HLA-V

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.24974965
2acrosome reaction (GO:0007340)5.97364230
3regulation of female gonad development (GO:2000194)5.52500738
4regulation of translation, ncRNA-mediated (GO:0045974)5.27538115
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.27538115
6negative regulation of translation, ncRNA-mediated (GO:0040033)5.27538115
7regulation of sarcomere organization (GO:0060297)4.88582327
8response to pheromone (GO:0019236)4.86902667
9fusion of sperm to egg plasma membrane (GO:0007342)4.82245557
10protein polyglutamylation (GO:0018095)4.49943410
11calcium ion-dependent exocytosis (GO:0017156)4.42109426
12cilium or flagellum-dependent cell motility (GO:0001539)4.37737467
13cellular ketone body metabolic process (GO:0046950)4.37255417
14multicellular organism reproduction (GO:0032504)4.26095596
15behavioral response to nicotine (GO:0035095)4.12146064
16sperm capacitation (GO:0048240)4.09100544
17spermatid development (GO:0007286)4.03852636
18NAD biosynthetic process (GO:0009435)3.97628915
19establishment of protein localization to Golgi (GO:0072600)3.96727109
20microtubule depolymerization (GO:0007019)3.89308655
21ketone body metabolic process (GO:1902224)3.83667911
22musculoskeletal movement (GO:0050881)3.81581801
23multicellular organismal movement (GO:0050879)3.81581801
24monoubiquitinated protein deubiquitination (GO:0035520)3.79301852
25response to misfolded protein (GO:0051788)3.69124316
26plasma membrane fusion (GO:0045026)3.64918452
27protein K48-linked deubiquitination (GO:0071108)3.54767557
28peptidyl-threonine dephosphorylation (GO:0035970)3.54113734
29membrane depolarization during action potential (GO:0086010)3.53355028
30microtubule severing (GO:0051013)3.52735959
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52306024
32reproduction (GO:0000003)3.51860697
33single strand break repair (GO:0000012)3.51815363
34microtubule polymerization or depolymerization (GO:0031109)3.51165548
35axonemal dynein complex assembly (GO:0070286)3.43229486
36regulation of cilium movement (GO:0003352)3.39733018
37regulation of Rab GTPase activity (GO:0032313)3.37692874
38positive regulation of Rab GTPase activity (GO:0032851)3.37692874
39positive regulation of CREB transcription factor activity (GO:0032793)3.26241823
40tryptophan catabolic process (GO:0006569)3.25552480
41indole-containing compound catabolic process (GO:0042436)3.25552480
42indolalkylamine catabolic process (GO:0046218)3.25552480
43positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.24650312
44regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.24650312
45chromatin silencing (GO:0006342)3.20919741
46sperm-egg recognition (GO:0035036)3.19416516
47kynurenine metabolic process (GO:0070189)3.18212035
48phosphatidylethanolamine biosynthetic process (GO:0006646)3.18074472
49protein targeting to Golgi (GO:0000042)3.16478559
50regulation of transcription involved in cell fate commitment (GO:0060850)3.10543745
51detection of light stimulus involved in sensory perception (GO:0050962)3.06960303
52detection of light stimulus involved in visual perception (GO:0050908)3.06960303
53pre-miRNA processing (GO:0031054)3.05846523
54retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03709624
55motile cilium assembly (GO:0044458)3.03641243
56DNA packaging (GO:0006323)3.01391650
57endothelial cell chemotaxis (GO:0035767)3.00190078
58reflex (GO:0060004)2.99599375
59indolalkylamine metabolic process (GO:0006586)2.99304124
60spinal cord motor neuron differentiation (GO:0021522)2.98441198
61pyridine nucleotide biosynthetic process (GO:0019363)2.96265403
62nicotinamide nucleotide biosynthetic process (GO:0019359)2.96265403
63cilium movement (GO:0003341)2.96169389
64gamma-aminobutyric acid transport (GO:0015812)2.95177090
65primary amino compound metabolic process (GO:1901160)2.94758166
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94506085
67male gamete generation (GO:0048232)2.91869749
68spermatogenesis (GO:0007283)2.91843576
69phosphatidylethanolamine metabolic process (GO:0046337)2.91775689
70epithelial cilium movement (GO:0003351)2.90516096
71cellular response to pH (GO:0071467)2.87086318
72positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.85486383
73regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.85486383
74appendage development (GO:0048736)2.85167135
75limb development (GO:0060173)2.85167135
76spermatid nucleus differentiation (GO:0007289)2.84367615
77protein K63-linked deubiquitination (GO:0070536)2.84196722
78chromosome condensation (GO:0030261)2.77468495
79locomotory exploration behavior (GO:0035641)2.76515648
80interkinetic nuclear migration (GO:0022027)2.75592176
81cAMP catabolic process (GO:0006198)2.74572996
82negative regulation of systemic arterial blood pressure (GO:0003085)2.73625517
83negative regulation of inclusion body assembly (GO:0090084)2.73437174
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72618557
85regulation of gene silencing by RNA (GO:0060966)2.71962089
86regulation of posttranscriptional gene silencing (GO:0060147)2.71962089
87regulation of gene silencing by miRNA (GO:0060964)2.71962089
88nonmotile primary cilium assembly (GO:0035058)2.70102541
89gamete generation (GO:0007276)2.69912115
90positive regulation of action potential (GO:0045760)2.69445375
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69153456
92postsynaptic membrane organization (GO:0001941)2.68174711
93cell-cell recognition (GO:0009988)2.68038247
94histone H3-K4 trimethylation (GO:0080182)2.67475162
95alanine transport (GO:0032328)2.67114530
96cranial nerve morphogenesis (GO:0021602)2.66469182
97centriole replication (GO:0007099)2.65447986
98neuromuscular synaptic transmission (GO:0007274)2.64890200
99calcium ion import (GO:0070509)2.64348843
100histone H3-K9 methylation (GO:0051567)2.63897680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.59661403
2DROSHA_22980978_ChIP-Seq_HELA_Human2.95849704
3CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31620725
4VDR_22108803_ChIP-Seq_LS180_Human2.13444389
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10651599
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10031502
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04351509
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.04351509
9ZNF274_21170338_ChIP-Seq_K562_Hela1.99172138
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97963925
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94043853
12GBX2_23144817_ChIP-Seq_PC3_Human1.91832277
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91130557
14REST_21632747_ChIP-Seq_MESCs_Mouse1.84029972
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.83094443
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.82224889
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79641347
18AR_21572438_ChIP-Seq_LNCaP_Human1.79522674
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74686591
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.71651453
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.71486022
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68025936
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66760295
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59052762
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56076894
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.46284736
27STAT3_23295773_ChIP-Seq_U87_Human1.44404365
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43920567
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36392545
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36392545
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36381290
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35265698
33ER_23166858_ChIP-Seq_MCF-7_Human1.31980799
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.31861751
35SMAD4_21799915_ChIP-Seq_A2780_Human1.31574197
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31115605
37CBP_20019798_ChIP-Seq_JUKART_Human1.31115605
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29886046
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28280429
40AR_25329375_ChIP-Seq_VCAP_Human1.28016760
41TCF4_23295773_ChIP-Seq_U87_Human1.27101556
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25602573
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24184003
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23560993
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22911110
46P300_19829295_ChIP-Seq_ESCs_Human1.21819202
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21388416
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.20494908
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19810684
50SMAD3_21741376_ChIP-Seq_ESCs_Human1.19657172
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18753498
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17644582
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17585624
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17380542
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17125368
56TAF15_26573619_Chip-Seq_HEK293_Human1.16384273
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16238932
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.15557325
59CTCF_27219007_Chip-Seq_Bcells_Human1.14152044
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.13737158
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.13604062
62TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12291260
63OCT4_20526341_ChIP-Seq_ESCs_Human1.11677730
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.11151735
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10666420
66CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10503488
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.09806402
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09441029
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08848667
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.08792978
71RNF2_27304074_Chip-Seq_NSC_Mouse1.08045544
72ERA_21632823_ChIP-Seq_H3396_Human1.07724316
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07473194
74BCAT_22108803_ChIP-Seq_LS180_Human1.07081049
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07017691
76AHR_22903824_ChIP-Seq_MCF-7_Human1.06890993
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05427868
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04926874
79RUNX2_22187159_ChIP-Seq_PCA_Human1.04240745
80RXR_22108803_ChIP-Seq_LS180_Human1.03513253
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02703879
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02165666
83AR_19668381_ChIP-Seq_PC3_Human1.01490231
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00987554
85KDM2B_26808549_Chip-Seq_REH_Human1.00215209
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00019859
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99902500
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99361506
89OCT1_27270436_Chip-Seq_PROSTATE_Human0.97757528
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97315503
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.97037364
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.95950183
93FUS_26573619_Chip-Seq_HEK293_Human0.95372888
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94104155
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93856617
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92967745
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91290205
98MYC_19829295_ChIP-Seq_ESCs_Human0.90983580
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90934635
100NANOG_20526341_ChIP-Seq_ESCs_Human0.90046696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.90422664
2MP0005377_hearing/vestibular/ear_phenot3.73659444
3MP0003878_abnormal_ear_physiology3.73659444
4MP0005670_abnormal_white_adipose3.27136423
5MP0003646_muscle_fatigue2.76275715
6MP0002735_abnormal_chemical_nociception2.74246565
7MP0001501_abnormal_sleep_pattern2.64315151
8MP0006276_abnormal_autonomic_nervous2.44803872
9MP0009745_abnormal_behavioral_response2.36640697
10MP0002822_catalepsy2.35218121
11MP0001348_abnormal_lacrimal_gland2.32578578
12MP0003698_abnormal_male_reproductive2.28270836
13MP0009046_muscle_twitch2.17207678
14MP0001485_abnormal_pinna_reflex2.17184239
15MP0002733_abnormal_thermal_nociception2.12997909
16MP0001440_abnormal_grooming_behavior2.05696965
17MP0005423_abnormal_somatic_nervous1.99827536
18MP0003879_abnormal_hair_cell1.99483927
19MP0001486_abnormal_startle_reflex1.96425672
20MP0001968_abnormal_touch/_nociception1.95986772
21MP0004142_abnormal_muscle_tone1.94025542
22MP0000569_abnormal_digit_pigmentation1.87376174
23MP0001929_abnormal_gametogenesis1.82657614
24MP0001970_abnormal_pain_threshold1.82388745
25MP0005551_abnormal_eye_electrophysiolog1.81963479
26MP0002557_abnormal_social/conspecific_i1.81662453
27MP0002572_abnormal_emotion/affect_behav1.80216154
28MP0002734_abnormal_mechanical_nocicepti1.72814060
29MP0002067_abnormal_sensory_capabilities1.69801815
30MP0001905_abnormal_dopamine_level1.68363725
31MP0003635_abnormal_synaptic_transmissio1.67941372
32MP0002272_abnormal_nervous_system1.65529516
33MP0003195_calcinosis1.61765149
34MP0002064_seizures1.54272317
35MP0004145_abnormal_muscle_electrophysio1.53390806
36MP0005645_abnormal_hypothalamus_physiol1.46791220
37MP0002249_abnormal_larynx_morphology1.45412282
38MP0008961_abnormal_basal_metabolism1.43971885
39MP0002063_abnormal_learning/memory/cond1.38812228
40MP0001963_abnormal_hearing_physiology1.38429340
41MP0000026_abnormal_inner_ear1.38347518
42MP0000955_abnormal_spinal_cord1.36069107
43MP0006292_abnormal_olfactory_placode1.35539084
44MP0004859_abnormal_synaptic_plasticity1.34366227
45MP0003787_abnormal_imprinting1.30196288
46MP0004043_abnormal_pH_regulation1.27116551
47MP0002928_abnormal_bile_duct1.27064707
48MP0002653_abnormal_ependyma_morphology1.26460074
49MP0002638_abnormal_pupillary_reflex1.26347833
50MP0008872_abnormal_physiological_respon1.25951055
51MP0004742_abnormal_vestibular_system1.22730515
52MP0002234_abnormal_pharynx_morphology1.22679465
53MP0000678_abnormal_parathyroid_gland1.22576019
54MP0004885_abnormal_endolymph1.22043730
55MP0008569_lethality_at_weaning1.20622731
56MP0003283_abnormal_digestive_organ1.16474345
57MP0002161_abnormal_fertility/fecundity1.14876809
58MP0005646_abnormal_pituitary_gland1.13232067
59MP0001765_abnormal_ion_homeostasis1.11511982
60MP0009053_abnormal_anal_canal1.10220324
61MP0002210_abnormal_sex_determination1.09545345
62MP0002184_abnormal_innervation1.09258622
63MP0004130_abnormal_muscle_cell1.05861436
64MP0000778_abnormal_nervous_system1.05751770
65MP0002229_neurodegeneration1.05163935
66MP0000631_abnormal_neuroendocrine_gland1.04790683
67MP0000470_abnormal_stomach_morphology1.01865746
68MP0002882_abnormal_neuron_morphology0.98104944
69MP0002752_abnormal_somatic_nervous0.98015210
70MP0010386_abnormal_urinary_bladder0.97279452
71MP0003119_abnormal_digestive_system0.96600218
72MP0002736_abnormal_nociception_after0.96295558
73MP0004133_heterotaxia0.92846667
74MP0003880_abnormal_central_pattern0.92209003
75MP0003632_abnormal_nervous_system0.91997943
76MP0003136_yellow_coat_color0.89679511
77MP0003045_fibrosis0.89488759
78MP0000653_abnormal_sex_gland0.89376412
79MP0005167_abnormal_blood-brain_barrier0.85456656
80MP0000049_abnormal_middle_ear0.84366612
81MP0004085_abnormal_heartbeat0.84291976
82MP0005253_abnormal_eye_physiology0.82803665
83MP0003718_maternal_effect0.82638767
84MP0008877_abnormal_DNA_methylation0.82361440
85MP0001145_abnormal_male_reproductive0.80915026
86MP0000230_abnormal_systemic_arterial0.80610853
87MP0005448_abnormal_energy_balance0.80495802
88MP0005195_abnormal_posterior_eye0.80459955
89MP0009115_abnormal_fat_cell0.76841622
90MP0000534_abnormal_ureter_morphology0.76825280
91MP0003631_nervous_system_phenotype0.76623813
92MP0008995_early_reproductive_senescence0.74790576
93MP0001188_hyperpigmentation0.74197792
94MP0004924_abnormal_behavior0.72283856
95MP0005386_behavior/neurological_phenoty0.72283856
96MP0002152_abnormal_brain_morphology0.71291048
97MP0005310_abnormal_salivary_gland0.69217477
98MP0003942_abnormal_urinary_system0.69060153
99MP0002066_abnormal_motor_capabilities/c0.68808543
100MP0003861_abnormal_nervous_system0.68558524

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)7.57853986
2Progressive cerebellar ataxia (HP:0002073)5.97910875
3Diplopia (HP:0000651)4.08545353
4Abnormality of binocular vision (HP:0011514)4.08545353
5Severe visual impairment (HP:0001141)4.07012519
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.95700035
7Gaze-evoked nystagmus (HP:0000640)3.84591856
8Hypoplastic ischia (HP:0003175)3.83901136
9Attenuation of retinal blood vessels (HP:0007843)3.78777630
10Chronic hepatic failure (HP:0100626)3.77203329
11Hyperkalemia (HP:0002153)3.46788055
12Bony spicule pigmentary retinopathy (HP:0007737)3.46580580
13Abnormality of the ischium (HP:0003174)3.41604313
14Nephronophthisis (HP:0000090)3.35550551
15Hyperventilation (HP:0002883)3.31826890
16Congenital stationary night blindness (HP:0007642)3.28461228
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.21570844
18Absent/shortened dynein arms (HP:0200106)3.21570844
19Pancreatic cysts (HP:0001737)3.15106126
20Retinal dysplasia (HP:0007973)3.09125918
21Decreased circulating renin level (HP:0003351)2.98556651
22Postural instability (HP:0002172)2.98247285
23Decreased central vision (HP:0007663)2.94706919
24Dysmetric saccades (HP:0000641)2.93770947
25Abnormality of the renal medulla (HP:0100957)2.91318133
26Impaired smooth pursuit (HP:0007772)2.90561342
27Abnormality of the pubic bones (HP:0003172)2.88882722
28Protruding tongue (HP:0010808)2.85482822
29Pancreatic fibrosis (HP:0100732)2.81019704
30Sclerocornea (HP:0000647)2.74333416
31Molar tooth sign on MRI (HP:0002419)2.72906118
32Abnormality of midbrain morphology (HP:0002418)2.72906118
33True hermaphroditism (HP:0010459)2.72533353
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72371703
35Polydipsia (HP:0001959)2.69267605
36Abnormal drinking behavior (HP:0030082)2.69267605
37Abnormal ciliary motility (HP:0012262)2.67213632
38Bell-shaped thorax (HP:0001591)2.62838515
39Abnormal respiratory motile cilium morphology (HP:0005938)2.59061356
40Abnormal respiratory epithelium morphology (HP:0012253)2.59061356
41Cystic liver disease (HP:0006706)2.54927940
42Abnormality of macular pigmentation (HP:0008002)2.50259327
43Abnormal rod and cone electroretinograms (HP:0008323)2.49968590
44Clumsiness (HP:0002312)2.49155614
45Truncal obesity (HP:0001956)2.48693117
46Impulsivity (HP:0100710)2.32515997
47Congenital sensorineural hearing impairment (HP:0008527)2.26216968
48Tubulointerstitial nephritis (HP:0001970)2.25676205
49Abnormal respiratory motile cilium physiology (HP:0012261)2.24880541
50Abnormality of potassium homeostasis (HP:0011042)2.23718308
51Urinary bladder sphincter dysfunction (HP:0002839)2.20633746
52Abnormality of the diencephalon (HP:0010662)2.20282642
53Febrile seizures (HP:0002373)2.19864005
54Abnormality of the fingertips (HP:0001211)2.17167126
55Ectopic kidney (HP:0000086)2.15465498
56Polyuria (HP:0000103)2.14423738
57Tubular atrophy (HP:0000092)2.10749127
58Oligodactyly (hands) (HP:0001180)2.09335665
59Potter facies (HP:0002009)2.06975635
60Facial shape deformation (HP:0011334)2.06975635
61Renovascular hypertension (HP:0100817)2.05921483
62Abnormal urine output (HP:0012590)2.02535607
63Abolished electroretinogram (ERG) (HP:0000550)2.00392687
64Abnormality of ocular smooth pursuit (HP:0000617)1.99983695
65Stereotypic behavior (HP:0000733)1.97858826
66Epileptic encephalopathy (HP:0200134)1.97589279
67Narrow nasal bridge (HP:0000446)1.97077884
68Increased neuronal autofluorescent lipopigment (HP:0002074)1.93739402
69Cone-rod dystrophy (HP:0000548)1.90832303
70Abnormality of renin-angiotensin system (HP:0000847)1.90197424
71Anencephaly (HP:0002323)1.90072199
72Oligodontia (HP:0000677)1.89854946
73Patellar aplasia (HP:0006443)1.89767296
74Visual hallucinations (HP:0002367)1.89197595
75Abnormality of the renal cortex (HP:0011035)1.89048958
76Myokymia (HP:0002411)1.88266109
77Abnormality of the renal collecting system (HP:0004742)1.86874980
78Broad-based gait (HP:0002136)1.86494780
79Bulbous nose (HP:0000414)1.86433652
80Focal seizures (HP:0007359)1.85174789
81Congenital hepatic fibrosis (HP:0002612)1.83378254
82Abnormality of the aortic arch (HP:0012303)1.80902335
83Macular degeneration (HP:0000608)1.78264968
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78118392
85Chorioretinal atrophy (HP:0000533)1.77333707
86Cerebellar dysplasia (HP:0007033)1.77169076
87Pendular nystagmus (HP:0012043)1.74681735
88Lip pit (HP:0100267)1.73823929
89Aplasia/Hypoplasia of the patella (HP:0006498)1.72563112
90Abnormality of renal excretion (HP:0011036)1.72204949
91Type II lissencephaly (HP:0007260)1.72167348
92Hemiparesis (HP:0001269)1.72089129
93Amelogenesis imperfecta (HP:0000705)1.71587938
94Absence seizures (HP:0002121)1.69426873
95Duplicated collecting system (HP:0000081)1.69263415
96Highly arched eyebrow (HP:0002553)1.68923981
97Keratoconus (HP:0000563)1.67897187
98Increased corneal curvature (HP:0100692)1.67897187
99Inability to walk (HP:0002540)1.67253581
100Dialeptic seizures (HP:0011146)1.64849828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.77803196
2INSRR4.70777337
3SIK23.71605643
4CAMK1G2.59426517
5DDR22.44275722
6PLK42.39084240
7BMPR1B2.36614867
8ACVR1B2.29970772
9CAMK1D2.21698544
10CDK122.21578856
11PNCK2.08428468
12CASK1.93022378
13STK381.92275571
14MAPK151.80156503
15WNK41.64845281
16ADRBK21.64254288
17NTRK31.58667253
18ICK1.33478304
19AKT31.33349492
20WNK11.32195045
21PRKD31.28271669
22TRIB31.26931369
23STK38L1.26789424
24TLK11.26569254
25DAPK21.16706592
26GRK11.16095782
27MAPK131.15929940
28NEK21.14864560
29MAP4K21.11483554
30TYRO31.08269742
31ADRBK11.03305110
32MARK21.02052420
33TNK21.01790773
34CAMKK10.98371623
35SGK4940.97098896
36SGK2230.97098896
37RPS6KA60.94468086
38CAMK10.93013848
39ZAK0.92912394
40TAOK30.92066885
41PKN10.89638041
42SGK20.89042511
43PRKCH0.87955695
44MAP3K40.87906073
45NTRK20.86108641
46PRKCG0.83535482
47PTK2B0.83489289
48PRKCE0.81105358
49MARK10.80532361
50BRD40.80220987
51OXSR10.76071127
52CAMK40.75929836
53PRKAA20.75216691
54MAP3K70.75104856
55KIT0.73155933
56RPS6KA20.71672228
57TESK10.71620852
58PRKAA10.69925993
59STK390.67793956
60MTOR0.67517030
61SGK10.63846177
62PDK10.62539039
63WNK30.61672039
64PDPK10.61577659
65GRK70.58671278
66MST1R0.57498616
67PLK20.57088214
68STK110.56444269
69CHUK0.55016727
70MAP3K90.54039024
71PINK10.53338479
72MAP2K60.52407643
73TGFBR10.50863649
74RPS6KC10.50767420
75RPS6KL10.50767420
76PRKG10.49792522
77GSK3B0.48945520
78PIK3CG0.46619903
79MAPK80.44478314
80PRKCZ0.44115579
81RPS6KA10.42768948
82PRKD20.42538673
83MKNK20.41869739
84ERBB20.40949963
85CDK40.39508337
86NUAK10.38532668
87SGK30.38026783
88MAPK110.37101300
89TNIK0.36886141
90MARK30.35938053
91MAP2K20.35910505
92AKT10.35792547
93MAPK10.34697776
94CHEK20.33863570
95DYRK1B0.32406488
96PRKCA0.31388727
97RPS6KA30.30132373
98CDK30.29928462
99PRKACA0.29459438
100CDC42BPA0.28483490

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52930786
2Morphine addiction_Homo sapiens_hsa050322.79862188
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73429861
4Taste transduction_Homo sapiens_hsa047422.61178220
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31168457
6GABAergic synapse_Homo sapiens_hsa047272.26473299
7Butanoate metabolism_Homo sapiens_hsa006502.14931568
8Phototransduction_Homo sapiens_hsa047442.12921404
9Fatty acid biosynthesis_Homo sapiens_hsa000612.09762589
10Circadian entrainment_Homo sapiens_hsa047132.07578893
11Olfactory transduction_Homo sapiens_hsa047402.00357540
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96328816
13Glutamatergic synapse_Homo sapiens_hsa047241.95342071
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90420767
15Serotonergic synapse_Homo sapiens_hsa047261.82662825
16Cholinergic synapse_Homo sapiens_hsa047251.79681444
17Insulin secretion_Homo sapiens_hsa049111.76161741
18Lysine degradation_Homo sapiens_hsa003101.74874024
19Linoleic acid metabolism_Homo sapiens_hsa005911.73771577
20Type II diabetes mellitus_Homo sapiens_hsa049301.65599304
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54889537
22Calcium signaling pathway_Homo sapiens_hsa040201.54628146
23ABC transporters_Homo sapiens_hsa020101.52308234
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.44650945
25Gastric acid secretion_Homo sapiens_hsa049711.43444869
26Selenocompound metabolism_Homo sapiens_hsa004501.41678489
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.40615604
28Oxytocin signaling pathway_Homo sapiens_hsa049211.32607573
29Nitrogen metabolism_Homo sapiens_hsa009101.32594930
30Dorso-ventral axis formation_Homo sapiens_hsa043201.30001605
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28693538
32Tryptophan metabolism_Homo sapiens_hsa003801.25360045
33Salivary secretion_Homo sapiens_hsa049701.22929556
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22214064
35Cocaine addiction_Homo sapiens_hsa050301.16974834
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.14542591
37Dopaminergic synapse_Homo sapiens_hsa047281.14479215
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12027396
39cAMP signaling pathway_Homo sapiens_hsa040241.07056769
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05909659
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.95045963
42Ether lipid metabolism_Homo sapiens_hsa005650.92843735
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.91224584
44Glycerolipid metabolism_Homo sapiens_hsa005610.90731637
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.89137583
46Long-term depression_Homo sapiens_hsa047300.87650467
47Synaptic vesicle cycle_Homo sapiens_hsa047210.84931227
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84452194
49Retinol metabolism_Homo sapiens_hsa008300.83910415
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83749684
51Estrogen signaling pathway_Homo sapiens_hsa049150.83341738
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80990735
53Ovarian steroidogenesis_Homo sapiens_hsa049130.79821433
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77926099
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75549514
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75271785
57MAPK signaling pathway_Homo sapiens_hsa040100.74558953
58Renin secretion_Homo sapiens_hsa049240.72828962
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.69987588
60Notch signaling pathway_Homo sapiens_hsa043300.68870903
61Bile secretion_Homo sapiens_hsa049760.68693579
62Hedgehog signaling pathway_Homo sapiens_hsa043400.67104121
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66759269
64Caffeine metabolism_Homo sapiens_hsa002320.62227557
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59023964
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57223296
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56192145
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.56116458
69Arachidonic acid metabolism_Homo sapiens_hsa005900.55380929
70Chemical carcinogenesis_Homo sapiens_hsa052040.55159309
71Cardiac muscle contraction_Homo sapiens_hsa042600.53167137
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51321678
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50971319
74Amphetamine addiction_Homo sapiens_hsa050310.50653210
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49555621
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48082905
77Axon guidance_Homo sapiens_hsa043600.47739320
78Choline metabolism in cancer_Homo sapiens_hsa052310.45093078
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44349115
80Pancreatic secretion_Homo sapiens_hsa049720.44281444
81Platelet activation_Homo sapiens_hsa046110.42763874
82Protein digestion and absorption_Homo sapiens_hsa049740.41172304
83Inositol phosphate metabolism_Homo sapiens_hsa005620.39511029
84Graft-versus-host disease_Homo sapiens_hsa053320.38747170
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37837765
86Tight junction_Homo sapiens_hsa045300.37399135
87Ras signaling pathway_Homo sapiens_hsa040140.37213242
88VEGF signaling pathway_Homo sapiens_hsa043700.36709519
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36001608
90Basal cell carcinoma_Homo sapiens_hsa052170.34587511
91PPAR signaling pathway_Homo sapiens_hsa033200.34253003
92Histidine metabolism_Homo sapiens_hsa003400.33885845
93Type I diabetes mellitus_Homo sapiens_hsa049400.32647122
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32626695
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31511577
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31438079
97Fatty acid degradation_Homo sapiens_hsa000710.31327253
98Insulin resistance_Homo sapiens_hsa049310.30280283
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29232182
100Dilated cardiomyopathy_Homo sapiens_hsa054140.28239028

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