HMGB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.09607170
2CENP-A containing nucleosome assembly (GO:0034080)5.08509535
3DNA strand elongation involved in DNA replication (GO:0006271)5.05468557
4telomere maintenance via semi-conservative replication (GO:0032201)5.05109389
5chromatin remodeling at centromere (GO:0031055)4.88588141
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.88488685
7DNA strand elongation (GO:0022616)4.87497038
8DNA double-strand break processing (GO:0000729)4.71285995
9DNA unwinding involved in DNA replication (GO:0006268)4.69460687
10telomere maintenance via recombination (GO:0000722)4.67687447
11mitotic recombination (GO:0006312)4.66506156
12DNA replication initiation (GO:0006270)4.66408501
13ribosomal small subunit assembly (GO:0000028)4.64432648
14establishment of integrated proviral latency (GO:0075713)4.61214722
15kinetochore assembly (GO:0051382)4.44088907
16DNA replication-independent nucleosome assembly (GO:0006336)4.40859822
17DNA replication-independent nucleosome organization (GO:0034724)4.40859822
18mitotic metaphase plate congression (GO:0007080)4.37005960
19protein localization to kinetochore (GO:0034501)4.18055241
20attachment of spindle microtubules to kinetochore (GO:0008608)4.12355095
21metaphase plate congression (GO:0051310)4.10048281
22DNA replication checkpoint (GO:0000076)4.09714271
23telomere maintenance via telomere lengthening (GO:0010833)4.09599955
24nucleotide-excision repair, DNA gap filling (GO:0006297)4.00138311
25establishment of chromosome localization (GO:0051303)3.99368772
26histone exchange (GO:0043486)3.93664420
27proteasome assembly (GO:0043248)3.93393459
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.92474633
29mitotic chromosome condensation (GO:0007076)3.88999001
30viral mRNA export from host cell nucleus (GO:0046784)3.85973589
31regulation of centriole replication (GO:0046599)3.78591002
32meiotic chromosome segregation (GO:0045132)3.76567405
33nucleobase biosynthetic process (GO:0046112)3.71603058
34purine nucleobase biosynthetic process (GO:0009113)3.60774186
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57471490
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56776589
37regulation of mitotic spindle checkpoint (GO:1903504)3.56776589
38mitotic sister chromatid segregation (GO:0000070)3.55688496
39protein localization to chromosome, centromeric region (GO:0071459)3.54638214
40IMP biosynthetic process (GO:0006188)3.54571989
41sister chromatid segregation (GO:0000819)3.52934686
42DNA damage response, detection of DNA damage (GO:0042769)3.52315952
43mitotic G2/M transition checkpoint (GO:0044818)3.49415489
44establishment of viral latency (GO:0019043)3.45286951
45telomere maintenance (GO:0000723)3.45132790
46telomere organization (GO:0032200)3.43156363
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.37457132
48regulation of spindle organization (GO:0090224)3.35353875
49non-recombinational repair (GO:0000726)3.34420162
50double-strand break repair via nonhomologous end joining (GO:0006303)3.34420162
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32795914
52RNA-dependent DNA replication (GO:0006278)3.30768818
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27440882
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24099342
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23672444
56transcription-coupled nucleotide-excision repair (GO:0006283)3.21962461
57mismatch repair (GO:0006298)3.21799017
58negative regulation of ligase activity (GO:0051352)3.21264260
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21264260
60ATP-dependent chromatin remodeling (GO:0043044)3.21136271
61regulation of nuclear cell cycle DNA replication (GO:0033262)3.21039505
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20793522
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18995242
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18482100
65mitotic nuclear envelope disassembly (GO:0007077)3.18181951
66spindle checkpoint (GO:0031577)3.17969175
67regulation of helicase activity (GO:0051095)3.16441947
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.14118950
69DNA deamination (GO:0045006)3.13182085
70spliceosomal snRNP assembly (GO:0000387)3.12904162
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12037812
72postreplication repair (GO:0006301)3.11914313
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.11409601
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11409601
75* DNA ligation (GO:0006266)3.10655894
76replication fork processing (GO:0031297)3.09764614
77protein neddylation (GO:0045116)3.08080933
78chromosome segregation (GO:0007059)3.07020939
79deoxyribonucleotide biosynthetic process (GO:0009263)3.06745949
80centriole replication (GO:0007099)3.06074045
81mitotic sister chromatid cohesion (GO:0007064)3.05441056
82DNA replication-dependent nucleosome organization (GO:0034723)3.05283580
83DNA replication-dependent nucleosome assembly (GO:0006335)3.05283580
84spindle assembly checkpoint (GO:0071173)3.04781749
85histone mRNA metabolic process (GO:0008334)3.04008479
86microtubule depolymerization (GO:0007019)3.03971388
87IMP metabolic process (GO:0046040)3.03944995
88regulation of centrosome cycle (GO:0046605)3.02344115
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.02258841
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02258841
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02258841
92negative regulation of sister chromatid segregation (GO:0033046)3.02258841
93negative regulation of RNA splicing (GO:0033119)3.01903810
94chaperone-mediated protein transport (GO:0072321)2.99739534
95negative regulation of mitosis (GO:0045839)2.98592203
96ribosome assembly (GO:0042255)2.98376764
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98198245
98nuclear pore organization (GO:0006999)2.97931951
99protein K6-linked ubiquitination (GO:0085020)2.97744406
100definitive hemopoiesis (GO:0060216)2.97113318
101negative regulation of DNA recombination (GO:0045910)2.96837492
102resolution of meiotic recombination intermediates (GO:0000712)2.95934062
103negative regulation of chromosome segregation (GO:0051985)2.95797519
104chromatin assembly or disassembly (GO:0006333)2.94551929
105cell cycle G1/S phase transition (GO:0044843)2.93680809
106G1/S transition of mitotic cell cycle (GO:0000082)2.93680809
107cullin deneddylation (GO:0010388)2.93150647
108intra-S DNA damage checkpoint (GO:0031573)2.93091039
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92178553
110maturation of SSU-rRNA (GO:0030490)2.91470731
111mitotic spindle assembly checkpoint (GO:0007094)2.90555960
112regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90501218
113mitotic cell cycle (GO:0000278)2.89580978
114nuclear envelope disassembly (GO:0051081)2.86518726
115membrane disassembly (GO:0030397)2.86518726
116DNA replication (GO:0006260)2.85892933
117mitotic spindle checkpoint (GO:0071174)2.85060677
118RNA splicing, via transesterification reactions (GO:0000375)2.84933644
119* DNA topological change (GO:0006265)2.84278490
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83826346
121mRNA splicing, via spliceosome (GO:0000398)2.83826346
122regulation of sister chromatid segregation (GO:0033045)2.83044390
123regulation of mitotic sister chromatid separation (GO:0010965)2.83044390
124regulation of mitotic sister chromatid segregation (GO:0033047)2.83044390
125regulation of DNA endoreduplication (GO:0032875)2.81952758
126regulation of chromosome segregation (GO:0051983)2.81799007
127DNA duplex unwinding (GO:0032508)2.81676190
128DNA geometric change (GO:0032392)2.81209694
129DNA catabolic process, exonucleolytic (GO:0000738)2.80528134
130spliceosomal complex assembly (GO:0000245)2.80169856
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79343258
132maturation of 5.8S rRNA (GO:0000460)2.78875246
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78844383
134termination of RNA polymerase II transcription (GO:0006369)2.78332682
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77842192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.06154217
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.58464147
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.97171291
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77891270
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.64888293
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.08104617
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94118846
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84963762
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.81401967
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70090293
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69873065
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61108757
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60137393
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55599981
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44036285
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.33735954
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.33679675
18AR_21909140_ChIP-Seq_LNCAP_Human2.29278939
19VDR_23849224_ChIP-Seq_CD4+_Human2.28057181
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27805755
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27530491
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27262785
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22276389
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21432984
25ELK1_19687146_ChIP-ChIP_HELA_Human2.18685541
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18625061
27FOXP3_21729870_ChIP-Seq_TREG_Human2.11507911
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06942107
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06390394
30XRN2_22483619_ChIP-Seq_HELA_Human2.05568123
31HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03894026
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03373625
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03302865
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02073104
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01735725
36E2F7_22180533_ChIP-Seq_HELA_Human10.2716684
37DCP1A_22483619_ChIP-Seq_HELA_Human1.86839287
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82868842
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81131045
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80390295
41TTF2_22483619_ChIP-Seq_HELA_Human1.79562035
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77150795
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.75483338
44CIITA_25753668_ChIP-Seq_RAJI_Human1.71123457
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.67639332
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67496596
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65744956
48FUS_26573619_Chip-Seq_HEK293_Human1.63373730
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60801455
50GABP_19822575_ChIP-Seq_HepG2_Human1.60368350
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.55141164
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53969680
53ZNF274_21170338_ChIP-Seq_K562_Hela1.49862480
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47071410
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46295672
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44292538
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44033499
58* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40147922
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40120517
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37021272
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36341971
62VDR_22108803_ChIP-Seq_LS180_Human1.34053901
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30747929
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.30579165
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27609016
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26656745
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25832066
68IGF1R_20145208_ChIP-Seq_DFB_Human1.24892061
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18542464
70* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18002640
71MYC_18940864_ChIP-ChIP_HL60_Human1.17861193
72KDM5A_27292631_Chip-Seq_BREAST_Human1.16371621
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15887478
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12431668
75TAF15_26573619_Chip-Seq_HEK293_Human1.10230562
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10015496
77IRF1_19129219_ChIP-ChIP_H3396_Human1.07246797
78MYC_22102868_ChIP-Seq_BL_Human1.07116767
79* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06153425
80* SPI1_23547873_ChIP-Seq_NB4_Human1.05232344
81SCL_19346495_ChIP-Seq_HPC-7_Human1.04350719
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.02571489
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99955678
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.98929621
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94205105
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91450482
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91067267
88* P300_19829295_ChIP-Seq_ESCs_Human0.90419305
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86105692
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85017766
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84905355
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83371339
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82683070
94TFEB_21752829_ChIP-Seq_HELA_Human0.82183820
95* EWS_26573619_Chip-Seq_HEK293_Human0.81421576
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81357205
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76874672
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76514025
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75688934
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73429845
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73250248
102CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72673957
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72474467
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.71504414
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71467389
106STAT4_19710469_ChIP-ChIP_TH1__Mouse0.71022993
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70534571
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.69541914
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.69371628
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68563425
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68440625
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68174207
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67790313
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67554740
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.67145160
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.66821671
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.66024500
118* MYB_26560356_Chip-Seq_TH2_Human0.65523534
119VDR_21846776_ChIP-Seq_THP-1_Human0.65084864
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.64399579
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.62711195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.48188491
2MP0003693_abnormal_embryo_hatching4.39147407
3MP0008057_abnormal_DNA_replication4.06156628
4MP0003111_abnormal_nucleus_morphology3.80891431
5MP0003077_abnormal_cell_cycle3.60791270
6MP0002396_abnormal_hematopoietic_system3.57468192
7MP0008007_abnormal_cellular_replicative3.52596820
8MP0008058_abnormal_DNA_repair3.43173323
9MP0004957_abnormal_blastocyst_morpholog3.38940376
10MP0003123_paternal_imprinting2.40530337
11MP0006054_spinal_hemorrhage2.36651988
12MP0008932_abnormal_embryonic_tissue2.24086197
13MP0003890_abnormal_embryonic-extraembry2.10427981
14MP0004808_abnormal_hematopoietic_stem2.09724429
15MP0003786_premature_aging2.05909793
16MP0008877_abnormal_DNA_methylation2.02533664
17MP0001529_abnormal_vocalization1.92540587
18MP0006072_abnormal_retinal_apoptosis1.89876753
19MP0000490_abnormal_crypts_of1.83669311
20MP0000566_synostosis1.80976205
21MP0002132_abnormal_respiratory_system1.78720738
22MP0003136_yellow_coat_color1.76340662
23MP0003121_genomic_imprinting1.72975992
24MP0003763_abnormal_thymus_physiology1.68167745
25MP0002938_white_spotting1.66303793
26MP0002102_abnormal_ear_morphology1.61977707
27MP0009697_abnormal_copulation1.61622834
28MP0000350_abnormal_cell_proliferation1.60092105
29MP0008789_abnormal_olfactory_epithelium1.59282969
30MP0005397_hematopoietic_system_phenotyp1.51938244
31MP0001545_abnormal_hematopoietic_system1.51938244
32MP0006292_abnormal_olfactory_placode1.51061775
33MP0003943_abnormal_hepatobiliary_system1.48494080
34MP0002160_abnormal_reproductive_system1.39707938
35MP0002095_abnormal_skin_pigmentation1.39654750
36MP0002736_abnormal_nociception_after1.39648754
37MP0001730_embryonic_growth_arrest1.32365199
38MP0003787_abnormal_imprinting1.31266355
39MP0004147_increased_porphyrin_level1.30978925
40MP0009672_abnormal_birth_weight1.29218156
41MP0009379_abnormal_foot_pigmentation1.28666806
42MP0002398_abnormal_bone_marrow1.28590654
43MP0002019_abnormal_tumor_incidence1.26079304
44MP0000313_abnormal_cell_death1.24224776
45MP0001188_hyperpigmentation1.24016478
46MP0003119_abnormal_digestive_system1.22735304
47MP0003315_abnormal_perineum_morphology1.21985359
48MP0000703_abnormal_thymus_morphology1.21981912
49MP0002751_abnormal_autonomic_nervous1.19053336
50MP0005075_abnormal_melanosome_morpholog1.18549689
51MP0010030_abnormal_orbit_morphology1.18162870
52MP0003567_abnormal_fetal_cardiomyocyte1.16484733
53MP0005499_abnormal_olfactory_system1.16145830
54MP0005394_taste/olfaction_phenotype1.16145830
55MP0001672_abnormal_embryogenesis/_devel1.16012774
56MP0005380_embryogenesis_phenotype1.16012774
57MP0005389_reproductive_system_phenotype1.15883721
58MP0002233_abnormal_nose_morphology1.15432872
59MP0006035_abnormal_mitochondrial_morpho1.15221068
60MP0001697_abnormal_embryo_size1.12193833
61MP0003806_abnormal_nucleotide_metabolis1.11622012
62MP0001119_abnormal_female_reproductive1.09785567
63MP0002163_abnormal_gland_morphology1.09540650
64MP0000689_abnormal_spleen_morphology1.07200953
65MP0002722_abnormal_immune_system1.06802069
66MP0002009_preneoplasia1.06344203
67MP0001485_abnormal_pinna_reflex1.05511140
68MP0010307_abnormal_tumor_latency1.04894372
69MP0009053_abnormal_anal_canal1.04330240
70MP0005253_abnormal_eye_physiology1.04220277
71MP0003984_embryonic_growth_retardation1.04186239
72MP0006036_abnormal_mitochondrial_physio1.03993748
73MP0002210_abnormal_sex_determination1.03837271
74MP0004782_abnormal_surfactant_physiolog1.03138669
75MP0002111_abnormal_tail_morphology1.03095990
76MP0000465_gastrointestinal_hemorrhage1.02013257
77MP0002080_prenatal_lethality1.01838018
78MP0002088_abnormal_embryonic_growth/wei1.00189821
79MP0004133_heterotaxia0.99294718
80MP0009333_abnormal_splenocyte_physiolog0.99034004
81MP0002234_abnormal_pharynx_morphology0.98602819
82MP0002697_abnormal_eye_size0.96814066
83MP0002429_abnormal_blood_cell0.96724482
84MP0000015_abnormal_ear_pigmentation0.96687969
85MP0000631_abnormal_neuroendocrine_gland0.96069907
86MP0001835_abnormal_antigen_presentation0.95664620
87MP0005084_abnormal_gallbladder_morpholo0.94872614
88MP0003880_abnormal_central_pattern0.94599871
89MP0005174_abnormal_tail_pigmentation0.94381843
90MP0003941_abnormal_skin_development0.92928833
91MP0003942_abnormal_urinary_system0.92594834
92MP0009703_decreased_birth_body0.91878323
93MP0002085_abnormal_embryonic_tissue0.90556668
94MP0005409_darkened_coat_color0.89793123
95MP0001293_anophthalmia0.88886209
96MP0001919_abnormal_reproductive_system0.88571855
97MP0000716_abnormal_immune_system0.88063519
98MP0005391_vision/eye_phenotype0.86487939
99MP0000537_abnormal_urethra_morphology0.85908183
100MP0010352_gastrointestinal_tract_polyps0.84992527
101MP0004197_abnormal_fetal_growth/weight/0.84771458
102MP0002086_abnormal_extraembryonic_tissu0.84202938
103MP0003861_abnormal_nervous_system0.83081809
104MP0003186_abnormal_redox_activity0.81402657
105MP0001145_abnormal_male_reproductive0.80985162
106MP0008995_early_reproductive_senescence0.79612194
107MP0000049_abnormal_middle_ear0.79281226
108MP0002006_tumorigenesis0.78553437
109MP0003698_abnormal_male_reproductive0.78552232
110MP0000653_abnormal_sex_gland0.77279250
111MP0002166_altered_tumor_susceptibility0.76912567
112MP0002420_abnormal_adaptive_immunity0.76467015
113MP0003755_abnormal_palate_morphology0.75297340
114MP0000681_abnormal_thyroid_gland0.74549417
115MP0001853_heart_inflammation0.74206104
116MP0000647_abnormal_sebaceous_gland0.73884782
117MP0001819_abnormal_immune_cell0.73308888
118MP0005671_abnormal_response_to0.71460319
119MP0004215_abnormal_myocardial_fiber0.71066317
120MP0003937_abnormal_limbs/digits/tail_de0.70629819
121MP0005367_renal/urinary_system_phenotyp0.69855333
122MP0000516_abnormal_urinary_system0.69855333
123* MP0001177_atelectasis0.69053279
124MP0001929_abnormal_gametogenesis0.68599047
125MP0000678_abnormal_parathyroid_gland0.68402234
126MP0005408_hypopigmentation0.67856364
127MP0001986_abnormal_taste_sensitivity0.67609612
128MP0001879_abnormal_lymphatic_vessel0.67533943
129MP0000372_irregular_coat_pigmentation0.66751517
130MP0000858_altered_metastatic_potential0.66741343
131MP0000428_abnormal_craniofacial_morphol0.66129595
132MP0002084_abnormal_developmental_patter0.66068480
133MP0000778_abnormal_nervous_system0.65299149
134MP0003718_maternal_effect0.64621049
135MP0003115_abnormal_respiratory_system0.64467636
136MP0001186_pigmentation_phenotype0.64330232
137MP0001286_abnormal_eye_development0.63850407
138MP0008872_abnormal_physiological_respon0.63509998
139MP0002452_abnormal_antigen_presenting0.63487983
140MP0002092_abnormal_eye_morphology0.63431999
141MP0001968_abnormal_touch/_nociception0.62562854
142MP0000358_abnormal_cell_content/0.61888861
143MP0003938_abnormal_ear_development0.61388920

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.32578311
2Birth length less than 3rd percentile (HP:0003561)4.07630404
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01536905
4Aplastic anemia (HP:0001915)3.92836913
5Abnormality of the labia minora (HP:0012880)3.74724718
611 pairs of ribs (HP:0000878)3.71592503
7Reticulocytopenia (HP:0001896)3.30671863
8Abnormal lung lobation (HP:0002101)3.28481595
9Nephroblastoma (Wilms tumor) (HP:0002667)3.16533508
10Abnormal number of erythroid precursors (HP:0012131)3.12556567
11Abnormality of chromosome stability (HP:0003220)3.11165378
12Meckel diverticulum (HP:0002245)3.10232209
13Embryonal renal neoplasm (HP:0011794)3.01479150
14Abnormality of the ileum (HP:0001549)2.95843029
15Patellar aplasia (HP:0006443)2.95512786
16Thrombocytosis (HP:0001894)2.93888247
17Abnormality of the preputium (HP:0100587)2.91127364
18Oral leukoplakia (HP:0002745)2.89793537
19Myelodysplasia (HP:0002863)2.86385196
20Acute necrotizing encephalopathy (HP:0006965)2.85996536
21Colon cancer (HP:0003003)2.81746842
22Abnormality of cells of the erythroid lineage (HP:0012130)2.78501724
23Aplasia/Hypoplasia of the patella (HP:0006498)2.76833172
24Acute encephalopathy (HP:0006846)2.70883612
25Syringomyelia (HP:0003396)2.64707300
26Spinal cord lesions (HP:0100561)2.64707300
27Bone marrow hypocellularity (HP:0005528)2.60507959
28Increased hepatocellular lipid droplets (HP:0006565)2.60494478
29Small intestinal stenosis (HP:0012848)2.57011167
30Duodenal stenosis (HP:0100867)2.57011167
31Type I transferrin isoform profile (HP:0003642)2.54897537
32Breast hypoplasia (HP:0003187)2.51389747
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.50920089
34Abnormality of the anterior horn cell (HP:0006802)2.48689793
35Degeneration of anterior horn cells (HP:0002398)2.48689793
36Abnormal mitochondria in muscle tissue (HP:0008316)2.48522102
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.42473841
38Volvulus (HP:0002580)2.41701338
39Mitochondrial inheritance (HP:0001427)2.41283644
40Progressive macrocephaly (HP:0004481)2.37698908
41Ectopic kidney (HP:0000086)2.36784552
42Increased CSF lactate (HP:0002490)2.35866100
43Septo-optic dysplasia (HP:0100842)2.32904639
44Short middle phalanx of the 5th finger (HP:0004220)2.30943361
45Lipid accumulation in hepatocytes (HP:0006561)2.29480730
46Sloping forehead (HP:0000340)2.28188935
47Cortical dysplasia (HP:0002539)2.27684736
48IgM deficiency (HP:0002850)2.26946977
49True hermaphroditism (HP:0010459)2.26426666
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24953406
51Short 4th metacarpal (HP:0010044)2.24953406
52Medulloblastoma (HP:0002885)2.23751819
53Premature graying of hair (HP:0002216)2.23172366
54Optic nerve coloboma (HP:0000588)2.22454091
55Reduced antithrombin III activity (HP:0001976)2.18320859
56Abnormality of the renal collecting system (HP:0004742)2.17952735
57Clubbing of toes (HP:0100760)2.16263312
58Methylmalonic acidemia (HP:0002912)2.13524958
59Acute myeloid leukemia (HP:0004808)2.13158960
60Diastasis recti (HP:0001540)2.13023255
61Hyperglycinemia (HP:0002154)2.12962077
62Abnormality of the prostate (HP:0008775)2.12254625
63Absent radius (HP:0003974)2.10472203
64Rhabdomyosarcoma (HP:0002859)2.08941045
65Glioma (HP:0009733)2.08112399
66Ependymoma (HP:0002888)2.05842330
67Duplicated collecting system (HP:0000081)2.05651700
68Hepatocellular necrosis (HP:0001404)2.04747384
69Intestinal atresia (HP:0011100)2.04228065
70Long clavicles (HP:0000890)2.03960663
71Absent forearm bone (HP:0003953)2.03831449
72Aplasia involving forearm bones (HP:0009822)2.03831449
73Cerebral edema (HP:0002181)2.01242881
74Petechiae (HP:0000967)2.00998284
75Abnormality of the duodenum (HP:0002246)1.99415889
76Multiple enchondromatosis (HP:0005701)1.98567140
77Pancytopenia (HP:0001876)1.97268621
78Selective tooth agenesis (HP:0001592)1.95782716
79Impulsivity (HP:0100710)1.95492979
80Rough bone trabeculation (HP:0100670)1.94835406
81Lymphoma (HP:0002665)1.93816993
82Cutaneous melanoma (HP:0012056)1.92736933
83Congenital, generalized hypertrichosis (HP:0004540)1.91291517
84B lymphocytopenia (HP:0010976)1.88364762
85Abnormality of B cell number (HP:0010975)1.88364762
86Asymmetry of the thorax (HP:0001555)1.88324471
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87740025
88Abnormal protein N-linked glycosylation (HP:0012347)1.87740025
89Abnormal protein glycosylation (HP:0012346)1.87740025
90Abnormal glycosylation (HP:0012345)1.87740025
91Abnormality of methionine metabolism (HP:0010901)1.86595643
92Absent septum pellucidum (HP:0001331)1.86566721
93Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86286022
94Deep philtrum (HP:0002002)1.86160259
95Abnormality of serum amino acid levels (HP:0003112)1.84679166
96Supernumerary spleens (HP:0009799)1.84666429
97Increased nuchal translucency (HP:0010880)1.84023087
98Horseshoe kidney (HP:0000085)1.83125688
99Hepatic necrosis (HP:0002605)1.82524137
100Pancreatic fibrosis (HP:0100732)1.82408028
101Cellular immunodeficiency (HP:0005374)1.81617574
102Abnormal number of incisors (HP:0011064)1.81391795
103Type 2 muscle fiber atrophy (HP:0003554)1.80752378
104Mesomelia (HP:0003027)1.79916179
105Abnormality of the septum pellucidum (HP:0007375)1.79638533
106Abnormality of DNA repair (HP:0003254)1.78835631
107Respiratory difficulties (HP:0002880)1.78142269
108Pendular nystagmus (HP:0012043)1.77639191
109Absent thumb (HP:0009777)1.77465860
110Increased serum lactate (HP:0002151)1.76773808
111Ovarian neoplasm (HP:0100615)1.75780280
112Microvesicular hepatic steatosis (HP:0001414)1.74512400
113Neoplasm of the adrenal gland (HP:0100631)1.73881204
114Abnormality of the carotid arteries (HP:0005344)1.73437334
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72350802
116Pancreatic cysts (HP:0001737)1.72250119
117Megaloblastic anemia (HP:0001889)1.71926771
118Abnormality of the calcaneus (HP:0008364)1.71735226
119Triphalangeal thumb (HP:0001199)1.71453174
120Combined immunodeficiency (HP:0005387)1.71415369
121Embryonal neoplasm (HP:0002898)1.71064257
122Missing ribs (HP:0000921)1.70988402
123Pancreatic islet-cell hyperplasia (HP:0004510)1.70692319
124Atresia of the external auditory canal (HP:0000413)1.69301330
125Small hand (HP:0200055)1.69254780
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.68697039
127Bilateral microphthalmos (HP:0007633)1.67951885
128Slender long bone (HP:0003100)1.67876818
129Abnormality of the pons (HP:0007361)1.67710223
130Hypoplasia of the pons (HP:0012110)1.67645186
131Microretrognathia (HP:0000308)1.67614459
132Agnosia (HP:0010524)1.67577247
133Molar tooth sign on MRI (HP:0002419)1.66402077
134Abnormality of midbrain morphology (HP:0002418)1.66402077
135Pallor (HP:0000980)1.66247291
136Gastrointestinal atresia (HP:0002589)1.65951641
137Abnormality of glycine metabolism (HP:0010895)1.65234288
138Abnormality of serine family amino acid metabolism (HP:0010894)1.65234288
139Carpal bone hypoplasia (HP:0001498)1.65195477
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64782879
141Acute lymphatic leukemia (HP:0006721)1.64771193
142Postnatal microcephaly (HP:0005484)1.64139935
143Muscle fiber atrophy (HP:0100295)1.64016516
144IgG deficiency (HP:0004315)1.63694735
145Neoplasm of the colon (HP:0100273)1.63583119
146Median cleft lip (HP:0000161)1.63423667
147Neoplasm of the pancreas (HP:0002894)1.63356446
148Leukodystrophy (HP:0002415)1.63280331
149Renal Fanconi syndrome (HP:0001994)1.62800572
150Hyperglycinuria (HP:0003108)1.61910705
151Dandy-Walker malformation (HP:0001305)1.61683070
152Abnormality of the incisor (HP:0000676)1.61570155
153Abnormality of the fingertips (HP:0001211)1.61019701
154Methylmalonic aciduria (HP:0012120)1.60929935
155Preaxial hand polydactyly (HP:0001177)1.59621133
156Increased serum pyruvate (HP:0003542)1.59076295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.82655771
2CDC73.69219016
3WEE13.57304502
4BRSK23.24143590
5VRK23.15637839
6MKNK13.10861419
7EIF2AK12.95096509
8CCNB12.90942693
9SRPK12.74894994
10MKNK22.45901799
11ACVR1B2.34048139
12VRK12.29596115
13BRSK12.06287799
14STK162.04038000
15PLK41.93026286
16PLK31.92117153
17TRIM281.90832730
18PASK1.90090436
19TSSK61.88697706
20CLK11.87643373
21CDK81.83613826
22TAF11.82182684
23PLK11.73316566
24ZAK1.71491310
25WNK31.71003246
26EIF2AK31.70043334
27TGFBR11.68020223
28ATR1.65030060
29PNCK1.62442940
30NEK21.61963377
31TNIK1.60603941
32TEC1.55794457
33TLK11.55289840
34TTK1.51588318
35AURKB1.49712353
36IRAK41.38303663
37CDK71.37920958
38ERBB31.36292046
39RPS6KA41.28142549
40SIK31.23228043
41BRD41.22555262
42BTK1.14423553
43NEK11.11794546
44MAP4K21.10676252
45NME21.10149153
46RPS6KB21.09078691
47EIF2AK21.06224446
48CHEK21.05098089
49STK41.04939126
50NME11.01941216
51DYRK20.96620933
52NEK90.94987521
53NUAK10.94214713
54MAP3K100.91972101
55YES10.91833350
56MAP3K140.89835094
57BMPR1B0.88704206
58TXK0.87504266
59CSNK1G10.85089048
60DYRK30.84424127
61KIT0.83323196
62CHEK10.82260362
63PIM20.82202115
64FRK0.81445426
65ATM0.78653689
66CSNK1G30.77811499
67AURKA0.75413734
68CSNK1G20.73167661
69PIM10.71453345
70RPS6KA60.70595468
71CSNK2A10.70368008
72RPS6KL10.67744123
73RPS6KC10.67744123
74STK30.65152243
75MAP4K10.64900756
76FLT30.64157644
77STK100.63828424
78MST40.61966738
79PAK40.61151234
80CDK40.60117824
81ALK0.60026303
82MINK10.57953574
83CDK20.57632351
84MAP3K40.57537280
85MELK0.57040814
86MAP3K80.56537708
87MAP2K30.56145739
88CDK10.55973077
89RPS6KB10.53839917
90CSNK2A20.51265125
91CSNK1A1L0.50784901
92TRPM70.50140208
93BCKDK0.49036668
94STK390.48537509
95RPS6KA50.47789528
96JAK30.47688546
97TIE10.47272196
98STK240.43698272
99CSNK1E0.41527503
100AKT30.40735140
101MAP3K120.40374842
102CHUK0.39596458
103MAP2K70.38850731
104MYLK0.37837365
105DAPK10.37677339
106BRAF0.37268616
107LYN0.37035448
108CDK60.36969936
109STK38L0.36960105
110OXSR10.36938175
111TESK20.36902936
112MAPK130.36714406
113PBK0.36439010
114CDK180.36342078
115CDK140.35943758
116PRKDC0.35197363
117SGK20.34354849
118CSF1R0.33628922
119PRKCG0.33613780
120INSRR0.33550539
121CDK30.33215253
122SCYL20.32142569
123ITK0.31706334
124UHMK10.31269024
125CDK150.30708856
126LATS10.30635944
127PLK20.30051341
128CASK0.29981991
129MAPKAPK20.29557429
130BCR0.29287104
131BMPR20.28514222
132SYK0.27991513
133CDK11A0.27909547
134KDR0.27073835
135ADRBK20.26774182
136FGFR10.26443511
137ILK0.25925712
138GRK10.25792843
139CSNK1D0.25121203
140ERBB40.23297022
141MAPKAPK50.22282236

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.40242649
2Mismatch repair_Homo sapiens_hsa034304.51846197
3Homologous recombination_Homo sapiens_hsa034403.57725641
4* Base excision repair_Homo sapiens_hsa034103.37090795
5Spliceosome_Homo sapiens_hsa030403.33033237
6Nucleotide excision repair_Homo sapiens_hsa034203.06884058
7Cell cycle_Homo sapiens_hsa041102.97620733
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90553412
9RNA polymerase_Homo sapiens_hsa030202.84419787
10Ribosome_Homo sapiens_hsa030102.75785881
11Proteasome_Homo sapiens_hsa030502.75168343
12Non-homologous end-joining_Homo sapiens_hsa034502.67064152
13Fanconi anemia pathway_Homo sapiens_hsa034602.56003634
14Pyrimidine metabolism_Homo sapiens_hsa002402.49532495
15RNA transport_Homo sapiens_hsa030132.47258884
16RNA degradation_Homo sapiens_hsa030182.26057772
17Basal transcription factors_Homo sapiens_hsa030222.07660875
18One carbon pool by folate_Homo sapiens_hsa006702.07093644
19Protein export_Homo sapiens_hsa030601.92176854
20mRNA surveillance pathway_Homo sapiens_hsa030151.66980849
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64810742
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61682160
23Propanoate metabolism_Homo sapiens_hsa006401.59634335
24p53 signaling pathway_Homo sapiens_hsa041151.54717258
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54624742
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49425380
27Purine metabolism_Homo sapiens_hsa002301.44289529
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33754933
29Pyruvate metabolism_Homo sapiens_hsa006201.23812624
30Steroid biosynthesis_Homo sapiens_hsa001001.13731630
31Systemic lupus erythematosus_Homo sapiens_hsa053221.13666127
32Herpes simplex infection_Homo sapiens_hsa051681.12422386
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09484520
34Epstein-Barr virus infection_Homo sapiens_hsa051691.05636032
35Alzheimers disease_Homo sapiens_hsa050101.03862227
36Primary immunodeficiency_Homo sapiens_hsa053401.02969129
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99385962
38Fatty acid elongation_Homo sapiens_hsa000620.97063798
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91377126
40Oocyte meiosis_Homo sapiens_hsa041140.85741049
41Antigen processing and presentation_Homo sapiens_hsa046120.84325824
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82106919
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81612098
44Viral carcinogenesis_Homo sapiens_hsa052030.80712650
45N-Glycan biosynthesis_Homo sapiens_hsa005100.79311690
46HTLV-I infection_Homo sapiens_hsa051660.76905470
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76422937
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75675669
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.74814582
50Legionellosis_Homo sapiens_hsa051340.74684611
51Measles_Homo sapiens_hsa051620.74012323
52Butanoate metabolism_Homo sapiens_hsa006500.73022700
53Thyroid cancer_Homo sapiens_hsa052160.71938772
54Biosynthesis of amino acids_Homo sapiens_hsa012300.70217260
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69992660
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67132229
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65770838
58Huntingtons disease_Homo sapiens_hsa050160.64302843
59Vitamin B6 metabolism_Homo sapiens_hsa007500.63485973
60Carbon metabolism_Homo sapiens_hsa012000.59902841
61Phototransduction_Homo sapiens_hsa047440.59030649
62Parkinsons disease_Homo sapiens_hsa050120.58810723
63Small cell lung cancer_Homo sapiens_hsa052220.58311897
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58268436
65MicroRNAs in cancer_Homo sapiens_hsa052060.56302246
66Hepatitis B_Homo sapiens_hsa051610.54042473
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.53058543
68Arachidonic acid metabolism_Homo sapiens_hsa005900.52655699
69Peroxisome_Homo sapiens_hsa041460.52476605
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.50918859
71Hematopoietic cell lineage_Homo sapiens_hsa046400.49283782
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48936432
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48909375
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47827321
75Glutathione metabolism_Homo sapiens_hsa004800.46082015
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45253291
77Nitrogen metabolism_Homo sapiens_hsa009100.43638332
78Alcoholism_Homo sapiens_hsa050340.42926182
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42732828
80Apoptosis_Homo sapiens_hsa042100.42669490
81Influenza A_Homo sapiens_hsa051640.42419980
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42361874
83Hedgehog signaling pathway_Homo sapiens_hsa043400.41607112
84Cardiac muscle contraction_Homo sapiens_hsa042600.39962846
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38988385
86Fatty acid metabolism_Homo sapiens_hsa012120.37652518
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36091718
88Selenocompound metabolism_Homo sapiens_hsa004500.34909630
89Allograft rejection_Homo sapiens_hsa053300.34380818
90Wnt signaling pathway_Homo sapiens_hsa043100.34240609
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33833048
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33704925
93Folate biosynthesis_Homo sapiens_hsa007900.33260613
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.32984320
95Shigellosis_Homo sapiens_hsa051310.32135859
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30531729
97Leishmaniasis_Homo sapiens_hsa051400.30346071
98Fatty acid degradation_Homo sapiens_hsa000710.29880214
99Pentose phosphate pathway_Homo sapiens_hsa000300.29825384
100beta-Alanine metabolism_Homo sapiens_hsa004100.29718955
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29646744
102Colorectal cancer_Homo sapiens_hsa052100.29131313
103Prostate cancer_Homo sapiens_hsa052150.27979239
104Tryptophan metabolism_Homo sapiens_hsa003800.27949227
105TGF-beta signaling pathway_Homo sapiens_hsa043500.27874032
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26884323
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26431847
108Chronic myeloid leukemia_Homo sapiens_hsa052200.26338730
109Asthma_Homo sapiens_hsa053100.26255185
110Vitamin digestion and absorption_Homo sapiens_hsa049770.25951638
111Sulfur relay system_Homo sapiens_hsa041220.25222644
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23365764
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23221020
114Pathways in cancer_Homo sapiens_hsa052000.22923257
115Viral myocarditis_Homo sapiens_hsa054160.22560497
116Lysine degradation_Homo sapiens_hsa003100.21247757
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21011511
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20095749
119Acute myeloid leukemia_Homo sapiens_hsa052210.20072405
120Non-small cell lung cancer_Homo sapiens_hsa052230.19828496
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.19433522
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.19034989
123Caffeine metabolism_Homo sapiens_hsa002320.18814698
124Basal cell carcinoma_Homo sapiens_hsa052170.18814355
125Olfactory transduction_Homo sapiens_hsa047400.18767651
126B cell receptor signaling pathway_Homo sapiens_hsa046620.18464266
127Oxidative phosphorylation_Homo sapiens_hsa001900.17199531
128Pancreatic cancer_Homo sapiens_hsa052120.16992381
129Hippo signaling pathway_Homo sapiens_hsa043900.16549687
130Metabolic pathways_Homo sapiens_hsa011000.15967122
131Regulation of autophagy_Homo sapiens_hsa041400.15892196
132Nicotine addiction_Homo sapiens_hsa050330.15765908
133Autoimmune thyroid disease_Homo sapiens_hsa053200.15717832
134Arginine and proline metabolism_Homo sapiens_hsa003300.15536373
135Retinol metabolism_Homo sapiens_hsa008300.14740986
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14480042
137Taste transduction_Homo sapiens_hsa047420.13698154
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13627236
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13077405
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12988502
141FoxO signaling pathway_Homo sapiens_hsa040680.12673295
142Graft-versus-host disease_Homo sapiens_hsa053320.12532341
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12249176
144Galactose metabolism_Homo sapiens_hsa000520.12127041
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12117009
146Melanoma_Homo sapiens_hsa052180.11550216
147Chemical carcinogenesis_Homo sapiens_hsa052040.09628289

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