ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female receptivity (GO:0045924)	7.31303032
2	female mating behavior (GO:0060180)	7.01977934
3	regulation of gonadotropin secretion (GO:0032276)	5.36960097
4	aggressive behavior (GO:0002118)	5.36435194
5	maternal behavior (GO:0042711)	4.21779039
6	lipopolysaccharide biosynthetic process (GO:0009103)	4.16342554
7	proline biosynthetic process (GO:0006561)	4.14597519
8	ketone body metabolic process (GO:1902224)	4.13343752
9	cellular ketone body metabolic process (GO:0046950)	4.08315456
10	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	4.06054536
11	proteasome assembly (GO:0043248)	4.02104068
12	positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081	4.00137018
13	positive regulation of macrophage cytokine production (GO:0060907)	3.95073384
14	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.95027293
15	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.92478134
16	transcription from mitochondrial promoter (GO:0006390)	3.80808107
17	DNA deamination (GO:0045006)	3.76804565
18	positive regulation of prostaglandin secretion (GO:0032308)	3.76783539
19	parental behavior (GO:0060746)	3.75701009
20	multicellular organismal reproductive behavior (GO:0033057)	3.73437884
21	T-helper 1 type immune response (GO:0042088)	3.70472764
22	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.68999289
23	respiratory chain complex IV assembly (GO:0008535)	3.67776406
24	regulation of transmission of nerve impulse (GO:0051969)	3.65974244
25	protein localization to cilium (GO:0061512)	3.61951724
26	regulation of B cell apoptotic process (GO:0002902)	3.61401501
27	chromatin assembly (GO:0031497)	3.60338794
28	cellular response to interferon-beta (GO:0035458)	3.60166046
29	hyperosmotic salinity response (GO:0042538)	3.47830504
30	cholesterol biosynthetic process (GO:0006695)	3.45411349
31	negative regulation of phagocytosis (GO:0050765)	3.44692972
32	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.36925935
33	metallo-sulfur cluster assembly (GO:0031163)	3.34157606
34	iron-sulfur cluster assembly (GO:0016226)	3.34157606
35	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.25563305
36	negative regulation of cell aging (GO:0090344)	3.25439501
37	GTP biosynthetic process (GO:0006183)	3.21176472
38	mitotic nuclear envelope reassembly (GO:0007084)	3.20604172
39	nuclear envelope reassembly (GO:0031468)	3.20604172
40	lipopolysaccharide metabolic process (GO:0008653)	3.19064348
41	response to interferon-beta (GO:0035456)	3.17652365
42	regulation of interferon-gamma biosynthetic process (GO:0045072)	3.16629537
43	sterol biosynthetic process (GO:0016126)	3.16029841
44	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.13570519
45	protein ADP-ribosylation (GO:0006471)	3.12254117
46	UTP biosynthetic process (GO:0006228)	3.09970552
47	isoprenoid biosynthetic process (GO:0008299)	3.08599092
48	primitive streak formation (GO:0090009)	3.06515683
49	protein complex biogenesis (GO:0070271)	3.06097913
50	hair cell differentiation (GO:0035315)	3.05970250
51	UTP metabolic process (GO:0046051)	3.05855933
52	mitochondrial RNA metabolic process (GO:0000959)	3.05647609
53	grooming behavior (GO:0007625)	3.05375493
54	keratinocyte development (GO:0003334)	2.96831071
55	regulation of prostaglandin secretion (GO:0032306)	2.96294204
56	regulation of mitochondrial translation (GO:0070129)	2.96060379
57	meiotic chromosome segregation (GO:0045132)	2.95356426
58	CTP metabolic process (GO:0046036)	2.95081864
59	CTP biosynthetic process (GO:0006241)	2.95081864
60	positive regulation of interleukin-8 secretion (GO:2000484)	2.94611828
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93339741
62	regulation of metalloenzyme activity (GO:0048552)	2.93078882
63	negative regulation of neurological system process (GO:0031645)	2.92611838
64	cytochrome complex assembly (GO:0017004)	2.91838536
65	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.91737107
66	positive regulation of amino acid transport (GO:0051957)	2.89549071
67	DNA double-strand break processing (GO:0000729)	2.89497813
68	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.89422970
69	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.89366896
70	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.88438400
71	negative regulation of B cell apoptotic process (GO:0002903)	2.87990843
72	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.86539846
73	DNA synthesis involved in DNA repair (GO:0000731)	2.85704048
74	estrogen biosynthetic process (GO:0006703)	2.83326871
75	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.80394175
76	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.78865339
77	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78733825
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78733825
79	NADH dehydrogenase complex assembly (GO:0010257)	2.78733825
80	proline metabolic process (GO:0006560)	2.77271959
81	regulation of centriole replication (GO:0046599)	2.76847927
82	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.76416416
83	branched-chain amino acid catabolic process (GO:0009083)	2.74820900
84	metaphase plate congression (GO:0051310)	2.72114315
85	nucleoside transmembrane transport (GO:1901642)	2.71386431
86	melanin biosynthetic process (GO:0042438)	2.69921527
87	melanosome transport (GO:0032402)	2.65207530
88	tricarboxylic acid metabolic process (GO:0072350)	2.64433979
89	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.63195981
90	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.62086594
91	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.62086594
92	regulation of antigen processing and presentation (GO:0002577)	2.58207842
93	regulation of macrophage cytokine production (GO:0010935)	2.57854735
94	positive regulation of amine transport (GO:0051954)	2.57813174
95	regulation of T cell receptor signaling pathway (GO:0050856)	2.56043263
96	regulation of uterine smooth muscle contraction (GO:0070472)	2.53475286
97	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.50981387
98	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.47844777
99	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.47570096
100	glutamine metabolic process (GO:0006541)	2.47053852

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.44349651
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.41807225
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.31155335
4	GATA1_22025678_ChIP-Seq_K562_Human	3.14821674
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.86015007
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.78509280
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.71768757
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64870629
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.53853706
10	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.53580283
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.44370596
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38050518
13	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.37491060
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.36584299
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.34111544
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.32935407
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25894631
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.25664126
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.24621215
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.20908416
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.16284983
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.14966835
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09003280
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.08250880
25	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.99228004
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.98308956
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.93585839
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.90256743
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89609818
30	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.89481382
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.87639429
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87397412
33	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.82879976
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.80581908
35	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.70024917
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.69901983
37	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.65317586
38	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.65133802
39	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.64067893
40	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.61651983
41	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.61312173
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.59434254
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.58341149
44	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.55239658
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.55206907
46	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.50633178
47	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.46207615
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.45809652
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.43427056
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42399045
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.42383722
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.41338882
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40661838
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39472171
55	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.35730532
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.35729221
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34921944
58	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.31038685
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.24531322
60	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.23396470
61	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.21554955
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.20937976
63	BCOR_27268052_Chip-Seq_Bcells_Human	1.19655409
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18362169
65	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16958399
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.15355548
67	ZNF274_21170338_ChIP-Seq_K562_Hela	1.12186875
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11654052
69	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.11464484
70	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.11020651
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08212572
72	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05997536
73	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.05767036
74	TFEB_21752829_ChIP-Seq_HELA_Human	1.04792717
75	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.03775270
76	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03694797
77	BCL6_27268052_Chip-Seq_Bcells_Human	1.03462986
78	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.03097329
79	E2F7_22180533_ChIP-Seq_HELA_Human	1.00049153
80	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.99609162
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99546585
82	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.98944073
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98337243
84	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.94888421
85	P300_27268052_Chip-Seq_Bcells_Human	0.94858732
86	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.93951888
87	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93845924
88	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.91341934
89	ZNF263_19887448_ChIP-Seq_K562_Human	0.91275804
90	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.90744149
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89592136
92	MYC_22102868_ChIP-Seq_BL_Human	0.89117308
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.89013201
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86886484
95	PHF8_20622854_ChIP-Seq_HELA_Human	0.86591616
96	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.86180085
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.85935028
98	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.85770039
99	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.84802000
100	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.84446428

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	5.43928841
2	MP0010234_abnormal_vibrissa_follicle	5.39330637
3	MP0005645_abnormal_hypothalamus_physiol	5.25950450
4	MP0002163_abnormal_gland_morphology	5.00594660
5	MP0003136_yellow_coat_color	4.29069626
6	MP0000685_abnormal_immune_system	4.27270455
7	MP0005379_endocrine/exocrine_gland_phen	3.35167451
8	MP0002254_reproductive_system_inflammat	3.26696515
9	MP0002132_abnormal_respiratory_system	2.75020417
10	MP0006036_abnormal_mitochondrial_physio	2.49315688
11	MP0010094_abnormal_chromosome_stability	2.42289869
12	MP0005084_abnormal_gallbladder_morpholo	2.34695859
13	MP0008058_abnormal_DNA_repair	2.20227354
14	MP0009046_muscle_twitch	2.02905971
15	MP0001790_abnormal_immune_system	1.67409883
16	MP0005387_immune_system_phenotype	1.67409883
17	MP0003806_abnormal_nucleotide_metabolis	1.63071509
18	MP0005623_abnormal_meninges_morphology	1.62935068
19	MP0000013_abnormal_adipose_tissue	1.62079812
20	MP0002138_abnormal_hepatobiliary_system	1.59832845
21	MP0002837_dystrophic_cardiac_calcinosis	1.51360489
22	MP0010352_gastrointestinal_tract_polyps	1.50046551
23	MP0008875_abnormal_xenobiotic_pharmacok	1.42687924
24	MP0005410_abnormal_fertilization	1.41208789
25	MP0002090_abnormal_vision	1.34767813
26	MP0002938_white_spotting	1.34301836
27	MP0002160_abnormal_reproductive_system	1.32313193
28	MP0003077_abnormal_cell_cycle	1.31529959
29	MP0004381_abnormal_hair_follicle	1.31084811
30	MP0006292_abnormal_olfactory_placode	1.26640403
31	MP0005671_abnormal_response_to	1.25376132
32	MP0005464_abnormal_platelet_physiology	1.21654163
33	MP0003646_muscle_fatigue	1.17142639
34	MP0002277_abnormal_respiratory_mucosa	1.16682843
35	MP0001800_abnormal_humoral_immune	1.16048176
36	MP0006035_abnormal_mitochondrial_morpho	1.14990771
37	MP0003111_abnormal_nucleus_morphology	1.13752680
38	MP0005397_hematopoietic_system_phenotyp	1.12755833
39	MP0001545_abnormal_hematopoietic_system	1.12755833
40	MP0003718_maternal_effect	1.12242115
41	MP0004142_abnormal_muscle_tone	1.10426640
42	MP0001348_abnormal_lacrimal_gland	1.10339224
43	MP0003011_delayed_dark_adaptation	1.09344187
44	MP0000647_abnormal_sebaceous_gland	1.04373765
45	MP0005187_abnormal_penis_morphology	1.03998303
46	MP0002653_abnormal_ependyma_morphology	1.01735723
47	MP0000516_abnormal_urinary_system	1.01450660
48	MP0005367_renal/urinary_system_phenotyp	1.01450660
49	MP0001984_abnormal_olfaction	1.00889860
50	MP0002693_abnormal_pancreas_physiology	0.98725844
51	MP0010155_abnormal_intestine_physiology	0.97787736
52	MP0002148_abnormal_hypersensitivity_rea	0.96469442
53	MP0002282_abnormal_trachea_morphology	0.95586516
54	MP0005220_abnormal_exocrine_pancreas	0.93985164
55	MP0001835_abnormal_antigen_presentation	0.93431196
56	MP0005670_abnormal_white_adipose	0.92398524
57	MP0008775_abnormal_heart_ventricle	0.92108813
58	MP0005000_abnormal_immune_tolerance	0.91627467
59	MP0001851_eye_inflammation	0.89564241
60	MP0000230_abnormal_systemic_arterial	0.89386714
61	MP0002452_abnormal_antigen_presenting	0.85507663
62	MP0001661_extended_life_span	0.84037449
63	MP0008872_abnormal_physiological_respon	0.83910015
64	MP0000689_abnormal_spleen_morphology	0.83703472
65	MP0010030_abnormal_orbit_morphology	0.82847717
66	MP0004043_abnormal_pH_regulation	0.82044716
67	MP0000613_abnormal_salivary_gland	0.81028286
68	MP0002876_abnormal_thyroid_physiology	0.79168237
69	MP0001529_abnormal_vocalization	0.79051653
70	MP0003186_abnormal_redox_activity	0.78902090
71	MP0001727_abnormal_embryo_implantation	0.78127248
72	MP0002723_abnormal_immune_serum	0.77153980
73	MP0005025_abnormal_response_to	0.74210043
74	MP0001944_abnormal_pancreas_morphology	0.74147581
75	MP0001853_heart_inflammation	0.74123196
76	MP0002928_abnormal_bile_duct	0.70321814
77	MP0000681_abnormal_thyroid_gland	0.70092990
78	MP0004885_abnormal_endolymph	0.69925463
79	MP0000358_abnormal_cell_content/	0.68115209
80	MP0005389_reproductive_system_phenotype	0.67928431
81	MP0005075_abnormal_melanosome_morpholog	0.67442232
82	MP0002420_abnormal_adaptive_immunity	0.67275226
83	MP0001819_abnormal_immune_cell	0.67257916
84	MP0001986_abnormal_taste_sensitivity	0.65628745
85	MP0005551_abnormal_eye_electrophysiolog	0.65291229
86	MP0001346_abnormal_lacrimal_gland	0.64954392
87	MP0009763_increased_sensitivity_to	0.64334770
88	MP0002398_abnormal_bone_marrow	0.64296564
89	MP0002019_abnormal_tumor_incidence	0.62360621
90	MP0002722_abnormal_immune_system	0.61719159
91	MP0005310_abnormal_salivary_gland	0.60671802
92	MP0004924_abnormal_behavior	0.58504367
93	MP0005386_behavior/neurological_phenoty	0.58504367
94	MP0001845_abnormal_inflammatory_respons	0.58130732
95	MP0003699_abnormal_female_reproductive	0.57830118
96	MP0005319_abnormal_enzyme/_coenzyme	0.57478041
97	MP0001764_abnormal_homeostasis	0.56095120
98	MP0004957_abnormal_blastocyst_morpholog	0.55478346
99	MP0003191_abnormal_cellular_cholesterol	0.55270884
100	MP0009780_abnormal_chondrocyte_physiolo	0.54645337

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gastrointestinal stroma tumor (HP:0100723)	4.20017024
2	Renal Fanconi syndrome (HP:0001994)	4.02602237
3	Conical tooth (HP:0000698)	3.90491035
4	IgA deficiency (HP:0002720)	3.66837521
5	Recurrent sinusitis (HP:0011108)	3.55060621
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.53907268
7	Brittle hair (HP:0002299)	3.50037575
8	Dry hair (HP:0011359)	3.46160749
9	Hepatocellular necrosis (HP:0001404)	3.40581149
10	Pigmentary retinal degeneration (HP:0001146)	3.32394312
11	Acute necrotizing encephalopathy (HP:0006965)	3.32342966
12	Increased intramyocellular lipid droplets (HP:0012240)	3.30247462
13	Concave nail (HP:0001598)	3.28336309
14	Progressive macrocephaly (HP:0004481)	3.22845938
15	Petechiae (HP:0000967)	3.17521398
16	Congenital stationary night blindness (HP:0007642)	3.17489958
17	Mitochondrial inheritance (HP:0001427)	3.11070033
18	Prolonged neonatal jaundice (HP:0006579)	3.11047157
19	Hypoplasia of the fovea (HP:0007750)	3.02986477
20	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.02986477
21	Acute encephalopathy (HP:0006846)	2.96252137
22	Intrahepatic cholestasis (HP:0001406)	2.93963375
23	Increased CSF lactate (HP:0002490)	2.89262523
24	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.82862142
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.82862142
26	Squamous cell carcinoma (HP:0002860)	2.80664982
27	Onycholysis (HP:0001806)	2.80579766
28	Hepatic necrosis (HP:0002605)	2.80550251
29	IgG deficiency (HP:0004315)	2.79329480
30	Respiratory difficulties (HP:0002880)	2.77956388
31	Increased muscle lipid content (HP:0009058)	2.76940804
32	Decreased central vision (HP:0007663)	2.71583463
33	Increased hepatocellular lipid droplets (HP:0006565)	2.69307325
34	Agammaglobulinemia (HP:0004432)	2.59510975
35	Conjunctival hamartoma (HP:0100780)	2.59085216
36	Lipid accumulation in hepatocytes (HP:0006561)	2.56355976
37	Abnormality of the fovea (HP:0000493)	2.54327565
38	Abnormality of T cell physiology (HP:0011840)	2.53602130
39	Hypotrichosis (HP:0001006)	2.49508492
40	Degeneration of anterior horn cells (HP:0002398)	2.46902162
41	Abnormality of the anterior horn cell (HP:0006802)	2.46902162
42	Generalized aminoaciduria (HP:0002909)	2.43686484
43	Hypophosphatemic rickets (HP:0004912)	2.43322296
44	Recurrent bronchitis (HP:0002837)	2.38523806
45	Chronic mucocutaneous candidiasis (HP:0002728)	2.36844683
46	Recurrent cutaneous fungal infections (HP:0011370)	2.36844683
47	Anhidrosis (HP:0000970)	2.31182550
48	Congenital sensorineural hearing impairment (HP:0008527)	2.30215886
49	Amblyopia (HP:0000646)	2.29994054
50	IgM deficiency (HP:0002850)	2.24819692
51	Lymphopenia (HP:0001888)	2.22356573
52	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22170408
53	Hepatitis (HP:0012115)	2.19412506
54	Severe visual impairment (HP:0001141)	2.18812701
55	Exercise intolerance (HP:0003546)	2.17272240
56	Chronic diarrhea (HP:0002028)	2.16529464
57	Respiratory failure (HP:0002878)	2.11661979
58	Lactic acidosis (HP:0003128)	2.10941002
59	Hyperglycinemia (HP:0002154)	2.10748118
60	Renal duplication (HP:0000075)	2.10623179
61	Skin rash (HP:0000988)	2.09987041
62	Abnormal pupillary function (HP:0007686)	2.09051017
63	Cerebral edema (HP:0002181)	2.03885606
64	Abnormality of subcutaneous fat tissue (HP:0001001)	2.03603021
65	Exertional dyspnea (HP:0002875)	2.02858988
66	Aplasia/Hypoplasia of the macula (HP:0008059)	2.02254748
67	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.00842565
68	Birth length less than 3rd percentile (HP:0003561)	2.00533476
69	Cutaneous photosensitivity (HP:0000992)	1.98731456
70	Autoimmune hemolytic anemia (HP:0001890)	1.98426458
71	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96417831
72	Erythema (HP:0010783)	1.93831931
73	Hyperthyroidism (HP:0000836)	1.92905525
74	Attenuation of retinal blood vessels (HP:0007843)	1.92281767
75	Recurrent pneumonia (HP:0006532)	1.91733175
76	Increased serum lactate (HP:0002151)	1.91167618
77	Patent foramen ovale (HP:0001655)	1.89819461
78	Type I transferrin isoform profile (HP:0003642)	1.89261661
79	Microretrognathia (HP:0000308)	1.88051562
80	Urticaria (HP:0001025)	1.85655628
81	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.85494629
82	Lethargy (HP:0001254)	1.83804573
83	Premature skin wrinkling (HP:0100678)	1.83048528
84	Hypertensive crisis (HP:0100735)	1.82922123
85	Cutaneous melanoma (HP:0012056)	1.80613157
86	Abnormal gallbladder physiology (HP:0012438)	1.80401921
87	Cholecystitis (HP:0001082)	1.80401921
88	Ragged-red muscle fibers (HP:0003200)	1.80198292
89	Overlapping toe (HP:0001845)	1.80011294
90	Panhypogammaglobulinemia (HP:0003139)	1.78406109
91	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.75761015
92	Tubular atrophy (HP:0000092)	1.75609663
93	Abnormality of renal resorption (HP:0011038)	1.74669882
94	Recurrent lower respiratory tract infections (HP:0002783)	1.73730908
95	Increased IgM level (HP:0003496)	1.73566990
96	Neoplasm of the adrenal gland (HP:0100631)	1.72953747
97	Emphysema (HP:0002097)	1.72758772
98	Tubulointerstitial nephritis (HP:0001970)	1.71991712
99	Progressive microcephaly (HP:0000253)	1.71850624
100	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.70651492

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.98852349
2	FRK	4.32009134
3	VRK2	3.88724035
4	VRK1	3.73342985
5	BMPR2	3.48339254
6	BCKDK	3.34097542
7	MST4	3.26091931
8	MAPKAPK3	2.48365806
9	ZAK	2.43993756
10	TLK1	2.40604764
11	NUAK1	2.37882109
12	TAF1	2.37692518
13	NEK1	2.26339928
14	ARAF	2.25874256
15	MAP2K3	2.15477199
16	MAP3K12	2.04747213
17	BUB1	2.01067981
18	MAP2K6	1.96397918
19	DAPK3	1.95741003
20	MAP3K11	1.93940135
21	SMG1	1.80476202
22	STK10	1.66112692
23	RPS6KA5	1.61650756
24	FGFR2	1.54555992
25	FER	1.50045706
26	TESK1	1.38847236
27	MAP4K1	1.36594700
28	MAP3K1	1.26508488
29	LMTK2	1.24543656
30	PIM2	1.18413650
31	TBK1	1.18052306
32	NME2	1.14619643
33	DAPK1	1.14081593
34	AURKA	1.12089947
35	TESK2	1.09002524
36	ERBB3	1.03823205
37	KDR	1.03404868
38	MKNK2	1.02466336
39	AKT2	1.01648286
40	TSSK6	1.01019256
41	EIF2AK3	0.93656792
42	WNK4	0.91162304
43	IRAK3	0.90041087
44	KIT	0.89492280
45	ADRBK2	0.87285776
46	MAP3K13	0.87152552
47	MAP2K4	0.85200939
48	PLK3	0.79182341
49	CSNK1G1	0.74483189
50	SYK	0.72739509
51	STK4	0.71051382
52	CSNK1G3	0.71008472
53	IKBKB	0.68465196
54	AURKB	0.67950596
55	MAP3K14	0.67454827
56	CSNK1A1L	0.65095726
57	PRKCI	0.64085152
58	CCNB1	0.61703692
59	PRKCQ	0.59685970
60	MAP3K9	0.59134134
61	DYRK2	0.50212642
62	PAK4	0.49430971
63	MST1R	0.47000527
64	MOS	0.45215574
65	NEK9	0.44226450
66	ROCK1	0.42868947
67	CDC7	0.40953232
68	CSNK1G2	0.40793640
69	EIF2AK2	0.40375565
70	FGFR3	0.40169509
71	BRSK1	0.40033364
72	PIM1	0.38210027
73	CHEK2	0.37748011
74	LIMK1	0.36996671
75	HIPK2	0.36211762
76	GRK5	0.35417299
77	PLK1	0.34131245
78	EPHA2	0.33751329
79	PIK3CG	0.29461332
80	RPS6KB2	0.29069945
81	EIF2AK1	0.28844530
82	PBK	0.26888354
83	MKNK1	0.26253839
84	MAPKAPK5	0.25994826
85	ADRBK1	0.25711972
86	SIK2	0.24523328
87	MARK3	0.22397062
88	MAP3K8	0.21533449
89	PAK1	0.20040900
90	TAOK2	0.20031146
91	ATR	0.18625644
92	TNIK	0.18296470
93	PDK2	0.18291112
94	INSRR	0.18290466
95	ABL2	0.18201251
96	CSNK2A1	0.15846872
97	WEE1	0.15842424
98	PRKCD	0.14777412
99	LYN	0.14412326
100	CASK	0.14310752

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	5.65488097
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.37608096
3	Alcoholism_Homo sapiens_hsa05034	3.25743596
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.68162136
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.52407185
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.43060528
7	Allograft rejection_Homo sapiens_hsa05330	2.39861332
8	Proteasome_Homo sapiens_hsa03050	2.31942286
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.26960655
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.26714649
11	Asthma_Homo sapiens_hsa05310	2.23709374
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.23491215
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.92623816
14	Butanoate metabolism_Homo sapiens_hsa00650	1.69379485
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61292069
16	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.59922168
17	Protein export_Homo sapiens_hsa03060	1.58484932
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.57416624
19	Pentose phosphate pathway_Homo sapiens_hsa00030	1.56482206
20	Caffeine metabolism_Homo sapiens_hsa00232	1.54368400
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.53102223
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.48722962
23	Basal transcription factors_Homo sapiens_hsa03022	1.43606091
24	Folate biosynthesis_Homo sapiens_hsa00790	1.42133912
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.40646179
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.39267606
27	Parkinsons disease_Homo sapiens_hsa05012	1.37158823
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.34457011
29	Sulfur relay system_Homo sapiens_hsa04122	1.31575728
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.31497514
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.27590611
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.25051517
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.24455713
34	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.24259528
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.20584173
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16547519
37	RNA polymerase_Homo sapiens_hsa03020	1.12836773
38	Peroxisome_Homo sapiens_hsa04146	1.09806151
39	Viral carcinogenesis_Homo sapiens_hsa05203	1.07485581
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.07417749
41	Fatty acid elongation_Homo sapiens_hsa00062	1.07206693
42	RNA degradation_Homo sapiens_hsa03018	1.02107342
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.00332811
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.00315344
45	Homologous recombination_Homo sapiens_hsa03440	0.99774027
46	Viral myocarditis_Homo sapiens_hsa05416	0.99567221
47	One carbon pool by folate_Homo sapiens_hsa00670	0.98196965
48	Carbon metabolism_Homo sapiens_hsa01200	0.92878333
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92550031
50	Spliceosome_Homo sapiens_hsa03040	0.92493281
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90954631
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.89871696
53	Galactose metabolism_Homo sapiens_hsa00052	0.88697380
54	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.86591569
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.85820413
56	Huntingtons disease_Homo sapiens_hsa05016	0.84511330
57	Tyrosine metabolism_Homo sapiens_hsa00350	0.84113535
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82151186
59	Base excision repair_Homo sapiens_hsa03410	0.79281182
60	DNA replication_Homo sapiens_hsa03030	0.77692985
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.76915619
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75720627
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.72861097
64	Ribosome_Homo sapiens_hsa03010	0.70564005
65	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70206125
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67938879
67	Herpes simplex infection_Homo sapiens_hsa05168	0.67301254
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.67262526
69	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.67029633
70	Purine metabolism_Homo sapiens_hsa00230	0.63895541
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63246297
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.62716548
73	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58743255
74	Metabolic pathways_Homo sapiens_hsa01100	0.57664210
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.56512011
76	RNA transport_Homo sapiens_hsa03013	0.55207341
77	Alzheimers disease_Homo sapiens_hsa05010	0.53739929
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.52286931
79	p53 signaling pathway_Homo sapiens_hsa04115	0.51606972
80	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50400769
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49503505
82	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46002922
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45614094
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.45328562
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44525861
86	Fatty acid degradation_Homo sapiens_hsa00071	0.44186661
87	Mismatch repair_Homo sapiens_hsa03430	0.43657024
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43190548
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43179360
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.40719896
91	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.40680408
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39627075
93	Propanoate metabolism_Homo sapiens_hsa00640	0.39120227
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36919473
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.35909391
96	Leishmaniasis_Homo sapiens_hsa05140	0.35473648
97	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.33825568
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32794397
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32713722
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.26877806

HMGA1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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