HLTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.24155514
2mitotic sister chromatid cohesion (GO:0007064)4.19675610
3nuclear pore organization (GO:0006999)4.00107369
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85630550
5synapsis (GO:0007129)3.84937809
6regulation of centriole replication (GO:0046599)3.63883109
7neutrophil activation involved in immune response (GO:0002283)3.61659802
8negative regulation of transcription by competitive promoter binding (GO:0010944)3.52710958
9resolution of meiotic recombination intermediates (GO:0000712)3.41004073
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39483058
11telomere maintenance via semi-conservative replication (GO:0032201)3.35302243
12sister chromatid segregation (GO:0000819)3.31973423
13double-strand break repair via nonhomologous end joining (GO:0006303)3.30026207
14non-recombinational repair (GO:0000726)3.30026207
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28311386
16response to peptidoglycan (GO:0032494)3.27125317
17positive regulation of chemokine secretion (GO:0090197)3.24385722
18DNA unwinding involved in DNA replication (GO:0006268)3.24194769
19telomere maintenance via recombination (GO:0000722)3.21950000
20establishment of integrated proviral latency (GO:0075713)3.21277170
21mast cell activation (GO:0045576)3.20204080
22mitotic sister chromatid segregation (GO:0000070)3.19385885
23regulation of chemokine secretion (GO:0090196)3.16270095
24meiotic chromosome segregation (GO:0045132)3.14260983
25ribosomal small subunit assembly (GO:0000028)3.13730390
26DNA double-strand break processing (GO:0000729)3.11781559
27respiratory burst (GO:0045730)3.11401053
28histone exchange (GO:0043486)3.03978622
29mitotic chromosome condensation (GO:0007076)3.01191115
30regulation of B cell receptor signaling pathway (GO:0050855)3.00481135
31protein localization to kinetochore (GO:0034501)3.00230905
32pore complex assembly (GO:0046931)2.98072264
33negative regulation of granulocyte differentiation (GO:0030853)2.96882288
34metaphase plate congression (GO:0051310)2.95171595
35regulation of centrosome cycle (GO:0046605)2.92498716
36sister chromatid cohesion (GO:0007062)2.91752590
37positive regulation of gamma-delta T cell activation (GO:0046645)2.91623639
38mitotic recombination (GO:0006312)2.90419820
39interferon-gamma production (GO:0032609)2.89570817
40regulation of centrosome duplication (GO:0010824)2.84967224
41chromosome organization involved in meiosis (GO:0070192)2.84178560
42cellular response to zinc ion (GO:0071294)2.81001964
43mitotic metaphase plate congression (GO:0007080)2.80752342
44DNA synthesis involved in DNA repair (GO:0000731)2.76048458
45negative regulation of DNA-dependent DNA replication (GO:2000104)2.75988967
46developmental pigmentation (GO:0048066)2.75524007
47replication fork processing (GO:0031297)2.74761998
48DNA replication-independent nucleosome assembly (GO:0006336)2.74442420
49DNA replication-independent nucleosome organization (GO:0034724)2.74442420
50centriole replication (GO:0007099)2.74419803
51neutrophil activation (GO:0042119)2.72568371
52protein localization to chromosome, centromeric region (GO:0071459)2.71779663
53DNA ligation (GO:0006266)2.71296176
54ribosomal large subunit biogenesis (GO:0042273)2.70525592
55DNA replication checkpoint (GO:0000076)2.69895194
56somatic hypermutation of immunoglobulin genes (GO:0016446)2.69216583
57somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69216583
58DNA strand elongation (GO:0022616)2.67606493
59negative regulation of phagocytosis (GO:0050765)2.65601153
60telomere maintenance via telomere lengthening (GO:0010833)2.65525771
61histone H2A acetylation (GO:0043968)2.65121798
62leukocyte aggregation (GO:0070486)2.64939678
63spindle checkpoint (GO:0031577)2.63902420
64signal peptide processing (GO:0006465)2.63819354
65purine nucleobase biosynthetic process (GO:0009113)2.60937667
66T cell migration (GO:0072678)2.60754390
67dendritic cell chemotaxis (GO:0002407)2.59996032
68centriole assembly (GO:0098534)2.59944596
69positive regulation of antigen processing and presentation (GO:0002579)2.59452743
70intra-S DNA damage checkpoint (GO:0031573)2.59081017
71microtubule depolymerization (GO:0007019)2.58548800
72DNA strand elongation involved in DNA replication (GO:0006271)2.58447885
73mitotic nuclear envelope disassembly (GO:0007077)2.56706173
74DNA replication-dependent nucleosome organization (GO:0034723)2.56541719
75DNA replication-dependent nucleosome assembly (GO:0006335)2.56541719
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56294293
77leukocyte degranulation (GO:0043299)2.55959701
78mitotic spindle organization (GO:0007052)2.55454430
79protein heterotetramerization (GO:0051290)2.54410788
80negative regulation of DNA recombination (GO:0045910)2.54289098
81neutrophil mediated immunity (GO:0002446)2.54071204
82regulation of chromosome segregation (GO:0051983)2.53970390
83regulation of DNA endoreduplication (GO:0032875)2.53870530
84mitotic spindle checkpoint (GO:0071174)2.53870300
85cotranslational protein targeting to membrane (GO:0006613)2.52706822
86dendritic cell migration (GO:0036336)2.51752011
87kinetochore assembly (GO:0051382)2.50113335
88protein K6-linked ubiquitination (GO:0085020)2.50059309
89ribosomal small subunit biogenesis (GO:0042274)2.49835493
90protein targeting to ER (GO:0045047)2.49048640
91pinocytosis (GO:0006907)2.48949107
92protein localization to chromosome (GO:0034502)2.48102008
93myeloid dendritic cell activation (GO:0001773)2.47477728
94regulation of antigen processing and presentation (GO:0002577)2.46976706
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46293457
96G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.46241405
97regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.45851425
98mast cell degranulation (GO:0043303)2.45834681
99mast cell activation involved in immune response (GO:0002279)2.45834681
100presynaptic membrane assembly (GO:0097105)2.44467481
101myeloid cell activation involved in immune response (GO:0002275)2.44352985
102regulation of sister chromatid cohesion (GO:0007063)2.44217095
103superoxide anion generation (GO:0042554)2.44215650
104negative regulation of chromosome segregation (GO:0051985)2.44056867
105regulation of sister chromatid segregation (GO:0033045)2.43675743
106regulation of mitotic sister chromatid separation (GO:0010965)2.43675743
107regulation of mitotic sister chromatid segregation (GO:0033047)2.43675743
108modulation of growth of symbiont involved in interaction with host (GO:0044144)2.43419645
109regulation of growth of symbiont in host (GO:0044126)2.43419645
110negative regulation of growth of symbiont in host (GO:0044130)2.43419645
111negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.43419645
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43282731
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.43282731
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43282731
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.43282731
116negative regulation of sister chromatid segregation (GO:0033046)2.43282731
117kinetochore organization (GO:0051383)2.43137198
118positive regulation by symbiont of host defense response (GO:0052509)2.42890406
119modulation by symbiont of host defense response (GO:0052031)2.42890406
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42890406
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42890406
122positive regulation by organism of defense response of other organism involved in symbiotic interact2.42890406
123modulation by symbiont of host immune response (GO:0052553)2.42890406
124viral transcription (GO:0019083)2.42086728
125DNA topological change (GO:0006265)2.41780827
126nucleobase biosynthetic process (GO:0046112)2.41144647
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.40813561
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.40813561
129regulation of translational fidelity (GO:0006450)2.40793151
130myeloid leukocyte mediated immunity (GO:0002444)2.40368589
131cellular response to interferon-beta (GO:0035458)2.39660659
132membrane disassembly (GO:0030397)2.39053101
133nuclear envelope disassembly (GO:0051081)2.39053101
134ATP-dependent chromatin remodeling (GO:0043044)2.37671117
135mitotic spindle assembly checkpoint (GO:0007094)2.37613845
136establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37124232
137microglial cell activation (GO:0001774)2.36781235
138reciprocal meiotic recombination (GO:0007131)2.36562019
139reciprocal DNA recombination (GO:0035825)2.36562019
140DNA deamination (GO:0045006)2.36176763
141granulocyte activation (GO:0036230)2.35962487
142postreplication repair (GO:0006301)2.35712014
143spindle assembly checkpoint (GO:0071173)2.35642157
144immunoglobulin mediated immune response (GO:0016064)2.35599818
145positive regulation of defense response to virus by host (GO:0002230)2.35451445
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.35366666
147tRNA aminoacylation for protein translation (GO:0006418)2.35289329
148telomere maintenance (GO:0000723)2.35010333
149DNA replication initiation (GO:0006270)2.34578335
150chromosome segregation (GO:0007059)2.34313595
151protein localization to endoplasmic reticulum (GO:0070972)2.33615229
152positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33501905
153tRNA aminoacylation (GO:0043039)2.33096679
154amino acid activation (GO:0043038)2.33096679
155regulation of pigment cell differentiation (GO:0050932)2.32856515
156ribosome assembly (GO:0042255)2.32560498
157negative regulation of B cell proliferation (GO:0030889)2.32285990
158cellular response to interleukin-15 (GO:0071350)2.31802271
159translational termination (GO:0006415)2.31391753
160telomere organization (GO:0032200)2.31291465
161telomere maintenance via telomerase (GO:0007004)2.30540739
162positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.30179095
163positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.30179095
164positive regulation of mitotic sister chromatid separation (GO:1901970)2.30179095
165B cell receptor signaling pathway (GO:0050853)2.29270373
166mannosylation (GO:0097502)2.28793744
167regulation of acyl-CoA biosynthetic process (GO:0050812)2.28667941
168detection of other organism (GO:0098543)2.28281116
169GPI anchor biosynthetic process (GO:0006506)2.27857352
170regulation of coenzyme metabolic process (GO:0051196)2.27656752
171regulation of cofactor metabolic process (GO:0051193)2.27656752
172translesion synthesis (GO:0019985)2.27407137
173mature B cell differentiation (GO:0002335)2.26833036
174regulation of T cell receptor signaling pathway (GO:0050856)2.26685082
175C-terminal protein lipidation (GO:0006501)2.26418410
176IMP biosynthetic process (GO:0006188)2.26053189
177negative regulation of myotube differentiation (GO:0010832)2.26021605
178establishment of chromosome localization (GO:0051303)2.25228956
179lymphoid progenitor cell differentiation (GO:0002320)2.23660119
180regulation of interleukin-6 biosynthetic process (GO:0045408)2.22715546
181RNA-dependent DNA replication (GO:0006278)2.22663008
182CENP-A containing nucleosome assembly (GO:0034080)2.22588167
183mesenchymal cell differentiation involved in kidney development (GO:0072161)2.21703158
184mesenchymal cell differentiation involved in renal system development (GO:2001012)2.21703158
185chromatin remodeling at centromere (GO:0031055)2.20556351
186positive T cell selection (GO:0043368)2.18640036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99280096
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88739777
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.21121282
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20902445
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.19603200
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.18759698
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.12654213
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.10834304
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65101137
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60820863
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57656420
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43553300
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35596688
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33874888
15AR_21909140_ChIP-Seq_LNCAP_Human2.30842266
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29725693
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24979693
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.20704865
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19820880
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19016196
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18039223
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17640925
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15965777
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11407168
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.06716824
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95079621
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94796351
28SPI1_23547873_ChIP-Seq_NB4_Human1.90510163
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90162369
30ELK1_19687146_ChIP-ChIP_HELA_Human1.88781353
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85843456
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.82289987
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.79344126
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76711662
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75766431
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.75698012
37TAF15_26573619_Chip-Seq_HEK293_Human1.75272145
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.73791783
39GBX2_23144817_ChIP-Seq_PC3_Human1.72030703
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70544289
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68107548
42ZNF274_21170338_ChIP-Seq_K562_Hela1.67404943
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67081469
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65914365
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.65087264
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63688937
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62701856
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.61618063
49VDR_23849224_ChIP-Seq_CD4+_Human1.61034959
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60374355
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59380758
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58082240
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56184415
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55581467
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55461353
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55052861
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54688410
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53931049
59VDR_22108803_ChIP-Seq_LS180_Human1.47914840
60* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47912454
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47827454
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47821129
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47521087
64MYB_26560356_Chip-Seq_TH2_Human1.45936093
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.45606907
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.44616570
67* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44184508
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42060339
69* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41650758
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41165164
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40901285
72RUNX_20019798_ChIP-Seq_JUKART_Human1.39892777
73IRF1_19129219_ChIP-ChIP_H3396_Human1.37136225
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36419267
75FOXP3_21729870_ChIP-Seq_TREG_Human1.36225534
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36064473
77IGF1R_20145208_ChIP-Seq_DFB_Human1.34923174
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33790531
79MYC_18940864_ChIP-ChIP_HL60_Human1.33574549
80DCP1A_22483619_ChIP-Seq_HELA_Human1.33060047
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31334044
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.31328549
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30639722
84P300_18555785_Chip-Seq_ESCs_Mouse1.30278403
85PU_27001747_Chip-Seq_BMDM_Mouse1.30012675
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29750155
87* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29040628
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29008682
89P300_19829295_ChIP-Seq_ESCs_Human1.28538525
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28450924
91MYC_18555785_ChIP-Seq_MESCs_Mouse1.28195356
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25347270
93TTF2_22483619_ChIP-Seq_HELA_Human1.24547213
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.24304374
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23695476
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23377357
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20912016
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.20911581
99RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20495260
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19739761
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19537099
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19418570
103* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17282934
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17212296
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17173204
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17151003
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.17146883
108P53_22387025_ChIP-Seq_ESCs_Mouse1.17013200
109SCL_19346495_ChIP-Seq_HPC-7_Human1.16645556
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.15925614
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15689694
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.14658739
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.14050473
114MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14023256
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13295638
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12494716
117RNF2_27304074_Chip-Seq_NSC_Mouse1.12106494
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10205718
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09601299
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.09401563
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.09282362
122MYB_26560356_Chip-Seq_TH1_Human1.08851066
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08583335
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08578242
125PU1_27457419_Chip-Seq_LIVER_Mouse1.07440184
126NANOG_16153702_ChIP-ChIP_HESCs_Human1.06869070
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06719247
128* SOX9_26525672_Chip-Seq_HEART_Mouse1.06701409
129GATA1_22025678_ChIP-Seq_K562_Human1.06556099
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06155077
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05431075
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05428932
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05263160
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05242548
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05242548
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05242548
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.05212380
138FOXM1_23109430_ChIP-Seq_U2OS_Human1.05208606
139SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03739737
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03030610
141KLF4_18555785_Chip-Seq_ESCs_Mouse1.02828454
142XRN2_22483619_ChIP-Seq_HELA_Human1.01903140
143MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01828606
144MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01815367
145GABP_19822575_ChIP-Seq_HepG2_Human1.01213683
146CTCF_18555785_Chip-Seq_ESCs_Mouse1.00527979
147EWS_26573619_Chip-Seq_HEK293_Human0.99714055
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.99396517
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.99219322
150* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99211821
151SMAD4_21799915_ChIP-Seq_A2780_Human0.98770014
152* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98709579
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.97670244
154FUS_26573619_Chip-Seq_HEK293_Human0.97594187
155ER_23166858_ChIP-Seq_MCF-7_Human0.97511730
156LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96023181
157STAT3_23295773_ChIP-Seq_U87_Human0.95541056
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95336040
159CBX2_27304074_Chip-Seq_ESCs_Mouse0.93620083
160TP63_19390658_ChIP-ChIP_HaCaT_Human0.92941203
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.92447369
162MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92116365
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.90980991
164* SRF_21415370_ChIP-Seq_HL-1_Mouse0.90445553
165KDM5A_27292631_Chip-Seq_BREAST_Human0.90223794
166TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89593126
167ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88938071
168* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88030563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.59609491
2MP0001835_abnormal_antigen_presentation3.45996558
3MP0005174_abnormal_tail_pigmentation3.36713423
4MP0003724_increased_susceptibility_to3.27329660
5MP0009379_abnormal_foot_pigmentation3.07781695
6MP0000015_abnormal_ear_pigmentation3.04783713
7MP0005409_darkened_coat_color2.94074040
8MP0001188_hyperpigmentation2.71474353
9MP0004381_abnormal_hair_follicle2.68558890
10MP0005671_abnormal_response_to2.65853489
11MP0003763_abnormal_thymus_physiology2.42339426
12MP0001986_abnormal_taste_sensitivity2.41388112
13MP0002148_abnormal_hypersensitivity_rea2.39494774
14MP0008057_abnormal_DNA_replication2.36817774
15MP0002277_abnormal_respiratory_mucosa2.28430833
16MP0002009_preneoplasia2.21438064
17MP0005000_abnormal_immune_tolerance2.21296880
18MP0009785_altered_susceptibility_to2.14462519
19MP0001800_abnormal_humoral_immune2.06294903
20MP0004957_abnormal_blastocyst_morpholog2.05935934
21MP0006292_abnormal_olfactory_placode2.05067212
22MP0002095_abnormal_skin_pigmentation2.04262496
23MP0003890_abnormal_embryonic-extraembry2.02825568
24MP0002419_abnormal_innate_immunity2.00731405
25MP0005075_abnormal_melanosome_morpholog1.99119893
26MP0002452_abnormal_antigen_presenting1.95571080
27MP0003121_genomic_imprinting1.93566634
28MP0002723_abnormal_immune_serum1.92568752
29MP0002420_abnormal_adaptive_immunity1.91827266
30MP0002166_altered_tumor_susceptibility1.90498453
31MP0003436_decreased_susceptibility_to1.89488133
32MP0001790_abnormal_immune_system1.89311043
33MP0005387_immune_system_phenotype1.89311043
34MP0001819_abnormal_immune_cell1.89224793
35MP0005025_abnormal_response_to1.88102350
36MP0008058_abnormal_DNA_repair1.80801300
37MP0009697_abnormal_copulation1.75768116
38MP0006072_abnormal_retinal_apoptosis1.73549614
39MP0000465_gastrointestinal_hemorrhage1.71368721
40MP0002396_abnormal_hematopoietic_system1.67260329
41MP0002938_white_spotting1.67058115
42MP0010094_abnormal_chromosome_stability1.66732631
43MP0002006_tumorigenesis1.66485824
44MP0001529_abnormal_vocalization1.64680947
45MP0003122_maternal_imprinting1.56718571
46MP0004147_increased_porphyrin_level1.53668002
47MP0000685_abnormal_immune_system1.53357658
48MP0003937_abnormal_limbs/digits/tail_de1.52824647
49MP0005171_absent_coat_pigmentation1.50735733
50MP0002398_abnormal_bone_marrow1.49826798
51MP0000716_abnormal_immune_system1.49375816
52MP0000490_abnormal_crypts_of1.48065434
53MP0002405_respiratory_system_inflammati1.48024187
54MP0008260_abnormal_autophagy1.47750028
55MP0003123_paternal_imprinting1.47570348
56MP0008995_early_reproductive_senescence1.47245486
57MP0009333_abnormal_splenocyte_physiolog1.46653317
58MP0003303_peritoneal_inflammation1.44841145
59MP0003880_abnormal_central_pattern1.42056458
60MP0001853_heart_inflammation1.40178725
61MP0003183_abnormal_peptide_metabolism1.39526396
62MP0003693_abnormal_embryo_hatching1.38531150
63MP0000372_irregular_coat_pigmentation1.38308695
64MP0010155_abnormal_intestine_physiology1.37690912
65MP0002234_abnormal_pharynx_morphology1.35577735
66MP0002933_joint_inflammation1.33855842
67MP0005187_abnormal_penis_morphology1.33341573
68MP0000778_abnormal_nervous_system1.31941483
69MP0003567_abnormal_fetal_cardiomyocyte1.30814463
70MP0001873_stomach_inflammation1.29713209
71MP0003718_maternal_effect1.29172464
72MP0002102_abnormal_ear_morphology1.27857525
73MP0000689_abnormal_spleen_morphology1.25801090
74MP0002084_abnormal_developmental_patter1.21579123
75MP0002210_abnormal_sex_determination1.20666044
76MP0002160_abnormal_reproductive_system1.20145090
77MP0000537_abnormal_urethra_morphology1.18988770
78MP0006082_CNS_inflammation1.18509865
79MP0008007_abnormal_cellular_replicative1.17821669
80MP0005253_abnormal_eye_physiology1.17411604
81MP0002429_abnormal_blood_cell1.17389464
82MP0003786_premature_aging1.16830051
83MP0001293_anophthalmia1.16736146
84MP0002697_abnormal_eye_size1.16494678
85MP0003077_abnormal_cell_cycle1.16355638
86MP0001929_abnormal_gametogenesis1.15813348
87MP0001984_abnormal_olfaction1.14727942
88MP0002722_abnormal_immune_system1.14707704
89MP0000631_abnormal_neuroendocrine_gland1.13602011
90MP0001845_abnormal_inflammatory_respons1.08387054
91MP0001697_abnormal_embryo_size1.08303595
92MP0005248_abnormal_Harderian_gland1.07286488
93MP0001186_pigmentation_phenotype1.06923992
94MP0001730_embryonic_growth_arrest1.06395579
95MP0001145_abnormal_male_reproductive1.06083562
96MP0002233_abnormal_nose_morphology1.05992212
97MP0006035_abnormal_mitochondrial_morpho1.05625243
98MP0001672_abnormal_embryogenesis/_devel1.04655217
99MP0005380_embryogenesis_phenotype1.04655217
100MP0003866_abnormal_defecation1.04547673
101MP0009703_decreased_birth_body1.03634607
102MP0001299_abnormal_eye_distance/1.03514326
103MP0000858_altered_metastatic_potential1.02525878
104MP0003119_abnormal_digestive_system1.01564644
105MP0002184_abnormal_innervation1.01545620
106MP0000653_abnormal_sex_gland1.00965779
107MP0000647_abnormal_sebaceous_gland0.99800000
108MP0004197_abnormal_fetal_growth/weight/0.99649023
109MP0003111_abnormal_nucleus_morphology0.99007117
110MP0001286_abnormal_eye_development0.98821006
111MP0002085_abnormal_embryonic_tissue0.98771499
112MP0000703_abnormal_thymus_morphology0.98572657
113MP0003828_pulmonary_edema0.98572419
114MP0002822_catalepsy0.98570779
115MP0002075_abnormal_coat/hair_pigmentati0.98484256
116MP0006276_abnormal_autonomic_nervous0.98170667
117MP0005464_abnormal_platelet_physiology0.98127570
118MP0002751_abnormal_autonomic_nervous0.97856097
119MP0003172_abnormal_lysosome_physiology0.97791783
120MP0003698_abnormal_male_reproductive0.95749993
121MP0009672_abnormal_birth_weight0.95363958
122MP0009046_muscle_twitch0.95240634
123MP0009780_abnormal_chondrocyte_physiolo0.95027882
124MP0003861_abnormal_nervous_system0.94802795
125MP0003984_embryonic_growth_retardation0.94423492
126MP0002132_abnormal_respiratory_system0.94158064
127MP0002090_abnormal_vision0.94012306
128MP0002088_abnormal_embryonic_growth/wei0.93740694
129MP0010307_abnormal_tumor_latency0.93640356
130MP0000613_abnormal_salivary_gland0.91489673
131MP0001661_extended_life_span0.90730574
132MP0001533_abnormal_skeleton_physiology0.89651513
133MP0008789_abnormal_olfactory_epithelium0.89506583
134MP0004270_analgesia0.89421720
135MP0005220_abnormal_exocrine_pancreas0.88425847
136MP0002837_dystrophic_cardiac_calcinosis0.88045351
137MP0002638_abnormal_pupillary_reflex0.86432017
138MP0005551_abnormal_eye_electrophysiolog0.86336873
139MP0000350_abnormal_cell_proliferation0.86323683
140MP0005391_vision/eye_phenotype0.86213198
141MP0002909_abnormal_adrenal_gland0.85307026
142MP0000371_diluted_coat_color0.85250167
143MP0002876_abnormal_thyroid_physiology0.83663655
144MP0005379_endocrine/exocrine_gland_phen0.83180731
145MP0002877_abnormal_melanocyte_morpholog0.82800658
146MP0000427_abnormal_hair_cycle0.81895830
147MP0003935_abnormal_craniofacial_develop0.81363996
148MP0000358_abnormal_cell_content/0.81356934
149MP0005499_abnormal_olfactory_system0.80235839
150MP0005394_taste/olfaction_phenotype0.80235839
151MP0010352_gastrointestinal_tract_polyps0.80035096
152MP0003448_altered_tumor_morphology0.79848695
153MP0005367_renal/urinary_system_phenotyp0.79478460
154MP0000516_abnormal_urinary_system0.79478460
155MP0000955_abnormal_spinal_cord0.78832858
156MP0003941_abnormal_skin_development0.78707316
157MP0002080_prenatal_lethality0.78430542
158MP0003385_abnormal_body_wall0.78425571
159MP0005058_abnormal_lysosome_morphology0.76175418
160MP0005310_abnormal_salivary_gland0.75836440
161MP0002177_abnormal_outer_ear0.75195906
162MP0000566_synostosis0.72914709
163MP0005408_hypopigmentation0.70747507
164MP0004782_abnormal_surfactant_physiolog0.70715085
165MP0002998_abnormal_bone_remodeling0.69842705
166MP0001919_abnormal_reproductive_system0.69624602
167MP0002693_abnormal_pancreas_physiology0.68140706
168MP0000569_abnormal_digit_pigmentation0.66874133
169MP0002019_abnormal_tumor_incidence0.66422110
170MP0001851_eye_inflammation0.65745225
171MP0003787_abnormal_imprinting0.65727996
172MP0008932_abnormal_embryonic_tissue0.65635546
173MP0008469_abnormal_protein_level0.65317656
174MP0003300_gastrointestinal_ulcer0.64534217
175MP0005645_abnormal_hypothalamus_physiol0.63298316
176MP0000681_abnormal_thyroid_gland0.62340446
177MP0003315_abnormal_perineum_morphology0.58384896
178MP0008877_abnormal_DNA_methylation0.58165767

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.38354408
2Reduced antithrombin III activity (HP:0001976)4.01872694
3Volvulus (HP:0002580)3.62664867
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54085411
5Chromsome breakage (HP:0040012)3.53019579
6Recurrent abscess formation (HP:0002722)3.41571850
7Obstructive lung disease (HP:0006536)3.25770711
8Chronic obstructive pulmonary disease (HP:0006510)3.25770711
9Reticulocytopenia (HP:0001896)3.21500464
10Stomatitis (HP:0010280)3.16969526
11Meningitis (HP:0001287)2.94668666
12Abnormal protein N-linked glycosylation (HP:0012347)2.91564229
13Abnormal protein glycosylation (HP:0012346)2.91564229
14Abnormal glycosylation (HP:0012345)2.91564229
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91564229
16Duplicated collecting system (HP:0000081)2.90978978
17IgM deficiency (HP:0002850)2.89909252
18Abnormality of the labia minora (HP:0012880)2.81484993
19Agammaglobulinemia (HP:0004432)2.75954229
20Abnormality of the renal collecting system (HP:0004742)2.75745784
21Cortical dysplasia (HP:0002539)2.72520636
22Abnormality of the prostate (HP:0008775)2.64821227
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62149802
24Hypothermia (HP:0002045)2.61723281
25Recurrent bacterial skin infections (HP:0005406)2.61552629
26Recurrent cutaneous fungal infections (HP:0011370)2.55608625
27Chronic mucocutaneous candidiasis (HP:0002728)2.55608625
28Retrobulbar optic neuritis (HP:0100654)2.52781955
29Optic neuritis (HP:0100653)2.52781955
30Recurrent bronchitis (HP:0002837)2.50937016
31Abnormality of the axillary hair (HP:0100134)2.50714418
32Abnormality of secondary sexual hair (HP:0009888)2.50714418
33Eczematoid dermatitis (HP:0000976)2.49082408
34Agnosia (HP:0010524)2.46582194
35Recurrent pneumonia (HP:0006532)2.44208723
3611 pairs of ribs (HP:0000878)2.43182876
37T lymphocytopenia (HP:0005403)2.42759160
38Increased nuchal translucency (HP:0010880)2.40840269
39Myositis (HP:0100614)2.40758535
40Nephroblastoma (Wilms tumor) (HP:0002667)2.39609881
41Thrombocytosis (HP:0001894)2.39087176
42Recurrent viral infections (HP:0004429)2.36645274
43Abnormal sex determination (HP:0012244)2.33284874
44Sex reversal (HP:0012245)2.33284874
45Mediastinal lymphadenopathy (HP:0100721)2.32496836
46Abnormality of T cell number (HP:0011839)2.32126343
47Abnormality of the preputium (HP:0100587)2.31665573
48Embryonal renal neoplasm (HP:0011794)2.29917436
49Abnormality of DNA repair (HP:0003254)2.29554702
50Colon cancer (HP:0003003)2.29405922
51Abnormal lung lobation (HP:0002101)2.29060676
52Dry hair (HP:0011359)2.28340595
53Recurrent fungal infections (HP:0002841)2.26484176
54Abnormality of chromosome stability (HP:0003220)2.25706859
55Chronic diarrhea (HP:0002028)2.25671269
56Elevated erythrocyte sedimentation rate (HP:0003565)2.23892064
57Abnormality of the astrocytes (HP:0100707)2.22335138
58Astrocytoma (HP:0009592)2.22335138
59Tubulointerstitial nephritis (HP:0001970)2.21615312
60White forelock (HP:0002211)2.21408223
61Hypoglycemic coma (HP:0001325)2.21075755
62Vasculitis (HP:0002633)2.20887934
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20304160
64Gonadotropin excess (HP:0000837)2.19323509
65Clubbing of toes (HP:0100760)2.18924212
66Attenuation of retinal blood vessels (HP:0007843)2.17880827
67Recurrent sinusitis (HP:0011108)2.16330462
68Patchy hypopigmentation of hair (HP:0011365)2.15912826
69True hermaphroditism (HP:0010459)2.15488777
70Glioma (HP:0009733)2.13603864
71Papillary thyroid carcinoma (HP:0002895)2.12787838
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.11692136
73Medulloblastoma (HP:0002885)2.11593036
74Lymphoma (HP:0002665)2.10944777
75Hyperinsulinemic hypoglycemia (HP:0000825)2.10734523
76Congenital primary aphakia (HP:0007707)2.10192028
77Gait imbalance (HP:0002141)2.09500600
78Ocular albinism (HP:0001107)2.09120795
79Recurrent skin infections (HP:0001581)2.07488966
80Renal cortical cysts (HP:0000803)2.06272450
81Orchitis (HP:0100796)2.06115390
82Pulmonary infiltrates (HP:0002113)2.05891255
83Rhabdomyosarcoma (HP:0002859)2.05644186
84Duodenal stenosis (HP:0100867)2.05417209
85Small intestinal stenosis (HP:0012848)2.05417209
86Ependymoma (HP:0002888)2.03568683
87Panhypogammaglobulinemia (HP:0003139)2.02393831
88Exertional dyspnea (HP:0002875)2.01490283
89Abnormality of the duodenum (HP:0002246)2.00773271
90Prostate neoplasm (HP:0100787)1.99502650
91Medial flaring of the eyebrow (HP:0010747)1.98757811
92Thyroid carcinoma (HP:0002890)1.98286663
93Abnormality of T cells (HP:0002843)1.97845345
94IgG deficiency (HP:0004315)1.97324903
95Hypoglycemic seizures (HP:0002173)1.95261168
96Microvesicular hepatic steatosis (HP:0001414)1.94338281
97Cellulitis (HP:0100658)1.94280493
98Hemoptysis (HP:0002105)1.92829515
99Ectopic kidney (HP:0000086)1.92570469
100B lymphocytopenia (HP:0010976)1.91265731
101Abnormality of B cell number (HP:0010975)1.91265731
102Neoplasm of the adrenal cortex (HP:0100641)1.91005150
103Genital tract atresia (HP:0001827)1.90361981
104Nephrogenic diabetes insipidus (HP:0009806)1.90269640
105Amaurosis fugax (HP:0100576)1.90260599
106Sloping forehead (HP:0000340)1.89631309
107Abnormality of the carotid arteries (HP:0005344)1.89094082
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.88966296
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88966296
110Lymphopenia (HP:0001888)1.87434677
111Pulmonary fibrosis (HP:0002206)1.86890660
112Abnormal delayed hypersensitivity skin test (HP:0002963)1.86439756
113Myelodysplasia (HP:0002863)1.86274694
114Intestinal atresia (HP:0011100)1.85672632
115Meckel diverticulum (HP:0002245)1.85623966
116Bone marrow hypocellularity (HP:0005528)1.85037200
117Recurrent lower respiratory tract infections (HP:0002783)1.84978101
118Abnormality of macrophages (HP:0004311)1.84434644
119Absent radius (HP:0003974)1.83583483
120Absent thumb (HP:0009777)1.83034792
121Vaginal atresia (HP:0000148)1.82999710
122Chronic otitis media (HP:0000389)1.82875473
123Spontaneous hematomas (HP:0007420)1.82073778
124Thyroid-stimulating hormone excess (HP:0002925)1.80905943
125Eosinophilia (HP:0001880)1.80687788
126Abnormality of T cell physiology (HP:0011840)1.79740459
127Pancreatic fibrosis (HP:0100732)1.79528906
128Premature graying of hair (HP:0002216)1.79202274
129Oligodactyly (hands) (HP:0001180)1.78949541
130Degeneration of anterior horn cells (HP:0002398)1.78616058
131Abnormality of the anterior horn cell (HP:0006802)1.78616058
132Abnormality of glycolysis (HP:0004366)1.77814007
133Poor coordination (HP:0002370)1.77752648
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.76925534
135Basal ganglia calcification (HP:0002135)1.75237045
136Vacuolated lymphocytes (HP:0001922)1.74111801
137Aplasia involving forearm bones (HP:0009822)1.73958485
138Absent forearm bone (HP:0003953)1.73958485
139Increased hepatocellular lipid droplets (HP:0006565)1.73584372
140Pancreatic islet-cell hyperplasia (HP:0004510)1.72749129
141Thyroiditis (HP:0100646)1.72630005
142Abnormality of the corticospinal tract (HP:0002492)1.72245984
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.71650672
144Encephalitis (HP:0002383)1.71298798
145Iris hypopigmentation (HP:0007730)1.71072410
146Abnormality of the ileum (HP:0001549)1.70717605
147Pallor (HP:0000980)1.69857394
148Embryonal neoplasm (HP:0002898)1.69280237
149Impaired vibration sensation in the lower limbs (HP:0002166)1.68502512
150Drooling (HP:0002307)1.67232116
151Aqueductal stenosis (HP:0002410)1.66876200
152Abnormality of the pancreatic islet cells (HP:0006476)1.65555405
153Abnormality of endocrine pancreas physiology (HP:0012093)1.65555405
154Birth length less than 3rd percentile (HP:0003561)1.64870924
155Triphalangeal thumb (HP:0001199)1.64701558
156Ovarian neoplasm (HP:0100615)1.63197942
157Hepatoblastoma (HP:0002884)1.61983447
158Breast carcinoma (HP:0003002)1.61521894
159Pheochromocytoma (HP:0002666)1.60859243
160Neoplasm of the oral cavity (HP:0100649)1.60585175
161Nephronophthisis (HP:0000090)1.59908972
162Termporal pattern (HP:0011008)1.58178122
163Insidious onset (HP:0003587)1.58178122
164Pancreatic cysts (HP:0001737)1.56695258
165Methylmalonic acidemia (HP:0002912)1.55590189
166Abnormality of the renal cortex (HP:0011035)1.55491678
167Astigmatism (HP:0000483)1.53334381
168Gastrointestinal atresia (HP:0002589)1.52834346
169Hyperglycinemia (HP:0002154)1.52651443
170Increased serum pyruvate (HP:0003542)1.51673381
171Neoplasm of the adrenal gland (HP:0100631)1.51060770
172Acute encephalopathy (HP:0006846)1.49912040
173Congenital malformation of the right heart (HP:0011723)1.48964284
174Double outlet right ventricle (HP:0001719)1.48964284
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.48167830
176Shoulder girdle muscle weakness (HP:0003547)1.47983388
177Micropenis (HP:0000054)1.47793547
178Neoplasm of striated muscle (HP:0009728)1.47635811
179Cafe-au-lait spot (HP:0000957)1.47224149
180Cerebral edema (HP:0002181)1.46894228
181Short tibia (HP:0005736)1.46615023
182Ketoacidosis (HP:0001993)1.46601046
183Abnormality of methionine metabolism (HP:0010901)1.46594176
184Neuroendocrine neoplasm (HP:0100634)1.44728150
185Male pseudohermaphroditism (HP:0000037)1.44615072
186Bifid tongue (HP:0010297)1.44228701
187Decreased testicular size (HP:0008734)1.43892037
188Neoplasm of the colon (HP:0100273)1.43888946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.93635752
2MKNK23.22551469
3IRAK42.99246921
4TNIK2.94300606
5CASK2.84836125
6IRAK32.73225783
7PNCK2.69016030
8TXK2.56998404
9STK162.50417387
10TLK12.46053810
11NEK12.41133062
12MKNK12.22352754
13TEC2.21272522
14MAP3K142.18358027
15BLK2.15246213
16MAP3K42.10634839
17BRSK21.98129756
18TRIM281.96322123
19WNK31.95072201
20ERBB31.94955437
21MAP4K11.89978996
22EIF2AK21.86024105
23PLK31.85503168
24CLK11.83858263
25FES1.74995723
26PRPF4B1.74422267
27MAP4K21.73979516
28NLK1.73030525
29TAF11.71016411
30EIF2AK11.70851665
31BMPR1B1.52556581
32YES11.47748677
33SRPK11.44763127
34VRK11.42089509
35PLK21.41688950
36PLK11.34560997
37ZAK1.32517542
38BTK1.29073551
39NME21.28870690
40CCNB11.25541885
41MST41.24062341
42IKBKE1.23805239
43ACVR1B1.19966084
44STK38L1.19655130
45MAP3K131.19417510
46PBK1.19226683
47KIT1.18809713
48NEK21.18032940
49CSK1.17202253
50CSNK1G11.16634273
51JAK31.14707733
52BRSK11.12890336
53MARK11.11945535
54AKT31.09178735
55MAPK131.08838598
56CAMKK21.08057303
57PDK21.07383221
58TGFBR21.07347841
59BMPR21.06054404
60LCK1.05757233
61IKBKB1.05358167
62NUAK11.05195650
63NEK91.02941593
64CSNK1G21.02803548
65WNK41.01916589
66CSNK1G31.01416233
67FGFR21.00865608
68LYN0.99790923
69CHEK20.99044310
70VRK20.98187365
71MAPK150.97894640
72SCYL20.95599693
73ITK0.93561909
74CDC70.93034458
75STK30.90981773
76PINK10.90819042
77TAOK30.90606241
78STK100.90556746
79CSNK1A1L0.90333942
80PLK40.90236073
81ZAP700.89584810
82CDK30.88038343
83GRK70.87207365
84TYK20.86682483
85LATS10.86074165
86SYK0.85159484
87KSR10.80257944
88IRAK10.79253997
89CHEK10.78228797
90PAK30.76646406
91ERBB40.75958273
92IRAK20.75477629
93RPS6KA50.72739434
94HCK0.68398294
95CDK190.68319722
96FRK0.68106065
97GRK10.67802547
98RPS6KA40.66303663
99CSNK1E0.65744737
100CSF1R0.64452998
101ATR0.64215678
102RIPK40.62869925
103CAMK1G0.62764641
104CDK10.62006018
105ADRBK20.61958000
106TNK20.60152208
107STK40.59153206
108CDK90.57915111
109EPHA40.57841611
110INSRR0.56931933
111CDK80.56916308
112DYRK20.56612827
113TRPM70.56018284
114NEK60.55924416
115HIPK20.55640269
116PRKDC0.54718539
117BRD40.54345023
118PIM10.53863950
119PASK0.53613306
120MINK10.52858958
121FGFR10.52664296
122MAP2K70.52653014
123JAK10.49882328
124WEE10.49121207
125CDK20.48714688
126BUB10.48683638
127PKN10.48347931
128MET0.47463686
129DYRK30.46673678
130PRKCE0.46245995
131RPS6KB20.46100280
132PHKG10.45723033
133PHKG20.45723033
134FER0.45527076
135NTRK30.44250440
136PRKCQ0.44173669
137PKN20.42466556
138TGFBR10.41923176
139* CSNK2A20.41654015
140PRKCG0.41136739
141AURKA0.40955217
142ATM0.40016382
143CDK180.39889472
144MAP2K40.39793107
145PRKD20.39297215
146STK390.38617538
147CDK40.38431243
148AURKB0.38097980
149UHMK10.37093426
150DYRK1A0.36723663
151CHUK0.36460511
152MAPKAPK50.36400083
153CSNK1D0.36399950
154TSSK60.35355097
155FLT30.34782916
156BCR0.33852279
157MUSK0.32746408
158CDK70.31821194
159OXSR10.30876371
160TTK0.27176347
161ABL10.27130594
162SIK30.26377159

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.00598131
2Mismatch repair_Homo sapiens_hsa034302.91103687
3Protein export_Homo sapiens_hsa030602.70841815
4Primary immunodeficiency_Homo sapiens_hsa053402.49248171
5Homologous recombination_Homo sapiens_hsa034402.47766259
6Ribosome_Homo sapiens_hsa030102.43849669
7Fanconi anemia pathway_Homo sapiens_hsa034602.42277391
8Propanoate metabolism_Homo sapiens_hsa006402.31817866
9Other glycan degradation_Homo sapiens_hsa005112.15408269
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03021002
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02493216
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.00379548
13Nucleotide excision repair_Homo sapiens_hsa034201.88593314
14Steroid biosynthesis_Homo sapiens_hsa001001.79337866
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78843619
16Base excision repair_Homo sapiens_hsa034101.78075324
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75875259
18Non-homologous end-joining_Homo sapiens_hsa034501.72077637
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66506776
20Hematopoietic cell lineage_Homo sapiens_hsa046401.65484720
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.63957181
22Pyruvate metabolism_Homo sapiens_hsa006201.62958753
23Leishmaniasis_Homo sapiens_hsa051401.53277433
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52671865
25Measles_Homo sapiens_hsa051621.50949801
26Fatty acid elongation_Homo sapiens_hsa000621.49517627
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48822645
28Antigen processing and presentation_Homo sapiens_hsa046121.48458779
29RNA polymerase_Homo sapiens_hsa030201.45988298
30Butanoate metabolism_Homo sapiens_hsa006501.45429789
31Graft-versus-host disease_Homo sapiens_hsa053321.44109003
32Allograft rejection_Homo sapiens_hsa053301.42856075
33Basal transcription factors_Homo sapiens_hsa030221.42533875
34Selenocompound metabolism_Homo sapiens_hsa004501.41979716
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40222557
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40064859
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.39831130
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38453340
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37870224
40Oocyte meiosis_Homo sapiens_hsa041141.35948653
41Spliceosome_Homo sapiens_hsa030401.35778633
42Phototransduction_Homo sapiens_hsa047441.34192201
43Sphingolipid metabolism_Homo sapiens_hsa006001.33635416
44Autoimmune thyroid disease_Homo sapiens_hsa053201.33342271
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30656331
46Systemic lupus erythematosus_Homo sapiens_hsa053221.28268740
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26407769
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24355215
49mRNA surveillance pathway_Homo sapiens_hsa030151.23879136
50Osteoclast differentiation_Homo sapiens_hsa043801.20384870
51Herpes simplex infection_Homo sapiens_hsa051681.20234904
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19866257
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19538039
54Vitamin B6 metabolism_Homo sapiens_hsa007501.18695822
55Carbon metabolism_Homo sapiens_hsa012001.15393877
56Malaria_Homo sapiens_hsa051441.15281150
57Fatty acid metabolism_Homo sapiens_hsa012121.12831201
58RNA degradation_Homo sapiens_hsa030181.12226454
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12210426
60Asthma_Homo sapiens_hsa053101.10351792
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09821374
62Biosynthesis of amino acids_Homo sapiens_hsa012301.09402263
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09084264
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07748943
65B cell receptor signaling pathway_Homo sapiens_hsa046621.06153234
66Pyrimidine metabolism_Homo sapiens_hsa002401.04102800
67One carbon pool by folate_Homo sapiens_hsa006701.02396914
68Pertussis_Homo sapiens_hsa051331.01559737
69Folate biosynthesis_Homo sapiens_hsa007901.01483733
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99791909
71N-Glycan biosynthesis_Homo sapiens_hsa005100.99438209
72Oxidative phosphorylation_Homo sapiens_hsa001900.99324076
73Arachidonic acid metabolism_Homo sapiens_hsa005900.99012341
74Cell cycle_Homo sapiens_hsa041100.97333942
75Parkinsons disease_Homo sapiens_hsa050120.95464044
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94773547
77T cell receptor signaling pathway_Homo sapiens_hsa046600.91538720
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.90961332
79Nicotine addiction_Homo sapiens_hsa050330.90223682
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86823008
81Lysine degradation_Homo sapiens_hsa003100.85748565
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85636880
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85597022
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.84282637
85p53 signaling pathway_Homo sapiens_hsa041150.83525525
86Influenza A_Homo sapiens_hsa051640.83446326
87Rheumatoid arthritis_Homo sapiens_hsa053230.82407726
88Huntingtons disease_Homo sapiens_hsa050160.82341018
89Purine metabolism_Homo sapiens_hsa002300.80962392
90Phagosome_Homo sapiens_hsa041450.78269889
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78189141
92Staphylococcus aureus infection_Homo sapiens_hsa051500.77512840
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.76734253
94Tuberculosis_Homo sapiens_hsa051520.76461283
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75342353
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.74420859
97Legionellosis_Homo sapiens_hsa051340.72663060
98Type I diabetes mellitus_Homo sapiens_hsa049400.72589810
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71734473
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70963043
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70813662
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70628705
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68958490
104Epstein-Barr virus infection_Homo sapiens_hsa051690.68393163
105Hepatitis B_Homo sapiens_hsa051610.67402821
106Renin-angiotensin system_Homo sapiens_hsa046140.67367154
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65481941
108Hippo signaling pathway_Homo sapiens_hsa043900.63654281
109Circadian rhythm_Homo sapiens_hsa047100.63622813
110Ether lipid metabolism_Homo sapiens_hsa005650.61927216
111Viral carcinogenesis_Homo sapiens_hsa052030.60356654
112Salmonella infection_Homo sapiens_hsa051320.59990808
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59637123
114TGF-beta signaling pathway_Homo sapiens_hsa043500.58993948
115Arginine and proline metabolism_Homo sapiens_hsa003300.58565182
116Lysosome_Homo sapiens_hsa041420.58109659
117RNA transport_Homo sapiens_hsa030130.57898434
118Chemokine signaling pathway_Homo sapiens_hsa040620.57566016
119Hedgehog signaling pathway_Homo sapiens_hsa043400.57519139
120Peroxisome_Homo sapiens_hsa041460.57095768
121Proteasome_Homo sapiens_hsa030500.55929703
122beta-Alanine metabolism_Homo sapiens_hsa004100.55158499
123Metabolic pathways_Homo sapiens_hsa011000.55026397
124Toxoplasmosis_Homo sapiens_hsa051450.54833487
125Basal cell carcinoma_Homo sapiens_hsa052170.52603039
126African trypanosomiasis_Homo sapiens_hsa051430.52123772
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51680583
128Apoptosis_Homo sapiens_hsa042100.51538557
129Alzheimers disease_Homo sapiens_hsa050100.50963537
130Wnt signaling pathway_Homo sapiens_hsa043100.50609248
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50451834
132Shigellosis_Homo sapiens_hsa051310.49500154
133TNF signaling pathway_Homo sapiens_hsa046680.48493310
134HTLV-I infection_Homo sapiens_hsa051660.48350616
135Pentose phosphate pathway_Homo sapiens_hsa000300.47019118
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46750353
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45884819
138Hepatitis C_Homo sapiens_hsa051600.45216625
139Taste transduction_Homo sapiens_hsa047420.45118408
140Thyroid cancer_Homo sapiens_hsa052160.44536669
141Dopaminergic synapse_Homo sapiens_hsa047280.44477275
142Fatty acid degradation_Homo sapiens_hsa000710.43196945
143Arginine biosynthesis_Homo sapiens_hsa002200.42408767
144Glutathione metabolism_Homo sapiens_hsa004800.42062223
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41995330
146GABAergic synapse_Homo sapiens_hsa047270.41882854
147Nitrogen metabolism_Homo sapiens_hsa009100.39572934
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38728572
149Alcoholism_Homo sapiens_hsa050340.38267948
150Insulin secretion_Homo sapiens_hsa049110.36005988
151Platelet activation_Homo sapiens_hsa046110.35516572
152Amphetamine addiction_Homo sapiens_hsa050310.35299273
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35095036
154Linoleic acid metabolism_Homo sapiens_hsa005910.33895156
155Prostate cancer_Homo sapiens_hsa052150.33769162
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33589679
157Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33372223
158Cardiac muscle contraction_Homo sapiens_hsa042600.33057874
159Tryptophan metabolism_Homo sapiens_hsa003800.32588751
160Glutamatergic synapse_Homo sapiens_hsa047240.30884270
161Regulation of autophagy_Homo sapiens_hsa041400.29948943
162Circadian entrainment_Homo sapiens_hsa047130.29672240
163Colorectal cancer_Homo sapiens_hsa052100.28981540
164Fatty acid biosynthesis_Homo sapiens_hsa000610.28465568
165Olfactory transduction_Homo sapiens_hsa047400.27925846
166Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27905901
167Tight junction_Homo sapiens_hsa045300.27479260
168Central carbon metabolism in cancer_Homo sapiens_hsa052300.26535041
169AMPK signaling pathway_Homo sapiens_hsa041520.26087566

Most similar genes based on co-expression Upload to Enrichr

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