HMGB1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)6.90999293
2ribosomal small subunit assembly (GO:0000028)6.28492255
3response to gravity (GO:0009629)5.68329136
4chaperone-mediated protein transport (GO:0072321)5.41659475
5ATP synthesis coupled proton transport (GO:0015986)4.76533371
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.76533371
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.76063927
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75368916
9protein neddylation (GO:0045116)4.67415899
10DNA replication checkpoint (GO:0000076)4.58120010
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.37461157
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.28386126
13negative regulation of ligase activity (GO:0051352)4.28386126
14regulation of cellular amino acid metabolic process (GO:0006521)4.28252846
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.25956083
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.23674295
17negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.23274978
18mannosylation (GO:0097502)4.19677681
19viral transcription (GO:0019083)4.18379809
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.12102432
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.12102432
22protein maturation by protein folding (GO:0022417)4.11897785
23dolichol-linked oligosaccharide biosynthetic process (GO:0006488)4.07024364
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.04941447
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.04929659
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.04929659
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.04929659
28translational termination (GO:0006415)4.00536903
29ribosomal small subunit biogenesis (GO:0042274)3.99518566
30sequestering of actin monomers (GO:0042989)3.97968770
31cotranslational protein targeting to membrane (GO:0006613)3.86841150
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.84898808
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.84898808
34glomerular visceral epithelial cell development (GO:0072015)3.84837490
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82459922
36translational elongation (GO:0006414)3.82177074
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81603695
38galactose catabolic process (GO:0019388)3.81407176
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.78170066
40negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.77757534
41negative regulation of telomere maintenance (GO:0032205)3.76610889
42respiratory electron transport chain (GO:0022904)3.72388386
43protein targeting to ER (GO:0045047)3.72032643
44electron transport chain (GO:0022900)3.71402479
45GDP-mannose metabolic process (GO:0019673)3.68556039
46rRNA catabolic process (GO:0016075)3.67666065
47DNA deamination (GO:0045006)3.67617334
48protein localization to endoplasmic reticulum (GO:0070972)3.58533410
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57476714
50cullin deneddylation (GO:0010388)3.54617674
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52318133
52cellular response to ATP (GO:0071318)3.51790234
53DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.45528200
54protein K63-linked deubiquitination (GO:0070536)3.44902505
55response to interferon-beta (GO:0035456)3.39801490
56maturation of 5.8S rRNA (GO:0000460)3.39416911
57resolution of meiotic recombination intermediates (GO:0000712)3.37948112
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.37839879
59positive regulation of ligase activity (GO:0051351)3.35216879
60glomerular epithelial cell development (GO:0072310)3.34144989
61protein complex biogenesis (GO:0070271)3.33676322
62regulation of mitochondrial translation (GO:0070129)3.32371873
63mitochondrial respiratory chain complex assembly (GO:0033108)3.30475563
64translation (GO:0006412)3.26960801
65protein deneddylation (GO:0000338)3.22766846
66positive regulation of cell cycle arrest (GO:0071158)3.21848138
67negative regulation of DNA-templated transcription, elongation (GO:0032785)3.19219870
68viral mRNA export from host cell nucleus (GO:0046784)3.16890840
69DNA strand elongation involved in DNA replication (GO:0006271)3.15568021
70water-soluble vitamin biosynthetic process (GO:0042364)3.14213480
71viral life cycle (GO:0019058)3.11697482
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09550899
73regulation of cellular amine metabolic process (GO:0033238)3.09252081
74cellular protein complex disassembly (GO:0043624)3.07968505
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06419664
76establishment of viral latency (GO:0019043)3.06145238
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.05007978
78ncRNA catabolic process (GO:0034661)3.02628219
79translational initiation (GO:0006413)2.96527043
80DNA strand elongation (GO:0022616)2.95396724
81skeletal muscle tissue regeneration (GO:0043403)2.94852545
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92572466
83negative regulation of protein ubiquitination (GO:0031397)2.90963972
84cellular response to interferon-beta (GO:0035458)2.90503991
85regulation of cell cycle arrest (GO:0071156)2.89620308
86GTP biosynthetic process (GO:0006183)2.89559862
87pattern specification involved in kidney development (GO:0061004)2.89451307
88regulation of ligase activity (GO:0051340)2.88528527
89signal transduction in response to DNA damage (GO:0042770)2.88003360
90mitochondrial respiratory chain complex I assembly (GO:0032981)2.87477724
91NADH dehydrogenase complex assembly (GO:0010257)2.87477724
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87477724
93detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.83008307
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81143197
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81143197
96peroxisome fission (GO:0016559)2.80744603
97telencephalon development (GO:0021537)2.78989032
98transcription-coupled nucleotide-excision repair (GO:0006283)2.77097147
99proteasome assembly (GO:0043248)2.76447022
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74455598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.19030059
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.15624420
3E2F7_22180533_ChIP-Seq_HELA_Human4.12398148
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.00510824
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.85844295
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.85170978
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.63526520
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61936898
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38604341
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.00945269
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96871655
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96502205
13ELK1_19687146_ChIP-ChIP_HELA_Human2.78625063
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76295939
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71923579
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71124555
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67886797
18VDR_23849224_ChIP-Seq_CD4+_Human2.55792324
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.53009303
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.45865211
21VDR_22108803_ChIP-Seq_LS180_Human2.42710677
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38305674
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34206543
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.29695212
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15618686
26FOXP3_21729870_ChIP-Seq_TREG_Human2.11200129
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10454101
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02913623
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00867171
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90504215
31ELK1_22589737_ChIP-Seq_MCF10A_Human1.88655389
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.84183282
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78703971
34MYC_18940864_ChIP-ChIP_HL60_Human1.72687151
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71238087
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68469393
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68027813
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67762649
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67762649
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67762649
41XRN2_22483619_ChIP-Seq_HELA_Human1.67599956
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67411104
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59644908
44GABP_19822575_ChIP-Seq_HepG2_Human1.58879500
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.58090304
46DCP1A_22483619_ChIP-Seq_HELA_Human1.53052350
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50979894
48TTF2_22483619_ChIP-Seq_HELA_Human1.49445256
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48119606
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39559868
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35256460
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35146042
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35068864
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32859040
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30428732
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26904242
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23940957
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22530883
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21425582
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19260333
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18702950
62EWS_26573619_Chip-Seq_HEK293_Human1.18327403
63TP53_22573176_ChIP-Seq_HFKS_Human1.10842227
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10751486
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09638898
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08724167
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05119751
68HTT_18923047_ChIP-ChIP_STHdh_Human1.03177828
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01765789
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01476571
71HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98726271
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97476147
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96777940
74AR_20517297_ChIP-Seq_VCAP_Human0.95189162
75CBP_21632823_ChIP-Seq_H3396_Human0.93312460
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92019737
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90475454
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89405314
79MYC_19829295_ChIP-Seq_ESCs_Human0.89341944
80OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89269261
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89088243
82EOMES_21245162_ChIP-Seq_HESCs_Human0.88264284
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88163923
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88077762
85NANOG_20526341_ChIP-Seq_ESCs_Human0.87846112
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84495016
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84203770
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83707113
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83401754
90SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83103326
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82610404
92GATA3_26560356_Chip-Seq_TH2_Human0.81710280
93TAF2_19829295_ChIP-Seq_ESCs_Human0.81205767
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80735217
95CIITA_25753668_ChIP-Seq_RAJI_Human0.79462204
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.78462898
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78299415
98FOXP1_21924763_ChIP-Seq_HESCs_Human0.77818436
99EZH2_22144423_ChIP-Seq_EOC_Human0.77707680
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76966406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.53357463
2MP0009379_abnormal_foot_pigmentation3.86422379
3MP0003123_paternal_imprinting3.39889562
4MP0002166_altered_tumor_susceptibility2.95500988
5MP0010030_abnormal_orbit_morphology2.80995202
6MP0000749_muscle_degeneration2.80034036
7MP0002006_tumorigenesis2.61836794
8MP0008875_abnormal_xenobiotic_pharmacok2.58864964
9MP0002277_abnormal_respiratory_mucosa2.54643843
10MP0005408_hypopigmentation2.40846983
11MP0004142_abnormal_muscle_tone2.38576383
12MP0003786_premature_aging2.38420527
13MP0006292_abnormal_olfactory_placode2.15776455
14MP0000569_abnormal_digit_pigmentation2.15348082
15MP0008007_abnormal_cellular_replicative2.05132799
16MP0003045_fibrosis2.03600163
17MP0001905_abnormal_dopamine_level1.93193554
18MP0010094_abnormal_chromosome_stability1.88891958
19MP0006072_abnormal_retinal_apoptosis1.86773161
20MP0008775_abnormal_heart_ventricle1.79896275
21MP0002837_dystrophic_cardiac_calcinosis1.73125285
22MP0005367_renal/urinary_system_phenotyp1.67439188
23MP0000516_abnormal_urinary_system1.67439188
24MP0004957_abnormal_blastocyst_morpholog1.66752937
25MP0000747_muscle_weakness1.66095977
26MP0002938_white_spotting1.64954221
27MP0008877_abnormal_DNA_methylation1.64180124
28MP0001243_abnormal_dermal_layer1.64032076
29MP0003890_abnormal_embryonic-extraembry1.58736711
30MP0002095_abnormal_skin_pigmentation1.48601272
31MP0005083_abnormal_biliary_tract1.46010923
32MP0001293_anophthalmia1.45865614
33MP0004147_increased_porphyrin_level1.40216488
34MP0008058_abnormal_DNA_repair1.39392187
35MP0001485_abnormal_pinna_reflex1.38369395
36MP0003938_abnormal_ear_development1.36116424
37MP0003121_genomic_imprinting1.35796482
38MP0003646_muscle_fatigue1.35058784
39MP0002736_abnormal_nociception_after1.26365727
40MP0000566_synostosis1.21650641
41MP0001542_abnormal_bone_strength1.19306016
42MP0008872_abnormal_physiological_respon1.19000072
43MP0003300_gastrointestinal_ulcer1.18595282
44MP0005671_abnormal_response_to1.18420791
45MP0002282_abnormal_trachea_morphology1.17299691
46MP0003186_abnormal_redox_activity1.16265720
47MP0004145_abnormal_muscle_electrophysio1.15083006
48MP0002638_abnormal_pupillary_reflex1.14684233
49MP0004885_abnormal_endolymph1.12761698
50MP0003567_abnormal_fetal_cardiomyocyte1.10941359
51MP0003195_calcinosis1.10480361
52MP0003315_abnormal_perineum_morphology1.08195348
53MP0000750_abnormal_muscle_regeneration1.05819248
54MP0006276_abnormal_autonomic_nervous1.05751978
55MP0003880_abnormal_central_pattern1.03540271
56MP0005084_abnormal_gallbladder_morpholo1.00324765
57MP0002210_abnormal_sex_determination0.97848810
58MP0004742_abnormal_vestibular_system0.97730702
59MP0006036_abnormal_mitochondrial_physio0.94817443
60MP0003937_abnormal_limbs/digits/tail_de0.93118886
61MP0001340_abnormal_eyelid_morphology0.90785012
62MP0000358_abnormal_cell_content/0.86038040
63MP0005165_increased_susceptibility_to0.84973264
64MP0001764_abnormal_homeostasis0.84438123
65MP0000049_abnormal_middle_ear0.83516671
66MP0005636_abnormal_mineral_homeostasis0.82788760
67MP0003787_abnormal_imprinting0.79870009
68MP0002106_abnormal_muscle_physiology0.79835454
69MP0001919_abnormal_reproductive_system0.78585126
70MP0002109_abnormal_limb_morphology0.78453866
71MP0010368_abnormal_lymphatic_system0.77174352
72MP0000372_irregular_coat_pigmentation0.77136884
73MP0000762_abnormal_tongue_morphology0.74332852
74MP0008932_abnormal_embryonic_tissue0.74072570
75MP0002933_joint_inflammation0.73704725
76MP0002932_abnormal_joint_morphology0.72029153
77MP0005389_reproductive_system_phenotype0.71542393
78MP0006054_spinal_hemorrhage0.71537470
79MP0000631_abnormal_neuroendocrine_gland0.70813868
80MP0005584_abnormal_enzyme/coenzyme_acti0.69769008
81MP0000653_abnormal_sex_gland0.69572804
82MP0003077_abnormal_cell_cycle0.69056883
83MP0005174_abnormal_tail_pigmentation0.67539170
84MP0003718_maternal_effect0.67361449
85MP0001119_abnormal_female_reproductive0.67131134
86MP0009333_abnormal_splenocyte_physiolog0.66903020
87MP0002733_abnormal_thermal_nociception0.66577911
88MP0009046_muscle_twitch0.65160460
89MP0002184_abnormal_innervation0.63917427
90MP0002111_abnormal_tail_morphology0.63581504
91MP0005646_abnormal_pituitary_gland0.63416150
92MP0001963_abnormal_hearing_physiology0.62203958
93MP0002653_abnormal_ependyma_morphology0.62000780
94MP0002896_abnormal_bone_mineralization0.61990996
95MP0003279_aneurysm0.61599425
96MP0001145_abnormal_male_reproductive0.61446310
97MP0002177_abnormal_outer_ear0.61175229
98MP0001765_abnormal_ion_homeostasis0.60859418
99MP0003191_abnormal_cellular_cholesterol0.60211940
100MP0005257_abnormal_intraocular_pressure0.58837554

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.72712611
2Reduced antithrombin III activity (HP:0001976)4.48092710
3Type I transferrin isoform profile (HP:0003642)3.82746154
4Methylmalonic acidemia (HP:0002912)3.80389665
5Mitochondrial inheritance (HP:0001427)3.67239608
6Oligomenorrhea (HP:0000876)3.64585667
7Methylmalonic aciduria (HP:0012120)3.61571877
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.56250181
9Adrenal hypoplasia (HP:0000835)3.47379302
10Abnormal mitochondria in muscle tissue (HP:0008316)3.45849681
11Acute necrotizing encephalopathy (HP:0006965)3.43845710
12Hepatic necrosis (HP:0002605)3.29479900
13Hepatocellular necrosis (HP:0001404)3.27350916
14Delayed CNS myelination (HP:0002188)3.21272471
15Increased CSF lactate (HP:0002490)3.20123100
16Hypoproteinemia (HP:0003075)3.15336130
17Abnormal protein glycosylation (HP:0012346)3.05729671
18Abnormal glycosylation (HP:0012345)3.05729671
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.05729671
20Abnormal protein N-linked glycosylation (HP:0012347)3.05729671
21Stenosis of the external auditory canal (HP:0000402)3.04153694
22Abnormality of DNA repair (HP:0003254)3.03218991
23Hypoplasia of the pons (HP:0012110)2.99239410
24Abnormality of the pons (HP:0007361)2.82601809
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81566221
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81566221
27Progressive macrocephaly (HP:0004481)2.79396740
28Dicarboxylic aciduria (HP:0003215)2.78586540
29Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78586540
30Absent thumb (HP:0009777)2.73269147
31Exercise intolerance (HP:0003546)2.69062750
32Decreased subcutaneous fat (HP:0001002)2.68244046
33Abnormality of the renal cortex (HP:0011035)2.65839079
34Increased intramyocellular lipid droplets (HP:0012240)2.64972946
35Meckel diverticulum (HP:0002245)2.57910345
36Acute encephalopathy (HP:0006846)2.57379897
37Renal cortical cysts (HP:0000803)2.55295229
38Cerebral palsy (HP:0100021)2.54672108
39Colon cancer (HP:0003003)2.51009035
40Abnormality of the ileum (HP:0001549)2.50770774
41Palpitations (HP:0001962)2.49626221
42Increased hepatocellular lipid droplets (HP:0006565)2.49353827
43Palpebral edema (HP:0100540)2.45811973
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.43524935
45Myopathic facies (HP:0002058)2.41636104
46Chromsome breakage (HP:0040012)2.40418119
47Lipid accumulation in hepatocytes (HP:0006561)2.37196504
48Abnormality of cells of the erythroid lineage (HP:0012130)2.36284471
49Congenital, generalized hypertrichosis (HP:0004540)2.30233153
50Flat capital femoral epiphysis (HP:0003370)2.30093250
51Abnormality of the preputium (HP:0100587)2.29744293
52Hypochromic microcytic anemia (HP:0004840)2.29743908
53Pancreatic cysts (HP:0001737)2.26946551
54Septo-optic dysplasia (HP:0100842)2.24820904
55Abnormality of chromosome stability (HP:0003220)2.23080311
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22781001
57Pendular nystagmus (HP:0012043)2.20743597
58Myotonia (HP:0002486)2.19375008
59Increased muscle lipid content (HP:0009058)2.18295851
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.14917043
61CNS demyelination (HP:0007305)2.13639447
62Exertional dyspnea (HP:0002875)2.12424770
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.11577336
64Increased serum lactate (HP:0002151)2.10642528
65Lactic acidosis (HP:0003128)2.09436551
66Respiratory failure (HP:0002878)2.06738468
67Macrocytic anemia (HP:0001972)2.05568100
68Microglossia (HP:0000171)2.05291750
69Opisthotonus (HP:0002179)2.04334415
70Ketosis (HP:0001946)2.03168649
71Asplenia (HP:0001746)2.00201045
72Sclerocornea (HP:0000647)1.96525352
73Esophageal atresia (HP:0002032)1.95288844
74Supernumerary spleens (HP:0009799)1.94179248
75Cerebral edema (HP:0002181)1.93490365
76Abnormality of vitamin B metabolism (HP:0004340)1.93195728
77Delayed gross motor development (HP:0002194)1.92927459
78Renal Fanconi syndrome (HP:0001994)1.91590286
79Reduced subcutaneous adipose tissue (HP:0003758)1.90666261
80Pancreatic fibrosis (HP:0100732)1.90055957
81Abnormal pupillary function (HP:0007686)1.89373435
82Entropion (HP:0000621)1.89181595
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88950223
84Absent phalangeal crease (HP:0006109)1.85591300
85Neuroendocrine neoplasm (HP:0100634)1.83642587
86Clubbing of toes (HP:0100760)1.83629943
87Elevated erythrocyte sedimentation rate (HP:0003565)1.83481248
88Maternal diabetes (HP:0009800)1.83426388
89Aplastic anemia (HP:0001915)1.83426146
90Absent speech (HP:0001344)1.79508849
9111 pairs of ribs (HP:0000878)1.74105342
92Upper limb muscle weakness (HP:0003484)1.73754285
93Myoglobinuria (HP:0002913)1.72166713
94Small intestinal stenosis (HP:0012848)1.72113356
95Duodenal stenosis (HP:0100867)1.72113356
96Supernumerary bones of the axial skeleton (HP:0009144)1.71635552
97Muscle stiffness (HP:0003552)1.69431404
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.69018240
99Pancytopenia (HP:0001876)1.67568171
100Carpal bone hypoplasia (HP:0001498)1.65097563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.05591802
2STK164.11780644
3TESK23.90772839
4LIMK13.67516920
5TESK13.19698149
6TXK2.46121847
7BUB12.37092532
8NME22.34812749
9TAF12.33415649
10NEK92.31798234
11MAP4K22.28773789
12SRPK12.21178341
13MAP3K122.20091666
14VRK12.03877056
15EIF2AK31.98928569
16PHKG11.90980913
17PHKG21.90980913
18TLK11.84935603
19MST41.79763221
20KDR1.72053015
21TAOK31.57656925
22DAPK11.41823588
23CCNB11.40139148
24BCKDK1.40037783
25EIF2AK11.39492426
26MAP3K61.30992273
27PLK41.30226558
28EPHA41.25690992
29TIE11.24761061
30NUAK11.24237867
31AURKA1.23377161
32CLK11.16008158
33WNK31.10877916
34CDC71.04812251
35DYRK21.03589087
36CSNK1G30.95593528
37WNK40.94710961
38MAP2K70.93801086
39GRK10.90930428
40MAP3K110.90852791
41SCYL20.87249782
42ZAP700.87018076
43IKBKE0.86886442
44OBSCN0.84664295
45PIM20.82535438
46AURKB0.80934739
47OXSR10.80555803
48CAMKK20.80182321
49ATR0.79874334
50ARAF0.79866797
51STK390.78617874
52CSNK1G20.78073971
53MAP4K10.74987894
54CSNK1A1L0.73756744
55RPS6KA50.73612690
56DAPK30.71644392
57EIF2AK20.71361541
58TNK20.71264602
59ABL20.69469587
60EPHA20.69402274
61PLK30.67985974
62UHMK10.67092047
63PLK20.66992696
64LRRK20.65827463
65CSNK1G10.63638325
66PLK10.58340503
67MAP2K40.54769614
68CHEK20.52455800
69PRKCE0.51183068
70PDK20.50669458
71LMTK20.48329421
72ADRBK20.45861261
73DAPK20.45751300
74ERBB40.44448063
75PRKCI0.43114558
76GRK50.42780025
77MYLK0.42698997
78NME10.41998389
79CSNK1A10.40560603
80CSNK2A20.38610395
81NEK10.37801512
82INSRR0.37099467
83EPHB20.35830640
84FRK0.35216709
85GRK60.33594848
86PIM10.30997903
87MKNK20.30175889
88PRKCQ0.30131722
89BRSK10.30038025
90MAP2K20.29753613
91BRAF0.29503310
92CSNK2A10.29111836
93MATK0.27574615
94PAK10.27361769
95PTK60.27178071
96MINK10.26936435
97STK100.26245139
98PTK2B0.26224296
99TNIK0.24879254
100PRKACA0.24576309

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.80477773
2Ribosome_Homo sapiens_hsa030104.22257099
3Oxidative phosphorylation_Homo sapiens_hsa001903.82977332
4Parkinsons disease_Homo sapiens_hsa050123.45247434
5DNA replication_Homo sapiens_hsa030303.15618885
6Mismatch repair_Homo sapiens_hsa034302.68008265
7Huntingtons disease_Homo sapiens_hsa050162.46238389
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.43509394
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37120383
10Alzheimers disease_Homo sapiens_hsa050102.35346736
11Homologous recombination_Homo sapiens_hsa034402.34228518
12RNA polymerase_Homo sapiens_hsa030202.06558606
13Nucleotide excision repair_Homo sapiens_hsa034202.01016300
14Fanconi anemia pathway_Homo sapiens_hsa034601.98111353
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94949844
16Cardiac muscle contraction_Homo sapiens_hsa042601.75628309
17Spliceosome_Homo sapiens_hsa030401.72428726
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67786738
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64807959
20Protein export_Homo sapiens_hsa030601.59281243
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54846353
22N-Glycan biosynthesis_Homo sapiens_hsa005101.53533904
23RNA transport_Homo sapiens_hsa030131.52737218
24Caffeine metabolism_Homo sapiens_hsa002321.47875133
25Base excision repair_Homo sapiens_hsa034101.37494737
26Pyrimidine metabolism_Homo sapiens_hsa002401.32537306
27RNA degradation_Homo sapiens_hsa030181.25745060
28Fatty acid elongation_Homo sapiens_hsa000621.24576602
29Folate biosynthesis_Homo sapiens_hsa007901.22334187
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.16355678
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15585298
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12475635
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12174471
34Pyruvate metabolism_Homo sapiens_hsa006201.11535927
35Tryptophan metabolism_Homo sapiens_hsa003801.10108575
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.08267644
37Basal transcription factors_Homo sapiens_hsa030221.07545758
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06995999
39beta-Alanine metabolism_Homo sapiens_hsa004101.01646999
40Fatty acid degradation_Homo sapiens_hsa000710.99649422
41Antigen processing and presentation_Homo sapiens_hsa046120.89788040
42Non-homologous end-joining_Homo sapiens_hsa034500.89141992
43Glutathione metabolism_Homo sapiens_hsa004800.88145999
44Hedgehog signaling pathway_Homo sapiens_hsa043400.85656098
45Histidine metabolism_Homo sapiens_hsa003400.85589360
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83661378
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.74513646
48Galactose metabolism_Homo sapiens_hsa000520.73755160
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73331418
50Propanoate metabolism_Homo sapiens_hsa006400.72039068
51Purine metabolism_Homo sapiens_hsa002300.71164244
52Butanoate metabolism_Homo sapiens_hsa006500.70955101
53Peroxisome_Homo sapiens_hsa041460.70133592
54Chemical carcinogenesis_Homo sapiens_hsa052040.69147079
55Vitamin digestion and absorption_Homo sapiens_hsa049770.66570526
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66420436
57Metabolic pathways_Homo sapiens_hsa011000.64291693
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63637617
59Cell cycle_Homo sapiens_hsa041100.63549750
60Steroid biosynthesis_Homo sapiens_hsa001000.59051429
61Nitrogen metabolism_Homo sapiens_hsa009100.57919940
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54227637
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49146996
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48513736
65Arginine and proline metabolism_Homo sapiens_hsa003300.47818964
66Biosynthesis of amino acids_Homo sapiens_hsa012300.46857403
67Primary immunodeficiency_Homo sapiens_hsa053400.46618811
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46376895
69Salivary secretion_Homo sapiens_hsa049700.45916754
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45744388
71Carbon metabolism_Homo sapiens_hsa012000.40877048
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40298069
73Oocyte meiosis_Homo sapiens_hsa041140.37975617
74Systemic lupus erythematosus_Homo sapiens_hsa053220.37019224
75Epstein-Barr virus infection_Homo sapiens_hsa051690.36549991
76Fructose and mannose metabolism_Homo sapiens_hsa000510.36246537
77Sulfur metabolism_Homo sapiens_hsa009200.34201603
78Sulfur relay system_Homo sapiens_hsa041220.33912383
79Basal cell carcinoma_Homo sapiens_hsa052170.32689344
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.31030158
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29515791
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29440604
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.28643328
84Phototransduction_Homo sapiens_hsa047440.25101356
85One carbon pool by folate_Homo sapiens_hsa006700.23965413
86Retinol metabolism_Homo sapiens_hsa008300.22694879
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22539130
88Regulation of autophagy_Homo sapiens_hsa041400.22399144
89Wnt signaling pathway_Homo sapiens_hsa043100.22069395
90mRNA surveillance pathway_Homo sapiens_hsa030150.21874432
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20930133
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19090121
93Glycerolipid metabolism_Homo sapiens_hsa005610.18918125
94Starch and sucrose metabolism_Homo sapiens_hsa005000.18078890
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.17158506
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16040836
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15633145
98Tight junction_Homo sapiens_hsa045300.15415119
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12780889
100Lysine degradation_Homo sapiens_hsa003100.11457596

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