HMGA1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)6.50616131
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.48747258
3peptidyl-proline hydroxylation (GO:0019511)5.66763212
4protein hydroxylation (GO:0018126)5.24277866
5C21-steroid hormone biosynthetic process (GO:0006700)4.72791690
6cellular response to zinc ion (GO:0071294)4.44831572
7cranial suture morphogenesis (GO:0060363)4.21121541
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.20532618
94-hydroxyproline metabolic process (GO:0019471)4.14718820
10regulation of chromatin binding (GO:0035561)4.08218795
11endosome to melanosome transport (GO:0035646)4.02666912
12endosome to pigment granule transport (GO:0043485)4.02666912
13nucleotide-sugar biosynthetic process (GO:0009226)3.99299172
14negative regulation of fatty acid biosynthetic process (GO:0045717)3.90725148
15regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.75123007
16histone H4 deacetylation (GO:0070933)3.73497820
17negative regulation of myotube differentiation (GO:0010832)3.71398654
18regulation of somitogenesis (GO:0014807)3.69271954
19UDP-N-acetylglucosamine metabolic process (GO:0006047)3.66519412
20embryonic skeletal joint morphogenesis (GO:0060272)3.63143958
21cholesterol biosynthetic process (GO:0006695)3.55762127
22mRNA cleavage (GO:0006379)3.54451988
23pre-miRNA processing (GO:0031054)3.53793177
24L-ascorbic acid metabolic process (GO:0019852)3.53121328
25keratinocyte proliferation (GO:0043616)3.52764242
26regulation of podosome assembly (GO:0071801)3.51791417
27regulation of female gonad development (GO:2000194)3.50598502
28COPII vesicle coating (GO:0048208)3.48481150
29negative regulation of vascular permeability (GO:0043116)3.46736369
30corticosteroid receptor signaling pathway (GO:0031958)3.46267742
31xenobiotic catabolic process (GO:0042178)3.45039931
32negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.34429251
33cellular response to glucose starvation (GO:0042149)3.31855244
34Golgi transport vesicle coating (GO:0048200)3.27427058
35COPI coating of Golgi vesicle (GO:0048205)3.27427058
36hyaluronan catabolic process (GO:0030214)3.26826396
37protein maturation by protein folding (GO:0022417)3.19447907
38short-term memory (GO:0007614)3.19092883
39glucocorticoid receptor signaling pathway (GO:0042921)3.18757736
40heterochromatin organization (GO:0070828)3.18666041
41modification by host of symbiont morphology or physiology (GO:0051851)3.15472668
42negative regulation of DNA-templated transcription, elongation (GO:0032785)3.14600629
43GDP-mannose metabolic process (GO:0019673)3.14323726
44iron ion import (GO:0097286)3.11222151
45intra-S DNA damage checkpoint (GO:0031573)3.11091209
46regulation of translational termination (GO:0006449)3.08063995
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06870930
48negative regulation of translation, ncRNA-mediated (GO:0040033)3.06870930
49regulation of translation, ncRNA-mediated (GO:0045974)3.06870930
50positive regulation of steroid hormone secretion (GO:2000833)3.05336221
51eyelid development in camera-type eye (GO:0061029)3.05139479
52DNA integration (GO:0015074)3.05029007
53modulation by host of viral transcription (GO:0043921)3.04234794
54modulation by host of symbiont transcription (GO:0052472)3.04234794
55cellular response to cadmium ion (GO:0071276)3.03603601
56mannosylation (GO:0097502)3.01426277
57telomere maintenance via telomerase (GO:0007004)3.00402044
58progesterone metabolic process (GO:0042448)2.99319626
59base-excision repair, AP site formation (GO:0006285)2.97073968
60interaction with symbiont (GO:0051702)2.96369167
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.95770939
62lactate metabolic process (GO:0006089)2.91836724
63growth hormone secretion (GO:0030252)2.90930135
64histone H3-K36 demethylation (GO:0070544)2.89046158
65sterol biosynthetic process (GO:0016126)2.88404486
66DNA damage response, signal transduction resulting in transcription (GO:0042772)2.88272225
67activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.82816563
68histone H3 deacetylation (GO:0070932)2.80096390
69positive regulation of cell size (GO:0045793)2.79071256
70cell migration involved in sprouting angiogenesis (GO:0002042)2.77253621
71lung vasculature development (GO:0060426)2.74727789
72positive regulation of protein kinase C signaling (GO:0090037)2.73627439
73ER-nucleus signaling pathway (GO:0006984)2.72809031
74fibroblast migration (GO:0010761)2.71898350
75modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.69851132
76preassembly of GPI anchor in ER membrane (GO:0016254)2.69560599
77maintenance of protein localization in organelle (GO:0072595)2.67940046
78negative regulation of gene silencing (GO:0060969)2.67479502
79GPI anchor biosynthetic process (GO:0006506)2.66758602
80myoblast differentiation (GO:0045445)2.66210148
81positive regulation of nuclease activity (GO:0032075)2.66072390
82endoplasmic reticulum unfolded protein response (GO:0030968)2.65168703
83monoubiquitinated protein deubiquitination (GO:0035520)2.61727373
84branching involved in prostate gland morphogenesis (GO:0060442)2.59750414
85regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.58910287
86positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.58910287
87mitotic chromosome condensation (GO:0007076)2.57158237
88pyrimidine nucleotide catabolic process (GO:0006244)2.56746569
89ketone biosynthetic process (GO:0042181)2.54405847
90dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53336740
91regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.49656078
92positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.49656078
93RNA-dependent DNA replication (GO:0006278)2.47331812
94cellular response to topologically incorrect protein (GO:0035967)2.46264059
95negative regulation of smooth muscle cell migration (GO:0014912)2.45644278
96cellular response to unfolded protein (GO:0034620)2.45591006
97regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.45184305
98C-terminal protein lipidation (GO:0006501)2.44939678
99positive regulation by host of viral transcription (GO:0043923)2.44449007
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44284059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HIF1A_21447827_ChIP-Seq_MCF-7_Human4.28322023
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.77270330
3E2F7_22180533_ChIP-Seq_HELA_Human2.67216373
4MYC_22102868_ChIP-Seq_BL_Human2.66467120
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.48651152
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.40337647
7VDR_21846776_ChIP-Seq_THP-1_Human2.35727340
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.30341748
9CIITA_25753668_ChIP-Seq_RAJI_Human2.24744113
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23570327
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16880130
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15905652
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15905652
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15905652
15YY1_21170310_ChIP-Seq_MESCs_Mouse2.09703601
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05773179
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.88174880
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87006581
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77345165
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74316333
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73726029
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72955211
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72134279
24GABP_19822575_ChIP-Seq_HepG2_Human1.69804731
25ATF3_27146783_Chip-Seq_COLON_Human1.65079534
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63560308
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63320709
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62827905
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58588649
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57623112
31MAF_26560356_Chip-Seq_TH1_Human1.53549378
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51618197
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51324467
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48789963
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48462436
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46930152
37RACK7_27058665_Chip-Seq_MCF-7_Human1.44677413
38KDM5A_27292631_Chip-Seq_BREAST_Human1.43817810
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42704971
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42507687
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38284591
42MAF_26560356_Chip-Seq_TH2_Human1.37300461
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.35078003
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33172964
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.33145496
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32738690
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31707443
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.30308821
49VDR_24763502_ChIP-Seq_THP-1_Human1.28341181
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26674354
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26292083
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25381704
53TFEB_21752829_ChIP-Seq_HELA_Human1.24997355
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24525392
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24179993
56LXR_22292898_ChIP-Seq_THP-1_Human1.23326685
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23209357
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22088893
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20980683
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20914764
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19207907
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.18734759
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18651033
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18494951
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17474993
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16493570
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.16477041
68XRN2_22483619_ChIP-Seq_HELA_Human1.16132100
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15362612
70EGR1_19032775_ChIP-ChIP_M12_Human1.14301261
71UTX_26944678_Chip-Seq_JUKART_Human1.13892079
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12851195
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12313727
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.12018826
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.11028323
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10468162
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09145808
78CHD1_26751641_Chip-Seq_LNCaP_Human1.08293751
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.07927409
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07584260
81DCP1A_22483619_ChIP-Seq_HELA_Human1.06974820
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06973721
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05837480
84NCOR1_26117541_ChIP-Seq_K562_Human1.03169445
85ELK1_19687146_ChIP-ChIP_HELA_Human0.99465438
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99145854
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99124280
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98139555
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97682661
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97219068
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96329892
92BCL6_27268052_Chip-Seq_Bcells_Human0.95842023
93CTCF_21964334_Chip-Seq_Bcells_Human0.95827425
94TTF2_22483619_ChIP-Seq_HELA_Human0.95448694
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94731742
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.94455212
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.94371168
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94127757
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93916409
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93119205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence3.53672843
2MP0003950_abnormal_plasma_membrane3.40963337
3MP0003315_abnormal_perineum_morphology3.33274560
4MP0008260_abnormal_autophagy3.14215273
5MP0008789_abnormal_olfactory_epithelium2.84896145
6MP0008961_abnormal_basal_metabolism2.73912609
7MP0010234_abnormal_vibrissa_follicle2.63946010
8MP0002166_altered_tumor_susceptibility2.55825775
9MP0010030_abnormal_orbit_morphology2.55457666
10MP0005394_taste/olfaction_phenotype2.41552562
11MP0005499_abnormal_olfactory_system2.41552562
12MP0003941_abnormal_skin_development2.38460364
13MP0004272_abnormal_basement_membrane2.31057934
14MP0003656_abnormal_erythrocyte_physiolo2.27544190
15MP0003693_abnormal_embryo_hatching2.09431749
16MP0006054_spinal_hemorrhage2.09366074
17MP0003279_aneurysm2.00285162
18MP0005645_abnormal_hypothalamus_physiol2.00065327
19MP0003172_abnormal_lysosome_physiology1.99735019
20MP0000537_abnormal_urethra_morphology1.97732834
21MP0005410_abnormal_fertilization1.92354674
22MP0008438_abnormal_cutaneous_collagen1.83283045
23MP0005076_abnormal_cell_differentiation1.76356079
24MP0006292_abnormal_olfactory_placode1.71280138
25MP0006072_abnormal_retinal_apoptosis1.71007032
26MP0003077_abnormal_cell_cycle1.67413652
27MP0003091_abnormal_cell_migration1.66330065
28MP0003221_abnormal_cardiomyocyte_apopto1.64780639
29MP0010094_abnormal_chromosome_stability1.63775113
30MP0009697_abnormal_copulation1.63587201
31MP0008058_abnormal_DNA_repair1.60858921
32MP0005647_abnormal_sex_gland1.60245778
33MP0002160_abnormal_reproductive_system1.59845158
34MP0004043_abnormal_pH_regulation1.59736701
35MP0003111_abnormal_nucleus_morphology1.50962412
36MP0004233_abnormal_muscle_weight1.49451839
37MP0003786_premature_aging1.46495225
38MP0002006_tumorigenesis1.41999074
39MP0000358_abnormal_cell_content/1.37447129
40MP0002009_preneoplasia1.32029538
41MP0001545_abnormal_hematopoietic_system1.27933731
42MP0005397_hematopoietic_system_phenotyp1.27933731
43MP0005083_abnormal_biliary_tract1.27362478
44MP0008932_abnormal_embryonic_tissue1.23562806
45MP0003183_abnormal_peptide_metabolism1.18824803
46MP0003755_abnormal_palate_morphology1.17397415
47MP0001270_distended_abdomen1.17059084
48MP0001119_abnormal_female_reproductive1.11686372
49MP0000678_abnormal_parathyroid_gland1.11651717
50MP0000733_abnormal_muscle_development1.11288439
51MP0003191_abnormal_cellular_cholesterol1.10498713
52MP0003195_calcinosis1.08863279
53MP0001727_abnormal_embryo_implantation1.08513163
54MP0000350_abnormal_cell_proliferation1.06213811
55MP0006035_abnormal_mitochondrial_morpho1.03808549
56MP0002254_reproductive_system_inflammat0.96743385
57MP0005389_reproductive_system_phenotype0.96091482
58MP0002111_abnormal_tail_morphology0.95232585
59MP0003942_abnormal_urinary_system0.92561406
60MP0005310_abnormal_salivary_gland0.92216584
61MP0001853_heart_inflammation0.92156868
62MP0002735_abnormal_chemical_nociception0.90796750
63MP0002877_abnormal_melanocyte_morpholog0.87769347
64MP0004742_abnormal_vestibular_system0.87296875
65MP0004510_myositis0.86919566
66MP0005377_hearing/vestibular/ear_phenot0.84677817
67MP0003878_abnormal_ear_physiology0.84677817
68MP0004147_increased_porphyrin_level0.84199976
69MP0005621_abnormal_cell_physiology0.82109763
70MP0003115_abnormal_respiratory_system0.79717646
71MP0005384_cellular_phenotype0.79066566
72MP0005023_abnormal_wound_healing0.78971241
73MP0001529_abnormal_vocalization0.77973671
74MP0000163_abnormal_cartilage_morphology0.77701005
75MP0009278_abnormal_bone_marrow0.76391349
76MP0002653_abnormal_ependyma_morphology0.76302634
77MP0000313_abnormal_cell_death0.75657743
78MP0002295_abnormal_pulmonary_circulatio0.74610025
79MP0009333_abnormal_splenocyte_physiolog0.73960496
80MP0005187_abnormal_penis_morphology0.73754645
81MP0003699_abnormal_female_reproductive0.71968268
82MP0005501_abnormal_skin_physiology0.70526143
83MP0000432_abnormal_head_morphology0.70051502
84MP0000613_abnormal_salivary_gland0.69944401
85MP0002405_respiratory_system_inflammati0.69014119
86MP0002722_abnormal_immune_system0.68830366
87MP0000653_abnormal_sex_gland0.68716934
88MP0008004_abnormal_stomach_pH0.68233403
89MP0010678_abnormal_skin_adnexa0.67416955
90MP0003632_abnormal_nervous_system0.67271172
91MP0003186_abnormal_redox_activity0.66908857
92MP0005167_abnormal_blood-brain_barrier0.66443296
93MP0003984_embryonic_growth_retardation0.66128587
94MP0005584_abnormal_enzyme/coenzyme_acti0.66118651
95MP0010307_abnormal_tumor_latency0.64691777
96MP0002080_prenatal_lethality0.64421166
97MP0002396_abnormal_hematopoietic_system0.63638863
98MP0002084_abnormal_developmental_patter0.62409560
99MP0008007_abnormal_cellular_replicative0.61483616
100MP0003385_abnormal_body_wall0.61377683

Predicted human phenotypes

RankGene SetZ-score
1Natal tooth (HP:0000695)4.58838788
2Cervical subluxation (HP:0003308)4.04784048
3Diplopia (HP:0000651)4.03085568
4Abnormality of binocular vision (HP:0011514)4.03085568
5Long palpebral fissure (HP:0000637)3.60826146
6Increased serum ferritin (HP:0003281)3.43784099
7Progressive muscle weakness (HP:0003323)3.36913051
8Increased serum pyruvate (HP:0003542)3.35518002
9Trigonocephaly (HP:0000243)3.23685026
10Neonatal short-limb short stature (HP:0008921)3.20306527
11Paralysis (HP:0003470)3.07058337
12Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.98810747
13Recurrent sinusitis (HP:0011108)2.91969245
14Abnormality of glycolysis (HP:0004366)2.87204966
15Increased cerebral lipofuscin (HP:0011813)2.87038079
16Increased neuronal autofluorescent lipopigment (HP:0002074)2.83913962
17Male infertility (HP:0003251)2.72850744
18Long eyelashes (HP:0000527)2.71643992
19Reticulocytosis (HP:0001923)2.70935558
20Urethral obstruction (HP:0000796)2.66129304
21Sparse lateral eyebrow (HP:0005338)2.57941236
22High anterior hairline (HP:0009890)2.49932968
23Abnormality of the pons (HP:0007361)2.44667570
24Spinal cord lesions (HP:0100561)2.43360939
25Syringomyelia (HP:0003396)2.43360939
26Microvesicular hepatic steatosis (HP:0001414)2.41086411
27Ectopic kidney (HP:0000086)2.41038122
28Cupped ribs (HP:0000887)2.40049576
29Short 5th finger (HP:0009237)2.39332775
30Exercise-induced muscle cramps (HP:0003710)2.38633538
31Short humerus (HP:0005792)2.38083184
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.36348896
33Depressed nasal tip (HP:0000437)2.35024102
34Hyperglycinemia (HP:0002154)2.30724056
35Abnormality of the alveolar ridges (HP:0006477)2.30706124
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29270909
37Septo-optic dysplasia (HP:0100842)2.27091981
38Spastic paraplegia (HP:0001258)2.26833336
39Genetic anticipation (HP:0003743)2.26623168
40Aplasia/hypoplasia of the humerus (HP:0006507)2.24949565
41Lip pit (HP:0100267)2.21774647
42Flat acetabular roof (HP:0003180)2.20413764
43Abnormal biliary tract physiology (HP:0012439)2.19723255
44Bile duct proliferation (HP:0001408)2.19723255
45Abnormality of the columella (HP:0009929)2.17657290
46Confusion (HP:0001289)2.14585248
47Advanced eruption of teeth (HP:0006288)2.14411206
48Abnormality of iron homeostasis (HP:0011031)2.13566421
49Hypercholesterolemia (HP:0003124)2.03185126
50Homocystinuria (HP:0002156)2.00038809
51Abnormality of homocysteine metabolism (HP:0010919)2.00038809
52Hemorrhage of the eye (HP:0011885)1.99460493
53Postnatal microcephaly (HP:0005484)1.98791849
54Autoimmune thrombocytopenia (HP:0001973)1.96791413
55Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96251105
56Asplenia (HP:0001746)1.95234217
57Poor head control (HP:0002421)1.94990388
58Abnormality of transition element cation homeostasis (HP:0011030)1.94229371
59Facial cleft (HP:0002006)1.93577806
60Thoracic kyphosis (HP:0002942)1.92311269
61Hyperacusis (HP:0010780)1.91569231
62Mitral stenosis (HP:0001718)1.91196535
63Abnormality of glycolipid metabolism (HP:0010969)1.88335243
64Abnormality of liposaccharide metabolism (HP:0010968)1.88335243
65Abnormality of glycosphingolipid metabolism (HP:0004343)1.88335243
66Capillary hemangiomas (HP:0005306)1.87668716
67Vacuolated lymphocytes (HP:0001922)1.87295187
68Mildly elevated creatine phosphokinase (HP:0008180)1.85088470
69Abnormality of carpal bone ossification (HP:0006257)1.84782443
70Diminished motivation (HP:0000745)1.84612475
71Broad thumb (HP:0011304)1.82762267
72Paraplegia (HP:0010550)1.81651968
73Gonadotropin excess (HP:0000837)1.80605455
74Hypoplasia of the pons (HP:0012110)1.80290167
75Reduced antithrombin III activity (HP:0001976)1.80272078
76Abnormality of the thoracic spine (HP:0100711)1.79804417
77Back pain (HP:0003418)1.79328816
78Pancreatic islet-cell hyperplasia (HP:0004510)1.77625175
79Diastasis recti (HP:0001540)1.76332426
80Hepatocellular carcinoma (HP:0001402)1.76076148
81Abnormality of the lower motor neuron (HP:0002366)1.75899561
82Flared iliac wings (HP:0002869)1.75445120
83Supernumerary spleens (HP:0009799)1.74654583
84Dyschromatopsia (HP:0007641)1.71747772
85Interstitial pulmonary disease (HP:0006530)1.71621008
86Hypoplasia of the odontoid process (HP:0003311)1.71333496
87Upper limb muscle weakness (HP:0003484)1.71061322
88Abnormality of reticulocytes (HP:0004312)1.70918140
89Morphological abnormality of the middle ear (HP:0008609)1.70269071
90Abnormal ossification of hand bones (HP:0005921)1.69939659
91Broad alveolar ridges (HP:0000187)1.69047142
92Abnormal number of erythroid precursors (HP:0012131)1.68811452
93Abnormality of the nasal septum (HP:0000419)1.66865174
94Arthropathy (HP:0003040)1.65190919
95Recurrent otitis media (HP:0000403)1.64246460
96Retinal dysplasia (HP:0007973)1.63377798
97Mask-like facies (HP:0000298)1.63182549
98Abnormality of abdominal situs (HP:0011620)1.63122145
99Abdominal situs inversus (HP:0003363)1.63122145
100Dyskinesia (HP:0100660)1.62523519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.20096910
2MAP4K23.92090058
3DDR23.80886952
4BRSK23.25649058
5TRIM283.13383338
6MAP3K132.85285271
7ICK2.82632878
8SRPK12.82471397
9MAP3K72.54507365
10SMG12.37017350
11CAMK1D2.26506091
12MAP3K32.25450109
13CSNK1A1L2.15233412
14EPHA22.09803254
15CDC71.91119586
16MAPK111.70801699
17CSNK1G31.68593117
18CAMK1G1.49775624
19PAK41.34010131
20PKN21.31562802
21BRSK11.29982250
22VRK21.28453723
23MST1R1.28052017
24WEE11.27846439
25IRAK31.27316228
26CDK191.26842161
27RIPK41.25902440
28CDK61.23302704
29MOS1.21652798
30WNK41.19581497
31BMPR21.15670936
32SIK31.12066316
33MAP3K141.09726943
34ARAF1.09546463
35CCNB11.06996574
36CSNK1G11.04868145
37FLT30.97865950
38MTOR0.95838644
39CSNK1G20.94300391
40CDK40.90122522
41ERN10.89063362
42LMTK20.87063677
43CHEK10.86989355
44VRK10.86942305
45BRD40.85510375
46SIK10.84023361
47PRKAA10.82240951
48FGFR10.82227123
49PKN10.82071631
50NEK90.80636882
51MAP3K110.79754311
52GRK10.78302305
53TRIB30.75028788
54ATR0.73290438
55DYRK1B0.72123207
56MATK0.70929861
57BTK0.68525265
58FES0.67849556
59CDK70.65706942
60RPS6KA40.63985417
61ERBB40.61997504
62NEK20.57594492
63EPHA40.55697405
64STK100.55609336
65PIM20.53578972
66RPS6KC10.53182868
67RPS6KL10.53182868
68KSR20.52516227
69TYK20.51907244
70DAPK10.50623170
71PLK10.49943517
72TBK10.49557504
73PRKD20.49006575
74GSK3A0.48146048
75ATM0.47884909
76HCK0.47833506
77MARK20.47657795
78SIK20.47036068
79PRKAA20.46771464
80RPS6KA60.43392915
81CDC42BPA0.43049290
82CSNK1A10.42705156
83CDK90.41241071
84DYRK30.40406276
85IKBKB0.39808623
86MAP3K90.39128748
87SCYL20.38887372
88MAP2K30.38476296
89ZAK0.37893231
90CHEK20.37195602
91IRAK40.36992368
92KIT0.35976373
93AKT10.35515057
94CDK20.35150727
95TEC0.34632824
96TLK10.34534498
97PRKD10.33132418
98CHUK0.33028455
99DYRK1A0.32430005
100ERBB30.32387066

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.73407653
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.33483402
3Base excision repair_Homo sapiens_hsa034103.19512601
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.16101691
5Steroid biosynthesis_Homo sapiens_hsa001002.59636815
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.56583299
7Non-homologous end-joining_Homo sapiens_hsa034502.48735188
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.39313745
9DNA replication_Homo sapiens_hsa030302.12374890
10Lysine degradation_Homo sapiens_hsa003102.09991912
11Other glycan degradation_Homo sapiens_hsa005112.04691378
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.83367166
13Prostate cancer_Homo sapiens_hsa052151.76326085
14Fructose and mannose metabolism_Homo sapiens_hsa000511.74802594
15Notch signaling pathway_Homo sapiens_hsa043301.72016963
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61913928
17Spliceosome_Homo sapiens_hsa030401.56576996
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49534757
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46644460
20Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41970208
21Homologous recombination_Homo sapiens_hsa034401.35967911
22Bladder cancer_Homo sapiens_hsa052191.31451303
23HIF-1 signaling pathway_Homo sapiens_hsa040661.27288161
24Biosynthesis of amino acids_Homo sapiens_hsa012301.24728810
25Chronic myeloid leukemia_Homo sapiens_hsa052201.21335096
26Thyroid cancer_Homo sapiens_hsa052161.15353818
27Herpes simplex infection_Homo sapiens_hsa051681.14287569
28Mineral absorption_Homo sapiens_hsa049781.12815644
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10974785
30Shigellosis_Homo sapiens_hsa051311.09426272
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.06742406
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06166983
33N-Glycan biosynthesis_Homo sapiens_hsa005101.04313910
34MicroRNAs in cancer_Homo sapiens_hsa052061.03856199
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01445171
36Hepatitis B_Homo sapiens_hsa051611.00885058
37Pyrimidine metabolism_Homo sapiens_hsa002401.00459687
38Galactose metabolism_Homo sapiens_hsa000520.96749981
39Glutathione metabolism_Homo sapiens_hsa004800.94088570
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93962985
41Viral carcinogenesis_Homo sapiens_hsa052030.92609171
42RNA transport_Homo sapiens_hsa030130.92569017
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90007337
44Insulin resistance_Homo sapiens_hsa049310.89424505
45Cell cycle_Homo sapiens_hsa041100.88665286
46RNA polymerase_Homo sapiens_hsa030200.87869075
47Epstein-Barr virus infection_Homo sapiens_hsa051690.86222196
48Caffeine metabolism_Homo sapiens_hsa002320.84693599
49Small cell lung cancer_Homo sapiens_hsa052220.83815838
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83273649
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81215523
52Acute myeloid leukemia_Homo sapiens_hsa052210.80131410
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75769917
54B cell receptor signaling pathway_Homo sapiens_hsa046620.73403705
55mRNA surveillance pathway_Homo sapiens_hsa030150.71352414
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70457924
57Influenza A_Homo sapiens_hsa051640.65148551
58Circadian rhythm_Homo sapiens_hsa047100.65052568
59Adherens junction_Homo sapiens_hsa045200.64259069
60Non-small cell lung cancer_Homo sapiens_hsa052230.62379115
61HTLV-I infection_Homo sapiens_hsa051660.62006907
62Lysosome_Homo sapiens_hsa041420.61016432
63Basal cell carcinoma_Homo sapiens_hsa052170.59884112
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59542465
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56474089
66Fanconi anemia pathway_Homo sapiens_hsa034600.56420917
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.56233777
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54213478
69AMPK signaling pathway_Homo sapiens_hsa041520.53802039
70Pancreatic cancer_Homo sapiens_hsa052120.53236477
71TNF signaling pathway_Homo sapiens_hsa046680.53112042
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52984525
73Inositol phosphate metabolism_Homo sapiens_hsa005620.52912808
74Renal cell carcinoma_Homo sapiens_hsa052110.52594098
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52527367
76Legionellosis_Homo sapiens_hsa051340.50031517
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50023662
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.49589547
79p53 signaling pathway_Homo sapiens_hsa041150.49170483
80Systemic lupus erythematosus_Homo sapiens_hsa053220.49084782
81One carbon pool by folate_Homo sapiens_hsa006700.46582519
82Endometrial cancer_Homo sapiens_hsa052130.45944172
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.45730365
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44031734
85Arachidonic acid metabolism_Homo sapiens_hsa005900.43800430
86Measles_Homo sapiens_hsa051620.42946658
87Selenocompound metabolism_Homo sapiens_hsa004500.42858564
88Apoptosis_Homo sapiens_hsa042100.42421919
89Viral myocarditis_Homo sapiens_hsa054160.39288575
90Hematopoietic cell lineage_Homo sapiens_hsa046400.38592728
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.38080044
92Renin-angiotensin system_Homo sapiens_hsa046140.38010269
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37353505
94Linoleic acid metabolism_Homo sapiens_hsa005910.35594872
95Protein export_Homo sapiens_hsa030600.35374540
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34666202
97Asthma_Homo sapiens_hsa053100.34154094
98Fat digestion and absorption_Homo sapiens_hsa049750.33842013
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33596679
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33371800

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