ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of integrated proviral latency (GO:0075713)	7.36035617
2	establishment of viral latency (GO:0019043)	6.40147388
3	DNA unwinding involved in DNA replication (GO:0006268)	6.32247907
4	protein maturation by protein folding (GO:0022417)	5.65725926
5	heterochromatin organization (GO:0070828)	5.55480857
6	regulation of translational termination (GO:0006449)	4.57585091
7	DNA strand elongation involved in DNA replication (GO:0006271)	4.31638314
8	nuclear envelope reassembly (GO:0031468)	4.25431795
9	mitotic nuclear envelope reassembly (GO:0007084)	4.25431795
10	telomere maintenance via semi-conservative replication (GO:0032201)	4.20534432
11	DNA strand elongation (GO:0022616)	4.20169803
12	COPI coating of Golgi vesicle (GO:0048205)	3.97009324
13	Golgi transport vesicle coating (GO:0048200)	3.97009324
14	protein localization to chromosome, centromeric region (GO:0071459)	3.96884904
15	protein localization to kinetochore (GO:0034501)	3.85503399
16	mitotic sister chromatid segregation (GO:0000070)	3.73811448
17	mitotic metaphase plate congression (GO:0007080)	3.68368572
18	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.57525738
19	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.57055016
20	mitotic chromosome condensation (GO:0007076)	3.53625567
21	formation of translation preinitiation complex (GO:0001731)	3.50131297
22	peptidyl-arginine omega-N-methylation (GO:0035247)	3.38791437
23	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.35040148
24	viral mRNA export from host cell nucleus (GO:0046784)	3.33957565
25	transcription-coupled nucleotide-excision repair (GO:0006283)	3.32944285
26	sister chromatid segregation (GO:0000819)	3.32363303
27	maturation of SSU-rRNA (GO:0030490)	3.30761295
28	telomere maintenance via recombination (GO:0000722)	3.28754803
29	mitotic recombination (GO:0006312)	3.22327585
30	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.21858750
31	wound healing, spreading of epidermal cells (GO:0035313)	3.19477670
32	protein retention in ER lumen (GO:0006621)	3.15579985
33	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.15186347
34	chromatin assembly (GO:0031497)	3.12207026
35	ribosome assembly (GO:0042255)	3.11051976
36	base-excision repair (GO:0006284)	3.10285508
37	histone arginine methylation (GO:0034969)	3.05482453
38	proteasome assembly (GO:0043248)	3.05089892
39	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.03290241
40	nucleobase-containing small molecule interconversion (GO:0015949)	3.01663784
41	DNA replication initiation (GO:0006270)	3.01623398
42	negative regulation of ligase activity (GO:0051352)	2.98695662
43	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.98695662
44	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.96128654
45	metaphase plate congression (GO:0051310)	2.95343435
46	telomere maintenance via telomere lengthening (GO:0010833)	2.95262138
47	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.91808564
48	mitotic G1 DNA damage checkpoint (GO:0031571)	2.91600698
49	regulation of cell aging (GO:0090342)	2.91427056
50	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.90210265
51	ribosomal large subunit biogenesis (GO:0042273)	2.88109462
52	positive regulation of actin filament depolymerization (GO:0030836)	2.88093962
53	7-methylguanosine mRNA capping (GO:0006370)	2.81699634
54	pentose-phosphate shunt (GO:0006098)	2.81137899
55	proline biosynthetic process (GO:0006561)	2.80188694
56	barbed-end actin filament capping (GO:0051016)	2.80087424
57	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.79730703
58	transcription from RNA polymerase I promoter (GO:0006360)	2.74629877
59	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.73660938
60	RNA capping (GO:0036260)	2.71730109
61	7-methylguanosine RNA capping (GO:0009452)	2.71730109
62	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.69296924
63	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.69236142
64	muscle cell migration (GO:0014812)	2.68325863
65	ribosome biogenesis (GO:0042254)	2.68228882
66	establishment of chromosome localization (GO:0051303)	2.67273655
67	spliceosomal snRNP assembly (GO:0000387)	2.67045149
68	ribonucleoprotein complex biogenesis (GO:0022613)	2.66295617
69	negative regulation of gene silencing (GO:0060969)	2.64207234
70	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.63245073
71	peptidyl-arginine N-methylation (GO:0035246)	2.62983769
72	peptidyl-arginine methylation (GO:0018216)	2.62983769
73	ribosomal small subunit biogenesis (GO:0042274)	2.62649204
74	protein-DNA complex disassembly (GO:0032986)	2.61718052
75	nucleosome disassembly (GO:0006337)	2.61718052
76	sequestering of actin monomers (GO:0042989)	2.61239825
77	positive regulation of viral transcription (GO:0050434)	2.57263560
78	wound healing, spreading of cells (GO:0044319)	2.56100353
79	UV protection (GO:0009650)	2.55220423
80	regulation of metalloenzyme activity (GO:0048552)	2.54069068
81	glucose catabolic process (GO:0006007)	2.53056978
82	GDP-mannose metabolic process (GO:0019673)	2.52449773
83	regulation of mitochondrial translation (GO:0070129)	2.52296623
84	DNA replication checkpoint (GO:0000076)	2.51015662
85	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)	2.50625723
86	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.50451652
87	mitotic nuclear envelope disassembly (GO:0007077)	2.49721919
88	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.48989318
89	mitotic G1/S transition checkpoint (GO:0044819)	2.48143034
90	NADPH regeneration (GO:0006740)	2.47258286
91	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.45748175
92	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.45412888
93	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.45412888
94	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.44528431
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.44528431
96	deoxyribonucleotide biosynthetic process (GO:0009263)	2.43853742
97	chromosome condensation (GO:0030261)	2.43783736
98	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.42921357
99	folic acid-containing compound biosynthetic process (GO:0009396)	2.42474512
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.41991447

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.16172518
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.90870792
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.27276286
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.26367574
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.22076832
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.06952359
7	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.02837229
8	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.82234897
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.66579607
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.45816947
11	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.29661962
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.26764125
13	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.25514390
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21723124
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.17502543
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16221671
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.15272109
18	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.14607222
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10176499
20	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.10119639
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.09447201
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.05093640
23	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.97920437
24	MYC_22102868_ChIP-Seq_BL_Human	1.95812001
25	ZNF263_19887448_ChIP-Seq_K562_Human	1.93282847
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.90575552
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.90365107
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.79844786
29	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.75693104
30	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73998445
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72625678
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.71573798
33	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.69577916
34	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.67716354
35	VDR_21846776_ChIP-Seq_THP-1_Human	1.65176348
36	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.64146279
37	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61168706
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60621238
39	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.57215602
40	AR_21909140_ChIP-Seq_LNCAP_Human	1.56631672
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.54987027
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.51460140
43	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.51361318
44	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.48155908
45	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.47220367
46	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.45854974
47	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.44275561
48	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.43551924
49	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.42968838
50	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.40824689
51	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.39282266
52	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.36372736
53	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.36133114
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.35623181
55	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.35282155
56	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.34081228
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31624729
58	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.31030641
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.30828474
60	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28186579
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25999371
62	KDM5A_27292631_Chip-Seq_BREAST_Human	1.23881984
63	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.21900554
64	ATF3_27146783_Chip-Seq_COLON_Human	1.21861172
65	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.20107504
66	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.18691698
67	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.14554905
68	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13742131
69	LXR_22292898_ChIP-Seq_THP-1_Human	1.12887603
70	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12393373
71	RACK7_27058665_Chip-Seq_MCF-7_Human	1.11542349
72	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.11535121
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.10725031
74	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.09921852
75	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.09427850
76	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.09316869
77	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.08948329
78	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.06201521
79	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06054711
80	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.05471801
81	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.04790761
82	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04698769
83	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03339748
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02416647
85	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.02345299
86	TFEB_21752829_ChIP-Seq_HELA_Human	1.01953275
87	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.98598966
88	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98476983
89	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.96064509
90	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.95915853
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95696034
92	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.94854957
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.94767982
94	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.94462372
95	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.93930880
96	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93896791
97	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93865268
98	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.93825520
99	P68_20966046_ChIP-Seq_HELA_Human	0.93269560
100	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.93229072

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002877_abnormal_melanocyte_morpholog	3.79050739
2	MP0003111_abnormal_nucleus_morphology	3.36635101
3	MP0004957_abnormal_blastocyst_morpholog	3.33338816
4	MP0003693_abnormal_embryo_hatching	3.26039609
5	MP0005257_abnormal_intraocular_pressure	2.92979937
6	MP0003566_abnormal_cell_adhesion	2.80071281
7	MP0010030_abnormal_orbit_morphology	2.78000235
8	MP0010094_abnormal_chromosome_stability	2.67281126
9	MP0003077_abnormal_cell_cycle	2.55226251
10	MP0008932_abnormal_embryonic_tissue	2.51351541
11	MP0008007_abnormal_cellular_replicative	2.39206243
12	MP0008057_abnormal_DNA_replication	2.31181542
13	MP0004185_abnormal_adipocyte_glucose	2.26631284
14	MP0003786_premature_aging	2.20215326
15	MP0005670_abnormal_white_adipose	2.06766014
16	MP0003705_abnormal_hypodermis_morpholog	2.03392438
17	MP0003191_abnormal_cellular_cholesterol	2.00320397
18	MP0005451_abnormal_body_composition	1.98664940
19	MP0000537_abnormal_urethra_morphology	1.94825148
20	MP0008058_abnormal_DNA_repair	1.93005230
21	MP0005623_abnormal_meninges_morphology	1.84522496
22	MP0000350_abnormal_cell_proliferation	1.79771046
23	MP0000858_altered_metastatic_potential	1.77134724
24	MP0001730_embryonic_growth_arrest	1.75300612
25	MP0004233_abnormal_muscle_weight	1.70200379
26	MP0003950_abnormal_plasma_membrane	1.67224701
27	MP0001542_abnormal_bone_strength	1.66797681
28	MP0009333_abnormal_splenocyte_physiolog	1.60135405
29	MP0005501_abnormal_skin_physiology	1.59440805
30	MP0009053_abnormal_anal_canal	1.59062544
31	MP0000003_abnormal_adipose_tissue	1.55275381
32	MP0004272_abnormal_basement_membrane	1.54275428
33	MP0000751_myopathy	1.53618678
34	MP0003315_abnormal_perineum_morphology	1.47456701
35	MP0002080_prenatal_lethality	1.43784426
36	MP0000750_abnormal_muscle_regeneration	1.43721579
37	MP0009278_abnormal_bone_marrow	1.39869753
38	MP0000490_abnormal_crypts_of	1.33191970
39	MP0001697_abnormal_embryo_size	1.30717928
40	MP0000358_abnormal_cell_content/	1.29950570
41	MP0006035_abnormal_mitochondrial_morpho	1.29058424
42	MP0005076_abnormal_cell_differentiation	1.28956969
43	MP0001672_abnormal_embryogenesis/_devel	1.25033694
44	MP0005380_embryogenesis_phenotype	1.25033694
45	MP0000313_abnormal_cell_death	1.23558926
46	MP0003123_paternal_imprinting	1.22327293
47	MP0002060_abnormal_skin_morphology	1.19516434
48	MP0002234_abnormal_pharynx_morphology	1.18652199
49	MP0002019_abnormal_tumor_incidence	1.17920078
50	MP0003984_embryonic_growth_retardation	1.17878150
51	MP0008260_abnormal_autophagy	1.15346122
52	MP0002085_abnormal_embryonic_tissue	1.14496406
53	MP0002796_impaired_skin_barrier	1.09601985
54	MP0002396_abnormal_hematopoietic_system	1.09390315
55	MP0001849_ear_inflammation	1.08866518
56	MP0002088_abnormal_embryonic_growth/wei	1.08716645
57	MP0009672_abnormal_birth_weight	1.08409612
58	MP0003806_abnormal_nucleotide_metabolis	1.07429788
59	MP0000749_muscle_degeneration	1.06145043
60	MP0005621_abnormal_cell_physiology	1.01842915
61	MP0001243_abnormal_dermal_layer	1.00590500
62	MP0003453_abnormal_keratinocyte_physiol	1.00475610
63	MP0003718_maternal_effect	0.99955585
64	MP0005058_abnormal_lysosome_morphology	0.96912857
65	MP0002177_abnormal_outer_ear	0.96638531
66	MP0000762_abnormal_tongue_morphology	0.96424513
67	MP0002086_abnormal_extraembryonic_tissu	0.95497695
68	MP0001346_abnormal_lacrimal_gland	0.95455715
69	MP0005384_cellular_phenotype	0.95313097
70	MP0004197_abnormal_fetal_growth/weight/	0.91989477
71	MP0001853_heart_inflammation	0.90447374
72	MP0009840_abnormal_foam_cell	0.90184408
73	MP0008438_abnormal_cutaneous_collagen	0.89775807
74	MP0005360_urolithiasis	0.89260302
75	MP0005165_increased_susceptibility_to	0.89154643
76	MP0005330_cardiomyopathy	0.88743318
77	MP0010368_abnormal_lymphatic_system	0.87921023
78	MP0003763_abnormal_thymus_physiology	0.87119904
79	MP0003436_decreased_susceptibility_to	0.86353922
80	MP0002084_abnormal_developmental_patter	0.85905986
81	MP0001299_abnormal_eye_distance/	0.83783950
82	MP0005023_abnormal_wound_healing	0.83677356
83	MP0001216_abnormal_epidermal_layer	0.83112392
84	MP0004510_myositis	0.82507673
85	MP0002254_reproductive_system_inflammat	0.82352940
86	MP0010771_integument_phenotype	0.79627193
87	MP0000733_abnormal_muscle_development	0.78158591
88	MP0009697_abnormal_copulation	0.76729022
89	MP0000534_abnormal_ureter_morphology	0.76223314
90	MP0005375_adipose_tissue_phenotype	0.75873174
91	MP0003115_abnormal_respiratory_system	0.75604572
92	MP0003091_abnormal_cell_migration	0.74837403
93	MP0003942_abnormal_urinary_system	0.73312604
94	MP0005666_abnormal_adipose_tissue	0.73181148
95	MP0003943_abnormal_hepatobiliary_system	0.72992006
96	MP0004808_abnormal_hematopoietic_stem	0.72263104
97	MP0000516_abnormal_urinary_system	0.71312059
98	MP0005367_renal/urinary_system_phenotyp	0.71312059
99	MP0010352_gastrointestinal_tract_polyps	0.69587882
100	MP0005197_abnormal_uvea_morphology	0.68102144

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced subcutaneous adipose tissue (HP:0003758)	4.16689709
2	Hyperacusis (HP:0010780)	3.71382095
3	Premature rupture of membranes (HP:0001788)	3.68023719
4	Rough bone trabeculation (HP:0100670)	3.64849275
5	Long palpebral fissure (HP:0000637)	3.24632663
6	Trismus (HP:0000211)	3.17859051
7	Upper limb muscle weakness (HP:0003484)	3.14359678
8	Entropion (HP:0000621)	3.14087515
9	Insulin resistance (HP:0000855)	3.13905077
10	Insomnia (HP:0100785)	3.12024777
11	Vertebral compression fractures (HP:0002953)	2.85919707
12	Osteolytic defects of the hand bones (HP:0009699)	2.82990067
13	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.82990067
14	Progressive muscle weakness (HP:0003323)	2.81941611
15	Achilles tendon contracture (HP:0001771)	2.80149808
16	Broad face (HP:0000283)	2.75359453
17	Overriding aorta (HP:0002623)	2.72793205
18	Short nail (HP:0001799)	2.64876741
19	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.63503780
20	Microglossia (HP:0000171)	2.62079205
21	Abnormal number of erythroid precursors (HP:0012131)	2.59364126
22	Sparse eyelashes (HP:0000653)	2.58726971
23	Abnormal trabecular bone morphology (HP:0100671)	2.57575116
24	Distal lower limb amyotrophy (HP:0008944)	2.53694557
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.50219824
26	Abnormality of the distal phalanges of the toes (HP:0010182)	2.50039295
27	Abnormal gallbladder physiology (HP:0012438)	2.49803392
28	Cholecystitis (HP:0001082)	2.49803392
29	Increased connective tissue (HP:0009025)	2.47344253
30	Spinal rigidity (HP:0003306)	2.45607553
31	Glucose intolerance (HP:0000833)	2.45063057
32	Distal upper limb amyotrophy (HP:0007149)	2.41759356
33	Upper limb amyotrophy (HP:0009129)	2.41759356
34	Abnormality of the Achilles tendon (HP:0005109)	2.31296408
35	Reticulocytopenia (HP:0001896)	2.31054660
36	Hand muscle atrophy (HP:0009130)	2.29276117
37	Type I transferrin isoform profile (HP:0003642)	2.29097988
38	Proximal placement of thumb (HP:0009623)	2.25961055
39	Selective tooth agenesis (HP:0001592)	2.25571184
40	Abnormality of the umbilical cord (HP:0010881)	2.25352947
41	Shoulder girdle muscle weakness (HP:0003547)	2.24549343
42	Poikiloderma (HP:0001029)	2.23651680
43	Generalized amyotrophy (HP:0003700)	2.23547580
44	Elbow flexion contracture (HP:0002987)	2.22918234
45	Deviation of the thumb (HP:0009603)	2.21435507
46	Increased nuchal translucency (HP:0010880)	2.19345931
47	Elfin facies (HP:0004428)	2.19110086
48	Late onset (HP:0003584)	2.19030000
49	Chromsome breakage (HP:0040012)	2.17604048
50	Anteriorly placed anus (HP:0001545)	2.16297092
51	Hypergonadotropic hypogonadism (HP:0000815)	2.16075728
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.15986562
53	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.15986562
54	Pelvic girdle muscle weakness (HP:0003749)	2.11208284
55	Distal lower limb muscle weakness (HP:0009053)	2.10900667
56	Spastic diplegia (HP:0001264)	2.10424517
57	Unilateral renal agenesis (HP:0000122)	2.08868057
58	Secondary amenorrhea (HP:0000869)	2.08755801
59	Onycholysis (HP:0001806)	2.07187625
60	Breast hypoplasia (HP:0003187)	2.07123719
61	Acanthosis nigricans (HP:0000956)	2.06653854
62	Abnormality of carpal bone ossification (HP:0006257)	2.04661254
63	Large eyes (HP:0001090)	2.02119343
64	Difficulty climbing stairs (HP:0003551)	2.01563761
65	Adrenal hypoplasia (HP:0000835)	2.01527527
66	Ureteral duplication (HP:0000073)	1.99037300
67	Hepatocellular necrosis (HP:0001404)	1.97896481
68	Abnormal ossification of hand bones (HP:0005921)	1.94509342
69	Orthostatic hypotension (HP:0001278)	1.92923861
70	Renal duplication (HP:0000075)	1.91294708
71	Microvesicular hepatic steatosis (HP:0001414)	1.91055493
72	Prominent metopic ridge (HP:0005487)	1.90985572
73	Abnormality of glycolysis (HP:0004366)	1.90187744
74	Natal tooth (HP:0000695)	1.90023804
75	Increased serum pyruvate (HP:0003542)	1.87257667
76	Decreased subcutaneous fat (HP:0001002)	1.87214572
77	Abnormalities of placenta or umbilical cord (HP:0001194)	1.87112014
78	Limb-girdle muscle atrophy (HP:0003797)	1.87099640
79	Ragged-red muscle fibers (HP:0003200)	1.86200871
80	Abnormality of the hip-girdle musculature (HP:0001445)	1.84670359
81	Abnormality of the musculature of the pelvis (HP:0001469)	1.84670359
82	Nail dystrophy (HP:0008404)	1.84449768
83	Progressive hearing impairment (HP:0001730)	1.84361889
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.82338124
85	Short clavicles (HP:0000894)	1.75380054
86	Protrusio acetabuli (HP:0003179)	1.75039511
87	Abnormal protein glycosylation (HP:0012346)	1.74277538
88	Abnormal glycosylation (HP:0012345)	1.74277538
89	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.74277538
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.74277538
91	Reduced antithrombin III activity (HP:0001976)	1.73718063
92	Atrophic scars (HP:0001075)	1.73694598
93	Impaired platelet aggregation (HP:0003540)	1.72601729
94	Abnormal platelet function (HP:0011869)	1.72601729
95	Myocardial infarction (HP:0001658)	1.72572465
96	Abnormal number of incisors (HP:0011064)	1.72503556
97	Microretrognathia (HP:0000308)	1.69777352
98	Overlapping toe (HP:0001845)	1.67862870
99	Patellar dislocation (HP:0002999)	1.66017984
100	Abnormality of subcutaneous fat tissue (HP:0001001)	1.65019242

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.82844473
2	TESK2	4.48179220
3	BUB1	3.96290374
4	NME2	3.90375723
5	TESK1	3.48060374
6	EPHA2	3.03912888
7	CDK8	2.90017742
8	LIMK1	2.65416427
9	SMG1	2.45623271
10	IRAK3	2.20865060
11	KDR	2.17102821
12	CDK12	1.91961206
13	PAK4	1.89729100
14	PLK4	1.72691938
15	LMTK2	1.66417969
16	CDC7	1.65621938
17	ICK	1.61978633
18	MST1R	1.60932833
19	ARAF	1.57790138
20	BCKDK	1.51726951
21	TAOK2	1.50574715
22	MST4	1.49611565
23	NEK1	1.49197649
24	STK10	1.45247007
25	ERBB4	1.37268215
26	ERN1	1.36023487
27	PIM2	1.35197136
28	TRIB3	1.31608559
29	SRPK1	1.30062740
30	CDK7	1.21396707
31	EIF2AK1	1.20682884
32	SIK1	1.17161324
33	TAF1	1.15582033
34	AURKA	1.13722453
35	MAP3K10	1.09992423
36	DAPK1	1.09028548
37	PRPF4B	1.08830698
38	NEK2	1.07721230
39	ILK	1.06366044
40	MAP3K8	1.05238112
41	PTK2	1.04940809
42	FLT3	1.04609402
43	BRSK1	1.04576031
44	VRK1	1.02391489
45	RPS6KB2	0.98890124
46	TTK	0.97441831
47	CHEK2	0.95498259
48	CDK9	0.89807618
49	MAP3K11	0.88604695
50	AURKB	0.84095231
51	SCYL2	0.81759960
52	BRAF	0.76942815
53	ABL2	0.74646745
54	MET	0.74106483
55	MOS	0.73325008
56	MAP2K2	0.73007826
57	EEF2K	0.72318984
58	PLK1	0.69278933
59	LRRK2	0.68804794
60	PAK1	0.68215978
61	STK16	0.65289355
62	HIPK2	0.64960918
63	TSSK6	0.63824647
64	WEE1	0.60304168
65	ATR	0.58087259
66	MAP3K12	0.57778775
67	SIK3	0.57244779
68	PBK	0.57135442
69	STK4	0.56690965
70	PLK3	0.56304635
71	DAPK3	0.54764775
72	NUAK1	0.54055348
73	EPHB1	0.54013106
74	PRKCI	0.52419865
75	CDK4	0.51496071
76	PTK6	0.51005419
77	MAP2K7	0.50499289
78	EIF2AK2	0.50363369
79	EPHB2	0.50176903
80	TTN	0.48496718
81	PRKD2	0.48177140
82	CHEK1	0.46540288
83	CSNK1G3	0.46178375
84	BMX	0.46021319
85	RPS6KA4	0.42170891
86	CDK11A	0.40765745
87	AKT2	0.37426203
88	SIK2	0.35596602
89	CDK15	0.35504521
90	DMPK	0.35030041
91	CDK18	0.34077673
92	CSNK1A1L	0.33824483
93	NTRK1	0.33643743
94	CSNK2A2	0.33116906
95	DYRK3	0.32664467
96	LATS2	0.31171385
97	MAPKAPK2	0.30553042
98	MTOR	0.30543469
99	CDK14	0.30247408
100	CDK19	0.30098533

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.67301574
2	Proteasome_Homo sapiens_hsa03050	3.56892346
3	Mismatch repair_Homo sapiens_hsa03430	3.06099699
4	Base excision repair_Homo sapiens_hsa03410	3.05929462
5	Nucleotide excision repair_Homo sapiens_hsa03420	2.71204000
6	Spliceosome_Homo sapiens_hsa03040	2.39095985
7	Ribosome_Homo sapiens_hsa03010	2.38747182
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.32369620
9	Pyrimidine metabolism_Homo sapiens_hsa00240	2.32169590
10	RNA polymerase_Homo sapiens_hsa03020	2.21039760
11	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.16401054
12	Sulfur relay system_Homo sapiens_hsa04122	1.96291347
13	Cell cycle_Homo sapiens_hsa04110	1.94685016
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.93661325
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.86011862
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.84252676
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.83171472
18	RNA transport_Homo sapiens_hsa03013	1.82438199
19	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.78750885
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.77437375
21	Homologous recombination_Homo sapiens_hsa03440	1.66807779
22	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.57926202
23	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.53976847
24	Folate biosynthesis_Homo sapiens_hsa00790	1.48249479
25	Shigellosis_Homo sapiens_hsa05131	1.44105207
26	Galactose metabolism_Homo sapiens_hsa00052	1.41811478
27	Bladder cancer_Homo sapiens_hsa05219	1.36025744
28	Basal transcription factors_Homo sapiens_hsa03022	1.35865387
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.35581242
30	Huntingtons disease_Homo sapiens_hsa05016	1.35079771
31	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.34755146
32	Parkinsons disease_Homo sapiens_hsa05012	1.33926187
33	One carbon pool by folate_Homo sapiens_hsa00670	1.32203827
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.26660992
35	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.25823372
36	Fatty acid elongation_Homo sapiens_hsa00062	1.24645092
37	Carbon metabolism_Homo sapiens_hsa01200	1.24523011
38	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.22220977
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.15189683
40	Glutathione metabolism_Homo sapiens_hsa00480	1.15048312
41	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.09095178
42	Thyroid cancer_Homo sapiens_hsa05216	1.07599606
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07371468
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.05402762
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.03983924
46	p53 signaling pathway_Homo sapiens_hsa04115	1.02265288
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01513923
48	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.00315590
49	Apoptosis_Homo sapiens_hsa04210	0.99976875
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.99694121
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94949284
52	Purine metabolism_Homo sapiens_hsa00230	0.93608930
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92928277
54	Alzheimers disease_Homo sapiens_hsa05010	0.92555149
55	Vibrio cholerae infection_Homo sapiens_hsa05110	0.86324816
56	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.80593386
57	RNA degradation_Homo sapiens_hsa03018	0.79185621
58	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.75167186
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.72964061
60	Small cell lung cancer_Homo sapiens_hsa05222	0.71332667
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.66978074
62	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.64968285
63	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.63009850
64	HTLV-I infection_Homo sapiens_hsa05166	0.61978604
65	Viral carcinogenesis_Homo sapiens_hsa05203	0.61030003
66	Pancreatic cancer_Homo sapiens_hsa05212	0.58934459
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58297309
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56327351
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52156060
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.48885742
71	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47279588
72	Herpes simplex infection_Homo sapiens_hsa05168	0.46493993
73	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.45593971
74	Adherens junction_Homo sapiens_hsa04520	0.43996610
75	Viral myocarditis_Homo sapiens_hsa05416	0.43628376
76	Proteoglycans in cancer_Homo sapiens_hsa05205	0.41981252
77	MicroRNAs in cancer_Homo sapiens_hsa05206	0.41210995
78	Salmonella infection_Homo sapiens_hsa05132	0.40454316
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.39515820
80	Other glycan degradation_Homo sapiens_hsa00511	0.38521596
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37919077
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.36954769
83	Metabolic pathways_Homo sapiens_hsa01100	0.36771989
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35772578
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.33148465
86	Focal adhesion_Homo sapiens_hsa04510	0.33020947
87	Hepatitis B_Homo sapiens_hsa05161	0.32405380
88	Oocyte meiosis_Homo sapiens_hsa04114	0.31263665
89	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30217280
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.29469105
91	Non-small cell lung cancer_Homo sapiens_hsa05223	0.28682255
92	Colorectal cancer_Homo sapiens_hsa05210	0.26396664
93	Melanoma_Homo sapiens_hsa05218	0.26225571
94	Endocytosis_Homo sapiens_hsa04144	0.25808191
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24689253
96	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.23821520
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.23591593
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23089389
99	AMPK signaling pathway_Homo sapiens_hsa04152	0.21203754
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.20382589

HMGA1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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