mast cell activation (GO:0045576)2.60432124
94positive regulation of lymphocyte mediated immunity (GO:0002708)2.60129578
95regulation of T-helper 1 type immune response (GO:0002825)2.59652538
96regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.59223622
97mature B cell differentiation involved in immune response (GO:0002313)2.58194886
98positive regulation of adaptive immune response (GO:0002821)2.55953595
99lymphocyte chemotaxis (GO:0048247)2.55789164
100positive regulation of interferon-gamma production (GO:0032729)2.54927638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.79461818
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.85249184
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.76794701
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80106420
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.58172772
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58056226
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.35892054
8STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88794770
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.75598598
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38423787
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35703165
12RUNX_20019798_ChIP-Seq_JUKART_Human2.33429037
13MYB_26560356_Chip-Seq_TH2_Human2.33411319
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.30975644
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26594742
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12584158
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11221607
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08616779
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04095538
20MAF_26560356_Chip-Seq_TH1_Human1.92950892
21SPI1_23547873_ChIP-Seq_NB4_Human1.92080771
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90286382
23MYB_26560356_Chip-Seq_TH1_Human1.85611356
24VDR_24763502_ChIP-Seq_THP-1_Human1.84157328
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78805052
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78221566
27UTX_26944678_Chip-Seq_JUKART_Human1.70765538
28VDR_21846776_ChIP-Seq_THP-1_Human1.70094565
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65076893
30BCL6_27268052_Chip-Seq_Bcells_Human1.63941584
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63576930
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.60847369
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58796268
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58137377
35SPI1_23127762_ChIP-Seq_K562_Human1.57061397
36MAF_26560356_Chip-Seq_TH2_Human1.54477291
37GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52041931
38GATA3_26560356_Chip-Seq_TH2_Human1.49748981
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49235383
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48950701
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47670432
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46315393
43BCOR_27268052_Chip-Seq_Bcells_Human1.43424571
44GATA3_27048872_Chip-Seq_THYMUS_Human1.42487388
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36549625
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32328512
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.31078133
48STAT1_20625510_ChIP-Seq_HELA_Human1.26080293
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25505731
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.25247596
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24768203
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20586007
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20273672
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20145144
55P300_27268052_Chip-Seq_Bcells_Human1.19537939
56MYC_22102868_ChIP-Seq_BL_Human1.18317976
57SCL_19346495_ChIP-Seq_HPC-7_Human1.17802633
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17388334
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15657537
60LXR_22292898_ChIP-Seq_THP-1_Human1.15135808
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14891873
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14140728
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11569373
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10926359
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10554044
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08119217
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07164930
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06675368
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06547458
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05762457
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.01590165
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01270973
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00924285
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00778797
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99162114
76CTCF_26484167_Chip-Seq_Bcells_Mouse0.98533197
77GATA1_19941827_ChIP-Seq_MEL_Mouse0.97883551
78SA1_27219007_Chip-Seq_Bcells_Human0.97194147
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97189120
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96608121
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.96174603
82VDR_24787735_ChIP-Seq_THP-1_Human0.95745421
83SPI1_20517297_ChIP-Seq_HL60_Human0.95379259
84P68_20966046_ChIP-Seq_HELA_Human0.94783884
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94333847
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91466125
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90936077
88E2F1_20622854_ChIP-Seq_HELA_Human0.90747403
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90543614
90CTCF_20526341_ChIP-Seq_ESCs_Human0.89748275
91NANOG_20526341_ChIP-Seq_ESCs_Human0.87912477
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87891907
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87666536
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87180084
95RXR_22158963_ChIP-Seq_LIVER_Mouse0.84708258
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83420394
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83188343
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80643927
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80555119
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80379510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.10554012
2MP0003436_decreased_susceptibility_to3.90304238
3MP0005671_abnormal_response_to3.47102933
4MP0009785_altered_susceptibility_to3.42098862
5MP0003724_increased_susceptibility_to3.30569588
6MP0002148_abnormal_hypersensitivity_rea3.14701298
7MP0005387_immune_system_phenotype3.11467895
8MP0001790_abnormal_immune_system3.11467895
9MP0005000_abnormal_immune_tolerance2.97677094
10MP0000685_abnormal_immune_system2.94683897
11MP0003303_peritoneal_inflammation2.85011153
12MP0005025_abnormal_response_to2.74111182
13MP0001800_abnormal_humoral_immune2.72931782
14MP0010155_abnormal_intestine_physiology2.71490515
15MP0006082_CNS_inflammation2.69711629
16MP0002723_abnormal_immune_serum2.54001303
17MP0002452_abnormal_antigen_presenting2.40014416
18MP0002419_abnormal_innate_immunity2.34754535
19MP0003763_abnormal_thymus_physiology2.34378633
20MP0002420_abnormal_adaptive_immunity2.26609500
21MP0001819_abnormal_immune_cell2.26125118
22MP0009333_abnormal_splenocyte_physiolog2.20989807
23MP0001533_abnormal_skeleton_physiology2.11033943
24MP0001845_abnormal_inflammatory_respons1.94974148
25MP0009840_abnormal_foam_cell1.91995754
26MP0002405_respiratory_system_inflammati1.86899678
27MP0009764_decreased_sensitivity_to1.83018127
28MP0005360_urolithiasis1.81101922
29MP0001873_stomach_inflammation1.79100858
30MP0004947_skin_inflammation1.78331056
31MP0002138_abnormal_hepatobiliary_system1.77943556
32MP0000716_abnormal_immune_system1.71654514
33MP0003191_abnormal_cellular_cholesterol1.69050191
34MP0003866_abnormal_defecation1.67641533
35MP0003806_abnormal_nucleotide_metabolis1.64784319
36MP0004510_myositis1.64072915
37MP0002398_abnormal_bone_marrow1.63753741
38MP0008469_abnormal_protein_level1.62315612
39MP0005058_abnormal_lysosome_morphology1.61409272
40MP0005464_abnormal_platelet_physiology1.56294316
41MP0003300_gastrointestinal_ulcer1.51896146
42MP0000689_abnormal_spleen_morphology1.45807863
43MP0005083_abnormal_biliary_tract1.44148867
44MP0002166_altered_tumor_susceptibility1.42946782
45MP0000858_altered_metastatic_potential1.42192206
46MP0002722_abnormal_immune_system1.40227329
47MP0005365_abnormal_bile_salt1.40092519
48MP0002139_abnormal_hepatobiliary_system1.39975970
49MP0003075_altered_response_to1.38138933
50MP0002429_abnormal_blood_cell1.37584440
51MP0002006_tumorigenesis1.35110903
52MP0001853_heart_inflammation1.32809520
53MP0002933_joint_inflammation1.29874111
54MP0005166_decreased_susceptibility_to1.26399686
55MP0005085_abnormal_gallbladder_physiolo1.22096126
56MP0005310_abnormal_salivary_gland1.17258461
57MP0002998_abnormal_bone_remodeling1.16393020
58MP0005451_abnormal_body_composition1.14986763
59MP0000703_abnormal_thymus_morphology1.13549084
60MP0009278_abnormal_bone_marrow1.11087524
61MP0000343_altered_response_to1.10412473
62MP0003011_delayed_dark_adaptation1.10278889
63MP0000465_gastrointestinal_hemorrhage1.08068325
64MP0005165_increased_susceptibility_to1.07610994
65MP0001663_abnormal_digestive_system1.07087613
66MP0001501_abnormal_sleep_pattern1.03362016
67MP0009763_increased_sensitivity_to0.95839696
68MP0005390_skeleton_phenotype0.94504166
69MP0001764_abnormal_homeostasis0.93299428
70MP0005167_abnormal_blood-brain_barrier0.91199384
71MP0000490_abnormal_crypts_of0.90933460
72MP0002254_reproductive_system_inflammat0.90415172
73MP0002132_abnormal_respiratory_system0.88008741
74MP0005084_abnormal_gallbladder_morpholo0.87225331
75MP0002876_abnormal_thyroid_physiology0.84092810
76MP0003172_abnormal_lysosome_physiology0.83581941
77MP0003448_altered_tumor_morphology0.82872460
78MP0000249_abnormal_blood_vessel0.82123571
79MP0000604_amyloidosis0.80558665
80MP0003656_abnormal_erythrocyte_physiolo0.78165146
81MP0001545_abnormal_hematopoietic_system0.77714747
82MP0005397_hematopoietic_system_phenotyp0.77714747
83MP0008875_abnormal_xenobiotic_pharmacok0.74903310
84MP0003183_abnormal_peptide_metabolism0.74600524
85MP0009643_abnormal_urine_homeostasis0.74464362
86MP0001666_abnormal_nutrient_absorption0.73590382
87MP0002277_abnormal_respiratory_mucosa0.72769088
88MP0002693_abnormal_pancreas_physiology0.71023576
89MP0002136_abnormal_kidney_physiology0.70116631
90MP0005381_digestive/alimentary_phenotyp0.64545049
91MP0000609_abnormal_liver_physiology0.64400572
92MP0001765_abnormal_ion_homeostasis0.63896006
93MP0005164_abnormal_response_to0.63116240
94MP0005319_abnormal_enzyme/_coenzyme0.62634537
95MP0009765_abnormal_xenobiotic_induced0.62454881
96MP0005410_abnormal_fertilization0.60652975
97MP0004147_increased_porphyrin_level0.59496525
98MP0003045_fibrosis0.58780225
99MP0003795_abnormal_bone_structure0.58178498
100MP0002019_abnormal_tumor_incidence0.57361385

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.85598808
2Myositis (HP:0100614)4.50038745
3Orchitis (HP:0100796)4.26771630
4Retrobulbar optic neuritis (HP:0100654)4.00102050
5Optic neuritis (HP:0100653)4.00102050
6T lymphocytopenia (HP:0005403)3.76406911
7Abnormality of T cell number (HP:0011839)3.73731917
8Stomatitis (HP:0010280)3.72998686
9Increased IgM level (HP:0003496)3.70928078
10IgG deficiency (HP:0004315)3.66292775
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.48799066
12Recurrent fungal infections (HP:0002841)3.43971739
13Eczematoid dermatitis (HP:0000976)3.42974127
14Pulmonary infiltrates (HP:0002113)3.35699424
15Vasculitis (HP:0002633)3.31453583
16Encephalitis (HP:0002383)3.25310378
17Abnormality of macrophages (HP:0004311)3.24123891
18Abnormality of T cells (HP:0002843)3.16623293
19Recurrent cutaneous fungal infections (HP:0011370)3.13482578
20Chronic mucocutaneous candidiasis (HP:0002728)3.13482578
21Meningitis (HP:0001287)3.11926411
22Pustule (HP:0200039)3.10262246
23Recurrent abscess formation (HP:0002722)3.09928364
24Gastrointestinal infarctions (HP:0005244)3.07224798
25Chronic diarrhea (HP:0002028)3.04989108
26Mediastinal lymphadenopathy (HP:0100721)3.04936851
27Recurrent bacterial skin infections (HP:0005406)3.03742685
28Recurrent viral infections (HP:0004429)2.95879673
29Abnormality of B cell number (HP:0010975)2.91730512
30Panhypogammaglobulinemia (HP:0003139)2.90863958
31Systemic lupus erythematosus (HP:0002725)2.87530712
32Abnormality of liposaccharide metabolism (HP:0010968)2.81108236
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.81108236
34Abnormality of glycolipid metabolism (HP:0010969)2.81108236
35Keratoconjunctivitis sicca (HP:0001097)2.80529740
36Recurrent bronchitis (HP:0002837)2.78111081
37Hemoptysis (HP:0002105)2.78072160
38Inflammation of the large intestine (HP:0002037)2.72864954
39Abnormality of T cell physiology (HP:0011840)2.72444817
40Keratoconjunctivitis (HP:0001096)2.71110782
41Recurrent skin infections (HP:0001581)2.65231910
42Nasal polyposis (HP:0100582)2.61177792
43Agammaglobulinemia (HP:0004432)2.60544473
44Autoimmune thrombocytopenia (HP:0001973)2.59751667
45Hypergammaglobulinemia (HP:0010702)2.59387889
46Colitis (HP:0002583)2.58791569
47Amyloidosis (HP:0011034)2.57063548
48Granulocytopenia (HP:0001913)2.56045142
49Gastrointestinal inflammation (HP:0004386)2.52636636
50Autoimmune hemolytic anemia (HP:0001890)2.50924520
51Severe combined immunodeficiency (HP:0004430)2.50760249
52Abnormality of the pleura (HP:0002103)2.49933835
53Abnormality of the nasal mucosa (HP:0000433)2.49036792
54Chronic otitis media (HP:0000389)2.48831413
55Vacuolated lymphocytes (HP:0001922)2.48315438
56B lymphocytopenia (HP:0010976)2.45441036
57Eosinophilia (HP:0001880)2.45185368
58Obstructive lung disease (HP:0006536)2.44504646
59Chronic obstructive pulmonary disease (HP:0006510)2.44504646
60Chest pain (HP:0100749)2.43810747
61Joint swelling (HP:0001386)2.43369602
62Increased IgE level (HP:0003212)2.42340222
63Gangrene (HP:0100758)2.40843235
64Dysostosis multiplex (HP:0000943)2.40439946
65Abnormality of eosinophils (HP:0001879)2.40261560
66Leukocytosis (HP:0001974)2.36586166
67Anorexia (HP:0002039)2.35785723
68Urticaria (HP:0001025)2.32622889
69IgA deficiency (HP:0002720)2.31452023
70Petechiae (HP:0000967)2.30701699
71IgM deficiency (HP:0002850)2.26979686
72Increased serum ferritin (HP:0003281)2.26120640
73Increased cerebral lipofuscin (HP:0011813)2.24603118
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.21713711
75Glomerulopathy (HP:0100820)2.18618530
76Polyneuropathy (HP:0001271)2.16947847
77Hepatosplenomegaly (HP:0001433)2.16286151
78Skin rash (HP:0000988)2.16114325
79Recurrent gram-negative bacterial infections (HP:0005420)2.14447610
80Premature loss of primary teeth (HP:0006323)2.11208887
81Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07189016
82Arterial thrombosis (HP:0004420)2.06086323
83Abnormality of the pericardium (HP:0001697)2.02821274
84Pancreatitis (HP:0001733)2.01897775
85Gastrointestinal stroma tumor (HP:0100723)2.01660696
86Combined immunodeficiency (HP:0005387)2.01100139
87Arthralgia (HP:0002829)2.00103606
88Abnormality of iron homeostasis (HP:0011031)1.98643605
89Epistaxis (HP:0000421)1.96114398
90Pulmonary embolism (HP:0002204)1.93770717
91Hypochromic anemia (HP:0001931)1.89719947
92Loss of speech (HP:0002371)1.89584735
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.88800886
94Lymphopenia (HP:0001888)1.88563963
95Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88206502
96Abnormality of polysaccharide metabolism (HP:0011012)1.88206502
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88206502
98Abnormality of the prostate (HP:0008775)1.87615841
99Pulmonary fibrosis (HP:0002206)1.87453211
100Purpura (HP:0000979)1.86644597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.61331076
2MAP4K13.39775101
3ERN13.28746188
4TESK23.04563243
5RIPK42.84837615
6MAP3K142.68336250
7TYK22.53499635
8TBK12.49128731
9NME22.42311192
10TESK12.19854693
11IKBKE2.17767756
12VRK22.15007323
13IRAK32.11877625
14TAOK32.04594970
15IKBKB2.03359131
16FES1.85621437
17TLK11.83063494
18JAK11.75090467
19EPHA21.72255899
20GRK61.67503641
21JAK31.67415702
22IRAK41.66449328
23HIPK21.63861432
24CSK1.59783135
25KIT1.59548438
26ACVR1B1.51571076
27ZAP701.44848953
28PIM21.34736692
29BTK1.31957093
30GRK71.29059387
31MATK1.28301534
32BLK1.27736161
33ITK1.26752617
34MST1R1.26377424
35SYK1.25494609
36BCKDK1.24301655
37TEC1.21879289
38PRPF4B1.19638937
39TAOK21.19386641
40KDR1.18459691
41BMPR21.16310165
42MAP3K111.11602162
43MAP3K31.11019043
44EPHB11.08236834
45ADRBK21.07459148
46LCK1.06503763
47LYN1.00241795
48NME10.99935332
49CSF1R0.99537958
50TIE10.98844840
51MAPKAPK30.97735159
52MST40.96066453
53PRKCQ0.92958733
54HCK0.92559073
55SIK30.92231914
56ARAF0.91833583
57MAP2K60.91690178
58LIMK10.91434866
59PTK2B0.88880711
60MARK30.84792584
61MAP2K20.81746711
62DAPK10.80886255
63STK100.80310929
64TGFBR20.79869347
65MAP2K30.78294838
66DAPK20.73847751
67CHUK0.69554939
68MAP3K130.68885933
69JAK20.67507489
70FGFR40.61695418
71VRK10.59797551
72MAPK110.59429934
73TAOK10.57239466
74NUAK10.55779985
75EPHA30.53748236
76PTK60.51486587
77CDC42BPA0.50775175
78IRAK10.49494184
79PIM10.48806835
80LMTK20.48614172
81GRK10.47761985
82TNK20.46972893
83SMG10.46110330
84SIK20.45585185
85MAPK70.45460668
86PDK10.44261037
87PRKG20.43333658
88RIPK10.43250500
89FGR0.42938296
90MAPKAPK20.42251964
91MAP3K10.40745043
92SCYL20.38745770
93MOS0.36196839
94ABL20.35413819
95CDK40.32493160
96FYN0.30035890
97PDPK10.28929645
98ABL10.28628166
99BMX0.28351439
100ZAK0.27971496

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.02624101
2Graft-versus-host disease_Homo sapiens_hsa053323.72239861
3Autoimmune thyroid disease_Homo sapiens_hsa053203.65633517
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.43743398
5Asthma_Homo sapiens_hsa053103.27750790
6Primary immunodeficiency_Homo sapiens_hsa053403.20315079
7Type I diabetes mellitus_Homo sapiens_hsa049402.94613185
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.85206843
9Antigen processing and presentation_Homo sapiens_hsa046122.81610555
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.47444952
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40988958
12Leishmaniasis_Homo sapiens_hsa051402.27585733
13Staphylococcus aureus infection_Homo sapiens_hsa051502.19463796
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01327637
15Hematopoietic cell lineage_Homo sapiens_hsa046401.99477460
16Rheumatoid arthritis_Homo sapiens_hsa053231.98459831
17Viral myocarditis_Homo sapiens_hsa054161.86614382
18Herpes simplex infection_Homo sapiens_hsa051681.69167520
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67968498
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62184737
21Other glycan degradation_Homo sapiens_hsa005111.59961008
22Measles_Homo sapiens_hsa051621.58234708
23Osteoclast differentiation_Homo sapiens_hsa043801.58055312
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55953234
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53056442
26Tuberculosis_Homo sapiens_hsa051521.44807274
27Toxoplasmosis_Homo sapiens_hsa051451.39371206
28Influenza A_Homo sapiens_hsa051641.35360324
29TNF signaling pathway_Homo sapiens_hsa046681.34154412
30Pertussis_Homo sapiens_hsa051331.31489520
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26489667
32Malaria_Homo sapiens_hsa051441.24075216
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.19893766
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.19864312
35African trypanosomiasis_Homo sapiens_hsa051431.17292910
36T cell receptor signaling pathway_Homo sapiens_hsa046601.13736991
37Sulfur metabolism_Homo sapiens_hsa009201.08584448
38Lysosome_Homo sapiens_hsa041421.07784481
39B cell receptor signaling pathway_Homo sapiens_hsa046621.03405824
40Proteasome_Homo sapiens_hsa030501.03006121
41Legionellosis_Homo sapiens_hsa051341.01480578
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94819604
43Hepatitis C_Homo sapiens_hsa051600.93335117
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.92653894
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86721778
46Shigellosis_Homo sapiens_hsa051310.83670762
47Chemokine signaling pathway_Homo sapiens_hsa040620.81078616
48Apoptosis_Homo sapiens_hsa042100.79639880
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77961252
50Caffeine metabolism_Homo sapiens_hsa002320.77488787
51Arachidonic acid metabolism_Homo sapiens_hsa005900.75575651
52Galactose metabolism_Homo sapiens_hsa000520.74683266
53Phagosome_Homo sapiens_hsa041450.71913415
54Fructose and mannose metabolism_Homo sapiens_hsa000510.70372328
55Mineral absorption_Homo sapiens_hsa049780.68177259
56Epstein-Barr virus infection_Homo sapiens_hsa051690.67196983
57Salmonella infection_Homo sapiens_hsa051320.66958760
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65898980
59Fat digestion and absorption_Homo sapiens_hsa049750.64866830
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.60799040
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59044204
62Hepatitis B_Homo sapiens_hsa051610.57186115
63Tryptophan metabolism_Homo sapiens_hsa003800.54208438
64Vitamin digestion and absorption_Homo sapiens_hsa049770.49152747
65Acute myeloid leukemia_Homo sapiens_hsa052210.48590582
66Chemical carcinogenesis_Homo sapiens_hsa052040.48258043
67Renin-angiotensin system_Homo sapiens_hsa046140.46697120
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.46066976
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45809490
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.45366883
71Linoleic acid metabolism_Homo sapiens_hsa005910.44699485
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44212276
73HTLV-I infection_Homo sapiens_hsa051660.42764669
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42066604
75Complement and coagulation cascades_Homo sapiens_hsa046100.40273572
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.39190927
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37106065
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36830036
79Glutathione metabolism_Homo sapiens_hsa004800.36724830
80Pentose phosphate pathway_Homo sapiens_hsa000300.35170761
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33891233
82Systemic lupus erythematosus_Homo sapiens_hsa053220.33437818
83Glycerolipid metabolism_Homo sapiens_hsa005610.33281266
84Retinol metabolism_Homo sapiens_hsa008300.32298058
85Sulfur relay system_Homo sapiens_hsa041220.29212549
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27556690
87Endocytosis_Homo sapiens_hsa041440.27073311
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26286707
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26048188
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.24054152
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22352625
92Starch and sucrose metabolism_Homo sapiens_hsa005000.22345056
93Salivary secretion_Homo sapiens_hsa049700.21859913
94Viral carcinogenesis_Homo sapiens_hsa052030.21564072
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19357736
96Sphingolipid metabolism_Homo sapiens_hsa006000.18124326
97Platelet activation_Homo sapiens_hsa046110.15754728
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.14305472
99PPAR signaling pathway_Homo sapiens_hsa033200.13259689
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12747730

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