HLA-W

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.69906772
2antigen processing and presentation of endogenous antigen (GO:0019883)6.32442549
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.26925896
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.18985643
5negative regulation of cell killing (GO:0031342)5.30325929
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30325929
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.70764430
8positive regulation of T cell mediated cytotoxicity (GO:0001916)4.40310506
9immunoglobulin mediated immune response (GO:0016064)4.28995299
10positive regulation of gamma-delta T cell activation (GO:0046645)4.21486211
11regulation of memory T cell differentiation (GO:0043380)4.19722690
12germinal center formation (GO:0002467)4.16501375
13regulation of T cell mediated cytotoxicity (GO:0001914)4.12280876
14regulation of antigen processing and presentation (GO:0002577)4.04107885
15negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.03085240
16negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.00765529
17negative regulation of T-helper cell differentiation (GO:0045623)4.00765529
18positive regulation of antigen processing and presentation (GO:0002579)4.00682253
19neutrophil activation involved in immune response (GO:0002283)3.96781519
20antigen processing and presentation via MHC class Ib (GO:0002475)3.91543925
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.89840194
22regulation of B cell receptor signaling pathway (GO:0050855)3.88206935
23leukocyte aggregation (GO:0070486)3.83573113
24neutrophil activation (GO:0042119)3.82878309
25cytidine deamination (GO:0009972)3.79190057
26cytidine metabolic process (GO:0046087)3.79190057
27cytidine catabolic process (GO:0006216)3.79190057
28regulation of interferon-beta biosynthetic process (GO:0045357)3.77224770
29B cell mediated immunity (GO:0019724)3.71708899
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.69623685
31interferon-gamma-mediated signaling pathway (GO:0060333)3.66375538
32type I interferon signaling pathway (GO:0060337)3.66073592
33cellular response to type I interferon (GO:0071357)3.66073592
34response to type I interferon (GO:0034340)3.63406724
35regulation of regulatory T cell differentiation (GO:0045589)3.56433962
36positive regulation of T cell mediated immunity (GO:0002711)3.53036946
37negative regulation of interleukin-12 production (GO:0032695)3.46695368
38growth hormone receptor signaling pathway (GO:0060396)3.43424895
39response to interferon-beta (GO:0035456)3.42250974
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.37804971
41granulocyte activation (GO:0036230)3.32597800
42response to interleukin-15 (GO:0070672)3.31234949
43regulation of T-helper 1 cell differentiation (GO:0045625)3.30709783
44leukocyte migration involved in inflammatory response (GO:0002523)3.30434600
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.30360099
46DNA deamination (GO:0045006)3.29791029
47regulation of germinal center formation (GO:0002634)3.29135637
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.26963956
49modulation by symbiont of host immune response (GO:0052553)3.26963956
50positive regulation by symbiont of host defense response (GO:0052509)3.26963956
51modulation by symbiont of host defense response (GO:0052031)3.26963956
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26963956
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26963956
54regulation of natural killer cell mediated immunity (GO:0002715)3.25223239
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.25223239
56cellular response to interleukin-15 (GO:0071350)3.22599316
57positive regulation of interferon-alpha production (GO:0032727)3.22528194
58negative regulation of leukocyte mediated immunity (GO:0002704)3.21964316
59positive regulation of natural killer cell differentiation (GO:0032825)3.21720565
60regulation of alpha-beta T cell proliferation (GO:0046640)3.21391212
61pyrimidine ribonucleoside catabolic process (GO:0046133)3.21238762
62positive regulation of tolerance induction (GO:0002645)3.19136550
63regulation of T cell mediated immunity (GO:0002709)3.18788941
64positive regulation of cell killing (GO:0031343)3.18425607
65detection of bacterium (GO:0016045)3.17020440
66detection of other organism (GO:0098543)3.14982154
67mast cell activation (GO:0045576)3.13062208
68regulation of cell killing (GO:0031341)3.12291094
69regulation of T cell tolerance induction (GO:0002664)3.12049053
70regulation of gamma-delta T cell activation (GO:0046643)3.11712615
71positive regulation of interleukin-8 secretion (GO:2000484)3.11186999
72leukocyte degranulation (GO:0043299)3.09706915
73regulation of interferon-alpha production (GO:0032647)3.09021369
74positive regulation of interleukin-1 beta secretion (GO:0050718)3.07450324
75positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.05999760
76response to peptidoglycan (GO:0032494)3.05938528
77regulation of tolerance induction (GO:0002643)3.05152700
78positive regulation of T-helper 1 type immune response (GO:0002827)3.02847693
79positive regulation of adaptive immune response (GO:0002821)3.02753379
80cellular response to growth hormone stimulus (GO:0071378)3.02225623
81positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02045991
82regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.99143939
83regulation of hypersensitivity (GO:0002883)2.98093085
84tolerance induction (GO:0002507)2.98004922
85myeloid cell activation involved in immune response (GO:0002275)2.96894243
86negative thymic T cell selection (GO:0045060)2.96778521
87negative T cell selection (GO:0043383)2.95750192
88positive thymic T cell selection (GO:0045059)2.95563301
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93663594
90negative regulation of B cell mediated immunity (GO:0002713)2.92845892
91negative regulation of immunoglobulin mediated immune response (GO:0002890)2.92845892
92regulation of interleukin-1 beta secretion (GO:0050706)2.92529242
93negative regulation of alpha-beta T cell activation (GO:0046636)2.91936856
94regulation of T-helper 2 cell differentiation (GO:0045628)2.89801284
95positive regulation of B cell differentiation (GO:0045579)2.88786349
96regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88721632
97negative regulation of B cell apoptotic process (GO:0002903)2.88271858
98negative regulation of cytokine production involved in immune response (GO:0002719)2.87785655
99positive regulation of defense response to virus by host (GO:0002230)2.87564230
100regulation of mast cell activation (GO:0033003)2.86836356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.88528665
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.44212813
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.06630357
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99127836
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.93427456
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.78460675
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67120090
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72470546
9MYB_26560356_Chip-Seq_TH2_Human2.59222311
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.59103032
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57974939
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.48589621
13SPI1_23547873_ChIP-Seq_NB4_Human2.35674917
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34596158
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31441760
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28980990
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25790351
18RUNX_20019798_ChIP-Seq_JUKART_Human2.20110075
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18279273
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17889522
21SPI1_23127762_ChIP-Seq_K562_Human2.09401701
22LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.08189349
23GATA3_27048872_Chip-Seq_THYMUS_Human2.07431950
24GATA3_26560356_Chip-Seq_TH2_Human2.04549271
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.91769348
26MYB_26560356_Chip-Seq_TH1_Human1.89538052
27MAF_26560356_Chip-Seq_TH1_Human1.87866136
28CIITA_25753668_ChIP-Seq_RAJI_Human1.86235687
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.82597875
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81038843
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75533371
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67300041
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65980238
34SCL_19346495_ChIP-Seq_HPC-7_Human1.63464249
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60053870
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58973504
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55692085
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54250439
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54228425
40ZNF274_21170338_ChIP-Seq_K562_Hela1.53040127
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51867714
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47626719
43UTX_26944678_Chip-Seq_JUKART_Human1.47136285
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45654396
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40232087
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.38705694
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34964803
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33918998
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.32146371
50VDR_24763502_ChIP-Seq_THP-1_Human1.30421259
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29360306
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27279952
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26475099
54BCL6_27268052_Chip-Seq_Bcells_Human1.25713430
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25593448
56VDR_24787735_ChIP-Seq_THP-1_Human1.24555225
57GATA1_19941826_ChIP-Seq_K562_Human1.23388575
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20513000
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19442703
60BCOR_27268052_Chip-Seq_Bcells_Human1.18841548
61MAF_26560356_Chip-Seq_TH2_Human1.17016686
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12653792
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11498109
64STAT1_20625510_ChIP-Seq_HELA_Human1.09301196
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.08712456
66E2F1_20622854_ChIP-Seq_HELA_Human1.08533307
67P300_27268052_Chip-Seq_Bcells_Human1.07083140
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06943032
69VDR_23849224_ChIP-Seq_CD4+_Human1.05295010
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02840517
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00304150
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98672159
73ELF1_20517297_ChIP-Seq_JURKAT_Human0.98487302
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98281588
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96366603
76GATA3_26560356_Chip-Seq_TH1_Human0.96045964
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94917396
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94741703
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93749238
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93612723
81TAF2_19829295_ChIP-Seq_ESCs_Human0.93118875
82ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91562945
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91368557
84NANOG_20526341_ChIP-Seq_ESCs_Human0.91223018
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90360195
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89616833
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.89322998
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87280565
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86413177
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86287145
91TP53_22573176_ChIP-Seq_HFKS_Human0.85791225
92CEBPB_22108803_ChIP-Seq_LS180_Human0.85039271
93SPI1_20517297_ChIP-Seq_HL60_Human0.84870641
94PU_27001747_Chip-Seq_BMDM_Mouse0.84083248
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83665914
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83247817
97AR_20517297_ChIP-Seq_VCAP_Human0.82674320
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81796980
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81788653
100BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.80774403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.20614648
2MP0001835_abnormal_antigen_presentation4.45790397
3MP0002138_abnormal_hepatobiliary_system4.17388928
4MP0003436_decreased_susceptibility_to3.52464942
5MP0005671_abnormal_response_to3.30888842
6MP0000685_abnormal_immune_system3.03329574
7MP0009785_altered_susceptibility_to2.99141113
8MP0005000_abnormal_immune_tolerance2.93513498
9MP0002148_abnormal_hypersensitivity_rea2.88257762
10MP0001800_abnormal_humoral_immune2.83550275
11MP0005387_immune_system_phenotype2.76563423
12MP0001790_abnormal_immune_system2.76563423
13MP0003303_peritoneal_inflammation2.69587244
14MP0002723_abnormal_immune_serum2.57711231
15MP0005025_abnormal_response_to2.48956494
16MP0002419_abnormal_innate_immunity2.46910772
17MP0002452_abnormal_antigen_presenting2.39496198
18MP0005167_abnormal_blood-brain_barrier2.38769849
19MP0002420_abnormal_adaptive_immunity2.34451920
20MP0001819_abnormal_immune_cell2.32501256
21MP0006082_CNS_inflammation2.22753269
22MP0005464_abnormal_platelet_physiology2.20177614
23MP0002166_altered_tumor_susceptibility1.95915418
24MP0003300_gastrointestinal_ulcer1.94828156
25MP0010155_abnormal_intestine_physiology1.91173049
26MP0004947_skin_inflammation1.89474121
27MP0003763_abnormal_thymus_physiology1.87318886
28MP0001533_abnormal_skeleton_physiology1.85026143
29MP0009333_abnormal_splenocyte_physiolog1.84109581
30MP0002398_abnormal_bone_marrow1.81051518
31MP0001845_abnormal_inflammatory_respons1.80187185
32MP0004381_abnormal_hair_follicle1.78788413
33MP0000716_abnormal_immune_system1.77714168
34MP0000465_gastrointestinal_hemorrhage1.74934388
35MP0003866_abnormal_defecation1.73982251
36MP0002405_respiratory_system_inflammati1.71760370
37MP0009764_decreased_sensitivity_to1.70126581
38MP0001873_stomach_inflammation1.63853199
39MP0002006_tumorigenesis1.57588495
40MP0000689_abnormal_spleen_morphology1.57248051
41MP0002722_abnormal_immune_system1.48164257
42MP0005084_abnormal_gallbladder_morpholo1.43519416
43MP0002429_abnormal_blood_cell1.42949467
44MP0008469_abnormal_protein_level1.40775690
45MP0002277_abnormal_respiratory_mucosa1.37015447
46MP0005075_abnormal_melanosome_morpholog1.32102360
47MP0000703_abnormal_thymus_morphology1.26694653
48MP0003172_abnormal_lysosome_physiology1.19250211
49MP0003828_pulmonary_edema1.14295557
50MP0003045_fibrosis1.12021351
51MP0002132_abnormal_respiratory_system1.10929351
52MP0001986_abnormal_taste_sensitivity1.08471636
53MP0003646_muscle_fatigue1.03799127
54MP0008875_abnormal_xenobiotic_pharmacok1.02228198
55MP0003075_altered_response_to0.99818206
56MP0005310_abnormal_salivary_gland0.98656098
57MP0001853_heart_inflammation0.97829782
58MP0005083_abnormal_biliary_tract0.97508564
59MP0002254_reproductive_system_inflammat0.96485878
60MP0003195_calcinosis0.94698028
61MP0001663_abnormal_digestive_system0.94074285
62MP0004147_increased_porphyrin_level0.86360142
63MP0009763_increased_sensitivity_to0.84486720
64MP0008872_abnormal_physiological_respon0.84183050
65MP0002876_abnormal_thyroid_physiology0.82247567
66MP0008004_abnormal_stomach_pH0.82228877
67MP0004808_abnormal_hematopoietic_stem0.80585627
68MP0002933_joint_inflammation0.79502435
69MP0002396_abnormal_hematopoietic_system0.79414251
70MP0000858_altered_metastatic_potential0.79285189
71MP0001545_abnormal_hematopoietic_system0.78619288
72MP0005397_hematopoietic_system_phenotyp0.78619288
73MP0001851_eye_inflammation0.74837858
74MP0009278_abnormal_bone_marrow0.73825290
75MP0004510_myositis0.69373850
76MP0005166_decreased_susceptibility_to0.67170011
77MP0005535_abnormal_body_temperature0.66003346
78MP0009765_abnormal_xenobiotic_induced0.65412247
79MP0003806_abnormal_nucleotide_metabolis0.65199854
80MP0004043_abnormal_pH_regulation0.64361005
81MP0002998_abnormal_bone_remodeling0.64253655
82MP0005390_skeleton_phenotype0.63287789
83MP0005410_abnormal_fertilization0.62014838
84MP0001501_abnormal_sleep_pattern0.61761941
85MP0003448_altered_tumor_morphology0.60812272
86MP0000249_abnormal_blood_vessel0.58873507
87MP0001765_abnormal_ion_homeostasis0.58089283
88MP0000609_abnormal_liver_physiology0.56842212
89MP0000343_altered_response_to0.56689075
90MP0005360_urolithiasis0.56060253
91MP0002693_abnormal_pancreas_physiology0.54787288
92MP0000613_abnormal_salivary_gland0.54782350
93MP0005319_abnormal_enzyme/_coenzyme0.54471316
94MP0003183_abnormal_peptide_metabolism0.54391218
95MP0002019_abnormal_tumor_incidence0.53152612
96MP0000230_abnormal_systemic_arterial0.52833574
97MP0003795_abnormal_bone_structure0.51595721
98MP0005365_abnormal_bile_salt0.50775173
99MP0005164_abnormal_response_to0.49877077
100MP0001542_abnormal_bone_strength0.49664903

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)8.10636567
2Stomatitis (HP:0010280)5.34570426
3Myositis (HP:0100614)4.98925042
4Retrobulbar optic neuritis (HP:0100654)4.53234810
5Optic neuritis (HP:0100653)4.53234810
6Orchitis (HP:0100796)4.46060497
7Encephalitis (HP:0002383)4.39757170
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.34307759
9Mediastinal lymphadenopathy (HP:0100721)3.96964201
10Eczematoid dermatitis (HP:0000976)3.86625716
11Recurrent fungal infections (HP:0002841)3.71447716
12Chronic mucocutaneous candidiasis (HP:0002728)3.52605156
13Recurrent cutaneous fungal infections (HP:0011370)3.52605156
14Chronic otitis media (HP:0000389)3.51972549
15Meningitis (HP:0001287)3.41219153
16Increased IgM level (HP:0003496)3.35476116
17Keratoconjunctivitis sicca (HP:0001097)3.35074822
18Keratoconjunctivitis (HP:0001096)3.31731519
19IgG deficiency (HP:0004315)3.30965490
20Recurrent abscess formation (HP:0002722)3.29215911
21Panhypogammaglobulinemia (HP:0003139)3.23205486
22Pulmonary infiltrates (HP:0002113)3.17174758
23Recurrent bacterial skin infections (HP:0005406)3.16647970
24Abnormality of macrophages (HP:0004311)3.12456589
25Abnormality of T cell number (HP:0011839)3.11651014
26Recurrent bronchitis (HP:0002837)3.07597194
27Hypochromic microcytic anemia (HP:0004840)3.05418009
28Vasculitis (HP:0002633)3.05174177
29Pustule (HP:0200039)3.04326075
30Autoimmune hemolytic anemia (HP:0001890)3.03164718
31Abnormality of T cell physiology (HP:0011840)3.02408293
32Abnormality of T cells (HP:0002843)3.00660104
33Hypochromic anemia (HP:0001931)2.99539627
34Eosinophilia (HP:0001880)2.96375568
35Hypergammaglobulinemia (HP:0010702)2.95777525
363-Methylglutaconic aciduria (HP:0003535)2.94120932
37Prolonged bleeding time (HP:0003010)2.91331563
38Microcytic anemia (HP:0001935)2.90339038
39Recurrent gram-negative bacterial infections (HP:0005420)2.85346208
40Granulocytopenia (HP:0001913)2.85234553
41Gastrointestinal infarctions (HP:0005244)2.81950045
42Arterial thrombosis (HP:0004420)2.80676825
43Decreased central vision (HP:0007663)2.80637088
44T lymphocytopenia (HP:0005403)2.79530575
45Recurrent skin infections (HP:0001581)2.77758183
46Chest pain (HP:0100749)2.77132393
47Leukocytosis (HP:0001974)2.76678510
48Chronic sinusitis (HP:0011109)2.63837123
49Hemoptysis (HP:0002105)2.63508010
50Abnormality of eosinophils (HP:0001879)2.61536707
51Large eyes (HP:0001090)2.59870224
52Abnormality of the pleura (HP:0002103)2.59364616
53Hypoproteinemia (HP:0003075)2.57963736
54Prostate neoplasm (HP:0100787)2.55859266
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53719844
56Abnormality of alanine metabolism (HP:0010916)2.53719844
57Hyperalaninemia (HP:0003348)2.53719844
58Obstructive lung disease (HP:0006536)2.52032274
59Chronic obstructive pulmonary disease (HP:0006510)2.52032274
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.49107129
61Abnormality of the prostate (HP:0008775)2.48320892
62Autoimmune thrombocytopenia (HP:0001973)2.47727273
63Epistaxis (HP:0000421)2.46122193
64Petechiae (HP:0000967)2.45360663
65Urticaria (HP:0001025)2.39989761
66Agammaglobulinemia (HP:0004432)2.36692098
67Recurrent viral infections (HP:0004429)2.36003358
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35303532
69Increased IgE level (HP:0003212)2.34851112
70Spontaneous hematomas (HP:0007420)2.34648908
71Chronic diarrhea (HP:0002028)2.33709028
72Skin rash (HP:0000988)2.33219129
73Increased cerebral lipofuscin (HP:0011813)2.31841789
74Episodic fever (HP:0001954)2.28234727
75Abnormality of the peritoneum (HP:0002585)2.20584160
76Pulmonary embolism (HP:0002204)2.19772978
77Stomach cancer (HP:0012126)2.19338111
78Anorexia (HP:0002039)2.19227383
79Abnormality of transition element cation homeostasis (HP:0011030)2.18872063
80Gingival bleeding (HP:0000225)2.18257064
81Attenuation of retinal blood vessels (HP:0007843)2.16171272
82Nasal polyposis (HP:0100582)2.14408981
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14319769
84Abnormality of iron homeostasis (HP:0011031)2.13908150
85Increased serum ferritin (HP:0003281)2.07849002
86IgM deficiency (HP:0002850)2.07287875
87Joint swelling (HP:0001386)2.06938679
88Keratitis (HP:0000491)2.06612689
89Congenital stationary night blindness (HP:0007642)2.06281108
90Abnormality of the fingertips (HP:0001211)2.05377021
91Gangrene (HP:0100758)2.04514896
92Abnormality of B cell number (HP:0010975)2.01989116
93Severe combined immunodeficiency (HP:0004430)2.00873957
94Cone-rod dystrophy (HP:0000548)1.97896524
95Reduced subcutaneous adipose tissue (HP:0003758)1.94771853
96Arthralgia (HP:0002829)1.93881958
97Pulmonary fibrosis (HP:0002206)1.93807185
98Abolished electroretinogram (ERG) (HP:0000550)1.93489881
99Facial diplegia (HP:0001349)1.90014163
100Vertigo (HP:0002321)1.88485586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.73720520
2TAOK33.46088060
3MAP4K13.17205182
4TLK13.01708156
5TXK2.94012346
6TIE12.83463106
7FES2.58944066
8MAP3K142.52642898
9IRAK42.42368120
10IKBKB2.19027919
11TBK12.13158821
12IKBKE2.11096418
13GRK61.96901344
14KIT1.93242230
15IRAK11.90277205
16BTK1.79454350
17TEC1.74860831
18SYK1.73282850
19TNK21.73128674
20ZAK1.68539417
21EPHB11.65810844
22CSK1.63694291
23ZAP701.58074100
24DAPK21.54425447
25NUAK11.53742865
26BCKDK1.51055656
27FRK1.49289772
28EPHA31.49282465
29JAK31.48904006
30ITK1.42537799
31MAP3K131.42462384
32GRK11.39394241
33MAP2K31.38607664
34BLK1.31932169
35BMPR1B1.30971376
36SIK31.30383665
37ERN11.30243145
38TYK21.27448765
39HCK1.27301839
40LYN1.23693233
41ADRBK21.23506894
42MARK31.22807546
43SIK21.20356856
44CHUK1.11883050
45LCK1.03373360
46MAP3K111.03043944
47BMPR21.01805866
48JAK20.93592805
49TESK20.91241581
50CSF1R0.89240186
51PIK3CG0.87457419
52MATK0.87065550
53RPS6KA50.82159437
54JAK10.81848233
55MST40.81173870
56FER0.80408063
57PRKCQ0.78966439
58PTK2B0.78145241
59WNK40.74528883
60MAP3K50.71218772
61IRAK30.70958731
62SMG10.68884538
63IRAK20.68705522
64FGFR30.67799777
65FGR0.62674013
66MAP2K20.62313458
67MAP2K60.61832692
68MAPKAPK30.59913829
69NLK0.59211220
70PIM10.56598962
71MAP3K30.54627295
72PDK10.53902798
73CAMKK20.53600289
74MUSK0.52396493
75KDR0.51906284
76CDK190.49834675
77FGFR40.49825670
78CDK80.49536189
79CDK90.48732089
80VRK10.46337242
81MAP4K20.45846783
82PINK10.45223951
83ACVR1B0.45133603
84MAP3K60.42529607
85TGFBR20.42264722
86RAF10.41798414
87TAOK10.41422676
88MAPK110.38309712
89HIPK20.35552331
90VRK20.34178128
91CSNK1G30.33078767
92PRKCD0.33057336
93GRK50.32908438
94WNK10.32734727
95ARAF0.32081155
96MAP3K70.31238337
97FYN0.31147536
98OXSR10.30800501
99KSR20.27667304
100PTK60.27658246

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.11833192
2Graft-versus-host disease_Homo sapiens_hsa053324.09804618
3Autoimmune thyroid disease_Homo sapiens_hsa053203.74850763
4Type I diabetes mellitus_Homo sapiens_hsa049403.21194444
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.97227940
6Staphylococcus aureus infection_Homo sapiens_hsa051502.94284330
7Primary immunodeficiency_Homo sapiens_hsa053402.91065162
8Antigen processing and presentation_Homo sapiens_hsa046122.87003150
9Asthma_Homo sapiens_hsa053102.78712789
10Leishmaniasis_Homo sapiens_hsa051402.65215461
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63472211
12Systemic lupus erythematosus_Homo sapiens_hsa053222.57905924
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32353077
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20913647
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00850241
16Osteoclast differentiation_Homo sapiens_hsa043801.95164836
17Hematopoietic cell lineage_Homo sapiens_hsa046401.95094715
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.89041231
19Herpes simplex infection_Homo sapiens_hsa051681.77834762
20Rheumatoid arthritis_Homo sapiens_hsa053231.75701899
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.68556069
22Viral myocarditis_Homo sapiens_hsa054161.67322857
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64539562
24Tuberculosis_Homo sapiens_hsa051521.63351140
25Measles_Homo sapiens_hsa051621.61390732
26B cell receptor signaling pathway_Homo sapiens_hsa046621.40922359
27Legionellosis_Homo sapiens_hsa051341.40762818
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35917028
29Influenza A_Homo sapiens_hsa051641.35382694
30T cell receptor signaling pathway_Homo sapiens_hsa046601.30249542
31Viral carcinogenesis_Homo sapiens_hsa052031.27814439
32Toxoplasmosis_Homo sapiens_hsa051451.26430077
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23994366
34Malaria_Homo sapiens_hsa051441.17597382
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.16153460
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12771450
37Alcoholism_Homo sapiens_hsa050341.07672605
38TNF signaling pathway_Homo sapiens_hsa046681.04579924
39Phagosome_Homo sapiens_hsa041451.04366913
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98647941
41Chemokine signaling pathway_Homo sapiens_hsa040620.97932653
42Platelet activation_Homo sapiens_hsa046110.93447072
43Shigellosis_Homo sapiens_hsa051310.87677450
44Arachidonic acid metabolism_Homo sapiens_hsa005900.83719872
45African trypanosomiasis_Homo sapiens_hsa051430.83672779
46Linoleic acid metabolism_Homo sapiens_hsa005910.82692600
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81974540
48ABC transporters_Homo sapiens_hsa020100.79200441
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76902163
50Nitrogen metabolism_Homo sapiens_hsa009100.75544902
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75392386
52Pertussis_Homo sapiens_hsa051330.74735227
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73550019
54Hepatitis C_Homo sapiens_hsa051600.70951261
55Epstein-Barr virus infection_Homo sapiens_hsa051690.70812356
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67425621
57Acute myeloid leukemia_Homo sapiens_hsa052210.65115145
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63950614
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61798246
60Collecting duct acid secretion_Homo sapiens_hsa049660.58012312
61Hepatitis B_Homo sapiens_hsa051610.53888518
62Salmonella infection_Homo sapiens_hsa051320.50303795
63Apoptosis_Homo sapiens_hsa042100.49139046
64Prolactin signaling pathway_Homo sapiens_hsa049170.45750916
65Olfactory transduction_Homo sapiens_hsa047400.44011346
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.43159051
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.43081360
68Phototransduction_Homo sapiens_hsa047440.42845353
69Proteasome_Homo sapiens_hsa030500.42344622
70Other glycan degradation_Homo sapiens_hsa005110.38747041
71Lysosome_Homo sapiens_hsa041420.38697641
72Fatty acid elongation_Homo sapiens_hsa000620.38238541
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38092432
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.35715068
75Regulation of autophagy_Homo sapiens_hsa041400.33341864
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32477082
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31638848
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31602079
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30178776
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27770061
81HTLV-I infection_Homo sapiens_hsa051660.25167414
82Type II diabetes mellitus_Homo sapiens_hsa049300.21054535
83Ether lipid metabolism_Homo sapiens_hsa005650.19589689
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16059109
85Caffeine metabolism_Homo sapiens_hsa002320.14661304
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14625437
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14498067
88Peroxisome_Homo sapiens_hsa041460.14197754
89Serotonergic synapse_Homo sapiens_hsa047260.12580770
90Endocytosis_Homo sapiens_hsa041440.11574148
91Tryptophan metabolism_Homo sapiens_hsa003800.11012076
92VEGF signaling pathway_Homo sapiens_hsa043700.10739875
93MAPK signaling pathway_Homo sapiens_hsa040100.09114465
94Pancreatic cancer_Homo sapiens_hsa052120.08618391
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.08109979
96Insulin resistance_Homo sapiens_hsa049310.05776123
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.05759489
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.05719063
99Glycerolipid metabolism_Homo sapiens_hsa005610.05555650
100Non-small cell lung cancer_Homo sapiens_hsa052230.05388514

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