HMBOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational termination (GO:0006449)5.73411124
2protein localization to kinetochore (GO:0034501)5.54680757
3synaptic vesicle maturation (GO:0016188)4.79721175
4dicarboxylic acid biosynthetic process (GO:0043650)4.70726749
5neural tube formation (GO:0001841)4.51116368
6interkinetic nuclear migration (GO:0022027)4.50472643
7negative regulation of cytosolic calcium ion concentration (GO:0051481)4.34770968
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.33482212
9regulation of sarcomere organization (GO:0060297)4.18707131
10peptidyl-lysine dimethylation (GO:0018027)4.10361067
11glutamate secretion (GO:0014047)4.06730001
12monoubiquitinated protein deubiquitination (GO:0035520)4.05998901
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.05239530
14cilium or flagellum-dependent cell motility (GO:0001539)4.03218216
15centriole replication (GO:0007099)4.02632647
16locomotory exploration behavior (GO:0035641)3.91175872
17response to pheromone (GO:0019236)3.82671930
18layer formation in cerebral cortex (GO:0021819)3.82232852
19protein localization to chromosome, centromeric region (GO:0071459)3.74126979
20establishment of protein localization to Golgi (GO:0072600)3.71288086
21histone H3-K9 methylation (GO:0051567)3.69041442
22negative regulation of translation, ncRNA-mediated (GO:0040033)3.67160262
23regulation of translation, ncRNA-mediated (GO:0045974)3.67160262
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.67160262
25regulation of protein polyubiquitination (GO:1902914)3.65725485
26regulation of RNA export from nucleus (GO:0046831)3.53716825
27pre-miRNA processing (GO:0031054)3.44303581
28regulation of nucleobase-containing compound transport (GO:0032239)3.42330844
29N-terminal protein amino acid acetylation (GO:0006474)3.42021954
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36442200
31protein targeting to Golgi (GO:0000042)3.33882195
32histone H3-K9 demethylation (GO:0033169)3.33492497
33histone H3-K9 modification (GO:0061647)3.33440648
34mitotic sister chromatid cohesion (GO:0007064)3.26568178
35cerebellar Purkinje cell differentiation (GO:0021702)3.23797770
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23785067
37negative regulation of histone methylation (GO:0031061)3.23162019
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.18448533
39retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17938395
40peptidyl-threonine phosphorylation (GO:0018107)3.16752218
41vesicle transport along microtubule (GO:0047496)3.16452055
42establishment of nucleus localization (GO:0040023)3.15287420
43microtubule anchoring (GO:0034453)3.15286860
44piRNA metabolic process (GO:0034587)3.12603927
45negative regulation of cAMP-mediated signaling (GO:0043951)3.11259403
46nuclear pore complex assembly (GO:0051292)3.10332262
47vocalization behavior (GO:0071625)3.09474255
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.07088776
49sodium ion export (GO:0071436)3.06797735
50cellular potassium ion homeostasis (GO:0030007)3.05055808
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04767447
52proline transport (GO:0015824)3.03937558
53spindle assembly involved in mitosis (GO:0090307)3.02168859
54histone phosphorylation (GO:0016572)3.01067495
55positive regulation of fibroblast migration (GO:0010763)2.99772471
56suckling behavior (GO:0001967)2.99717797
57chromatin silencing (GO:0006342)2.99379535
58peptidyl-threonine modification (GO:0018210)2.98988647
59nucleus localization (GO:0051647)2.98952074
60ionotropic glutamate receptor signaling pathway (GO:0035235)2.97600047
61neurotransmitter secretion (GO:0007269)2.96515616
62regulation of DNA damage checkpoint (GO:2000001)2.96426325
63regulation of meiosis I (GO:0060631)2.95459613
64protein localization to Golgi apparatus (GO:0034067)2.94486573
65nuclear pore organization (GO:0006999)2.93323299
66histone mRNA catabolic process (GO:0071044)2.91065499
67behavioral response to nicotine (GO:0035095)2.90526564
68dentate gyrus development (GO:0021542)2.90326273
69prenylation (GO:0097354)2.89292011
70protein prenylation (GO:0018342)2.89292011
71pyrimidine nucleobase catabolic process (GO:0006208)2.88989027
72cell communication by electrical coupling (GO:0010644)2.87697093
73regulation of DNA methylation (GO:0044030)2.85134769
74branching involved in prostate gland morphogenesis (GO:0060442)2.84738392
75regulation of Rac protein signal transduction (GO:0035020)2.84120953
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83794505
77neuromuscular process controlling balance (GO:0050885)2.82562140
78epithelial cilium movement (GO:0003351)2.81271109
79centriole assembly (GO:0098534)2.78804848
80microtubule nucleation (GO:0007020)2.78394978
81cilium movement (GO:0003341)2.78331766
82DNA methylation involved in gamete generation (GO:0043046)2.77965002
83regulation of clathrin-mediated endocytosis (GO:2000369)2.75856057
84regulation of hexokinase activity (GO:1903299)2.75389457
85regulation of glucokinase activity (GO:0033131)2.75389457
86protein localization to chromosome (GO:0034502)2.74418253
87plasma membrane repair (GO:0001778)2.73831556
88peptidyl-lysine methylation (GO:0018022)2.72619445
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71527366
90clathrin coat assembly (GO:0048268)2.71379224
91regulation of DNA endoreduplication (GO:0032875)2.70622472
92regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70145317
93membrane depolarization during action potential (GO:0086010)2.69906769
94intraciliary transport (GO:0042073)2.68266377
95positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.68008449
96phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.65909378
97regulation of glutamate receptor signaling pathway (GO:1900449)2.65745902
98neuronal action potential (GO:0019228)2.65549112
99sperm motility (GO:0030317)2.64857216
100positive regulation of granulocyte differentiation (GO:0030854)2.63795534
101photoreceptor cell maintenance (GO:0045494)2.63733832
102activation of protein kinase A activity (GO:0034199)2.62339736
103regulation of synaptic vesicle exocytosis (GO:2000300)2.62294443
104synaptic vesicle exocytosis (GO:0016079)2.61978184
105regulation of neuronal synaptic plasticity (GO:0048168)2.61881495
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61761142
107cytoplasmic mRNA processing body assembly (GO:0033962)2.61590495
108regulation of establishment of cell polarity (GO:2000114)2.61468370
109gamma-aminobutyric acid transport (GO:0015812)2.61398192
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61365143
111regulation of centriole replication (GO:0046599)2.61104036
112regulation of synapse structural plasticity (GO:0051823)2.59612277
113regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59244906
114protein localization to endosome (GO:0036010)2.58642168
115synapsis (GO:0007129)2.57945031
116cell communication involved in cardiac conduction (GO:0086065)2.57901915
117nuclear envelope disassembly (GO:0051081)2.57645540
118membrane disassembly (GO:0030397)2.57645540
119regulation of female gonad development (GO:2000194)2.57515979
120axoneme assembly (GO:0035082)2.56465631
121definitive hemopoiesis (GO:0060216)2.56465530
122dendritic spine morphogenesis (GO:0060997)2.56447215
123peptidyl-lysine trimethylation (GO:0018023)2.56369643
124positive regulation of protein import into nucleus, translocation (GO:0033160)2.55040676
125regulation of dendritic spine morphogenesis (GO:0061001)2.54638895
126stress granule assembly (GO:0034063)2.52982908
127behavioral response to ethanol (GO:0048149)2.52888821
128regulation of pigment cell differentiation (GO:0050932)2.51478713
129NLS-bearing protein import into nucleus (GO:0006607)2.50729437
130histone H2A monoubiquitination (GO:0035518)2.50399113
131cellular response to ethanol (GO:0071361)2.50053214
132histone lysine methylation (GO:0034968)2.49428260
133cardiac ventricle formation (GO:0003211)2.49323143
134negative regulation of neurotransmitter transport (GO:0051589)2.49215902
135regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49076381
136positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49076381
137single strand break repair (GO:0000012)2.47331302
138regulation of histone H3-K9 methylation (GO:0051570)2.47139027
139dendrite morphogenesis (GO:0048813)2.47089394
140L-fucose catabolic process (GO:0042355)2.46827295
141fucose catabolic process (GO:0019317)2.46827295
142L-fucose metabolic process (GO:0042354)2.46827295
143glutamine metabolic process (GO:0006541)2.45932265
144positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45740557
145regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45740557
146cilium organization (GO:0044782)2.45453649
147histone H3-K4 trimethylation (GO:0080182)2.44862914
148phosphorelay signal transduction system (GO:0000160)2.44201621
149membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43475647
150cardiac chamber formation (GO:0003207)2.42256259
151regulation of histone H3-K27 methylation (GO:0061085)2.41728310
152cilium assembly (GO:0042384)2.41511191
153otic vesicle formation (GO:0030916)2.41434322
154resolution of meiotic recombination intermediates (GO:0000712)2.41274374
155regulation of germinal center formation (GO:0002634)2.41160958
156negative regulation of organelle assembly (GO:1902116)2.40545701
157positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.40380742
158cilium morphogenesis (GO:0060271)2.40342536
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39248893
160organelle transport along microtubule (GO:0072384)2.38546287
161regulation of centrosome cycle (GO:0046605)2.38334947
162negative regulation of histone modification (GO:0031057)2.37695119
163mitotic nuclear envelope disassembly (GO:0007077)2.37550803
164synaptic transmission, glutamatergic (GO:0035249)2.36644488
165embryonic hemopoiesis (GO:0035162)2.36271909
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35975158
167positive regulation of developmental pigmentation (GO:0048087)2.35445154
168retinal cone cell development (GO:0046549)2.35247054
169exploration behavior (GO:0035640)2.35121694
170negative regulation of sodium ion transport (GO:0010766)2.33465140
171microtubule depolymerization (GO:0007019)2.32995910
172potassium ion import (GO:0010107)2.32588416
173axon extension (GO:0048675)2.32211910
174gene silencing by RNA (GO:0031047)2.31965754
175glutamine family amino acid catabolic process (GO:0009065)2.30844543
176negative regulation of chromatin modification (GO:1903309)2.30528480
177male meiosis (GO:0007140)2.30202330
178reciprocal DNA recombination (GO:0035825)2.29681832
179reciprocal meiotic recombination (GO:0007131)2.29681832
180detection of light stimulus involved in sensory perception (GO:0050962)2.28797250
181detection of light stimulus involved in visual perception (GO:0050908)2.28797250
182central nervous system neuron axonogenesis (GO:0021955)2.28046325
183regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27694163
184acrosome reaction (GO:0007340)2.27490893
185microtubule organizing center organization (GO:0031023)2.27345689
186positive regulation of growth hormone secretion (GO:0060124)2.26301370
187protein K63-linked deubiquitination (GO:0070536)2.25887075
188seminiferous tubule development (GO:0072520)2.25843101
189cAMP catabolic process (GO:0006198)2.23985958
190tryptophan metabolic process (GO:0006568)2.23413475
191motile cilium assembly (GO:0044458)2.22674188
192activated T cell proliferation (GO:0050798)2.22460417
193regulation of non-canonical Wnt signaling pathway (GO:2000050)2.21902835
194regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.21716074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.54690600
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.37593641
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.49743745
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.20394588
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.91179150
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81437211
7VDR_22108803_ChIP-Seq_LS180_Human2.69232926
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.62942342
9E2F7_22180533_ChIP-Seq_HELA_Human2.58662346
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46589560
11SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.46396039
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36144792
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33572939
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.24432467
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19618881
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12728857
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11187446
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03649854
19EZH2_22144423_ChIP-Seq_EOC_Human2.02723550
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.99085226
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96200018
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95341512
23DROSHA_22980978_ChIP-Seq_HELA_Human1.91614849
24ER_23166858_ChIP-Seq_MCF-7_Human1.84710144
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84500322
26GBX2_23144817_ChIP-Seq_PC3_Human1.84289849
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.79760363
28CBP_20019798_ChIP-Seq_JUKART_Human1.79460452
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79460452
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74903836
31BCAT_22108803_ChIP-Seq_LS180_Human1.73586986
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.71949609
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58277441
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53070601
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52790480
36TP53_16413492_ChIP-PET_HCT116_Human1.51438841
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.51015941
38AR_25329375_ChIP-Seq_VCAP_Human1.50863847
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42952527
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42739826
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42618715
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42618715
43IRF1_19129219_ChIP-ChIP_H3396_Human1.40952311
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37551738
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36907264
46FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35765522
47RUNX2_22187159_ChIP-Seq_PCA_Human1.33986426
48* STAT3_23295773_ChIP-Seq_U87_Human1.33886049
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.31739037
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31574678
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31398741
52SMAD4_21799915_ChIP-Seq_A2780_Human1.30863893
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.30433177
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.30343523
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28671584
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28514674
57TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26030432
58TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25646182
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.25636153
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25518145
61* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24213362
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22849435
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20921238
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20761518
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19424860
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18517363
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18224861
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17999519
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16905537
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.16315435
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.16128452
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15813162
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14803939
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14753398
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14733089
76* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14373715
77AR_19668381_ChIP-Seq_PC3_Human1.14010910
78TAF15_26573619_Chip-Seq_HEK293_Human1.13099884
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13079544
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.12409664
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.11350718
82AR_21572438_ChIP-Seq_LNCaP_Human1.10163289
83RNF2_27304074_Chip-Seq_NSC_Mouse1.09876078
84P53_22387025_ChIP-Seq_ESCs_Mouse1.09212271
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.09202433
86TCF4_23295773_ChIP-Seq_U87_Human1.09150410
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.09037672
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.08934866
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.08575188
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08289336
91RUNX_20019798_ChIP-Seq_JUKART_Human1.08182997
92NANOG_19829295_ChIP-Seq_ESCs_Human1.07390854
93SOX2_19829295_ChIP-Seq_ESCs_Human1.07390854
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07284755
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06709303
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06299049
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06269054
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05429416
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05074366
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.04646455
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04328831
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04034549
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02744262
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02209802
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02059182
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01837700
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01753991
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.01657543
109TBL1_22424771_ChIP-Seq_293T_Human1.01452213
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01325104
111REST_21632747_ChIP-Seq_MESCs_Mouse1.01050242
112* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00711017
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00538636
114* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99707704
115SCL_19346495_ChIP-Seq_HPC-7_Human0.98932974
116KDM2B_26808549_Chip-Seq_REH_Human0.98832294
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98802914
118IGF1R_20145208_ChIP-Seq_DFB_Human0.98733775
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98153317
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98126706
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97895461
122CDX2_22108803_ChIP-Seq_LS180_Human0.97355852
123EWS_26573619_Chip-Seq_HEK293_Human0.96726229
124TP53_22573176_ChIP-Seq_HFKS_Human0.96534960
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95535375
126P300_19829295_ChIP-Seq_ESCs_Human0.95248903
127FUS_26573619_Chip-Seq_HEK293_Human0.94525058
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93938867
129OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93374744
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93341759
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.93184813
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92502262
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92464999
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91679925
135ZNF274_21170338_ChIP-Seq_K562_Hela0.91225384
136AHR_22903824_ChIP-Seq_MCF-7_Human0.91038260
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91015082
138* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90855591
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.88754384
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88273770
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88153889
142DPY_21335234_ChIP-Seq_ESCs_Mouse0.88032569
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.87971165
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87530222
145SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87291167
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.85339444
147KDM2B_26808549_Chip-Seq_K562_Human0.84557978
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.84346240
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.83922208
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.83768611
151* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83412149
152MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81154821
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.79419067
154TCF4_22108803_ChIP-Seq_LS180_Human0.79104653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75918799
2MP0003705_abnormal_hypodermis_morpholog4.96212150
3MP0010307_abnormal_tumor_latency3.57763940
4MP0000569_abnormal_digit_pigmentation3.38897320
5MP0010234_abnormal_vibrissa_follicle3.32883135
6MP0006292_abnormal_olfactory_placode2.95837905
7MP0002735_abnormal_chemical_nociception2.76205936
8MP0003635_abnormal_synaptic_transmissio2.70709548
9MP0004270_analgesia2.46272982
10MP0004185_abnormal_adipocyte_glucose2.43791053
11MP0002638_abnormal_pupillary_reflex2.35520359
12MP0003787_abnormal_imprinting2.20618739
13MP0001968_abnormal_touch/_nociception2.18691363
14MP0004858_abnormal_nervous_system2.10616979
15MP0005174_abnormal_tail_pigmentation2.09789116
16MP0005551_abnormal_eye_electrophysiolog2.02784196
17MP0002063_abnormal_learning/memory/cond2.00477632
18MP0003646_muscle_fatigue1.99995218
19MP0002736_abnormal_nociception_after1.97867867
20MP0005253_abnormal_eye_physiology1.96438133
21MP0003123_paternal_imprinting1.95192905
22MP0002064_seizures1.94027819
23MP0004885_abnormal_endolymph1.91436423
24MP0000015_abnormal_ear_pigmentation1.89581701
25MP0006276_abnormal_autonomic_nervous1.88326180
26MP0009745_abnormal_behavioral_response1.85313118
27MP0002837_dystrophic_cardiac_calcinosis1.85124248
28MP0008877_abnormal_DNA_methylation1.83237437
29MP0008995_early_reproductive_senescence1.81982985
30MP0003633_abnormal_nervous_system1.76038206
31MP0002095_abnormal_skin_pigmentation1.75765740
32MP0009046_muscle_twitch1.75723072
33MP0003880_abnormal_central_pattern1.75717183
34MP0000955_abnormal_spinal_cord1.71665222
35MP0006072_abnormal_retinal_apoptosis1.71113531
36MP0005410_abnormal_fertilization1.69698509
37MP0004145_abnormal_muscle_electrophysio1.68545412
38MP0003690_abnormal_glial_cell1.61659841
39MP0001849_ear_inflammation1.60851861
40MP0001501_abnormal_sleep_pattern1.58012294
41MP0000631_abnormal_neuroendocrine_gland1.57805291
42MP0005076_abnormal_cell_differentiation1.57150544
43MP0004811_abnormal_neuron_physiology1.56193349
44MP0002009_preneoplasia1.54674227
45MP0005666_abnormal_adipose_tissue1.53312145
46MP0001486_abnormal_startle_reflex1.52097598
47MP0010352_gastrointestinal_tract_polyps1.51613577
48MP0009780_abnormal_chondrocyte_physiolo1.51014108
49MP0000778_abnormal_nervous_system1.50093013
50MP0005167_abnormal_blood-brain_barrier1.48104071
51MP0008057_abnormal_DNA_replication1.47047331
52MP0002572_abnormal_emotion/affect_behav1.46524630
53MP0002272_abnormal_nervous_system1.45903827
54MP0003121_genomic_imprinting1.44998198
55MP0008775_abnormal_heart_ventricle1.44542555
56MP0000516_abnormal_urinary_system1.37348320
57MP0005367_renal/urinary_system_phenotyp1.37348320
58MP0003890_abnormal_embryonic-extraembry1.36787156
59MP0003631_nervous_system_phenotype1.35759274
60MP0002734_abnormal_mechanical_nocicepti1.33075594
61MP0004043_abnormal_pH_regulation1.32363147
62MP0000427_abnormal_hair_cycle1.31112639
63MP0001485_abnormal_pinna_reflex1.30188365
64MP0002102_abnormal_ear_morphology1.28310050
65MP0001177_atelectasis1.27849913
66MP0002733_abnormal_thermal_nociception1.27067088
67MP0003111_abnormal_nucleus_morphology1.26052728
68MP0002067_abnormal_sensory_capabilities1.25005863
69MP0003698_abnormal_male_reproductive1.24466584
70MP0001984_abnormal_olfaction1.24453790
71MP0001986_abnormal_taste_sensitivity1.23662339
72MP0001929_abnormal_gametogenesis1.23073676
73MP0004142_abnormal_muscle_tone1.20170089
74MP0002127_abnormal_cardiovascular_syste1.18952824
75MP0005499_abnormal_olfactory_system1.18097605
76MP0005394_taste/olfaction_phenotype1.18097605
77MP0010678_abnormal_skin_adnexa1.17480758
78MP0005623_abnormal_meninges_morphology1.16357775
79MP0008789_abnormal_olfactory_epithelium1.14664254
80MP0005646_abnormal_pituitary_gland1.13423407
81MP0003632_abnormal_nervous_system1.12980255
82MP0005248_abnormal_Harderian_gland1.12469787
83MP0002882_abnormal_neuron_morphology1.10742259
84MP0003950_abnormal_plasma_membrane1.10283439
85MP0004742_abnormal_vestibular_system1.10171325
86MP0009703_decreased_birth_body1.09463625
87MP0002084_abnormal_developmental_patter1.09180547
88MP0002132_abnormal_respiratory_system1.09121191
89MP0001440_abnormal_grooming_behavior1.07915816
90MP0000372_irregular_coat_pigmentation1.07584869
91MP0005645_abnormal_hypothalamus_physiol1.07337389
92MP0003122_maternal_imprinting1.05359614
93MP0004130_abnormal_muscle_cell1.03951257
94MP0010368_abnormal_lymphatic_system1.03053919
95MP0004036_abnormal_muscle_relaxation1.02247355
96MP0001970_abnormal_pain_threshold1.00344117
97MP0001299_abnormal_eye_distance/0.98599872
98MP0002006_tumorigenesis0.98096357
99MP0000013_abnormal_adipose_tissue0.97615553
100MP0002928_abnormal_bile_duct0.97104659
101MP0003718_maternal_effect0.96118264
102MP0001545_abnormal_hematopoietic_system0.95998064
103MP0005397_hematopoietic_system_phenotyp0.95998064
104MP0005375_adipose_tissue_phenotype0.95163499
105MP0003656_abnormal_erythrocyte_physiolo0.95131894
106MP0004510_myositis0.94793133
107MP0002396_abnormal_hematopoietic_system0.93752759
108MP0010094_abnormal_chromosome_stability0.93437222
109MP0003566_abnormal_cell_adhesion0.93385408
110MP0002557_abnormal_social/conspecific_i0.91767597
111MP0000230_abnormal_systemic_arterial0.91647558
112MP0005195_abnormal_posterior_eye0.90333610
113MP0003136_yellow_coat_color0.88676216
114MP0004084_abnormal_cardiac_muscle0.88222237
115MP0003634_abnormal_glial_cell0.88037250
116MP0002210_abnormal_sex_determination0.86994064
117MP0002254_reproductive_system_inflammat0.86992984
118MP0003091_abnormal_cell_migration0.85447033
119MP0002152_abnormal_brain_morphology0.85052902
120MP0002653_abnormal_ependyma_morphology0.84919896
121MP0004484_altered_response_of0.84901516
122MP0001915_intracranial_hemorrhage0.84757530
123MP0000383_abnormal_hair_follicle0.83709065
124MP0008058_abnormal_DNA_repair0.83703250
125MP0009697_abnormal_copulation0.83506722
126MP0002752_abnormal_somatic_nervous0.83397944
127MP0002066_abnormal_motor_capabilities/c0.83201112
128MP0008438_abnormal_cutaneous_collagen0.81269977
129MP0005266_abnormal_metabolism0.81195065
130MP0005275_abnormal_skin_tensile0.80555197
131MP0002086_abnormal_extraembryonic_tissu0.80349858
132MP0000653_abnormal_sex_gland0.80152502
133MP0008770_decreased_survivor_rate0.79960164
134MP0009115_abnormal_fat_cell0.79656988
135MP0005386_behavior/neurological_phenoty0.78950769
136MP0004924_abnormal_behavior0.78950769
137MP0003045_fibrosis0.78553330
138MP0000747_muscle_weakness0.78332789
139MP0002229_neurodegeneration0.78181569
140MP0005391_vision/eye_phenotype0.77056351
141MP0002184_abnormal_innervation0.76804999
142MP0001502_abnormal_circadian_rhythm0.75411697
143MP0002269_muscular_atrophy0.75200683
144MP0001879_abnormal_lymphatic_vessel0.74071459
145MP0002160_abnormal_reproductive_system0.73655214
146MP0005171_absent_coat_pigmentation0.73280628
147MP0004272_abnormal_basement_membrane0.72811787
148MP0003861_abnormal_nervous_system0.71970187
149MP0008874_decreased_physiological_sensi0.71088685
150MP0001764_abnormal_homeostasis0.71033093
151MP0003252_abnormal_bile_duct0.70916509
152MP0004215_abnormal_myocardial_fiber0.70707860
153MP0004808_abnormal_hematopoietic_stem0.70597578
154MP0005395_other_phenotype0.70223269
155MP0001119_abnormal_female_reproductive0.69668399
156MP0006054_spinal_hemorrhage0.68911913
157MP0008961_abnormal_basal_metabolism0.68875275
158MP0003300_gastrointestinal_ulcer0.68346751
159MP0008569_lethality_at_weaning0.67030638
160MP0000920_abnormal_myelination0.67001295
161MP0005085_abnormal_gallbladder_physiolo0.65800524
162MP0002925_abnormal_cardiovascular_devel0.65028277
163MP0001672_abnormal_embryogenesis/_devel0.62902632
164MP0005380_embryogenesis_phenotype0.62902632
165MP0004085_abnormal_heartbeat0.59381392
166MP0005423_abnormal_somatic_nervous0.59359803

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.05024684
2Abnormality of the renal cortex (HP:0011035)3.76964968
3Pancreatic cysts (HP:0001737)3.71120417
4Pancreatic fibrosis (HP:0100732)3.54089909
5Abnormality of the renal medulla (HP:0100957)3.53940522
6Nephronophthisis (HP:0000090)3.53404887
7Chronic hepatic failure (HP:0100626)3.38829038
8Tetraplegia (HP:0002445)3.32600030
9Abnormality of the labia minora (HP:0012880)3.30073221
10True hermaphroditism (HP:0010459)3.27841440
11Increased CSF protein (HP:0002922)3.26825239
12Action tremor (HP:0002345)3.16767531
13Abnormality of the lower motor neuron (HP:0002366)3.13450117
14Medial flaring of the eyebrow (HP:0010747)3.07896589
15Renal cortical cysts (HP:0000803)3.02357385
16Congenital stationary night blindness (HP:0007642)3.00263469
17Molar tooth sign on MRI (HP:0002419)2.93217854
18Abnormality of midbrain morphology (HP:0002418)2.93217854
19Protruding tongue (HP:0010808)2.88264509
20Focal seizures (HP:0007359)2.86885820
21Inappropriate behavior (HP:0000719)2.85750600
22Aqueductal stenosis (HP:0002410)2.81039773
23Nephrogenic diabetes insipidus (HP:0009806)2.76452307
24Postural instability (HP:0002172)2.74419392
25Gaze-evoked nystagmus (HP:0000640)2.73483048
26Gait imbalance (HP:0002141)2.72936881
27Focal motor seizures (HP:0011153)2.71776920
28Macroorchidism (HP:0000053)2.70400955
29Myokymia (HP:0002411)2.67154050
30Poor coordination (HP:0002370)2.67110358
31Achilles tendon contracture (HP:0001771)2.66173676
32Congenital primary aphakia (HP:0007707)2.64197948
33Progressive cerebellar ataxia (HP:0002073)2.64028942
34Hypoplastic iliac wings (HP:0002866)2.63925063
35Abnormality of the ischium (HP:0003174)2.63714917
36Cystic liver disease (HP:0006706)2.59032269
37Abnormality of the Achilles tendon (HP:0005109)2.52985642
38Termporal pattern (HP:0011008)2.51422944
39Insidious onset (HP:0003587)2.51422944
40Hypochromic microcytic anemia (HP:0004840)2.51374119
41Genetic anticipation (HP:0003743)2.48519046
42Poor eye contact (HP:0000817)2.38758893
43Narrow palate (HP:0000189)2.38529124
44Pointed chin (HP:0000307)2.37951725
45Impaired social interactions (HP:0000735)2.37743650
46Abnormal social behavior (HP:0012433)2.37743650
47Broad-based gait (HP:0002136)2.36712703
48Excessive salivation (HP:0003781)2.36338299
49Drooling (HP:0002307)2.36338299
50Thyroiditis (HP:0100646)2.35984707
51Shoulder girdle muscle weakness (HP:0003547)2.35332239
52Absent/shortened dynein arms (HP:0200106)2.31990664
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.31990664
54Pelvic girdle muscle weakness (HP:0003749)2.31957772
55Bile duct proliferation (HP:0001408)2.30615199
56Abnormal biliary tract physiology (HP:0012439)2.30615199
57Enlarged penis (HP:0000040)2.27935413
58Tubulointerstitial abnormality (HP:0001969)2.27666815
59Congenital hepatic fibrosis (HP:0002612)2.27482623
60Hypoplastic ischia (HP:0003175)2.26097900
61Visual hallucinations (HP:0002367)2.25879752
62Urinary urgency (HP:0000012)2.25150795
63Impaired vibration sensation in the lower limbs (HP:0002166)2.25110849
64Hypoplasia of the thymus (HP:0000778)2.23174987
65Febrile seizures (HP:0002373)2.23124546
66Shallow orbits (HP:0000586)2.22946296
67Postaxial foot polydactyly (HP:0001830)2.22518278
68Long toe (HP:0010511)2.18671087
69Genital tract atresia (HP:0001827)2.17677698
70Stomach cancer (HP:0012126)2.15836003
71Impaired smooth pursuit (HP:0007772)2.15528290
72Protruding ear (HP:0000411)2.14858326
73Urinary bladder sphincter dysfunction (HP:0002839)2.13824479
74Obsessive-compulsive behavior (HP:0000722)2.13593959
75Heterotopia (HP:0002282)2.13065127
76Hypopigmentation of the fundus (HP:0007894)2.12822931
77Hypoventilation (HP:0002791)2.11068186
78Abnormality of the musculature of the pelvis (HP:0001469)2.09646452
79Abnormality of the hip-girdle musculature (HP:0001445)2.09646452
80Renovascular hypertension (HP:0100817)2.08989200
81Cerebral aneurysm (HP:0004944)2.08117462
82Intestinal atresia (HP:0011100)2.07374474
83Hypoalphalipoproteinemia (HP:0003233)2.05793783
84Abolished electroretinogram (ERG) (HP:0000550)2.05759859
85Vaginal atresia (HP:0000148)2.04561902
86Papillary thyroid carcinoma (HP:0002895)2.02246684
87Vertebral arch anomaly (HP:0008438)2.01499312
88Abnormal rod and cone electroretinograms (HP:0008323)2.00777653
89Abnormal ciliary motility (HP:0012262)2.00616405
90Lower limb amyotrophy (HP:0007210)2.00315674
91Attenuation of retinal blood vessels (HP:0007843)2.00257839
92Bony spicule pigmentary retinopathy (HP:0007737)1.97663223
93Subacute progressive viral hepatitis (HP:0006572)1.97654217
94Truncal obesity (HP:0001956)1.96765347
95Frequent falls (HP:0002359)1.96100157
96Absent frontal sinuses (HP:0002688)1.95921250
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.94936977
98Tubular atrophy (HP:0000092)1.94493802
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.94335320
100Resting tremor (HP:0002322)1.93738729
101Supranuclear gaze palsy (HP:0000605)1.93634300
102Spastic diplegia (HP:0001264)1.92593876
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92092117
104Hip dysplasia (HP:0001385)1.92070382
105Male pseudohermaphroditism (HP:0000037)1.92039520
106Oligodactyly (hands) (HP:0001180)1.91202503
107Abnormal hair whorl (HP:0010721)1.90505885
108Epileptic encephalopathy (HP:0200134)1.88947692
109Tubulointerstitial nephritis (HP:0001970)1.88762045
110Growth hormone deficiency (HP:0000824)1.88477263
111Acute lymphatic leukemia (HP:0006721)1.87868314
112Slow saccadic eye movements (HP:0000514)1.87710024
113Abnormality of ocular smooth pursuit (HP:0000617)1.87097774
114Deep philtrum (HP:0002002)1.86544077
115Atonic seizures (HP:0010819)1.85350273
116Decreased circulating renin level (HP:0003351)1.85291051
117Generalized tonic-clonic seizures (HP:0002069)1.84479786
118Highly arched eyebrow (HP:0002553)1.84173322
119Abnormality of the corticospinal tract (HP:0002492)1.82148217
120Disinhibition (HP:0000734)1.82112091
121Type II lissencephaly (HP:0007260)1.80985012
122Hemiplegia (HP:0002301)1.78669176
123Anencephaly (HP:0002323)1.77202898
124Sloping forehead (HP:0000340)1.77129825
125Bladder neoplasm (HP:0009725)1.77045173
126Bladder carcinoma (HP:0002862)1.77045173
127Colon cancer (HP:0003003)1.76031253
128Neoplasm of the oral cavity (HP:0100649)1.75353680
129Astigmatism (HP:0000483)1.75274720
130Exotropia (HP:0000577)1.75096745
131Postaxial hand polydactyly (HP:0001162)1.75028898
132Hematochezia (HP:0002573)1.74680272
133Polydipsia (HP:0001959)1.74364411
134Abnormal drinking behavior (HP:0030082)1.74364411
135Generalized hypopigmentation of hair (HP:0011358)1.74134817
136Supernumerary spleens (HP:0009799)1.73524404
137Abnormality of B cell number (HP:0010975)1.72990002
138Poikilocytosis (HP:0004447)1.71201115
139Tented upper lip vermilion (HP:0010804)1.71055717
140Hypoglycemic seizures (HP:0002173)1.70881331
141Abnormality of the pons (HP:0007361)1.70447659
142Severe combined immunodeficiency (HP:0004430)1.68861550
143Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68542617
144Dysmetria (HP:0001310)1.68477603
145Dysdiadochokinesis (HP:0002075)1.68112156
146Absent speech (HP:0001344)1.67187578
147Fair hair (HP:0002286)1.67034013
148Cerebellar dysplasia (HP:0007033)1.65809071
149Bronchomalacia (HP:0002780)1.65276782
150Skull defect (HP:0001362)1.65236620
151Prolonged QT interval (HP:0001657)1.65232516
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64752651
153Centrally nucleated skeletal muscle fibers (HP:0003687)1.64583055
154Prominent nasal bridge (HP:0000426)1.64473134
155Ectopic kidney (HP:0000086)1.64451602
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64267377
157Short 4th metacarpal (HP:0010044)1.64267377
158Ankyloglossia (HP:0010296)1.64242829
159Spastic gait (HP:0002064)1.64222969
160Hyperinsulinemic hypoglycemia (HP:0000825)1.63595651
161Absence seizures (HP:0002121)1.63528910
162Widely spaced teeth (HP:0000687)1.63500119
163Short foot (HP:0001773)1.63459839
164Leiomyosarcoma (HP:0100243)1.63172399
165Uterine leiomyosarcoma (HP:0002891)1.63172399
166Rhabdomyosarcoma (HP:0002859)1.62951014
167Depression (HP:0000716)1.62521859
168Sandal gap (HP:0001852)1.62375587
169High pitched voice (HP:0001620)1.61789079
170Abnormality of DNA repair (HP:0003254)1.61303329
171Volvulus (HP:0002580)1.60845252
172Calf muscle hypertrophy (HP:0008981)1.60764551
173Gastrointestinal carcinoma (HP:0002672)1.60420435
174Malignant gastrointestinal tract tumors (HP:0006749)1.60420435
175Abnormality of chromosome stability (HP:0003220)1.59945406
176Polyuria (HP:0000103)1.59584968
177Acute myeloid leukemia (HP:0004808)1.59518038
178Brushfield spots (HP:0001088)1.59513208
179Narrow forehead (HP:0000341)1.59027310
180Flat occiput (HP:0005469)1.58878325
181Abnormality of nail color (HP:0100643)1.58334805
182Impaired pain sensation (HP:0007328)1.57911556
183Abnormality of pain sensation (HP:0010832)1.57911556
184Transitional cell carcinoma of the bladder (HP:0006740)1.56416815
185Increased connective tissue (HP:0009025)1.55185333
186Scanning speech (HP:0002168)1.53851384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK8.30966333
2WEE15.79773970
3PKN23.33387754
4MAP4K23.19281312
5NUAK12.91132912
6BMPR1B2.74276762
7NTRK32.72960775
8SCYL22.70730356
9TAOK32.43287406
10MAP3K92.37728181
11MAPK132.06214488
12CAMK1D1.88744257
13EPHA41.87935387
14MAP3K41.87885021
15RIPK11.85687589
16PINK11.84821306
17KSR21.79528828
18ACVR1B1.77568598
19CAMK1G1.70253253
20NEK11.66321380
21ADRBK21.63457571
22CASK1.47227924
23OBSCN1.46436680
24MAP3K21.46115208
25ALK1.39077895
26PTK61.37572828
27CDK191.36491387
28PLK41.36236890
29TNIK1.34171446
30RET1.32528428
31DAPK21.31260349
32WNK31.31075690
33CDK121.25213873
34NTRK11.24604427
35PAK61.23494124
36FLT31.23014787
37ERBB21.21843077
38ZAK1.21079777
39PIK3CG1.20395536
40WNK11.19884757
41LMTK21.18819702
42SRPK11.15427747
43CDK31.14525926
44TEC1.13519726
45KSR11.11861083
46CAMKK11.11123619
47IRAK11.09685300
48PKN11.09074611
49MINK11.08881245
50MAP2K41.07439778
51NLK1.05277974
52CDK61.04312728
53SYK0.97601008
54GRK10.94320651
55TGFBR10.93756954
56PTK2B0.93427400
57CSNK1D0.92253927
58ITK0.89923038
59AKT30.87530420
60LATS20.87003663
61BTK0.86292999
62YES10.85873883
63KIT0.84858583
64MAP3K130.84517640
65NTRK20.84427352
66RIPK40.83668097
67PDGFRA0.82398907
68PLK20.81708895
69PDK10.79753393
70FGFR20.76970015
71VRK10.75666840
72INSRR0.74332274
73PIK3CA0.73918139
74CSNK1A1L0.73478295
75BLK0.72760551
76SIK20.71065242
77PDGFRB0.70611947
78STK110.70213942
79WNK40.69172933
80FGFR10.69139076
81LATS10.68685421
82CAMK10.68142448
83FER0.67603963
84CCNB10.66691892
85MARK20.66214165
86MAPK150.65853350
87SGK30.64891006
88TIE10.64670749
89MAPK70.64386376
90CDK80.64292656
91OXSR10.63893597
92CDK50.62862493
93MAP3K80.61920512
94TNK20.60894107
95TLK10.58992884
96PRKCQ0.58479596
97MAPK120.58111361
98BRD40.58091937
99PRKG10.57798166
100PDPK10.57657942
101SGK10.57249440
102EIF2AK30.55727879
103PRKD30.55440467
104CSNK1G10.55013052
105MELK0.54908161
106MAPKAPK50.54571631
107PRKAA20.54171319
108SGK20.52849297
109MAP2K70.52257867
110MARK10.52213682
111ATM0.50446898
112PIM10.50064221
113PAK30.49864138
114CAMK40.48658571
115BRSK20.48493978
116DAPK30.48161231
117EIF2AK20.47998026
118CAMKK20.47946729
119TXK0.47806184
120STK390.47155730
121PRKCH0.46606866
122STK380.45265366
123MAPK100.45205673
124IRAK20.44876758
125RPS6KA30.43998928
126JAK10.43766606
127STK30.43558505
128MAP3K70.42363540
129RPS6KA50.42110733
130PRKCE0.41852615
131GSK3B0.41316668
132TTN0.41315742
133NEK20.40713915
134CSNK1E0.40532061
135PRKCG0.39946360
136GSK3A0.39743983
137MAPK80.39669754
138SGK2230.39507182
139SGK4940.39507182
140CSNK1G20.39051082
141BCR0.39044644
142CSNK1G30.38907913
143FGFR30.38622638
144JAK20.38594925
145RPS6KB10.37815771
146PRKAA10.37726017
147MARK30.37299291
148FRK0.37261166
149ERBB30.37212123
150TRIB30.36688518
151PRKDC0.36545031
152MAPK140.36418448
153MAP2K10.35924612
154CHEK10.35299848
155CDK10.35124967
156PDK20.34605193
157ADRBK10.34090748
158ATR0.34038379
159EGFR0.33976733
160FYN0.33764975
161PHKG10.32760384
162PHKG20.32760384
163CDC42BPA0.31439835
164CDK20.31135194

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.32744687
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.59545814
3ABC transporters_Homo sapiens_hsa020102.24136881
4Fanconi anemia pathway_Homo sapiens_hsa034602.23450969
5Linoleic acid metabolism_Homo sapiens_hsa005912.07208130
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03006345
7Arginine biosynthesis_Homo sapiens_hsa002201.97892245
8Long-term potentiation_Homo sapiens_hsa047201.95842188
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.92047899
10Ether lipid metabolism_Homo sapiens_hsa005651.86203250
11Basal transcription factors_Homo sapiens_hsa030221.80989660
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80926663
13Type II diabetes mellitus_Homo sapiens_hsa049301.74472014
14Nicotine addiction_Homo sapiens_hsa050331.72751658
15Synaptic vesicle cycle_Homo sapiens_hsa047211.71139157
16Glutamatergic synapse_Homo sapiens_hsa047241.67585404
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64801300
18Phototransduction_Homo sapiens_hsa047441.62287523
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59007930
20Circadian entrainment_Homo sapiens_hsa047131.58408524
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53668671
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.52492509
23Butanoate metabolism_Homo sapiens_hsa006501.45884932
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43767617
25GABAergic synapse_Homo sapiens_hsa047271.43631478
26Propanoate metabolism_Homo sapiens_hsa006401.42331852
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35701727
28Ovarian steroidogenesis_Homo sapiens_hsa049131.33290145
29Amphetamine addiction_Homo sapiens_hsa050311.32505632
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31239340
31Homologous recombination_Homo sapiens_hsa034401.30555872
32Estrogen signaling pathway_Homo sapiens_hsa049151.29797410
33Dorso-ventral axis formation_Homo sapiens_hsa043201.28346154
34Olfactory transduction_Homo sapiens_hsa047401.27339770
35RNA degradation_Homo sapiens_hsa030181.26503613
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25732805
37Salivary secretion_Homo sapiens_hsa049701.25270494
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21800085
39Dopaminergic synapse_Homo sapiens_hsa047281.21382319
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20850556
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20307877
42Morphine addiction_Homo sapiens_hsa050321.19677176
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.19498476
44Cholinergic synapse_Homo sapiens_hsa047251.18300901
45Long-term depression_Homo sapiens_hsa047301.16524620
46Glioma_Homo sapiens_hsa052141.16479369
47Insulin secretion_Homo sapiens_hsa049111.15425148
48Circadian rhythm_Homo sapiens_hsa047101.14866951
49Regulation of autophagy_Homo sapiens_hsa041401.13515543
50Gastric acid secretion_Homo sapiens_hsa049711.12264858
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11748273
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09469595
53Lysine degradation_Homo sapiens_hsa003101.09440983
54Selenocompound metabolism_Homo sapiens_hsa004501.09251705
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08573515
56Cocaine addiction_Homo sapiens_hsa050301.06080725
57Renin secretion_Homo sapiens_hsa049241.05251741
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03646239
59Gap junction_Homo sapiens_hsa045401.03281189
60Oocyte meiosis_Homo sapiens_hsa041141.02671193
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02524005
62Glycerolipid metabolism_Homo sapiens_hsa005610.99109130
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.98898646
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.97000276
65ErbB signaling pathway_Homo sapiens_hsa040120.96604477
66Oxytocin signaling pathway_Homo sapiens_hsa049210.96547622
67mTOR signaling pathway_Homo sapiens_hsa041500.92627367
68Endometrial cancer_Homo sapiens_hsa052130.91550047
69Peroxisome_Homo sapiens_hsa041460.89208510
70Retinol metabolism_Homo sapiens_hsa008300.88412814
71Axon guidance_Homo sapiens_hsa043600.88188015
72cAMP signaling pathway_Homo sapiens_hsa040240.88058392
73MicroRNAs in cancer_Homo sapiens_hsa052060.86081068
74GnRH signaling pathway_Homo sapiens_hsa049120.85183195
75Bile secretion_Homo sapiens_hsa049760.84863730
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84232324
77Glucagon signaling pathway_Homo sapiens_hsa049220.84020164
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82975838
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82061765
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.82044998
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80320471
82Adherens junction_Homo sapiens_hsa045200.77189114
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74166272
84Chronic myeloid leukemia_Homo sapiens_hsa052200.73376939
85Dilated cardiomyopathy_Homo sapiens_hsa054140.72893947
86Melanogenesis_Homo sapiens_hsa049160.72663969
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72411320
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72151245
89Primary immunodeficiency_Homo sapiens_hsa053400.71840152
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71750021
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.70216872
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69890795
93Thyroid hormone synthesis_Homo sapiens_hsa049180.69872521
94Insulin resistance_Homo sapiens_hsa049310.69672640
95Colorectal cancer_Homo sapiens_hsa052100.69580964
96Taste transduction_Homo sapiens_hsa047420.68601756
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68009427
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.67718081
99Pancreatic secretion_Homo sapiens_hsa049720.67537825
100Chemical carcinogenesis_Homo sapiens_hsa052040.67479408
101Rap1 signaling pathway_Homo sapiens_hsa040150.66786699
102Alcoholism_Homo sapiens_hsa050340.66120749
103Insulin signaling pathway_Homo sapiens_hsa049100.63937181
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63705433
105Calcium signaling pathway_Homo sapiens_hsa040200.63579773
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63096937
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62503999
108Non-small cell lung cancer_Homo sapiens_hsa052230.61971878
109Prostate cancer_Homo sapiens_hsa052150.61718908
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61548765
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60863863
112Proteoglycans in cancer_Homo sapiens_hsa052050.60772853
113MAPK signaling pathway_Homo sapiens_hsa040100.57915451
114Prion diseases_Homo sapiens_hsa050200.57127787
115Focal adhesion_Homo sapiens_hsa045100.56435391
116Graft-versus-host disease_Homo sapiens_hsa053320.55419009
117Fatty acid biosynthesis_Homo sapiens_hsa000610.54789348
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54566188
119FoxO signaling pathway_Homo sapiens_hsa040680.53910245
120Non-homologous end-joining_Homo sapiens_hsa034500.53764273
121Choline metabolism in cancer_Homo sapiens_hsa052310.53576439
122T cell receptor signaling pathway_Homo sapiens_hsa046600.53226649
123B cell receptor signaling pathway_Homo sapiens_hsa046620.53050193
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52677602
125Platelet activation_Homo sapiens_hsa046110.51766667
126Ras signaling pathway_Homo sapiens_hsa040140.51546218
127Inositol phosphate metabolism_Homo sapiens_hsa005620.51432741
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50954700
129Renal cell carcinoma_Homo sapiens_hsa052110.50779907
130Serotonergic synapse_Homo sapiens_hsa047260.50763792
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50714927
132Tight junction_Homo sapiens_hsa045300.50666598
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.48993365
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48915988
135Tryptophan metabolism_Homo sapiens_hsa003800.48587018
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48518701
137Systemic lupus erythematosus_Homo sapiens_hsa053220.47315664
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47160466
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.46774038
140Arachidonic acid metabolism_Homo sapiens_hsa005900.46731398
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46509971
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45779886
143VEGF signaling pathway_Homo sapiens_hsa043700.45663304
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45537595
145Viral carcinogenesis_Homo sapiens_hsa052030.44571031
146TGF-beta signaling pathway_Homo sapiens_hsa043500.44090679
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44018027
148Thyroid cancer_Homo sapiens_hsa052160.43319451
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42882421
150Bladder cancer_Homo sapiens_hsa052190.41645856
151Prolactin signaling pathway_Homo sapiens_hsa049170.41398107
152p53 signaling pathway_Homo sapiens_hsa041150.41231504
153Melanoma_Homo sapiens_hsa052180.41070310
154Staphylococcus aureus infection_Homo sapiens_hsa051500.40783041
155Hematopoietic cell lineage_Homo sapiens_hsa046400.40507438

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