HLA-U

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.36750353
2cytidine deamination (GO:0009972)5.94948266
3cytidine metabolic process (GO:0046087)5.94948266
4cytidine catabolic process (GO:0006216)5.94948266
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.45955240
6T cell migration (GO:0072678)5.28841054
7positive regulation of gamma-delta T cell activation (GO:0046645)5.14852357
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.11485047
9regulation of T cell tolerance induction (GO:0002664)5.06932241
10cellular response to interleukin-15 (GO:0071350)4.96994537
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.90080546
12positive regulation of tolerance induction (GO:0002645)4.85373845
13negative T cell selection (GO:0043383)4.83781957
14positive thymic T cell selection (GO:0045059)4.72061311
15positive T cell selection (GO:0043368)4.62000768
16positive regulation of T cell mediated cytotoxicity (GO:0001916)4.59647508
17regulation of alpha-beta T cell proliferation (GO:0046640)4.51690004
18positive regulation of B cell differentiation (GO:0045579)4.47502382
19regulation of tolerance induction (GO:0002643)4.41883395
20DNA deamination (GO:0045006)4.35354434
21regulation of activation of Janus kinase activity (GO:0010533)4.33121881
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29955533
23negative thymic T cell selection (GO:0045060)4.28730361
24negative regulation of cell killing (GO:0031342)4.28236633
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28236633
26Arp2/3 complex-mediated actin nucleation (GO:0034314)4.23306317
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.23258193
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21630618
29response to interleukin-15 (GO:0070672)4.20505243
30regulation of B cell differentiation (GO:0045577)4.17747348
31regulation of B cell receptor signaling pathway (GO:0050855)4.13471281
32regulation of T cell mediated cytotoxicity (GO:0001914)4.03903925
33sequestering of actin monomers (GO:0042989)4.01882176
34regulation of gamma-delta T cell differentiation (GO:0045586)4.01255047
35thymic T cell selection (GO:0045061)4.00817396
36antigen processing and presentation of endogenous antigen (GO:0019883)3.97777314
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93857127
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.76240273
39leukocyte aggregation (GO:0070486)3.76061296
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.66290990
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.66290990
42actin nucleation (GO:0045010)3.66203828
43T cell selection (GO:0045058)3.64716898
44regulation of gamma-delta T cell activation (GO:0046643)3.62417038
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61830838
46regulation of natural killer cell mediated immunity (GO:0002715)3.51616224
47regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51616224
48pyrimidine nucleoside catabolic process (GO:0046135)3.48780473
49purine nucleotide salvage (GO:0032261)3.48751768
50sulfur amino acid catabolic process (GO:0000098)3.48546362
51regulation of regulatory T cell differentiation (GO:0045589)3.43060066
52lymphocyte migration (GO:0072676)3.42381638
53negative regulation by host of viral transcription (GO:0043922)3.41541543
54lymphocyte chemotaxis (GO:0048247)3.40724300
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.40392092
56regulation of lymphocyte chemotaxis (GO:1901623)3.33605797
57cellular response to type I interferon (GO:0071357)3.31232487
58type I interferon signaling pathway (GO:0060337)3.31232487
59positive regulation of cell killing (GO:0031343)3.30488832
60purine deoxyribonucleotide catabolic process (GO:0009155)3.30484725
61response to type I interferon (GO:0034340)3.30006949
62positive regulation of lymphocyte migration (GO:2000403)3.25176196
63positive regulation of natural killer cell mediated immunity (GO:0002717)3.24383849
64regulation of plasminogen activation (GO:0010755)3.21358486
65T cell receptor signaling pathway (GO:0050852)3.15133687
66immunoglobulin mediated immune response (GO:0016064)3.14064161
67positive regulation of calcium-mediated signaling (GO:0050850)3.13647106
68negative regulation of calcium ion transport into cytosol (GO:0010523)3.10480497
69negative regulation of viral genome replication (GO:0045071)3.10297316
70regulation of T cell receptor signaling pathway (GO:0050856)3.05462938
71regulation of cell killing (GO:0031341)3.02596307
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.02174477
73granulocyte activation (GO:0036230)3.00129686
74positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99062828
75negative regulation of T cell apoptotic process (GO:0070233)2.96837350
76positive regulation of monocyte chemotaxis (GO:0090026)2.96717902
77positive regulation of T cell mediated immunity (GO:0002711)2.95665890
78response to interferon-beta (GO:0035456)2.94016180
79positive regulation of interleukin-8 secretion (GO:2000484)2.91818390
80neutrophil activation involved in immune response (GO:0002283)2.89746291
81regulation of antigen processing and presentation (GO:0002577)2.87682962
82antigen receptor-mediated signaling pathway (GO:0050851)2.86757030
83adenosine metabolic process (GO:0046085)2.86753628
84detection of bacterium (GO:0016045)2.86619358
85negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.84512240
86indole-containing compound catabolic process (GO:0042436)2.84152494
87indolalkylamine catabolic process (GO:0046218)2.84152494
88tryptophan catabolic process (GO:0006569)2.84152494
89base-excision repair, AP site formation (GO:0006285)2.84064929
90negative regulation of leukocyte mediated immunity (GO:0002704)2.81001985
91neutrophil activation (GO:0042119)2.80426823
92T cell costimulation (GO:0031295)2.79908635
93regulation of interleukin-2 biosynthetic process (GO:0045076)2.79750045
94tryptophan metabolic process (GO:0006568)2.76314318
95lymphocyte costimulation (GO:0031294)2.76039969
96positive regulation of interleukin-1 beta secretion (GO:0050718)2.74865671
97regulation of lymphocyte migration (GO:2000401)2.71279291
98negative regulation of lymphocyte mediated immunity (GO:0002707)2.70039973
99negative regulation of stress fiber assembly (GO:0051497)2.69159485
100cytolysis (GO:0019835)2.68863937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.78232914
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.68620808
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.80907343
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.25679072
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39781844
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.15884799
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.11917107
8MYB_26560356_Chip-Seq_TH2_Human3.08297503
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63910663
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57722475
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50339646
12RUNX_20019798_ChIP-Seq_JUKART_Human2.49770494
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49205539
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44602316
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40677046
16UTX_26944678_Chip-Seq_JUKART_Human2.29187230
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.18021108
18MYB_26560356_Chip-Seq_TH1_Human2.17784929
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17501433
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13012556
21MAF_26560356_Chip-Seq_TH1_Human2.12548608
22MAF_26560356_Chip-Seq_TH2_Human2.08409747
23SCL_19346495_ChIP-Seq_HPC-7_Human2.04205993
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96589538
25SPI1_23547873_ChIP-Seq_NB4_Human1.94153575
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92055195
27GATA3_27048872_Chip-Seq_THYMUS_Human1.84559332
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71903071
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70808434
30VDR_24763502_ChIP-Seq_THP-1_Human1.69075772
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60151614
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59871003
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59016819
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58277121
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56516455
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54825785
37GATA3_26560356_Chip-Seq_TH2_Human1.52045415
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51355313
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50586863
40VDR_21846776_ChIP-Seq_THP-1_Human1.49238097
41BCL6_27268052_Chip-Seq_Bcells_Human1.49029634
42SPI1_23127762_ChIP-Seq_K562_Human1.48788039
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47681911
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46523892
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.44801555
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41259699
47MYC_22102868_ChIP-Seq_BL_Human1.37690990
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37366844
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32401340
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.30986169
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29240544
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28017713
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27438495
54LXR_22292898_ChIP-Seq_THP-1_Human1.19512264
55BCOR_27268052_Chip-Seq_Bcells_Human1.18915976
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17104218
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16577094
58SA1_27219007_Chip-Seq_Bcells_Human1.14660378
59P68_20966046_ChIP-Seq_HELA_Human1.13221472
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11792493
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10523091
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08224800
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07103602
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.04480754
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01773753
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01595643
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01453775
68P300_27268052_Chip-Seq_Bcells_Human1.00371004
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00224293
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00084272
71TAF2_19829295_ChIP-Seq_ESCs_Human0.99954196
72VDR_22108803_ChIP-Seq_LS180_Human0.99647443
73NANOG_20526341_ChIP-Seq_ESCs_Human0.98092958
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96950120
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95224470
76CTCF_26484167_Chip-Seq_Bcells_Mouse0.95172862
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95037286
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94760544
79MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92799622
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92555366
81SPI1_20517297_ChIP-Seq_HL60_Human0.92367878
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90939511
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.90731494
84PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88886356
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.88649311
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87970578
87STAT1_20625510_ChIP-Seq_HELA_Human0.87154028
88E2F1_20622854_ChIP-Seq_HELA_Human0.86562233
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86256026
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85358396
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85331130
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84708950
93CTCF_20526341_ChIP-Seq_ESCs_Human0.84649488
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82587149
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82441832
96CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82082787
97FOXP3_21729870_ChIP-Seq_TREG_Human0.81113792
98NCOR_22424771_ChIP-Seq_293T_Human0.80763818
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80394334
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80327978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.29809406
2MP0001835_abnormal_antigen_presentation3.38597073
3MP0009785_altered_susceptibility_to3.30687407
4MP0003724_increased_susceptibility_to3.22374056
5MP0009333_abnormal_splenocyte_physiolog3.10609709
6MP0005025_abnormal_response_to2.85609588
7MP0003763_abnormal_thymus_physiology2.83369186
8MP0005670_abnormal_white_adipose2.82827323
9MP0005000_abnormal_immune_tolerance2.78286794
10MP0001800_abnormal_humoral_immune2.78243214
11MP0003436_decreased_susceptibility_to2.75957268
12MP0002148_abnormal_hypersensitivity_rea2.64550063
13MP0002723_abnormal_immune_serum2.57837265
14MP0003183_abnormal_peptide_metabolism2.50556199
15MP0002420_abnormal_adaptive_immunity2.46734192
16MP0001819_abnormal_immune_cell2.42640186
17MP0002419_abnormal_innate_immunity2.37248439
18MP0005360_urolithiasis2.33591689
19MP0006082_CNS_inflammation2.31337302
20MP0002452_abnormal_antigen_presenting2.21615999
21MP0005646_abnormal_pituitary_gland2.07457978
22MP0001790_abnormal_immune_system2.05960117
23MP0005387_immune_system_phenotype2.05960117
24MP0010155_abnormal_intestine_physiology2.04664601
25MP0002396_abnormal_hematopoietic_system1.96915479
26MP0000716_abnormal_immune_system1.94490813
27MP0002166_altered_tumor_susceptibility1.92798926
28MP0002398_abnormal_bone_marrow1.92348613
29MP0002405_respiratory_system_inflammati1.79904645
30MP0003866_abnormal_defecation1.79505563
31MP0008872_abnormal_physiological_respon1.78296251
32MP0002138_abnormal_hepatobiliary_system1.76645884
33MP0002933_joint_inflammation1.70684375
34MP0001845_abnormal_inflammatory_respons1.68864126
35MP0005464_abnormal_platelet_physiology1.66131658
36MP0002132_abnormal_respiratory_system1.65594490
37MP0000703_abnormal_thymus_morphology1.65243870
38MP0000685_abnormal_immune_system1.60620551
39MP0002722_abnormal_immune_system1.59171744
40MP0005257_abnormal_intraocular_pressure1.56083029
41MP0002736_abnormal_nociception_after1.55996281
42MP0008469_abnormal_protein_level1.55795725
43MP0001533_abnormal_skeleton_physiology1.48866121
44MP0002429_abnormal_blood_cell1.47887836
45MP0002277_abnormal_respiratory_mucosa1.47873130
46MP0000689_abnormal_spleen_morphology1.44944839
47MP0002006_tumorigenesis1.43654544
48MP0001968_abnormal_touch/_nociception1.43406664
49MP0003646_muscle_fatigue1.33224025
50MP0003075_altered_response_to1.31396090
51MP0003045_fibrosis1.29562810
52MP0001853_heart_inflammation1.27305811
53MP0004947_skin_inflammation1.24184577
54MP0009763_increased_sensitivity_to1.22888995
55MP0008995_early_reproductive_senescence1.22625075
56MP0003448_altered_tumor_morphology1.18446410
57MP0005166_decreased_susceptibility_to1.17302626
58MP0004185_abnormal_adipocyte_glucose1.15643473
59MP0005164_abnormal_response_to1.13924514
60MP0000604_amyloidosis1.07897703
61MP0001873_stomach_inflammation1.07576013
62MP0003191_abnormal_cellular_cholesterol0.99894907
63MP0001851_eye_inflammation0.96713069
64MP0009764_decreased_sensitivity_to0.96573041
65MP0004883_abnormal_blood_vessel0.95412157
66MP0003786_premature_aging0.94186906
67MP0000372_irregular_coat_pigmentation0.93277386
68MP0000858_altered_metastatic_potential0.92453026
69MP0009765_abnormal_xenobiotic_induced0.86095327
70MP0003252_abnormal_bile_duct0.84270920
71MP0003806_abnormal_nucleotide_metabolis0.82711841
72MP0002693_abnormal_pancreas_physiology0.82553086
73MP0005410_abnormal_fertilization0.82451741
74MP0002019_abnormal_tumor_incidence0.81136863
75MP0004130_abnormal_muscle_cell0.80440475
76MP0004381_abnormal_hair_follicle0.78270999
77MP0005319_abnormal_enzyme/_coenzyme0.77693076
78MP0001765_abnormal_ion_homeostasis0.77606418
79MP0008873_increased_physiological_sensi0.75254012
80MP0009643_abnormal_urine_homeostasis0.75064027
81MP0000465_gastrointestinal_hemorrhage0.73989905
82MP0002837_dystrophic_cardiac_calcinosis0.73842924
83MP0009697_abnormal_copulation0.72785689
84MP0002139_abnormal_hepatobiliary_system0.71437584
85MP0000249_abnormal_blood_vessel0.66305537
86MP0005390_skeleton_phenotype0.65756753
87MP0001661_extended_life_span0.65618398
88MP0005636_abnormal_mineral_homeostasis0.63942438
89MP0003638_abnormal_response/metabolism_0.63906624
90MP0005666_abnormal_adipose_tissue0.63884252
91MP0000678_abnormal_parathyroid_gland0.63537779
92MP0001905_abnormal_dopamine_level0.63536759
93MP0002877_abnormal_melanocyte_morpholog0.63235570
94MP0003279_aneurysm0.63228230
95MP0001542_abnormal_bone_strength0.62043911
96MP0005058_abnormal_lysosome_morphology0.61963895
97MP0002998_abnormal_bone_remodeling0.60448458
98MP0005075_abnormal_melanosome_morpholog0.58597692
99MP0006054_spinal_hemorrhage0.57182055
100MP0005332_abnormal_amino_acid0.56508192

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)5.30427557
2Abnormality of T cell number (HP:0011839)5.17801853
3Elevated erythrocyte sedimentation rate (HP:0003565)5.03715022
4T lymphocytopenia (HP:0005403)4.40591316
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.19935773
6Spontaneous hematomas (HP:0007420)4.16753643
7Granulocytopenia (HP:0001913)4.13612095
8Stomatitis (HP:0010280)4.13526996
9Increased IgM level (HP:0003496)4.12930629
10Stomach cancer (HP:0012126)4.12409767
11Gastrointestinal infarctions (HP:0005244)4.04909787
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.96135263
13Abnormality of alanine metabolism (HP:0010916)3.96135263
14Hyperalaninemia (HP:0003348)3.96135263
15Abnormality of eosinophils (HP:0001879)3.91948743
16Eosinophilia (HP:0001880)3.79363947
17Myositis (HP:0100614)3.76489113
18Autoimmune thrombocytopenia (HP:0001973)3.75291594
19Recurrent abscess formation (HP:0002722)3.52203579
20Chronic diarrhea (HP:0002028)3.51405763
21Abnormality of T cells (HP:0002843)3.47584807
22Constricted visual fields (HP:0001133)3.39945531
23Anorexia (HP:0002039)3.35919411
24Pulmonary embolism (HP:0002204)3.33074589
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.31507448
26Leukocytosis (HP:0001974)3.30436171
27Pustule (HP:0200039)3.27970007
28IgG deficiency (HP:0004315)3.13378422
29Encephalitis (HP:0002383)3.06442407
30Abnormality of B cell number (HP:0010975)3.03660427
31Meningitis (HP:0001287)2.97150405
32Hemoptysis (HP:0002105)2.93277450
33Hypergammaglobulinemia (HP:0010702)2.93004770
34Hypoproteinemia (HP:0003075)2.91894499
35Abnormality of the prostate (HP:0008775)2.90037045
36Recurrent bacterial skin infections (HP:0005406)2.86544946
37Vasculitis (HP:0002633)2.84840248
38Aplastic anemia (HP:0001915)2.84663746
39Mediastinal lymphadenopathy (HP:0100721)2.84084850
40Chest pain (HP:0100749)2.83120864
41Obstructive lung disease (HP:0006536)2.78147654
42Chronic obstructive pulmonary disease (HP:0006510)2.78147654
43Orchitis (HP:0100796)2.76784254
44Pigmentary retinal degeneration (HP:0001146)2.76634778
45Eczematoid dermatitis (HP:0000976)2.75169183
46Abnormality of macrophages (HP:0004311)2.74514754
47Recurrent fungal infections (HP:0002841)2.74095090
48Severe combined immunodeficiency (HP:0004430)2.71679277
49Retrobulbar optic neuritis (HP:0100654)2.70666778
50Optic neuritis (HP:0100653)2.70666778
51Panhypogammaglobulinemia (HP:0003139)2.64912702
52Chronic otitis media (HP:0000389)2.61806623
53Congenital stationary night blindness (HP:0007642)2.61801833
54Recurrent cutaneous fungal infections (HP:0011370)2.61032429
55Chronic mucocutaneous candidiasis (HP:0002728)2.61032429
56Urticaria (HP:0001025)2.56455408
57Arterial thrombosis (HP:0004420)2.53819730
58Gangrene (HP:0100758)2.48003733
59Abnormality of the fetal cardiovascular system (HP:0010948)2.45334606
60Abnormal umbilical cord blood vessels (HP:0011403)2.45334606
61Single umbilical artery (HP:0001195)2.45334606
62Recurrent skin infections (HP:0001581)2.43994054
63Petechiae (HP:0000967)2.31231174
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.26779330
65Thrombophlebitis (HP:0004418)2.24080307
66Abnormality of T cell physiology (HP:0011840)2.18941365
67Reduced antithrombin III activity (HP:0001976)2.17773914
68Congenital sensorineural hearing impairment (HP:0008527)2.16912450
69Esophageal varix (HP:0002040)2.16600444
70Epistaxis (HP:0000421)2.13005615
71Recurrent viral infections (HP:0004429)2.12398325
72Generalized aminoaciduria (HP:0002909)2.10693487
73Recurrent sinusitis (HP:0011108)2.08423743
74Methylmalonic acidemia (HP:0002912)2.07907675
75Gingival bleeding (HP:0000225)2.05340775
76Homocystinuria (HP:0002156)2.04075411
77Abnormality of homocysteine metabolism (HP:0010919)2.04075411
78Recurrent gram-negative bacterial infections (HP:0005420)2.01612455
79Alveolar cell carcinoma (HP:0006519)2.00574417
80Attenuation of retinal blood vessels (HP:0007843)1.99793610
81Pulmonary infiltrates (HP:0002113)1.99353591
82Hypochromic anemia (HP:0001931)1.96340901
83Conjugated hyperbilirubinemia (HP:0002908)1.95888758
84Thyroiditis (HP:0100646)1.95028909
85Combined immunodeficiency (HP:0005387)1.93959726
86Recurrent bronchitis (HP:0002837)1.92704375
87Lymphopenia (HP:0001888)1.89061179
88Agammaglobulinemia (HP:0004432)1.88766144
89Oligomenorrhea (HP:0000876)1.86143718
90Type I transferrin isoform profile (HP:0003642)1.85799240
91Increased intramyocellular lipid droplets (HP:0012240)1.83693812
92Joint swelling (HP:0001386)1.82223680
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.82067807
94Increased IgE level (HP:0003212)1.80235919
95Abolished electroretinogram (ERG) (HP:0000550)1.79928724
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79920191
97Peritonitis (HP:0002586)1.79664443
98IgM deficiency (HP:0002850)1.79315961
99Keratoconjunctivitis sicca (HP:0001097)1.78279500
100Abnormality of the pleura (HP:0002103)1.74285781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.01519162
2MAP4K14.21920856
3MAP2K33.53542105
4MAP3K33.48138862
5TXK3.47628439
6TESK23.41025737
7IRAK42.68872060
8JAK32.46710070
9ITK2.44479924
10PINK12.44011978
11GRK62.26900546
12FES2.06238292
13BTK1.96632613
14MAP3K111.92406829
15TNK21.81336477
16SYK1.76496962
17CSK1.72307624
18TAOK31.70847102
19TBK11.62846030
20ZAP701.60621928
21IKBKE1.58936202
22PASK1.53404246
23LCK1.50386347
24TEC1.49404226
25PRKCQ1.44592481
26IKBKB1.35738797
27CAMKK11.34671838
28TESK11.33834936
29ERN11.31744057
30VRK21.24883902
31BCKDK1.23258623
32JAK11.19664296
33FGR1.18559806
34TYK21.14799783
35LYN1.11586308
36MATK1.11075899
37EPHB11.08882111
38HCK1.08836180
39RIPK41.08627578
40TAOK11.06572059
41CAMKK21.03872103
42CDK90.99411021
43JAK20.94685512
44CSF1R0.91523923
45BLK0.89831952
46MAP2K60.85688684
47TAOK20.83566793
48RPS6KB20.83430539
49NME20.82813751
50ACVR1B0.78287290
51IRAK10.77870293
52GRK70.72380135
53FYN0.69950029
54TRPM70.68401657
55MARK30.64818809
56SIK10.63349782
57ADRBK20.60987763
58PIM10.59872876
59KIT0.58199091
60LMTK20.56664754
61NME10.53629559
62DAPK20.53402832
63PRKD20.53117484
64SGK30.52225533
65PRKCD0.51559263
66LIMK10.49302311
67MAP3K140.45038246
68SGK20.44512350
69SGK4940.44266237
70SGK2230.44266237
71PRKCH0.43886163
72STK240.41895519
73IGF1R0.40104858
74INSR0.39760554
75PTK60.38212734
76MAP3K70.37863959
77ADRBK10.37851608
78VRK10.37720777
79MAP3K10.37304721
80ERBB30.36037009
81NTRK10.35249193
82PDK10.35199884
83MAPK110.34493163
84FRK0.33692743
85HIPK20.33283169
86PTK2B0.33150722
87DAPK10.32276561
88PRKCA0.31930150
89MAP4K20.31660100
90MAPK150.31192351
91PIK3CG0.30917572
92MAPK30.30126018
93GRK10.29772385
94SCYL20.29587744
95MAP3K50.28125198
96ABL10.28021267
97PAK40.27455203
98CDK40.26892116
99IRAK20.25697021
100MAPK120.25204615

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.61602898
2Graft-versus-host disease_Homo sapiens_hsa053324.11027750
3Allograft rejection_Homo sapiens_hsa053303.96849922
4Autoimmune thyroid disease_Homo sapiens_hsa053203.70305084
5Antigen processing and presentation_Homo sapiens_hsa046123.33915078
6Type I diabetes mellitus_Homo sapiens_hsa049403.19434243
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.75427441
8Hematopoietic cell lineage_Homo sapiens_hsa046402.50102336
9T cell receptor signaling pathway_Homo sapiens_hsa046602.38049284
10Proteasome_Homo sapiens_hsa030502.06518194
11Staphylococcus aureus infection_Homo sapiens_hsa051502.05974286
12Leishmaniasis_Homo sapiens_hsa051402.05884295
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99992147
14Rheumatoid arthritis_Homo sapiens_hsa053231.97769710
15Measles_Homo sapiens_hsa051621.96111603
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.77844853
17Viral myocarditis_Homo sapiens_hsa054161.74926583
18Asthma_Homo sapiens_hsa053101.64951984
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61217196
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59393847
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.56543373
22Sulfur metabolism_Homo sapiens_hsa009201.50214210
23Osteoclast differentiation_Homo sapiens_hsa043801.46231734
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38365830
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37010466
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28077975
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26913364
28Nitrogen metabolism_Homo sapiens_hsa009101.25885912
29Herpes simplex infection_Homo sapiens_hsa051681.18968096
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18960314
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16349740
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15106472
33African trypanosomiasis_Homo sapiens_hsa051431.14837601
34Collecting duct acid secretion_Homo sapiens_hsa049661.10564368
35Salmonella infection_Homo sapiens_hsa051321.06368643
36Tuberculosis_Homo sapiens_hsa051521.05760169
37Retinol metabolism_Homo sapiens_hsa008301.04829098
38Influenza A_Homo sapiens_hsa051641.03718201
39Other glycan degradation_Homo sapiens_hsa005110.99377605
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97477027
41Chemical carcinogenesis_Homo sapiens_hsa052040.96984249
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96799259
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96388084
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95875446
45Chemokine signaling pathway_Homo sapiens_hsa040620.95606441
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.95038892
47TNF signaling pathway_Homo sapiens_hsa046680.94329400
48B cell receptor signaling pathway_Homo sapiens_hsa046620.92478315
49Malaria_Homo sapiens_hsa051440.89137933
50Caffeine metabolism_Homo sapiens_hsa002320.88994018
51Pertussis_Homo sapiens_hsa051330.87811780
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85925699
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84968948
54Shigellosis_Homo sapiens_hsa051310.84514952
55Oxidative phosphorylation_Homo sapiens_hsa001900.77410297
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.70112305
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.68094687
58Toxoplasmosis_Homo sapiens_hsa051450.65553162
59Complement and coagulation cascades_Homo sapiens_hsa046100.63741692
60Systemic lupus erythematosus_Homo sapiens_hsa053220.63309576
61One carbon pool by folate_Homo sapiens_hsa006700.62580016
62Arginine biosynthesis_Homo sapiens_hsa002200.60836184
63Apoptosis_Homo sapiens_hsa042100.57279005
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56177135
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55749309
66Phagosome_Homo sapiens_hsa041450.53271616
67Platelet activation_Homo sapiens_hsa046110.51741216
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49410239
69Arachidonic acid metabolism_Homo sapiens_hsa005900.48952304
70Peroxisome_Homo sapiens_hsa041460.48590278
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48516970
72Base excision repair_Homo sapiens_hsa034100.45767072
73Legionellosis_Homo sapiens_hsa051340.44755394
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.43681478
75HTLV-I infection_Homo sapiens_hsa051660.40350805
76Linoleic acid metabolism_Homo sapiens_hsa005910.39534520
77Fatty acid biosynthesis_Homo sapiens_hsa000610.39491142
78Regulation of autophagy_Homo sapiens_hsa041400.38790720
79Olfactory transduction_Homo sapiens_hsa047400.37490066
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37072139
81Vitamin digestion and absorption_Homo sapiens_hsa049770.36723286
82Endocytosis_Homo sapiens_hsa041440.36499911
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34676732
84Taste transduction_Homo sapiens_hsa047420.34255597
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28898560
86Tryptophan metabolism_Homo sapiens_hsa003800.26945478
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26218843
88Epstein-Barr virus infection_Homo sapiens_hsa051690.25522454
89Salivary secretion_Homo sapiens_hsa049700.25015390
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21658439
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.20402556
92Morphine addiction_Homo sapiens_hsa050320.17219634
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.15753934
94Renin secretion_Homo sapiens_hsa049240.15408230
95ABC transporters_Homo sapiens_hsa020100.15047119
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.14456690
97Parkinsons disease_Homo sapiens_hsa050120.13562543
98Phototransduction_Homo sapiens_hsa047440.12371401
99Phenylalanine metabolism_Homo sapiens_hsa003600.11441346
100Galactose metabolism_Homo sapiens_hsa000520.11370179

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