HMGB1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.43982029
2DNA deamination (GO:0045006)5.34545094
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.87252608
4ATP synthesis coupled proton transport (GO:0015986)4.81153749
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81153749
6ribosomal small subunit assembly (GO:0000028)4.77161789
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75380867
8behavioral response to nicotine (GO:0035095)4.52481347
9protein complex biogenesis (GO:0070271)4.42081226
10protein neddylation (GO:0045116)4.23034234
11maturation of SSU-rRNA (GO:0030490)4.22546264
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13813543
13mitochondrial respiratory chain complex assembly (GO:0033108)4.13114041
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.08007080
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.00853515
16NADH dehydrogenase complex assembly (GO:0010257)4.00853515
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.00853515
18pattern specification involved in kidney development (GO:0061004)3.90004353
19protein-cofactor linkage (GO:0018065)3.88045851
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87993211
21respiratory electron transport chain (GO:0022904)3.83382562
22electron transport chain (GO:0022900)3.82940632
23regulation of cellular amino acid metabolic process (GO:0006521)3.70748085
24viral transcription (GO:0019083)3.68132356
25regulation of chronic inflammatory response (GO:0002676)3.65233074
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64367014
27cytidine deamination (GO:0009972)3.57562617
28cytidine metabolic process (GO:0046087)3.57562617
29cytidine catabolic process (GO:0006216)3.57562617
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56120835
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56120835
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56120835
33ubiquinone biosynthetic process (GO:0006744)3.53761490
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53172692
35translational termination (GO:0006415)3.52136037
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51796792
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51796792
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50403213
39sequestering of actin monomers (GO:0042989)3.47367522
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43174577
41cotranslational protein targeting to membrane (GO:0006613)3.42629015
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.42122390
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39543456
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.39543456
45protein targeting to ER (GO:0045047)3.36656243
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33399780
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25687566
48ubiquinone metabolic process (GO:0006743)3.25033460
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22785040
50nonmotile primary cilium assembly (GO:0035058)3.20535458
51pyrimidine nucleotide catabolic process (GO:0006244)3.20182112
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18736549
53proteasome assembly (GO:0043248)3.18172939
54positive regulation of prostaglandin secretion (GO:0032308)3.17247668
55somite development (GO:0061053)3.15318760
56protein localization to endoplasmic reticulum (GO:0070972)3.15169403
57translational elongation (GO:0006414)3.10437668
58base-excision repair, AP site formation (GO:0006285)3.07526917
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03442829
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03442829
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02829755
62negative regulation of ligase activity (GO:0051352)3.02829755
63hydrogen ion transmembrane transport (GO:1902600)3.01815621
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00518044
65pyrimidine ribonucleoside catabolic process (GO:0046133)2.99575687
66spliceosomal complex assembly (GO:0000245)2.97711922
67protein deneddylation (GO:0000338)2.96791084
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.96599179
69termination of RNA polymerase III transcription (GO:0006386)2.96599179
70maturation of 5.8S rRNA (GO:0000460)2.95829765
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.95329025
72regulation of mitochondrial translation (GO:0070129)2.94090666
73cullin deneddylation (GO:0010388)2.93064733
74platelet dense granule organization (GO:0060155)2.92597159
75DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.91659084
76translation (GO:0006412)2.89579700
77preassembly of GPI anchor in ER membrane (GO:0016254)2.88400082
78replication fork processing (GO:0031297)2.86354213
79quinone biosynthetic process (GO:1901663)2.85286368
80protein peptidyl-prolyl isomerization (GO:0000413)2.85065861
81cytochrome complex assembly (GO:0017004)2.85031793
82regulation of mitotic spindle checkpoint (GO:1903504)2.84281406
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84281406
84metallo-sulfur cluster assembly (GO:0031163)2.82478513
85iron-sulfur cluster assembly (GO:0016226)2.82478513
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81259781
87proton transport (GO:0015992)2.81232501
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.81110476
89chromatin remodeling at centromere (GO:0031055)2.80309063
90ribosomal small subunit biogenesis (GO:0042274)2.79674629
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79141771
92GTP biosynthetic process (GO:0006183)2.79081341
93peptidyl-histidine modification (GO:0018202)2.78165951
94positive regulation of cell cycle arrest (GO:0071158)2.78023829
95intracellular protein transmembrane import (GO:0044743)2.77523729
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76627282
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75416933
98hydrogen transport (GO:0006818)2.74453478
99cellular component biogenesis (GO:0044085)2.71429258
100rRNA catabolic process (GO:0016075)2.69235537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99458986
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.30531861
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22839594
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.82900025
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.45251742
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02113564
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95574074
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.89143455
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76237966
10ZNF274_21170338_ChIP-Seq_K562_Hela2.66395906
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62622674
12VDR_23849224_ChIP-Seq_CD4+_Human2.29896108
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28222345
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.20063706
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17576611
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15782610
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14649196
18VDR_22108803_ChIP-Seq_LS180_Human2.13289786
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10658798
20ELK1_19687146_ChIP-ChIP_HELA_Human2.09534478
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97370380
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89846549
23IGF1R_20145208_ChIP-Seq_DFB_Human1.87836153
24FOXP3_21729870_ChIP-Seq_TREG_Human1.84882544
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82087695
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.81393939
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75189403
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72783644
29MYC_18940864_ChIP-ChIP_HL60_Human1.71176558
30TP53_22573176_ChIP-Seq_HFKS_Human1.69781115
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.65098310
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62603080
33IRF1_19129219_ChIP-ChIP_H3396_Human1.57590934
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57132923
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53241161
36GABP_19822575_ChIP-Seq_HepG2_Human1.45292748
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.45013731
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41459785
39TTF2_22483619_ChIP-Seq_HELA_Human1.40252095
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.34919258
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32070274
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.30839091
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29104804
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27532675
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27342424
46EWS_26573619_Chip-Seq_HEK293_Human1.25625475
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21798977
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21126751
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18023043
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.17503100
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15976472
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15464963
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15340194
54XRN2_22483619_ChIP-Seq_HELA_Human1.13556382
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.12760097
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12760097
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12203813
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12186438
59AR_20517297_ChIP-Seq_VCAP_Human1.08075920
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07319272
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07234770
62CBP_20019798_ChIP-Seq_JUKART_Human1.07234770
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07024515
64TAF2_19829295_ChIP-Seq_ESCs_Human1.06085859
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.05990098
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.04462111
67NCOR_22424771_ChIP-Seq_293T_Human1.03327804
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02645581
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02611390
70ERA_21632823_ChIP-Seq_H3396_Human1.02415902
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01896357
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01728369
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00574230
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99034921
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98025869
76E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97115878
77ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96349163
78DCP1A_22483619_ChIP-Seq_HELA_Human0.95118137
79NANOG_20526341_ChIP-Seq_ESCs_Human0.93770470
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93682338
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93279711
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93115840
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92977944
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92469949
85CIITA_25753668_ChIP-Seq_RAJI_Human0.92277608
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91952344
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.90118198
88HOXB7_26014856_ChIP-Seq_BT474_Human0.88346906
89MYC_19829295_ChIP-Seq_ESCs_Human0.86887975
90REST_21632747_ChIP-Seq_MESCs_Mouse0.86745964
91RNF2_27304074_Chip-Seq_NSC_Mouse0.85861238
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85252371
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84700282
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84451748
95FUS_26573619_Chip-Seq_HEK293_Human0.84231555
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84094681
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84017000
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83900520
99BCAT_22108803_ChIP-Seq_LS180_Human0.82975381
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80579173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.21480319
2MP0008789_abnormal_olfactory_epithelium2.87235512
3MP0006292_abnormal_olfactory_placode2.60537173
4MP0002102_abnormal_ear_morphology2.60535144
5MP0002653_abnormal_ependyma_morphology2.54932333
6MP0008877_abnormal_DNA_methylation2.40554260
7MP0001348_abnormal_lacrimal_gland2.35773381
8MP0005394_taste/olfaction_phenotype2.27629172
9MP0005499_abnormal_olfactory_system2.27629172
10MP0002163_abnormal_gland_morphology2.24224978
11MP0004147_increased_porphyrin_level2.23380318
12MP0002638_abnormal_pupillary_reflex2.17642107
13MP0005377_hearing/vestibular/ear_phenot2.15773444
14MP0003878_abnormal_ear_physiology2.15773444
15MP0005645_abnormal_hypothalamus_physiol2.14946106
16MP0005671_abnormal_response_to2.13415826
17MP0003646_muscle_fatigue2.06748570
18MP0001968_abnormal_touch/_nociception2.03261730
19MP0000569_abnormal_digit_pigmentation2.02200647
20MP0000685_abnormal_immune_system2.01310520
21MP0001529_abnormal_vocalization1.97056722
22MP0003011_delayed_dark_adaptation1.92879870
23MP0008872_abnormal_physiological_respon1.89685311
24MP0001905_abnormal_dopamine_level1.80660968
25MP0001984_abnormal_olfaction1.79603247
26MP0004145_abnormal_muscle_electrophysio1.79208421
27MP0006072_abnormal_retinal_apoptosis1.77795537
28MP0005551_abnormal_eye_electrophysiolog1.73628190
29MP0002138_abnormal_hepatobiliary_system1.68134859
30MP0008875_abnormal_xenobiotic_pharmacok1.66137192
31MP0003880_abnormal_central_pattern1.65520745
32MP0002876_abnormal_thyroid_physiology1.60740462
33MP0005084_abnormal_gallbladder_morpholo1.60599005
34MP0008058_abnormal_DNA_repair1.57419643
35MP0003787_abnormal_imprinting1.56781953
36MP0002095_abnormal_skin_pigmentation1.56274944
37MP0004142_abnormal_muscle_tone1.53144042
38MP0001293_anophthalmia1.52970055
39MP0002736_abnormal_nociception_after1.50128740
40MP0003121_genomic_imprinting1.48800231
41MP0009745_abnormal_behavioral_response1.42086318
42MP0001501_abnormal_sleep_pattern1.39804838
43MP0001919_abnormal_reproductive_system1.37979591
44MP0005389_reproductive_system_phenotype1.34546440
45MP0006276_abnormal_autonomic_nervous1.29933270
46MP0002272_abnormal_nervous_system1.29208027
47MP0002234_abnormal_pharynx_morphology1.25613840
48MP0005379_endocrine/exocrine_gland_phen1.22897319
49MP0002557_abnormal_social/conspecific_i1.22714198
50MP0005253_abnormal_eye_physiology1.21444132
51MP0003195_calcinosis1.16384657
52MP0001986_abnormal_taste_sensitivity1.15625549
53MP0003122_maternal_imprinting1.14858740
54MP0000778_abnormal_nervous_system1.14708624
55MP0001485_abnormal_pinna_reflex1.08705446
56MP0003136_yellow_coat_color1.08197814
57MP0001502_abnormal_circadian_rhythm1.07792551
58MP0010094_abnormal_chromosome_stability1.07145643
59MP0002733_abnormal_thermal_nociception1.06859349
60MP0003693_abnormal_embryo_hatching1.06618135
61MP0009046_muscle_twitch1.06447010
62MP0003806_abnormal_nucleotide_metabolis1.02777982
63MP0001835_abnormal_antigen_presentation1.02052114
64MP0000049_abnormal_middle_ear1.01932588
65MP0002277_abnormal_respiratory_mucosa0.99091797
66MP0001970_abnormal_pain_threshold0.97560567
67MP0001440_abnormal_grooming_behavior0.97379432
68MP0000631_abnormal_neuroendocrine_gland0.96747322
69MP0005195_abnormal_posterior_eye0.96728358
70MP0002735_abnormal_chemical_nociception0.96670305
71MP0002184_abnormal_innervation0.95034387
72MP0002837_dystrophic_cardiac_calcinosis0.94925355
73MP0001188_hyperpigmentation0.93475405
74MP0004885_abnormal_endolymph0.93375655
75MP0000427_abnormal_hair_cycle0.92123799
76MP0002148_abnormal_hypersensitivity_rea0.90980905
77MP0005646_abnormal_pituitary_gland0.90711806
78MP0008995_early_reproductive_senescence0.89958875
79MP0005174_abnormal_tail_pigmentation0.86335936
80MP0004742_abnormal_vestibular_system0.85701978
81MP0002160_abnormal_reproductive_system0.84863968
82MP0002752_abnormal_somatic_nervous0.84331454
83MP0000372_irregular_coat_pigmentation0.83560870
84MP0001486_abnormal_startle_reflex0.83048114
85MP0002210_abnormal_sex_determination0.82629220
86MP0002572_abnormal_emotion/affect_behav0.81963063
87MP0009333_abnormal_splenocyte_physiolog0.81953159
88MP0005387_immune_system_phenotype0.80974932
89MP0001790_abnormal_immune_system0.80974932
90MP0002282_abnormal_trachea_morphology0.80080810
91MP0002063_abnormal_learning/memory/cond0.76661553
92MP0009764_decreased_sensitivity_to0.76181257
93MP0001542_abnormal_bone_strength0.75963297
94MP0003936_abnormal_reproductive_system0.74688561
95MP0000026_abnormal_inner_ear0.73788562
96MP0003186_abnormal_redox_activity0.72650765
97MP0002067_abnormal_sensory_capabilities0.70130654
98MP0000566_synostosis0.69047282
99MP0003635_abnormal_synaptic_transmissio0.68969605
100MP0004924_abnormal_behavior0.68568223

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.10571926
2Abnormal mitochondria in muscle tissue (HP:0008316)4.55606762
3Acute encephalopathy (HP:0006846)4.32774676
43-Methylglutaconic aciduria (HP:0003535)4.25841083
5Molar tooth sign on MRI (HP:0002419)4.18103782
6Abnormality of midbrain morphology (HP:0002418)4.18103782
7Progressive macrocephaly (HP:0004481)4.14054210
8Mitochondrial inheritance (HP:0001427)4.10444449
9Pancreatic cysts (HP:0001737)3.80095133
10Increased CSF lactate (HP:0002490)3.72804306
11Congenital, generalized hypertrichosis (HP:0004540)3.58248807
12Hepatocellular necrosis (HP:0001404)3.46090380
13Hepatic necrosis (HP:0002605)3.18338319
14Pancreatic fibrosis (HP:0100732)3.15925394
15Supernumerary spleens (HP:0009799)3.08797289
16Cerebral edema (HP:0002181)3.08750006
17Colon cancer (HP:0003003)2.98679654
18Increased hepatocellular lipid droplets (HP:0006565)2.92277360
19Tubular atrophy (HP:0000092)2.87858544
20Oligodactyly (hands) (HP:0001180)2.87072546
21Congenital stationary night blindness (HP:0007642)2.86348733
22True hermaphroditism (HP:0010459)2.84757591
23Nephronophthisis (HP:0000090)2.76238531
24Lipid accumulation in hepatocytes (HP:0006561)2.75034078
25Rib fusion (HP:0000902)2.75017082
26Abnormality of the labia minora (HP:0012880)2.71026677
27Reticulocytopenia (HP:0001896)2.68764417
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66668911
29Abnormality of cells of the erythroid lineage (HP:0012130)2.66135593
30Abnormal rod and cone electroretinograms (HP:0008323)2.65619614
31Optic disc pallor (HP:0000543)2.63767564
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55438051
33Hypoproteinemia (HP:0003075)2.46786280
34Oligodactyly (HP:0012165)2.44955449
35Abnormality of the renal medulla (HP:0100957)2.42730387
36Medial flaring of the eyebrow (HP:0010747)2.41325364
37Increased serum lactate (HP:0002151)2.40102318
38Absent thumb (HP:0009777)2.37241462
39Renal Fanconi syndrome (HP:0001994)2.35605378
40Leukodystrophy (HP:0002415)2.35570071
41Bile duct proliferation (HP:0001408)2.32964842
42Abnormal biliary tract physiology (HP:0012439)2.32964842
43Abnormality of the pons (HP:0007361)2.32863394
44Abnormal number of erythroid precursors (HP:0012131)2.31976970
45Type II lissencephaly (HP:0007260)2.31567975
46Cystic liver disease (HP:0006706)2.27047675
47Macrocytic anemia (HP:0001972)2.26426654
48Abnormal drinking behavior (HP:0030082)2.25428987
49Polydipsia (HP:0001959)2.25428987
50Abnormality of the renal cortex (HP:0011035)2.25396668
51Lactic acidosis (HP:0003128)2.24710212
52Fibular aplasia (HP:0002990)2.21682544
53Increased intramyocellular lipid droplets (HP:0012240)2.09737521
54Aplasia/hypoplasia of the uterus (HP:0008684)2.09071252
55Male pseudohermaphroditism (HP:0000037)2.08987415
56X-linked dominant inheritance (HP:0001423)2.08961926
57Hypoplasia of the pons (HP:0012110)2.06467597
58Sclerocornea (HP:0000647)2.05851794
59Aplastic anemia (HP:0001915)2.04426574
60Gait imbalance (HP:0002141)2.02159418
61Exertional dyspnea (HP:0002875)2.01284624
62IgG deficiency (HP:0004315)2.00636403
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00612609
64Abnormality of the phalanges of the 5th finger (HP:0004213)1.99110932
65Aplasia/Hypoplasia of the spleen (HP:0010451)1.97699306
66Respiratory failure (HP:0002878)1.94462101
67Horseshoe kidney (HP:0000085)1.92418330
68Lethargy (HP:0001254)1.91864506
69Delayed CNS myelination (HP:0002188)1.90338103
70Polyuria (HP:0000103)1.87619222
71Pendular nystagmus (HP:0012043)1.87101150
72Exercise intolerance (HP:0003546)1.85574321
73Congenital primary aphakia (HP:0007707)1.83128601
74Abnormality of alanine metabolism (HP:0010916)1.82501235
75Hyperalaninemia (HP:0003348)1.82501235
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82501235
77Symphalangism affecting the phalanges of the hand (HP:0009773)1.81109556
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.80575520
79Asplenia (HP:0001746)1.77753440
80Anencephaly (HP:0002323)1.74695742
81Aplasia/Hypoplasia of the patella (HP:0006498)1.74357921
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73841482
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73841482
84Lissencephaly (HP:0001339)1.72336772
85Abolished electroretinogram (ERG) (HP:0000550)1.71820666
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71770113
87Constricted visual fields (HP:0001133)1.70620447
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.69994506
89Pallor (HP:0000980)1.69716477
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69474614
91Abnormality of the renal collecting system (HP:0004742)1.69233143
92Duplicated collecting system (HP:0000081)1.67727740
93Patellar aplasia (HP:0006443)1.67397806
94Depressed nasal ridge (HP:0000457)1.65690155
95Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64669813
96Pachygyria (HP:0001302)1.64407105
97Increased muscle lipid content (HP:0009058)1.63324223
98Oral leukoplakia (HP:0002745)1.62334765
99Aganglionic megacolon (HP:0002251)1.61174654
100Cleft eyelid (HP:0000625)1.60497093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.41965319
2MAP4K23.08639845
3WNK43.00765463
4SRPK12.89794676
5VRK22.64372880
6ZAK2.50283453
7TLK12.48141125
8TAOK32.34297847
9ADRBK22.19168962
10STK392.07470958
11STK162.03998174
12NUAK11.96794236
13BCKDK1.91274580
14BCR1.85977160
15WNK31.81815271
16LIMK11.65344047
17NME11.63579118
18CDK81.62754772
19EPHA41.61121688
20GRK11.54778981
21DYRK21.49588679
22CAMKK21.44581370
23VRK11.33069657
24CDC71.29878356
25MAPK131.23298905
26PINK11.22205683
27EPHB21.19970502
28OXSR11.19699508
29TRIM281.14690663
30FRK1.09639560
31NEK11.05447744
32PLK31.04507117
33WEE11.03424289
34MAP2K71.02083990
35PIK3CA0.99526032
36TSSK60.97633210
37MAP3K110.94452000
38CCNB10.93461298
39MAP2K60.92696959
40PIM20.92375182
41DAPK20.92000965
42PLK40.90977979
43MAP3K40.90253504
44EIF2AK20.89973804
45MARK10.88453871
46PAK30.87719459
47EIF2AK30.86518071
48PRKCG0.86310417
49MKNK20.85963512
50ATR0.85928080
51PLK20.84749640
52PHKG20.83641672
53PHKG10.83641672
54MUSK0.83193491
55EIF2AK10.82936657
56PAK60.81212763
57KDR0.79411638
58CSNK1G30.79254064
59BMPR1B0.78530306
60TIE10.77958860
61BUB10.77817349
62TESK20.75824320
63MINK10.74900437
64PLK10.73553122
65TAF10.70500872
66TESK10.69848169
67LRRK20.68377820
68TNIK0.67337805
69CAMKK10.66253021
70CAMK10.65063353
71CHEK20.63950248
72PASK0.63503487
73CSNK1A1L0.62451294
74AURKB0.60920895
75INSRR0.60286318
76MKNK10.59258494
77MAP3K120.56949644
78CSNK1G20.56768866
79MAPKAPK30.56759644
80NTRK20.56412061
81GRK70.55825829
82CSNK1G10.55616071
83CSNK1E0.53129094
84CSNK2A20.53118384
85PNCK0.52791391
86PRKCQ0.51827937
87CSNK2A10.51695080
88PDK20.51611359
89MARK30.51257218
90RPS6KA50.49561892
91AURKA0.49350264
92RPS6KA40.48671232
93CAMK2A0.48454680
94DAPK30.48273083
95MST40.47546530
96SYK0.47492742
97BRSK10.46991127
98CSNK1A10.46921175
99CDK140.46528476
100PRKACA0.40682837

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.87646687
2Oxidative phosphorylation_Homo sapiens_hsa001904.02709710
3Ribosome_Homo sapiens_hsa030103.65098496
4Parkinsons disease_Homo sapiens_hsa050123.30376203
5Protein export_Homo sapiens_hsa030603.11963298
6RNA polymerase_Homo sapiens_hsa030202.99774885
7Mismatch repair_Homo sapiens_hsa034302.47519496
8Huntingtons disease_Homo sapiens_hsa050162.31508278
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20321921
10Alzheimers disease_Homo sapiens_hsa050102.19316928
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13492975
12Homologous recombination_Homo sapiens_hsa034402.07144996
13Cardiac muscle contraction_Homo sapiens_hsa042602.00429430
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96657386
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88727339
16RNA degradation_Homo sapiens_hsa030181.73214306
17Linoleic acid metabolism_Homo sapiens_hsa005911.68955389
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67801077
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66798127
20Phototransduction_Homo sapiens_hsa047441.65090768
21DNA replication_Homo sapiens_hsa030301.60791097
22Fanconi anemia pathway_Homo sapiens_hsa034601.60489222
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55765318
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52274353
25One carbon pool by folate_Homo sapiens_hsa006701.48579915
26Asthma_Homo sapiens_hsa053101.42612021
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41651169
28Pyrimidine metabolism_Homo sapiens_hsa002401.37389841
29Spliceosome_Homo sapiens_hsa030401.37126680
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.30820991
31Tryptophan metabolism_Homo sapiens_hsa003801.28787900
32Nucleotide excision repair_Homo sapiens_hsa034201.27224221
33Propanoate metabolism_Homo sapiens_hsa006401.25324533
34Primary immunodeficiency_Homo sapiens_hsa053401.24924607
35Base excision repair_Homo sapiens_hsa034101.19548113
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14722717
37Butanoate metabolism_Homo sapiens_hsa006501.13821242
38Allograft rejection_Homo sapiens_hsa053301.10216636
39Basal transcription factors_Homo sapiens_hsa030221.09762644
40Nitrogen metabolism_Homo sapiens_hsa009101.07279947
41Autoimmune thyroid disease_Homo sapiens_hsa053201.07231823
42Non-homologous end-joining_Homo sapiens_hsa034500.99751511
43Purine metabolism_Homo sapiens_hsa002300.97652929
44Steroid biosynthesis_Homo sapiens_hsa001000.93660770
45Graft-versus-host disease_Homo sapiens_hsa053320.89500936
46Caffeine metabolism_Homo sapiens_hsa002320.89472401
47Peroxisome_Homo sapiens_hsa041460.86879437
48Ether lipid metabolism_Homo sapiens_hsa005650.84287825
49RNA transport_Homo sapiens_hsa030130.84271494
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84071744
51Antigen processing and presentation_Homo sapiens_hsa046120.80352942
52Collecting duct acid secretion_Homo sapiens_hsa049660.78793165
53Type I diabetes mellitus_Homo sapiens_hsa049400.78103938
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.76164177
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74590566
56Hematopoietic cell lineage_Homo sapiens_hsa046400.72547450
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65699744
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64421224
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63841856
60Nicotine addiction_Homo sapiens_hsa050330.63425590
61Metabolic pathways_Homo sapiens_hsa011000.63041189
62beta-Alanine metabolism_Homo sapiens_hsa004100.58932473
63Arachidonic acid metabolism_Homo sapiens_hsa005900.56585992
64Fat digestion and absorption_Homo sapiens_hsa049750.54901407
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.53925093
66Sulfur relay system_Homo sapiens_hsa041220.53193849
67Chemical carcinogenesis_Homo sapiens_hsa052040.50391348
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49373507
69Rheumatoid arthritis_Homo sapiens_hsa053230.48967372
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48168767
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.46873371
72Folate biosynthesis_Homo sapiens_hsa007900.42488925
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.42060626
74Olfactory transduction_Homo sapiens_hsa047400.41546681
75Phenylalanine metabolism_Homo sapiens_hsa003600.40559430
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.40478503
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39000260
78Regulation of autophagy_Homo sapiens_hsa041400.38612545
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38006425
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.37028193
81Selenocompound metabolism_Homo sapiens_hsa004500.34494678
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33790242
83Morphine addiction_Homo sapiens_hsa050320.32213713
84Epstein-Barr virus infection_Homo sapiens_hsa051690.32156343
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30681986
86Fatty acid degradation_Homo sapiens_hsa000710.30537449
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29724263
88Retinol metabolism_Homo sapiens_hsa008300.29286416
89Tyrosine metabolism_Homo sapiens_hsa003500.27321869
90Sulfur metabolism_Homo sapiens_hsa009200.25885318
91Pyruvate metabolism_Homo sapiens_hsa006200.23508427
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22176117
93Fatty acid elongation_Homo sapiens_hsa000620.21359780
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21287357
95Taste transduction_Homo sapiens_hsa047420.19085011
96Hedgehog signaling pathway_Homo sapiens_hsa043400.19048558
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17925979
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17242277
99GABAergic synapse_Homo sapiens_hsa047270.16205046
100Glycerolipid metabolism_Homo sapiens_hsa005610.15924632

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