HMG20A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.90147067
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.84951195
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.77964239
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69703632
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66927581
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55173201
7synaptic vesicle exocytosis (GO:0016079)4.43932864
8DNA double-strand break processing (GO:0000729)4.43435809
9vocalization behavior (GO:0071625)4.32262323
10positive regulation of synapse maturation (GO:0090129)4.28390229
11protein localization to synapse (GO:0035418)4.27755484
12locomotory exploration behavior (GO:0035641)4.24785190
13regulation of synapse structural plasticity (GO:0051823)4.23638824
14regulation of synaptic vesicle exocytosis (GO:2000300)4.11969376
15regulation of glutamate receptor signaling pathway (GO:1900449)4.09592631
16layer formation in cerebral cortex (GO:0021819)4.00149103
17glutamate secretion (GO:0014047)3.89724124
18pre-miRNA processing (GO:0031054)3.88390238
19DNA damage response, detection of DNA damage (GO:0042769)3.83203001
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.82924447
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82924447
22nuclear pore organization (GO:0006999)3.81711748
23establishment of integrated proviral latency (GO:0075713)3.81181486
24negative regulation of DNA recombination (GO:0045910)3.80556483
25neuron cell-cell adhesion (GO:0007158)3.79314435
26exploration behavior (GO:0035640)3.79055698
27protein localization to kinetochore (GO:0034501)3.72946957
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69148957
29nuclear pore complex assembly (GO:0051292)3.68628028
30neurotransmitter-gated ion channel clustering (GO:0072578)3.64496261
31regulation of helicase activity (GO:0051095)3.64398617
32regulation of synaptic vesicle transport (GO:1902803)3.63038617
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56445269
34negative regulation of sodium ion transport (GO:0010766)3.46849262
35mitotic sister chromatid cohesion (GO:0007064)3.45962917
36regulation of neuronal synaptic plasticity (GO:0048168)3.44299212
37L-serine metabolic process (GO:0006563)3.43708426
38histone H2A acetylation (GO:0043968)3.43632259
39postsynaptic membrane organization (GO:0001941)3.43613587
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42985422
41response to pheromone (GO:0019236)3.41210154
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.40479318
43innervation (GO:0060384)3.36209593
44attachment of spindle microtubules to kinetochore (GO:0008608)3.35190499
45ribosome assembly (GO:0042255)3.32739309
46DNA ligation (GO:0006266)3.31937033
47glutamate receptor signaling pathway (GO:0007215)3.29197881
48auditory behavior (GO:0031223)3.28314674
49synaptic transmission, glutamatergic (GO:0035249)3.26846355
50regulation of autophagic vacuole assembly (GO:2000785)3.26077086
51negative regulation of organelle assembly (GO:1902116)3.25358640
52negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24868620
53neurotransmitter secretion (GO:0007269)3.23997033
54dendritic spine morphogenesis (GO:0060997)3.22507109
55mitotic spindle checkpoint (GO:0071174)3.21554985
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20057364
57DNA topological change (GO:0006265)3.18852854
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.18739289
59cerebellar Purkinje cell differentiation (GO:0021702)3.18591131
60regulation of synapse maturation (GO:0090128)3.18420073
61spindle checkpoint (GO:0031577)3.18099287
62hyperosmotic salinity response (GO:0042538)3.17126709
63sodium ion export (GO:0071436)3.16594330
64chromatin remodeling at centromere (GO:0031055)3.16230085
65CENP-A containing nucleosome assembly (GO:0034080)3.14863536
66peptidyl-arginine omega-N-methylation (GO:0035247)3.12370450
67protein localization to chromosome, centromeric region (GO:0071459)3.12323313
68cell communication by electrical coupling (GO:0010644)3.12275801
69positive regulation of membrane potential (GO:0045838)3.11887538
70synaptic vesicle endocytosis (GO:0048488)3.11821892
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.11191797
72negative regulation of sister chromatid segregation (GO:0033046)3.11191797
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11191797
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11191797
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11191797
76negative regulation of chromosome segregation (GO:0051985)3.11134427
77long-term memory (GO:0007616)3.08416970
78histone H4-K8 acetylation (GO:0043982)3.08100704
79histone H4-K5 acetylation (GO:0043981)3.08100704
80positive regulation of mitochondrial fission (GO:0090141)3.08065422
81establishment of mitochondrion localization (GO:0051654)3.06426664
82long-term synaptic potentiation (GO:0060291)3.04702979
83double-strand break repair via nonhomologous end joining (GO:0006303)3.03948932
84non-recombinational repair (GO:0000726)3.03948932
85neuron-neuron synaptic transmission (GO:0007270)3.03451995
86cullin deneddylation (GO:0010388)3.02819059
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01257321
88mitotic spindle assembly checkpoint (GO:0007094)3.00852378
89DNA catabolic process, exonucleolytic (GO:0000738)2.99270705
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98398923
91spindle assembly checkpoint (GO:0071173)2.98174635
92mechanosensory behavior (GO:0007638)2.96969654
93establishment of nucleus localization (GO:0040023)2.96223832
94ncRNA catabolic process (GO:0034661)2.96051648
95tRNA aminoacylation for protein translation (GO:0006418)2.95413013
96regulation of sister chromatid segregation (GO:0033045)2.95219576
97regulation of mitotic sister chromatid separation (GO:0010965)2.95219576
98regulation of mitotic sister chromatid segregation (GO:0033047)2.95219576
99mitotic metaphase plate congression (GO:0007080)2.95109045
100DNA integration (GO:0015074)2.93986967
101membrane hyperpolarization (GO:0060081)2.93539352
102peptidyl-arginine methylation (GO:0018216)2.93197359
103peptidyl-arginine N-methylation (GO:0035246)2.93197359
104IMP biosynthetic process (GO:0006188)2.92410825
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91681447
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91551938
107tRNA aminoacylation (GO:0043039)2.91021265
108amino acid activation (GO:0043038)2.91021265
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90525561
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90525561
111DNA unwinding involved in DNA replication (GO:0006268)2.89198459
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88320885
113regulation of neurotransmitter secretion (GO:0046928)2.86815077
114DNA replication-dependent nucleosome organization (GO:0034723)2.84645692
115DNA replication-dependent nucleosome assembly (GO:0006335)2.84645692
116cellular potassium ion homeostasis (GO:0030007)2.84313403
117DNA strand elongation involved in DNA replication (GO:0006271)2.83632033
118response to auditory stimulus (GO:0010996)2.83481752
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.83196819
120regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82536449
121regulation of mitotic spindle checkpoint (GO:1903504)2.82536449
122regulation of synaptic plasticity (GO:0048167)2.82220927
123formation of translation preinitiation complex (GO:0001731)2.81905373
124histone arginine methylation (GO:0034969)2.81409169
125regulation of chromosome segregation (GO:0051983)2.80456975
126replication fork processing (GO:0031297)2.78715232
127regulation of postsynaptic membrane potential (GO:0060078)2.78677339
128dendrite morphogenesis (GO:0048813)2.77334199
129positive regulation of myoblast differentiation (GO:0045663)2.76162369
130pore complex assembly (GO:0046931)2.75572571
131synapse assembly (GO:0007416)2.75317561
132prepulse inhibition (GO:0060134)2.74402418
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74292623
134telomere maintenance via telomerase (GO:0007004)2.73453613
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73235776
136kinetochore assembly (GO:0051382)2.72983855
137DNA strand elongation (GO:0022616)2.72794466
138neuron recognition (GO:0008038)2.72652845
139sister chromatid segregation (GO:0000819)2.72634725
140histone exchange (GO:0043486)2.72437300
141gamma-aminobutyric acid signaling pathway (GO:0007214)2.72240854
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72184266
143metaphase plate congression (GO:0051310)2.71951094
144DNA replication-independent nucleosome assembly (GO:0006336)2.70880503
145DNA replication-independent nucleosome organization (GO:0034724)2.70880503
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.69971828
147regulation of DNA endoreduplication (GO:0032875)2.68880334
148visual learning (GO:0008542)2.68535122
149protein localization to chromosome (GO:0034502)2.67850717
150kinetochore organization (GO:0051383)2.67650254
151negative regulation of mRNA processing (GO:0050686)2.67647319
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.67245021
153neuromuscular process controlling balance (GO:0050885)2.66526436
154regulation of neurotransmitter transport (GO:0051588)2.66264100
155negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65383438
156negative regulation of translation, ncRNA-mediated (GO:0040033)2.65383438
157regulation of translation, ncRNA-mediated (GO:0045974)2.65383438
158central nervous system projection neuron axonogenesis (GO:0021952)2.65323173
159pyrimidine nucleobase catabolic process (GO:0006208)2.63817961
160mitotic sister chromatid segregation (GO:0000070)2.62938704
161learning (GO:0007612)2.60704901
162axonal fasciculation (GO:0007413)2.60361309
163mismatch repair (GO:0006298)2.60325682
164positive regulation of histone H3-K4 methylation (GO:0051571)2.59075958
165mitochondrial RNA metabolic process (GO:0000959)2.58969831
166mitotic nuclear envelope disassembly (GO:0007077)2.58875333
167activation of protein kinase A activity (GO:0034199)2.58821462
168negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58412788
169RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58362210
170negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58170835
171regulation of centriole replication (GO:0046599)2.58139516
172maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58021757
173negative regulation of microtubule polymerization (GO:0031115)2.57693673
174regulation of mRNA splicing, via spliceosome (GO:0048024)2.56806048
175protein deneddylation (GO:0000338)2.56528078
176presynaptic membrane assembly (GO:0097105)2.56482490
177spermatid nucleus differentiation (GO:0007289)2.55760200
178resolution of meiotic recombination intermediates (GO:0000712)2.55634756
179regulation of dendritic spine morphogenesis (GO:0061001)2.54963507
180membrane depolarization during action potential (GO:0086010)2.54837182
181visual behavior (GO:0007632)2.54046536
182transmission of nerve impulse (GO:0019226)2.53102080
183dopamine receptor signaling pathway (GO:0007212)2.52747146
184neurotransmitter transport (GO:0006836)2.52113689
185proline transport (GO:0015824)2.51465401
186behavioral defense response (GO:0002209)2.50885913
187behavioral fear response (GO:0001662)2.50885913
188regulation of vesicle fusion (GO:0031338)2.50714641
189cell migration in hindbrain (GO:0021535)2.50307566
190peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.49421045
191membrane depolarization (GO:0051899)2.49196950
192striatum development (GO:0021756)2.48524013
193positive regulation of synaptic transmission (GO:0050806)2.46535792
194G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46049886
195regulation of dendrite morphogenesis (GO:0048814)2.45609084
196synaptic vesicle transport (GO:0048489)2.44601062
197establishment of synaptic vesicle localization (GO:0097480)2.44601062
198neuronal action potential propagation (GO:0019227)2.44519588
199positive regulation of cardiac muscle cell differentiation (GO:2000727)2.43819589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.07380759
2EZH2_22144423_ChIP-Seq_EOC_Human4.88000907
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58358953
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.37814038
5GBX2_23144817_ChIP-Seq_PC3_Human3.37322076
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21544765
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95705064
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.95061222
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93764411
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90630836
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.89741363
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87874307
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82288793
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.72856906
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71374327
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.71083669
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65694130
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63317289
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62898331
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62898331
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52123815
22REST_21632747_ChIP-Seq_MESCs_Mouse2.51282585
23* ELK1_19687146_ChIP-ChIP_HELA_Human2.46568352
24DROSHA_22980978_ChIP-Seq_HELA_Human2.46003300
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45399981
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.44730952
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.42442061
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41636650
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41337950
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39779779
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37775664
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36796405
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.34176493
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32475631
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31986571
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30632044
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.29034406
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26159031
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25795352
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.20000859
41* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19013607
42SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15888865
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15571415
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12572357
45* ETS1_20019798_ChIP-Seq_JURKAT_Human2.07665908
46* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05565936
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99902334
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.97442759
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95640312
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94009259
51AR_21572438_ChIP-Seq_LNCaP_Human1.93086744
52VDR_23849224_ChIP-Seq_CD4+_Human1.91900842
53EWS_26573619_Chip-Seq_HEK293_Human1.91047793
54FOXP3_21729870_ChIP-Seq_TREG_Human1.89697885
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89266235
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83999060
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83806564
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83386426
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82342429
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82228223
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74452223
62* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70268027
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.67379191
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67371082
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58390924
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.58284431
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56767175
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54293419
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50426492
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.49958015
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49697517
72SMAD4_21799915_ChIP-Seq_A2780_Human1.47966805
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47861774
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47218954
75MYC_18940864_ChIP-ChIP_HL60_Human1.45593058
76* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42992429
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42859331
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41783758
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41566838
80CIITA_25753668_ChIP-Seq_RAJI_Human1.40971775
81* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40338930
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40208395
83TTF2_22483619_ChIP-Seq_HELA_Human1.39535425
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38790349
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38243726
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37156171
87GABP_19822575_ChIP-Seq_HepG2_Human1.37029892
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33546411
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33337621
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31316460
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31080891
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30438691
93IGF1R_20145208_ChIP-Seq_DFB_Human1.30390537
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.29995411
95* SOX2_16153702_ChIP-ChIP_HESCs_Human1.29622370
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28971483
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26596675
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.26499805
99SCL_19346495_ChIP-Seq_HPC-7_Human1.26386010
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26058923
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25922682
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.25841450
103ZNF274_21170338_ChIP-Seq_K562_Hela1.25364042
104* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24754764
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23957903
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.23879788
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23514631
108* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22349906
109P300_19829295_ChIP-Seq_ESCs_Human1.22283172
110* NANOG_16153702_ChIP-ChIP_HESCs_Human1.21679334
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20937101
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20759136
113AR_19668381_ChIP-Seq_PC3_Human1.20625848
114RNF2_27304074_Chip-Seq_NSC_Mouse1.20494198
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.20198111
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.18053361
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17836382
118DCP1A_22483619_ChIP-Seq_HELA_Human1.17182356
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.15844217
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15525381
121* SMAD3_21741376_ChIP-Seq_EPCs_Human1.15227713
122XRN2_22483619_ChIP-Seq_HELA_Human1.13993684
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13198858
124ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13158927
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13107599
126IRF1_19129219_ChIP-ChIP_H3396_Human1.12241881
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11861094
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11599395
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11125141
130VDR_22108803_ChIP-Seq_LS180_Human1.11090725
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10933379
132ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10705720
133* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10598511
134TAF15_26573619_Chip-Seq_HEK293_Human1.10424817
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09966556
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09851234
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08906664
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.06629009
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05720946
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05122583
141POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04762083
142STAT3_23295773_ChIP-Seq_U87_Human1.03684093
143* AR_25329375_ChIP-Seq_VCAP_Human1.02924666
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02456551
145* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01126771
146RUNX_20019798_ChIP-Seq_JUKART_Human1.01066310
147KDM2B_26808549_Chip-Seq_K562_Human1.00503041
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99932923
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99178263
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99156883
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98238062
152EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97962485
153FUS_26573619_Chip-Seq_HEK293_Human0.97095174
154AHR_22903824_ChIP-Seq_MCF-7_Human0.97070319
155* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97060688
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96313110
157* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95999494
158KDM5A_27292631_Chip-Seq_BREAST_Human0.95897456
159CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95887469
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95598005
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95100151
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95100151
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.95006543
164SOX9_26525672_Chip-Seq_HEART_Mouse0.94874852
165CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94676245
166TCF4_23295773_ChIP-Seq_U87_Human0.94559353
167BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94488679
168GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94062774
169MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93789726
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.93062452
171SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92160566
172GATA1_26923725_Chip-Seq_HPCs_Mouse0.92070809
173* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91272412
174* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91229892
175AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91080076
176POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89911232
177TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88895597
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88391991
179* SOX17_20123909_ChIP-Seq_XEN_Mouse0.86419442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43996940
2MP0003635_abnormal_synaptic_transmissio3.38777505
3MP0003880_abnormal_central_pattern3.30015088
4MP0008058_abnormal_DNA_repair3.28466920
5MP0008877_abnormal_DNA_methylation3.14823000
6MP0010094_abnormal_chromosome_stability3.06658164
7MP0003122_maternal_imprinting2.68856151
8MP0002063_abnormal_learning/memory/cond2.66029951
9MP0005423_abnormal_somatic_nervous2.60143602
10MP0003111_abnormal_nucleus_morphology2.56992524
11MP0009745_abnormal_behavioral_response2.54012377
12MP0003787_abnormal_imprinting2.46092447
13MP0004270_analgesia2.45396013
14MP0002822_catalepsy2.41456937
15MP0004957_abnormal_blastocyst_morpholog2.40312875
16MP0003693_abnormal_embryo_hatching2.38823434
17MP0002064_seizures2.36435807
18MP0008057_abnormal_DNA_replication2.27526187
19MP0001968_abnormal_touch/_nociception2.25790097
20MP0002102_abnormal_ear_morphology2.20427406
21MP0002572_abnormal_emotion/affect_behav2.17392454
22MP0001486_abnormal_startle_reflex2.15116150
23MP0008932_abnormal_embryonic_tissue2.08730147
24MP0008569_lethality_at_weaning2.01698369
25MP0003567_abnormal_fetal_cardiomyocyte1.99952678
26MP0009046_muscle_twitch1.98424730
27MP0000778_abnormal_nervous_system1.95460569
28MP0002272_abnormal_nervous_system1.94502171
29MP0003283_abnormal_digestive_organ1.92886142
30MP0003077_abnormal_cell_cycle1.92647751
31MP0003121_genomic_imprinting1.89356751
32MP0002184_abnormal_innervation1.84162433
33MP0002736_abnormal_nociception_after1.79817444
34MP0002734_abnormal_mechanical_nocicepti1.77099673
35MP0005187_abnormal_penis_morphology1.76579657
36MP0005551_abnormal_eye_electrophysiolog1.76215122
37MP0003718_maternal_effect1.74123482
38MP0001188_hyperpigmentation1.67398441
39MP0005646_abnormal_pituitary_gland1.67346660
40MP0003879_abnormal_hair_cell1.62484072
41MP0004811_abnormal_neuron_physiology1.62249813
42MP0000516_abnormal_urinary_system1.61287930
43MP0005367_renal/urinary_system_phenotyp1.61287930
44MP0009697_abnormal_copulation1.60866313
45MP0003890_abnormal_embryonic-extraembry1.60053319
46MP0002067_abnormal_sensory_capabilities1.57786170
47MP0002557_abnormal_social/conspecific_i1.54498161
48MP0006035_abnormal_mitochondrial_morpho1.51804424
49MP0008007_abnormal_cellular_replicative1.49022476
50MP0003136_yellow_coat_color1.47873557
51MP0000631_abnormal_neuroendocrine_gland1.44404234
52MP0000955_abnormal_spinal_cord1.42099827
53MP0001293_anophthalmia1.41398531
54MP0002882_abnormal_neuron_morphology1.40049851
55MP0001502_abnormal_circadian_rhythm1.39200823
56MP0009672_abnormal_birth_weight1.36648557
57MP0004924_abnormal_behavior1.36560131
58MP0005386_behavior/neurological_phenoty1.36560131
59MP0000372_irregular_coat_pigmentation1.36029169
60MP0005394_taste/olfaction_phenotype1.35673343
61MP0005499_abnormal_olfactory_system1.35673343
62MP0001984_abnormal_olfaction1.32312129
63MP0000569_abnormal_digit_pigmentation1.29431010
64MP0001529_abnormal_vocalization1.27902795
65MP0002735_abnormal_chemical_nociception1.26663829
66MP0005409_darkened_coat_color1.26317924
67MP0002084_abnormal_developmental_patter1.25626288
68MP0003119_abnormal_digestive_system1.25553843
69MP0009703_decreased_birth_body1.24429642
70MP0002638_abnormal_pupillary_reflex1.24277848
71MP0003937_abnormal_limbs/digits/tail_de1.24138489
72MP0002396_abnormal_hematopoietic_system1.23480172
73MP0001697_abnormal_embryo_size1.23389808
74MP0002733_abnormal_thermal_nociception1.22968905
75MP0004197_abnormal_fetal_growth/weight/1.21966280
76MP0002234_abnormal_pharynx_morphology1.21849799
77MP0000534_abnormal_ureter_morphology1.19526187
78MP0003221_abnormal_cardiomyocyte_apopto1.18805487
79MP0001970_abnormal_pain_threshold1.17694004
80MP0002090_abnormal_vision1.17534068
81MP0002233_abnormal_nose_morphology1.17430863
82MP0002152_abnormal_brain_morphology1.17104014
83MP0001730_embryonic_growth_arrest1.16261454
84MP0000751_myopathy1.15364517
85MP0005380_embryogenesis_phenotype1.15155514
86MP0001672_abnormal_embryogenesis/_devel1.15155514
87MP0006276_abnormal_autonomic_nervous1.15077129
88MP0003786_premature_aging1.13978427
89MP0002085_abnormal_embryonic_tissue1.13237126
90MP0002938_white_spotting1.12850088
91MP0004885_abnormal_endolymph1.12024407
92MP0006292_abnormal_olfactory_placode1.11197234
93MP0005075_abnormal_melanosome_morpholog1.10381924
94MP0001501_abnormal_sleep_pattern1.09007466
95MP0008995_early_reproductive_senescence1.08141041
96MP0003646_muscle_fatigue1.07699813
97MP0000537_abnormal_urethra_morphology1.06452092
98MP0001929_abnormal_gametogenesis1.06014091
99MP0003315_abnormal_perineum_morphology1.05443807
100MP0001661_extended_life_span1.04958762
101MP0002066_abnormal_motor_capabilities/c1.04492869
102MP0003984_embryonic_growth_retardation1.02746835
103MP0004145_abnormal_muscle_electrophysio1.02641873
104MP0001177_atelectasis1.02310783
105MP0000350_abnormal_cell_proliferation1.01874124
106MP0004085_abnormal_heartbeat1.01296984
107MP0002088_abnormal_embryonic_growth/wei1.01246743
108MP0008961_abnormal_basal_metabolism0.99381309
109MP0010234_abnormal_vibrissa_follicle0.98224356
110MP0005171_absent_coat_pigmentation0.97975231
111MP0002909_abnormal_adrenal_gland0.97701929
112MP0005253_abnormal_eye_physiology0.97398278
113MP0004215_abnormal_myocardial_fiber0.97081767
114MP0009780_abnormal_chondrocyte_physiolo0.96532917
115MP0004858_abnormal_nervous_system0.96110942
116MP0002752_abnormal_somatic_nervous0.95758278
117MP0002210_abnormal_sex_determination0.94438011
118MP0004084_abnormal_cardiac_muscle0.93275594
119MP0003942_abnormal_urinary_system0.93062721
120MP0002080_prenatal_lethality0.92925150
121MP0000358_abnormal_cell_content/0.92602318
122MP0001286_abnormal_eye_development0.91556173
123MP0005645_abnormal_hypothalamus_physiol0.91388219
124MP0010030_abnormal_orbit_morphology0.91121153
125MP0002751_abnormal_autonomic_nervous0.90973460
126MP0001145_abnormal_male_reproductive0.90923347
127MP0003698_abnormal_male_reproductive0.90712625
128MP0003123_paternal_imprinting0.88947058
129MP0003137_abnormal_impulse_conducting0.88573321
130MP0003755_abnormal_palate_morphology0.88036253
131MP0010352_gastrointestinal_tract_polyps0.87726708
132MP0008789_abnormal_olfactory_epithelium0.87586074
133MP0003861_abnormal_nervous_system0.86743214
134MP0000647_abnormal_sebaceous_gland0.86263800
135MP0001905_abnormal_dopamine_level0.85650377
136MP0003943_abnormal_hepatobiliary_system0.84701668
137MP0000653_abnormal_sex_gland0.84558985
138MP0001299_abnormal_eye_distance/0.83976986
139MP0006072_abnormal_retinal_apoptosis0.83862773
140MP0004233_abnormal_muscle_weight0.82966116
141MP0000566_synostosis0.82292622
142MP0001963_abnormal_hearing_physiology0.81991735
143MP0004134_abnormal_chest_morphology0.80808384
144MP0003385_abnormal_body_wall0.80040295
145MP0002697_abnormal_eye_size0.78647295
146MP0001440_abnormal_grooming_behavior0.76427379
147MP0002653_abnormal_ependyma_morphology0.75871315
148MP0000049_abnormal_middle_ear0.75621476
149MP0004484_altered_response_of0.75593294
150MP0002229_neurodegeneration0.74570955
151MP0010368_abnormal_lymphatic_system0.73136596
152MP0003633_abnormal_nervous_system0.72233461
153MP0001348_abnormal_lacrimal_gland0.69859042
154MP0004142_abnormal_muscle_tone0.68622016
155MP0002081_perinatal_lethality0.68135684
156MP0002069_abnormal_eating/drinking_beha0.67473898
157MP0002249_abnormal_larynx_morphology0.66624596
158MP0005195_abnormal_posterior_eye0.65013304
159MP0000026_abnormal_inner_ear0.64830715
160MP0003935_abnormal_craniofacial_develop0.64828415
161MP0003631_nervous_system_phenotype0.64666989
162MP0008872_abnormal_physiological_respon0.64070232
163MP0010769_abnormal_survival0.63388203

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.01094507
2Focal motor seizures (HP:0011153)4.20445882
3Myokymia (HP:0002411)4.14741547
4Epileptic encephalopathy (HP:0200134)3.84501911
5Posterior subcapsular cataract (HP:0007787)3.59279267
6Colon cancer (HP:0003003)3.51607125
7Visual hallucinations (HP:0002367)3.31143709
8Febrile seizures (HP:0002373)3.22720209
9Focal seizures (HP:0007359)3.20220532
10Medulloblastoma (HP:0002885)3.16679967
11Congenital stationary night blindness (HP:0007642)3.07238209
12Hepatoblastoma (HP:0002884)3.06926348
13Cortical dysplasia (HP:0002539)2.98869491
14Ependymoma (HP:0002888)2.89988771
15Ankle clonus (HP:0011448)2.82380895
16Progressive cerebellar ataxia (HP:0002073)2.78312114
17Poor eye contact (HP:0000817)2.77338107
18Central scotoma (HP:0000603)2.71700175
19Microvesicular hepatic steatosis (HP:0001414)2.55145789
20Chromsome breakage (HP:0040012)2.54660397
21Abnormality of the aortic arch (HP:0012303)2.53701793
22Neoplasm of the adrenal cortex (HP:0100641)2.47848821
23Increased serum pyruvate (HP:0003542)2.46438443
24Abnormality of glycolysis (HP:0004366)2.46296925
25Long clavicles (HP:0000890)2.44610197
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.44318396
27Carpal bone hypoplasia (HP:0001498)2.43994871
28Abnormality of the astrocytes (HP:0100707)2.43067539
29Astrocytoma (HP:0009592)2.43067539
30Pointed chin (HP:0000307)2.42774751
31Abnormal hair whorl (HP:0010721)2.40438268
32Stereotypic behavior (HP:0000733)2.35957532
33Truncal ataxia (HP:0002078)2.34896814
34Glioma (HP:0009733)2.33379328
35Abnormal lung lobation (HP:0002101)2.33089478
36Abnormality of chromosome stability (HP:0003220)2.31762112
37Midline defect of the nose (HP:0004122)2.31709078
38Retinal dysplasia (HP:0007973)2.31065447
39Urinary urgency (HP:0000012)2.29965430
40Depression (HP:0000716)2.29562375
41Impaired social interactions (HP:0000735)2.28958473
42Abnormal social behavior (HP:0012433)2.28958473
43Broad-based gait (HP:0002136)2.28483870
44Annular pancreas (HP:0001734)2.28398419
45Severe visual impairment (HP:0001141)2.27911489
46Methylmalonic acidemia (HP:0002912)2.26074348
47Action tremor (HP:0002345)2.25417050
48Pancreatic islet-cell hyperplasia (HP:0004510)2.25180781
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25178574
50Atonic seizures (HP:0010819)2.25127156
51Trigonocephaly (HP:0000243)2.20359383
52Broad palm (HP:0001169)2.19490078
53Meckel diverticulum (HP:0002245)2.18733616
54Agnosia (HP:0010524)2.16930668
55Protruding tongue (HP:0010808)2.15131570
56Nephrogenic diabetes insipidus (HP:0009806)2.13140701
57Volvulus (HP:0002580)2.12548505
58Medial flaring of the eyebrow (HP:0010747)2.11648145
59Neoplasm of the heart (HP:0100544)2.11285013
60Congenital primary aphakia (HP:0007707)2.10995031
61Gait imbalance (HP:0002141)2.10601619
62Impaired vibration sensation in the lower limbs (HP:0002166)2.09423630
63Neoplasm of the oral cavity (HP:0100649)2.09254185
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.09092338
65Lipid accumulation in hepatocytes (HP:0006561)2.08680412
66Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08555699
67Abnormality of the ileum (HP:0001549)2.08178220
68Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08129958
69Hypoplasia of the brainstem (HP:0002365)2.08129958
70Genetic anticipation (HP:0003743)2.06732402
71Hyperglycinemia (HP:0002154)2.06392207
72Short 4th metacarpal (HP:0010044)2.05390635
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05390635
74Amyotrophic lateral sclerosis (HP:0007354)2.03718547
75Absent eyebrow (HP:0002223)2.03209172
76Exercise-induced muscle cramps (HP:0003710)2.01606482
77Flat capital femoral epiphysis (HP:0003370)2.01354016
78Irregular epiphyses (HP:0010582)2.01080042
79Spinal canal stenosis (HP:0003416)2.00162918
80Impaired smooth pursuit (HP:0007772)1.97838836
81Megalencephaly (HP:0001355)1.97635806
82Genital tract atresia (HP:0001827)1.97511014
83Abnormality of macular pigmentation (HP:0008002)1.97219200
84Increased hepatocellular lipid droplets (HP:0006565)1.96752908
85Neonatal short-limb short stature (HP:0008921)1.96723321
86Excessive salivation (HP:0003781)1.96605358
87Drooling (HP:0002307)1.96605358
88Lissencephaly (HP:0001339)1.96271250
89Vaginal atresia (HP:0000148)1.95989673
90Abnormality of methionine metabolism (HP:0010901)1.95281918
91Nephroblastoma (Wilms tumor) (HP:0002667)1.95171646
92Mutism (HP:0002300)1.95030320
93Subcapsular cataract (HP:0000523)1.95024218
94Scotoma (HP:0000575)1.94964124
95Urinary bladder sphincter dysfunction (HP:0002839)1.94310260
96Type II lissencephaly (HP:0007260)1.93901418
97Tubulointerstitial nephritis (HP:0001970)1.93747193
98Hip dysplasia (HP:0001385)1.93549081
99Renal duplication (HP:0000075)1.93348324
100Long palpebral fissure (HP:0000637)1.93322696
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93262172
102Abnormality of binocular vision (HP:0011514)1.93145475
103Diplopia (HP:0000651)1.93145475
104Hemiplegia (HP:0002301)1.93068227
105Gaze-evoked nystagmus (HP:0000640)1.91556508
106Aplasia/Hypoplasia of the uvula (HP:0010293)1.91145802
107Neoplasm of the colon (HP:0100273)1.90350999
108Abnormality of the metopic suture (HP:0005556)1.89954033
109Intellectual disability, profound (HP:0002187)1.89022717
110Multiple enchondromatosis (HP:0005701)1.89010891
111Obsessive-compulsive behavior (HP:0000722)1.88973694
112Bile duct proliferation (HP:0001408)1.88055311
113Abnormal biliary tract physiology (HP:0012439)1.88055311
114Open mouth (HP:0000194)1.87155815
115Embryonal renal neoplasm (HP:0011794)1.87111460
116Hyperventilation (HP:0002883)1.86161293
117Shoulder girdle muscle weakness (HP:0003547)1.85660011
118Limb dystonia (HP:0002451)1.81491086
119Birth length less than 3rd percentile (HP:0003561)1.81306676
120Rhabdomyosarcoma (HP:0002859)1.81033072
121Torticollis (HP:0000473)1.80130154
122Symphalangism affecting the phalanges of the hand (HP:0009773)1.79962376
123Exotropia (HP:0000577)1.79241955
124Abnormality of ocular smooth pursuit (HP:0000617)1.77781600
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77666104
126Epileptiform EEG discharges (HP:0011182)1.77022110
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.76817359
128Poor coordination (HP:0002370)1.76731934
129Macroorchidism (HP:0000053)1.76593764
130Heterochromia iridis (HP:0001100)1.76394063
131Biliary tract neoplasm (HP:0100574)1.75085308
132Short tibia (HP:0005736)1.74449863
133Progressive inability to walk (HP:0002505)1.73929117
134EEG with generalized epileptiform discharges (HP:0011198)1.73754901
135Scrotal hypoplasia (HP:0000046)1.73752137
136Methylmalonic aciduria (HP:0012120)1.73236117
137CNS hypomyelination (HP:0003429)1.73215375
138Renal cortical cysts (HP:0000803)1.72992566
139Hemiparesis (HP:0001269)1.71085605
140Dysdiadochokinesis (HP:0002075)1.71015861
141Postural instability (HP:0002172)1.70997754
142Anxiety (HP:0000739)1.70756209
143Broad foot (HP:0001769)1.70329981
144Homocystinuria (HP:0002156)1.70225683
145Abnormality of homocysteine metabolism (HP:0010919)1.70225683
146Sloping forehead (HP:0000340)1.69768680
147Dysmetric saccades (HP:0000641)1.69711305
148Generalized tonic-clonic seizures (HP:0002069)1.69463605
149Facial cleft (HP:0002006)1.69428447
150Abnormality of the corticospinal tract (HP:0002492)1.68976589
151Hyperglycinuria (HP:0003108)1.68031335
152Absence seizures (HP:0002121)1.67430550
153Hyperacusis (HP:0010780)1.67293661
154Abnormality of the pancreatic islet cells (HP:0006476)1.66428359
155Abnormality of endocrine pancreas physiology (HP:0012093)1.66428359
156Skull defect (HP:0001362)1.66261321
157High anterior hairline (HP:0009890)1.66222948
158Abnormality of serine family amino acid metabolism (HP:0010894)1.65422678
159Abnormality of glycine metabolism (HP:0010895)1.65422678
160Micropenis (HP:0000054)1.65325506
161Atrophy/Degeneration involving motor neurons (HP:0007373)1.64753344
162Neoplasm of the adrenal gland (HP:0100631)1.64715530
163Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64205508
164Degeneration of the lateral corticospinal tracts (HP:0002314)1.64205508
165Amblyopia (HP:0000646)1.63189815
166Neoplasm of the small intestine (HP:0100833)1.62687546
167Absent speech (HP:0001344)1.62522880
168Hypoglycemic coma (HP:0001325)1.62451128
169Acute lymphatic leukemia (HP:0006721)1.62219463
170Patellar aplasia (HP:0006443)1.61622414
171Hypsarrhythmia (HP:0002521)1.61593101
172Insomnia (HP:0100785)1.61536168
173Sleep apnea (HP:0010535)1.61286188
174Asymmetry of the thorax (HP:0001555)1.61085565
175Increased nuchal translucency (HP:0010880)1.60984092
176Macroglossia (HP:0000158)1.60622253
177Abnormal eating behavior (HP:0100738)1.60571217
178Rimmed vacuoles (HP:0003805)1.57982968
179Spastic gait (HP:0002064)1.57943995
180Astigmatism (HP:0000483)1.57641547
181Dandy-Walker malformation (HP:0001305)1.57469108
182Focal dystonia (HP:0004373)1.57250108
183Renovascular hypertension (HP:0100817)1.56490491
184Abnormality of the preputium (HP:0100587)1.56187671
185Elfin facies (HP:0004428)1.56144807
186Abnormality of the musculature of the pelvis (HP:0001469)1.56049428
187Abnormality of the hip-girdle musculature (HP:0001445)1.56049428
188Postaxial hand polydactyly (HP:0001162)1.55508155
189Inability to walk (HP:0002540)1.55041905
190Deeply set eye (HP:0000490)1.55006349
191Intestinal atresia (HP:0011100)1.54763420
192Supranuclear gaze palsy (HP:0000605)1.54484573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.68768120
2BRD44.60194011
3SRPK13.13683787
4MARK12.98955160
5TNIK2.94752499
6CDC72.82146452
7NTRK32.79626839
8TTK2.68409501
9MAP3K92.67433983
10BUB12.57042012
11EIF2AK32.55900424
12NEK12.52703061
13EPHB22.50772899
14EPHA42.34231800
15BCR2.26385526
16TRIM282.25568095
17MAP4K22.21335567
18MINK12.16405007
19MAP3K132.12599264
20MAP3K122.11922272
21ZAK2.11621047
22SIK31.94821043
23PLK41.94209148
24NUAK11.92792493
25MAPK131.92425899
26MAP2K71.90011874
27PRPF4B1.87987860
28PLK31.87895479
29MAP3K41.87600357
30TSSK61.86033713
31TAOK11.77179333
32RIPK11.76860365
33CASK1.75613330
34CCNB11.72547920
35CSNK1G11.70611584
36KSR11.70359796
37VRK21.69290665
38CDK191.57946561
39WNK31.48232252
40SIK21.46749282
41NTRK21.38470939
42BRSK21.33973775
43ATR1.32199866
44MAP2K41.31932362
45SGK21.30774386
46PINK11.30167969
47MKNK21.28356600
48FRK1.25137081
49SGK2231.23386417
50SGK4941.23386417
51PLK11.23136615
52MARK21.22384642
53STK161.19822073
54UHMK11.19306408
55ARAF1.19072464
56KSR21.16363709
57CDK81.15249246
58VRK11.13105258
59PBK1.13006231
60PAK61.10726108
61ERBB31.08972582
62PRKD31.07946575
63CDK51.07663513
64MKNK11.04861223
65FLT31.01648123
66ATM0.97797733
67MAP3K70.97425949
68DAPK10.95055024
69PASK0.94727108
70TAF10.94235986
71PLK20.93770208
72PHKG20.92988598
73PHKG10.92988598
74BCKDK0.91872164
75MAP3K60.90842098
76DYRK1A0.90508198
77CDK180.90392168
78CHEK20.89133450
79CAMKK10.87952804
80CHEK10.86571090
81SGK30.84997535
82CAMK10.84212174
83OBSCN0.83741805
84MAP3K100.83577889
85EIF2AK10.82860983
86CDK150.82741032
87PRKCH0.80508264
88DAPK20.79098894
89WEE10.78832554
90CDK140.77986266
91RAF10.77558060
92CDK30.76616766
93CDK11A0.76230524
94RET0.75975589
95DYRK20.74897988
96TIE10.71114525
97TAOK20.70677274
98NEK20.70347249
99EIF2AK20.69335491
100STK38L0.69018220
101AURKB0.67444397
102CSNK1E0.64974609
103CDK20.63638198
104RPS6KA40.63099633
105CAMK40.62200430
106BRSK10.61606048
107STK30.60565935
108CDK10.60273427
109ILK0.60254675
110MAP2K60.56750570
111MAPK120.56525661
112CSNK1D0.56126062
113TNK20.56124650
114PRKCG0.54612428
115INSRR0.54482993
116STK380.54313220
117AKT30.53890787
118CSNK1G20.53605230
119TEC0.53580409
120CLK10.52667356
121EEF2K0.52408624
122CDK90.51668759
123KIT0.51498309
124FES0.50648693
125BMPR1B0.50338711
126BRAF0.48695571
127FGFR10.48324414
128CAMKK20.47072460
129PRKCE0.45622941
130PRKDC0.45586000
131DMPK0.43419596
132CAMK2A0.43236198
133FGFR20.42787197
134STK110.42751833
135NEK60.41353916
136CDC42BPA0.40871659
137CDK70.40000874
138DYRK30.39997968
139SGK10.39082898
140MAPK90.38851211
141PTK2B0.38106191
142TGFBR10.37697340
143CSNK1G30.37288695
144GSK3B0.37138519
145CSNK1A1L0.36663495
146ICK0.36652728
147PRKD20.35848486
148EGFR0.35795586
149FER0.35681422
150ALK0.35018955
151MAPK100.33795266
152PNCK0.33557668
153ACVR1B0.32905700
154PRKACB0.32834474
155ROCK20.27996037
156MYLK0.27703479
157ROCK10.27604049
158EPHA30.26977922
159RPS6KA30.26535992
160MAP3K10.25778486
161CAMK1G0.25178577

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.49490749
2Non-homologous end-joining_Homo sapiens_hsa034503.35511103
3Mismatch repair_Homo sapiens_hsa034303.22668840
4Nicotine addiction_Homo sapiens_hsa050333.05899460
5DNA replication_Homo sapiens_hsa030302.85572467
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76561150
7Base excision repair_Homo sapiens_hsa034102.65685463
8Spliceosome_Homo sapiens_hsa030402.63643461
9RNA transport_Homo sapiens_hsa030132.61944379
10Olfactory transduction_Homo sapiens_hsa047402.50771815
11Circadian entrainment_Homo sapiens_hsa047132.43735511
12Synaptic vesicle cycle_Homo sapiens_hsa047212.38997897
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28578094
14GABAergic synapse_Homo sapiens_hsa047272.28193622
15Homologous recombination_Homo sapiens_hsa034402.26896067
16RNA polymerase_Homo sapiens_hsa030202.22333309
17Propanoate metabolism_Homo sapiens_hsa006402.20426995
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17841678
19Morphine addiction_Homo sapiens_hsa050322.14374730
20Fanconi anemia pathway_Homo sapiens_hsa034602.14269134
21One carbon pool by folate_Homo sapiens_hsa006702.13093887
22RNA degradation_Homo sapiens_hsa030182.12990214
23Cell cycle_Homo sapiens_hsa041102.10615692
24mRNA surveillance pathway_Homo sapiens_hsa030152.07756395
25Basal transcription factors_Homo sapiens_hsa030222.06651269
26Long-term potentiation_Homo sapiens_hsa047202.06629272
27Glutamatergic synapse_Homo sapiens_hsa047242.06299256
28Dopaminergic synapse_Homo sapiens_hsa047281.95559285
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91962474
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91606185
31Cholinergic synapse_Homo sapiens_hsa047251.88160999
32Amphetamine addiction_Homo sapiens_hsa050311.82776774
33Steroid biosynthesis_Homo sapiens_hsa001001.79156120
34Selenocompound metabolism_Homo sapiens_hsa004501.79014393
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78526860
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73375972
37Insulin secretion_Homo sapiens_hsa049111.72619683
38Nucleotide excision repair_Homo sapiens_hsa034201.71989439
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70192298
40Salivary secretion_Homo sapiens_hsa049701.69336282
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62640708
42Oxytocin signaling pathway_Homo sapiens_hsa049211.62150255
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60393590
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55507264
45Long-term depression_Homo sapiens_hsa047301.51824039
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50352745
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48915200
48Butanoate metabolism_Homo sapiens_hsa006501.48409947
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.48386067
50Serotonergic synapse_Homo sapiens_hsa047261.47475745
51Biosynthesis of amino acids_Homo sapiens_hsa012301.42091283
52Renin secretion_Homo sapiens_hsa049241.40487112
53Axon guidance_Homo sapiens_hsa043601.40411543
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39800731
55Cocaine addiction_Homo sapiens_hsa050301.39427727
56GnRH signaling pathway_Homo sapiens_hsa049121.35186377
57Calcium signaling pathway_Homo sapiens_hsa040201.34414042
58Gastric acid secretion_Homo sapiens_hsa049711.34388757
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33954527
60Protein export_Homo sapiens_hsa030601.33502981
61Phototransduction_Homo sapiens_hsa047441.33448326
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33113479
63Gap junction_Homo sapiens_hsa045401.30457101
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28256566
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26989866
66Proteasome_Homo sapiens_hsa030501.26743701
67Endometrial cancer_Homo sapiens_hsa052131.23075705
68Carbon metabolism_Homo sapiens_hsa012001.21577820
69Purine metabolism_Homo sapiens_hsa002301.19267614
70Glioma_Homo sapiens_hsa052141.16500398
71Oocyte meiosis_Homo sapiens_hsa041141.16177143
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15301448
73ErbB signaling pathway_Homo sapiens_hsa040121.14675649
74Pyrimidine metabolism_Homo sapiens_hsa002401.13421232
75Lysine degradation_Homo sapiens_hsa003101.12523490
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12084712
77Fatty acid elongation_Homo sapiens_hsa000621.10626197
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10144222
79cAMP signaling pathway_Homo sapiens_hsa040241.09503076
80Pyruvate metabolism_Homo sapiens_hsa006201.08726129
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07817663
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05861631
83Colorectal cancer_Homo sapiens_hsa052101.05330159
84Melanogenesis_Homo sapiens_hsa049161.05279060
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04556836
86Taste transduction_Homo sapiens_hsa047421.03239757
87Neurotrophin signaling pathway_Homo sapiens_hsa047221.02736799
88Fatty acid metabolism_Homo sapiens_hsa012121.01635347
89Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01168660
90Dilated cardiomyopathy_Homo sapiens_hsa054141.01112109
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99256616
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99122677
93Estrogen signaling pathway_Homo sapiens_hsa049150.93334747
94Type II diabetes mellitus_Homo sapiens_hsa049300.92766041
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92529972
96Regulation of autophagy_Homo sapiens_hsa041400.92426238
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92160299
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90862320
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89618982
100Non-small cell lung cancer_Homo sapiens_hsa052230.89173953
101MAPK signaling pathway_Homo sapiens_hsa040100.87637227
102Circadian rhythm_Homo sapiens_hsa047100.86641659
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86359286
104Wnt signaling pathway_Homo sapiens_hsa043100.85663189
105Cardiac muscle contraction_Homo sapiens_hsa042600.85334308
106Parkinsons disease_Homo sapiens_hsa050120.84232851
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83004854
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80427913
109Chronic myeloid leukemia_Homo sapiens_hsa052200.79379106
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78454726
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.78451984
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.77199851
113Rap1 signaling pathway_Homo sapiens_hsa040150.76952443
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76925251
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73571234
116p53 signaling pathway_Homo sapiens_hsa041150.73032067
117Hedgehog signaling pathway_Homo sapiens_hsa043400.72433832
118Choline metabolism in cancer_Homo sapiens_hsa052310.72165772
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69676268
120VEGF signaling pathway_Homo sapiens_hsa043700.69425213
121mTOR signaling pathway_Homo sapiens_hsa041500.69333941
122Caffeine metabolism_Homo sapiens_hsa002320.68579456
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66760086
124Vitamin B6 metabolism_Homo sapiens_hsa007500.65850714
125Glucagon signaling pathway_Homo sapiens_hsa049220.65799624
126T cell receptor signaling pathway_Homo sapiens_hsa046600.65626732
127Ras signaling pathway_Homo sapiens_hsa040140.64041376
128Insulin signaling pathway_Homo sapiens_hsa049100.63205953
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.61946678
130Endocytosis_Homo sapiens_hsa041440.61540759
131Dorso-ventral axis formation_Homo sapiens_hsa043200.61175930
132Platelet activation_Homo sapiens_hsa046110.61101609
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.60413442
134Huntingtons disease_Homo sapiens_hsa050160.60379789
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59933426
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59856968
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59286248
138Pancreatic cancer_Homo sapiens_hsa052120.58190504
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56751590
140Peroxisome_Homo sapiens_hsa041460.56700581
141Hippo signaling pathway_Homo sapiens_hsa043900.56357669
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55849254
143Renal cell carcinoma_Homo sapiens_hsa052110.55061862
144Basal cell carcinoma_Homo sapiens_hsa052170.54630829
145Chemokine signaling pathway_Homo sapiens_hsa040620.52042934
146Oxidative phosphorylation_Homo sapiens_hsa001900.51940111
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50871169
148Metabolic pathways_Homo sapiens_hsa011000.49849114
149Alcoholism_Homo sapiens_hsa050340.48897489
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47756818
151Notch signaling pathway_Homo sapiens_hsa043300.47746778
152Shigellosis_Homo sapiens_hsa051310.44257262
153TGF-beta signaling pathway_Homo sapiens_hsa043500.43972992
154Ovarian steroidogenesis_Homo sapiens_hsa049130.43890954
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43770344
156Thyroid cancer_Homo sapiens_hsa052160.43220190
157Thyroid hormone synthesis_Homo sapiens_hsa049180.42168147
158Fatty acid degradation_Homo sapiens_hsa000710.40765768
159Arginine and proline metabolism_Homo sapiens_hsa003300.40299240
160Adherens junction_Homo sapiens_hsa045200.38376843
161Inositol phosphate metabolism_Homo sapiens_hsa005620.28879686
162Pentose phosphate pathway_Homo sapiens_hsa000300.28456227
163Alzheimers disease_Homo sapiens_hsa050100.28222738
164Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25394500
165Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23862634
166Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23563133
167N-Glycan biosynthesis_Homo sapiens_hsa005100.20972981
168Tight junction_Homo sapiens_hsa045300.20790098
169Sulfur metabolism_Homo sapiens_hsa009200.17765509
170MicroRNAs in cancer_Homo sapiens_hsa052060.16171285
171beta-Alanine metabolism_Homo sapiens_hsa004100.15781347
172Primary bile acid biosynthesis_Homo sapiens_hsa001200.14858544
173Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13703677

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