HMCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peripheral nervous system axon ensheathment (GO:0032292)5.08627526
2myelination in peripheral nervous system (GO:0022011)5.08627526
3extracellular matrix assembly (GO:0085029)5.00841842
4response to inactivity (GO:0014854)4.97281741
5extracellular fibril organization (GO:0043206)4.84254049
6lung epithelium development (GO:0060428)4.84117699
7protein heterotrimerization (GO:0070208)4.78639588
8collagen fibril organization (GO:0030199)4.66843274
9negative regulation of cytosolic calcium ion concentration (GO:0051481)4.65771453
10regulation of skeletal muscle contraction (GO:0014819)4.63798990
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.62105178
12actin-myosin filament sliding (GO:0033275)4.61610529
13muscle filament sliding (GO:0030049)4.61610529
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.58650595
15skeletal muscle adaptation (GO:0043501)4.57820658
16plasma membrane repair (GO:0001778)4.48742003
17relaxation of smooth muscle (GO:0044557)4.40137536
18response to muscle activity (GO:0014850)4.26281598
19fibril organization (GO:0097435)4.23721934
20actin-mediated cell contraction (GO:0070252)4.13939219
21cardiac myofibril assembly (GO:0055003)4.11383864
22regulation of bile acid biosynthetic process (GO:0070857)4.10211953
23skin morphogenesis (GO:0043589)4.10166257
24myotube cell development (GO:0014904)4.07891398
25muscle system process (GO:0003012)4.01093724
26regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.98456598
27regulation of extracellular matrix disassembly (GO:0010715)3.89757927
28myofibril assembly (GO:0030239)3.82336540
29regulation of p38MAPK cascade (GO:1900744)3.79562410
30sarcomere organization (GO:0045214)3.78649153
31cGMP-mediated signaling (GO:0019934)3.78393843
32keratan sulfate catabolic process (GO:0042340)3.77970777
33collagen metabolic process (GO:0032963)3.77232973
34regulation of cGMP biosynthetic process (GO:0030826)3.75354550
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.74085119
36sequestering of extracellular ligand from receptor (GO:0035581)3.73307675
37sodium ion export (GO:0071436)3.71728586
38cellular sodium ion homeostasis (GO:0006883)3.71234717
39cardiac muscle hypertrophy (GO:0003300)3.64889744
40multicellular organismal macromolecule metabolic process (GO:0044259)3.63498396
41regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.63303557
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56214371
43skeletal muscle tissue development (GO:0007519)3.51369400
44striated muscle atrophy (GO:0014891)3.51331909
45NADH metabolic process (GO:0006734)3.50000408
46striated muscle adaptation (GO:0014888)3.49876664
47positive regulation of cGMP biosynthetic process (GO:0030828)3.48115444
48regulation of cholesterol homeostasis (GO:2000188)3.47250183
49regulation of cell communication by electrical coupling (GO:0010649)3.46275937
50multicellular organismal metabolic process (GO:0044236)3.44620081
51retina vasculature morphogenesis in camera-type eye (GO:0061299)3.44209030
52cardiac muscle cell development (GO:0055013)3.41772708
53collagen catabolic process (GO:0030574)3.41593030
54positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41045503
55organ induction (GO:0001759)3.39641298
56carnitine shuttle (GO:0006853)3.39481257
57negative regulation of heart growth (GO:0061117)3.37403314
58negative regulation of cardiac muscle tissue growth (GO:0055022)3.37403314
59regulation of striated muscle contraction (GO:0006942)3.32027834
60actin filament-based movement (GO:0030048)3.31718092
61basement membrane organization (GO:0071711)3.29987385
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.29603210
63regulation of relaxation of muscle (GO:1901077)3.29313567
64negative regulation of potassium ion transmembrane transport (GO:1901380)3.28005654
65cardiac cell development (GO:0055006)3.27952333
66positive regulation of p38MAPK cascade (GO:1900745)3.27193134
67urinary tract smooth muscle contraction (GO:0014848)3.26965757
68negative regulation of Rho protein signal transduction (GO:0035024)3.24882177
69positive regulation of sodium ion transmembrane transport (GO:1902307)3.22611127
70multicellular organismal catabolic process (GO:0044243)3.20631895
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.20347660
72creatine metabolic process (GO:0006600)3.19270801
73regulation of guanylate cyclase activity (GO:0031282)3.18968966
74sarcoplasmic reticulum calcium ion transport (GO:0070296)3.18303338
75negative regulation of protein autophosphorylation (GO:0031953)3.17378556
76striated muscle cell development (GO:0055002)3.16820236
77negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15667573
78positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.15113907
79regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.15034052
80regulation of actin filament-based movement (GO:1903115)3.13948669
81cardiac muscle contraction (GO:0060048)3.13497241
82glomerular basement membrane development (GO:0032836)3.13188510
83embryonic retina morphogenesis in camera-type eye (GO:0060059)3.12678428
84motile cilium assembly (GO:0044458)3.12169707
85carnitine transmembrane transport (GO:1902603)3.11860795
86muscle cell cellular homeostasis (GO:0046716)3.10590252
87positive regulation of myotube differentiation (GO:0010831)3.08372020
88fatty acid transmembrane transport (GO:1902001)3.07316954
89carnitine transport (GO:0015879)3.06322779
90amino-acid betaine transport (GO:0015838)3.06322779
91regulation of cGMP metabolic process (GO:0030823)3.05841061
92cell communication by electrical coupling (GO:0010644)3.05142737
93striated muscle hypertrophy (GO:0014897)3.04821141
94muscle cell fate commitment (GO:0042693)3.00212470
95positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.99812817
96neuromuscular synaptic transmission (GO:0007274)2.96796927
97syncytium formation by plasma membrane fusion (GO:0000768)2.96688874
98membrane depolarization during action potential (GO:0086010)2.96576815
99striated muscle contraction (GO:0006941)2.95898794
100muscle atrophy (GO:0014889)2.94582273
101skeletal muscle contraction (GO:0003009)2.93935088
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.93652561
103epithelial cell-cell adhesion (GO:0090136)2.92548975
104response to caffeine (GO:0031000)2.92522196
105fibroblast migration (GO:0010761)2.91275743
106heart trabecula formation (GO:0060347)2.91081275
107negative regulation of stress fiber assembly (GO:0051497)2.87742673
108skeletal muscle fiber development (GO:0048741)2.87414123
109positive regulation of fatty acid oxidation (GO:0046321)2.87072590
110positive regulation of cGMP metabolic process (GO:0030825)2.86905789
111peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86531265
112muscle fiber development (GO:0048747)2.85675597
113bone trabecula formation (GO:0060346)2.85147961
114regulation of calcium ion transmembrane transporter activity (GO:1901019)2.84494849
115regulation of calcium ion transmembrane transport (GO:1903169)2.84494849
116glucan catabolic process (GO:0009251)2.84443488
117cardiac muscle cell proliferation (GO:0060038)2.82787415
118muscle cell development (GO:0055001)2.81692190
119cardiac muscle hypertrophy in response to stress (GO:0014898)2.81440821
120muscle hypertrophy in response to stress (GO:0003299)2.81440821
121cardiac muscle adaptation (GO:0014887)2.81440821
122adult heart development (GO:0007512)2.81261650
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80208555
124growth hormone secretion (GO:0030252)2.79941707
125trabecula formation (GO:0060343)2.79727337
126regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.79689608
127striated muscle tissue development (GO:0014706)2.79053042
128positive regulation of cation channel activity (GO:2001259)2.78643728
129growth hormone receptor signaling pathway (GO:0060396)2.78561852
130muscle organ development (GO:0007517)2.77123813
131muscle adaptation (GO:0043500)2.76394240
132positive regulation of respiratory burst (GO:0060267)2.75947055
133syncytium formation (GO:0006949)2.75457577
134glycogen catabolic process (GO:0005980)2.75011989
135extracellular matrix disassembly (GO:0022617)2.74842750
136calcium ion import (GO:0070509)2.74385227
137regulation of sarcomere organization (GO:0060297)2.74197142
138muscle structure development (GO:0061061)2.74190019
139regulation of muscle system process (GO:0090257)2.72392559
140skeletal muscle tissue regeneration (GO:0043403)2.72375180
141relaxation of muscle (GO:0090075)2.71708373
142regulation of muscle contraction (GO:0006937)2.70556538
143muscle hypertrophy (GO:0014896)2.70501543
144actomyosin structure organization (GO:0031032)2.70257483
145positive regulation of guanylate cyclase activity (GO:0031284)2.69269920
146fructose metabolic process (GO:0006000)2.69147956
147muscle tissue morphogenesis (GO:0060415)2.69056114
148muscle contraction (GO:0006936)2.67731588
149striated muscle cell proliferation (GO:0014855)2.67392184
150regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.66961311
151positive regulation of glycogen biosynthetic process (GO:0045725)2.66536146
152endodermal cell differentiation (GO:0035987)2.65767885
153lung vasculature development (GO:0060426)2.65687403
154regulation of skeletal muscle cell differentiation (GO:2001014)2.64768151
155actin filament depolymerization (GO:0030042)2.61899974
156cellular response to epinephrine stimulus (GO:0071872)2.61784495
157quaternary ammonium group transport (GO:0015697)2.60189464
158response to epinephrine (GO:0071871)2.57818361
159myoblast fusion (GO:0007520)2.57415052
160muscle tissue development (GO:0060537)2.57389428
161cellular polysaccharide catabolic process (GO:0044247)2.57141389
162glomerular filtration (GO:0003094)2.56768714
163positive regulation of ion transmembrane transporter activity (GO:0032414)2.55970871
164regulation of synapse maturation (GO:0090128)2.50323902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.53110435
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.31206902
3CLOCK_20551151_ChIP-Seq_293T_Human3.17008587
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.08132593
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93966581
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66090377
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59992282
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.46944705
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.40015307
10GBX2_23144817_ChIP-Seq_PC3_Human2.33110412
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.27253930
12VDR_22108803_ChIP-Seq_LS180_Human2.21103269
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04923027
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02840003
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00640677
16DROSHA_22980978_ChIP-Seq_HELA_Human1.97445303
17CJUN_26792858_Chip-Seq_BT549_Human1.96605551
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.95491391
19EZH2_22144423_ChIP-Seq_EOC_Human1.93360601
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92915939
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89076758
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88249594
23AR_21572438_ChIP-Seq_LNCaP_Human1.85282793
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.84414762
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.84414762
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76150369
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72232705
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71135208
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.70215990
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68918115
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63574389
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57918312
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57887079
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57887079
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56533520
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.56059130
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54344533
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52300991
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50830880
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.48960956
41CTCF_27219007_Chip-Seq_Bcells_Human1.48076294
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47971065
43IGF1R_20145208_ChIP-Seq_DFB_Human1.47949700
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46645875
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45539180
46ZNF263_19887448_ChIP-Seq_K562_Human1.44625736
47KDM2B_26808549_Chip-Seq_K562_Human1.44451744
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43930688
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39567982
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39106324
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38535237
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37553875
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.34533718
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30776054
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29673291
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28995833
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.28959426
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28540826
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.28494698
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.28342316
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.28000921
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27936618
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.27537439
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27224410
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26517992
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25595331
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24610629
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22771325
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22240801
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.20318004
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20315295
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20242505
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19775872
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19775872
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.19573556
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.19227666
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18802745
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18044875
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17915961
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17194731
81KDM2B_26808549_Chip-Seq_DND41_Human1.16565123
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16284293
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15725493
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14067683
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13890258
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13781967
87SMAD4_21799915_ChIP-Seq_A2780_Human1.13488958
88OCT4_20526341_ChIP-Seq_ESCs_Human1.13270674
89BCAT_22108803_ChIP-Seq_LS180_Human1.13097267
90RXR_22108803_ChIP-Seq_LS180_Human1.12537805
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11972400
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.10182895
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10106736
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09576258
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09566835
96BRD4_25478319_ChIP-Seq_HGPS_Human1.09094250
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07539806
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07155105
99TP53_16413492_ChIP-PET_HCT116_Human1.06396014
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05884161
101RACK7_27058665_Chip-Seq_MCF-7_Human1.05578917
102SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05319846
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05211483
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.05052344
105ER_23166858_ChIP-Seq_MCF-7_Human1.05014340
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.04211512
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03936023
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.03005967
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.02879866
110TCF4_23295773_ChIP-Seq_U87_Human1.02122044
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02013443
112LXR_22292898_ChIP-Seq_THP-1_Human1.01898611
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01565436
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.01454270
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01239921
116CBP_20019798_ChIP-Seq_JUKART_Human1.01239921
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01109277
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00585648
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.99493144
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.99348809
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99052365
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99052365
123EGR1_19032775_ChIP-ChIP_M12_Human0.98774000
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.98623762
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.98393659
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.97161345
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97042142
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96739135
129STAT3_23295773_ChIP-Seq_U87_Human0.96716114
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96569826
131ISL1_27105846_Chip-Seq_CPCs_Mouse0.95714056
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.95591988
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95546604
134AHR_22903824_ChIP-Seq_MCF-7_Human0.94692618
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.94635169
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93871262
137GATA1_22025678_ChIP-Seq_K562_Human0.93157428
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92521603
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91486275
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90472392
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90098244
142NANOG_20526341_ChIP-Seq_ESCs_Human0.89499429
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.89425537
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89101227
145AR_19668381_ChIP-Seq_PC3_Human0.88012599
146MYC_19829295_ChIP-Seq_ESCs_Human0.86742552
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86511899
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.85975105
149ERA_21632823_ChIP-Seq_H3396_Human0.85510213
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.84888777
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84454730
152FOXA2_19822575_ChIP-Seq_HepG2_Human0.84266613
153TBL1_22424771_ChIP-Seq_293T_Human0.83314097
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82963752
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82794440
156CDX2_22108803_ChIP-Seq_LS180_Human0.82693282
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82007799
158RUNX2_22187159_ChIP-Seq_PCA_Human0.81972003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.90751402
2MP0005275_abnormal_skin_tensile5.29727555
3MP0000751_myopathy5.08186031
4MP0005503_abnormal_tendon_morphology4.27922356
5MP0000750_abnormal_muscle_regeneration3.45921500
6MP0000749_muscle_degeneration3.34709859
7MP0002837_dystrophic_cardiac_calcinosis2.99030410
8MP0002108_abnormal_muscle_morphology2.88651109
9MP0004145_abnormal_muscle_electrophysio2.85478184
10MP0004084_abnormal_cardiac_muscle2.68203644
11MP0003705_abnormal_hypodermis_morpholog2.59173597
12MP0004036_abnormal_muscle_relaxation2.47729304
13MP0004233_abnormal_muscle_weight2.43070305
14MP0005257_abnormal_intraocular_pressure2.34356190
15MP0004087_abnormal_muscle_fiber2.33814583
16MP0000733_abnormal_muscle_development2.32487570
17MP0000747_muscle_weakness2.31196453
18MP0004272_abnormal_basement_membrane2.27156132
19MP0002106_abnormal_muscle_physiology2.26836066
20MP0000759_abnormal_skeletal_muscle2.16968419
21MP0005369_muscle_phenotype2.14576376
22MP0001958_emphysema2.09972165
23MP0003646_muscle_fatigue2.09098005
24MP0003950_abnormal_plasma_membrane1.97097421
25MP0005330_cardiomyopathy1.92536437
26MP0002166_altered_tumor_susceptibility1.88855993
27MP0003279_aneurysm1.85981093
28MP0002269_muscular_atrophy1.85330854
29MP0005623_abnormal_meninges_morphology1.84847089
30MP0002822_catalepsy1.83863898
31MP0004215_abnormal_myocardial_fiber1.83573717
32MP0002060_abnormal_skin_morphology1.81643182
33MP0008775_abnormal_heart_ventricle1.75013176
34MP0002006_tumorigenesis1.70201674
35MP0005360_urolithiasis1.68347180
36MP0005620_abnormal_muscle_contractility1.66576767
37MP0002254_reproductive_system_inflammat1.62654046
38MP0001664_abnormal_digestion1.62004293
39MP0003878_abnormal_ear_physiology1.58661161
40MP0005377_hearing/vestibular/ear_phenot1.58661161
41MP0004130_abnormal_muscle_cell1.53294600
42MP0003879_abnormal_hair_cell1.44837433
43MP0005167_abnormal_blood-brain_barrier1.43752628
44MP0003045_fibrosis1.39230436
45MP0002090_abnormal_vision1.37741473
46MP0005670_abnormal_white_adipose1.35804548
47MP0000230_abnormal_systemic_arterial1.35535248
48MP0010030_abnormal_orbit_morphology1.29700722
49MP0005508_abnormal_skeleton_morphology1.28138431
50MP0001501_abnormal_sleep_pattern1.27936432
51MP0002638_abnormal_pupillary_reflex1.26899963
52MP0002249_abnormal_larynx_morphology1.23341955
53MP0010630_abnormal_cardiac_muscle1.22082611
54MP0002972_abnormal_cardiac_muscle1.18870603
55MP0005409_darkened_coat_color1.17380674
56MP0004043_abnormal_pH_regulation1.16900192
57MP0000013_abnormal_adipose_tissue1.15328483
58MP0010368_abnormal_lymphatic_system1.14705220
59MP0005385_cardiovascular_system_phenoty1.14516153
60MP0001544_abnormal_cardiovascular_syste1.14516153
61MP0005666_abnormal_adipose_tissue1.14037129
62MP0001485_abnormal_pinna_reflex1.12948880
63MP0005375_adipose_tissue_phenotype1.11291847
64MP0004510_myositis1.10666181
65MP0002163_abnormal_gland_morphology1.09581473
66MP0002332_abnormal_exercise_endurance1.06872243
67MP0005451_abnormal_body_composition1.05893185
68MP0000003_abnormal_adipose_tissue1.05719064
69MP0005266_abnormal_metabolism1.05550619
70MP0005410_abnormal_fertilization1.03188904
71MP0001299_abnormal_eye_distance/1.01538952
72MP0002876_abnormal_thyroid_physiology1.00721991
73MP0002234_abnormal_pharynx_morphology0.99694388
74MP0003566_abnormal_cell_adhesion0.98812671
75MP0004147_increased_porphyrin_level0.97703641
76MP0000462_abnormal_digestive_system0.95397628
77MP0003183_abnormal_peptide_metabolism0.93424361
78MP0006138_congestive_heart_failure0.93412655
79MP0005595_abnormal_vascular_smooth0.93376555
80MP0003221_abnormal_cardiomyocyte_apopto0.93287879
81MP0004270_analgesia0.92676966
82MP0002877_abnormal_melanocyte_morpholog0.91965561
83MP0001756_abnormal_urination0.90774229
84MP0009780_abnormal_chondrocyte_physiolo0.90033995
85MP0003828_pulmonary_edema0.89388889
86MP0000767_abnormal_smooth_muscle0.89318558
87MP0000538_abnormal_urinary_bladder0.88837943
88MP0010352_gastrointestinal_tract_polyps0.87527738
89MP0002089_abnormal_postnatal_growth/wei0.87112572
90MP0000534_abnormal_ureter_morphology0.85942291
91MP0002971_abnormal_brown_adipose0.83442663
92MP0001984_abnormal_olfaction0.83201219
93MP0003137_abnormal_impulse_conducting0.82743883
94MP0001188_hyperpigmentation0.81857883
95MP0005332_abnormal_amino_acid0.81010637
96MP0005076_abnormal_cell_differentiation0.79570664
97MP0002933_joint_inflammation0.78528015
98MP0004185_abnormal_adipocyte_glucose0.76783387
99MP0004085_abnormal_heartbeat0.74707602
100MP0002078_abnormal_glucose_homeostasis0.72856785
101MP0006036_abnormal_mitochondrial_physio0.72448369
102MP0001502_abnormal_circadian_rhythm0.71489824
103MP0001243_abnormal_dermal_layer0.70616048
104MP0005165_increased_susceptibility_to0.70080397
105MP0002896_abnormal_bone_mineralization0.69517021
106MP0005085_abnormal_gallbladder_physiolo0.69474675
107MP0003868_abnormal_feces_composition0.69182323
108MP0004858_abnormal_nervous_system0.69008637
109MP0005448_abnormal_energy_balance0.68973856
110MP0004484_altered_response_of0.67182368
111MP0001666_abnormal_nutrient_absorption0.65450021
112MP0003091_abnormal_cell_migration0.64347799
113MP0001765_abnormal_ion_homeostasis0.64079723
114MP0002735_abnormal_chemical_nociception0.64033187
115MP0001661_extended_life_span0.63997826
116MP0009250_abnormal_appendicular_skeleto0.63411426
117MP0005023_abnormal_wound_healing0.61900580
118MP0010386_abnormal_urinary_bladder0.61755149
119MP0008872_abnormal_physiological_respon0.61191504
120MP0000266_abnormal_heart_morphology0.61189338
121MP0005390_skeleton_phenotype0.60875101
122MP0002138_abnormal_hepatobiliary_system0.60771996
123MP0002128_abnormal_blood_circulation0.60085474
124MP0000163_abnormal_cartilage_morphology0.59203857
125MP0000343_altered_response_to0.58974736
126MP0002734_abnormal_mechanical_nocicepti0.58254597
127MP0006054_spinal_hemorrhage0.57970267
128MP0001270_distended_abdomen0.56686137
129MP0003136_yellow_coat_color0.56174803
130MP0003567_abnormal_fetal_cardiomyocyte0.55875823
131MP0002295_abnormal_pulmonary_circulatio0.55468533
132MP0002168_other_aberrant_phenotype0.54666879
133MP0002133_abnormal_respiratory_system0.54582680
134MP0005388_respiratory_system_phenotype0.54582680
135MP0005535_abnormal_body_temperature0.53757017
136MP0005551_abnormal_eye_electrophysiolog0.52647688
137MP0009384_cardiac_valve_regurgitation0.52409663
138MP0001486_abnormal_startle_reflex0.52211358
139MP0009115_abnormal_fat_cell0.50995978
140MP0002127_abnormal_cardiovascular_syste0.50755176
141MP0006072_abnormal_retinal_apoptosis0.49565362
142MP0005166_decreased_susceptibility_to0.49152510
143MP0000428_abnormal_craniofacial_morphol0.48484616
144MP0003075_altered_response_to0.48214246
145MP0001879_abnormal_lymphatic_vessel0.47330383
146MP0003252_abnormal_bile_duct0.47286217
147MP0005646_abnormal_pituitary_gland0.47160409
148MP0000762_abnormal_tongue_morphology0.46811257
149MP0001614_abnormal_blood_vessel0.45837414

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)8.04645561
2Increased connective tissue (HP:0009025)7.70435605
3Type 1 muscle fiber predominance (HP:0003803)6.24623824
4Ankle contracture (HP:0006466)5.56846966
5Mildly elevated creatine phosphokinase (HP:0008180)5.35573676
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.29628437
7Muscle fiber inclusion bodies (HP:0100299)5.28941479
8Distal lower limb amyotrophy (HP:0008944)5.12310978
9Protrusio acetabuli (HP:0003179)5.12193556
10Broad metatarsal (HP:0001783)5.03862532
11Premature rupture of membranes (HP:0001788)5.02409749
12Difficulty climbing stairs (HP:0003551)4.99576033
13Abnormality of the calf musculature (HP:0001430)4.92601543
14Spinal rigidity (HP:0003306)4.39518682
15Calf muscle hypertrophy (HP:0008981)4.17079888
16Increased variability in muscle fiber diameter (HP:0003557)4.04281385
17Lower limb amyotrophy (HP:0007210)4.01033208
18Muscle hypertrophy of the lower extremities (HP:0008968)3.92623420
19Exercise-induced myalgia (HP:0003738)3.74811663
20Abnormality of skeletal muscle fiber size (HP:0012084)3.73053338
21Difficulty running (HP:0009046)3.72394166
22Ulnar deviation of the wrist (HP:0003049)3.61107994
23Slender build (HP:0001533)3.57700063
24Centrally nucleated skeletal muscle fibers (HP:0003687)3.56037964
25Aortic dissection (HP:0002647)3.51708109
26Round ear (HP:0100830)3.48515724
27EMG: myopathic abnormalities (HP:0003458)3.42557569
28Exercise-induced muscle cramps (HP:0003710)3.39211489
29Rimmed vacuoles (HP:0003805)3.37882296
30Hyperkalemia (HP:0002153)3.24524242
31Striae distensae (HP:0001065)3.20570378
32Limb-girdle muscle weakness (HP:0003325)3.18909599
33Hyporeflexia of lower limbs (HP:0002600)3.17202572
34Follicular hyperkeratosis (HP:0007502)3.13502399
35Asymmetric septal hypertrophy (HP:0001670)3.11330821
36Soft skin (HP:0000977)3.10668230
37Cerebral aneurysm (HP:0004944)3.08615653
38Subaortic stenosis (HP:0001682)3.05070428
39Abnormality of the left ventricular outflow tract (HP:0011103)3.05070428
40Nemaline bodies (HP:0003798)2.99485692
41Areflexia of lower limbs (HP:0002522)2.97459569
42Frequent falls (HP:0002359)2.95911829
43Absent phalangeal crease (HP:0006109)2.91397443
44Wrist flexion contracture (HP:0001239)2.90067757
45Mitral valve prolapse (HP:0001634)2.85093819
46Bundle branch block (HP:0011710)2.83337805
47Calcaneovalgus deformity (HP:0001848)2.80256358
48Dilatation of the ascending aorta (HP:0005111)2.79114370
49Shallow orbits (HP:0000586)2.78661768
50Sudden death (HP:0001699)2.76330745
51Malignant hyperthermia (HP:0002047)2.73734035
52Aortic aneurysm (HP:0004942)2.71482014
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.66351666
54Lipoatrophy (HP:0100578)2.63821979
55Generalized amyotrophy (HP:0003700)2.61991283
56Muscular dystrophy (HP:0003560)2.60457879
57Genetic anticipation (HP:0003743)2.59250998
58Malnutrition (HP:0004395)2.54155957
59Right ventricular cardiomyopathy (HP:0011663)2.53472626
60Distal lower limb muscle weakness (HP:0009053)2.49312916
61Hypoplastic ischia (HP:0003175)2.47800566
62Upper limb amyotrophy (HP:0009129)2.47073123
63Distal upper limb amyotrophy (HP:0007149)2.47073123
64Myoglobinuria (HP:0002913)2.46490031
65Fragile skin (HP:0001030)2.46021776
66Venous abnormality (HP:0002624)2.44908097
67EMG: neuropathic changes (HP:0003445)2.44044313
68Flat cornea (HP:0007720)2.42373357
69Abnormality of the ischium (HP:0003174)2.42311238
70Facial diplegia (HP:0001349)2.42138148
71Proximal amyotrophy (HP:0007126)2.42045510
72Abnormal finger flexion creases (HP:0006143)2.41189052
73Deformed tarsal bones (HP:0008119)2.41186397
74Myotonia (HP:0002486)2.41150029
75Atrial fibrillation (HP:0005110)2.39375220
76Limb-girdle muscle atrophy (HP:0003797)2.33906068
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33824298
78Fetal akinesia sequence (HP:0001989)2.32944504
79Bladder diverticulum (HP:0000015)2.32678914
80Syncope (HP:0001279)2.31926345
81Venous insufficiency (HP:0005293)2.30802120
82Generalized muscle weakness (HP:0003324)2.30590362
83Neoplasm of the heart (HP:0100544)2.28367692
84Ventricular tachycardia (HP:0004756)2.26838859
85Long clavicles (HP:0000890)2.25701458
86Gowers sign (HP:0003391)2.20454920
87Popliteal pterygium (HP:0009756)2.20439297
88Achilles tendon contracture (HP:0001771)2.18808559
89Neck muscle weakness (HP:0000467)2.18106289
90Primary atrial arrhythmia (HP:0001692)2.17867772
91Rectal prolapse (HP:0002035)2.16451388
92Weak cry (HP:0001612)2.15305549
93Heart block (HP:0012722)2.11991874
94Hypoventilation (HP:0002791)2.11931593
95Myopathic facies (HP:0002058)2.11629189
96Pelvic girdle muscle weakness (HP:0003749)2.11457362
97Atrophic scars (HP:0001075)2.10365683
98Abnormality of potassium homeostasis (HP:0011042)2.10100440
99Supraventricular arrhythmia (HP:0005115)2.10015366
100Congenital stationary night blindness (HP:0007642)2.09947241
101Abnormality of the neuromuscular junction (HP:0003398)2.08644270
102Fatigable weakness (HP:0003473)2.08644270
103Abnormality of proline metabolism (HP:0010907)2.07372670
104Hydroxyprolinuria (HP:0003080)2.07372670
105Supraventricular tachycardia (HP:0004755)2.05691787
106Duplicated collecting system (HP:0000081)2.05578891
107Scapular winging (HP:0003691)2.03839334
108Wormian bones (HP:0002645)2.01841971
109Shoulder girdle muscle weakness (HP:0003547)2.01469995
110Decreased circulating renin level (HP:0003351)2.01412729
111Hip contracture (HP:0003273)2.01286959
112Ventricular arrhythmia (HP:0004308)2.01040709
113Abnormality of the Achilles tendon (HP:0005109)2.00287182
114Muscle stiffness (HP:0003552)1.97416447
115Abnormality of the hip-girdle musculature (HP:0001445)1.96490126
116Abnormality of the musculature of the pelvis (HP:0001469)1.96490126
117Aneurysm (HP:0002617)1.95810770
118Ureteral duplication (HP:0000073)1.94739562
119Hyperextensible skin (HP:0000974)1.94609939
120Nonprogressive disorder (HP:0003680)1.92560111
121Limited hip movement (HP:0008800)1.92301111
122Distal arthrogryposis (HP:0005684)1.90995413
123Abnormal atrioventricular conduction (HP:0005150)1.90348638
124Thin bony cortex (HP:0002753)1.88319670
125Prolonged QT interval (HP:0001657)1.88276462
126Joint laxity (HP:0001388)1.87284820
127Gastrointestinal dysmotility (HP:0002579)1.87183998
128Waddling gait (HP:0002515)1.86017227
129Hypoalphalipoproteinemia (HP:0003233)1.85203591
130Lumbar hyperlordosis (HP:0002938)1.83882984
131Abnormality of the shoulder girdle musculature (HP:0001435)1.83568866
132Osteolytic defects of the hand bones (HP:0009699)1.83560637
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.83560637
134Pulmonary artery stenosis (HP:0004415)1.80821357
135Mitral stenosis (HP:0001718)1.79740999
136Difficulty walking (HP:0002355)1.78613614
137Rhabdomyolysis (HP:0003201)1.78447273
138Congenital sensorineural hearing impairment (HP:0008527)1.78373978
139Hypokalemia (HP:0002900)1.78286651
140Abnormality of the pubic bones (HP:0003172)1.78234330
141Respiratory insufficiency due to muscle weakness (HP:0002747)1.78015877
142Bulbar palsy (HP:0001283)1.76477497
143Elbow flexion contracture (HP:0002987)1.75049823
144Short nail (HP:0001799)1.72680760
145Dilated cardiomyopathy (HP:0001644)1.70990188
146Abnormality of the calcaneus (HP:0008364)1.66749452
147Ventricular fibrillation (HP:0001663)1.64485986
148Abnormal EKG (HP:0003115)1.62038731
149Hyperventilation (HP:0002883)1.58502375
150Hyperglycinuria (HP:0003108)1.58494859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.02159098
2OBSCN4.95143480
3TTN4.73759457
4EPHA33.53634603
5RIPK13.36950076
6MUSK3.05481582
7TRIB32.88257410
8EPHB12.71926496
9PHKG12.22010902
10PHKG22.22010902
11DMPK2.07429093
12SIK11.90285264
13ACVR1B1.87112522
14MOS1.83086527
15DDR21.80002282
16PKN21.76625850
17ERN11.75399279
18MAP3K71.68923377
19PDGFRA1.65499242
20MST1R1.43056206
21FER1.40115511
22LATS11.37414573
23LMTK21.37020487
24BMX1.31110717
25TGFBR21.29825920
26MYLK1.29683347
27FGFR31.28323185
28GRK11.26525368
29CAMK1D1.21046438
30PINK11.18542108
31PDK21.07648363
32NEK11.07599377
33MAP2K31.05985442
34STK38L1.05796821
35NME11.05021184
36MAP3K61.01890175
37TSSK60.99982696
38BMPR1B0.99083204
39INSRR0.99043553
40EEF2K0.97533403
41ICK0.94045930
42PIK3CG0.93635752
43PDK40.90531391
44PDK30.90531391
45PRKG20.90134270
46ERBB40.88800498
47PAK20.85749566
48MAP2K60.85512128
49CASK0.84915766
50MTOR0.84070679
51CAMK1G0.83765999
52MAP3K30.81209096
53PRKAA10.73668179
54CAMK10.73376454
55TIE10.73292311
56ROCK10.73135255
57MAPK130.72590482
58JAK10.72312941
59PTK60.71103796
60AKT20.67897819
61BCKDK0.67700761
62PIK3CA0.67230166
63MAPK150.66373491
64RPS6KB20.66334664
65SGK4940.65742819
66SGK2230.65742819
67MAPKAPK30.65456122
68PTK2B0.65032360
69MET0.64482192
70IRAK10.64262070
71MARK10.63797831
72NEK20.63275868
73MAP3K130.62313529
74HIPK20.61646560
75TLK10.61076888
76ROCK20.59736986
77SGK20.59299678
78PDGFRB0.59218258
79ADRBK20.58849049
80MAP2K10.57548248
81CSK0.57333022
82CAMK2D0.57143370
83ILK0.56627639
84STK380.56341775
85TNK20.56116503
86PRKAA20.54758926
87MAPK120.54133640
88PRKG10.53873322
89TRPM70.53475300
90NLK0.52172572
91PRKCH0.52006477
92FGFR10.52004449
93RET0.51445590
94MARK30.49583193
95GSK3A0.49529024
96PRKD10.48755997
97MAPK70.46789704
98MAP4K20.45824532
99CAMK2A0.42961713
100TNIK0.42211383
101PKN10.40839983
102PDPK10.40206974
103MAPK110.40089154
104RPS6KA60.39354852
105KDR0.39181926
106RPS6KC10.39134866
107RPS6KL10.39134866
108DAPK30.39026804
109OXSR10.38427345
110PAK60.37925675
111ADRBK10.37882013
112PRKACA0.36911938
113PTK20.36026741
114JAK20.35929504
115ZAK0.35468098
116CAMK40.34768966
117LATS20.34742072
118DAPK20.33503349
119SGK30.32294459
120MAPK40.31994737
121PAK30.31396263
122FLT30.30527268
123RPS6KB10.29282071
124FRK0.29178832
125PRKCE0.29072567
126CDK60.28796453
127RPS6KA30.28685176
128STK110.28564968
129RPS6KA20.28478022
130MARK20.27173425
131MAP3K100.26466243
132STK30.26093694
133CAMK2G0.24866835
134KIT0.24806880
135RPS6KA10.24648124
136PRKACG0.23704078
137AKT30.23611504
138CAMK2B0.22517006
139CDC42BPA0.22170829
140MAPK10.22118456
141MAP2K20.21931551
142EPHA20.21900642
143SGK10.21862904
144FGFR20.21774322
145MELK0.21545143
146PRKACB0.20607498

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.77926329
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.55336380
3Dilated cardiomyopathy_Homo sapiens_hsa054143.43007381
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.16997921
5Protein digestion and absorption_Homo sapiens_hsa049742.63906117
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36601825
7Circadian rhythm_Homo sapiens_hsa047102.32749727
8Focal adhesion_Homo sapiens_hsa045102.27737055
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22993324
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.18682137
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08194035
12Cardiac muscle contraction_Homo sapiens_hsa042601.82524001
13Fat digestion and absorption_Homo sapiens_hsa049751.74701297
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61112313
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.59257133
16Viral myocarditis_Homo sapiens_hsa054161.58759799
17Arginine and proline metabolism_Homo sapiens_hsa003301.58394656
18Histidine metabolism_Homo sapiens_hsa003401.55330169
19Linoleic acid metabolism_Homo sapiens_hsa005911.53166137
20Insulin resistance_Homo sapiens_hsa049311.48076731
21Dorso-ventral axis formation_Homo sapiens_hsa043201.43355847
22Amoebiasis_Homo sapiens_hsa051461.42904503
23Tryptophan metabolism_Homo sapiens_hsa003801.40504427
24Renin-angiotensin system_Homo sapiens_hsa046141.36523509
25Fatty acid degradation_Homo sapiens_hsa000711.34049216
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32423515
27Propanoate metabolism_Homo sapiens_hsa006401.30360993
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29183992
29PPAR signaling pathway_Homo sapiens_hsa033201.28962321
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.25531654
31Malaria_Homo sapiens_hsa051441.23747663
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22815886
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21989955
34Vitamin digestion and absorption_Homo sapiens_hsa049771.21365986
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21005285
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20266743
37Renin secretion_Homo sapiens_hsa049241.18825908
38Proteoglycans in cancer_Homo sapiens_hsa052051.17213584
39Type II diabetes mellitus_Homo sapiens_hsa049301.14876074
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.14602347
41Carbon metabolism_Homo sapiens_hsa012001.13678072
42Chemical carcinogenesis_Homo sapiens_hsa052041.12345890
43AMPK signaling pathway_Homo sapiens_hsa041521.11141342
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10117610
45Taste transduction_Homo sapiens_hsa047421.08063497
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06898180
47Gastric acid secretion_Homo sapiens_hsa049711.05511093
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04264927
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.03272109
50Insulin signaling pathway_Homo sapiens_hsa049101.00949136
51Retinol metabolism_Homo sapiens_hsa008301.00737295
52Oxytocin signaling pathway_Homo sapiens_hsa049210.99852015
53Pancreatic secretion_Homo sapiens_hsa049720.99180617
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98511781
55Phototransduction_Homo sapiens_hsa047440.97638460
56Starch and sucrose metabolism_Homo sapiens_hsa005000.97579665
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95438536
58Fructose and mannose metabolism_Homo sapiens_hsa000510.94488828
59Glycerolipid metabolism_Homo sapiens_hsa005610.94027797
60Glucagon signaling pathway_Homo sapiens_hsa049220.92745173
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92422374
62Fatty acid metabolism_Homo sapiens_hsa012120.92177598
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90493768
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87370680
65HIF-1 signaling pathway_Homo sapiens_hsa040660.86953888
66Olfactory transduction_Homo sapiens_hsa047400.86628200
67MAPK signaling pathway_Homo sapiens_hsa040100.84782058
68Nitrogen metabolism_Homo sapiens_hsa009100.84372604
69Prion diseases_Homo sapiens_hsa050200.83805797
70Small cell lung cancer_Homo sapiens_hsa052220.83262935
71Biosynthesis of amino acids_Homo sapiens_hsa012300.82674066
72Adherens junction_Homo sapiens_hsa045200.82619617
73Notch signaling pathway_Homo sapiens_hsa043300.82421043
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81474642
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81366318
76Toxoplasmosis_Homo sapiens_hsa051450.79510187
77Lysine degradation_Homo sapiens_hsa003100.78995378
78Caffeine metabolism_Homo sapiens_hsa002320.78967305
79Ovarian steroidogenesis_Homo sapiens_hsa049130.78082163
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77421102
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.77307333
82Arginine biosynthesis_Homo sapiens_hsa002200.77060288
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76426022
84MicroRNAs in cancer_Homo sapiens_hsa052060.75405834
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74175813
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.73672936
87Calcium signaling pathway_Homo sapiens_hsa040200.73396760
88beta-Alanine metabolism_Homo sapiens_hsa004100.73369657
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72035501
90Galactose metabolism_Homo sapiens_hsa000520.71992392
91Arachidonic acid metabolism_Homo sapiens_hsa005900.71684092
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70196124
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69931877
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67665502
95GABAergic synapse_Homo sapiens_hsa047270.66138022
96Mineral absorption_Homo sapiens_hsa049780.66035368
97Serotonergic synapse_Homo sapiens_hsa047260.65618484
98Platelet activation_Homo sapiens_hsa046110.62126461
99Fatty acid biosynthesis_Homo sapiens_hsa000610.60839953
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59848670
101Long-term depression_Homo sapiens_hsa047300.58751207
102Estrogen signaling pathway_Homo sapiens_hsa049150.58640272
103Complement and coagulation cascades_Homo sapiens_hsa046100.58566253
104mTOR signaling pathway_Homo sapiens_hsa041500.58493563
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58075627
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57585839
107Phenylalanine metabolism_Homo sapiens_hsa003600.56687879
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55699627
109Circadian entrainment_Homo sapiens_hsa047130.55413664
110TGF-beta signaling pathway_Homo sapiens_hsa043500.54808525
111Bile secretion_Homo sapiens_hsa049760.54351886
112Morphine addiction_Homo sapiens_hsa050320.53996847
113GnRH signaling pathway_Homo sapiens_hsa049120.53556679
114Salivary secretion_Homo sapiens_hsa049700.52623131
115Ether lipid metabolism_Homo sapiens_hsa005650.51649560
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50836162
117Insulin secretion_Homo sapiens_hsa049110.50739048
118Salmonella infection_Homo sapiens_hsa051320.50413783
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48946797
120cAMP signaling pathway_Homo sapiens_hsa040240.48799087
121Acute myeloid leukemia_Homo sapiens_hsa052210.48746929
122Chronic myeloid leukemia_Homo sapiens_hsa052200.46837288
123Pyruvate metabolism_Homo sapiens_hsa006200.46492524
124Tyrosine metabolism_Homo sapiens_hsa003500.46113826
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45868750
126FoxO signaling pathway_Homo sapiens_hsa040680.45725489
127Tight junction_Homo sapiens_hsa045300.44567928
128Melanoma_Homo sapiens_hsa052180.43068999
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43053330
130Sulfur relay system_Homo sapiens_hsa041220.42715882
131Peroxisome_Homo sapiens_hsa041460.42544868
132Pathways in cancer_Homo sapiens_hsa052000.41921662
133Hedgehog signaling pathway_Homo sapiens_hsa043400.41227255
134Butanoate metabolism_Homo sapiens_hsa006500.41081492
135Gap junction_Homo sapiens_hsa045400.40562884
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40345702
137Bladder cancer_Homo sapiens_hsa052190.40102792
138Glutamatergic synapse_Homo sapiens_hsa047240.39020482
139Renal cell carcinoma_Homo sapiens_hsa052110.37139064
140Hippo signaling pathway_Homo sapiens_hsa043900.36861588
141ABC transporters_Homo sapiens_hsa020100.34552791
142Cholinergic synapse_Homo sapiens_hsa047250.34520388

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