HMBS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protoporphyrinogen IX biosynthetic process (GO:0006782)9.99028491
2* heme biosynthetic process (GO:0006783)7.95055551
3* porphyrin-containing compound biosynthetic process (GO:0006779)7.43935422
4oxygen transport (GO:0015671)7.11196212
5* tetrapyrrole biosynthetic process (GO:0033014)6.63759662
6gas transport (GO:0015669)6.46293549
7* heme metabolic process (GO:0042168)6.43676598
8* porphyrin-containing compound metabolic process (GO:0006778)6.04998888
9erythrocyte maturation (GO:0043249)5.40970726
10DNA strand elongation involved in DNA replication (GO:0006271)4.74545816
11DNA replication initiation (GO:0006270)4.68961268
12DNA strand elongation (GO:0022616)4.56261602
13telomere maintenance via semi-conservative replication (GO:0032201)4.55184765
14hemoglobin metabolic process (GO:0020027)4.22785513
15* pigment biosynthetic process (GO:0046148)4.18631743
16DNA replication checkpoint (GO:0000076)4.14023395
17regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.03902430
18* tetrapyrrole metabolic process (GO:0033013)4.00862859
19erythrocyte development (GO:0048821)3.95753042
20DNA unwinding involved in DNA replication (GO:0006268)3.87708695
21DNA topological change (GO:0006265)3.85679936
22telomere maintenance via recombination (GO:0000722)3.83585932
23folic acid-containing compound biosynthetic process (GO:0009396)3.81780699
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77830847
25CENP-A containing nucleosome assembly (GO:0034080)3.75413478
26DNA deamination (GO:0045006)3.69176230
27ribosomal small subunit assembly (GO:0000028)3.63600982
28protein localization to kinetochore (GO:0034501)3.62669910
29chromatin remodeling at centromere (GO:0031055)3.59382165
30response to lead ion (GO:0010288)3.58705104
31mitotic metaphase plate congression (GO:0007080)3.56279777
32* pigment metabolic process (GO:0042440)3.55799544
33mitotic recombination (GO:0006312)3.54548804
34kinetochore organization (GO:0051383)3.53673047
35attachment of spindle microtubules to kinetochore (GO:0008608)3.46253986
36protein localization to chromosome, centromeric region (GO:0071459)3.45583899
37deoxyribonucleotide biosynthetic process (GO:0009263)3.45267651
38DNA replication-dependent nucleosome assembly (GO:0006335)3.45063555
39DNA replication-dependent nucleosome organization (GO:0034723)3.45063555
40mitotic sister chromatid segregation (GO:0000070)3.44513317
41formation of translation preinitiation complex (GO:0001731)3.43843067
42telomere maintenance via telomere lengthening (GO:0010833)3.33515113
43IMP biosynthetic process (GO:0006188)3.32994118
44proteasome assembly (GO:0043248)3.31156673
45DNA replication-independent nucleosome assembly (GO:0006336)3.30540465
46DNA replication-independent nucleosome organization (GO:0034724)3.30540465
47mitotic nuclear envelope disassembly (GO:0007077)3.30111459
48folic acid metabolic process (GO:0046655)3.29552925
49one-carbon compound transport (GO:0019755)3.24906372
50nucleobase biosynthetic process (GO:0046112)3.24698181
51kinetochore assembly (GO:0051382)3.18998129
52establishment of integrated proviral latency (GO:0075713)3.18242868
53proline biosynthetic process (GO:0006561)3.17996647
54regulation of translational fidelity (GO:0006450)3.17455710
55response to methylmercury (GO:0051597)3.14465467
56purine nucleobase biosynthetic process (GO:0009113)3.14094338
57mitotic chromosome condensation (GO:0007076)3.13332985
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13244319
59negative regulation of ligase activity (GO:0051352)3.13244319
60protein autoprocessing (GO:0016540)3.12670540
61response to insecticide (GO:0017085)3.12428368
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08490704
63metaphase plate congression (GO:0051310)3.07129521
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.04872266
65DNA ligation (GO:0006266)3.03414647
66nuclear envelope disassembly (GO:0051081)3.02203863
67membrane disassembly (GO:0030397)3.02203863
68regulation of mitochondrial translation (GO:0070129)3.00713760
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99912619
70sister chromatid segregation (GO:0000819)2.99833716
71pseudouridine synthesis (GO:0001522)2.99103346
72viral mRNA export from host cell nucleus (GO:0046784)2.96411142
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95215588
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95187616
752-deoxyribonucleotide biosynthetic process (GO:0009265)2.94715005
76deoxyribose phosphate biosynthetic process (GO:0046385)2.94715005
77histone exchange (GO:0043486)2.94000764
78meiotic chromosome segregation (GO:0045132)2.93656869
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90195504
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89964869
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89964869
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89964869
83GDP-mannose metabolic process (GO:0019673)2.89751042
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89236054
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89236054
86positive regulation of ligase activity (GO:0051351)2.88409893
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88290671
88heme transport (GO:0015886)2.86649190
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86646161
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.86646161
91establishment of chromosome localization (GO:0051303)2.86177562
92viral transcription (GO:0019083)2.85883146
93positive regulation of chromosome segregation (GO:0051984)2.84636517
94nucleobase-containing small molecule interconversion (GO:0015949)2.81866659
95ribosome assembly (GO:0042255)2.81492120
96homocysteine metabolic process (GO:0050667)2.80749167
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.80554675
98very-low-density lipoprotein particle assembly (GO:0034379)2.79979461
99tetrahydrofolate metabolic process (GO:0046653)2.79785148
100translational termination (GO:0006415)2.79635253
101maturation of SSU-rRNA (GO:0030490)2.77881104
102chromosome segregation (GO:0007059)2.77032491
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76710323
104peptidyl-arginine omega-N-methylation (GO:0035247)2.76203901
105erythrocyte differentiation (GO:0030218)2.75029233
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74255644
107translational elongation (GO:0006414)2.73849204
108pteridine-containing compound biosynthetic process (GO:0042559)2.72175604
109transcription-coupled nucleotide-excision repair (GO:0006283)2.71806730
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.71682374
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70577227
112energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70427454
113ATP synthesis coupled proton transport (GO:0015986)2.70427454
114regulation of spindle organization (GO:0090224)2.70396340
115IMP metabolic process (GO:0046040)2.70142154
116cell cycle G1/S phase transition (GO:0044843)2.69974896
117G1/S transition of mitotic cell cycle (GO:0000082)2.69974896
118iron-sulfur cluster assembly (GO:0016226)2.69873764
119metallo-sulfur cluster assembly (GO:0031163)2.69873764
120hydrogen peroxide catabolic process (GO:0042744)2.69527528
121tRNA aminoacylation for protein translation (GO:0006418)2.69418469
122protein targeting to mitochondrion (GO:0006626)2.68773422
123ribosome biogenesis (GO:0042254)2.67344919
124glycine metabolic process (GO:0006544)2.66024840
125mitochondrial RNA metabolic process (GO:0000959)2.65405482
126rRNA modification (GO:0000154)2.65025759
127* cofactor biosynthetic process (GO:0051188)2.63224834
128purine-containing compound salvage (GO:0043101)2.62870782
129chromatin assembly or disassembly (GO:0006333)2.62361836
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.59900824
131translational initiation (GO:0006413)2.59432137
132spliceosomal snRNP assembly (GO:0000387)2.57638480
133pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.57078057
134SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56198138
135lysine metabolic process (GO:0006553)2.56013450
136lysine catabolic process (GO:0006554)2.56013450
137folic acid-containing compound metabolic process (GO:0006760)2.55422677
138telomere organization (GO:0032200)2.54195617
139* protoporphyrinogen IX metabolic process (GO:0046501)10.6024587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.10500039
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.05154745
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97436157
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.58354744
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47439186
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14117676
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00672587
8GATA1_22025678_ChIP-Seq_K562_Human2.73638291
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64629263
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63401330
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.59711853
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59023791
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.56758481
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48807435
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.47746064
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44068882
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24072527
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21180063
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11910764
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11863542
21AR_21909140_ChIP-Seq_LNCAP_Human2.09569898
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08796507
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07050664
24VDR_23849224_ChIP-Seq_CD4+_Human2.00746532
25* XRN2_22483619_ChIP-Seq_HELA_Human1.94253646
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92925427
27DCP1A_22483619_ChIP-Seq_HELA_Human1.92351403
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.90613626
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82251664
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82187582
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81778201
32FOXP3_21729870_ChIP-Seq_TREG_Human1.77798922
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.73854973
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72278913
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68950444
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67886076
37* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67839906
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65535594
39* GABP_19822575_ChIP-Seq_HepG2_Human1.65332144
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63754660
41* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56823347
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53869491
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49723666
44* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49684791
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45213808
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43651082
47* GATA1_19941827_ChIP-Seq_MEL_Mouse1.43529789
48* TTF2_22483619_ChIP-Seq_HELA_Human1.41950390
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.41278709
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41057664
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40506114
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37677137
53* GATA1_19941826_ChIP-Seq_K562_Human1.36923745
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35832587
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35678036
56* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34870185
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32701357
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32304182
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31281401
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31168301
61MYC_22102868_ChIP-Seq_BL_Human1.30379544
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30083157
63NCOR1_26117541_ChIP-Seq_K562_Human1.30042659
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29901045
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28918276
66* KDM5A_27292631_Chip-Seq_BREAST_Human1.26108038
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25753384
68CIITA_25753668_ChIP-Seq_RAJI_Human1.24750582
69* ELK1_19687146_ChIP-ChIP_HELA_Human1.20897934
70ZNF263_19887448_ChIP-Seq_K562_Human1.20152638
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19445745
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19347538
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16595962
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15657935
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13274179
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13196102
77SCL_19346495_ChIP-Seq_HPC-7_Human1.12585623
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12249933
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.09164662
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08135115
81TFEB_21752829_ChIP-Seq_HELA_Human1.07969585
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06914530
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05133441
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04084799
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03570435
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03250159
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02097807
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02005494
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00901246
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00896444
91VDR_21846776_ChIP-Seq_THP-1_Human1.00044693
92* GATA2_19941826_ChIP-Seq_K562_Human0.99312925
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97335607
94FOXP1_21924763_ChIP-Seq_HESCs_Human0.96938745
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96401091
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96349723
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95943589
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95771604
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92814775
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92809678
101* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89191555
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87477922
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83591531
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.83426541
105* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81778225
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81692872
107MYC_18940864_ChIP-ChIP_HL60_Human0.80881024
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.79870510
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79671131
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79496372
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78285315
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.78117181
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76600178
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76515678
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75941977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo8.19288876
2* MP0004147_increased_porphyrin_level5.19111825
3MP0003693_abnormal_embryo_hatching4.24218464
4MP0003111_abnormal_nucleus_morphology4.11797201
5MP0010094_abnormal_chromosome_stability3.71383910
6MP0003806_abnormal_nucleotide_metabolis3.43020776
7MP0004957_abnormal_blastocyst_morpholog3.22435941
8MP0003077_abnormal_cell_cycle3.16963132
9MP0008057_abnormal_DNA_replication2.83604254
10MP0002139_abnormal_hepatobiliary_system2.58529910
11MP0008995_early_reproductive_senescence2.57593123
12MP0008058_abnormal_DNA_repair2.48072960
13MP0003186_abnormal_redox_activity2.26098155
14MP0006054_spinal_hemorrhage2.18213409
15MP0006036_abnormal_mitochondrial_physio2.14792579
16MP0005083_abnormal_biliary_tract2.12561938
17MP0001545_abnormal_hematopoietic_system2.11620092
18MP0005397_hematopoietic_system_phenotyp2.11620092
19MP0002396_abnormal_hematopoietic_system2.04735822
20MP0005360_urolithiasis1.98052121
21MP0005085_abnormal_gallbladder_physiolo1.96057687
22MP0001529_abnormal_vocalization1.92559757
23MP0005636_abnormal_mineral_homeostasis1.86529268
24MP0008007_abnormal_cellular_replicative1.82888756
25MP0000490_abnormal_crypts_of1.75848719
26MP0002132_abnormal_respiratory_system1.70705644
27MP0008932_abnormal_embryonic_tissue1.67818627
28MP0005365_abnormal_bile_salt1.57559540
29MP0009278_abnormal_bone_marrow1.56656561
30MP0001730_embryonic_growth_arrest1.51209872
31MP0000350_abnormal_cell_proliferation1.50161099
32MP0010307_abnormal_tumor_latency1.49129213
33MP0001764_abnormal_homeostasis1.44407997
34MP0001661_extended_life_span1.37238816
35MP0000372_irregular_coat_pigmentation1.32274431
36MP0009333_abnormal_splenocyte_physiolog1.28799297
37MP0002095_abnormal_skin_pigmentation1.28600109
38MP0000313_abnormal_cell_death1.25367732
39MP0003718_maternal_effect1.22877531
40MP0003786_premature_aging1.19573208
41MP0005171_absent_coat_pigmentation1.19412850
42MP0003123_paternal_imprinting1.19123850
43* MP0002080_prenatal_lethality1.18414775
44MP0002019_abnormal_tumor_incidence1.17552916
45MP0009840_abnormal_foam_cell1.16311898
46MP0006035_abnormal_mitochondrial_morpho1.15034615
47MP0000609_abnormal_liver_physiology1.14702121
48MP0001697_abnormal_embryo_size1.13749228
49MP0000689_abnormal_spleen_morphology1.10275414
50MP0005451_abnormal_body_composition1.09363160
51MP0002398_abnormal_bone_marrow1.08621177
52MP0002722_abnormal_immune_system1.07281707
53MP0008875_abnormal_xenobiotic_pharmacok1.06853364
54MP0000598_abnormal_liver_morphology1.05140898
55MP0001672_abnormal_embryogenesis/_devel1.01974774
56MP0005380_embryogenesis_phenotype1.01974774
57MP0000358_abnormal_cell_content/1.01793274
58MP0005319_abnormal_enzyme/_coenzyme1.00024001
59MP0010352_gastrointestinal_tract_polyps0.98144648
60MP0002086_abnormal_extraembryonic_tissu0.97213900
61MP0009053_abnormal_anal_canal0.96239333
62MP0003984_embryonic_growth_retardation0.94872281
63MP0005501_abnormal_skin_physiology0.94723245
64MP0003567_abnormal_fetal_cardiomyocyte0.94399387
65MP0004185_abnormal_adipocyte_glucose0.93890211
66MP0002429_abnormal_blood_cell0.92748872
67MP0010329_abnormal_lipoprotein_level0.92573225
68MP0002088_abnormal_embryonic_growth/wei0.91542808
69MP0008775_abnormal_heart_ventricle0.88871561
70MP0004145_abnormal_muscle_electrophysio0.88122413
71MP0005075_abnormal_melanosome_morpholog0.87044342
72MP0005076_abnormal_cell_differentiation0.85375422
73MP0005464_abnormal_platelet_physiology0.84380572
74MP0005266_abnormal_metabolism0.83199078
75MP0009931_abnormal_skin_appearance0.82417284
76MP0005377_hearing/vestibular/ear_phenot0.81107882
77MP0003878_abnormal_ear_physiology0.81107882
78MP0001666_abnormal_nutrient_absorption0.80316241
79MP0002938_white_spotting0.80147274
80MP0004197_abnormal_fetal_growth/weight/0.78789499
81MP0005332_abnormal_amino_acid0.78367185
82MP0004808_abnormal_hematopoietic_stem0.78334043
83MP0005376_homeostasis/metabolism_phenot0.73421148
84MP0008789_abnormal_olfactory_epithelium0.69987240
85MP0002084_abnormal_developmental_patter0.69718275
86MP0005584_abnormal_enzyme/coenzyme_acti0.69528808
87MP0008872_abnormal_physiological_respon0.68991514
88* MP0009643_abnormal_urine_homeostasis0.68590788
89MP0009697_abnormal_copulation0.67964081
90MP0001243_abnormal_dermal_layer0.67932813
91MP0000653_abnormal_sex_gland0.67799703
92MP0000703_abnormal_thymus_morphology0.66904779
93MP0009764_decreased_sensitivity_to0.66453546
94MP0009672_abnormal_birth_weight0.65937577
95MP0006292_abnormal_olfactory_placode0.65235537
96MP0008770_decreased_survivor_rate0.64904645
97MP0009763_increased_sensitivity_to0.64298653
98MP0008877_abnormal_DNA_methylation0.64161086
99MP0004233_abnormal_muscle_weight0.63915503
100MP0003315_abnormal_perineum_morphology0.62890865
101MP0000858_altered_metastatic_potential0.62659087
102MP0002085_abnormal_embryonic_tissue0.62562412
103MP0005408_hypopigmentation0.62435013
104MP0005384_cellular_phenotype0.62341409
105MP0009765_abnormal_xenobiotic_induced0.62303067
106MP0000747_muscle_weakness0.61542358
107MP0001727_abnormal_embryo_implantation0.61276688
108MP0004264_abnormal_extraembryonic_tissu0.61101805
109MP0008260_abnormal_autophagy0.60706612
110MP0003221_abnormal_cardiomyocyte_apopto0.59772076
111MP0001881_abnormal_mammary_gland0.59610872
112MP0001853_heart_inflammation0.58812415
113MP0008469_abnormal_protein_level0.58770777
114MP0003191_abnormal_cellular_cholesterol0.58637156
115MP0003698_abnormal_male_reproductive0.58532146
116MP0003699_abnormal_female_reproductive0.57696739
117MP0000015_abnormal_ear_pigmentation0.57053453
118MP0005389_reproductive_system_phenotype0.57047597
119MP0005220_abnormal_exocrine_pancreas0.56564404
120MP0000685_abnormal_immune_system0.55760083
121MP0005330_cardiomyopathy0.55187432
122MP0002210_abnormal_sex_determination0.54875806
123MP0002653_abnormal_ependyma_morphology0.54497552
124MP0002160_abnormal_reproductive_system0.54445528
125MP0003252_abnormal_bile_duct0.54291123
126MP0009703_decreased_birth_body0.53387640
127MP0001145_abnormal_male_reproductive0.53238919
128MP0004215_abnormal_myocardial_fiber0.51924036
129MP0005621_abnormal_cell_physiology0.51797385
130MP0002161_abnormal_fertility/fecundity0.51387864
131MP0002138_abnormal_hepatobiliary_system0.50840388
132MP0003890_abnormal_embryonic-extraembry0.50737747
133MP0000477_abnormal_intestine_morphology0.49351926
134MP0001929_abnormal_gametogenesis0.48914179

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.82775230
2Hypochromic microcytic anemia (HP:0004840)6.60765931
3Acanthocytosis (HP:0001927)6.33347372
4Reticulocytosis (HP:0001923)6.15222994
5Abnormal hemoglobin (HP:0011902)5.58319921
6Abnormal number of erythroid precursors (HP:0012131)5.42676765
7Abnormality of cells of the erythroid lineage (HP:0012130)5.14060622
8Abnormality of reticulocytes (HP:0004312)4.90287309
9Hyperbilirubinemia (HP:0002904)4.88995005
10Cholelithiasis (HP:0001081)4.83957405
11Birth length less than 3rd percentile (HP:0003561)4.62904664
12Abnormal gallbladder morphology (HP:0012437)4.40063328
13Hypochromic anemia (HP:0001931)3.68007589
14Microcytic anemia (HP:0001935)3.59632557
15Cutaneous photosensitivity (HP:0000992)3.46908568
16Increased serum ferritin (HP:0003281)3.24956708
17Increased serum pyruvate (HP:0003542)3.16420728
18Abnormality of glycolysis (HP:0004366)3.14692629
19Polycythemia (HP:0001901)3.12243116
20Abnormality of the gallbladder (HP:0005264)3.10888735
21Acute necrotizing encephalopathy (HP:0006965)3.01627730
22Cholecystitis (HP:0001082)3.00844565
23Abnormal gallbladder physiology (HP:0012438)3.00844565
24Abnormal mitochondria in muscle tissue (HP:0008316)2.98616984
25Abnormality of iron homeostasis (HP:0011031)2.98097493
26Osteomalacia (HP:0002749)2.96388380
27Macrocytic anemia (HP:0001972)2.88440205
28Breast hypoplasia (HP:0003187)2.85980127
29Abnormality of transition element cation homeostasis (HP:0011030)2.83544611
30Petechiae (HP:0000967)2.80691707
31Homocystinuria (HP:0002156)2.74826194
32Abnormality of homocysteine metabolism (HP:0010919)2.74826194
33Reticulocytopenia (HP:0001896)2.68179424
34Oral leukoplakia (HP:0002745)2.67273382
35Mitochondrial inheritance (HP:0001427)2.62742563
36Pallor (HP:0000980)2.59654565
37Microvesicular hepatic steatosis (HP:0001414)2.57705957
38* Paralysis (HP:0003470)2.48092567
39Nonimmune hydrops fetalis (HP:0001790)2.45931326
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39621634
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39621634
42Aplastic anemia (HP:0001915)2.39252091
43Multiple enchondromatosis (HP:0005701)2.37884599
44Abnormality of pyrimidine metabolism (HP:0004353)2.35940098
45Cerebral palsy (HP:0100021)2.31361478
46Hypoglycemic coma (HP:0001325)2.30182410
47Progressive macrocephaly (HP:0004481)2.28713981
48Hypobetalipoproteinemia (HP:0003563)2.27928249
49Increased serum lactate (HP:0002151)2.26229910
50Short middle phalanx of the 5th finger (HP:0004220)2.24935211
51Toxemia of pregnancy (HP:0100603)2.24821558
52Degeneration of anterior horn cells (HP:0002398)2.21418829
53Abnormality of the anterior horn cell (HP:0006802)2.21418829
54Hypoparathyroidism (HP:0000829)2.13039417
55Increased hepatocellular lipid droplets (HP:0006565)2.09417407
56Progressive muscle weakness (HP:0003323)2.08979682
57Increased intramyocellular lipid droplets (HP:0012240)2.07705777
58Chromsome breakage (HP:0040012)2.04418234
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02748289
60Lipid accumulation in hepatocytes (HP:0006561)2.01358801
61Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01297325
62Hepatic necrosis (HP:0002605)2.00656201
63Exercise intolerance (HP:0003546)2.00457418
64* Abnormality of the heme biosynthetic pathway (HP:0010472)11.3879408
65Pancreatic islet-cell hyperplasia (HP:0004510)1.97042908
66Microretrognathia (HP:0000308)1.95129394
67* Diaphragmatic weakness (HP:0009113)1.94728977
68Patellar aplasia (HP:0006443)1.94405352
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93441314
70Increased muscle lipid content (HP:0009058)1.93117420
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.92377898
72Small intestinal stenosis (HP:0012848)1.89445107
73Duodenal stenosis (HP:0100867)1.89445107
74Delusions (HP:0000746)1.89444348
75Selective tooth agenesis (HP:0001592)1.88257013
76Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87984590
77Prolonged bleeding time (HP:0003010)1.87493726
78Metabolic acidosis (HP:0001942)1.86751937
79Myopathic facies (HP:0002058)1.85231817
80Rough bone trabeculation (HP:0100670)1.83952464
81Cerebral hypomyelination (HP:0006808)1.81849949
82Abnormality of chromosome stability (HP:0003220)1.80615754
83Reduced antithrombin III activity (HP:0001976)1.80556968
84Hepatocellular necrosis (HP:0001404)1.80506844
85Prolonged partial thromboplastin time (HP:0003645)1.79141040
86Aplasia/Hypoplasia of the patella (HP:0006498)1.78679703
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78308868
88Abnormality of sulfur amino acid metabolism (HP:0004339)1.78245306
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78210320
90Meckel diverticulum (HP:0002245)1.78125380
91Generalized hyperpigmentation (HP:0007440)1.77114744
92Urticaria (HP:0001025)1.77019302
93Respiratory difficulties (HP:0002880)1.75871447
94Renal Fanconi syndrome (HP:0001994)1.75826798
95Abnormality of the fetal cardiovascular system (HP:0010948)1.75408712
96Abnormal umbilical cord blood vessels (HP:0011403)1.75408712
97Single umbilical artery (HP:0001195)1.75408712
98Intrahepatic cholestasis (HP:0001406)1.74993732
99* Hepatocellular carcinoma (HP:0001402)1.74959937
100Hyperammonemia (HP:0001987)1.73678633
101Truncus arteriosus (HP:0001660)1.73523783
102Abnormality of the preputium (HP:0100587)1.73111378
103Amaurosis fugax (HP:0100576)1.72129133
104Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72037053
105Abnormal spermatogenesis (HP:0008669)1.70574610
106Pancytopenia (HP:0001876)1.69218902
107Myelodysplasia (HP:0002863)1.69036443
108Abnormality of the ileum (HP:0001549)1.68650506
109Epistaxis (HP:0000421)1.68334578
110Lactic acidosis (HP:0003128)1.67258296
111Increased CSF lactate (HP:0002490)1.65675142
112Carpal bone hypoplasia (HP:0001498)1.65272907
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64915765
114Abnormal protein N-linked glycosylation (HP:0012347)1.64915765
115Abnormal protein glycosylation (HP:0012346)1.64915765
116Abnormal glycosylation (HP:0012345)1.64915765
117Confusion (HP:0001289)1.64026989
118Impulsivity (HP:0100710)1.63313949
119Abnormality of alanine metabolism (HP:0010916)1.62510140
120Hyperalaninemia (HP:0003348)1.62510140
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62510140
122Abnormality of serum amino acid levels (HP:0003112)1.61864211
123Duplicated collecting system (HP:0000081)1.61238481
124Ragged-red muscle fibers (HP:0003200)1.60517762
125Hyperthyroidism (HP:0000836)1.60153516
126Abnormality of the umbilical cord (HP:0010881)1.60011653
127Orthostatic hypotension (HP:0001278)1.59883469
128Abnormal lung lobation (HP:0002101)1.59562540
129Squamous cell carcinoma (HP:0002860)1.58891411
130Acute encephalopathy (HP:0006846)1.58803510
131Basal cell carcinoma (HP:0002671)1.58603136
132Onycholysis (HP:0001806)1.57944220
133Hypolipoproteinemia (HP:0010981)1.57855302
134Secondary amenorrhea (HP:0000869)1.57313808
135Hypopigmented skin patches (HP:0001053)1.56565688
136Cerebral edema (HP:0002181)1.56441432
137Hypoplasia of the pons (HP:0012110)1.56067125
138Type I transferrin isoform profile (HP:0003642)1.55753659
139Bone marrow hypocellularity (HP:0005528)1.55687318
140Megaloblastic anemia (HP:0001889)1.55617599
141Respiratory failure (HP:0002878)1.55433199
142Abnormality of the duodenum (HP:0002246)1.54797098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.76263890
2BUB14.38306857
3VRK23.83504602
4CDC73.83388934
5WEE13.25423514
6NME23.12334223
7TLK12.62415641
8VRK12.56129373
9BRSK22.48159822
10BRSK12.47448151
11NEK22.43138684
12STK162.23185683
13NEK12.14372190
14STK41.99411009
15ZAK1.87099705
16DYRK31.85818502
17BCKDK1.85141080
18TTK1.84416771
19PLK11.68474575
20AURKB1.68407065
21EIF2AK31.65019904
22SCYL21.63045305
23AURKA1.62184993
24SRPK11.59186963
25FLT31.57647978
26SMG11.56873539
27PRPF4B1.52898647
28STK101.51533162
29PLK41.46568252
30MAP3K81.35384253
31BMX1.33516736
32ATR1.31616846
33PIM11.27804522
34ACVR1B1.22633342
35CDK41.22503360
36MAP3K111.22289881
37CHEK21.21204734
38KDR1.20299721
39MST41.19522100
40CDK71.17505129
41PDK21.15229913
42MAP3K101.13461067
43RPS6KA41.11320002
44CCNB11.07697350
45TESK21.07145773
46PLK31.06459561
47MAP2K31.05818135
48RPS6KB21.04543530
49MAPK110.98679894
50PIM20.95579324
51CHEK10.92213101
52EEF2K0.87378594
53TAOK10.87060136
54IRAK40.86395220
55TAF10.85540731
56PBK0.85021438
57NUAK10.84099459
58ABL20.83663513
59CDK120.83508582
60MAPKAPK30.83194445
61PKN20.78634297
62RPS6KA50.75441165
63TRPM70.74940393
64ATM0.74741039
65EIF2AK20.74080575
66PASK0.71472266
67RAF10.68777185
68BRAF0.67126073
69TSSK60.66054552
70CSNK2A10.63971190
71DAPK10.63460471
72CDK60.61892052
73NME10.59593306
74IRAK30.59434256
75GRK60.59117621
76CDK20.56250406
77MAP3K30.56216623
78MAP2K10.53557157
79CSNK2A20.53214339
80MKNK10.52062158
81ICK0.51518933
82MAP4K10.51203144
83MARK30.50490104
84MELK0.49259712
85PAK10.48692815
86PRKCI0.45317463
87NEK90.45264179
88TYK20.45150877
89TRIB30.44878601
90CDK10.44303563
91MAPKAPK20.43640285
92LRRK20.42744520
93CDK90.41514032
94TAOK20.40264115
95PINK10.39475260
96RIPK40.39152368
97CDK80.38836101
98INSRR0.38330165
99CLK10.35124171
100JAK20.34862968
101LYN0.32930521
102PAK40.32884406
103MUSK0.31546000
104STK30.30854624
105MAPKAPK50.30336767
106ILK0.29668263
107RPS6KC10.29001464
108RPS6KL10.29001464
109MAP3K50.28583914
110JAK30.28406720
111AKT10.28241966
112RPS6KA60.28049298
113AKT20.27954292
114SYK0.27474910
115TGFBR20.27285626
116ZAP700.26499327
117ARAF0.26467978
118ALK0.26290196
119PRKDC0.26280455
120ERN10.25812787
121TGFBR10.25048555
122CDK190.25037841
123MKNK20.23991502
124DYRK20.23748699
125MTOR0.23304114
126WNK10.23012757
127STK240.22973548
128CDK11A0.17979052
129MAPK140.15116728

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74002498
2* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.45375340
3Mismatch repair_Homo sapiens_hsa034303.34857629
4Vitamin B6 metabolism_Homo sapiens_hsa007502.72552520
5Proteasome_Homo sapiens_hsa030502.71800214
6Ribosome_Homo sapiens_hsa030102.71028360
7One carbon pool by folate_Homo sapiens_hsa006702.54949321
8Base excision repair_Homo sapiens_hsa034102.50011914
9Nucleotide excision repair_Homo sapiens_hsa034202.27159663
10Cell cycle_Homo sapiens_hsa041102.24081593
11Homologous recombination_Homo sapiens_hsa034402.21177840
12Pyrimidine metabolism_Homo sapiens_hsa002402.20648367
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19156548
14Systemic lupus erythematosus_Homo sapiens_hsa053222.13845262
15Spliceosome_Homo sapiens_hsa030402.09534757
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06113982
17RNA transport_Homo sapiens_hsa030132.03590674
18RNA polymerase_Homo sapiens_hsa030202.02036957
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82537002
20Sulfur relay system_Homo sapiens_hsa041221.79681923
21Selenocompound metabolism_Homo sapiens_hsa004501.63397387
22Fanconi anemia pathway_Homo sapiens_hsa034601.53783556
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50603981
24Non-homologous end-joining_Homo sapiens_hsa034501.49129993
25Folate biosynthesis_Homo sapiens_hsa007901.45627748
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44043948
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.40925654
28Glutathione metabolism_Homo sapiens_hsa004801.35621153
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.32334877
30Fatty acid elongation_Homo sapiens_hsa000621.31058867
31p53 signaling pathway_Homo sapiens_hsa041151.27707344
32Biosynthesis of amino acids_Homo sapiens_hsa012301.20224934
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19813388
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18215106
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13971134
36RNA degradation_Homo sapiens_hsa030181.13544784
37Steroid biosynthesis_Homo sapiens_hsa001001.12543975
38Purine metabolism_Homo sapiens_hsa002301.08987004
39Carbon metabolism_Homo sapiens_hsa012001.08069357
40Pentose phosphate pathway_Homo sapiens_hsa000301.03043323
41Basal transcription factors_Homo sapiens_hsa030221.02066807
42Caffeine metabolism_Homo sapiens_hsa002321.00377449
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.96997420
44Pyruvate metabolism_Homo sapiens_hsa006200.96462059
45Alzheimers disease_Homo sapiens_hsa050100.94788648
46Parkinsons disease_Homo sapiens_hsa050120.92884751
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.90533156
48Protein export_Homo sapiens_hsa030600.89137999
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88441819
50Fatty acid degradation_Homo sapiens_hsa000710.83607016
51Nitrogen metabolism_Homo sapiens_hsa009100.82591283
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82475350
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78648716
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77777557
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71618345
56Huntingtons disease_Homo sapiens_hsa050160.70724101
57mRNA surveillance pathway_Homo sapiens_hsa030150.70568789
58Sulfur metabolism_Homo sapiens_hsa009200.70414633
59ABC transporters_Homo sapiens_hsa020100.70348612
60Collecting duct acid secretion_Homo sapiens_hsa049660.69083109
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68765114
62Alcoholism_Homo sapiens_hsa050340.68735470
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68723788
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68271140
65Peroxisome_Homo sapiens_hsa041460.67402580
66Viral carcinogenesis_Homo sapiens_hsa052030.67306007
67beta-Alanine metabolism_Homo sapiens_hsa004100.65866658
68Propanoate metabolism_Homo sapiens_hsa006400.64444378
69Complement and coagulation cascades_Homo sapiens_hsa046100.64267090
70* Metabolic pathways_Homo sapiens_hsa011000.62866509
71Tryptophan metabolism_Homo sapiens_hsa003800.62560388
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61184034
73Chemical carcinogenesis_Homo sapiens_hsa052040.59000115
74Oxidative phosphorylation_Homo sapiens_hsa001900.58409028
75Herpes simplex infection_Homo sapiens_hsa051680.57931883
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57903951
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56544488
78Arginine and proline metabolism_Homo sapiens_hsa003300.55370799
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54791491
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54462292
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53950056
82Epstein-Barr virus infection_Homo sapiens_hsa051690.51386236
83Regulation of autophagy_Homo sapiens_hsa041400.48342518
84Fat digestion and absorption_Homo sapiens_hsa049750.47263473
85Arginine biosynthesis_Homo sapiens_hsa002200.46871890
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45178476
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.44578466
88Galactose metabolism_Homo sapiens_hsa000520.42636598
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42431467
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41843913
91Hematopoietic cell lineage_Homo sapiens_hsa046400.40997807
92Fructose and mannose metabolism_Homo sapiens_hsa000510.40756250
93Malaria_Homo sapiens_hsa051440.40667532
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39609695
95Oocyte meiosis_Homo sapiens_hsa041140.39479143
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.38899298
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38117809
98Vitamin digestion and absorption_Homo sapiens_hsa049770.37377920
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37192635
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34260582
101Tyrosine metabolism_Homo sapiens_hsa003500.33056318
102Phenylalanine metabolism_Homo sapiens_hsa003600.32249710
103Apoptosis_Homo sapiens_hsa042100.31796664
104Fatty acid metabolism_Homo sapiens_hsa012120.30999863
105N-Glycan biosynthesis_Homo sapiens_hsa005100.29671510
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29585925
107Lysine degradation_Homo sapiens_hsa003100.28380452
108Bladder cancer_Homo sapiens_hsa052190.28235201
109Retinol metabolism_Homo sapiens_hsa008300.27229298
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25873692
111Thyroid cancer_Homo sapiens_hsa052160.25592375
112Butanoate metabolism_Homo sapiens_hsa006500.25368798
113Antigen processing and presentation_Homo sapiens_hsa046120.24934653
114PPAR signaling pathway_Homo sapiens_hsa033200.24462411
115Histidine metabolism_Homo sapiens_hsa003400.24068308
116Legionellosis_Homo sapiens_hsa051340.23944672
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23271267
118Cardiac muscle contraction_Homo sapiens_hsa042600.19400383
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18990352
120Chronic myeloid leukemia_Homo sapiens_hsa052200.17226209
121Non-small cell lung cancer_Homo sapiens_hsa052230.17131083
122HTLV-I infection_Homo sapiens_hsa051660.15984198
123Pancreatic cancer_Homo sapiens_hsa052120.15621032
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12925783

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