ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.65558614
2	maturation of SSU-rRNA (GO:0030490)	4.56002535
3	protein complex biogenesis (GO:0070271)	4.48641435
4	kynurenine metabolic process (GO:0070189)	4.45181795
5	heme transport (GO:0015886)	4.21653720
6	adaptation of signaling pathway (GO:0023058)	4.11343237
7	resolution of meiotic recombination intermediates (GO:0000712)	4.10533337
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.10368811
9	NADH dehydrogenase complex assembly (GO:0010257)	4.10368811
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.10368811
11	cellular response to ATP (GO:0071318)	4.10099888
12	mitochondrial respiratory chain complex assembly (GO:0033108)	4.04430291
13	protein-cofactor linkage (GO:0018065)	3.87813512
14	tryptophan catabolic process (GO:0006569)	3.87031097
15	indole-containing compound catabolic process (GO:0042436)	3.87031097
16	indolalkylamine catabolic process (GO:0046218)	3.87031097
17	iron coordination entity transport (GO:1901678)	3.86954818
18	protein neddylation (GO:0045116)	3.86541269
19	ribosomal small subunit assembly (GO:0000028)	3.85637271
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.79506003
21	ATP synthesis coupled proton transport (GO:0015986)	3.79102077
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.79102077
23	tryptophan metabolic process (GO:0006568)	3.77760173
24	respiratory chain complex IV assembly (GO:0008535)	3.70371575
25	replication fork processing (GO:0031297)	3.69674530
26	chaperone-mediated protein transport (GO:0072321)	3.65955853
27	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.63789487
28	regulation of mitotic spindle checkpoint (GO:1903504)	3.63789487
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.56206046
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.56206046
31	indolalkylamine metabolic process (GO:0006586)	3.55691481
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52584859
33	protein K63-linked deubiquitination (GO:0070536)	3.50058671
34	multicellular organism reproduction (GO:0032504)	3.41212702
35	behavioral response to nicotine (GO:0035095)	3.39327498
36	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.35844398
37	L-fucose catabolic process (GO:0042355)	3.34324632
38	fucose catabolic process (GO:0019317)	3.34324632
39	L-fucose metabolic process (GO:0042354)	3.34324632
40	rRNA catabolic process (GO:0016075)	3.33458272
41	maturation of 5.8S rRNA (GO:0000460)	3.33239564
42	cellular ketone body metabolic process (GO:0046950)	3.32777116
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.31512257
44	cytochrome complex assembly (GO:0017004)	3.29535832
45	DNA strand renaturation (GO:0000733)	3.27000639
46	rRNA modification (GO:0000154)	3.22213453
47	rRNA methylation (GO:0031167)	3.20508196
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15088028
49	electron transport chain (GO:0022900)	3.12114233
50	regulation of cellular amino acid metabolic process (GO:0006521)	3.11298689
51	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09184170
52	respiratory electron transport chain (GO:0022904)	3.06323230
53	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.04921525
54	detection of light stimulus involved in visual perception (GO:0050908)	3.03013282
55	detection of light stimulus involved in sensory perception (GO:0050962)	3.03013282
56	ncRNA catabolic process (GO:0034661)	3.01657635
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99342309
58	GDP-mannose metabolic process (GO:0019673)	2.98091683
59	C-terminal protein amino acid modification (GO:0018410)	2.94075650
60	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93995143
61	ketone body metabolic process (GO:1902224)	2.93411124
62	water-soluble vitamin biosynthetic process (GO:0042364)	2.91905394
63	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90797143
64	mismatch repair (GO:0006298)	2.87117118
65	protein peptidyl-prolyl isomerization (GO:0000413)	2.86833001
66	C-terminal protein lipidation (GO:0006501)	2.84621969
67	DNA double-strand break processing (GO:0000729)	2.82961857
68	mannosylation (GO:0097502)	2.82259175
69	GTP biosynthetic process (GO:0006183)	2.82081179
70	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.79334390
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.79127402
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.79127402
73	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.79034055
74	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.79034055
75	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.79034055
76	lactate metabolic process (GO:0006089)	2.78813783
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.78315891
78	DNA catabolic process, exonucleolytic (GO:0000738)	2.76284859
79	positive regulation of prostaglandin secretion (GO:0032308)	2.75391959
80	response to pheromone (GO:0019236)	2.73394318
81	negative regulation of ligase activity (GO:0051352)	2.72959383
82	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.72959383
83	retinal cone cell development (GO:0046549)	2.72865919
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.71895363
85	aromatic amino acid family catabolic process (GO:0009074)	2.70730382
86	mitochondrial RNA metabolic process (GO:0000959)	2.70057387
87	amine catabolic process (GO:0009310)	2.68674655
88	cellular biogenic amine catabolic process (GO:0042402)	2.68674655
89	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.66830751
90	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.66830751
91	signal peptide processing (GO:0006465)	2.65405733
92	GPI anchor metabolic process (GO:0006505)	2.65113798
93	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.64804928
94	ncRNA 3-end processing (GO:0043628)	2.60235278
95	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.60004732
96	recombinational repair (GO:0000725)	2.59632861
97	benzene-containing compound metabolic process (GO:0042537)	2.58846672
98	indole-containing compound metabolic process (GO:0042430)	2.57225938
99	GPI anchor biosynthetic process (GO:0006506)	2.56998981
100	seminiferous tubule development (GO:0072520)	2.56912703

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.02348934
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10962172
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67257363
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.40699031
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94092593
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85744753
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.74887402
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.61141700
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57287589
10	VDR_22108803_ChIP-Seq_LS180_Human	2.47981704
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.44623270
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40550076
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.30296075
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.19586975
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.12716185
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.06401444
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.97026680
18	EWS_26573619_Chip-Seq_HEK293_Human	1.90560284
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.83947584
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78559095
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77573902
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77111348
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.76941903
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.75244757
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70376013
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63885532
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62794412
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61830794
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61151615
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60369091
31	FUS_26573619_Chip-Seq_HEK293_Human	1.56992592
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.54354651
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52083042
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50269582
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50214442
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49755792
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47871204
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45764319
39	P300_19829295_ChIP-Seq_ESCs_Human	1.44424818
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43051124
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.42437533
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41398031
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40625675
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38589419
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30203776
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27662553
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27523950
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27371499
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27371499
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.23510872
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22222528
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18575982
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15693341
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.15354146
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14623040
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14436623
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14082994
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.13059098
59	AR_20517297_ChIP-Seq_VCAP_Human	1.11302486
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10683946
61	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.09867588
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07128693
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06491958
64	NCOR_22424771_ChIP-Seq_293T_Human	1.06167835
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05468540
66	RBPJ_21746931_ChIP-Seq_IB4_Human	1.05376200
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05269007
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04998667
69	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.04026782
70	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03607688
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03592333
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01604869
73	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00654630
74	AR_21572438_ChIP-Seq_LNCaP_Human	1.00508217
75	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99217432
76	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99217432
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99085449
78	CBP_20019798_ChIP-Seq_JUKART_Human	0.98547474
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98547474
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98142385
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97978173
82	GATA3_26560356_Chip-Seq_TH2_Human	0.97805514
83	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97528447
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.97352402
85	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.96465513
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96299419
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.95771137
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95614679
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95433722
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95335313
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94658667
92	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94400350
93	PHF8_20622853_ChIP-Seq_HELA_Human	0.93587041
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.92898078
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92015805
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.91901835
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91379112
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90851415
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.89537609
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88673908

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.65512975
2	MP0006292_abnormal_olfactory_placode	3.63456833
3	MP0008875_abnormal_xenobiotic_pharmacok	3.58773090
4	MP0005645_abnormal_hypothalamus_physiol	2.84967623
5	MP0008995_early_reproductive_senescence	2.66835011
6	MP0008872_abnormal_physiological_respon	2.52504690
7	MP0002736_abnormal_nociception_after	2.52077813
8	MP0008877_abnormal_DNA_methylation	2.45403963
9	MP0004142_abnormal_muscle_tone	2.34872870
10	MP0003786_premature_aging	2.24465749
11	MP0005551_abnormal_eye_electrophysiolog	2.20150758
12	MP0001968_abnormal_touch/_nociception	2.02489949
13	MP0006072_abnormal_retinal_apoptosis	1.99081491
14	MP0003195_calcinosis	1.96815580
15	MP0003693_abnormal_embryo_hatching	1.92731368
16	MP0000372_irregular_coat_pigmentation	1.88851430
17	MP0001986_abnormal_taste_sensitivity	1.85760874
18	MP0003646_muscle_fatigue	1.83183757
19	MP0002234_abnormal_pharynx_morphology	1.81598071
20	MP0008789_abnormal_olfactory_epithelium	1.78609093
21	MP0003011_delayed_dark_adaptation	1.77469243
22	MP0002138_abnormal_hepatobiliary_system	1.76742149
23	MP0003045_fibrosis	1.75994453
24	MP0004147_increased_porphyrin_level	1.73186891
25	MP0005253_abnormal_eye_physiology	1.66688095
26	MP0009379_abnormal_foot_pigmentation	1.65454691
27	MP0003136_yellow_coat_color	1.59118522
28	MP0001905_abnormal_dopamine_level	1.58214190
29	MP0003567_abnormal_fetal_cardiomyocyte	1.54557327
30	MP0000631_abnormal_neuroendocrine_gland	1.47837837
31	MP0004145_abnormal_muscle_electrophysio	1.46963606
32	MP0005671_abnormal_response_to	1.44852649
33	MP0002277_abnormal_respiratory_mucosa	1.42984611
34	MP0002095_abnormal_skin_pigmentation	1.38875055
35	MP0005084_abnormal_gallbladder_morpholo	1.35383326
36	MP0005410_abnormal_fertilization	1.35143329
37	MP0008058_abnormal_DNA_repair	1.31045449
38	MP0004215_abnormal_myocardial_fiber	1.30991424
39	MP0004133_heterotaxia	1.30270268
40	MP0001873_stomach_inflammation	1.29099151
41	MP0002638_abnormal_pupillary_reflex	1.28247436
42	MP0002837_dystrophic_cardiac_calcinosis	1.27360424
43	MP0002938_white_spotting	1.27130813
44	MP0000427_abnormal_hair_cycle	1.26811265
45	MP0002163_abnormal_gland_morphology	1.26722387
46	MP0001485_abnormal_pinna_reflex	1.24982845
47	MP0003787_abnormal_imprinting	1.24867683
48	MP0003186_abnormal_redox_activity	1.22445035
49	MP0006276_abnormal_autonomic_nervous	1.18070960
50	MP0003890_abnormal_embryonic-extraembry	1.15283977
51	MP0003718_maternal_effect	1.15210237
52	MP0002102_abnormal_ear_morphology	1.12817097
53	MP0005636_abnormal_mineral_homeostasis	1.12511098
54	MP0001293_anophthalmia	1.10938887
55	MP0009333_abnormal_splenocyte_physiolog	1.10564907
56	MP0002733_abnormal_thermal_nociception	1.08984973
57	MP0001348_abnormal_lacrimal_gland	1.06587397
58	MP0001970_abnormal_pain_threshold	1.00777546
59	MP0002272_abnormal_nervous_system	1.00276261
60	MP0000613_abnormal_salivary_gland	0.98644824
61	MP0005389_reproductive_system_phenotype	0.96160083
62	MP0005075_abnormal_melanosome_morpholog	0.94392659
63	MP0001661_extended_life_span	0.92348793
64	MP0001984_abnormal_olfaction	0.92199165
65	MP0001835_abnormal_antigen_presentation	0.91668363
66	MP0002184_abnormal_innervation	0.89837465
67	MP0000647_abnormal_sebaceous_gland	0.88532274
68	MP0001501_abnormal_sleep_pattern	0.88365835
69	MP0005394_taste/olfaction_phenotype	0.88009458
70	MP0005499_abnormal_olfactory_system	0.88009458
71	MP0002735_abnormal_chemical_nociception	0.87380283
72	MP0001919_abnormal_reproductive_system	0.86075867
73	MP0001529_abnormal_vocalization	0.85501016
74	MP0005083_abnormal_biliary_tract	0.85377463
75	MP0002067_abnormal_sensory_capabilities	0.85044516
76	MP0002166_altered_tumor_susceptibility	0.84019799
77	MP0009745_abnormal_behavioral_response	0.82076121
78	MP0001502_abnormal_circadian_rhythm	0.82024060
79	MP0002006_tumorigenesis	0.79213273
80	MP0004043_abnormal_pH_regulation	0.78995736
81	MP0005174_abnormal_tail_pigmentation	0.77878289
82	MP0005391_vision/eye_phenotype	0.77799354
83	MP0004885_abnormal_endolymph	0.77507267
84	MP0005195_abnormal_posterior_eye	0.76195488
85	MP0001764_abnormal_homeostasis	0.75223288
86	MP0002160_abnormal_reproductive_system	0.75113612
87	MP0009046_muscle_twitch	0.74825773
88	MP0002572_abnormal_emotion/affect_behav	0.74651406
89	MP0000049_abnormal_middle_ear	0.73749394
90	MP0003938_abnormal_ear_development	0.73151927
91	MP0001800_abnormal_humoral_immune	0.73054264
92	MP0002229_neurodegeneration	0.72818163
93	MP0001119_abnormal_female_reproductive	0.72638616
94	MP0003880_abnormal_central_pattern	0.72003283
95	MP0009785_altered_susceptibility_to	0.71520531
96	MP0005332_abnormal_amino_acid	0.70271008
97	MP0001324_abnormal_eye_pigmentation	0.69557180
98	MP0003137_abnormal_impulse_conducting	0.69397235
99	MP0006036_abnormal_mitochondrial_physio	0.68390745
100	MP0002132_abnormal_respiratory_system	0.67542148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	4.25873889
2	Methylmalonic acidemia (HP:0002912)	4.25525519
3	Type I transferrin isoform profile (HP:0003642)	3.93944309
4	Acute necrotizing encephalopathy (HP:0006965)	3.69036615
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.65096557
6	Hypochromic microcytic anemia (HP:0004840)	3.60728960
7	Abnormality of midbrain morphology (HP:0002418)	3.53178917
8	Molar tooth sign on MRI (HP:0002419)	3.53178917
9	Methylmalonic aciduria (HP:0012120)	3.46219449
10	Renal cortical cysts (HP:0000803)	3.36691967
11	Hypoproteinemia (HP:0003075)	3.30774879
12	Acute encephalopathy (HP:0006846)	3.26578234
13	Pancreatic cysts (HP:0001737)	3.26012647
14	Mitochondrial inheritance (HP:0001427)	3.21151488
15	Pancreatic fibrosis (HP:0100732)	3.18293111
16	Increased CSF lactate (HP:0002490)	3.14207165
17	Abnormality of the pons (HP:0007361)	3.12969459
18	Hypoplasia of the pons (HP:0012110)	3.05646890
19	Nephronophthisis (HP:0000090)	3.04093240
20	Hepatocellular necrosis (HP:0001404)	3.03305877
21	Progressive macrocephaly (HP:0004481)	3.02486467
22	Congenital stationary night blindness (HP:0007642)	2.99548671
23	Abnormality of the renal cortex (HP:0011035)	2.98823550
24	Thyroid-stimulating hormone excess (HP:0002925)	2.92055921
25	True hermaphroditism (HP:0010459)	2.81760734
26	Hepatic necrosis (HP:0002605)	2.80902880
27	Congenital, generalized hypertrichosis (HP:0004540)	2.77542715
28	Abnormal protein glycosylation (HP:0012346)	2.74187704
29	Abnormal glycosylation (HP:0012345)	2.74187704
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.74187704
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.74187704
32	Abnormality of alanine metabolism (HP:0010916)	2.73760943
33	Hyperalaninemia (HP:0003348)	2.73760943
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73760943
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.73176406
36	Increased intramyocellular lipid droplets (HP:0012240)	2.70698662
37	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.61595062
38	Abnormality of DNA repair (HP:0003254)	2.53738000
39	Abnormality of the ileum (HP:0001549)	2.53359358
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.51465455
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.51465455
42	Asplenia (HP:0001746)	2.49106344
43	Abnormality of the renal medulla (HP:0100957)	2.47645651
44	Absent thumb (HP:0009777)	2.43409335
45	Large for gestational age (HP:0001520)	2.41895479
46	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.40576250
47	Meckel diverticulum (HP:0002245)	2.38879642
48	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.34623302
49	IgG deficiency (HP:0004315)	2.33616714
50	Increased hepatocellular lipid droplets (HP:0006565)	2.28693951
51	Cerebral edema (HP:0002181)	2.28033291
52	Stomatitis (HP:0010280)	2.25232079
53	Lactic acidosis (HP:0003128)	2.19096109
54	Optic disc pallor (HP:0000543)	2.15511643
55	Abnormality of vitamin B metabolism (HP:0004340)	2.13174875
56	Cystic liver disease (HP:0006706)	2.10893783
57	Increased serum lactate (HP:0002151)	2.07256684
58	Abolished electroretinogram (ERG) (HP:0000550)	2.06853203
59	Adrenal hypoplasia (HP:0000835)	2.06239323
60	Increased muscle lipid content (HP:0009058)	2.06152204
61	Hyperglycinemia (HP:0002154)	2.04662094
62	Abnormality of the preputium (HP:0100587)	2.04414492
63	Abnormality of macular pigmentation (HP:0008002)	2.03179769
64	Medial flaring of the eyebrow (HP:0010747)	2.03024653
65	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.02253945
66	Sclerocornea (HP:0000647)	1.99793315
67	Respiratory failure (HP:0002878)	1.99697879
68	Lipid accumulation in hepatocytes (HP:0006561)	1.98970442
69	Anencephaly (HP:0002323)	1.94568638
70	Renal Fanconi syndrome (HP:0001994)	1.94336667
71	Lethargy (HP:0001254)	1.94335553
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91656273
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91329858
74	Clubbing of toes (HP:0100760)	1.89663675
75	CNS demyelination (HP:0007305)	1.89306378
76	Type 2 muscle fiber atrophy (HP:0003554)	1.88749942
77	3-Methylglutaconic aciduria (HP:0003535)	1.88478624
78	Elevated erythrocyte sedimentation rate (HP:0003565)	1.88368382
79	Abnormality of chromosome stability (HP:0003220)	1.86110464
80	Poor head control (HP:0002421)	1.85603701
81	Dicarboxylic aciduria (HP:0003215)	1.83330532
82	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.83330532
83	Tubulointerstitial nephritis (HP:0001970)	1.81433484
84	Reticulocytopenia (HP:0001896)	1.81199317
85	Leukodystrophy (HP:0002415)	1.80600879
86	Ketosis (HP:0001946)	1.78355576
87	Nephrogenic diabetes insipidus (HP:0009806)	1.77565138
88	Intestinal atresia (HP:0011100)	1.76343885
89	Concave nail (HP:0001598)	1.75838182
90	Chromsome breakage (HP:0040012)	1.75766089
91	Triphalangeal thumb (HP:0001199)	1.73731459
92	Postaxial foot polydactyly (HP:0001830)	1.72375052
93	Oligohydramnios (HP:0001562)	1.71951194
94	Neutropenia (HP:0001875)	1.71401468
95	Lissencephaly (HP:0001339)	1.70936962
96	Supernumerary spleens (HP:0009799)	1.70405130
97	Exercise intolerance (HP:0003546)	1.67117134
98	Colon cancer (HP:0003003)	1.66943071
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.66831154
100	Abnormal drinking behavior (HP:0030082)	1.65924184

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.62227845
2	STK16	3.00824870
3	TXK	2.68561851
4	TLK1	2.66301872
5	SCYL2	2.66006480
6	MAP4K2	2.40870514
7	STK38L	2.40868474
8	FRK	2.24454100
9	VRK2	2.22976513
10	NUAK1	2.15429775
11	EIF2AK3	2.08594787
12	NME1	2.06782364
13	STK24	1.93220608
14	MST4	1.92838563
15	ADRBK2	1.81987598
16	TSSK6	1.77482379
17	BMPR1B	1.76418224
18	GRK1	1.66577190
19	CDK19	1.63687644
20	PBK	1.63472746
21	ZAK	1.60515733
22	BCKDK	1.48566962
23	NEK1	1.44995490
24	BUB1	1.38104323
25	VRK1	1.34722636
26	MAPK13	1.32909597
27	TAOK3	1.31702210
28	PLK2	1.29074988
29	PLK3	1.21211211
30	OXSR1	1.18874793
31	MAP4K1	1.14818988
32	MKNK1	1.14567937
33	MARK1	1.08861315
34	TIE1	1.08475936
35	CAMKK2	1.08470002
36	TNK2	1.06837680
37	PHKG2	1.04820362
38	PHKG1	1.04820362
39	WNK4	1.04576277
40	WNK3	1.03861242
41	GRK7	0.90787866
42	TAF1	0.90033003
43	CSNK1G2	0.89471781
44	MAPKAPK3	0.86757334
45	PLK4	0.82986663
46	INSRR	0.82815903
47	NEK9	0.81419162
48	PINK1	0.81395680
49	MAP2K6	0.81051976
50	MINK1	0.79290513
51	MKNK2	0.79031690
52	KDR	0.79006305
53	CSNK1G3	0.75250693
54	ADRBK1	0.74721080
55	PRKCI	0.74174342
56	PRKCQ	0.73614483
57	EIF2AK2	0.73550413
58	DYRK2	0.71178701
59	MAPKAPK5	0.70389236
60	STK39	0.68571233
61	NEK6	0.66985394
62	SYK	0.66287225
63	PRKCE	0.64645025
64	KIT	0.60026924
65	PRKCG	0.59191074
66	ERBB3	0.51517539
67	CLK1	0.51061183
68	AURKA	0.50795645
69	NTRK2	0.50533052
70	TNIK	0.49767332
71	PLK1	0.49633222
72	PRKACA	0.48961088
73	CDC7	0.48450495
74	CSNK1G1	0.47869825
75	CSNK1A1L	0.46168666
76	CAMK2A	0.45933325
77	TEC	0.45665960
78	GRK5	0.45177095
79	PAK3	0.43021016
80	WNK1	0.41207967
81	CSNK2A2	0.40937959
82	IKBKB	0.40911560
83	BTK	0.40598756
84	CSNK2A1	0.40352189
85	IKBKE	0.40041865
86	EPHB2	0.39917469
87	SRPK1	0.39643335
88	PRKCA	0.37267570
89	PIK3CA	0.36940447
90	RPS6KA5	0.35817788
91	ITK	0.35038944
92	BRSK1	0.34980943
93	CHEK2	0.33676824
94	MAP2K7	0.33254012
95	CAMK2D	0.32846160
96	PRKACG	0.32658139
97	BCR	0.32090412
98	PIK3CG	0.32022831
99	ATR	0.30745282
100	OBSCN	0.30202704

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.71188411
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89192383
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.80116832
4	Ribosome_Homo sapiens_hsa03010	2.44451912
5	Homologous recombination_Homo sapiens_hsa03440	2.36499601
6	Parkinsons disease_Homo sapiens_hsa05012	2.24188048
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22593786
8	Mismatch repair_Homo sapiens_hsa03430	2.15499630
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.15285377
10	One carbon pool by folate_Homo sapiens_hsa00670	2.12902031
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.10058178
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05623174
13	Protein export_Homo sapiens_hsa03060	2.03996880
14	Propanoate metabolism_Homo sapiens_hsa00640	2.01578687
15	Butanoate metabolism_Homo sapiens_hsa00650	1.88547183
16	RNA polymerase_Homo sapiens_hsa03020	1.87261306
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.83036272
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.81073263
19	Fatty acid elongation_Homo sapiens_hsa00062	1.76060257
20	DNA replication_Homo sapiens_hsa03030	1.70358315
21	Phototransduction_Homo sapiens_hsa04744	1.68573787
22	Huntingtons disease_Homo sapiens_hsa05016	1.60963667
23	Base excision repair_Homo sapiens_hsa03410	1.59515564
24	Peroxisome_Homo sapiens_hsa04146	1.53137462
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52586063
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46855022
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.45215703
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44510304
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42349337
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.42298460
31	Alzheimers disease_Homo sapiens_hsa05010	1.38373067
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.38265262
33	Fatty acid degradation_Homo sapiens_hsa00071	1.35118975
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.31415214
35	Asthma_Homo sapiens_hsa05310	1.30131477
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23075084
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.22703712
38	Folate biosynthesis_Homo sapiens_hsa00790	1.22537236
39	RNA degradation_Homo sapiens_hsa03018	1.18130453
40	Basal transcription factors_Homo sapiens_hsa03022	1.13394197
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.09109069
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09077122
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08240785
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06818106
45	Purine metabolism_Homo sapiens_hsa00230	1.02348217
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99260696
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.95966508
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.94523435
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93832093
50	RNA transport_Homo sapiens_hsa03013	0.93565758
51	Spliceosome_Homo sapiens_hsa03040	0.91552112
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.91537905
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91382079
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91044787
55	Allograft rejection_Homo sapiens_hsa05330	0.90339924
56	Caffeine metabolism_Homo sapiens_hsa00232	0.88278147
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86379304
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.86132591
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86098229
60	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.85264283
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84998246
62	Retinol metabolism_Homo sapiens_hsa00830	0.84235792
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82101421
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.81954963
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80478744
66	Metabolic pathways_Homo sapiens_hsa01100	0.76868712
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76806994
68	Glutathione metabolism_Homo sapiens_hsa00480	0.75947668
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72891472
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71941028
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71738319
72	Olfactory transduction_Homo sapiens_hsa04740	0.68551011
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.67459705
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.65330700
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64856880
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.64537823
77	Histidine metabolism_Homo sapiens_hsa00340	0.56112071
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55994897
79	Sulfur metabolism_Homo sapiens_hsa00920	0.55677962
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55661907
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.52710490
82	Salivary secretion_Homo sapiens_hsa04970	0.51240341
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46431903
84	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46071022
85	ABC transporters_Homo sapiens_hsa02010	0.44696091
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44412386
87	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40243569
88	Insulin secretion_Homo sapiens_hsa04911	0.38087561
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37851661
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37767445
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36853577
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35913002
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35574861
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35442306
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34938679
96	Sulfur relay system_Homo sapiens_hsa04122	0.33578960
97	Morphine addiction_Homo sapiens_hsa05032	0.31489348
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31047561
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.30801298
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30027123

HMGB1P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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