ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.06583897
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.22925057
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.01217477
4	ATP synthesis coupled proton transport (GO:0015986)	5.01217477
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.93894628
6	ribosomal small subunit assembly (GO:0000028)	4.85594855
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.62184236
8	cytidine deamination (GO:0009972)	4.38123666
9	cytidine metabolic process (GO:0046087)	4.38123666
10	cytidine catabolic process (GO:0006216)	4.38123666
11	chaperone-mediated protein transport (GO:0072321)	4.30187104
12	protein complex biogenesis (GO:0070271)	4.24817738
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.23288933
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.23288933
15	behavioral response to nicotine (GO:0035095)	4.14671997
16	protein neddylation (GO:0045116)	4.11342112
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.10670474
18	NADH dehydrogenase complex assembly (GO:0010257)	4.10670474
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.10670474
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.09825823
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.86503288
22	respiratory electron transport chain (GO:0022904)	3.81039358
23	electron transport chain (GO:0022900)	3.80158703
24	negative regulation of telomere maintenance (GO:0032205)	3.79426521
25	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.67922946
26	chromatin remodeling at centromere (GO:0031055)	3.61135060
27	maturation of SSU-rRNA (GO:0030490)	3.53775427
28	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.50883399
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.49979927
30	mannosylation (GO:0097502)	3.45966045
31	protein-cofactor linkage (GO:0018065)	3.41019576
32	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.39019824
33	CENP-A containing nucleosome assembly (GO:0034080)	3.32158770
34	adenosine metabolic process (GO:0046085)	3.30630537
35	viral transcription (GO:0019083)	3.26566838
36	respiratory chain complex IV assembly (GO:0008535)	3.25882877
37	translational termination (GO:0006415)	3.17410589
38	regulation of cellular amino acid metabolic process (GO:0006521)	3.14971975
39	GTP biosynthetic process (GO:0006183)	3.13411758
40	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.07907324
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.07793853
42	termination of RNA polymerase III transcription (GO:0006386)	3.07793853
43	cotranslational protein targeting to membrane (GO:0006613)	3.06270516
44	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.05106579
45	positive regulation of protein homodimerization activity (GO:0090073)	3.04273508
46	protein targeting to ER (GO:0045047)	3.02841916
47	sequestering of actin monomers (GO:0042989)	3.01151016
48	translational elongation (GO:0006414)	2.98510941
49	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.97662000
50	cytochrome complex assembly (GO:0017004)	2.95940515
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.95316094
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.95316094
53	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.95316094
54	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.93179811
55	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.93179811
56	platelet dense granule organization (GO:0060155)	2.91691232
57	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.89225960
58	protein localization to endoplasmic reticulum (GO:0070972)	2.87404146
59	maturation of 5.8S rRNA (GO:0000460)	2.85915797
60	cell proliferation in forebrain (GO:0021846)	2.85282575
61	hydrogen ion transmembrane transport (GO:1902600)	2.81492127
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.81013467
63	iron-sulfur cluster assembly (GO:0016226)	2.79160814
64	metallo-sulfur cluster assembly (GO:0031163)	2.79160814
65	cellular component biogenesis (GO:0044085)	2.78543000
66	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.76530967
67	tRNA processing (GO:0008033)	2.76404573
68	translation (GO:0006412)	2.76224698
69	indole-containing compound catabolic process (GO:0042436)	2.76002043
70	indolalkylamine catabolic process (GO:0046218)	2.76002043
71	tryptophan catabolic process (GO:0006569)	2.76002043
72	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.75284919
73	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.75284919
74	rRNA catabolic process (GO:0016075)	2.75076554
75	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74781431
76	protein K6-linked ubiquitination (GO:0085020)	2.74482263
77	ribosomal small subunit biogenesis (GO:0042274)	2.71803807
78	histone exchange (GO:0043486)	2.71529474
79	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71502745
80	proton transport (GO:0015992)	2.71045104
81	rRNA processing (GO:0006364)	2.70926825
82	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.70817277
83	negative regulation of ligase activity (GO:0051352)	2.70817277
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.70473506
85	aldehyde catabolic process (GO:0046185)	2.69595476
86	rRNA modification (GO:0000154)	2.69106749
87	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.69014911
88	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68653041
89	rRNA metabolic process (GO:0016072)	2.67221982
90	purine nucleotide salvage (GO:0032261)	2.65913409
91	folic acid-containing compound biosynthetic process (GO:0009396)	2.65523047
92	hydrogen transport (GO:0006818)	2.63597051
93	ATP biosynthetic process (GO:0006754)	2.62582381
94	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.60747561
95	ubiquinone biosynthetic process (GO:0006744)	2.60674024
96	telomere maintenance via semi-conservative replication (GO:0032201)	2.60543588
97	axoneme assembly (GO:0035082)	2.59125308
98	DNA replication checkpoint (GO:0000076)	2.57964019
99	cellular ketone body metabolic process (GO:0046950)	2.57329386
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.56852081

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.51401963
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.32806985
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.12138238
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.65660587
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.35255596
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00562090
7	VDR_22108803_ChIP-Seq_LS180_Human	2.96022700
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83270345
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.82194327
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.73852317
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.66170424
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.41661688
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38617785
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34700015
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.30410574
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.23419816
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.17212118
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15813198
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.11556756
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.09882697
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.08150550
22	MYC_18940864_ChIP-ChIP_HL60_Human	2.06647210
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.05513074
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.94370780
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.91562761
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.91337123
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71136266
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.70884179
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67799650
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66641405
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.63163764
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55895587
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.54586577
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52780856
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52458518
36	EWS_26573619_Chip-Seq_HEK293_Human	1.46650649
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42736923
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.39832083
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38867476
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.33507638
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27948867
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27582065
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.25706697
44	NCOR_22424771_ChIP-Seq_293T_Human	1.25448073
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25171993
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25171993
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23757461
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.21275573
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18994032
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18414895
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17457955
52	AR_20517297_ChIP-Seq_VCAP_Human	1.17374948
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.16868286
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13535420
55	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.13502900
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13486146
57	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11012316
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10251544
59	IGF1R_20145208_ChIP-Seq_DFB_Human	1.09561058
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.09492321
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07282910
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07056637
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05915591
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05819478
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.04711911
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03988158
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03988158
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03370468
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03320471
70	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01567233
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01105951
72	P300_19829295_ChIP-Seq_ESCs_Human	0.99938507
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98580681
74	ERA_21632823_ChIP-Seq_H3396_Human	0.96896843
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96648782
76	FUS_26573619_Chip-Seq_HEK293_Human	0.94606509
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93820023
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92708445
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91959409
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91104121
81	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90622521
82	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.90401994
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.90250526
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89102561
85	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.89088594
86	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88882454
87	GATA3_26560356_Chip-Seq_TH2_Human	0.88722141
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.87689279
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87591289
90	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.87066583
91	GBX2_23144817_ChIP-Seq_PC3_Human	0.83812914
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.83668077
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.83442467
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.82734334
95	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82439229
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.82096132
97	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.81741467
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.81527283
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.81450680
100	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.81450680

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.59931062
2	MP0008877_abnormal_DNA_methylation	3.33927693
3	MP0009379_abnormal_foot_pigmentation	2.90256560
4	MP0002102_abnormal_ear_morphology	2.86611135
5	MP0001348_abnormal_lacrimal_gland	2.60143645
6	MP0005671_abnormal_response_to	2.57030295
7	MP0004147_increased_porphyrin_level	2.52815131
8	MP0005646_abnormal_pituitary_gland	2.43482931
9	MP0005360_urolithiasis	2.21318131
10	MP0008872_abnormal_physiological_respon	2.19017130
11	MP0003646_muscle_fatigue	2.18434902
12	MP0002163_abnormal_gland_morphology	2.17617468
13	MP0003693_abnormal_embryo_hatching	2.14712724
14	MP0005377_hearing/vestibular/ear_phenot	2.11379536
15	MP0003878_abnormal_ear_physiology	2.11379536
16	MP0002138_abnormal_hepatobiliary_system	2.07958409
17	MP0002736_abnormal_nociception_after	1.97686103
18	MP0003806_abnormal_nucleotide_metabolis	1.91106246
19	MP0002837_dystrophic_cardiac_calcinosis	1.82385212
20	MP0004142_abnormal_muscle_tone	1.79250667
21	MP0001293_anophthalmia	1.78752178
22	MP0008789_abnormal_olfactory_epithelium	1.77507722
23	MP0005379_endocrine/exocrine_gland_phen	1.71241903
24	MP0001905_abnormal_dopamine_level	1.60407028
25	MP0005551_abnormal_eye_electrophysiolog	1.60104028
26	MP0004885_abnormal_endolymph	1.57437063
27	MP0002938_white_spotting	1.56096556
28	MP0008058_abnormal_DNA_repair	1.54915319
29	MP0003787_abnormal_imprinting	1.52449578
30	MP0001485_abnormal_pinna_reflex	1.51911703
31	MP0002653_abnormal_ependyma_morphology	1.44457442
32	MP0001968_abnormal_touch/_nociception	1.42318406
33	MP0002095_abnormal_skin_pigmentation	1.38737194
34	MP0004145_abnormal_muscle_electrophysio	1.38254526
35	MP0006072_abnormal_retinal_apoptosis	1.38209778
36	MP0008995_early_reproductive_senescence	1.37706180
37	MP0002272_abnormal_nervous_system	1.28101136
38	MP0003786_premature_aging	1.26314895
39	MP0005084_abnormal_gallbladder_morpholo	1.25813122
40	MP0001529_abnormal_vocalization	1.25447658
41	MP0002876_abnormal_thyroid_physiology	1.24244779
42	MP0006276_abnormal_autonomic_nervous	1.22079720
43	MP0003880_abnormal_central_pattern	1.20154616
44	MP0000372_irregular_coat_pigmentation	1.18547323
45	MP0001986_abnormal_taste_sensitivity	1.17888572
46	MP0004043_abnormal_pH_regulation	1.17871227
47	MP0005499_abnormal_olfactory_system	1.16379035
48	MP0005394_taste/olfaction_phenotype	1.16379035
49	MP0008875_abnormal_xenobiotic_pharmacok	1.16271382
50	MP0005253_abnormal_eye_physiology	1.14345127
51	MP0005645_abnormal_hypothalamus_physiol	1.11666096
52	MP0009046_muscle_twitch	1.10984662
53	MP0001984_abnormal_olfaction	1.09740731
54	MP0005075_abnormal_melanosome_morpholog	1.09099282
55	MP0006036_abnormal_mitochondrial_physio	1.08957624
56	MP0002822_catalepsy	1.07758852
57	MP0009333_abnormal_splenocyte_physiolog	1.07110719
58	MP0010094_abnormal_chromosome_stability	1.06711383
59	MP0000049_abnormal_middle_ear	1.05877019
60	MP0009785_altered_susceptibility_to	0.99930609
61	MP0002006_tumorigenesis	0.99024727
62	MP0003718_maternal_effect	0.96477988
63	MP0002210_abnormal_sex_determination	0.95794510
64	MP0000026_abnormal_inner_ear	0.95765853
65	MP0000631_abnormal_neuroendocrine_gland	0.95592572
66	MP0009745_abnormal_behavioral_response	0.94937945
67	MP0002277_abnormal_respiratory_mucosa	0.94847562
68	MP0001764_abnormal_homeostasis	0.94101345
69	MP0002638_abnormal_pupillary_reflex	0.91595949
70	MP0003252_abnormal_bile_duct	0.90771965
71	MP0005423_abnormal_somatic_nervous	0.90581624
72	MP0003186_abnormal_redox_activity	0.88532856
73	MP0001919_abnormal_reproductive_system	0.88436554
74	MP0002166_altered_tumor_susceptibility	0.87413972
75	MP0005636_abnormal_mineral_homeostasis	0.87247581
76	MP0005195_abnormal_posterior_eye	0.86227129
77	MP0003195_calcinosis	0.85626488
78	MP0010030_abnormal_orbit_morphology	0.84285843
79	MP0001970_abnormal_pain_threshold	0.84219589
80	MP0004742_abnormal_vestibular_system	0.83723055
81	MP0005389_reproductive_system_phenotype	0.83203654
82	MP0003567_abnormal_fetal_cardiomyocyte	0.82023941
83	MP0000685_abnormal_immune_system	0.80703273
84	MP0002233_abnormal_nose_morphology	0.80407439
85	MP0001835_abnormal_antigen_presentation	0.79622300
86	MP0001929_abnormal_gametogenesis	0.79252722
87	MP0004133_heterotaxia	0.78266761
88	MP0009764_decreased_sensitivity_to	0.78208607
89	MP0002733_abnormal_thermal_nociception	0.78165508
90	MP0003121_genomic_imprinting	0.77838036
91	MP0003011_delayed_dark_adaptation	0.77545473
92	MP0003937_abnormal_limbs/digits/tail_de	0.77199989
93	MP0003938_abnormal_ear_development	0.76416993
94	MP0000653_abnormal_sex_gland	0.75656708
95	MP0001119_abnormal_female_reproductive	0.75433490
96	MP0001486_abnormal_startle_reflex	0.72846889
97	MP0000613_abnormal_salivary_gland	0.72677145
98	MP0001145_abnormal_male_reproductive	0.71845504
99	MP0001790_abnormal_immune_system	0.70798916
100	MP0005387_immune_system_phenotype	0.70798916

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.29381110
2	Abnormal mitochondria in muscle tissue (HP:0008316)	3.85463281
3	Mitochondrial inheritance (HP:0001427)	3.62507643
4	Abnormality of alanine metabolism (HP:0010916)	3.57577656
5	Hyperalaninemia (HP:0003348)	3.57577656
6	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.57577656
7	Acute encephalopathy (HP:0006846)	3.56042720
8	Progressive macrocephaly (HP:0004481)	3.49491626
9	Increased CSF lactate (HP:0002490)	3.35819377
10	Reticulocytopenia (HP:0001896)	3.23474307
11	Molar tooth sign on MRI (HP:0002419)	3.10926733
12	Abnormality of midbrain morphology (HP:0002418)	3.10926733
13	Pancreatic cysts (HP:0001737)	2.94027962
14	Hepatocellular necrosis (HP:0001404)	2.85790376
15	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.85253549
16	Increased hepatocellular lipid droplets (HP:0006565)	2.82084351
17	Aplastic anemia (HP:0001915)	2.82078074
18	Pancreatic fibrosis (HP:0100732)	2.81704689
19	Congenital stationary night blindness (HP:0007642)	2.79693562
20	IgG deficiency (HP:0004315)	2.76263006
21	Constricted visual fields (HP:0001133)	2.74740363
22	Type II lissencephaly (HP:0007260)	2.69587466
23	Methylmalonic acidemia (HP:0002912)	2.69261606
24	Abnormality of the labia minora (HP:0012880)	2.68069833
25	Methylmalonic aciduria (HP:0012120)	2.67283600
26	Hepatic necrosis (HP:0002605)	2.64504991
27	Cerebral edema (HP:0002181)	2.63502008
28	Increased serum lactate (HP:0002151)	2.61905712
29	Type I transferrin isoform profile (HP:0003642)	2.59060315
30	Rib fusion (HP:0000902)	2.58848950
31	Birth length less than 3rd percentile (HP:0003561)	2.53009317
32	Renal Fanconi syndrome (HP:0001994)	2.45167942
33	Increased intramyocellular lipid droplets (HP:0012240)	2.44190731
34	Lipid accumulation in hepatocytes (HP:0006561)	2.40903675
35	Absent thumb (HP:0009777)	2.40894536
36	Abolished electroretinogram (ERG) (HP:0000550)	2.37553794
37	Pendular nystagmus (HP:0012043)	2.37000765
38	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.33214526
39	Optic disc pallor (HP:0000543)	2.32603173
40	Sclerocornea (HP:0000647)	2.30617337
41	Chromsome breakage (HP:0040012)	2.27269326
42	Hypoproteinemia (HP:0003075)	2.26813556
43	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.25460649
44	True hermaphroditism (HP:0010459)	2.24067195
45	Lactic acidosis (HP:0003128)	2.23680229
46	Abnormality of the pons (HP:0007361)	2.22157004
47	Abnormal drinking behavior (HP:0030082)	2.20113684
48	Polydipsia (HP:0001959)	2.20113684
49	Macrocytic anemia (HP:0001972)	2.19596756
50	Anophthalmia (HP:0000528)	2.17197685
51	Elevated erythrocyte sedimentation rate (HP:0003565)	2.15267097
52	Pancytopenia (HP:0001876)	2.13909138
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.12559252
54	Hypoplasia of the pons (HP:0012110)	2.12401103
55	Abnormality of the renal collecting system (HP:0004742)	2.12238601
56	Congenital, generalized hypertrichosis (HP:0004540)	2.08352517
57	Abnormality of the renal cortex (HP:0011035)	2.07880394
58	Lethargy (HP:0001254)	2.07663766
59	Nephronophthisis (HP:0000090)	2.07640455
60	Septo-optic dysplasia (HP:0100842)	2.06657293
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00363532
62	Abnormal rod and cone electroretinograms (HP:0008323)	2.00240344
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99997998
64	Reduced antithrombin III activity (HP:0001976)	1.99990811
65	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.99581052
66	Abnormality of DNA repair (HP:0003254)	1.99490185
67	3-Methylglutaconic aciduria (HP:0003535)	1.99435025
68	Small hand (HP:0200055)	1.98992227
69	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.98262140
70	Hyperglycinemia (HP:0002154)	1.96700815
71	Chronic hepatic failure (HP:0100626)	1.96523472
72	Medial flaring of the eyebrow (HP:0010747)	1.96359030
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.94718281
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.94718281
75	Abnormal protein glycosylation (HP:0012346)	1.94718281
76	Abnormal glycosylation (HP:0012345)	1.94718281
77	Cystic liver disease (HP:0006706)	1.93005339
78	Abnormality of the ileum (HP:0001549)	1.92536589
79	Parakeratosis (HP:0001036)	1.91920132
80	Abnormality of serum amino acid levels (HP:0003112)	1.91517504
81	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.89539270
82	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.89539270
83	Tubular atrophy (HP:0000092)	1.89144564
84	Abnormal number of erythroid precursors (HP:0012131)	1.88787448
85	Leukodystrophy (HP:0002415)	1.88762012
86	Absent septum pellucidum (HP:0001331)	1.88691776
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.88502065
88	Supernumerary spleens (HP:0009799)	1.88367855
89	Meckel diverticulum (HP:0002245)	1.85994759
90	Polyuria (HP:0000103)	1.85630385
91	Lissencephaly (HP:0001339)	1.84844693
92	Severe muscular hypotonia (HP:0006829)	1.82812333
93	Colon cancer (HP:0003003)	1.82493335
94	Ectopic kidney (HP:0000086)	1.82269535
95	Hypomagnesemia (HP:0002917)	1.81704726
96	Cerebellar dysplasia (HP:0007033)	1.81391532
97	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.80505681
98	Optic nerve hypoplasia (HP:0000609)	1.80302049
99	Exertional dyspnea (HP:0002875)	1.80298404
100	Anencephaly (HP:0002323)	1.80221186

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.14479334
2	ZAK	2.95508750
3	VRK2	2.65356771
4	MAP3K12	2.57861147
5	TXK	2.55794040
6	BCKDK	2.31200749
7	WNK4	2.26913085
8	TAOK3	2.25261329
9	ADRBK2	2.11771078
10	PINK1	2.10839448
11	CDC7	2.09533574
12	TLK1	2.02942839
13	MST4	1.98168053
14	KDR	1.94553824
15	FRK	1.93784081
16	BUB1	1.88091547
17	EPHB2	1.81547807
18	MUSK	1.79172771
19	GRK1	1.69027919
20	VRK1	1.64254259
21	BMPR1B	1.61933398
22	EIF2AK1	1.57107584
23	STK39	1.45136291
24	NUAK1	1.43961377
25	DYRK2	1.36952310
26	MAP4K2	1.36033800
27	NME1	1.35057748
28	TIE1	1.34380606
29	CDK19	1.31405335
30	EIF2AK3	1.27274765
31	WEE1	1.25676885
32	OXSR1	1.24441575
33	BRSK2	1.24135426
34	LIMK1	1.20728233
35	PLK3	1.11991684
36	MKNK2	1.11921688
37	NLK	1.10763383
38	PLK4	1.08249713
39	WNK3	1.08094643
40	TEC	1.07071290
41	INSRR	1.04307492
42	CDK8	1.01412446
43	MAPKAPK3	1.01320765
44	CSNK1G1	0.97900280
45	SRPK1	0.97639071
46	MAP3K11	0.95867902
47	MYLK	0.92308662
48	TNK2	0.92290421
49	PLK2	0.89831490
50	PLK1	0.87672006
51	MAP4K1	0.87499228
52	ITK	0.82447240
53	CDK3	0.81950127
54	AURKA	0.80009373
55	TAF1	0.76964553
56	ATR	0.76577371
57	PRKCQ	0.76532462
58	TESK2	0.75273169
59	CAMK1	0.74184970
60	TNIK	0.72577741
61	OBSCN	0.71570080
62	DAPK1	0.69953129
63	AURKB	0.69926585
64	NTRK2	0.68237867
65	PAK3	0.68147018
66	BRSK1	0.64075514
67	PRKCG	0.61825769
68	CCNB1	0.61443458
69	SGK223	0.60152802
70	SGK494	0.60152802
71	TSSK6	0.59807845
72	MAPK13	0.59720306
73	CSNK1G3	0.59173203
74	SYK	0.59019576
75	ADRBK1	0.56741954
76	RPS6KA4	0.56382586
77	RPS6KA5	0.53783261
78	CSNK1A1	0.51996484
79	CSNK2A1	0.51145466
80	NEK1	0.50083088
81	CHEK2	0.49949983
82	CSNK2A2	0.49838062
83	CSNK1G2	0.47673697
84	IKBKB	0.47434939
85	PHKG1	0.45182126
86	PHKG2	0.45182126
87	MAP2K7	0.45043000
88	PRKACA	0.44114009
89	DAPK3	0.43653212
90	PIK3CG	0.43482999
91	FES	0.43172305
92	GRK5	0.40890276
93	MKNK1	0.40858700
94	TRIM28	0.40697022
95	CAMK2A	0.40274650
96	PRKCA	0.40224220
97	BTK	0.40011100
98	IKBKE	0.39482309
99	SGK2	0.38043390
100	PASK	0.37845847

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.20487756
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65945983
3	Ribosome_Homo sapiens_hsa03010	3.45615498
4	Parkinsons disease_Homo sapiens_hsa05012	2.98747340
5	Homologous recombination_Homo sapiens_hsa03440	2.88326472
6	RNA polymerase_Homo sapiens_hsa03020	2.73780322
7	Mismatch repair_Homo sapiens_hsa03430	2.73403058
8	Protein export_Homo sapiens_hsa03060	2.59622410
9	DNA replication_Homo sapiens_hsa03030	2.42958866
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.36404508
11	One carbon pool by folate_Homo sapiens_hsa00670	2.00956724
12	Huntingtons disease_Homo sapiens_hsa05016	1.98941641
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93391080
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90925193
15	Alzheimers disease_Homo sapiens_hsa05010	1.90464119
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87650370
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.86407607
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.82424437
19	RNA degradation_Homo sapiens_hsa03018	1.67045202
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64917982
21	Phototransduction_Homo sapiens_hsa04744	1.53928106
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53470471
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.49020389
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47849030
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47311788
26	Sulfur relay system_Homo sapiens_hsa04122	1.47229634
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43867148
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.43364239
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43061711
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22726224
31	Purine metabolism_Homo sapiens_hsa00230	1.16806227
32	Base excision repair_Homo sapiens_hsa03410	1.12892389
33	Butanoate metabolism_Homo sapiens_hsa00650	1.10570436
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.10296987
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.10188012
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07987802
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.07726950
38	Basal transcription factors_Homo sapiens_hsa03022	1.07674497
39	Spliceosome_Homo sapiens_hsa03040	1.04911968
40	Allograft rejection_Homo sapiens_hsa05330	1.04037063
41	Asthma_Homo sapiens_hsa05310	1.03799142
42	Graft-versus-host disease_Homo sapiens_hsa05332	1.03511038
43	Antigen processing and presentation_Homo sapiens_hsa04612	1.01476448
44	Propanoate metabolism_Homo sapiens_hsa00640	0.99872729
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96329955
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95652598
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90511477
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89787502
49	RNA transport_Homo sapiens_hsa03013	0.89191209
50	Folate biosynthesis_Homo sapiens_hsa00790	0.86951564
51	Peroxisome_Homo sapiens_hsa04146	0.85819304
52	Caffeine metabolism_Homo sapiens_hsa00232	0.82596737
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81827868
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.81209064
55	Nicotine addiction_Homo sapiens_hsa05033	0.80301981
56	Olfactory transduction_Homo sapiens_hsa04740	0.79343422
57	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78159294
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.77901860
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77343488
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.73844152
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.73824310
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73803626
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.72302031
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66947327
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66117386
66	Metabolic pathways_Homo sapiens_hsa01100	0.65169615
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65144383
68	Retinol metabolism_Homo sapiens_hsa00830	0.63212019
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62923398
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61345866
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58909770
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57597271
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57591172
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55767374
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.54361828
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.49921915
77	Morphine addiction_Homo sapiens_hsa05032	0.49876592
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48896602
79	Sulfur metabolism_Homo sapiens_hsa00920	0.47959447
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47641728
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46761248
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45164370
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.44313982
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43523084
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41758519
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.41004517
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38518759
88	Taste transduction_Homo sapiens_hsa04742	0.33856841
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33020442
90	GABAergic synapse_Homo sapiens_hsa04727	0.32978843
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32744187
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31013810
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29361021
94	Glutathione metabolism_Homo sapiens_hsa00480	0.29163335
95	Insulin secretion_Homo sapiens_hsa04911	0.28698385
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.23021412
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21848715
98	Serotonergic synapse_Homo sapiens_hsa04726	0.21241147
99	Mineral absorption_Homo sapiens_hsa04978	0.18861914
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.16540034

HMGB1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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