ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tryptophan catabolic process (GO:0006569)	5.29390324
2	indole-containing compound catabolic process (GO:0042436)	5.29390324
3	indolalkylamine catabolic process (GO:0046218)	5.29390324
4	indolalkylamine metabolic process (GO:0006586)	4.66396555
5	kynurenine metabolic process (GO:0070189)	4.43628075
6	tryptophan metabolic process (GO:0006568)	4.31950242
7	DNA deamination (GO:0045006)	4.05550000
8	signal peptide processing (GO:0006465)	3.83789452
9	L-fucose catabolic process (GO:0042355)	3.80614017
10	fucose catabolic process (GO:0019317)	3.80614017
11	L-fucose metabolic process (GO:0042354)	3.80614017
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.70146984
13	behavioral response to nicotine (GO:0035095)	3.65937760
14	response to pheromone (GO:0019236)	3.56123252
15	protein K11-linked deubiquitination (GO:0035871)	3.53642212
16	cytidine deamination (GO:0009972)	3.49999483
17	cytidine metabolic process (GO:0046087)	3.49999483
18	cytidine catabolic process (GO:0006216)	3.49999483
19	neural tube formation (GO:0001841)	3.43584333
20	cellular biogenic amine catabolic process (GO:0042402)	3.41211928
21	amine catabolic process (GO:0009310)	3.41211928
22	sulfation (GO:0051923)	3.39064991
23	indole-containing compound metabolic process (GO:0042430)	3.27704630
24	tachykinin receptor signaling pathway (GO:0007217)	3.26228272
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.22261238
26	detection of light stimulus involved in visual perception (GO:0050908)	3.22261238
27	NAD biosynthetic process (GO:0009435)	3.17313475
28	regulation of B cell receptor signaling pathway (GO:0050855)	3.17205240
29	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.08868730
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.08697453
31	establishment of protein localization to Golgi (GO:0072600)	3.07270911
32	photoreceptor cell maintenance (GO:0045494)	3.07036761
33	negative regulation of mast cell activation (GO:0033004)	3.06638316
34	regulation of memory T cell differentiation (GO:0043380)	3.05466199
35	positive regulation of defense response to virus by host (GO:0002230)	3.02040167
36	benzene-containing compound metabolic process (GO:0042537)	3.00479023
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99384238
38	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.96314518
39	monoubiquitinated protein deubiquitination (GO:0035520)	2.96014068
40	retinal cone cell development (GO:0046549)	2.94197564
41	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.93198020
42	DNA demethylation (GO:0080111)	2.86517171
43	positive regulation of developmental pigmentation (GO:0048087)	2.85515334
44	piRNA metabolic process (GO:0034587)	2.83591032
45	regulation of hippo signaling (GO:0035330)	2.83583386
46	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.82034099
47	cellular ketone body metabolic process (GO:0046950)	2.77273932
48	behavioral response to ethanol (GO:0048149)	2.75209488
49	DNA double-strand break processing (GO:0000729)	2.74131246
50	protein K48-linked deubiquitination (GO:0071108)	2.73132471
51	reflex (GO:0060004)	2.67754790
52	aromatic amino acid family catabolic process (GO:0009074)	2.65727360
53	ketone body metabolic process (GO:1902224)	2.65380133
54	multicellular organism reproduction (GO:0032504)	2.65294788
55	cellular response to interleukin-15 (GO:0071350)	2.64488589
56	protein prenylation (GO:0018342)	2.60396398
57	prenylation (GO:0097354)	2.60396398
58	auditory receptor cell stereocilium organization (GO:0060088)	2.58775657
59	adenosine metabolic process (GO:0046085)	2.58313827
60	S-adenosylmethionine metabolic process (GO:0046500)	2.57895911
61	axoneme assembly (GO:0035082)	2.57839895
62	gamma-aminobutyric acid transport (GO:0015812)	2.57410231
63	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.57140571
64	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.57140571
65	regulation of translation, ncRNA-mediated (GO:0045974)	2.57140571
66	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.53881521
67	regulation of establishment of cell polarity (GO:2000114)	2.53857430
68	protein K63-linked deubiquitination (GO:0070536)	2.50668796
69	amino acid salvage (GO:0043102)	2.50055501
70	L-methionine salvage (GO:0071267)	2.50055501
71	L-methionine biosynthetic process (GO:0071265)	2.50055501
72	rRNA catabolic process (GO:0016075)	2.49037657
73	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.48432914
74	adaptation of signaling pathway (GO:0023058)	2.46254571
75	double-strand break repair via homologous recombination (GO:0000724)	2.41449898
76	recombinational repair (GO:0000725)	2.41248146
77	thyroid hormone metabolic process (GO:0042403)	2.40520361
78	regulation of pigment cell differentiation (GO:0050932)	2.39839002
79	preassembly of GPI anchor in ER membrane (GO:0016254)	2.38669312
80	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.38423388
81	regulation of MHC class I biosynthetic process (GO:0045343)	2.37439566
82	proline transport (GO:0015824)	2.36914757
83	photoreceptor cell development (GO:0042461)	2.36884228
84	regulation of gene silencing by RNA (GO:0060966)	2.35918554
85	regulation of posttranscriptional gene silencing (GO:0060147)	2.35918554
86	regulation of gene silencing by miRNA (GO:0060964)	2.35918554
87	mannosylation (GO:0097502)	2.34788109
88	methionine biosynthetic process (GO:0009086)	2.33976732
89	positive regulation of prostaglandin secretion (GO:0032308)	2.33668407
90	protein targeting to Golgi (GO:0000042)	2.31964786
91	cellular response to ethanol (GO:0071361)	2.31137323
92	DNA dealkylation (GO:0035510)	2.31049087
93	regulation of sarcomere organization (GO:0060297)	2.30855641
94	aromatic amino acid family metabolic process (GO:0009072)	2.30217857
95	neuronal action potential (GO:0019228)	2.30109284
96	regulation of defense response to virus by host (GO:0050691)	2.29247153
97	regulation of action potential (GO:0098900)	2.28398117
98	positive regulation of fatty acid transport (GO:2000193)	2.27799125
99	male meiosis (GO:0007140)	2.26407537
100	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.26106624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.22007114
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16580423
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.14235096
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03139887
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.59537487
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59218924
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52641444
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49409809
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48157986
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.28001071
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.21189311
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20096720
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.18025805
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15525247
15	P300_19829295_ChIP-Seq_ESCs_Human	2.03345082
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.01504132
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.00442264
18	FUS_26573619_Chip-Seq_HEK293_Human	1.98955545
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95725522
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94399608
21	EWS_26573619_Chip-Seq_HEK293_Human	1.90758822
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.84002728
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.80466287
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.80408560
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72706878
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72194031
27	STAT3_23295773_ChIP-Seq_U87_Human	1.69070643
28	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.68638151
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64354397
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.64354397
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63300873
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61629237
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.60822710
34	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60574421
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60121575
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54437055
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49646227
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49379724
39	TCF4_23295773_ChIP-Seq_U87_Human	1.49338550
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45718630
41	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.44211775
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44041491
43	AR_25329375_ChIP-Seq_VCAP_Human	1.42991820
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42991334
45	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.42705752
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42462467
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40997522
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.37779700
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37517267
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37231478
51	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36897703
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36519587
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36243227
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32254529
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30955249
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30808027
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30808027
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29676868
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29211644
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28759775
61	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.28019672
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27780752
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27678408
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27336609
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26960559
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26398849
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26398849
68	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24788199
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24275870
70	AR_21572438_ChIP-Seq_LNCaP_Human	1.24164115
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.23191152
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.22095647
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21752770
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21279595
75	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20693418
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20160517
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19041139
78	GATA3_26560356_Chip-Seq_TH2_Human	1.18987488
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17051767
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16827200
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16157942
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.15853551
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15663288
84	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14040684
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13972380
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13972380
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08188386
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08046522
89	AR_20517297_ChIP-Seq_VCAP_Human	1.07541174
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07187507
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06734091
92	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.03859799
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03825002
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02827280
95	RXR_22108803_ChIP-Seq_LS180_Human	1.02657468
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01905126
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00774047
98	NCOR_22424771_ChIP-Seq_293T_Human	0.98447418
99	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.97662359
100	KDM2B_26808549_Chip-Seq_REH_Human	0.96691242

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.31679956
2	MP0003195_calcinosis	3.25506505
3	MP0008877_abnormal_DNA_methylation	2.61882971
4	MP0001501_abnormal_sleep_pattern	2.56430442
5	MP0005671_abnormal_response_to	2.48357796
6	MP0005551_abnormal_eye_electrophysiolog	2.43176521
7	MP0003646_muscle_fatigue	2.25095945
8	MP0008057_abnormal_DNA_replication	2.21634997
9	MP0002102_abnormal_ear_morphology	2.20917037
10	MP0000372_irregular_coat_pigmentation	2.20096434
11	MP0002736_abnormal_nociception_after	2.05596939
12	MP0006072_abnormal_retinal_apoptosis	2.01133009
13	MP0005253_abnormal_eye_physiology	1.99882056
14	MP0009046_muscle_twitch	1.93063828
15	MP0001968_abnormal_touch/_nociception	1.92866225
16	MP0004043_abnormal_pH_regulation	1.88392265
17	MP0002138_abnormal_hepatobiliary_system	1.81637461
18	MP0008872_abnormal_physiological_respon	1.78880279
19	MP0005174_abnormal_tail_pigmentation	1.69105374
20	MP0005646_abnormal_pituitary_gland	1.64027613
21	MP0003252_abnormal_bile_duct	1.63200405
22	MP0002876_abnormal_thyroid_physiology	1.62878179
23	MP0003787_abnormal_imprinting	1.60948981
24	MP0001835_abnormal_antigen_presentation	1.57980587
25	MP0005075_abnormal_melanosome_morpholog	1.57256330
26	MP0009745_abnormal_behavioral_response	1.56173960
27	MP0003950_abnormal_plasma_membrane	1.53038736
28	MP0004147_increased_porphyrin_level	1.52068284
29	MP0005645_abnormal_hypothalamus_physiol	1.51664886
30	MP0003136_yellow_coat_color	1.46694297
31	MP0000427_abnormal_hair_cycle	1.42140381
32	MP0004142_abnormal_muscle_tone	1.42135953
33	MP0010386_abnormal_urinary_bladder	1.41971316
34	MP0001800_abnormal_humoral_immune	1.41723186
35	MP0005310_abnormal_salivary_gland	1.41360484
36	MP0003045_fibrosis	1.38804689
37	MP0001986_abnormal_taste_sensitivity	1.37931291
38	MP0002837_dystrophic_cardiac_calcinosis	1.36802088
39	MP0003763_abnormal_thymus_physiology	1.33518157
40	MP0000685_abnormal_immune_system	1.29572205
41	MP0001485_abnormal_pinna_reflex	1.28411992
42	MP0002638_abnormal_pupillary_reflex	1.24582471
43	MP0006054_spinal_hemorrhage	1.23832935
44	MP0003724_increased_susceptibility_to	1.23270731
45	MP0001984_abnormal_olfaction	1.21641131
46	MP0009785_altered_susceptibility_to	1.21196831
47	MP0001764_abnormal_homeostasis	1.19826515
48	MP0002272_abnormal_nervous_system	1.16708910
49	MP0001486_abnormal_startle_reflex	1.11979869
50	MP0002693_abnormal_pancreas_physiology	1.11459843
51	MP0000015_abnormal_ear_pigmentation	1.11120881
52	MP0001790_abnormal_immune_system	1.10375145
53	MP0005387_immune_system_phenotype	1.10375145
54	MP0002723_abnormal_immune_serum	1.10295091
55	MP0002095_abnormal_skin_pigmentation	1.09976977
56	MP0006292_abnormal_olfactory_placode	1.09442765
57	MP0005379_endocrine/exocrine_gland_phen	1.08648663
58	MP0009764_decreased_sensitivity_to	1.08209658
59	MP0005410_abnormal_fertilization	1.07349583
60	MP0006082_CNS_inflammation	1.05728968
61	MP0002163_abnormal_gland_morphology	1.04879007
62	MP0002148_abnormal_hypersensitivity_rea	1.04474733
63	MP0001873_stomach_inflammation	1.02574375
64	MP0000631_abnormal_neuroendocrine_gland	1.01739985
65	MP0003718_maternal_effect	0.99275372
66	MP0005386_behavior/neurological_phenoty	0.97983181
67	MP0004924_abnormal_behavior	0.97983181
68	MP0005000_abnormal_immune_tolerance	0.97881176
69	MP0000371_diluted_coat_color	0.96080216
70	MP0002928_abnormal_bile_duct	0.95166010
71	MP0002452_abnormal_antigen_presenting	0.94640824
72	MP0002420_abnormal_adaptive_immunity	0.94564750
73	MP0005377_hearing/vestibular/ear_phenot	0.94537554
74	MP0003878_abnormal_ear_physiology	0.94537554
75	MP0000230_abnormal_systemic_arterial	0.94264964
76	MP0001819_abnormal_immune_cell	0.92228964
77	MP0008961_abnormal_basal_metabolism	0.89508035
78	MP0000538_abnormal_urinary_bladder	0.88208423
79	MP0004145_abnormal_muscle_electrophysio	0.87031684
80	MP0002572_abnormal_emotion/affect_behav	0.85410316
81	MP0002168_other_aberrant_phenotype	0.83881757
82	MP0002405_respiratory_system_inflammati	0.83636549
83	MP0008058_abnormal_DNA_repair	0.83582388
84	MP0005167_abnormal_blood-brain_barrier	0.83520416
85	MP0002067_abnormal_sensory_capabilities	0.81221659
86	MP0006276_abnormal_autonomic_nervous	0.80914706
87	MP0008995_early_reproductive_senescence	0.80785804
88	MP0004885_abnormal_endolymph	0.80155130
89	MP0000689_abnormal_spleen_morphology	0.79562841
90	MP0005085_abnormal_gallbladder_physiolo	0.79440940
91	MP0002229_neurodegeneration	0.79001129
92	MP0005266_abnormal_metabolism	0.78460519
93	MP0004215_abnormal_myocardial_fiber	0.77900019
94	MP0002064_seizures	0.77656390
95	MP0001970_abnormal_pain_threshold	0.77257213
96	MP0002938_white_spotting	0.75977458
97	MP0002735_abnormal_chemical_nociception	0.75928264
98	MP0005395_other_phenotype	0.74852712
99	MP0002733_abnormal_thermal_nociception	0.73258761
100	MP0003633_abnormal_nervous_system	0.73130525

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.33436213
2	Congenital stationary night blindness (HP:0007642)	4.00471987
3	Gaze-evoked nystagmus (HP:0000640)	3.84361013
4	Pancreatic fibrosis (HP:0100732)	3.79452058
5	True hermaphroditism (HP:0010459)	3.62391418
6	Genetic anticipation (HP:0003743)	3.54831334
7	Attenuation of retinal blood vessels (HP:0007843)	3.38707125
8	Abnormality of midbrain morphology (HP:0002418)	3.38085809
9	Molar tooth sign on MRI (HP:0002419)	3.38085809
10	Chronic hepatic failure (HP:0100626)	3.36152712
11	Progressive cerebellar ataxia (HP:0002073)	3.22194502
12	Abnormality of the renal cortex (HP:0011035)	3.18976418
13	Hyperventilation (HP:0002883)	3.15548500
14	Nephronophthisis (HP:0000090)	3.13531100
15	Thyroiditis (HP:0100646)	2.91559968
16	Abnormality of the renal medulla (HP:0100957)	2.91435065
17	Abolished electroretinogram (ERG) (HP:0000550)	2.84497440
18	IgG deficiency (HP:0004315)	2.73980596
19	Medial flaring of the eyebrow (HP:0010747)	2.71394087
20	Stomach cancer (HP:0012126)	2.69471653
21	Cystic liver disease (HP:0006706)	2.49730923
22	Clumsiness (HP:0002312)	2.45819937
23	Hypoproteinemia (HP:0003075)	2.40845042
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.40610264
25	Congenital sensorineural hearing impairment (HP:0008527)	2.37623650
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.34123910
27	Abnormality of B cell number (HP:0010975)	2.31630904
28	Protruding tongue (HP:0010808)	2.31144737
29	Renal cortical cysts (HP:0000803)	2.28158536
30	Abnormality of T cell number (HP:0011839)	2.27003696
31	Bile duct proliferation (HP:0001408)	2.25698895
32	Abnormal biliary tract physiology (HP:0012439)	2.25698895
33	Severe combined immunodeficiency (HP:0004430)	2.24376124
34	Decreased central vision (HP:0007663)	2.23082691
35	Tubular atrophy (HP:0000092)	2.22267781
36	Febrile seizures (HP:0002373)	2.21647652
37	Polydipsia (HP:0001959)	2.16660359
38	Abnormal drinking behavior (HP:0030082)	2.16660359
39	Inability to walk (HP:0002540)	2.16376019
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16262735
41	Hypothermia (HP:0002045)	2.16238170
42	Congenital hepatic fibrosis (HP:0002612)	2.15158225
43	Stomatitis (HP:0010280)	2.14659252
44	Increased corneal curvature (HP:0100692)	2.12534792
45	Keratoconus (HP:0000563)	2.12534792
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12176060
47	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.10984295
48	Abnormality of macular pigmentation (HP:0008002)	2.09859290
49	Fair hair (HP:0002286)	2.09775328
50	Pendular nystagmus (HP:0012043)	2.07121742
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06609339
52	Absent speech (HP:0001344)	2.06000250
53	Ketosis (HP:0001946)	2.05058907
54	Progressive inability to walk (HP:0002505)	2.04332252
55	Abnormality of eosinophils (HP:0001879)	2.03956462
56	Sclerocornea (HP:0000647)	2.03771518
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.02825280
58	Central scotoma (HP:0000603)	2.01774707
59	Congenital primary aphakia (HP:0007707)	2.01377449
60	Furrowed tongue (HP:0000221)	2.00875157
61	Large for gestational age (HP:0001520)	1.99664477
62	Gait imbalance (HP:0002141)	1.99645611
63	T lymphocytopenia (HP:0005403)	1.99485509
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98775082
65	Absent/shortened dynein arms (HP:0200106)	1.98775082
66	Prostate neoplasm (HP:0100787)	1.97720519
67	Constricted visual fields (HP:0001133)	1.97519035
68	Dialeptic seizures (HP:0011146)	1.97472943
69	Ketoacidosis (HP:0001993)	1.93818549
70	Chronic diarrhea (HP:0002028)	1.89590581
71	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.89455344
72	Broad-based gait (HP:0002136)	1.88708926
73	Hypoplasia of the fovea (HP:0007750)	1.87892309
74	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87892309
75	Abnormality of T cells (HP:0002843)	1.87391741
76	Autoimmune hemolytic anemia (HP:0001890)	1.85702690
77	Focal seizures (HP:0007359)	1.84954909
78	Decreased circulating renin level (HP:0003351)	1.83574743
79	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.82977119
80	Widely spaced teeth (HP:0000687)	1.82673901
81	Postaxial foot polydactyly (HP:0001830)	1.82411334
82	Intestinal atresia (HP:0011100)	1.81990393
83	Abnormal protein glycosylation (HP:0012346)	1.81769840
84	Abnormal glycosylation (HP:0012345)	1.81769840
85	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.81769840
86	Abnormal protein N-linked glycosylation (HP:0012347)	1.81769840
87	Panhypogammaglobulinemia (HP:0003139)	1.81418056
88	Type II lissencephaly (HP:0007260)	1.81348144
89	Abnormality of the prostate (HP:0008775)	1.81301031
90	Abnormal albumin level (HP:0012116)	1.81133617
91	Hypoalbuminemia (HP:0003073)	1.81133617
92	Generalized hypopigmentation of hair (HP:0011358)	1.80178122
93	Nephrogenic diabetes insipidus (HP:0009806)	1.78863633
94	Retinitis pigmentosa (HP:0000510)	1.76031791
95	Polyuria (HP:0000103)	1.75255646
96	Absence seizures (HP:0002121)	1.75135451
97	Anencephaly (HP:0002323)	1.74823538
98	Facial diplegia (HP:0001349)	1.74723459
99	Albinism (HP:0001022)	1.73186019
100	Male pseudohermaphroditism (HP:0000037)	1.73092530

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.05993817
2	ACVR1B	3.17542497
3	BMPR1B	3.04697807
4	TXK	2.80766822
5	ADRBK2	2.72405527
6	TAOK3	2.58779535
7	MAP4K2	2.58507739
8	NUAK1	2.54275359
9	GRK1	2.38532064
10	ZAK	2.35528809
11	INSRR	2.25965231
12	PINK1	2.00682229
13	EIF2AK3	1.59956722
14	MAPK13	1.53075503
15	BCKDK	1.48664567
16	WNK3	1.42485518
17	AKT3	1.34050803
18	OXSR1	1.32633386
19	TEC	1.28332897
20	TNK2	1.28184455
21	MAP3K4	1.26399816
22	MKNK2	1.24276350
23	TRIM28	1.12289091
24	IKBKB	1.09884595
25	STK38L	1.08474891
26	CASK	1.07319531
27	MST4	1.02662538
28	BRSK2	1.01082427
29	MAP4K1	0.98225783
30	TLK1	0.95227443
31	CDK19	0.94402370
32	NLK	0.93903789
33	PIK3CG	0.93385689
34	MARK3	0.92446135
35	KIT	0.91964987
36	ITK	0.89600775
37	IKBKE	0.85972004
38	DAPK2	0.85895876
39	ADRBK1	0.85866783
40	TNIK	0.85512438
41	PTK2B	0.80467768
42	CSNK1A1L	0.80027695
43	PAK3	0.78795520
44	NTRK3	0.78699814
45	PRKCE	0.78367362
46	TGFBR1	0.77270759
47	PRKCQ	0.75118372
48	IRAK1	0.73730362
49	MUSK	0.73323316
50	SYK	0.72737515
51	MAPKAPK3	0.71425565
52	KDR	0.70602063
53	CAMKK2	0.68432079
54	EPHA3	0.68155161
55	CSNK1G1	0.66639345
56	FER	0.65029364
57	MELK	0.64589035
58	STK3	0.62481299
59	CSNK1G2	0.62046209
60	CSNK1G3	0.61359412
61	BCR	0.61209670
62	MAP2K7	0.59880190
63	ERBB3	0.58587666
64	MAP3K7	0.58268083
65	LATS1	0.55451168
66	VRK1	0.55030920
67	TRPM7	0.52754925
68	CHUK	0.52670121
69	LYN	0.52539538
70	BTK	0.51795333
71	SGK2	0.51275503
72	GRK6	0.49885763
73	FES	0.49770002
74	OBSCN	0.49258889
75	PIK3CA	0.48704624
76	STK39	0.47650128
77	LCK	0.47274377
78	BMPR2	0.47076053
79	BLK	0.46035224
80	GRK7	0.45955684
81	PLK2	0.45805145
82	PKN1	0.45476853
83	PRKAA2	0.45459377
84	MAP2K6	0.43167329
85	PRKCG	0.42612617
86	TIE1	0.39305969
87	RPS6KA5	0.38978227
88	MAPKAPK5	0.36334528
89	ABL1	0.36287413
90	CSNK1A1	0.35209228
91	CAMK2A	0.34829182
92	IGF1R	0.33592832
93	JAK1	0.32042823
94	MATK	0.31765349
95	PIM1	0.31737316
96	FGFR2	0.31426505
97	CSNK1D	0.30467818
98	CDK3	0.30466670
99	DYRK2	0.28604609
100	MKNK1	0.28476857

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.70400224
2	Primary immunodeficiency_Homo sapiens_hsa05340	2.70075209
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27350733
4	Butanoate metabolism_Homo sapiens_hsa00650	2.27152286
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.20783672
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.16950237
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.08563528
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00077798
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.99796011
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98949646
11	Allograft rejection_Homo sapiens_hsa05330	1.97586767
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.94963996
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.91684199
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89921367
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.83582562
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.82002514
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81630449
18	Asthma_Homo sapiens_hsa05310	1.75408194
19	Homologous recombination_Homo sapiens_hsa03440	1.74414261
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.67812296
21	Nicotine addiction_Homo sapiens_hsa05033	1.63155522
22	ABC transporters_Homo sapiens_hsa02010	1.60169698
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55659845
24	Olfactory transduction_Homo sapiens_hsa04740	1.54838171
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.53406023
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.52406908
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.47118089
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.41297421
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35701582
30	Taste transduction_Homo sapiens_hsa04742	1.35174798
31	Caffeine metabolism_Homo sapiens_hsa00232	1.33406141
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32571360
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31991003
34	Propanoate metabolism_Homo sapiens_hsa00640	1.27758221
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.26867762
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20357958
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.13814350
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13348010
39	Retinol metabolism_Homo sapiens_hsa00830	1.06404733
40	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.06081096
41	RNA polymerase_Homo sapiens_hsa03020	1.05976330
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.04861799
43	Peroxisome_Homo sapiens_hsa04146	1.04631055
44	Basal transcription factors_Homo sapiens_hsa03022	1.04181347
45	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02644742
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.01236037
47	Morphine addiction_Homo sapiens_hsa05032	0.98260350
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.95974754
49	Protein export_Homo sapiens_hsa03060	0.94683891
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92044304
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89744435
52	Circadian rhythm_Homo sapiens_hsa04710	0.89064743
53	Regulation of autophagy_Homo sapiens_hsa04140	0.88414275
54	Salivary secretion_Homo sapiens_hsa04970	0.86844129
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85248663
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84781916
57	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82784243
58	Circadian entrainment_Homo sapiens_hsa04713	0.81910814
59	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.81723123
60	Serotonergic synapse_Homo sapiens_hsa04726	0.80188546
61	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.79811986
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79763983
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78852415
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.78560420
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78127193
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.78022233
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77096630
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74893850
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.70383853
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65624711
71	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.64270628
72	RNA degradation_Homo sapiens_hsa03018	0.63685024
73	GABAergic synapse_Homo sapiens_hsa04727	0.63613673
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63339865
75	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62336642
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.60830486
77	Insulin secretion_Homo sapiens_hsa04911	0.59733361
78	Renin secretion_Homo sapiens_hsa04924	0.58611711
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55693190
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52473025
81	Measles_Homo sapiens_hsa05162	0.51626160
82	Purine metabolism_Homo sapiens_hsa00230	0.51085463
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50284532
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49561616
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47393020
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45570793
87	One carbon pool by folate_Homo sapiens_hsa00670	0.45054043
88	Herpes simplex infection_Homo sapiens_hsa05168	0.44766954
89	Mineral absorption_Homo sapiens_hsa04978	0.42996002
90	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.42839156
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42278412
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.41076980
93	TNF signaling pathway_Homo sapiens_hsa04668	0.40678881
94	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39368110
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35931724
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.35855426
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35854219
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33955230
99	Pancreatic secretion_Homo sapiens_hsa04972	0.31812902
100	Long-term depression_Homo sapiens_hsa04730	0.31795764

HLA-L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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