HMGA1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.98733312
2motile cilium assembly (GO:0044458)8.90707909
3microtubule depolymerization (GO:0007019)8.12176440
4fusion of sperm to egg plasma membrane (GO:0007342)7.84860918
5chromosome condensation (GO:0030261)7.66455506
6acrosome reaction (GO:0007340)7.65981192
7sperm capacitation (GO:0048240)7.44910055
8cilium movement (GO:0003341)7.33222246
9DNA packaging (GO:0006323)6.87845169
10sperm motility (GO:0030317)6.85216815
11epithelial cilium movement (GO:0003351)6.30022679
12negative regulation of inclusion body assembly (GO:0090084)6.10927947
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.67162774
14microtubule polymerization or depolymerization (GO:0031109)5.65304395
15plasma membrane fusion (GO:0045026)5.63555870
16binding of sperm to zona pellucida (GO:0007339)5.48627469
17spermatid development (GO:0007286)5.27830097
18sperm-egg recognition (GO:0035036)5.24748598
19regulation of cilium movement (GO:0003352)4.83312450
20single strand break repair (GO:0000012)4.68174085
21nucleosome disassembly (GO:0006337)4.65369817
22protein-DNA complex disassembly (GO:0032986)4.65369817
23sexual reproduction (GO:0019953)4.53142404
24spermatid nucleus differentiation (GO:0007289)4.52181799
25regulation of interleukin-13 production (GO:0032656)4.48065234
26regulation of inclusion body assembly (GO:0090083)4.29277905
27glomerular epithelial cell development (GO:0072310)4.28099819
28multicellular organism reproduction (GO:0032504)4.27062125
29cell-cell recognition (GO:0009988)4.26957621
30left/right pattern formation (GO:0060972)4.26569646
31response to pheromone (GO:0019236)4.23810181
32microtubule severing (GO:0051013)4.20842249
33establishment of apical/basal cell polarity (GO:0035089)4.17673451
34reproduction (GO:0000003)4.17636809
35rRNA methylation (GO:0031167)4.02779297
36centriole assembly (GO:0098534)3.92815517
37cellular ketone body metabolic process (GO:0046950)3.91109158
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85599238
39ventricular system development (GO:0021591)3.84619199
40mitotic G1 DNA damage checkpoint (GO:0031571)3.83822446
41protein polyglutamylation (GO:0018095)3.79935311
42spermatogenesis (GO:0007283)3.78623778
43male gamete generation (GO:0048232)3.77002920
44phosphatidylethanolamine biosynthetic process (GO:0006646)3.69277873
45chromatin silencing (GO:0006342)3.63580901
46axoneme assembly (GO:0035082)3.62258385
47regulation of interleukin-5 production (GO:0032674)3.58885882
48intracellular estrogen receptor signaling pathway (GO:0030520)3.46643705
49protein depolymerization (GO:0051261)3.46178481
50regulation of histone H3-K27 methylation (GO:0061085)3.44971753
51rRNA modification (GO:0000154)3.43990950
52gamete generation (GO:0007276)3.42102383
53calcium ion-dependent exocytosis (GO:0017156)3.41964908
54establishment or maintenance of monopolar cell polarity (GO:0061339)3.40731563
55establishment of monopolar cell polarity (GO:0061162)3.40731563
56ketone body metabolic process (GO:1902224)3.40663341
57left/right axis specification (GO:0070986)3.39333746
58mesenchymal cell differentiation involved in kidney development (GO:0072161)3.34295769
59mesenchymal cell differentiation involved in renal system development (GO:2001012)3.34295769
60mitotic G1/S transition checkpoint (GO:0044819)3.32816834
61peptidyl-arginine omega-N-methylation (GO:0035247)3.31956374
62regulation of chromatin binding (GO:0035561)3.31542561
63membrane protein intracellular domain proteolysis (GO:0031293)3.30719111
64G1 DNA damage checkpoint (GO:0044783)3.27573679
65DNA conformation change (GO:0071103)3.24482891
66phosphatidylethanolamine metabolic process (GO:0046337)3.24337702
67protein retention in ER lumen (GO:0006621)3.23891800
68single fertilization (GO:0007338)3.21971058
69microtubule bundle formation (GO:0001578)3.17723789
70chaperone-mediated protein complex assembly (GO:0051131)3.15787644
71kidney mesenchyme development (GO:0072074)3.15308849
72metanephric mesenchyme development (GO:0072075)3.14050610
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02793120
74planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93511844
75nucleus organization (GO:0006997)2.91691644
76establishment of planar polarity (GO:0001736)2.88299944
77establishment of tissue polarity (GO:0007164)2.88299944
78embryonic camera-type eye development (GO:0031076)2.86547521
79germ cell development (GO:0007281)2.85352301
80lung epithelium development (GO:0060428)2.84920273
81mesonephros development (GO:0001823)2.84433101
82multicellular organismal reproductive process (GO:0048609)2.82034453
83positive regulation of Rab GTPase activity (GO:0032851)2.81078292
84regulation of Rab GTPase activity (GO:0032313)2.81078292
85cilium organization (GO:0044782)2.78075237
86peptidyl-arginine methylation (GO:0018216)2.76669633
87peptidyl-arginine N-methylation (GO:0035246)2.76669633
88lateral ventricle development (GO:0021670)2.76577524
89cilium assembly (GO:0042384)2.74130234
90RNA localization (GO:0006403)2.72576152
91histone H3-K9 demethylation (GO:0033169)2.70388186
92outflow tract septum morphogenesis (GO:0003148)2.69946413
93pattern specification involved in kidney development (GO:0061004)2.68824057
94negative regulation of histone methylation (GO:0031061)2.68763663
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67776941
96protein refolding (GO:0042026)2.66637090
97embryonic skeletal joint morphogenesis (GO:0060272)2.66141739
98primary alcohol catabolic process (GO:0034310)2.66006081
99cellular process involved in reproduction in multicellular organism (GO:0022412)2.65443207
100axonemal dynein complex assembly (GO:0070286)12.2206657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.87270341
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.64701790
3LXR_22292898_ChIP-Seq_THP-1_Human3.00487937
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80982030
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55353328
6ELF1_20517297_ChIP-Seq_JURKAT_Human2.54974833
7MYC_22102868_ChIP-Seq_BL_Human2.48522607
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44608916
9P68_20966046_ChIP-Seq_HELA_Human2.36446823
10RACK7_27058665_Chip-Seq_MCF-7_Human2.12104082
11SMC4_20622854_ChIP-Seq_HELA_Human2.10031998
12RUNX1_27514584_Chip-Seq_MCF-7_Human2.06901323
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91335347
14E2F1_20622854_ChIP-Seq_HELA_Human1.78065394
15CTCF_27219007_Chip-Seq_Bcells_Human1.75276359
16PHF8_20622854_ChIP-Seq_HELA_Human1.75133777
17BCOR_27268052_Chip-Seq_Bcells_Human1.74428254
18YY1_22570637_ChIP-Seq_MALME-3M_Human1.73189662
19VDR_21846776_ChIP-Seq_THP-1_Human1.72994973
20TP63_22573176_ChIP-Seq_HFKS_Human1.71652912
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71541758
22SA1_27219007_Chip-Seq_ERYTHROID_Human1.70607775
23TDRD3_21172665_ChIP-Seq_MCF-7_Human1.68667311
24TET1_21451524_ChIP-Seq_MESCs_Mouse1.64872587
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62326389
26BCL6_27268052_Chip-Seq_Bcells_Human1.60576338
27SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.60375834
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59601350
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.59014754
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58358276
31E2F7_22180533_ChIP-Seq_HELA_Human1.58032775
32TCF7_22412390_ChIP-Seq_EML_Mouse1.56581023
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55423457
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54555849
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50643843
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50158661
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48613279
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48065074
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.48034615
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46543710
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46524526
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.46174938
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45704207
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44482363
45KDM2B_26808549_Chip-Seq_DND41_Human1.42349544
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.41933889
47CTCF_20526341_ChIP-Seq_ESCs_Human1.41509228
48CREB1_26743006_Chip-Seq_LNCaP_Human1.40034209
49CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36350024
50CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35443042
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34241655
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34237604
53FOXP1_21924763_ChIP-Seq_HESCs_Human1.33590802
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33015812
55TP53_22127205_ChIP-Seq_IMR90_Human1.32154526
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31710859
57CTCF_21964334_Chip-Seq_Bcells_Human1.31667337
58NCOR1_26117541_ChIP-Seq_K562_Human1.31332367
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30774110
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29878159
61ATF3_27146783_Chip-Seq_COLON_Human1.27304672
62P300_27268052_Chip-Seq_Bcells_Human1.27199116
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26176937
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24970386
65RARA_24833708_ChIP-Seq_LIVER_Mouse1.24748074
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21577573
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21160171
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19565129
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18985596
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18490045
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17610245
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17018840
73KLF5_25053715_ChIP-Seq_YYC3_Human1.16895867
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15954992
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15599968
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15412353
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15209644
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14899478
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14671015
80DROSHA_22980978_ChIP-Seq_HELA_Human1.14509834
81KDM2B_26808549_Chip-Seq_K562_Human1.09861023
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08698665
83ERA_21632823_ChIP-Seq_H3396_Human1.08079793
84SA1_27219007_Chip-Seq_Bcells_Human1.07613125
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07262226
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06030595
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.05674249
88MAF_26560356_Chip-Seq_TH1_Human1.05202784
89RAC3_21632823_ChIP-Seq_H3396_Human1.04954508
90P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03253008
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03032469
92CIITA_25753668_ChIP-Seq_RAJI_Human1.02389714
93FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01785484
94ETS1_21867929_ChIP-Seq_TH2_Mouse1.01066913
95STAT1_20625510_ChIP-Seq_HELA_Human1.00839980
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.00686498
97UBF1/2_26484160_Chip-Seq_HMECs_Human0.99149748
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98845674
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.97621068
100UTX_26944678_Chip-Seq_JUKART_Human0.96433932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.61492164
2MP0000678_abnormal_parathyroid_gland3.69375388
3MP0001348_abnormal_lacrimal_gland3.64900279
4MP0002132_abnormal_respiratory_system3.50721715
5MP0005377_hearing/vestibular/ear_phenot2.89599861
6MP0003878_abnormal_ear_physiology2.89599861
7MP0005623_abnormal_meninges_morphology2.88842291
8MP0003698_abnormal_male_reproductive2.66295130
9MP0010234_abnormal_vibrissa_follicle2.61164725
10MP0002249_abnormal_larynx_morphology2.57751030
11MP0001929_abnormal_gametogenesis2.48737987
12MP0002653_abnormal_ependyma_morphology2.46465927
13MP0000613_abnormal_salivary_gland2.02572118
14MP0002163_abnormal_gland_morphology1.90337623
15MP0009053_abnormal_anal_canal1.83067010
16MP0004264_abnormal_extraembryonic_tissu1.82212957
17MP0002161_abnormal_fertility/fecundity1.70216584
18MP0003705_abnormal_hypodermis_morpholog1.67121788
19MP0005248_abnormal_Harderian_gland1.66507922
20MP0003693_abnormal_embryo_hatching1.63723246
21MP0000534_abnormal_ureter_morphology1.61006607
22MP0005379_endocrine/exocrine_gland_phen1.59982102
23MP0001849_ear_inflammation1.57242147
24MP0003077_abnormal_cell_cycle1.56779874
25MP0005670_abnormal_white_adipose1.51559161
26MP0002282_abnormal_trachea_morphology1.49649971
27MP0000566_synostosis1.43841013
28MP0003942_abnormal_urinary_system1.36423656
29MP0000049_abnormal_middle_ear1.36035745
30MP0004510_myositis1.35879238
31MP0005083_abnormal_biliary_tract1.35624340
32MP0004957_abnormal_blastocyst_morpholog1.34225148
33MP0001765_abnormal_ion_homeostasis1.32674150
34MP0008789_abnormal_olfactory_epithelium1.32022222
35MP0005076_abnormal_cell_differentiation1.30135914
36MP0000467_abnormal_esophagus_morphology1.29182852
37MP0010030_abnormal_orbit_morphology1.26763422
38MP0002796_impaired_skin_barrier1.24002433
39MP0005310_abnormal_salivary_gland1.23238109
40MP0003111_abnormal_nucleus_morphology1.23093390
41MP0008875_abnormal_xenobiotic_pharmacok1.20405818
42MP0000681_abnormal_thyroid_gland1.20142142
43MP0000733_abnormal_muscle_development1.20107454
44MP0003115_abnormal_respiratory_system1.18381564
45MP0002210_abnormal_sex_determination1.15436708
46MP0010094_abnormal_chromosome_stability1.15391307
47MP0003011_delayed_dark_adaptation1.12957474
48MP0001346_abnormal_lacrimal_gland1.11997010
49MP0002085_abnormal_embryonic_tissue1.10662508
50MP0002098_abnormal_vibrissa_morphology1.06710023
51MP0005499_abnormal_olfactory_system1.05303032
52MP0005394_taste/olfaction_phenotype1.05303032
53MP0002234_abnormal_pharynx_morphology1.04948696
54MP0005501_abnormal_skin_physiology1.03769943
55MP0002877_abnormal_melanocyte_morpholog1.03410648
56MP0002080_prenatal_lethality1.02733534
57MP0004133_heterotaxia1.01180155
58MP0010678_abnormal_skin_adnexa0.99878827
59MP0003091_abnormal_cell_migration0.99662995
60MP0004233_abnormal_muscle_weight0.97439514
61MP0001270_distended_abdomen0.96204774
62MP0001727_abnormal_embryo_implantation0.95715488
63MP0001145_abnormal_male_reproductive0.94065170
64MP0000350_abnormal_cell_proliferation0.88408784
65MP0008057_abnormal_DNA_replication0.88143457
66MP0001730_embryonic_growth_arrest0.87838870
67MP0003861_abnormal_nervous_system0.84808096
68MP0009780_abnormal_chondrocyte_physiolo0.84461562
69MP0000003_abnormal_adipose_tissue0.84165620
70MP0001340_abnormal_eyelid_morphology0.82866459
71MP0000313_abnormal_cell_death0.82292550
72MP0003718_maternal_effect0.81954864
73MP0002084_abnormal_developmental_patter0.81287745
74MP0005451_abnormal_body_composition0.80532676
75MP0002089_abnormal_postnatal_growth/wei0.79985850
76MP0003566_abnormal_cell_adhesion0.77701749
77MP0002277_abnormal_respiratory_mucosa0.77487897
78MP0005423_abnormal_somatic_nervous0.77448122
79MP0001984_abnormal_olfaction0.77073208
80MP0004782_abnormal_surfactant_physiolog0.75818172
81MP0000653_abnormal_sex_gland0.75638001
82MP0005645_abnormal_hypothalamus_physiol0.75174107
83MP0005380_embryogenesis_phenotype0.73864003
84MP0001672_abnormal_embryogenesis/_devel0.73864003
85MP0001873_stomach_inflammation0.72783705
86MP0002116_abnormal_craniofacial_bone0.72606188
87MP0004197_abnormal_fetal_growth/weight/0.72426028
88MP0000383_abnormal_hair_follicle0.71325950
89MP0008932_abnormal_embryonic_tissue0.70973648
90MP0003453_abnormal_keratinocyte_physiol0.70598595
91MP0009672_abnormal_birth_weight0.68959001
92MP0000026_abnormal_inner_ear0.68318319
93MP0008961_abnormal_basal_metabolism0.67336758
94MP0002932_abnormal_joint_morphology0.66857807
95MP0002092_abnormal_eye_morphology0.65289464
96MP0000762_abnormal_tongue_morphology0.65249699
97MP0000470_abnormal_stomach_morphology0.63124198
98MP0005409_darkened_coat_color0.61884374
99MP0009278_abnormal_bone_marrow0.61367292
100MP0005395_other_phenotype0.59625782

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.23397491
2Abnormal respiratory motile cilium morphology (HP:0005938)8.63893771
3Abnormal respiratory epithelium morphology (HP:0012253)8.63893771
4Absent/shortened dynein arms (HP:0200106)8.59180033
5Dynein arm defect of respiratory motile cilia (HP:0012255)8.59180033
6Abnormal respiratory motile cilium physiology (HP:0012261)8.35996037
7Abnormal ciliary motility (HP:0012262)8.10845922
8Rhinitis (HP:0012384)7.07129542
9Nasal polyposis (HP:0100582)6.41184227
10Bronchiectasis (HP:0002110)5.72308694
11Chronic bronchitis (HP:0004469)5.69007844
12Abnormality of the nasal mucosa (HP:0000433)5.02921816
13Male infertility (HP:0003251)4.77399719
14Infertility (HP:0000789)4.31261036
15Severe visual impairment (HP:0001141)4.21978364
16Recurrent sinusitis (HP:0011108)4.00140559
17Bell-shaped thorax (HP:0001591)3.89200206
18Recurrent otitis media (HP:0000403)3.47786597
19Bronchitis (HP:0012387)3.43105232
20Atelectasis (HP:0100750)3.16048583
21Chronic sinusitis (HP:0011109)3.12061026
22Unilateral renal agenesis (HP:0000122)2.61573742
23Hyperacusis (HP:0010780)2.57550165
24Occipital encephalocele (HP:0002085)2.57542855
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43137300
26Bony spicule pigmentary retinopathy (HP:0007737)2.42995794
27Tubulointerstitial nephritis (HP:0001970)2.42702182
28Progressive sensorineural hearing impairment (HP:0000408)2.34265491
29Hyperkalemia (HP:0002153)2.26564971
30Absent epiphyses (HP:0010577)2.12289898
31Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12289898
32Chronic hepatic failure (HP:0100626)2.11883013
33Hand muscle atrophy (HP:0009130)2.11024879
34Flattened epiphyses (HP:0003071)2.10484322
35Abnormal rod and cone electroretinograms (HP:0008323)2.06738071
36Progressive hearing impairment (HP:0001730)1.98017391
37Distal upper limb amyotrophy (HP:0007149)1.96137423
38Upper limb amyotrophy (HP:0009129)1.96137423
39Chronic otitis media (HP:0000389)1.95426925
40Recurrent bronchitis (HP:0002837)1.87797187
41Hypoplastic ischia (HP:0003175)1.85673833
42Abnormality of the aortic arch (HP:0012303)1.85269613
43Azoospermia (HP:0000027)1.80526332
44Short nail (HP:0001799)1.79110144
45Broad face (HP:0000283)1.76688218
46Hyperactive renin-angiotensin system (HP:0000841)1.75211319
47Renal dysplasia (HP:0000110)1.74885529
48Nephronophthisis (HP:0000090)1.73148662
49Renovascular hypertension (HP:0100817)1.72400338
50Resting tremor (HP:0002322)1.71725887
51Absent frontal sinuses (HP:0002688)1.68522083
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68302864
53Abnormality of the parathyroid morphology (HP:0011766)1.68249256
54Recurrent pneumonia (HP:0006532)1.65788630
55Short femoral neck (HP:0100864)1.64510523
56Glucose intolerance (HP:0000833)1.64295454
57Hyponatremia (HP:0002902)1.63169648
58Pancreatic fibrosis (HP:0100732)1.62879709
59Enlarged epiphyses (HP:0010580)1.62760975
60Distal lower limb muscle weakness (HP:0009053)1.60863195
61Cone-rod dystrophy (HP:0000548)1.60438300
62Abnormality of the distal phalanges of the toes (HP:0010182)1.58924104
63Cystic liver disease (HP:0006706)1.58682409
64Self-mutilation (HP:0000742)1.58177701
65Hypoparathyroidism (HP:0000829)1.57999265
66Epiphyseal dysplasia (HP:0002656)1.57581883
67Sclerocornea (HP:0000647)1.56778625
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.53034405
69Focal segmental glomerulosclerosis (HP:0000097)1.52825295
70Broad distal phalanx of finger (HP:0009836)1.50222220
71Long palpebral fissure (HP:0000637)1.50196451
72Down-sloping shoulders (HP:0200021)1.50040233
73Glossoptosis (HP:0000162)1.48934513
74Stage 5 chronic kidney disease (HP:0003774)1.48068952
75Abnormal spermatogenesis (HP:0008669)1.47646518
76Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.46072685
77Short ribs (HP:0000773)1.44817466
78Postaxial foot polydactyly (HP:0001830)1.44511063
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.44448739
80Obstructive sleep apnea (HP:0002870)1.43421338
81Asymmetric septal hypertrophy (HP:0001670)1.43415491
82Optic nerve coloboma (HP:0000588)1.43322197
83Polycystic kidney dysplasia (HP:0000113)1.42719155
84Intellectual disability, moderate (HP:0002342)1.41489832
85Abnormality of the ischium (HP:0003174)1.40720778
86Facial cleft (HP:0002006)1.40329804
87Attenuation of retinal blood vessels (HP:0007843)1.40267338
88Aplasia/Hypoplasia of the earlobes (HP:0009906)1.38716384
89Gastrointestinal stroma tumor (HP:0100723)1.37161622
90Hyperthyroidism (HP:0000836)1.35940860
91True hermaphroditism (HP:0010459)1.35758567
92Glomerulosclerosis (HP:0000096)1.35468447
93Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.35050124
94Insidious onset (HP:0003587)1.34904893
95Termporal pattern (HP:0011008)1.34904893
96Patellar dislocation (HP:0002999)1.33745175
97Abnormality of chloride homeostasis (HP:0011422)1.32736791
98Abnormal ventriculo-arterial connection (HP:0011563)1.30406010
99Transposition of the great arteries (HP:0001669)1.30406010
100Abnormal connection of the cardiac segments (HP:0011545)1.30406010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.66773586
2SMG14.56669142
3MAPK154.03334002
4EPHA23.75718568
5TRIB33.67197312
6CDK123.07487406
7EEF2K3.06088011
8DDR22.96964946
9PLK42.63298466
10NME22.50294750
11MAP3K102.34593809
12MST1R2.22422643
13LMTK22.12941442
14ICK2.00302460
15MAP4K21.96310078
16TLK11.66938738
17SIK11.65880282
18VRK21.55002961
19CDK71.51956227
20INSRR1.49287450
21RPS6KB21.28211551
22ARAF1.28067338
23ERN11.26346096
24IRAK31.25575936
25AURKA1.23915135
26PRKD31.23255177
27MAP2K21.20578869
28BRD41.19049506
29STK381.11705713
30MAP3K81.11150625
31TESK21.09812816
32CDK41.07068437
33PKN21.06578402
34PDPK11.05457825
35MAP3K91.00460185
36BUB11.00049648
37RPS6KA20.92259450
38MTOR0.92104860
39KSR20.88405702
40PASK0.85631832
41VRK10.84711392
42CDC70.82214873
43PNCK0.81340268
44TAF10.80261415
45BRAF0.79933595
46SCYL20.75170193
47CDK90.74433686
48TTK0.72875833
49DYRK1B0.72194310
50MST40.69909104
51PDK10.69438108
52FGFR40.67176206
53WNK10.66778704
54MAPKAPK30.66334063
55MUSK0.64905772
56BLK0.64707458
57PAK40.63174235
58CHEK10.63153370
59CHEK20.62625116
60CDK80.62562175
61NME10.62328851
62NEK60.61001458
63TAOK10.58398594
64PRPF4B0.58187895
65AKT20.57575752
66MARK20.54196862
67LATS20.53574476
68BRSK10.51003518
69HIPK20.50120514
70CDK20.48795548
71NEK90.48495205
72CAMK1G0.45358202
73SIK20.44231537
74RIPK40.43713520
75MAP3K20.43432542
76STK100.43150690
77MAPK110.42574123
78PIM20.40820025
79PTK60.39962184
80CDK10.39073188
81PRKCI0.38811694
82PRKG20.35677020
83MET0.34516710
84RPS6KC10.33264006
85RPS6KL10.33264006
86RIPK10.33124655
87TAOK20.32232789
88PTK2B0.31703198
89AURKB0.31458830
90MAP3K10.31336477
91CHUK0.30419232
92RPS6KA10.30286012
93LRRK20.29205660
94GSK3B0.29065720
95ROCK10.28469891
96PRKD20.28117175
97LATS10.27048339
98MAPK90.26809263
99MAP3K110.26780054
100ALK0.26473103

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.29227598
2Phenylalanine metabolism_Homo sapiens_hsa003603.34992480
3Systemic lupus erythematosus_Homo sapiens_hsa053222.22475139
4Fatty acid biosynthesis_Homo sapiens_hsa000612.17108656
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08904092
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.92959513
7Alcoholism_Homo sapiens_hsa050341.88624628
8DNA replication_Homo sapiens_hsa030301.83888429
9Viral carcinogenesis_Homo sapiens_hsa052031.77050976
10Base excision repair_Homo sapiens_hsa034101.76254204
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75227889
12Spliceosome_Homo sapiens_hsa030401.71524468
13Notch signaling pathway_Homo sapiens_hsa043301.69584573
14Tyrosine metabolism_Homo sapiens_hsa003501.68747766
15Thyroid cancer_Homo sapiens_hsa052161.58297140
16RNA transport_Homo sapiens_hsa030131.57413900
17Biosynthesis of amino acids_Homo sapiens_hsa012301.54654893
18Viral myocarditis_Homo sapiens_hsa054161.53853642
19Bladder cancer_Homo sapiens_hsa052191.50297105
20Pentose phosphate pathway_Homo sapiens_hsa000301.50256749
21B cell receptor signaling pathway_Homo sapiens_hsa046621.49634766
22mRNA surveillance pathway_Homo sapiens_hsa030151.48048112
23Non-small cell lung cancer_Homo sapiens_hsa052231.45149067
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.43844941
25Acute myeloid leukemia_Homo sapiens_hsa052211.32530902
26Antigen processing and presentation_Homo sapiens_hsa046121.31395124
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30349532
28Endometrial cancer_Homo sapiens_hsa052131.29519844
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29459066
30Chronic myeloid leukemia_Homo sapiens_hsa052201.25267595
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24157652
32Allograft rejection_Homo sapiens_hsa053301.17220590
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16592510
34Autoimmune thyroid disease_Homo sapiens_hsa053201.16521255
35Nucleotide excision repair_Homo sapiens_hsa034201.09229900
36Tight junction_Homo sapiens_hsa045301.08846724
37Influenza A_Homo sapiens_hsa051641.07492079
38Sulfur relay system_Homo sapiens_hsa041221.04758431
39Prostate cancer_Homo sapiens_hsa052151.04653607
40VEGF signaling pathway_Homo sapiens_hsa043701.02411681
41Epstein-Barr virus infection_Homo sapiens_hsa051691.01029498
42Adherens junction_Homo sapiens_hsa045200.99789622
43Pancreatic cancer_Homo sapiens_hsa052120.99395749
44Endocytosis_Homo sapiens_hsa041440.99280125
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98290492
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98107852
47Herpes simplex infection_Homo sapiens_hsa051680.95479594
48Cell cycle_Homo sapiens_hsa041100.92803714
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90326886
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89713729
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87143027
52Hedgehog signaling pathway_Homo sapiens_hsa043400.84460887
53Type I diabetes mellitus_Homo sapiens_hsa049400.84216544
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83567925
55Olfactory transduction_Homo sapiens_hsa047400.80440691
56Estrogen signaling pathway_Homo sapiens_hsa049150.79690066
57mTOR signaling pathway_Homo sapiens_hsa041500.79355543
58Mismatch repair_Homo sapiens_hsa034300.79133782
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79014832
60Carbon metabolism_Homo sapiens_hsa012000.78644808
61Graft-versus-host disease_Homo sapiens_hsa053320.78085692
62Fructose and mannose metabolism_Homo sapiens_hsa000510.77577532
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77143514
64Choline metabolism in cancer_Homo sapiens_hsa052310.73723368
65MicroRNAs in cancer_Homo sapiens_hsa052060.72634992
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70415826
67Hippo signaling pathway_Homo sapiens_hsa043900.69724626
68HTLV-I infection_Homo sapiens_hsa051660.68787873
69Type II diabetes mellitus_Homo sapiens_hsa049300.68603436
70ErbB signaling pathway_Homo sapiens_hsa040120.68341427
71Glioma_Homo sapiens_hsa052140.66626304
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.64954603
73Histidine metabolism_Homo sapiens_hsa003400.64447415
74Colorectal cancer_Homo sapiens_hsa052100.63845901
75Basal cell carcinoma_Homo sapiens_hsa052170.63696665
76Apoptosis_Homo sapiens_hsa042100.62914655
77beta-Alanine metabolism_Homo sapiens_hsa004100.62869841
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.60467374
79Melanoma_Homo sapiens_hsa052180.59644431
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58476397
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57242105
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57155317
83Oocyte meiosis_Homo sapiens_hsa041140.55859416
84Proteoglycans in cancer_Homo sapiens_hsa052050.55264283
85Insulin signaling pathway_Homo sapiens_hsa049100.53883431
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53596575
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53212867
88Hepatitis B_Homo sapiens_hsa051610.52788039
89Inositol phosphate metabolism_Homo sapiens_hsa005620.52008863
90Hepatitis C_Homo sapiens_hsa051600.51723219
91Arginine and proline metabolism_Homo sapiens_hsa003300.50984002
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.48418416
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47670276
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47253000
95Glutathione metabolism_Homo sapiens_hsa004800.46562053
96Pyrimidine metabolism_Homo sapiens_hsa002400.46360060
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46157362
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.46122298
99AMPK signaling pathway_Homo sapiens_hsa041520.42939935
100Renal cell carcinoma_Homo sapiens_hsa052110.42213593

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