HMGB1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.42620251
2cytidine metabolic process (GO:0046087)8.42620251
3cytidine catabolic process (GO:0006216)8.42620251
4DNA deamination (GO:0045006)8.31800694
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.04799193
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.28895820
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81647355
8ATP synthesis coupled proton transport (GO:0015986)4.57430473
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.57430473
10protein neddylation (GO:0045116)4.37224493
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16491766
12regulation of cellular amino acid metabolic process (GO:0006521)3.84947261
13respiratory electron transport chain (GO:0022904)3.82850844
14electron transport chain (GO:0022900)3.80267132
15pyrimidine nucleoside catabolic process (GO:0046135)3.78491832
16actin nucleation (GO:0045010)3.74978854
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72786454
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69506984
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63534899
20negative regulation by host of viral transcription (GO:0043922)3.61487096
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.59173501
22sequestering of actin monomers (GO:0042989)3.58239302
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53502907
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53502907
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53502907
26ribosomal small subunit assembly (GO:0000028)3.52560218
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51691386
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51691386
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44350096
30negative regulation of ligase activity (GO:0051352)3.40112121
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40112121
32protein complex biogenesis (GO:0070271)3.35161627
33positive regulation of interleukin-8 secretion (GO:2000484)3.34518091
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34214232
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.34214232
36chaperone-mediated protein transport (GO:0072321)3.34103801
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.31471891
38negative regulation of T cell apoptotic process (GO:0070233)3.28025106
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27356425
40water-soluble vitamin biosynthetic process (GO:0042364)3.25717596
41positive T cell selection (GO:0043368)3.25050785
42proteasome assembly (GO:0043248)3.23563263
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23282970
44regulation of chronic inflammatory response (GO:0002676)3.21302180
45DNA demethylation (GO:0080111)3.18559982
46positive thymic T cell selection (GO:0045059)3.18019206
47metallo-sulfur cluster assembly (GO:0031163)3.16111632
48iron-sulfur cluster assembly (GO:0016226)3.16111632
49negative regulation of viral genome replication (GO:0045071)3.15155233
50mitochondrial respiratory chain complex assembly (GO:0033108)3.11733416
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04044041
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02676652
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.02107596
54termination of RNA polymerase III transcription (GO:0006386)3.02107596
55positive regulation of B cell differentiation (GO:0045579)3.00963011
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98050085
57behavioral response to nicotine (GO:0035095)2.97985206
58positive regulation of defense response to virus by host (GO:0002230)2.97189091
59NADH dehydrogenase complex assembly (GO:0010257)2.95864892
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95864892
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.95864892
62regulation of activation of Janus kinase activity (GO:0010533)2.93289913
63pyrimidine-containing compound catabolic process (GO:0072529)2.92365370
64positive regulation of calcium-mediated signaling (GO:0050850)2.92188256
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91657463
66DNA dealkylation (GO:0035510)2.88970830
67negative T cell selection (GO:0043383)2.86533138
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86529817
69DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84594990
70positive regulation of cell cycle arrest (GO:0071158)2.83853718
71rRNA modification (GO:0000154)2.78181804
72positive regulation of ligase activity (GO:0051351)2.76943692
73cytolysis (GO:0019835)2.75748865
74cytochrome complex assembly (GO:0017004)2.75680458
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.75023084
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73728064
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73728064
78protein-cofactor linkage (GO:0018065)2.73379747
79regulation of cellular amine metabolic process (GO:0033238)2.72960376
80positive regulation of natural killer cell mediated immunity (GO:0002717)2.72682235
81regulation of regulatory T cell differentiation (GO:0045589)2.72587845
82pyrimidine ribonucleoside metabolic process (GO:0046131)2.71758715
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71027285
84platelet dense granule organization (GO:0060155)2.69345379
85regulation of interleukin-8 secretion (GO:2000482)2.69087098
86positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68532662
87positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.67194634
88hydrogen ion transmembrane transport (GO:1902600)2.66814751
89cellular response to interleukin-15 (GO:0071350)2.66318394
90T cell migration (GO:0072678)2.66154710
91response to interferon-beta (GO:0035456)2.64390400
92negative regulation of lymphocyte apoptotic process (GO:0070229)2.64149761
93eosinophil chemotaxis (GO:0048245)2.63770654
94respiratory chain complex IV assembly (GO:0008535)2.62777923
95macrophage chemotaxis (GO:0048246)2.61966493
96proton transport (GO:0015992)2.59746159
97negative regulation of telomere maintenance (GO:0032205)2.56717547
98mannosylation (GO:0097502)2.56537678
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56093362
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56029403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.60760058
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11698283
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.84295751
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.39376734
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.38481058
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23484279
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02110505
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83425835
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76994355
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70556541
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64069283
12VDR_22108803_ChIP-Seq_LS180_Human2.60051206
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48606981
14VDR_23849224_ChIP-Seq_CD4+_Human2.45733810
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.42923417
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.35879914
17ZNF274_21170338_ChIP-Seq_K562_Hela2.30683330
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22442085
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18415931
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10291018
21FOXP3_21729870_ChIP-Seq_TREG_Human2.03223973
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01014539
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.98859773
24ELK1_19687146_ChIP-ChIP_HELA_Human1.91910072
25EZH2_22144423_ChIP-Seq_EOC_Human1.89576007
26IGF1R_20145208_ChIP-Seq_DFB_Human1.73550053
27MYC_18940864_ChIP-ChIP_HL60_Human1.71021885
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65500623
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63294468
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59700796
31TP53_22573176_ChIP-Seq_HFKS_Human1.57503755
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.53558019
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.51565657
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50811169
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50605228
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49299300
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47337013
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.43435758
39MYB_26560356_Chip-Seq_TH2_Human1.42167835
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41039275
41GATA3_26560356_Chip-Seq_TH2_Human1.36128435
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.35656471
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33920157
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30203069
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28350369
46AR_20517297_ChIP-Seq_VCAP_Human1.27013085
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24245266
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23539341
49HTT_18923047_ChIP-ChIP_STHdh_Human1.22215574
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22118476
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21120445
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.21120445
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19675559
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.19537570
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18479891
56IRF1_19129219_ChIP-ChIP_H3396_Human1.16425444
57EWS_26573619_Chip-Seq_HEK293_Human1.16353718
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.16110926
59NCOR_22424771_ChIP-Seq_293T_Human1.15565386
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15138243
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14350415
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14119888
63NANOG_20526341_ChIP-Seq_ESCs_Human1.13192624
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13098369
65GATA3_27048872_Chip-Seq_THYMUS_Human1.12992107
66TAF2_19829295_ChIP-Seq_ESCs_Human1.11649063
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.11310493
68CIITA_25753668_ChIP-Seq_RAJI_Human1.09961108
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07987911
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07766788
71SOX2_19829295_ChIP-Seq_ESCs_Human1.06138670
72NANOG_19829295_ChIP-Seq_ESCs_Human1.06138670
73ER_23166858_ChIP-Seq_MCF-7_Human1.05682229
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05625290
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04739772
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04455393
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03619696
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03341544
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01303152
80GABP_19822575_ChIP-Seq_HepG2_Human1.00922480
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00830617
82ERA_21632823_ChIP-Seq_H3396_Human1.00651222
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99963362
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.98040884
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95966953
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95184996
87MYC_19829295_ChIP-Seq_ESCs_Human0.93784773
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93597174
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92887239
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91886956
91DCP1A_22483619_ChIP-Seq_HELA_Human0.91781039
92BCL6_27268052_Chip-Seq_Bcells_Human0.91570808
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91565985
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.90768120
95ERG_20517297_ChIP-Seq_VCAP_Human0.90600390
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90539884
97RBPJ_21746931_ChIP-Seq_IB4_Human0.88402623
98MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88189936
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87693450
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.87386013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.91501896
2MP0001873_stomach_inflammation2.83093774
3MP0004147_increased_porphyrin_level2.70571832
4MP0001835_abnormal_antigen_presentation2.65587752
5MP0003763_abnormal_thymus_physiology2.32556311
6MP0002102_abnormal_ear_morphology2.30142513
7MP0009785_altered_susceptibility_to2.25274793
8MP0008877_abnormal_DNA_methylation2.23247616
9MP0009333_abnormal_splenocyte_physiolog2.08359658
10MP0008875_abnormal_xenobiotic_pharmacok2.06705082
11MP0008872_abnormal_physiological_respon1.97628507
12MP0006072_abnormal_retinal_apoptosis1.93260615
13MP0002876_abnormal_thyroid_physiology1.92721801
14MP0002148_abnormal_hypersensitivity_rea1.90644596
15MP0002138_abnormal_hepatobiliary_system1.87469918
16MP0003786_premature_aging1.84676906
17MP0001800_abnormal_humoral_immune1.84393931
18MP0003011_delayed_dark_adaptation1.82724801
19MP0006292_abnormal_olfactory_placode1.80477979
20MP0002277_abnormal_respiratory_mucosa1.78359317
21MP0002166_altered_tumor_susceptibility1.75826442
22MP0005645_abnormal_hypothalamus_physiol1.75500900
23MP0005000_abnormal_immune_tolerance1.69066713
24MP0000685_abnormal_immune_system1.65785655
25MP0001919_abnormal_reproductive_system1.63241427
26MP0000372_irregular_coat_pigmentation1.62136826
27MP0001905_abnormal_dopamine_level1.57594086
28MP0002420_abnormal_adaptive_immunity1.57333118
29MP0003806_abnormal_nucleotide_metabolis1.55966723
30MP0005551_abnormal_eye_electrophysiolog1.54159301
31MP0002723_abnormal_immune_serum1.52933640
32MP0005646_abnormal_pituitary_gland1.52350259
33MP0003646_muscle_fatigue1.52300547
34MP0009379_abnormal_foot_pigmentation1.52253487
35MP0001819_abnormal_immune_cell1.51412032
36MP0002736_abnormal_nociception_after1.51334080
37MP0002006_tumorigenesis1.51000106
38MP0001485_abnormal_pinna_reflex1.49383074
39MP0005025_abnormal_response_to1.46499653
40MP0001968_abnormal_touch/_nociception1.42758052
41MP0003866_abnormal_defecation1.42502635
42MP0005387_immune_system_phenotype1.41882410
43MP0001790_abnormal_immune_system1.41882410
44MP0005389_reproductive_system_phenotype1.41517495
45MP0003787_abnormal_imprinting1.39546613
46MP0008995_early_reproductive_senescence1.37666507
47MP0003878_abnormal_ear_physiology1.37147623
48MP0005377_hearing/vestibular/ear_phenot1.37147623
49MP0005253_abnormal_eye_physiology1.33619939
50MP0005084_abnormal_gallbladder_morpholo1.31694084
51MP0002452_abnormal_antigen_presenting1.30548964
52MP0006082_CNS_inflammation1.27509515
53MP0004145_abnormal_muscle_electrophysio1.26634550
54MP0006036_abnormal_mitochondrial_physio1.26352776
55MP0002398_abnormal_bone_marrow1.21601115
56MP0000716_abnormal_immune_system1.20381690
57MP0001986_abnormal_taste_sensitivity1.19014124
58MP0005410_abnormal_fertilization1.18338860
59MP0000689_abnormal_spleen_morphology1.11232337
60MP0003693_abnormal_embryo_hatching1.11232091
61MP0003195_calcinosis1.11217282
62MP0002095_abnormal_skin_pigmentation1.09121139
63MP0002163_abnormal_gland_morphology1.08716191
64MP0008058_abnormal_DNA_repair1.07320879
65MP0005075_abnormal_melanosome_morpholog1.04861031
66MP0002405_respiratory_system_inflammati1.04685492
67MP0000703_abnormal_thymus_morphology1.03586482
68MP0002722_abnormal_immune_system1.01576484
69MP0001764_abnormal_homeostasis1.01293103
70MP0003718_maternal_effect0.96418815
71MP0001845_abnormal_inflammatory_respons0.96074962
72MP0006276_abnormal_autonomic_nervous0.95928937
73MP0001188_hyperpigmentation0.95801180
74MP0002429_abnormal_blood_cell0.95584816
75MP0002693_abnormal_pancreas_physiology0.94325804
76MP0002837_dystrophic_cardiac_calcinosis0.92454734
77MP0004142_abnormal_muscle_tone0.90949314
78MP0005636_abnormal_mineral_homeostasis0.90229085
79MP0002160_abnormal_reproductive_system0.89962864
80MP0006035_abnormal_mitochondrial_morpho0.89638533
81MP0004885_abnormal_endolymph0.88458401
82MP0003252_abnormal_bile_duct0.88432105
83MP0005464_abnormal_platelet_physiology0.86305204
84MP0005379_endocrine/exocrine_gland_phen0.84426191
85MP0002638_abnormal_pupillary_reflex0.84405852
86MP0010155_abnormal_intestine_physiology0.83466523
87MP0009764_decreased_sensitivity_to0.82709764
88MP0010094_abnormal_chromosome_stability0.81890997
89MP0002933_joint_inflammation0.80469544
90MP0001501_abnormal_sleep_pattern0.79264635
91MP0005167_abnormal_blood-brain_barrier0.77184685
92MP0001119_abnormal_female_reproductive0.76874715
93MP0004742_abnormal_vestibular_system0.76733297
94MP0009745_abnormal_behavioral_response0.76350979
95MP0000631_abnormal_neuroendocrine_gland0.75668974
96MP0001853_heart_inflammation0.74150506
97MP0003880_abnormal_central_pattern0.74064192
98MP0001765_abnormal_ion_homeostasis0.74022628
99MP0002272_abnormal_nervous_system0.71117133
100MP0000613_abnormal_salivary_gland0.70451629

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.56144911
2Aplastic anemia (HP:0001915)4.25227141
3Mitochondrial inheritance (HP:0001427)4.21988216
4Abnormal mitochondria in muscle tissue (HP:0008316)4.16135590
5Acute encephalopathy (HP:0006846)4.10468110
6Progressive macrocephaly (HP:0004481)3.74249622
7Increased CSF lactate (HP:0002490)3.73346807
8Hepatocellular necrosis (HP:0001404)3.64716470
9IgG deficiency (HP:0004315)3.62657983
10T lymphocytopenia (HP:0005403)3.49242890
11Abnormality of T cell number (HP:0011839)3.43364622
12Congenital stationary night blindness (HP:0007642)3.36978711
13Severe combined immunodeficiency (HP:0004430)3.31851376
14Hepatic necrosis (HP:0002605)3.31600758
15Elevated erythrocyte sedimentation rate (HP:0003565)3.23597397
16Cerebral edema (HP:0002181)3.23205643
17Hypoproteinemia (HP:0003075)3.08587522
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97056696
19Abnormality of B cell number (HP:0010975)2.93714558
20Abnormality of the prostate (HP:0008775)2.91007762
21Pancreatic cysts (HP:0001737)2.89629987
22Abolished electroretinogram (ERG) (HP:0000550)2.86951616
23Increased hepatocellular lipid droplets (HP:0006565)2.85855996
24Molar tooth sign on MRI (HP:0002419)2.84893227
25Abnormality of midbrain morphology (HP:0002418)2.84893227
263-Methylglutaconic aciduria (HP:0003535)2.76842443
27Optic disc pallor (HP:0000543)2.75409122
28Abnormality of T cells (HP:0002843)2.74150226
29Renal Fanconi syndrome (HP:0001994)2.73840535
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72964766
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72964766
32Autoimmune hemolytic anemia (HP:0001890)2.72246057
33Type 2 muscle fiber atrophy (HP:0003554)2.64772245
34Lipid accumulation in hepatocytes (HP:0006561)2.63938317
35Combined immunodeficiency (HP:0005387)2.63833562
36Pancytopenia (HP:0001876)2.61813906
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61223714
38Increased intramyocellular lipid droplets (HP:0012240)2.60653541
39Increased serum lactate (HP:0002151)2.59359506
40Pancreatic fibrosis (HP:0100732)2.58528396
41B lymphocytopenia (HP:0010976)2.55472281
42Stomatitis (HP:0010280)2.55307951
43Attenuation of retinal blood vessels (HP:0007843)2.53560214
44Thyroiditis (HP:0100646)2.53014307
45Increased IgM level (HP:0003496)2.50242298
46Lactic acidosis (HP:0003128)2.45359871
47Lethargy (HP:0001254)2.43628968
48Abnormal rod and cone electroretinograms (HP:0008323)2.42939621
49True hermaphroditism (HP:0010459)2.36444811
50Pendular nystagmus (HP:0012043)2.36063982
51Decreased central vision (HP:0007663)2.27910336
52Muscle fiber atrophy (HP:0100295)2.26737492
53Abnormality of eosinophils (HP:0001879)2.24041719
54Methylmalonic acidemia (HP:0002912)2.23124414
55Type I transferrin isoform profile (HP:0003642)2.17218327
56Nephronophthisis (HP:0000090)2.15960282
57Agammaglobulinemia (HP:0004432)2.15410358
58Panhypogammaglobulinemia (HP:0003139)2.13984864
59Increased muscle lipid content (HP:0009058)2.13463056
60Respiratory failure (HP:0002878)2.13128768
61Methylmalonic aciduria (HP:0012120)2.07976920
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.06498898
63Absent thumb (HP:0009777)2.04872244
64Hyperglycinemia (HP:0002154)1.99153258
65Exercise intolerance (HP:0003546)1.94686741
66Recurrent cutaneous fungal infections (HP:0011370)1.94236892
67Chronic mucocutaneous candidiasis (HP:0002728)1.94236892
68Abnormal number of erythroid precursors (HP:0012131)1.93813231
69Cerebral palsy (HP:0100021)1.93089984
70Constricted visual fields (HP:0001133)1.92883241
71Chronic diarrhea (HP:0002028)1.92472058
72Abnormality of the renal cortex (HP:0011035)1.91341412
73Congenital, generalized hypertrichosis (HP:0004540)1.90740421
74Abnormality of cells of the erythroid lineage (HP:0012130)1.90158074
75Leukodystrophy (HP:0002415)1.89349092
76Exertional dyspnea (HP:0002875)1.89180003
77Encephalitis (HP:0002383)1.84884905
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82412584
79Eosinophilia (HP:0001880)1.78732357
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78656642
81Hypoalbuminemia (HP:0003073)1.78433162
82Abnormal albumin level (HP:0012116)1.78433162
83Abnormality of T cell physiology (HP:0011840)1.78311891
84Reticulocytopenia (HP:0001896)1.78157510
85Abnormality of the renal medulla (HP:0100957)1.78151616
86Autoimmune thrombocytopenia (HP:0001973)1.76711561
87Ketosis (HP:0001946)1.75820893
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74567609
89Abnormal protein N-linked glycosylation (HP:0012347)1.74567609
90Abnormal protein glycosylation (HP:0012346)1.74567609
91Abnormal glycosylation (HP:0012345)1.74567609
92Abnormal drinking behavior (HP:0030082)1.72336578
93Polydipsia (HP:0001959)1.72336578
94Prostate neoplasm (HP:0100787)1.71355537
95Severe visual impairment (HP:0001141)1.71304661
96Dicarboxylic aciduria (HP:0003215)1.70700884
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70700884
98Medial flaring of the eyebrow (HP:0010747)1.70356885
99Colon cancer (HP:0003003)1.70064218
100Oral leukoplakia (HP:0002745)1.69086465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.72810100
2TESK24.04766344
3KDR3.72370134
4TAOK33.05467608
5BCKDK2.96931805
6ZAK2.93199305
7VRK22.68133852
8TLK12.60775762
9MST42.40403632
10GRK12.32751304
11TIE12.29995858
12BUB12.29917840
13MAP4K22.22858581
14ADRBK22.15283556
15NUAK12.08205250
16MAP4K11.99306910
17WNK41.80881854
18BMPR1B1.75237374
19ITK1.74856182
20VRK11.68227433
21LIMK11.56020766
22TEC1.55285672
23STK161.52917896
24FRK1.32123176
25MAP3K121.22955382
26TESK11.18640018
27EIF2AK31.18534992
28FES1.18071153
29SYK1.15343742
30PINK11.14022448
31CDK191.11888735
32MAPKAPK31.11562642
33NME11.07366289
34PRKCQ0.99841712
35KIT0.90868648
36MUSK0.88340640
37BTK0.83400571
38TAF10.82582962
39GRK70.82207354
40CSNK1G10.82187953
41WNK30.81930566
42OXSR10.81812647
43CDC70.81639067
44TNK20.79740819
45MAP3K110.79194804
46CSNK1G30.78946608
47STK390.78643664
48LCK0.77441634
49MAPK130.76208685
50IKBKB0.71190226
51CSF1R0.70841325
52DYRK20.70469235
53SRPK10.70332867
54DAPK10.70143059
55AURKA0.69210607
56SCYL20.67251560
57INSRR0.67037243
58PLK40.64200744
59RPS6KA50.63377044
60TRIM280.62872661
61LYN0.62533957
62MKNK20.62303132
63CSNK1G20.57006136
64CDK80.55736381
65MYLK0.52344333
66MKNK10.51831847
67PIK3CA0.50916263
68GRK60.50802518
69EIF2AK20.50168399
70CSK0.49941659
71PLK30.49184498
72ADRBK10.48711253
73ATR0.47249214
74IKBKE0.46919693
75PLK10.46661241
76CSNK1A1L0.45048510
77MATK0.44802018
78AURKB0.43943592
79PHKG10.43176497
80PHKG20.43176497
81PLK20.41378646
82PASK0.40543870
83PIK3CG0.39488781
84IGF1R0.39131106
85CSNK2A10.39111041
86RPS6KA40.38961108
87OBSCN0.36721896
88PRKCA0.36483223
89PRKACA0.35099504
90PIM20.35090158
91MAP2K60.34835516
92CAMKK20.34178701
93PIM10.33033414
94CSNK2A20.32865437
95BCR0.31953368
96NEK10.30800034
97PRKCG0.29850997
98CAMK2A0.28426565
99ROCK10.27799376
100EIF2AK10.27512239

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.95429558
2Primary immunodeficiency_Homo sapiens_hsa053403.93396227
3Oxidative phosphorylation_Homo sapiens_hsa001903.64499964
4Parkinsons disease_Homo sapiens_hsa050123.21782238
5RNA polymerase_Homo sapiens_hsa030202.66246897
6Ribosome_Homo sapiens_hsa030102.65025199
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23302574
8Autoimmune thyroid disease_Homo sapiens_hsa053202.13452382
9Protein export_Homo sapiens_hsa030602.12777316
10Alzheimers disease_Homo sapiens_hsa050102.10143346
11Graft-versus-host disease_Homo sapiens_hsa053322.01172318
12Homologous recombination_Homo sapiens_hsa034401.99425059
13Allograft rejection_Homo sapiens_hsa053301.99080381
14Huntingtons disease_Homo sapiens_hsa050161.94862515
15Antigen processing and presentation_Homo sapiens_hsa046121.87549253
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80604567
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79275371
18Phototransduction_Homo sapiens_hsa047441.62086085
19Hematopoietic cell lineage_Homo sapiens_hsa046401.56813452
20Asthma_Homo sapiens_hsa053101.53603148
21Type I diabetes mellitus_Homo sapiens_hsa049401.53546580
22Mismatch repair_Homo sapiens_hsa034301.42018051
23Cardiac muscle contraction_Homo sapiens_hsa042601.41412892
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40830015
25DNA replication_Homo sapiens_hsa030301.35466464
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.35366798
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34301683
28Nitrogen metabolism_Homo sapiens_hsa009101.33680960
29Pyrimidine metabolism_Homo sapiens_hsa002401.32286726
30Linoleic acid metabolism_Homo sapiens_hsa005911.31391572
31Fanconi anemia pathway_Homo sapiens_hsa034601.30843302
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30317751
33T cell receptor signaling pathway_Homo sapiens_hsa046601.27085830
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26314182
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26165697
36Propanoate metabolism_Homo sapiens_hsa006401.22928449
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20217822
38Rheumatoid arthritis_Homo sapiens_hsa053231.15917379
39Peroxisome_Homo sapiens_hsa041461.13875099
40Nucleotide excision repair_Homo sapiens_hsa034201.08463248
41One carbon pool by folate_Homo sapiens_hsa006701.04279346
42Purine metabolism_Homo sapiens_hsa002301.03708828
43RNA degradation_Homo sapiens_hsa030181.03183674
44Butanoate metabolism_Homo sapiens_hsa006501.01690852
45Base excision repair_Homo sapiens_hsa034100.99816813
46Spliceosome_Homo sapiens_hsa030400.95209608
47Caffeine metabolism_Homo sapiens_hsa002320.94854644
48Basal transcription factors_Homo sapiens_hsa030220.94452489
49Systemic lupus erythematosus_Homo sapiens_hsa053220.94357545
50Tryptophan metabolism_Homo sapiens_hsa003800.93736326
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92391111
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.81146712
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80375752
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79273838
55Non-homologous end-joining_Homo sapiens_hsa034500.77435348
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76767747
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73959717
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71620952
59Fatty acid elongation_Homo sapiens_hsa000620.68675266
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68486804
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63906604
62Chemical carcinogenesis_Homo sapiens_hsa052040.62217558
63Olfactory transduction_Homo sapiens_hsa047400.60435687
64Metabolic pathways_Homo sapiens_hsa011000.60091387
65Selenocompound metabolism_Homo sapiens_hsa004500.60080775
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.56877949
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56150929
68Retinol metabolism_Homo sapiens_hsa008300.55353843
69Ether lipid metabolism_Homo sapiens_hsa005650.55290708
70RNA transport_Homo sapiens_hsa030130.54727517
71Arachidonic acid metabolism_Homo sapiens_hsa005900.53769396
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.52820883
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51899699
74Measles_Homo sapiens_hsa051620.50264224
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.49771175
76Fat digestion and absorption_Homo sapiens_hsa049750.49727931
77Viral myocarditis_Homo sapiens_hsa054160.48055124
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46996956
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45817002
80Sulfur metabolism_Homo sapiens_hsa009200.44542821
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39962232
82Folate biosynthesis_Homo sapiens_hsa007900.39009933
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39000860
84Collecting duct acid secretion_Homo sapiens_hsa049660.38844794
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.38710349
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35786537
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32791110
88Sulfur relay system_Homo sapiens_hsa041220.31784622
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31204603
90Fatty acid degradation_Homo sapiens_hsa000710.30182032
91Epstein-Barr virus infection_Homo sapiens_hsa051690.29521526
92Glutathione metabolism_Homo sapiens_hsa004800.29146417
93Pyruvate metabolism_Homo sapiens_hsa006200.28124731
94Regulation of autophagy_Homo sapiens_hsa041400.27806811
95Steroid biosynthesis_Homo sapiens_hsa001000.27702011
96beta-Alanine metabolism_Homo sapiens_hsa004100.26748965
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.26351058
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24318951
99Taste transduction_Homo sapiens_hsa047420.24262723
100Alcoholism_Homo sapiens_hsa050340.22923851

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