HMG20B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)6.69673595
2melanin metabolic process (GO:0006582)6.08507651
3COPI coating of Golgi vesicle (GO:0048205)5.20282139
4Golgi transport vesicle coating (GO:0048200)5.20282139
5secondary metabolite biosynthetic process (GO:0044550)5.12429212
6DNA deamination (GO:0045006)4.54553232
7viral transcription (GO:0019083)4.35517374
8ribosomal small subunit assembly (GO:0000028)4.28872273
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.25177751
10translational termination (GO:0006415)4.12651556
11amyloid precursor protein catabolic process (GO:0042987)3.88628939
12barbed-end actin filament capping (GO:0051016)3.88581024
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.77435643
14translational elongation (GO:0006414)3.73697314
15protein retention in ER lumen (GO:0006621)3.73325752
16pinocytosis (GO:0006907)3.61892020
17GDP-mannose metabolic process (GO:0019673)3.61104786
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50341324
19mannose metabolic process (GO:0006013)3.48561217
20ribosomal small subunit biogenesis (GO:0042274)3.48172349
21protein maturation by protein folding (GO:0022417)3.43679823
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40865268
23UV protection (GO:0009650)3.38742253
24protein targeting to ER (GO:0045047)3.36162045
25viral life cycle (GO:0019058)3.29681662
26mitotic nuclear envelope reassembly (GO:0007084)3.27577756
27nuclear envelope reassembly (GO:0031468)3.27577756
28translational initiation (GO:0006413)3.24372704
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24286635
30cotranslational protein targeting to membrane (GO:0006613)3.23382123
31peptidyl-arginine omega-N-methylation (GO:0035247)3.18108727
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16605207
33melanocyte differentiation (GO:0030318)3.15886961
34positive regulation of Cdc42 GTPase activity (GO:0043089)3.14251719
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11161562
36response to thyroid hormone (GO:0097066)3.09738412
37protein localization to endoplasmic reticulum (GO:0070972)3.09182085
38pigment cell differentiation (GO:0050931)3.06965000
39pentose metabolic process (GO:0019321)3.04979043
40epithelial cell-cell adhesion (GO:0090136)3.02141765
41cellular protein complex disassembly (GO:0043624)3.00554441
42epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94934980
43protein localization to endosome (GO:0036010)2.93821042
44glycosphingolipid catabolic process (GO:0046479)2.92743482
45cellular response to thyroid hormone stimulus (GO:0097067)2.91998663
46regulation of early endosome to late endosome transport (GO:2000641)2.90315775
47pentose-phosphate shunt (GO:0006098)2.87502156
48ribosomal large subunit biogenesis (GO:0042273)2.84454519
49positive regulation of odontogenesis (GO:0042482)2.83241336
50maternal placenta development (GO:0001893)2.82838277
51tyrosine metabolic process (GO:0006570)2.81386354
52glucose 6-phosphate metabolic process (GO:0051156)2.80668411
53protein complex disassembly (GO:0043241)2.76150814
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75875766
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75875766
56positive regulation of keratinocyte differentiation (GO:0045618)2.75135879
57formation of translation preinitiation complex (GO:0001731)2.74889578
58maturation of SSU-rRNA (GO:0030490)2.74850913
59negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.73833790
60heterochromatin organization (GO:0070828)2.70934998
61ncRNA 3-end processing (GO:0043628)2.70471782
62semaphorin-plexin signaling pathway (GO:0071526)2.68599664
63glycolipid catabolic process (GO:0019377)2.56983794
64intracellular estrogen receptor signaling pathway (GO:0030520)2.55200218
65endothelial cell chemotaxis (GO:0035767)2.54197505
66macromolecular complex disassembly (GO:0032984)2.53490178
67T cell apoptotic process (GO:0070231)2.52407474
68apoptotic process involved in morphogenesis (GO:0060561)2.52181784
69endosome to melanosome transport (GO:0035646)2.49559026
70endosome to pigment granule transport (GO:0043485)2.49559026
71urea cycle (GO:0000050)2.49216510
72amino sugar catabolic process (GO:0046348)2.48654377
73adherens junction assembly (GO:0034333)2.48208458
74positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.48177748
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47961978
76folic acid-containing compound biosynthetic process (GO:0009396)2.46227186
77modulation by virus of host process (GO:0019054)2.46036736
78antigen processing and presentation of endogenous antigen (GO:0019883)2.45520412
79mitotic chromosome condensation (GO:0007076)2.45312721
80amyloid precursor protein metabolic process (GO:0042982)2.43662603
81modulation by symbiont of host cellular process (GO:0044068)2.41632321
82NADPH regeneration (GO:0006740)2.40790671
83adhesion of symbiont to host (GO:0044406)2.40618701
84snRNA metabolic process (GO:0016073)2.40435355
85positive regulation of nuclease activity (GO:0032075)2.40418146
86hyaluronan catabolic process (GO:0030214)2.39498969
87membrane protein ectodomain proteolysis (GO:0006509)2.38974316
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38627887
89DNA strand elongation involved in DNA replication (GO:0006271)2.37420855
90proline biosynthetic process (GO:0006561)2.37223932
91bundle of His cell to Purkinje myocyte communication (GO:0086069)2.36457334
92establishment of apical/basal cell polarity (GO:0035089)2.36208852
93histone arginine methylation (GO:0034969)2.33949942
94regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.33485543
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32936769
96membrane protein intracellular domain proteolysis (GO:0031293)2.32203057
97peptidyl-arginine methylation (GO:0018216)2.31827114
98peptidyl-arginine N-methylation (GO:0035246)2.31827114
99DNA unwinding involved in DNA replication (GO:0006268)2.31569446
100positive regulation of DNA-dependent DNA replication (GO:2000105)2.30694698
101NIK/NF-kappaB signaling (GO:0038061)2.30690018
102spliceosomal tri-snRNP complex assembly (GO:0000244)2.30627341
103telomere maintenance via semi-conservative replication (GO:0032201)2.29572807
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.28907329
105basement membrane organization (GO:0071711)2.28515887
106regulation of superoxide anion generation (GO:0032928)2.27280846
107negative regulation of macroautophagy (GO:0016242)2.26863720
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.26226837
109regulation of cholesterol storage (GO:0010885)2.25992419
110pteridine-containing compound biosynthetic process (GO:0042559)2.25839360
111nucleoside salvage (GO:0043174)2.25799945
112pigment biosynthetic process (GO:0046148)2.24680173
113protein targeting to membrane (GO:0006612)2.24417774
114activation of Rac GTPase activity (GO:0032863)2.23924079
115negative regulation of viral release from host cell (GO:1902187)2.23914120
116mitotic G1 DNA damage checkpoint (GO:0031571)2.23575250
117DNA strand elongation (GO:0022616)2.23508436
118endothelial tube morphogenesis (GO:0061154)2.23054941
119morphogenesis of an endothelium (GO:0003159)2.23054941
120cell-substrate adherens junction assembly (GO:0007045)2.22603582
121focal adhesion assembly (GO:0048041)2.22603582
122sulfur amino acid catabolic process (GO:0000098)2.22303784
123folic acid metabolic process (GO:0046655)2.20901146
124regulation of hippo signaling (GO:0035330)2.20154407
125ribonucleoprotein complex biogenesis (GO:0022613)2.19954033
126endoplasmic reticulum unfolded protein response (GO:0030968)2.19433921
127regulation of apoptotic process involved in morphogenesis (GO:1902337)2.18924480
128endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.18299144
129lymphocyte apoptotic process (GO:0070227)2.17233625
130mRNA catabolic process (GO:0006402)2.16660578
131translation (GO:0006412)2.16469779
132mammary gland epithelial cell differentiation (GO:0060644)2.16116025
133virion assembly (GO:0019068)2.15896763
134cytidine metabolic process (GO:0046087)2.15353028
135cytidine catabolic process (GO:0006216)2.15353028
136cytidine deamination (GO:0009972)2.15353028
1374-hydroxyproline metabolic process (GO:0019471)2.15238070
138pyrimidine nucleoside salvage (GO:0043097)2.13260027
139pyrimidine-containing compound salvage (GO:0008655)2.13260027
140RNA catabolic process (GO:0006401)2.13037712
141negative regulation of erythrocyte differentiation (GO:0045647)2.12961689
142glucose catabolic process (GO:0006007)2.12389847
143positive regulation of SMAD protein import into nucleus (GO:0060391)2.11892729
144oxidative phosphorylation (GO:0006119)2.11113042
145heme biosynthetic process (GO:0006783)2.09886385
146regulation of SMAD protein import into nucleus (GO:0060390)2.05609373
147regulation of posttranscriptional gene silencing (GO:0060147)2.05215791
148regulation of gene silencing by miRNA (GO:0060964)2.05215791
149regulation of gene silencing by RNA (GO:0060966)2.05215791
150gap junction assembly (GO:0016264)2.04641199
151antigen processing and presentation via MHC class Ib (GO:0002475)2.03822429
152mitochondrial DNA metabolic process (GO:0032042)2.03210765
153regulation of translational fidelity (GO:0006450)2.02882769
154regulation of integrin activation (GO:0033623)2.01703839
155negative regulation of innate immune response (GO:0045824)2.01687573
156trophectodermal cell differentiation (GO:0001829)2.01046324
157glycine metabolic process (GO:0006544)2.00969190
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.00920172
159polarized epithelial cell differentiation (GO:0030859)2.00891669
160negative regulation of cell size (GO:0045792)1.99237271
161response to laminar fluid shear stress (GO:0034616)1.98198463
162nucleotide salvage (GO:0043173)1.97933534
163sarcomere organization (GO:0045214)1.97685488
164atrioventricular valve morphogenesis (GO:0003181)1.97252976
165endodermal cell differentiation (GO:0035987)1.96964584
1663-UTR-mediated mRNA stabilization (GO:0070935)1.96284885
167regulation of gamma-delta T cell differentiation (GO:0045586)1.95620351
168mitotic G1/S transition checkpoint (GO:0044819)1.94627024
169negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.94264670
170cellular hyperosmotic response (GO:0071474)1.93656168
171regulation of type I interferon-mediated signaling pathway (GO:0060338)1.93226012
172hemidesmosome assembly (GO:0031581)1.93037300
173regulation of cholesterol homeostasis (GO:2000188)1.91602144
174paraxial mesoderm development (GO:0048339)1.91462584
175regulation of protein heterodimerization activity (GO:0043497)1.90359555
176proline metabolic process (GO:0006560)1.90162242
177telomere maintenance via recombination (GO:0000722)1.90012291
178activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO1.88973096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.56496011
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.55174114
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11335314
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50862285
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.41088459
6VDR_21846776_ChIP-Seq_THP-1_Human2.20607911
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.13184997
8MYC_22102868_ChIP-Seq_BL_Human2.09603235
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96073720
10ELK3_25401928_ChIP-Seq_HUVEC_Human1.88660617
11RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87663600
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86187542
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83341834
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77916947
15MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75451649
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71124709
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67137728
18STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64920163
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64356507
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64248982
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63893463
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63114056
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.62754850
24ZNF263_19887448_ChIP-Seq_K562_Human1.60441768
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54658562
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50492036
27LXR_22292898_ChIP-Seq_THP-1_Human1.47714545
28XRN2_22483619_ChIP-Seq_HELA_Human1.46165742
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45572040
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44149917
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.43717071
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43331215
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41758409
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.40873025
35RACK7_27058665_Chip-Seq_MCF-7_Human1.40689733
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38835127
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37093487
38ATF3_27146783_Chip-Seq_COLON_Human1.36487367
39* ELF1_20517297_ChIP-Seq_JURKAT_Human1.36485869
40TCF7_22412390_ChIP-Seq_EML_Mouse1.35348282
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.34511484
42MAF_26560356_Chip-Seq_TH1_Human1.33071094
43* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33024534
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32802895
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32223866
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30818961
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30098546
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28528695
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28460590
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26841021
51SMC4_20622854_ChIP-Seq_HELA_Human1.26432706
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26080942
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25560794
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24670471
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24445562
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22993996
57CLOCK_20551151_ChIP-Seq_293T_Human1.22720191
58UTX_26944678_Chip-Seq_JUKART_Human1.22565576
59CIITA_25753668_ChIP-Seq_RAJI_Human1.21780445
60KDM2B_26808549_Chip-Seq_K562_Human1.21142741
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20761645
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20568398
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20314946
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18315195
65* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18030441
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17975990
67* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16946416
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16727711
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16588649
70VDR_24763502_ChIP-Seq_THP-1_Human1.16395197
71KDM2B_26808549_Chip-Seq_DND41_Human1.16381959
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16244639
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14729602
74CREB1_26743006_Chip-Seq_LNCaP_Human1.14679318
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.14525417
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14260075
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14027788
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13633876
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13545017
80* CTCF_26484167_Chip-Seq_Bcells_Mouse1.12789813
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11921066
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11680668
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11651690
84* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10638668
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09891093
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09789433
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08796607
88* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08499593
89DCP1A_22483619_ChIP-Seq_HELA_Human1.07630595
90MAF_26560356_Chip-Seq_TH2_Human1.07547650
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07474177
92* NCOR1_26117541_ChIP-Seq_K562_Human1.07222854
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07104885
94* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06949075
95* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06811227
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06426397
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.06138964
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05938638
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05757266
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05345741
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04953612
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04779836
103AR_21909140_ChIP-Seq_LNCAP_Human1.04657885
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04513142
105* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04035027
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.03568661
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03208590
108* P68_20966046_ChIP-Seq_HELA_Human1.02549794
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02315541
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.01831649
111BCL6_27268052_Chip-Seq_Bcells_Human1.00098117
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99563395
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99097938
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98825465
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98234303
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97846709
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97565635
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.97411173
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96358856
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96329609
121BCOR_27268052_Chip-Seq_Bcells_Human0.96171557
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96031323
123GABP_19822575_ChIP-Seq_HepG2_Human0.95924790
124* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95410800
125CTCF_21964334_Chip-Seq_Bcells_Human0.95306716
126TFEB_21752829_ChIP-Seq_HELA_Human0.94338218
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.94273702
128* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94269087
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93358946
130SCL_19346495_ChIP-Seq_HPC-7_Human0.92991894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.48935963
2MP0003136_yellow_coat_color3.69756246
3MP0000015_abnormal_ear_pigmentation3.20868060
4MP0004381_abnormal_hair_follicle3.06485578
5MP0003705_abnormal_hypodermis_morpholog3.00212809
6MP0000372_irregular_coat_pigmentation2.95029460
7MP0005075_abnormal_melanosome_morpholog2.67960578
8MP0005257_abnormal_intraocular_pressure2.58530532
9MP0005408_hypopigmentation2.38326719
10MP0005409_darkened_coat_color2.36798143
11MP0003172_abnormal_lysosome_physiology2.20999726
12MP0008260_abnormal_autophagy2.17284679
13MP0000371_diluted_coat_color2.11581097
14MP0003566_abnormal_cell_adhesion2.02034836
15MP0009840_abnormal_foam_cell1.94331889
16MP0010352_gastrointestinal_tract_polyps1.90591601
17MP0005174_abnormal_tail_pigmentation1.90373773
18MP0010030_abnormal_orbit_morphology1.88957463
19MP0004858_abnormal_nervous_system1.85495424
20MP0008438_abnormal_cutaneous_collagen1.73740724
21MP0002075_abnormal_coat/hair_pigmentati1.69229082
22MP0009278_abnormal_bone_marrow1.63266003
23MP0000678_abnormal_parathyroid_gland1.62559012
24MP0003693_abnormal_embryo_hatching1.54153298
25MP0000490_abnormal_crypts_of1.53779311
26MP0002095_abnormal_skin_pigmentation1.49420156
27MP0003806_abnormal_nucleotide_metabolis1.45114912
28MP0005360_urolithiasis1.44829069
29MP0005464_abnormal_platelet_physiology1.44473180
30MP0005023_abnormal_wound_healing1.42868723
31MP0005275_abnormal_skin_tensile1.41028400
32MP0004957_abnormal_blastocyst_morpholog1.39769661
33MP0003191_abnormal_cellular_cholesterol1.39342727
34MP0001186_pigmentation_phenotype1.37716627
35MP0003283_abnormal_digestive_organ1.33294611
36MP0002396_abnormal_hematopoietic_system1.31903395
37MP0000685_abnormal_immune_system1.31303000
38MP0004084_abnormal_cardiac_muscle1.30737290
39MP0003279_aneurysm1.30610646
40MP0003300_gastrointestinal_ulcer1.25329563
41MP0005076_abnormal_cell_differentiation1.24760515
42MP0002060_abnormal_skin_morphology1.24726208
43MP0003567_abnormal_fetal_cardiomyocyte1.24264427
44MP0006054_spinal_hemorrhage1.24023204
45MP0010155_abnormal_intestine_physiology1.24000864
46MP0003453_abnormal_keratinocyte_physiol1.22791337
47MP0009333_abnormal_splenocyte_physiolog1.22558266
48MP0003111_abnormal_nucleus_morphology1.21265972
49MP0001545_abnormal_hematopoietic_system1.21119250
50MP0005397_hematopoietic_system_phenotyp1.21119250
51MP0002089_abnormal_postnatal_growth/wei1.20167523
52MP0001849_ear_inflammation1.19529336
53MP0010234_abnormal_vibrissa_follicle1.19272676
54MP0004233_abnormal_muscle_weight1.18838168
55MP0003077_abnormal_cell_cycle1.14055868
56MP0005377_hearing/vestibular/ear_phenot1.13115012
57MP0003878_abnormal_ear_physiology1.13115012
58MP0009053_abnormal_anal_canal1.12853952
59MP0004272_abnormal_basement_membrane1.12262635
60MP0005670_abnormal_white_adipose1.09827163
61MP0010630_abnormal_cardiac_muscle1.09488751
62MP0010368_abnormal_lymphatic_system1.08149485
63MP0003303_peritoneal_inflammation1.07361707
64MP0002138_abnormal_hepatobiliary_system1.07272644
65MP0005501_abnormal_skin_physiology1.07210463
66MP0000003_abnormal_adipose_tissue1.07155126
67MP0002796_impaired_skin_barrier1.07048727
68MP0005058_abnormal_lysosome_morphology1.06648120
69MP0003828_pulmonary_edema1.05571974
70MP0000477_abnormal_intestine_morphology1.05268332
71MP0002249_abnormal_larynx_morphology1.05151694
72MP0000750_abnormal_muscle_regeneration1.04849274
73MP0000733_abnormal_muscle_development1.03048006
74MP0002877_abnormal_melanocyte_morpholog1.02272297
75MP0008007_abnormal_cellular_replicative1.00986729
76MP0005330_cardiomyopathy1.00055792
77MP0000767_abnormal_smooth_muscle0.99718298
78MP0003436_decreased_susceptibility_to0.99201077
79MP0004808_abnormal_hematopoietic_stem0.97348351
80MP0005375_adipose_tissue_phenotype0.96608791
81MP0004947_skin_inflammation0.96586750
82MP0001873_stomach_inflammation0.96445720
83MP0004185_abnormal_adipocyte_glucose0.93011636
84MP0009643_abnormal_urine_homeostasis0.92077134
85MP0002166_altered_tumor_susceptibility0.91867169
86MP0003252_abnormal_bile_duct0.91693345
87MP0002254_reproductive_system_inflammat0.91537492
88MP0002234_abnormal_pharynx_morphology0.90407761
89MP0008932_abnormal_embryonic_tissue0.90369664
90MP0001730_embryonic_growth_arrest0.90223411
91MP0000350_abnormal_cell_proliferation0.89434138
92MP0005083_abnormal_biliary_tract0.88892673
93MP0005666_abnormal_adipose_tissue0.86517125
94MP0002086_abnormal_extraembryonic_tissu0.86004223
95MP0003984_embryonic_growth_retardation0.85573077
96MP0002088_abnormal_embryonic_growth/wei0.84796927
97MP0000467_abnormal_esophagus_morphology0.84325436
98MP0001243_abnormal_dermal_layer0.83958426
99MP0000858_altered_metastatic_potential0.83164454
100MP0000681_abnormal_thyroid_gland0.82564549
101MP0005380_embryogenesis_phenotype0.82487428
102MP0001672_abnormal_embryogenesis/_devel0.82487428
103MP0003186_abnormal_redox_activity0.82476116
104MP0002019_abnormal_tumor_incidence0.82266342
105MP0000598_abnormal_liver_morphology0.81509860
106MP0004264_abnormal_extraembryonic_tissu0.80619122
107MP0003941_abnormal_skin_development0.79587078
108MP0010094_abnormal_chromosome_stability0.79185750
109MP0002139_abnormal_hepatobiliary_system0.78698178
110MP0005319_abnormal_enzyme/_coenzyme0.76676569
111MP0000343_altered_response_to0.76447939
112MP0004087_abnormal_muscle_fiber0.76236999
113MP0001853_heart_inflammation0.76218341
114MP0002148_abnormal_hypersensitivity_rea0.75433585
115MP0005451_abnormal_body_composition0.75294530
116MP0002080_prenatal_lethality0.75172280
117MP0002998_abnormal_bone_remodeling0.75070283
118MP0001958_emphysema0.75024700
119MP0002098_abnormal_vibrissa_morphology0.74733263
120MP0001697_abnormal_embryo_size0.74565422
121MP0000609_abnormal_liver_physiology0.74480880
122MP0003763_abnormal_thymus_physiology0.74238034
123MP0001544_abnormal_cardiovascular_syste0.73627779
124MP0005385_cardiovascular_system_phenoty0.73627779
125MP0002722_abnormal_immune_system0.73530694
126MP0009931_abnormal_skin_appearance0.73443007
127MP0000377_abnormal_hair_follicle0.73146942
128MP0002419_abnormal_innate_immunity0.72113405
129MP0001216_abnormal_epidermal_layer0.71595586
130MP0001835_abnormal_antigen_presentation0.71561907
131MP0000358_abnormal_cell_content/0.71542313
132MP0004197_abnormal_fetal_growth/weight/0.70820576
133MP0001348_abnormal_lacrimal_gland0.70707010
134MP0005025_abnormal_response_to0.70680066
135MP0006138_congestive_heart_failure0.70569649
136MP0002398_abnormal_bone_marrow0.69799263
137MP0001881_abnormal_mammary_gland0.68285588
138MP0000367_abnormal_coat/_hair0.66917562
139MP0000465_gastrointestinal_hemorrhage0.66105212
140MP0005621_abnormal_cell_physiology0.64523194
141MP0003091_abnormal_cell_migration0.63394797
142MP0001188_hyperpigmentation0.62105607
143MP0005623_abnormal_meninges_morphology0.60857269
144MP0000537_abnormal_urethra_morphology0.60819519
145MP0001533_abnormal_skeleton_physiology0.59028292
146MP0000313_abnormal_cell_death0.57582048
147MP0001324_abnormal_eye_pigmentation0.55728354
148MP0004510_myositis0.55416155
149MP0009384_cardiac_valve_regurgitation0.55403208
150MP0003183_abnormal_peptide_metabolism0.55230853

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)4.29435227
2Abnormality of liposaccharide metabolism (HP:0010968)3.96227910
3Abnormality of glycosphingolipid metabolism (HP:0004343)3.96227910
4Abnormality of glycolipid metabolism (HP:0010969)3.96227910
5Protrusio acetabuli (HP:0003179)3.64049063
6Patchy hypopigmentation of hair (HP:0011365)3.62972874
7Pustule (HP:0200039)3.50861166
8Ocular albinism (HP:0001107)3.50748035
9J-shaped sella turcica (HP:0002680)3.50062250
10Increased cerebral lipofuscin (HP:0011813)3.24528323
11Dysostosis multiplex (HP:0000943)3.06468200
12Reticulocytopenia (HP:0001896)3.02137072
13Increased neuronal autofluorescent lipopigment (HP:0002074)2.94875868
14Abnormality of cells of the erythroid lineage (HP:0012130)2.89070449
15Aplasia/Hypoplasia of the macula (HP:0008059)2.87411864
16Right ventricular cardiomyopathy (HP:0011663)2.81902319
17Ankle contracture (HP:0006466)2.81483723
18Premature rupture of membranes (HP:0001788)2.75500428
19Ventricular tachycardia (HP:0004756)2.74393874
20Abnormal number of erythroid precursors (HP:0012131)2.72321644
21Achilles tendon contracture (HP:0001771)2.68516589
22Aplasia/Hypoplasia affecting the retina (HP:0008061)2.66523787
23Cholecystitis (HP:0001082)2.65964306
24Abnormal gallbladder physiology (HP:0012438)2.65964306
25Iris hypopigmentation (HP:0007730)2.65073559
26Broad face (HP:0000283)2.52298233
27Distal lower limb amyotrophy (HP:0008944)2.48464475
28Loss of speech (HP:0002371)2.46398734
29Heterochromia iridis (HP:0001100)2.44748098
30Increased connective tissue (HP:0009025)2.44215992
31Cerebral aneurysm (HP:0004944)2.42955490
32Trismus (HP:0000211)2.41586788
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.40744017
34Hypoplasia of the fovea (HP:0007750)2.40744017
35Hypopigmentation of the fundus (HP:0007894)2.39742016
36Multiple enchondromatosis (HP:0005701)2.38355721
37Abnormality of the Achilles tendon (HP:0005109)2.35392035
38Nuclear cataract (HP:0100018)2.34941487
39Flat acetabular roof (HP:0003180)2.34720308
40Fragile skin (HP:0001030)2.34154535
41Stridor (HP:0010307)2.33586085
42Alopecia of scalp (HP:0002293)2.30405470
43Polycythemia (HP:0001901)2.28565862
44Upper limb amyotrophy (HP:0009129)2.27724944
45Distal upper limb amyotrophy (HP:0007149)2.27724944
46Cervical subluxation (HP:0003308)2.26759790
47Purpura (HP:0000979)2.25079326
48Elbow flexion contracture (HP:0002987)2.24353325
49Hypertensive crisis (HP:0100735)2.22367734
50Abnormality of polysaccharide metabolism (HP:0011012)2.21651265
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21651265
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21651265
53Mesangial abnormality (HP:0001966)2.19499339
54Bulbar palsy (HP:0001283)2.18745238
55Mucopolysacchariduria (HP:0008155)2.17755021
56Urinary glycosaminoglycan excretion (HP:0003541)2.17755021
57Selective tooth agenesis (HP:0001592)2.17527425
58Peritonitis (HP:0002586)2.13434214
59Hepatosplenomegaly (HP:0001433)2.11859778
60Abnormal cartilage morphology (HP:0002763)2.11841389
61Biconcave vertebral bodies (HP:0004586)2.11266838
62Broad metatarsal (HP:0001783)2.07756223
63Atrophic scars (HP:0001075)2.07366964
64Abnormality of the thoracic spine (HP:0100711)2.06912465
65Microretrognathia (HP:0000308)2.06368998
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05014143
67Deformed sella turcica (HP:0002681)2.02770109
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.02495110
69Neoplasm of head and neck (HP:0012288)2.02404769
70Esophageal neoplasm (HP:0100751)2.02404769
71Macrocytic anemia (HP:0001972)2.02284842
72Vacuolated lymphocytes (HP:0001922)2.02173652
73Long palpebral fissure (HP:0000637)1.98401933
74Pallor (HP:0000980)1.96893156
75Natal tooth (HP:0000695)1.94715860
76Long toe (HP:0010511)1.93255477
77Prolonged neonatal jaundice (HP:0006579)1.92140761
78Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92010293
79Dicarboxylic aciduria (HP:0003215)1.92010293
80Blue sclerae (HP:0000592)1.91882326
81Hypoglycemic coma (HP:0001325)1.91491067
82Thrombocytosis (HP:0001894)1.91299172
83Hemorrhage of the eye (HP:0011885)1.89863100
84Nausea (HP:0002018)1.89831048
85Generalized amyotrophy (HP:0003700)1.89684569
86Premature graying of hair (HP:0002216)1.89639498
87Sparse lateral eyebrow (HP:0005338)1.89383876
88Reticulocytosis (HP:0001923)1.89284728
89Ulnar bowing (HP:0003031)1.88706744
90Abnormality of reticulocytes (HP:0004312)1.88688904
91Short nail (HP:0001799)1.88044567
92Blue irides (HP:0000635)1.87882152
93Thoracic kyphosis (HP:0002942)1.85990602
94Breech presentation (HP:0001623)1.85801662
95Hyperparathyroidism (HP:0000843)1.85681973
96Rectal prolapse (HP:0002035)1.85640806
97Increased serum ferritin (HP:0003281)1.85568832
98Insomnia (HP:0100785)1.85472277
99Petechiae (HP:0000967)1.85334830
100Cutaneous melanoma (HP:0012056)1.84856842
101Hypoplasia of the iris (HP:0007676)1.84002497
102Abnormal hemoglobin (HP:0011902)1.83859084
103Abnormality of the acetabulum (HP:0003170)1.81876887
104Abnormality of the umbilical cord (HP:0010881)1.81326016
105Spastic paraparesis (HP:0002313)1.81212263
106Axonal loss (HP:0003447)1.80756590
107Broad distal phalanx of finger (HP:0009836)1.80657148
108Nonimmune hydrops fetalis (HP:0001790)1.80377694
109Lipoatrophy (HP:0100578)1.79286021
110Hand muscle atrophy (HP:0009130)1.79092880
111Vertebral compression fractures (HP:0002953)1.78751455
112Testicular atrophy (HP:0000029)1.78655521
113Atelectasis (HP:0100750)1.78610414
114Abnormality of the distal phalanges of the toes (HP:0010182)1.77696633
115Genu recurvatum (HP:0002816)1.76133949
116Asymmetric septal hypertrophy (HP:0001670)1.75899138
117Esophageal varix (HP:0002040)1.75293067
118Patellar dislocation (HP:0002999)1.73635046
119Neonatal short-limb short stature (HP:0008921)1.72294603
120Cellulitis (HP:0100658)1.70789013
121Shallow orbits (HP:0000586)1.69884138
122Gastrointestinal inflammation (HP:0004386)1.69524357
123Abdominal distention (HP:0003270)1.68803602
124Sudden death (HP:0001699)1.68303810
125Hyperglycinuria (HP:0003108)1.67636551
126Ileus (HP:0002595)1.67539856
127Paraparesis (HP:0002385)1.67507744
128Interstitial pulmonary disease (HP:0006530)1.66875170
129Mildly elevated creatine phosphokinase (HP:0008180)1.66576201
130Abnormality of the fovea (HP:0000493)1.66133557
131Hypertriglyceridemia (HP:0002155)1.65385806
132Myopathic facies (HP:0002058)1.65174278
133Abnormality of the nasal mucosa (HP:0000433)1.64361836
134Osteolytic defects of the hand bones (HP:0009699)1.64007255
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.64007255
136Cheilitis (HP:0100825)1.63836211
137Distal lower limb muscle weakness (HP:0009053)1.63387917
138Pili torti (HP:0003777)1.62791735
139Rhabdomyolysis (HP:0003201)1.61429538
140Neonatal death (HP:0003811)1.59437581
141Difficulty climbing stairs (HP:0003551)1.59352674
142Progressive muscle weakness (HP:0003323)1.59308283
143Aortic dissection (HP:0002647)1.56383096
144Inflammation of the large intestine (HP:0002037)1.56348149
145Late onset (HP:0003584)1.55010346
146Elevated erythrocyte sedimentation rate (HP:0003565)1.54968719
147Colitis (HP:0002583)1.53895078
148Abnormality of T cell physiology (HP:0011840)1.53552104
149Woolly hair (HP:0002224)1.51992288
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.51492008
151Hyperacusis (HP:0010780)1.50910498
152Thin bony cortex (HP:0002753)1.50579701
153Bladder diverticulum (HP:0000015)1.50072441
154Abnormality of fatty-acid metabolism (HP:0004359)1.49305941
155Bowed forearm bones (HP:0003956)1.49271998
156Bowing of the arm (HP:0006488)1.49271998
157Abnormal platelet function (HP:0011869)1.49032308
158Impaired platelet aggregation (HP:0003540)1.49032308
159Vertebral clefting (HP:0008428)1.48989857
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.48693291
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.48693291
162Dilated cardiomyopathy (HP:0001644)1.48361954
163Myoglobinuria (HP:0002913)1.47892958
164Ragged-red muscle fibers (HP:0003200)1.47856528
165Type 1 muscle fiber predominance (HP:0003803)1.47803166
166Muscle fiber splitting (HP:0003555)1.46960105
167Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.46276452
168Vertebral hypoplasia (HP:0008417)1.46276452
169Mitral valve prolapse (HP:0001634)1.46260761
170Breast hypoplasia (HP:0003187)1.45185382
171Abnormality of glutamine family amino acid metabolism (HP:0010902)1.45127977
172Joint stiffness (HP:0001387)1.44792121
173Aortic aneurysm (HP:0004942)1.44621956
174Xanthomatosis (HP:0000991)1.44245649
175Abnormality of the peritoneum (HP:0002585)1.42962070
176Soft skin (HP:0000977)1.42454840
177Milia (HP:0001056)1.41829501
178Myocardial infarction (HP:0001658)1.41803448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.58039115
2SMG13.46014614
3ERN13.04947816
4PKN22.92148645
5MAP3K102.62502308
6NME22.37068314
7EEF2K2.10954607
8TIE12.00896964
9PRPF4B2.00853640
10BCKDK1.97119873
11TTN1.84860198
12VRK21.80561972
13KDR1.76174466
14MAP4K11.75964206
15FLT31.71067257
16TAOK31.61613144
17LRRK21.59186814
18NEK21.58808654
19PAK41.58266296
20MAPKAPK31.56819840
21EPHB21.56800205
22RPS6KB21.53125631
23STK101.48831221
24RPS6KA41.48665903
25TGFBR21.44702122
26EPHA21.43746588
27MAP2K21.43468801
28MAP3K111.42110781
29TESK21.39902470
30PIM21.37146832
31TLK11.35921938
32BUB11.35369632
33PIK3CA1.30858710
34NEK11.30561022
35SIK11.28116328
36RIPK11.24764702
37ILK1.22682044
38ARAF1.19859437
39PRKD31.19854703
40MAP2K31.18419598
41PTK61.17016288
42TBK11.14704175
43FGFR41.13947255
44ICK1.13255601
45RPS6KA21.12070747
46WEE11.11182477
47MAP3K81.08454306
48TYK21.07838025
49CDK71.02724607
50DYRK1B0.99978292
51PDGFRA0.98886842
52BMX0.98123531
53CDK120.96175127
54DYRK30.95991114
55PASK0.93317240
56CDK40.93002010
57TAOK10.92909167
58PDK20.92384077
59PIM10.90238296
60KIT0.89334489
61TGFBR10.88586004
62LIMK10.84228397
63MAPK110.83998308
64MATK0.83836458
65DDR20.83702933
66ABL20.83559763
67MAP3K10.83017069
68PDPK10.82347013
69AURKB0.82172396
70MTOR0.80067473
71MAP3K30.79102336
72TESK10.78326414
73ZAP700.76865129
74IKBKB0.75450675
75DMPK0.75425370
76GRK60.74782340
77JAK30.74687980
78CDC42BPA0.74595048
79TTK0.72385617
80LMTK20.72308491
81CHUK0.68424292
82MARK30.68070604
83MAP3K60.67433359
84BTK0.67125644
85SIK30.66257572
86BRAF0.66009436
87STK40.64774504
88HIPK20.64061519
89AURKA0.62419179
90CDK60.62345943
91SCYL20.62117941
92MAP3K70.61309975
93PRKG20.61074880
94STK38L0.61029911
95BLK0.61028363
96IRAK30.58795745
97PAK20.58740650
98CSK0.58247924
99MYLK0.58033168
100PLK10.57704334
101MAP3K130.57604375
102TEC0.56708070
103DAPK30.56597294
104DAPK10.56189844
105PTK20.55785843
106CSF1R0.55124676
107MAPK150.52400075
108NEK90.52064664
109TRPM70.51833090
110PAK10.51449226
111MST1R0.50187785
112TAOK20.50058163
113PRKCI0.49802428
114MAPKAPK20.49011513
115IRAK40.48659695
116IRAK20.48370645
117EPHB10.47966498
118EIF2AK10.47816583
119RPS6KA60.47797711
120RPS6KC10.46952808
121RPS6KL10.46952808
122PRKD20.45869719
123AKT20.45767807
124MAP3K140.45376377
125CDC70.41261338
126PRKD10.40956254
127MET0.40516013
128TNK20.38859030
129MARK20.38005602
130CDK80.36694372
131PBK0.34541546
132MOS0.33605332

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.20296148
2DNA replication_Homo sapiens_hsa030302.78253783
3Lysosome_Homo sapiens_hsa041422.26309424
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06274534
5Mismatch repair_Homo sapiens_hsa034302.01966517
6Base excision repair_Homo sapiens_hsa034102.00998392
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76439777
8Sulfur relay system_Homo sapiens_hsa041221.71175014
9Non-small cell lung cancer_Homo sapiens_hsa052231.55476316
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48500036
11One carbon pool by folate_Homo sapiens_hsa006701.48294479
12Fatty acid degradation_Homo sapiens_hsa000711.45587324
13p53 signaling pathway_Homo sapiens_hsa041151.44153164
14Folate biosynthesis_Homo sapiens_hsa007901.40586774
15VEGF signaling pathway_Homo sapiens_hsa043701.40399167
16Carbon metabolism_Homo sapiens_hsa012001.40366048
17Caffeine metabolism_Homo sapiens_hsa002321.34717901
18Spliceosome_Homo sapiens_hsa030401.33829962
19Pancreatic cancer_Homo sapiens_hsa052121.31878327
20Small cell lung cancer_Homo sapiens_hsa052221.29378429
21Pentose phosphate pathway_Homo sapiens_hsa000301.28384940
22Tyrosine metabolism_Homo sapiens_hsa003501.27229293
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.26237446
24Biosynthesis of amino acids_Homo sapiens_hsa012301.25902439
25Bladder cancer_Homo sapiens_hsa052191.25248275
26Cell cycle_Homo sapiens_hsa041101.24747516
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21603593
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.20756865
29Selenocompound metabolism_Homo sapiens_hsa004501.20689879
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17689830
31Galactose metabolism_Homo sapiens_hsa000521.15616742
32Homologous recombination_Homo sapiens_hsa034401.15352299
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14801188
34Endometrial cancer_Homo sapiens_hsa052131.11940418
35Chronic myeloid leukemia_Homo sapiens_hsa052201.10886939
36Notch signaling pathway_Homo sapiens_hsa043301.10146358
37Pyrimidine metabolism_Homo sapiens_hsa002401.09381394
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.05208194
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05085050
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02482026
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00879955
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00841022
43Fructose and mannose metabolism_Homo sapiens_hsa000511.00770466
44mTOR signaling pathway_Homo sapiens_hsa041501.00048270
45RNA transport_Homo sapiens_hsa030130.99788577
46Acute myeloid leukemia_Homo sapiens_hsa052210.99671220
47Vibrio cholerae infection_Homo sapiens_hsa051100.97700820
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96813246
49N-Glycan biosynthesis_Homo sapiens_hsa005100.96207399
50Antigen processing and presentation_Homo sapiens_hsa046120.94087756
51Tryptophan metabolism_Homo sapiens_hsa003800.93698297
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90629926
53Fat digestion and absorption_Homo sapiens_hsa049750.89688125
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89356172
55Apoptosis_Homo sapiens_hsa042100.89272511
56Glutathione metabolism_Homo sapiens_hsa004800.89266483
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88927385
58Leishmaniasis_Homo sapiens_hsa051400.88355988
59Phenylalanine metabolism_Homo sapiens_hsa003600.87445131
60Hepatitis C_Homo sapiens_hsa051600.87236782
61Nucleotide excision repair_Homo sapiens_hsa034200.87067272
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87008543
63Thyroid cancer_Homo sapiens_hsa052160.86931811
64Prion diseases_Homo sapiens_hsa050200.85019657
65Other glycan degradation_Homo sapiens_hsa005110.84693441
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83720329
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82230304
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.81836905
69Legionellosis_Homo sapiens_hsa051340.81297187
70Herpes simplex infection_Homo sapiens_hsa051680.81164198
71PPAR signaling pathway_Homo sapiens_hsa033200.80425932
72Toxoplasmosis_Homo sapiens_hsa051450.78826827
73Lysine degradation_Homo sapiens_hsa003100.77267575
74Endocytosis_Homo sapiens_hsa041440.76977775
75Osteoclast differentiation_Homo sapiens_hsa043800.76662434
76Insulin signaling pathway_Homo sapiens_hsa049100.75832499
77Adherens junction_Homo sapiens_hsa045200.74957705
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74556112
79ECM-receptor interaction_Homo sapiens_hsa045120.74293526
80Primary immunodeficiency_Homo sapiens_hsa053400.74045498
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73585806
82HTLV-I infection_Homo sapiens_hsa051660.73072521
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72510339
84Arginine and proline metabolism_Homo sapiens_hsa003300.70916633
85AMPK signaling pathway_Homo sapiens_hsa041520.70627738
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.70273195
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.70265624
88Shigellosis_Homo sapiens_hsa051310.69797942
89Prostate cancer_Homo sapiens_hsa052150.69274730
90Proteasome_Homo sapiens_hsa030500.69233370
91Salmonella infection_Homo sapiens_hsa051320.68959143
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68731676
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67745880
94Proteoglycans in cancer_Homo sapiens_hsa052050.67717107
95Viral myocarditis_Homo sapiens_hsa054160.67231843
96TNF signaling pathway_Homo sapiens_hsa046680.66792006
97Fatty acid metabolism_Homo sapiens_hsa012120.66658147
98Sphingolipid metabolism_Homo sapiens_hsa006000.65447786
99Viral carcinogenesis_Homo sapiens_hsa052030.65421721
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64678529
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.64528675
102Focal adhesion_Homo sapiens_hsa045100.64476229
103MicroRNAs in cancer_Homo sapiens_hsa052060.63471510
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63302108
105Propanoate metabolism_Homo sapiens_hsa006400.62365644
106Basal cell carcinoma_Homo sapiens_hsa052170.60956066
107Measles_Homo sapiens_hsa051620.60625048
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59888000
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.58339568
110HIF-1 signaling pathway_Homo sapiens_hsa040660.57910961
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55954753
112Protein digestion and absorption_Homo sapiens_hsa049740.55471880
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55407666
114Insulin resistance_Homo sapiens_hsa049310.55081699
115Glioma_Homo sapiens_hsa052140.54891167
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.54597153
117RNA polymerase_Homo sapiens_hsa030200.54405249
118Starch and sucrose metabolism_Homo sapiens_hsa005000.54207782
119Pyruvate metabolism_Homo sapiens_hsa006200.53899764
120Tuberculosis_Homo sapiens_hsa051520.53095456
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.52929153
122Fatty acid elongation_Homo sapiens_hsa000620.50537377
123Epstein-Barr virus infection_Homo sapiens_hsa051690.50007027
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49687313
125Renin-angiotensin system_Homo sapiens_hsa046140.49200716
126Amoebiasis_Homo sapiens_hsa051460.48195950
127Inositol phosphate metabolism_Homo sapiens_hsa005620.47825144
128B cell receptor signaling pathway_Homo sapiens_hsa046620.47781028
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46936122
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45196691
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44168056
132Influenza A_Homo sapiens_hsa051640.43865633
133ErbB signaling pathway_Homo sapiens_hsa040120.43863191
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43746831
135Renal cell carcinoma_Homo sapiens_hsa052110.43219943
136Hepatitis B_Homo sapiens_hsa051610.43094863
137Colorectal cancer_Homo sapiens_hsa052100.42941270
138Hippo signaling pathway_Homo sapiens_hsa043900.42812872
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42669592
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.41839686
141Platelet activation_Homo sapiens_hsa046110.40224743
142Prolactin signaling pathway_Homo sapiens_hsa049170.39873218
143Sulfur metabolism_Homo sapiens_hsa009200.39842977
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.39256338

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