ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.10674810
2	protein-cofactor linkage (GO:0018065)	5.93493154
3	interleukin-1-mediated signaling pathway (GO:0070498)	5.78926239
4	positive regulation of prostaglandin secretion (GO:0032308)	5.68277628
5	peptidyl-threonine dephosphorylation (GO:0035970)	5.34978977
6	cellular ketone body metabolic process (GO:0046950)	4.71293634
7	behavioral response to nicotine (GO:0035095)	4.68233519
8	positive regulation of heat generation (GO:0031652)	4.63436241
9	regulation of prostaglandin secretion (GO:0032306)	4.61839032
10	positive regulation of T cell cytokine production (GO:0002726)	4.58020271
11	regulation of fever generation (GO:0031620)	4.51219073
12	DNA deamination (GO:0045006)	4.22727014
13	ketone body metabolic process (GO:1902224)	4.19877199
14	ATP synthesis coupled proton transport (GO:0015986)	4.15060035
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.15060035
16	positive regulation of icosanoid secretion (GO:0032305)	3.97408777
17	protein polyglutamylation (GO:0018095)	3.95812478
18	positive regulation of fatty acid transport (GO:2000193)	3.93281606
19	ribosomal small subunit assembly (GO:0000028)	3.88175053
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.76350891
21	termination of RNA polymerase III transcription (GO:0006386)	3.67670123
22	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.67670123
23	ncRNA 3-end processing (GO:0043628)	3.63721409
24	regulation of heat generation (GO:0031650)	3.63351639
25	respiratory chain complex IV assembly (GO:0008535)	3.62437563
26	chromatin remodeling at centromere (GO:0031055)	3.61636844
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.60782442
28	sulfation (GO:0051923)	3.59373027
29	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.58373879
30	amino acid salvage (GO:0043102)	3.54211017
31	L-methionine salvage (GO:0071267)	3.54211017
32	L-methionine biosynthetic process (GO:0071265)	3.54211017
33	kynurenine metabolic process (GO:0070189)	3.53869435
34	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.49095488
35	protein complex biogenesis (GO:0070271)	3.48155481
36	CENP-A containing nucleosome assembly (GO:0034080)	3.47307703
37	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46955714
38	NADH dehydrogenase complex assembly (GO:0010257)	3.46955714
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46955714
40	regulation of microtubule-based movement (GO:0060632)	3.46015476
41	axoneme assembly (GO:0035082)	3.42162978
42	electron transport chain (GO:0022900)	3.39702714
43	respiratory electron transport chain (GO:0022904)	3.38275466
44	indole-containing compound catabolic process (GO:0042436)	3.37351323
45	indolalkylamine catabolic process (GO:0046218)	3.37351323
46	tryptophan catabolic process (GO:0006569)	3.37351323
47	replication fork processing (GO:0031297)	3.33413780
48	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.30524397
49	positive regulation of protein homodimerization activity (GO:0090073)	3.16521760
50	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10357959
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.10003157
52	platelet dense granule organization (GO:0060155)	3.07497613
53	indolalkylamine metabolic process (GO:0006586)	3.05064743
54	negative regulation of telomere maintenance (GO:0032205)	3.04656800
55	rRNA catabolic process (GO:0016075)	3.03459095
56	telomere maintenance via telomerase (GO:0007004)	3.02366878
57	hydrogen ion transmembrane transport (GO:1902600)	3.01163131
58	mitotic cell cycle arrest (GO:0071850)	3.01079279
59	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.98625577
60	regulation of T cell cytokine production (GO:0002724)	2.95026560
61	regulation of icosanoid secretion (GO:0032303)	2.93500784
62	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.93267936
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.89492857
64	AMP metabolic process (GO:0046033)	2.87225274
65	S-adenosylmethionine metabolic process (GO:0046500)	2.86990340
66	bone resorption (GO:0045453)	2.86234426
67	regulation of immunoglobulin secretion (GO:0051023)	2.85158522
68	regulation of cilium movement (GO:0003352)	2.84687837
69	aspartate family amino acid biosynthetic process (GO:0009067)	2.84319213
70	methionine biosynthetic process (GO:0009086)	2.82879173
71	proton transport (GO:0015992)	2.80952449
72	positive regulation of osteoclast differentiation (GO:0045672)	2.77042747
73	retinal cone cell development (GO:0046549)	2.76592569
74	hydrogen transport (GO:0006818)	2.76038079
75	DNA strand renaturation (GO:0000733)	2.75462822
76	GTP biosynthetic process (GO:0006183)	2.74275317
77	L-fucose catabolic process (GO:0042355)	2.74264415
78	fucose catabolic process (GO:0019317)	2.74264415
79	L-fucose metabolic process (GO:0042354)	2.74264415
80	histone exchange (GO:0043486)	2.73700520
81	cytochrome complex assembly (GO:0017004)	2.72012140
82	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.70140562
83	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.68803121
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66506366
85	tryptophan metabolic process (GO:0006568)	2.61554102
86	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.60764703
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.60764703
88	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.60324320
89	piRNA metabolic process (GO:0034587)	2.57049013
90	regulation of action potential (GO:0098900)	2.56070944
91	T-helper 1 type immune response (GO:0042088)	2.51693927
92	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.49849857
93	metallo-sulfur cluster assembly (GO:0031163)	2.46122727
94	iron-sulfur cluster assembly (GO:0016226)	2.46122727
95	response to UV-C (GO:0010225)	2.45760979
96	DNA double-strand break processing (GO:0000729)	2.45622287
97	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.42825468
98	regulation of mitotic spindle checkpoint (GO:1903504)	2.42825468
99	positive regulation of organic acid transport (GO:0032892)	2.42601833
100	ATP biosynthetic process (GO:0006754)	2.42136554

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.09824559
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.64403610
3	VDR_22108803_ChIP-Seq_LS180_Human	3.55240934
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.43350915
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.21440308
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.14152956
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09320118
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.71346811
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48183034
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35942548
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.06387762
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02816965
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.00645590
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.00403747
15	EWS_26573619_Chip-Seq_HEK293_Human	1.92149840
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.91570182
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.89616844
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86415985
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.84197480
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.82637593
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80307023
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.77965285
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.76793518
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.75582686
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71674005
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59231866
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.56583299
28	FUS_26573619_Chip-Seq_HEK293_Human	1.55306495
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.54565268
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.51377396
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51370250
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48888611
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45113310
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43996318
35	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.42667744
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41451337
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41263428
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.40594929
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.38844535
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38484921
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37864587
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34806752
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32629426
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.32629426
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32019939
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30268019
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28839385
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25952972
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25289576
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23626095
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23626095
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22177930
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21883072
54	P300_19829295_ChIP-Seq_ESCs_Human	1.18859822
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17449714
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16938397
57	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14713944
58	NCOR_22424771_ChIP-Seq_293T_Human	1.12705380
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09107358
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09080903
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08641619
62	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07925704
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07538664
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.07407215
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07278783
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06590431
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05773536
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02966598
69	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.02847613
70	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01745982
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01603424
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00642363
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99935422
74	GATA3_26560356_Chip-Seq_TH2_Human	0.99009206
75	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98879048
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98364213
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.97754967
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97542526
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97104473
80	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97064414
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96332342
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95950115
83	TAF15_26573619_Chip-Seq_HEK293_Human	0.95069719
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94530990
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94530990
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.94323086
87	ERA_21632823_ChIP-Seq_H3396_Human	0.94236162
88	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.94205812
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93566786
90	AR_20517297_ChIP-Seq_VCAP_Human	0.93233289
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.92937013
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92933701
93	STAT3_23295773_ChIP-Seq_U87_Human	0.92493617
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92056653
95	CIITA_25753668_ChIP-Seq_RAJI_Human	0.92025523
96	P300_27268052_Chip-Seq_Bcells_Human	0.91344122
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.91302655
98	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.91002390
99	TCF4_23295773_ChIP-Seq_U87_Human	0.90844928
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90544331

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.40530129
2	MP0005084_abnormal_gallbladder_morpholo	2.77816902
3	MP0004885_abnormal_endolymph	2.63067696
4	MP0003195_calcinosis	2.47746898
5	MP0001968_abnormal_touch/_nociception	2.44766125
6	MP0006292_abnormal_olfactory_placode	2.44752582
7	MP0000685_abnormal_immune_system	2.38017443
8	MP0002138_abnormal_hepatobiliary_system	2.37770421
9	MP0008877_abnormal_DNA_methylation	2.34461979
10	MP0008789_abnormal_olfactory_epithelium	2.31609974
11	MP0002095_abnormal_skin_pigmentation	2.24306666
12	MP0004142_abnormal_muscle_tone	2.10273351
13	MP0002876_abnormal_thyroid_physiology	2.09546496
14	MP0004145_abnormal_muscle_electrophysio	2.06750250
15	MP0000569_abnormal_digit_pigmentation	2.05647618
16	MP0003724_increased_susceptibility_to	1.97713980
17	MP0002733_abnormal_thermal_nociception	1.95798960
18	MP0009046_muscle_twitch	1.95260692
19	MP0005551_abnormal_eye_electrophysiolog	1.84980334
20	MP0005646_abnormal_pituitary_gland	1.81447538
21	MP0005499_abnormal_olfactory_system	1.71721039
22	MP0005394_taste/olfaction_phenotype	1.71721039
23	MP0005645_abnormal_hypothalamus_physiol	1.68078185
24	MP0003786_premature_aging	1.66097885
25	MP0001764_abnormal_homeostasis	1.65219654
26	MP0002735_abnormal_chemical_nociception	1.65171240
27	MP0001970_abnormal_pain_threshold	1.58267089
28	MP0009745_abnormal_behavioral_response	1.58171456
29	MP0001905_abnormal_dopamine_level	1.55888516
30	MP0008007_abnormal_cellular_replicative	1.52690669
31	MP0008775_abnormal_heart_ventricle	1.52377201
32	MP0002148_abnormal_hypersensitivity_rea	1.52101494
33	MP0000427_abnormal_hair_cycle	1.51024022
34	MP0002557_abnormal_social/conspecific_i	1.48505647
35	MP0002272_abnormal_nervous_system	1.43850148
36	MP0000631_abnormal_neuroendocrine_gland	1.42332704
37	MP0001501_abnormal_sleep_pattern	1.42076945
38	MP0002006_tumorigenesis	1.42036785
39	MP0002736_abnormal_nociception_after	1.40920608
40	MP0002139_abnormal_hepatobiliary_system	1.36126311
41	MP0008875_abnormal_xenobiotic_pharmacok	1.35928037
42	MP0006276_abnormal_autonomic_nervous	1.34292152
43	MP0003693_abnormal_embryo_hatching	1.33393869
44	MP0001919_abnormal_reproductive_system	1.29928161
45	MP0001486_abnormal_startle_reflex	1.25508898
46	MP0001485_abnormal_pinna_reflex	1.24616524
47	MP0010094_abnormal_chromosome_stability	1.20912339
48	MP0002234_abnormal_pharynx_morphology	1.20843846
49	MP0002064_seizures	1.18841009
50	MP0001881_abnormal_mammary_gland	1.18549722
51	MP0004782_abnormal_surfactant_physiolog	1.18085880
52	MP0005448_abnormal_energy_balance	1.17795269
53	MP0008872_abnormal_physiological_respon	1.17353162
54	MP0005535_abnormal_body_temperature	1.17265159
55	MP0002572_abnormal_emotion/affect_behav	1.14519533
56	MP0002160_abnormal_reproductive_system	1.14236115
57	MP0005389_reproductive_system_phenotype	1.12762515
58	MP0002938_white_spotting	1.11555615
59	MP0000230_abnormal_systemic_arterial	1.11386145
60	MP0001835_abnormal_antigen_presentation	1.11079098
61	MP0002653_abnormal_ependyma_morphology	1.10858988
62	MP0000647_abnormal_sebaceous_gland	1.10281115
63	MP0005671_abnormal_response_to	1.09851426
64	MP0003718_maternal_effect	1.07625400
65	MP0001984_abnormal_olfaction	1.05164621
66	MP0005085_abnormal_gallbladder_physiolo	1.04073935
67	MP0008569_lethality_at_weaning	1.02278944
68	MP0005187_abnormal_penis_morphology	1.01554540
69	MP0002063_abnormal_learning/memory/cond	1.01162230
70	MP0003806_abnormal_nucleotide_metabolis	0.99619287
71	MP0002277_abnormal_respiratory_mucosa	0.99303696
72	MP0002909_abnormal_adrenal_gland	0.98872728
73	MP0001800_abnormal_humoral_immune	0.95736080
74	MP0003646_muscle_fatigue	0.94013434
75	MP0005410_abnormal_fertilization	0.93774174
76	MP0001440_abnormal_grooming_behavior	0.91608140
77	MP0002166_altered_tumor_susceptibility	0.91065527
78	MP0005253_abnormal_eye_physiology	0.89197041
79	MP0005075_abnormal_melanosome_morpholog	0.87325932
80	MP0004742_abnormal_vestibular_system	0.87057913
81	MP0009840_abnormal_foam_cell	0.85531471
82	MP0006072_abnormal_retinal_apoptosis	0.85334336
83	MP0005636_abnormal_mineral_homeostasis	0.84848482
84	MP0001293_anophthalmia	0.84519886
85	MP0002067_abnormal_sensory_capabilities	0.83628057
86	MP0005332_abnormal_amino_acid	0.83460219
87	MP0009764_decreased_sensitivity_to	0.81015886
88	MP0003252_abnormal_bile_duct	0.79777530
89	MP0003635_abnormal_synaptic_transmissio	0.79515147
90	MP0009250_abnormal_appendicular_skeleto	0.77842477
91	MP0003880_abnormal_central_pattern	0.75763834
92	MP0000015_abnormal_ear_pigmentation	0.75358535
93	MP0008995_early_reproductive_senescence	0.75283719
94	MP0002210_abnormal_sex_determination	0.74531970
95	MP0001188_hyperpigmentation	0.73295387
96	MP0003186_abnormal_redox_activity	0.73282759
97	MP0001929_abnormal_gametogenesis	0.72367980
98	MP0003787_abnormal_imprinting	0.71310872
99	MP0002928_abnormal_bile_duct	0.70575316
100	MP0003436_decreased_susceptibility_to	0.69763056

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	4.61708460
2	Abnormality of the labia minora (HP:0012880)	4.43928691
3	Acute necrotizing encephalopathy (HP:0006965)	4.09569000
4	Molar tooth sign on MRI (HP:0002419)	3.93526226
5	Abnormality of midbrain morphology (HP:0002418)	3.93526226
6	Acute encephalopathy (HP:0006846)	3.85199361
7	Pancreatic cysts (HP:0001737)	3.82714181
8	Nephronophthisis (HP:0000090)	3.55877120
9	Mitochondrial inheritance (HP:0001427)	3.40565222
10	True hermaphroditism (HP:0010459)	3.37251827
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.34312790
12	Progressive macrocephaly (HP:0004481)	3.31020948
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.30543649
14	Abnormality of alanine metabolism (HP:0010916)	3.30543649
15	Hyperalaninemia (HP:0003348)	3.30543649
16	Premature loss of primary teeth (HP:0006323)	3.22089267
17	Methylmalonic acidemia (HP:0002912)	3.18998008
18	Increased CSF lactate (HP:0002490)	3.13526320
19	Hyperglycinuria (HP:0003108)	3.08001881
20	Abnormality of glycine metabolism (HP:0010895)	3.06465507
21	Abnormality of serine family amino acid metabolism (HP:0010894)	3.06465507
22	Pancreatic fibrosis (HP:0100732)	3.01810619
23	Attenuation of retinal blood vessels (HP:0007843)	3.01447616
24	Increased density of long bones (HP:0006392)	2.95674863
25	Abnormality of the renal medulla (HP:0100957)	2.95146279
26	Cerebral edema (HP:0002181)	2.84497857
27	Increased hepatocellular lipid droplets (HP:0006565)	2.79252721
28	Chronic hepatic failure (HP:0100626)	2.77820100
29	Optic disc pallor (HP:0000543)	2.76892322
30	Methylmalonic aciduria (HP:0012120)	2.67788166
31	Renal Fanconi syndrome (HP:0001994)	2.63199333
32	Lipid accumulation in hepatocytes (HP:0006561)	2.60892650
33	Hepatocellular necrosis (HP:0001404)	2.59124706
34	Hepatic necrosis (HP:0002605)	2.59007363
35	Congenital stationary night blindness (HP:0007642)	2.50471820
36	Sclerocornea (HP:0000647)	2.47078758
37	Abnormality of the renal cortex (HP:0011035)	2.46766179
38	Disproportionate short-trunk short stature (HP:0003521)	2.41373313
39	3-Methylglutaconic aciduria (HP:0003535)	2.37809053
40	Abnormality of serum amino acid levels (HP:0003112)	2.36214731
41	Medial flaring of the eyebrow (HP:0010747)	2.35506938
42	Persistence of primary teeth (HP:0006335)	2.35034717
43	Increased serum lactate (HP:0002151)	2.31889664
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.30670928
45	Rhinitis (HP:0012384)	2.27533409
46	Abnormality of DNA repair (HP:0003254)	2.23573087
47	Constricted visual fields (HP:0001133)	2.22068271
48	Cystic liver disease (HP:0006706)	2.21370439
49	Gaze-evoked nystagmus (HP:0000640)	2.20346438
50	Decreased central vision (HP:0007663)	2.19236856
51	Type II lissencephaly (HP:0007260)	2.15072480
52	Tubulointerstitial nephritis (HP:0001970)	2.14434543
53	Lethargy (HP:0001254)	2.11959915
54	Agitation (HP:0000713)	2.11280944
55	Ovoid vertebral bodies (HP:0003300)	2.05371963
56	Progressive inability to walk (HP:0002505)	2.05077627
57	Lactic acidosis (HP:0003128)	2.03355709
58	Supernumerary spleens (HP:0009799)	2.02751605
59	Colon cancer (HP:0003003)	2.01544166
60	Male pseudohermaphroditism (HP:0000037)	2.00096947
61	Facial diplegia (HP:0001349)	1.99857811
62	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95807344
63	Exertional dyspnea (HP:0002875)	1.94955294
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94437658
65	Abnormal sex determination (HP:0012244)	1.93431819
66	Sex reversal (HP:0012245)	1.93431819
67	Pancytopenia (HP:0001876)	1.91178757
68	Neuroendocrine neoplasm (HP:0100634)	1.89305858
69	Oligodactyly (hands) (HP:0001180)	1.86767118
70	Type 2 muscle fiber atrophy (HP:0003554)	1.86743872
71	Focal motor seizures (HP:0011153)	1.86525520
72	Abnormality of vitamin B metabolism (HP:0004340)	1.86263344
73	Congenital, generalized hypertrichosis (HP:0004540)	1.80682395
74	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79682795
75	Aplasia/Hypoplasia of the patella (HP:0006498)	1.79019865
76	Azoospermia (HP:0000027)	1.78865464
77	Retinal dysplasia (HP:0007973)	1.78582162
78	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.78206778
79	Patellar aplasia (HP:0006443)	1.78058406
80	IgG deficiency (HP:0004315)	1.76267369
81	Abnormality of urine glucose concentration (HP:0011016)	1.75808594
82	Glycosuria (HP:0003076)	1.75808594
83	Anencephaly (HP:0002323)	1.75159318
84	Postaxial foot polydactyly (HP:0001830)	1.75131571
85	Malignant hyperthermia (HP:0002047)	1.71959780
86	Hypoproteinemia (HP:0003075)	1.71681234
87	Inability to walk (HP:0002540)	1.71672973
88	Gait imbalance (HP:0002141)	1.70802280
89	Lissencephaly (HP:0001339)	1.70016866
90	Hypoplasia of the uterus (HP:0000013)	1.69768736
91	Pendular nystagmus (HP:0012043)	1.67879114
92	Asymmetric septal hypertrophy (HP:0001670)	1.67198676
93	Narrow forehead (HP:0000341)	1.66750059
94	Clubbing of toes (HP:0100760)	1.66454761
95	Gonadal dysgenesis (HP:0000133)	1.65961745
96	Absent thumb (HP:0009777)	1.65485393
97	Blindness (HP:0000618)	1.65435145
98	Birth length less than 3rd percentile (HP:0003561)	1.65098214
99	Abnormality of renal resorption (HP:0011038)	1.62960664
100	Dicarboxylic aciduria (HP:0003215)	1.62810508

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.86907006
2	INSRR	3.32057416
3	BCKDK	3.29266350
4	VRK2	2.86003968
5	ZAK	2.80281638
6	PNCK	2.56942651
7	NUAK1	2.35181572
8	VRK1	2.32425323
9	BUB1	2.22560607
10	TAF1	2.17290506
11	MKNK1	1.82103328
12	PHKG2	1.78619701
13	PHKG1	1.78619701
14	ADRBK2	1.71724331
15	WEE1	1.68927318
16	GRK1	1.67803279
17	EIF2AK2	1.62788044
18	WNK4	1.57428010
19	OXSR1	1.54925755
20	MARK1	1.54326471
21	MAPKAPK5	1.50684003
22	EIF2AK3	1.49959839
23	PLK2	1.48565186
24	FRK	1.47177194
25	NEK9	1.42505267
26	MKNK2	1.38371423
27	PDK2	1.36007362
28	CAMKK2	1.32566071
29	MST4	1.31198782
30	CDK8	1.31090355
31	STK4	1.25653857
32	TSSK6	1.22247105
33	PLK3	1.18633641
34	MAP4K2	1.17414092
35	TIE1	1.12941627
36	CDK19	1.12630062
37	TNK2	1.12198398
38	TAOK3	1.10395386
39	CDC42BPA	1.10276394
40	PRKCI	1.08297283
41	STK39	1.07865651
42	MAP2K2	1.03705148
43	RPS6KA5	0.98848729
44	PLK4	0.98785309
45	PINK1	0.98313249
46	CDC7	0.94826152
47	NEK1	0.92830172
48	CAMKK1	0.89456622
49	PRKCG	0.88750339
50	DAPK1	0.85872056
51	BMPR1B	0.85827933
52	MAPK15	0.83778346
53	GRK7	0.81937754
54	DYRK1A	0.77603234
55	KIT	0.76701025
56	PRKCQ	0.76252524
57	CAMK1G	0.75785404
58	ERBB3	0.75715777
59	ATR	0.74770375
60	DYRK2	0.73395160
61	MAPK13	0.71190200
62	ADRBK1	0.70936143
63	BRSK1	0.70568460
64	FES	0.68919105
65	TXK	0.67586933
66	GRK5	0.66069838
67	DAPK3	0.64557348
68	BRSK2	0.64511239
69	PIM2	0.60795223
70	MINK1	0.58530175
71	CSNK1G3	0.57823867
72	PRKCE	0.57280962
73	IKBKB	0.56246798
74	ALK	0.55565457
75	CSNK1G2	0.55394078
76	SYK	0.52584321
77	MAPKAPK3	0.50956993
78	CHEK2	0.50931586
79	WNK3	0.50795673
80	PAK3	0.49037745
81	PKN1	0.48126404
82	STK16	0.44339407
83	PRKCH	0.43592189
84	KDR	0.42545149
85	CDK14	0.41568315
86	CSNK2A2	0.40610419
87	TNIK	0.40295615
88	PTK2B	0.39987234
89	CSNK1G1	0.39895376
90	CAMK2A	0.39822076
91	CSNK2A1	0.39485593
92	TESK2	0.38110471
93	PRKCA	0.37637495
94	PRKACB	0.36733915
95	CSNK1E	0.36265538
96	CAMK1D	0.35876421
97	PIM1	0.35699273
98	PRKCZ	0.35495227
99	PRKACA	0.34955025
100	MAP3K13	0.34914796

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	5.80449626
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.82935930
3	Parkinsons disease_Homo sapiens_hsa05012	2.66264486
4	One carbon pool by folate_Homo sapiens_hsa00670	2.65569982
5	Asthma_Homo sapiens_hsa05310	2.64500712
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.50073042
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.49728255
8	RNA polymerase_Homo sapiens_hsa03020	2.34554511
9	Proteasome_Homo sapiens_hsa03050	2.34243830
10	Phototransduction_Homo sapiens_hsa04744	2.21614004
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.95381064
12	Propanoate metabolism_Homo sapiens_hsa00640	1.93829219
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87515568
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.79178280
15	Homologous recombination_Homo sapiens_hsa03440	1.76324335
16	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.72436943
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.72042917
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71641121
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.68432791
20	Protein export_Homo sapiens_hsa03060	1.64230466
21	Huntingtons disease_Homo sapiens_hsa05016	1.58940788
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58436074
23	Alzheimers disease_Homo sapiens_hsa05010	1.49544235
24	Butanoate metabolism_Homo sapiens_hsa00650	1.49408768
25	Caffeine metabolism_Homo sapiens_hsa00232	1.45490171
26	Basal transcription factors_Homo sapiens_hsa03022	1.43026233
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41797231
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.37919048
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.37540113
30	Allograft rejection_Homo sapiens_hsa05330	1.35470411
31	Ribosome_Homo sapiens_hsa03010	1.34751688
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.33999100
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32442946
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.29106011
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25416863
36	Mismatch repair_Homo sapiens_hsa03430	1.25277353
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.22009242
38	Peroxisome_Homo sapiens_hsa04146	1.21643806
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16535928
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14863627
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12342306
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10837158
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.08767377
44	Purine metabolism_Homo sapiens_hsa00230	1.07730779
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.05345994
46	Antigen processing and presentation_Homo sapiens_hsa04612	1.01325740
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.98868190
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97308436
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93627232
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91225887
51	DNA replication_Homo sapiens_hsa03030	0.90300426
52	RNA degradation_Homo sapiens_hsa03018	0.88451849
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85057806
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79820982
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76239871
56	Rheumatoid arthritis_Homo sapiens_hsa05323	0.75459756
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74493780
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71660506
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70316039
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69875565
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68730686
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67772487
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67265341
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65990765
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65763629
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65397839
67	RNA transport_Homo sapiens_hsa03013	0.65304641
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64812663
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60918454
70	Metabolic pathways_Homo sapiens_hsa01100	0.58091827
71	Sulfur metabolism_Homo sapiens_hsa00920	0.57693462
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57071771
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.56128538
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55222656
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.55144078
76	Taste transduction_Homo sapiens_hsa04742	0.55020738
77	Serotonergic synapse_Homo sapiens_hsa04726	0.53149279
78	Base excision repair_Homo sapiens_hsa03410	0.52469722
79	Nicotine addiction_Homo sapiens_hsa05033	0.51160254
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47760974
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45256382
82	Olfactory transduction_Homo sapiens_hsa04740	0.44926021
83	Morphine addiction_Homo sapiens_hsa05032	0.44743320
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.44226702
85	Retinol metabolism_Homo sapiens_hsa00830	0.44169822
86	Folate biosynthesis_Homo sapiens_hsa00790	0.43045873
87	Salivary secretion_Homo sapiens_hsa04970	0.39339657
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37573823
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37164241
90	Regulation of autophagy_Homo sapiens_hsa04140	0.37028680
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34866438
92	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33424072
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.32135291
94	ABC transporters_Homo sapiens_hsa02010	0.26731631
95	Mineral absorption_Homo sapiens_hsa04978	0.26582072
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26109289
97	Circadian entrainment_Homo sapiens_hsa04713	0.25428035
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.25383479
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23509836
100	Insulin secretion_Homo sapiens_hsa04911	0.22898140

HMGB1P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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