HMCES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.36839568
2somatic hypermutation of immunoglobulin genes (GO:0016446)5.11910991
3somatic diversification of immune receptors via somatic mutation (GO:0002566)5.11910991
4attachment of spindle microtubules to kinetochore (GO:0008608)4.94295974
5DNA replication initiation (GO:0006270)4.92183874
6DNA strand elongation involved in DNA replication (GO:0006271)4.91530555
7protein localization to kinetochore (GO:0034501)4.90793521
8DNA strand elongation (GO:0022616)4.68843029
9metaphase plate congression (GO:0051310)4.66089210
10telomere maintenance via semi-conservative replication (GO:0032201)4.65512026
11mitotic chromosome condensation (GO:0007076)4.55799336
12DNA replication checkpoint (GO:0000076)4.43974882
13mitotic sister chromatid segregation (GO:0000070)4.35667021
14folic acid-containing compound biosynthetic process (GO:0009396)4.28801172
15chromatin remodeling at centromere (GO:0031055)4.25160093
16protein localization to chromosome, centromeric region (GO:0071459)4.24065076
17establishment of chromosome localization (GO:0051303)4.23754485
18telomere maintenance via recombination (GO:0000722)4.21638806
19CENP-A containing nucleosome assembly (GO:0034080)4.21407896
20protein K6-linked ubiquitination (GO:0085020)4.18857120
21DNA replication-dependent nucleosome organization (GO:0034723)4.14661963
22DNA replication-dependent nucleosome assembly (GO:0006335)4.14661963
23mitotic nuclear envelope disassembly (GO:0007077)4.09290491
24nucleotide-excision repair, DNA gap filling (GO:0006297)4.04214224
25DNA replication-independent nucleosome assembly (GO:0006336)3.92973998
26DNA replication-independent nucleosome organization (GO:0034724)3.92973998
27telomere maintenance via telomere lengthening (GO:0010833)3.92324713
28DNA unwinding involved in DNA replication (GO:0006268)3.90794452
29maturation of 5.8S rRNA (GO:0000460)3.89264838
30mitotic recombination (GO:0006312)3.89086686
31ribosomal small subunit biogenesis (GO:0042274)3.86362968
32membrane disassembly (GO:0030397)3.77889945
33nuclear envelope disassembly (GO:0051081)3.77889945
34regulation of sister chromatid cohesion (GO:0007063)3.76824747
35histone H2A monoubiquitination (GO:0035518)3.74067445
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71544384
37sister chromatid segregation (GO:0000819)3.69568864
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.63064997
39DNA topological change (GO:0006265)3.59853697
40histone exchange (GO:0043486)3.59534809
41negative regulation of meiosis (GO:0045835)3.52657670
42base-excision repair, AP site formation (GO:0006285)3.52436132
43transcription-coupled nucleotide-excision repair (GO:0006283)3.47468093
44regulation of spindle organization (GO:0090224)3.47150673
45protein localization to chromosome (GO:0034502)3.46851228
46V(D)J recombination (GO:0033151)3.45188535
47chromosome segregation (GO:0007059)3.44000793
48negative regulation of chromosome segregation (GO:0051985)3.40334554
49spindle checkpoint (GO:0031577)3.39541588
50regulation of chromosome segregation (GO:0051983)3.38535212
51meiotic chromosome segregation (GO:0045132)3.36966785
52mismatch repair (GO:0006298)3.36021068
53nucleobase biosynthetic process (GO:0046112)3.35540327
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35189775
55nuclear pore organization (GO:0006999)3.35178531
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34788804
57negative regulation of mitotic sister chromatid separation (GO:2000816)3.34620948
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34620948
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34620948
60negative regulation of sister chromatid segregation (GO:0033046)3.34620948
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.34199335
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.34082193
63kinetochore organization (GO:0051383)3.33036373
64chromatin assembly or disassembly (GO:0006333)3.32905919
65positive regulation of chromosome segregation (GO:0051984)3.32761398
66formation of translation preinitiation complex (GO:0001731)3.32127642
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31933731
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28776123
69proteasome assembly (GO:0043248)3.28440059
70regulation of histone H3-K27 methylation (GO:0061085)3.28251799
71kinetochore assembly (GO:0051382)3.26446594
72negative regulation of gene silencing (GO:0060969)3.25349683
73base-excision repair (GO:0006284)3.24450225
74viral mRNA export from host cell nucleus (GO:0046784)3.24365162
75establishment of integrated proviral latency (GO:0075713)3.24135762
76regulation of mitotic spindle organization (GO:0060236)3.22172202
77ribosome assembly (GO:0042255)3.22061719
78nucleobase-containing small molecule interconversion (GO:0015949)3.21827060
79piRNA metabolic process (GO:0034587)3.21724821
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21314304
81mitotic spindle checkpoint (GO:0071174)3.20937528
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20182929
83mitotic spindle assembly checkpoint (GO:0007094)3.20129077
84regulation of DNA methylation (GO:0044030)3.20100484
85establishment of viral latency (GO:0019043)3.19405304
86spindle assembly checkpoint (GO:0071173)3.18870391
87histone H2A ubiquitination (GO:0033522)3.18683742
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16953641
89isotype switching (GO:0045190)3.16953641
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16953641
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12586718
92nuclear pore complex assembly (GO:0051292)3.11969199
93regulation of posttranscriptional gene silencing (GO:0060147)3.11730358
94regulation of gene silencing by miRNA (GO:0060964)3.11730358
95regulation of gene silencing by RNA (GO:0060966)3.11730358
96regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11698886
97spliceosomal tri-snRNP complex assembly (GO:0000244)3.09642222
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08255432
99negative regulation of ligase activity (GO:0051352)3.08255432
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07599398
101mitochondrial fusion (GO:0008053)3.07379562
102Golgi transport vesicle coating (GO:0048200)3.07342611
103COPI coating of Golgi vesicle (GO:0048205)3.07342611
104regulation of mitotic sister chromatid separation (GO:0010965)3.07288222
105regulation of mitotic sister chromatid segregation (GO:0033047)3.07288222
106regulation of sister chromatid segregation (GO:0033045)3.07288222
107regulation of nuclear cell cycle DNA replication (GO:0033262)3.06719615
108regulation of telomere maintenance via telomerase (GO:0032210)3.06616036
109proline biosynthetic process (GO:0006561)3.06570346
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05376723
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05376723
112signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05374612
113signal transduction involved in DNA damage checkpoint (GO:0072422)3.05374612
114purine nucleobase biosynthetic process (GO:0009113)3.05137923
115regulation of centrosome cycle (GO:0046605)3.03654603
116DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03340717
117negative regulation of histone methylation (GO:0031061)3.02310389
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01917049
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01917049
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01917049
121telomere organization (GO:0032200)3.01349289
122telomere maintenance (GO:0000723)3.01209062
123meiotic cell cycle (GO:0051321)2.99292059
124protein deneddylation (GO:0000338)2.98881273
125maturation of SSU-rRNA (GO:0030490)2.98444365
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.98302640
127negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95990262
128negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.95990262
129hepatocyte apoptotic process (GO:0097284)2.91374331
130B cell receptor signaling pathway (GO:0050853)2.85384863
131ribonucleoprotein complex biogenesis (GO:0022613)2.85019745
132deoxyribonucleotide biosynthetic process (GO:0009263)2.84960405
133NADH metabolic process (GO:0006734)2.83360766
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81130299
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79085056
136regulation of cellular amino acid metabolic process (GO:0006521)2.78124231
137somatic diversification of immune receptors (GO:0002200)2.77407707
138protein maturation by protein folding (GO:0022417)2.74061665
139viral transcription (GO:0019083)2.73520670
140ribosome biogenesis (GO:0042254)2.72490691
141G1/S transition of mitotic cell cycle (GO:0000082)2.71822327
142cell cycle G1/S phase transition (GO:0044843)2.71822327
143mitotic sister chromatid cohesion (GO:0007064)2.71514875
144ribosomal small subunit assembly (GO:0000028)2.70149821
145regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.69934808
146positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.69934808
147regulation of translational fidelity (GO:0006450)2.69809945
148somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.68931558
149somatic cell DNA recombination (GO:0016444)2.68931558
150positive regulation of RNA splicing (GO:0033120)2.65677940
151positive regulation of ligase activity (GO:0051351)2.65147405
152chromosome condensation (GO:0030261)2.64732891
153spliceosomal snRNP assembly (GO:0000387)2.64529538
154positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63994780
155translational elongation (GO:0006414)2.62423951
156pentose-phosphate shunt (GO:0006098)2.61444184
157regulation of ubiquitin-protein transferase activity (GO:0051438)2.60892395
158nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59255331
159translational termination (GO:0006415)2.57591863
160B cell proliferation (GO:0042100)2.57114607
161tricarboxylic acid cycle (GO:0006099)2.56956047
162DNA synthesis involved in DNA repair (GO:0000731)2.56349233
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56269279
164folic acid metabolic process (GO:0046655)2.55939335
165translational initiation (GO:0006413)2.55779111
166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.54536447
167cellular protein complex localization (GO:0034629)2.54436435
168regulation of mitochondrial translation (GO:0070129)2.54319356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99011871
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75140342
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.97008129
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.72555180
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71707330
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02251826
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85514480
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85442209
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.70235452
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69118860
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.64019583
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61446125
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60680784
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.46308801
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35771932
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.29153381
17AR_21909140_ChIP-Seq_LNCAP_Human2.26739327
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24064961
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23990435
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20339075
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16505168
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13544488
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13514568
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12492584
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06653746
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.04308041
27XRN2_22483619_ChIP-Seq_HELA_Human2.03020678
28VDR_23849224_ChIP-Seq_CD4+_Human1.97711527
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93106758
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92801526
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89590281
32DCP1A_22483619_ChIP-Seq_HELA_Human1.87039482
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85563826
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83895673
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83360160
36FOXP3_21729870_ChIP-Seq_TREG_Human1.82586382
37GABP_19822575_ChIP-Seq_HepG2_Human1.80561045
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77197996
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74434010
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74434010
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74434010
42MYC_22102868_ChIP-Seq_BL_Human1.72488781
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70781225
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66040601
45TTF2_22483619_ChIP-Seq_HELA_Human1.63644558
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62631547
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61241353
48VDR_21846776_ChIP-Seq_THP-1_Human1.60777632
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60294800
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58170878
51CIITA_25753668_ChIP-Seq_RAJI_Human1.53309849
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46990583
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45996892
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45755607
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44959759
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.44480016
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44103955
58KDM5A_27292631_Chip-Seq_BREAST_Human1.43538755
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42890802
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41727029
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.40795539
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39637555
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36707502
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.35136683
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.29702417
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29690553
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27220845
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.27064300
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26612002
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26386193
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26107398
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26018383
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24455456
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23075623
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22814265
76RACK7_27058665_Chip-Seq_MCF-7_Human1.22009097
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18500618
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18174463
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.18064147
80MYC_18940864_ChIP-ChIP_HL60_Human1.18005279
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17966826
82ELK1_19687146_ChIP-ChIP_HELA_Human1.16506700
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.15070785
84TFEB_21752829_ChIP-Seq_HELA_Human1.14442030
85ZNF263_19887448_ChIP-Seq_K562_Human1.14286960
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13308292
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11308911
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10493192
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09846902
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09210567
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09051209
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08615125
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08315828
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08088981
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.07176722
96MAF_26560356_Chip-Seq_TH1_Human1.05934741
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05585468
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.03107188
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02994662
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01839037
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01216856
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00873069
103MAF_26560356_Chip-Seq_TH2_Human1.00058642
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99476702
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99003702
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98890356
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98799604
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98349760
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97727291
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96586905
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96300902
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95829736
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94888161
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94730496
115LXR_22292898_ChIP-Seq_THP-1_Human0.94705929
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94685553
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94680817
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93479045
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93275986
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92823985
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92426288
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91701272
123ATF3_27146783_Chip-Seq_COLON_Human0.91655486
124TCF7_22412390_ChIP-Seq_EML_Mouse0.90881595
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90682308
126KAP1_27257070_Chip-Seq_ESCs_Mouse0.87536973
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87331814
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85642034
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85384852
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85379892
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85320008
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82250454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.70321138
2MP0010094_abnormal_chromosome_stability5.32767519
3MP0004957_abnormal_blastocyst_morpholog4.73720076
4MP0003111_abnormal_nucleus_morphology4.65183676
5MP0003077_abnormal_cell_cycle4.31939876
6MP0008057_abnormal_DNA_replication3.49907089
7MP0003718_maternal_effect3.49371529
8MP0008058_abnormal_DNA_repair3.43219554
9MP0002653_abnormal_ependyma_morphology2.96626311
10MP0008932_abnormal_embryonic_tissue2.71595704
11MP0008877_abnormal_DNA_methylation2.69179037
12MP0008007_abnormal_cellular_replicative2.56161399
13MP0003123_paternal_imprinting2.51481571
14MP0006292_abnormal_olfactory_placode2.31776293
15MP0000350_abnormal_cell_proliferation2.29042466
16MP0001730_embryonic_growth_arrest2.28106956
17MP0000685_abnormal_immune_system1.96222704
18MP0003786_premature_aging1.95529293
19MP0003806_abnormal_nucleotide_metabolis1.91923090
20MP0010307_abnormal_tumor_latency1.86168165
21MP0005501_abnormal_skin_physiology1.85522555
22MP0010352_gastrointestinal_tract_polyps1.79975366
23MP0001697_abnormal_embryo_size1.79544623
24MP0002085_abnormal_embryonic_tissue1.77930780
25MP0003121_genomic_imprinting1.76479540
26MP0002019_abnormal_tumor_incidence1.73322919
27MP0008260_abnormal_autophagy1.72472584
28MP0002210_abnormal_sex_determination1.72080489
29MP0005387_immune_system_phenotype1.71970560
30MP0001790_abnormal_immune_system1.71970560
31MP0009278_abnormal_bone_marrow1.71057609
32MP0002132_abnormal_respiratory_system1.70606033
33MP0002796_impaired_skin_barrier1.70602774
34MP0001119_abnormal_female_reproductive1.65704043
35MP0005380_embryogenesis_phenotype1.65601887
36MP0001672_abnormal_embryogenesis/_devel1.65601887
37MP0005451_abnormal_body_composition1.65055846
38MP0004185_abnormal_adipocyte_glucose1.64638215
39MP0001929_abnormal_gametogenesis1.58624643
40MP0000490_abnormal_crypts_of1.57894460
41MP0004133_heterotaxia1.57108736
42MP0000653_abnormal_sex_gland1.55853725
43MP0002084_abnormal_developmental_patter1.52303496
44MP0002080_prenatal_lethality1.49288759
45MP0001727_abnormal_embryo_implantation1.48651907
46MP0002102_abnormal_ear_morphology1.46505802
47MP0003699_abnormal_female_reproductive1.43149821
48MP0001145_abnormal_male_reproductive1.42912762
49MP0003646_muscle_fatigue1.41465982
50MP0003890_abnormal_embryonic-extraembry1.38209459
51MP0005084_abnormal_gallbladder_morpholo1.36363844
52MP0005395_other_phenotype1.36353991
53MP0001853_heart_inflammation1.35709028
54MP0003984_embryonic_growth_retardation1.34987479
55MP0005423_abnormal_somatic_nervous1.34524659
56MP0006035_abnormal_mitochondrial_morpho1.34253425
57MP0008961_abnormal_basal_metabolism1.30976156
58MP0002088_abnormal_embryonic_growth/wei1.30448356
59MP0000313_abnormal_cell_death1.29001287
60MP0004947_skin_inflammation1.27310665
61MP0002086_abnormal_extraembryonic_tissu1.26016724
62MP0001835_abnormal_antigen_presentation1.26001968
63MP0005000_abnormal_immune_tolerance1.25274757
64MP0002877_abnormal_melanocyte_morpholog1.24276369
65MP0004381_abnormal_hair_follicle1.22445006
66MP0003763_abnormal_thymus_physiology1.21172461
67MP0003453_abnormal_keratinocyte_physiol1.20931886
68MP0002452_abnormal_antigen_presenting1.19103480
69MP0004264_abnormal_extraembryonic_tissu1.15377930
70MP0004233_abnormal_muscle_weight1.15341155
71MP0002098_abnormal_vibrissa_morphology1.13246085
72MP0003315_abnormal_perineum_morphology1.09191859
73MP0010030_abnormal_orbit_morphology1.08342136
74MP0002396_abnormal_hematopoietic_system1.07144766
75MP0001216_abnormal_epidermal_layer1.04888995
76MP0002420_abnormal_adaptive_immunity1.04560696
77MP0003119_abnormal_digestive_system1.04125462
78MP0003787_abnormal_imprinting1.02017388
79MP0002723_abnormal_immune_serum0.98805569
80MP0003436_decreased_susceptibility_to0.97401651
81MP0001819_abnormal_immune_cell0.97242594
82MP0003221_abnormal_cardiomyocyte_apopto0.96772913
83MP0009672_abnormal_birth_weight0.94766452
84MP0001873_stomach_inflammation0.94005783
85MP0002161_abnormal_fertility/fecundity0.92396532
86MP0003283_abnormal_digestive_organ0.92111764
87MP0001915_intracranial_hemorrhage0.91551432
88MP0005666_abnormal_adipose_tissue0.91507876
89MP0006072_abnormal_retinal_apoptosis0.91385496
90MP0010234_abnormal_vibrissa_follicle0.90682042
91MP0002822_catalepsy0.90625750
92MP0002398_abnormal_bone_marrow0.90562624
93MP0000689_abnormal_spleen_morphology0.89747531
94MP0004197_abnormal_fetal_growth/weight/0.89500709
95MP0005389_reproductive_system_phenotype0.89377429
96MP0005075_abnormal_melanosome_morpholog0.88820614
97MP0001849_ear_inflammation0.88525697
98MP0002160_abnormal_reproductive_system0.87986194
99MP0005621_abnormal_cell_physiology0.86103476
100MP0000703_abnormal_thymus_morphology0.84974185
101MP0003937_abnormal_limbs/digits/tail_de0.84383661
102MP0005384_cellular_phenotype0.83877695
103MP0002163_abnormal_gland_morphology0.83040624
104MP0000609_abnormal_liver_physiology0.82936970
105MP0000750_abnormal_muscle_regeneration0.81894106
106MP0005266_abnormal_metabolism0.80955083
107MP0000372_irregular_coat_pigmentation0.80676566
108MP0005330_cardiomyopathy0.79645103
109MP0002722_abnormal_immune_system0.79283413
110MP0002166_altered_tumor_susceptibility0.78274133
111MP0009931_abnormal_skin_appearance0.77560148
112MP0003136_yellow_coat_color0.74948841
113MP0001919_abnormal_reproductive_system0.74892071
114MP0002269_muscular_atrophy0.74694613
115MP0000377_abnormal_hair_follicle0.73707233
116MP0005379_endocrine/exocrine_gland_phen0.72600396
117MP0005023_abnormal_wound_healing0.72341390
118MP0002970_abnormal_white_adipose0.71744010
119MP0002249_abnormal_larynx_morphology0.71221715
120MP0003943_abnormal_hepatobiliary_system0.70707035
121MP0009333_abnormal_splenocyte_physiolog0.70452328
122MP0002405_respiratory_system_inflammati0.68993487
123MP0003941_abnormal_skin_development0.68077946
124MP0002429_abnormal_blood_cell0.67363493
125MP0001293_anophthalmia0.66879135
126MP0003186_abnormal_redox_activity0.66302237
127MP0001986_abnormal_taste_sensitivity0.66144310
128MP0005076_abnormal_cell_differentiation0.65619186
129MP0000358_abnormal_cell_content/0.64921310
130MP0003567_abnormal_fetal_cardiomyocyte0.63923020
131MP0002111_abnormal_tail_morphology0.63377177
132MP0003950_abnormal_plasma_membrane0.63359536
133MP0000477_abnormal_intestine_morphology0.62951490
134MP0000858_altered_metastatic_potential0.62570337
135MP0004808_abnormal_hematopoietic_stem0.62167322
136MP0001800_abnormal_humoral_immune0.61733759
137MP0006036_abnormal_mitochondrial_physio0.60461647
138MP0005257_abnormal_intraocular_pressure0.59914132
139MP0001529_abnormal_vocalization0.58373186
140MP0003698_abnormal_male_reproductive0.56733568
141MP0008789_abnormal_olfactory_epithelium0.55571232
142MP0005397_hematopoietic_system_phenotyp0.54832526
143MP0001545_abnormal_hematopoietic_system0.54832526
144MP0000716_abnormal_immune_system0.53868418
145MP0000678_abnormal_parathyroid_gland0.53324651
146MP0003861_abnormal_nervous_system0.52874803
147MP0002932_abnormal_joint_morphology0.50730802
148MP0005408_hypopigmentation0.50018826
149MP0001286_abnormal_eye_development0.49762412

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.19995680
2Breast hypoplasia (HP:0003187)5.20121282
3Agammaglobulinemia (HP:0004432)4.80019160
4Panhypogammaglobulinemia (HP:0003139)4.68769019
5Chromsome breakage (HP:0040012)4.62407367
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43875062
7Patellar aplasia (HP:0006443)4.04864328
8B lymphocytopenia (HP:0010976)4.02622531
9Hypoplasia of the thymus (HP:0000778)3.95543171
10Abnormality of the labia minora (HP:0012880)3.75893358
11Aplasia/Hypoplasia of the patella (HP:0006498)3.67336793
12Ependymoma (HP:0002888)3.65908046
13Medulloblastoma (HP:0002885)3.64766025
14Ragged-red muscle fibers (HP:0003200)3.61364986
15Absent radius (HP:0003974)3.49875889
16Supernumerary spleens (HP:0009799)3.48351057
17Rhabdomyosarcoma (HP:0002859)3.41441644
18Male infertility (HP:0003251)3.39811608
19Microvesicular hepatic steatosis (HP:0001414)3.39272962
20Abnormality of chromosome stability (HP:0003220)3.37695932
21Severe combined immunodeficiency (HP:0004430)3.33653903
22Oral leukoplakia (HP:0002745)3.32585875
23Meckel diverticulum (HP:0002245)3.29153870
24Aplasia involving forearm bones (HP:0009822)3.29003003
25Absent forearm bone (HP:0003953)3.29003003
26Gastrointestinal stroma tumor (HP:0100723)3.28447591
27Premature ovarian failure (HP:0008209)3.26281512
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.26071259
29Abnormality of the preputium (HP:0100587)3.22984940
30Abnormality of the ileum (HP:0001549)3.16195553
31Carpal bone hypoplasia (HP:0001498)3.09374959
32Duodenal stenosis (HP:0100867)3.06826687
33Small intestinal stenosis (HP:0012848)3.06826687
34Progressive muscle weakness (HP:0003323)3.03961334
35Abnormality of B cell number (HP:0010975)3.00842196
36Aplastic anemia (HP:0001915)2.97423313
37Abnormality of glycolysis (HP:0004366)2.92357565
38Colon cancer (HP:0003003)2.91670146
39Selective tooth agenesis (HP:0001592)2.82443984
40Absent thumb (HP:0009777)2.81137428
41Myelodysplasia (HP:0002863)2.79586131
42Recurrent viral infections (HP:0004429)2.78791162
43Verrucae (HP:0200043)2.77378111
44Papilloma (HP:0012740)2.77378111
45Agnosia (HP:0010524)2.74646655
46Cellulitis (HP:0100658)2.74240789
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72400317
48Abdominal situs inversus (HP:0003363)2.71589881
49Abnormality of abdominal situs (HP:0011620)2.71589881
50Neoplasm of striated muscle (HP:0009728)2.71111553
51Abnormality of DNA repair (HP:0003254)2.66787222
52Aplasia/Hypoplasia of the thymus (HP:0010515)2.66127704
53Reticulocytopenia (HP:0001896)2.65413188
54Breast aplasia (HP:0100783)2.62007489
55Lymphoma (HP:0002665)2.60530472
56Abnormality of the duodenum (HP:0002246)2.60156968
57Sloping forehead (HP:0000340)2.60053407
58Cholecystitis (HP:0001082)2.59217120
59Abnormal gallbladder physiology (HP:0012438)2.59217120
60Cerebral hypomyelination (HP:0006808)2.57767366
61Increased serum pyruvate (HP:0003542)2.55729789
62Neoplasm of the oral cavity (HP:0100649)2.54172386
63Basal cell carcinoma (HP:0002671)2.53221606
64Rough bone trabeculation (HP:0100670)2.52695835
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52559623
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52559623
67Progressive external ophthalmoplegia (HP:0000590)2.52538474
68Nephroblastoma (Wilms tumor) (HP:0002667)2.51903373
69Degeneration of anterior horn cells (HP:0002398)2.51587515
70Abnormality of the anterior horn cell (HP:0006802)2.51587515
71Adrenal hypoplasia (HP:0000835)2.51355703
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.51290943
73Aplasia/Hypoplasia of the breasts (HP:0010311)2.50603006
74Aplasia/Hypoplasia of the sternum (HP:0006714)2.50139358
75Shawl scrotum (HP:0000049)2.47406635
76Abnormal lung lobation (HP:0002101)2.45920181
77Duplicated collecting system (HP:0000081)2.45097401
78Secondary amenorrhea (HP:0000869)2.42999137
79Bone marrow hypocellularity (HP:0005528)2.42593455
80Cutaneous melanoma (HP:0012056)2.41652416
81Testicular atrophy (HP:0000029)2.36273718
82Colitis (HP:0002583)2.35590825
83Cafe-au-lait spot (HP:0000957)2.31636974
84Meningitis (HP:0001287)2.31259289
85Deep palmar crease (HP:0006191)2.30982515
86Astrocytoma (HP:0009592)2.29847166
87Abnormality of the astrocytes (HP:0100707)2.29847166
88Rib fusion (HP:0000902)2.28862357
89Recurrent bronchitis (HP:0002837)2.28734296
90Poikiloderma (HP:0001029)2.28041576
91Embryonal renal neoplasm (HP:0011794)2.27515220
92Impulsivity (HP:0100710)2.26523900
93IgM deficiency (HP:0002850)2.25040824
94Abnormal sex determination (HP:0012244)2.24158807
95Sex reversal (HP:0012245)2.24158807
96Abnormality of the renal collecting system (HP:0004742)2.21064973
97Microretrognathia (HP:0000308)2.18942983
98Trismus (HP:0000211)2.17084910
99Clubbing of toes (HP:0100760)2.14646750
100Horseshoe kidney (HP:0000085)2.12433640
101Neoplasm of the colon (HP:0100273)2.12255375
102Tracheoesophageal fistula (HP:0002575)2.10786388
103Seborrheic dermatitis (HP:0001051)2.10306373
104Abnormality of the carotid arteries (HP:0005344)2.09745214
105Squamous cell carcinoma (HP:0002860)2.09260993
106Myopathic facies (HP:0002058)2.08600789
107Pili torti (HP:0003777)2.07617143
108Premature graying of hair (HP:0002216)2.07119969
109Entropion (HP:0000621)2.06259657
110Atresia of the external auditory canal (HP:0000413)2.06016279
111Neoplasm of the pancreas (HP:0002894)2.04809023
112IgG deficiency (HP:0004315)2.04050994
113Ovarian neoplasm (HP:0100615)2.02395492
114Abnormality of cells of the erythroid lineage (HP:0012130)2.01188518
115Triphalangeal thumb (HP:0001199)2.00060469
116Micronodular cirrhosis (HP:0001413)1.98258178
117Rhabdomyolysis (HP:0003201)1.97587347
118Short thumb (HP:0009778)1.97295067
119Hyperacusis (HP:0010780)1.96541348
120Facial hemangioma (HP:0000329)1.96234447
121Multiple enchondromatosis (HP:0005701)1.94180533
122Pulmonary fibrosis (HP:0002206)1.93373204
123Dysphonia (HP:0001618)1.93221082
124Increased nuchal translucency (HP:0010880)1.92542521
125Slender long bone (HP:0003100)1.92411569
126Glioma (HP:0009733)1.90106173
127Aplasia/hypoplasia of the humerus (HP:0006507)1.89145285
128Proximal placement of thumb (HP:0009623)1.88004814
129Villous atrophy (HP:0011473)1.87230862
130Abnormality of small intestinal villus morphology (HP:0011472)1.87230862
131Sepsis (HP:0100806)1.86508492
132Hypokinesia (HP:0002375)1.86433307
133Biliary tract neoplasm (HP:0100574)1.86272237
134Ectopic kidney (HP:0000086)1.86154781
135IgA deficiency (HP:0002720)1.85997706
136Sparse eyelashes (HP:0000653)1.85353353
137Gastrointestinal inflammation (HP:0004386)1.84583023
138Pancytopenia (HP:0001876)1.83223629
139Abnormal number of erythroid precursors (HP:0012131)1.81628984
140Distal lower limb muscle weakness (HP:0009053)1.81473997
141Delayed puberty (HP:0000823)1.81269753
142Cellular immunodeficiency (HP:0005374)1.80988756
143Viral hepatitis (HP:0006562)1.80211301
144Cortical dysplasia (HP:0002539)1.79687148
145Cleft eyelid (HP:0000625)1.79583826
146Recurrent otitis media (HP:0000403)1.79286018
147Abnormal number of incisors (HP:0011064)1.79015083
148Abnormal mitochondria in muscle tissue (HP:0008316)1.78919383
149Asplenia (HP:0001746)1.78233872
150Abnormality of the thymus (HP:0000777)1.77704014
151Exercise intolerance (HP:0003546)1.77073132
152Osteomyelitis (HP:0002754)1.76055738
153Overlapping toe (HP:0001845)1.74871235
154Combined immunodeficiency (HP:0005387)1.74850627
155Granulocytopenia (HP:0001913)1.74786776
156Intestinal polyp (HP:0005266)1.74652063
157Abnormality of pyrimidine metabolism (HP:0004353)1.74384217
158Lymphopenia (HP:0001888)1.73604971
159Abnormal trabecular bone morphology (HP:0100671)1.72852724
160Macrocytic anemia (HP:0001972)1.72180465
161Septate vagina (HP:0001153)1.70643259
162Microglossia (HP:0000171)1.66953717
163Personality changes (HP:0000751)1.66411875
164Hypoparathyroidism (HP:0000829)1.65899811
165Deviation of the thumb (HP:0009603)1.65217352
166Long palpebral fissure (HP:0000637)1.64777570
167Gout (HP:0001997)1.64519110
168Amniotic constriction ring (HP:0009775)1.64085112
169Abnormality of placental membranes (HP:0011409)1.64085112
170Hepatic necrosis (HP:0002605)1.63749577
171Increased muscle lipid content (HP:0009058)1.63686122
172Increased intramyocellular lipid droplets (HP:0012240)1.63195137
173Abnormality of T cells (HP:0002843)1.63163410
174Insomnia (HP:0100785)1.63034859
175Overriding aorta (HP:0002623)1.61585434
176Muscle stiffness (HP:0003552)1.59763371
177Progressive hearing impairment (HP:0001730)1.59702678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.79334019
2CDC74.20897295
3ERN13.59835204
4TTK3.59076024
5MAP3K103.40000697
6SMG13.27357247
7WEE13.02560019
8NEK12.83941787
9NEK22.72138592
10VRK22.64256553
11PLK42.53663672
12MOS2.47378096
13PRPF4B2.28629687
14MST42.28173307
15ACVR1B2.25544911
16SIK32.22535683
17MAP3K62.21533335
18PLK12.20454165
19BRAF2.20310479
20BMPR22.03194033
21EIF2AK12.01903003
22TESK11.97287996
23STK38L1.91940928
24TRIB31.89471496
25MAPKAPK31.85971879
26RPS6KB21.84425657
27EEF2K1.80248751
28STK101.78507363
29CHEK21.75118198
30SRPK11.72427289
31IRAK31.67875138
32PBK1.65686957
33MAP3K81.65502147
34CDK71.62452963
35PASK1.58762584
36AURKB1.58615366
37CDK81.57123046
38SIK11.55074759
39BRSK21.54312756
40LATS21.54026501
41VRK11.51622517
42TESK21.48499104
43ATR1.46491854
44EIF2AK31.45202371
45MELK1.40353864
46AURKA1.40117077
47LATS11.36904160
48TAOK31.35727478
49ERBB41.34146331
50TAOK21.29691095
51EPHA21.29203247
52KSR21.22525853
53BRSK11.19436815
54PLK31.18923592
55CDK121.18718155
56ARAF1.11370575
57CHEK11.10475534
58MAP3K91.09871506
59TSSK61.08899049
60DYRK21.07106594
61PRKCI1.06161937
62RAF11.05388132
63TAOK11.04605139
64IRAK41.02588036
65MAP3K31.01797617
66CDK41.00787408
67TRIM280.97712944
68DYRK30.97526387
69MAP4K10.97279921
70RPS6KA40.95883380
71MKNK20.93999513
72MST1R0.93069817
73DAPK10.92693758
74NME20.91063483
75NME10.87125627
76ATM0.86454128
77TGFBR10.85565626
78PAK40.84314431
79ICK0.83938710
80PDK20.82967963
81FLT30.82197366
82CDK90.81347914
83MKNK10.78645507
84TAF10.74956316
85TLK10.73430903
86CCNB10.73285649
87CDK20.72969798
88MAP3K130.72945506
89CSNK1G30.72211124
90MAP2K30.72053114
91CSNK1G10.70430482
92STK160.66010123
93PIM10.65400216
94BRD40.59259072
95STK40.57389593
96NEK60.56814724
97MAP3K140.55813060
98CDK10.54818360
99EIF2AK20.54571214
100LMTK20.54159645
101BLK0.53071966
102LIMK10.52875998
103HIPK20.52704736
104PIM20.52113492
105RIPK10.50069982
106PKN20.49382694
107PAK10.48810518
108STK30.48384441
109CSNK1A1L0.47367650
110NTRK20.47173371
111CSNK2A10.46689019
112SCYL20.46332034
113RIPK40.45188347
114CSNK2A20.40891171
115MAP3K110.39642609
116RPS6KB10.39497871
117MET0.39351407
118FGFR40.38755170
119JAK30.36815329
120NLK0.36737881
121KSR10.35943689
122BCKDK0.33384871
123CSNK1G20.32989798
124MAP3K120.32723460
125MAP2K20.30553635
126MAPKAPK20.30372189
127MUSK0.28887899
128LRRK20.27967683
129CSNK1D0.27572751
130CLK10.25051800
131MAP3K50.24004961
132CDK60.23366817
133MAPK110.22891903
134ALK0.19508069
135CSNK1E0.19261889
136GRK60.18867250
137PRKDC0.17367794
138AKT20.17220050
139ABL20.15819310
140AKT10.15677919
141BTK0.15456768

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.45548704
2Mismatch repair_Homo sapiens_hsa034305.07223768
3Base excision repair_Homo sapiens_hsa034103.82830071
4Homologous recombination_Homo sapiens_hsa034403.42076086
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38246194
6Nucleotide excision repair_Homo sapiens_hsa034203.37935395
7Cell cycle_Homo sapiens_hsa041103.27905021
8RNA polymerase_Homo sapiens_hsa030203.14713885
9RNA transport_Homo sapiens_hsa030132.98795643
10Spliceosome_Homo sapiens_hsa030402.82425015
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.80020189
12Fanconi anemia pathway_Homo sapiens_hsa034602.71730503
13Basal transcription factors_Homo sapiens_hsa030222.65870008
14RNA degradation_Homo sapiens_hsa030182.61993759
15One carbon pool by folate_Homo sapiens_hsa006702.50819346
16Proteasome_Homo sapiens_hsa030502.34194862
17Pyrimidine metabolism_Homo sapiens_hsa002402.33417485
18Non-homologous end-joining_Homo sapiens_hsa034502.25473361
19Ribosome_Homo sapiens_hsa030102.24173962
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11749119
21mRNA surveillance pathway_Homo sapiens_hsa030151.82295724
22p53 signaling pathway_Homo sapiens_hsa041151.75050583
23Oocyte meiosis_Homo sapiens_hsa041141.49460508
24Purine metabolism_Homo sapiens_hsa002301.26938820
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22121283
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18144214
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17319955
28Pyruvate metabolism_Homo sapiens_hsa006201.10812023
29Vibrio cholerae infection_Homo sapiens_hsa051101.10009330
30Fatty acid elongation_Homo sapiens_hsa000621.03013601
31Epstein-Barr virus infection_Homo sapiens_hsa051691.02581208
32Parkinsons disease_Homo sapiens_hsa050120.97165772
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95017324
34Folate biosynthesis_Homo sapiens_hsa007900.93485687
35Primary immunodeficiency_Homo sapiens_hsa053400.89271597
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.86434845
37Oxidative phosphorylation_Homo sapiens_hsa001900.84480263
38TGF-beta signaling pathway_Homo sapiens_hsa043500.79638142
39Acute myeloid leukemia_Homo sapiens_hsa052210.79502017
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77180792
41HTLV-I infection_Homo sapiens_hsa051660.76664863
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.76451346
43Herpes simplex infection_Homo sapiens_hsa051680.74869624
44Biosynthesis of amino acids_Homo sapiens_hsa012300.74088326
45Viral carcinogenesis_Homo sapiens_hsa052030.73358408
46MicroRNAs in cancer_Homo sapiens_hsa052060.68713950
47Colorectal cancer_Homo sapiens_hsa052100.66852923
48Thyroid cancer_Homo sapiens_hsa052160.66384954
49Protein export_Homo sapiens_hsa030600.66092259
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.64809970
51Antigen processing and presentation_Homo sapiens_hsa046120.61300460
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59981170
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59907744
54Galactose metabolism_Homo sapiens_hsa000520.59416280
55Linoleic acid metabolism_Homo sapiens_hsa005910.58147718
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57514832
57Sulfur metabolism_Homo sapiens_hsa009200.56980626
58Vitamin B6 metabolism_Homo sapiens_hsa007500.50499653
59Hippo signaling pathway_Homo sapiens_hsa043900.49956835
60Systemic lupus erythematosus_Homo sapiens_hsa053220.49701071
61Circadian rhythm_Homo sapiens_hsa047100.48725963
62Selenocompound metabolism_Homo sapiens_hsa004500.47855932
63Bladder cancer_Homo sapiens_hsa052190.47666262
64Measles_Homo sapiens_hsa051620.45370034
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44634548
66Insulin signaling pathway_Homo sapiens_hsa049100.44459019
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44410846
68Small cell lung cancer_Homo sapiens_hsa052220.44348787
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44158723
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43778910
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42663446
72Pancreatic cancer_Homo sapiens_hsa052120.42320942
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.42312441
74Notch signaling pathway_Homo sapiens_hsa043300.41160978
75Hepatitis C_Homo sapiens_hsa051600.40248652
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38848372
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38559671
78Ovarian steroidogenesis_Homo sapiens_hsa049130.36748956
79Alzheimers disease_Homo sapiens_hsa050100.36266725
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35711454
81Phenylalanine metabolism_Homo sapiens_hsa003600.35539388
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34769765
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34399936
84Apoptosis_Homo sapiens_hsa042100.34075340
85Pentose phosphate pathway_Homo sapiens_hsa000300.31858900
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31614193
87Hepatitis B_Homo sapiens_hsa051610.31459446
88Influenza A_Homo sapiens_hsa051640.30343644
89mTOR signaling pathway_Homo sapiens_hsa041500.29806265
90Huntingtons disease_Homo sapiens_hsa050160.29278439
91Renal cell carcinoma_Homo sapiens_hsa052110.29066595
92Glutathione metabolism_Homo sapiens_hsa004800.28559280
93Shigellosis_Homo sapiens_hsa051310.28523690
94Sulfur relay system_Homo sapiens_hsa041220.28017690
95Endometrial cancer_Homo sapiens_hsa052130.27088272
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26726485
97Fructose and mannose metabolism_Homo sapiens_hsa000510.26291042
98Prion diseases_Homo sapiens_hsa050200.25266519
99T cell receptor signaling pathway_Homo sapiens_hsa046600.24398432
100Adherens junction_Homo sapiens_hsa045200.21600687
101Pathways in cancer_Homo sapiens_hsa052000.19900414
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.18374360
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17960471
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17651734
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17577859
106Other glycan degradation_Homo sapiens_hsa005110.17551262
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.17532654
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17459981
109Basal cell carcinoma_Homo sapiens_hsa052170.17148938
110Legionellosis_Homo sapiens_hsa051340.15451503
111N-Glycan biosynthesis_Homo sapiens_hsa005100.15295073
112VEGF signaling pathway_Homo sapiens_hsa043700.13895749
113Arginine and proline metabolism_Homo sapiens_hsa003300.13779033
114Chronic myeloid leukemia_Homo sapiens_hsa052200.13540689
115B cell receptor signaling pathway_Homo sapiens_hsa046620.13385846
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13105415
117Arachidonic acid metabolism_Homo sapiens_hsa005900.12698222
118Prostate cancer_Homo sapiens_hsa052150.12696470
119Alcoholism_Homo sapiens_hsa050340.12635891
120Non-small cell lung cancer_Homo sapiens_hsa052230.12165769
121Hedgehog signaling pathway_Homo sapiens_hsa043400.12098991
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11396137
123Ether lipid metabolism_Homo sapiens_hsa005650.10928217
124HIF-1 signaling pathway_Homo sapiens_hsa040660.09901564
125Wnt signaling pathway_Homo sapiens_hsa043100.09678001
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09173201
127FoxO signaling pathway_Homo sapiens_hsa040680.08908762
128Metabolic pathways_Homo sapiens_hsa011000.08715651
129Carbon metabolism_Homo sapiens_hsa012000.07660786
130Melanoma_Homo sapiens_hsa052180.07582152
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.07478302

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