ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of RIG-I signaling pathway (GO:0039535)	6.69744077
2	protein polyglutamylation (GO:0018095)	6.63236002
3	regulation of interleukin-5 production (GO:0032674)	6.28016042
4	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.92321428
5	microtubule polymerization or depolymerization (GO:0031109)	4.91151484
6	response to pheromone (GO:0019236)	4.71766353
7	sperm motility (GO:0030317)	4.70638737
8	positive regulation of glycolytic process (GO:0045821)	4.50120585
9	positive regulation of macrophage activation (GO:0043032)	4.49537622
10	positive regulation of T cell cytokine production (GO:0002726)	4.49152032
11	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	4.33157365
12	rRNA methylation (GO:0031167)	4.32510177
13	acrosome reaction (GO:0007340)	4.10927249
14	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.95115883
15	peptidyl-threonine dephosphorylation (GO:0035970)	3.93921756
16	mRNA cleavage (GO:0006379)	3.92948699
17	positive regulation of T cell chemotaxis (GO:0010820)	3.92292441
18	regulation of T cell chemotaxis (GO:0010819)	3.92292441
19	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.91660711
20	pre-miRNA processing (GO:0031054)	3.91030873
21	monoubiquitinated protein deubiquitination (GO:0035520)	3.90530775
22	regulation of sarcomere organization (GO:0060297)	3.87365246
23	regulation of cilium movement (GO:0003352)	3.78132110
24	positive regulation of immunoglobulin production (GO:0002639)	3.77442611
25	cellular response to interleukin-15 (GO:0071350)	3.76282128
26	piRNA metabolic process (GO:0034587)	3.73228134
27	protein K48-linked deubiquitination (GO:0071108)	3.71535715
28	positive regulation of fibroblast migration (GO:0010763)	3.69941291
29	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.68832692
30	sperm-egg recognition (GO:0035036)	3.65732288
31	negative regulation of heart rate (GO:0010459)	3.60849545
32	negative regulation of T cell mediated immunity (GO:0002710)	3.60485642
33	gonadal mesoderm development (GO:0007506)	3.53293449
34	rRNA modification (GO:0000154)	3.52839036
35	cellular ketone body metabolic process (GO:0046950)	3.50422875
36	nucleoside diphosphate catabolic process (GO:0009134)	3.45153793
37	positive regulation of granulocyte differentiation (GO:0030854)	3.38539743
38	regulation of T cell cytokine production (GO:0002724)	3.37056639
39	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.36299567
40	positive regulation of type 2 immune response (GO:0002830)	3.30654910
41	activated T cell proliferation (GO:0050798)	3.30432689
42	cAMP catabolic process (GO:0006198)	3.29687641
43	microtubule depolymerization (GO:0007019)	3.27139727
44	regulation of protein kinase A signaling (GO:0010738)	3.27105720
45	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.26646077
46	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.26646077
47	regulation of translation, ncRNA-mediated (GO:0045974)	3.26646077
48	fucose catabolic process (GO:0019317)	3.26281265
49	L-fucose metabolic process (GO:0042354)	3.26281265
50	L-fucose catabolic process (GO:0042355)	3.26281265
51	cell-cell recognition (GO:0009988)	3.25992233
52	binding of sperm to zona pellucida (GO:0007339)	3.24601108
53	regulation of centriole replication (GO:0046599)	3.23208272
54	response to interleukin-15 (GO:0070672)	3.21970627
55	detection of light stimulus involved in visual perception (GO:0050908)	3.21557792
56	detection of light stimulus involved in sensory perception (GO:0050962)	3.21557792
57	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.19399278
58	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	3.17044203
59	NAD biosynthetic process (GO:0009435)	3.11778153
60	axoneme assembly (GO:0035082)	3.10496905
61	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.10162801
62	lymphocyte chemotaxis (GO:0048247)	3.08780285
63	tyrosine phosphorylation of STAT protein (GO:0007260)	3.06858062
64	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.05914014
65	microtubule severing (GO:0051013)	3.05686872
66	nerve growth factor signaling pathway (GO:0038180)	3.05248449
67	positive regulation of cell killing (GO:0031343)	3.03774796
68	ketone body metabolic process (GO:1902224)	3.03257303
69	regulation of alpha-beta T cell proliferation (GO:0046640)	3.03080758
70	negative regulation of interleukin-2 production (GO:0032703)	3.01193785
71	fusion of sperm to egg plasma membrane (GO:0007342)	3.01125576
72	positive regulation of hormone biosynthetic process (GO:0046886)	3.00280401
73	centriole replication (GO:0007099)	2.98380519
74	auditory receptor cell stereocilium organization (GO:0060088)	2.94800364
75	response to misfolded protein (GO:0051788)	2.93362979
76	reflex (GO:0060004)	2.92914963
77	phosphorelay signal transduction system (GO:0000160)	2.90382420
78	regulation of memory T cell differentiation (GO:0043380)	2.90120944
79	nephron epithelium morphogenesis (GO:0072088)	2.89892227
80	nephron tubule morphogenesis (GO:0072078)	2.89892227
81	regulation of regulatory T cell differentiation (GO:0045589)	2.89737977
82	positive regulation of T-helper 1 type immune response (GO:0002827)	2.86544075
83	regulation of immunoglobulin production (GO:0002637)	2.80962133
84	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.78016160
85	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.77107728
86	regulation of female gonad development (GO:2000194)	2.76983535
87	multicellular organism reproduction (GO:0032504)	2.74891566
88	dendritic spine morphogenesis (GO:0060997)	2.74620024
89	single strand break repair (GO:0000012)	2.73935991
90	cyclic nucleotide catabolic process (GO:0009214)	2.73816733
91	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.73319149
92	microtubule nucleation (GO:0007020)	2.72674285
93	interkinetic nuclear migration (GO:0022027)	2.72283002
94	proline transport (GO:0015824)	2.71360428
95	NIK/NF-kappaB signaling (GO:0038061)	2.68834500
96	spermatid development (GO:0007286)	2.68697573
97	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.68102935
98	regulation of lymphocyte chemotaxis (GO:1901623)	2.68088110
99	behavioral response to nicotine (GO:0035095)	2.67264155
100	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.67158224

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.28070285
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.89087080
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.48772126
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.61806089
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73611336
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.66499106
7	VDR_22108803_ChIP-Seq_LS180_Human	2.65876318
8	DROSHA_22980978_ChIP-Seq_HELA_Human	2.47451960
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.29406360
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23661367
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.08782210
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03754918
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.03754918
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.02141875
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.01169905
16	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.93463601
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85907958
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72181160
19	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.69654716
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.66134169
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.63081895
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.61667276
23	STAT3_23295773_ChIP-Seq_U87_Human	1.55373076
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.53517588
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50504214
26	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49336203
27	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.48070286
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43757797
29	P300_19829295_ChIP-Seq_ESCs_Human	1.43190392
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41540390
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40154184
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38080950
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36013643
34	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.33523661
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.32975606
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.32291746
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32291746
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32243930
39	OCT4_20526341_ChIP-Seq_ESCs_Human	1.31506559
40	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.31446964
41	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.28078169
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27532105
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25212517
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.24049667
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22710524
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22234989
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20178120
48	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.19957783
49	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18617551
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17192784
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17172388
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17064586
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16636005
54	TCF4_23295773_ChIP-Seq_U87_Human	1.16436034
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16116107
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15846673
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15246407
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14848742
59	SMRT_27268052_Chip-Seq_Bcells_Human	1.13912994
60	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.13587456
61	ERA_21632823_ChIP-Seq_H3396_Human	1.10055550
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07411867
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06820596
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03937480
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.03694233
66	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03329972
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02928725
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00894797
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00894797
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00419719
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00227148
72	BCAT_22108803_ChIP-Seq_LS180_Human	0.99787909
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98949369
74	AR_25329375_ChIP-Seq_VCAP_Human	0.98191219
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97339776
76	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.97134050
77	FUS_26573619_Chip-Seq_HEK293_Human	0.95041601
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94390517
79	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93961809
80	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93956266
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93710248
82	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.93637557
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.93287477
84	MYB_26560356_Chip-Seq_TH2_Human	0.93221376
85	GATA3_26560356_Chip-Seq_TH1_Human	0.92692325
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92482350
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92312689
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92117289
89	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.91457469
90	KDM2B_26808549_Chip-Seq_REH_Human	0.90641910
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90537109
92	E2F1_20622854_ChIP-Seq_HELA_Human	0.89748594
93	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.89575073
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88682216
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88682216
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.88105071
97	GATA3_26560356_Chip-Seq_TH2_Human	0.87880139
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87433538
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.86730282
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86436865

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001348_abnormal_lacrimal_gland	4.01725446
2	MP0003045_fibrosis	3.34431955
3	MP0005410_abnormal_fertilization	3.21757979
4	MP0005423_abnormal_somatic_nervous	3.12156839
5	MP0006276_abnormal_autonomic_nervous	2.94543579
6	MP0003878_abnormal_ear_physiology	2.88048090
7	MP0005377_hearing/vestibular/ear_phenot	2.88048090
8	MP0001501_abnormal_sleep_pattern	2.76813987
9	MP0002822_catalepsy	2.71207328
10	MP0005310_abnormal_salivary_gland	2.55920768
11	MP0003646_muscle_fatigue	2.49285643
12	MP0005670_abnormal_white_adipose	2.44418269
13	MP0005379_endocrine/exocrine_gland_phen	2.32089037
14	MP0002735_abnormal_chemical_nociception	2.30549270
15	MP0003880_abnormal_central_pattern	2.29218644
16	MP0001790_abnormal_immune_system	2.26474111
17	MP0005387_immune_system_phenotype	2.26474111
18	MP0005671_abnormal_response_to	2.21522572
19	MP0000372_irregular_coat_pigmentation	2.20283823
20	MP0001873_stomach_inflammation	1.92574007
21	MP0001835_abnormal_antigen_presentation	1.87578433
22	MP0009745_abnormal_behavioral_response	1.86151306
23	MP0005551_abnormal_eye_electrophysiolog	1.71571521
24	MP0002734_abnormal_mechanical_nocicepti	1.68476632
25	MP0009333_abnormal_splenocyte_physiolog	1.68219951
26	MP0000569_abnormal_digit_pigmentation	1.67419978
27	MP0001905_abnormal_dopamine_level	1.66148831
28	MP0001968_abnormal_touch/_nociception	1.64681287
29	MP0004270_analgesia	1.56240535
30	MP0002163_abnormal_gland_morphology	1.56054036
31	MP0002572_abnormal_emotion/affect_behav	1.55495241
32	MP0002733_abnormal_thermal_nociception	1.51665606
33	MP0001970_abnormal_pain_threshold	1.50528720
34	MP0003866_abnormal_defecation	1.50200722
35	MP0003698_abnormal_male_reproductive	1.49105191
36	MP0009046_muscle_twitch	1.48566328
37	MP0001800_abnormal_humoral_immune	1.46654794
38	MP0002653_abnormal_ependyma_morphology	1.45324014
39	MP0003195_calcinosis	1.44208793
40	MP0002168_other_aberrant_phenotype	1.41104030
41	MP0002138_abnormal_hepatobiliary_system	1.36170466
42	MP0001486_abnormal_startle_reflex	1.32505944
43	MP0000685_abnormal_immune_system	1.31686998
44	MP0009785_altered_susceptibility_to	1.30535775
45	MP0008877_abnormal_DNA_methylation	1.25992668
46	MP0002067_abnormal_sensory_capabilities	1.25011940
47	MP0002234_abnormal_pharynx_morphology	1.21485949
48	MP0004742_abnormal_vestibular_system	1.19514543
49	MP0002272_abnormal_nervous_system	1.18941157
50	MP0004381_abnormal_hair_follicle	1.17533582
51	MP0003635_abnormal_synaptic_transmissio	1.13159147
52	MP0002723_abnormal_immune_serum	1.08621880
53	MP0001929_abnormal_gametogenesis	1.02217272
54	MP0003724_increased_susceptibility_to	1.01525726
55	MP0002693_abnormal_pancreas_physiology	1.00232802
56	MP0005451_abnormal_body_composition	1.00049883
57	MP0002557_abnormal_social/conspecific_i	0.99996294
58	MP0006072_abnormal_retinal_apoptosis	0.97849249
59	MP0004142_abnormal_muscle_tone	0.96762718
60	MP0002064_seizures	0.95588169
61	MP0001963_abnormal_hearing_physiology	0.94809794
62	MP0004043_abnormal_pH_regulation	0.94708238
63	MP0001984_abnormal_olfaction	0.94679723
64	MP0001440_abnormal_grooming_behavior	0.93494756
65	MP0005167_abnormal_blood-brain_barrier	0.92402256
66	MP0005025_abnormal_response_to	0.92344389
67	MP0008872_abnormal_physiological_respon	0.90166134
68	MP0005395_other_phenotype	0.89551775
69	MP0002063_abnormal_learning/memory/cond	0.89131629
70	MP0002736_abnormal_nociception_after	0.87775897
71	MP0000015_abnormal_ear_pigmentation	0.87099119
72	MP0004859_abnormal_synaptic_plasticity	0.86967534
73	MP0003763_abnormal_thymus_physiology	0.85679804
74	MP0001485_abnormal_pinna_reflex	0.85360410
75	MP0002102_abnormal_ear_morphology	0.85248607
76	MP0005000_abnormal_immune_tolerance	0.84270974
77	MP0004147_increased_porphyrin_level	0.83946607
78	MP0000470_abnormal_stomach_morphology	0.83370708
79	MP0010386_abnormal_urinary_bladder	0.82991816
80	MP0005075_abnormal_melanosome_morpholog	0.82952274
81	MP0006082_CNS_inflammation	0.80734776
82	MP0002184_abnormal_innervation	0.78534831
83	MP0003303_peritoneal_inflammation	0.77758238
84	MP0004510_myositis	0.77512540
85	MP0005584_abnormal_enzyme/coenzyme_acti	0.77494977
86	MP0002254_reproductive_system_inflammat	0.75706859
87	MP0002876_abnormal_thyroid_physiology	0.75533501
88	MP0002210_abnormal_sex_determination	0.75140386
89	MP0002229_neurodegeneration	0.74867658
90	MP0002452_abnormal_antigen_presenting	0.74719642
91	MP0002161_abnormal_fertility/fecundity	0.73468108
92	MP0002751_abnormal_autonomic_nervous	0.73277875
93	MP0004133_heterotaxia	0.72848880
94	MP0000716_abnormal_immune_system	0.72350010
95	MP0002277_abnormal_respiratory_mucosa	0.72053955
96	MP0002420_abnormal_adaptive_immunity	0.71926841
97	MP0000026_abnormal_inner_ear	0.71113391
98	MP0005645_abnormal_hypothalamus_physiol	0.70690182
99	MP0005253_abnormal_eye_physiology	0.69071864
100	MP0001853_heart_inflammation	0.68594151

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	6.85554554
2	Severe visual impairment (HP:0001141)	4.94319556
3	Progressive cerebellar ataxia (HP:0002073)	4.88357779
4	Molar tooth sign on MRI (HP:0002419)	4.49537365
5	Abnormality of midbrain morphology (HP:0002418)	4.49537365
6	Retinal dysplasia (HP:0007973)	3.99829652
7	Urinary bladder sphincter dysfunction (HP:0002839)	3.91782346
8	Dysmetric saccades (HP:0000641)	3.65083072
9	IgM deficiency (HP:0002850)	3.38307517
10	Nephronophthisis (HP:0000090)	3.38048448
11	Gaze-evoked nystagmus (HP:0000640)	3.36985841
12	Autoimmune thrombocytopenia (HP:0001973)	3.19566408
13	Abnormality of macular pigmentation (HP:0008002)	3.05442805
14	Congenital stationary night blindness (HP:0007642)	3.03288591
15	Attenuation of retinal blood vessels (HP:0007843)	3.00905117
16	Fetal akinesia sequence (HP:0001989)	2.99754031
17	Abnormality of the renal cortex (HP:0011035)	2.99475485
18	Abnormality of the renal medulla (HP:0100957)	2.98448251
19	Abnormality of T cell number (HP:0011839)	2.96797066
20	Renal cortical cysts (HP:0000803)	2.96590764
21	Impaired smooth pursuit (HP:0007772)	2.96265317
22	T lymphocytopenia (HP:0005403)	2.90492547
23	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.82991386
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.78555917
25	Chronic diarrhea (HP:0002028)	2.69791668
26	Proximal tubulopathy (HP:0000114)	2.69189320
27	Dysautonomia (HP:0002459)	2.69019285
28	Hyperkalemia (HP:0002153)	2.68227961
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.65733147
30	Absent/shortened dynein arms (HP:0200106)	2.61739384
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.61739384
32	Pendular nystagmus (HP:0012043)	2.59085746
33	Hypoplasia of the pons (HP:0012110)	2.59050806
34	Type 2 muscle fiber atrophy (HP:0003554)	2.54075852
35	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.51390448
36	Decreased central vision (HP:0007663)	2.50091790
37	Abnormality of the labia minora (HP:0012880)	2.47940058
38	Narrow nasal bridge (HP:0000446)	2.46914310
39	Pancreatic cysts (HP:0001737)	2.45158669
40	Abnormality of T cells (HP:0002843)	2.45011476
41	IgG deficiency (HP:0004315)	2.44473411
42	Abnormal ciliary motility (HP:0012262)	2.42753776
43	Abnormality of the diencephalon (HP:0010662)	2.39690421
44	Spinal muscular atrophy (HP:0007269)	2.37457214
45	Abnormality of the pons (HP:0007361)	2.35344459
46	Tubulointerstitial nephritis (HP:0001970)	2.35025911
47	Tubular atrophy (HP:0000092)	2.31516440
48	Inability to walk (HP:0002540)	2.29615340
49	Abnormality of T cell physiology (HP:0011840)	2.28240964
50	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.26788705
51	Sclerocornea (HP:0000647)	2.26004043
52	Carpal bone hypoplasia (HP:0001498)	2.18887933
53	Short tibia (HP:0005736)	2.15638808
54	Progressive inability to walk (HP:0002505)	2.15382669
55	Hypoplastic ischia (HP:0003175)	2.13706847
56	IgA deficiency (HP:0002720)	2.13367541
57	Abnormal albumin level (HP:0012116)	2.08315227
58	Hypoalbuminemia (HP:0003073)	2.08315227
59	Muscle fiber atrophy (HP:0100295)	2.07027388
60	Hyperventilation (HP:0002883)	2.03626619
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.01565501
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01565501
63	Enlarged epiphyses (HP:0010580)	2.01466415
64	Impaired vibratory sensation (HP:0002495)	2.00692214
65	Hypoproteinemia (HP:0003075)	2.00233277
66	Diplopia (HP:0000651)	1.99291801
67	Abnormality of binocular vision (HP:0011514)	1.99291801
68	Tachypnea (HP:0002789)	1.95608117
69	Abnormality of DNA repair (HP:0003254)	1.95564580
70	Volvulus (HP:0002580)	1.90628493
71	Nasal polyposis (HP:0100582)	1.89814993
72	Pancreatic fibrosis (HP:0100732)	1.89392581
73	Bell-shaped thorax (HP:0001591)	1.88750667
74	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87973804
75	Abnormality of ocular smooth pursuit (HP:0000617)	1.87538035
76	Absent speech (HP:0001344)	1.87495443
77	Autoimmune hemolytic anemia (HP:0001890)	1.86919009
78	Duplicated collecting system (HP:0000081)	1.86264861
79	Broad-based gait (HP:0002136)	1.84548922
80	Polyuria (HP:0000103)	1.83120358
81	Chronic hepatic failure (HP:0100626)	1.83022873
82	3-Methylglutaconic aciduria (HP:0003535)	1.81924578
83	True hermaphroditism (HP:0010459)	1.79809430
84	Abnormal urine output (HP:0012590)	1.79118005
85	Arthropathy (HP:0003040)	1.79051516
86	Abnormality of potassium homeostasis (HP:0011042)	1.78042371
87	Lissencephaly (HP:0001339)	1.77988242
88	Focal motor seizures (HP:0011153)	1.77253203
89	Abnormality of dental color (HP:0011073)	1.76010759
90	Abnormality of the renal collecting system (HP:0004742)	1.75857825
91	Autoamputation (HP:0001218)	1.75805872
92	Ectopic kidney (HP:0000086)	1.75751197
93	Protruding tongue (HP:0010808)	1.73929999
94	Medial flaring of the eyebrow (HP:0010747)	1.72602475
95	Highly arched eyebrow (HP:0002553)	1.70936862
96	Chronic bronchitis (HP:0004469)	1.69906159
97	Stomatitis (HP:0010280)	1.67501720
98	Optic neuritis (HP:0100653)	1.66656168
99	Retrobulbar optic neuritis (HP:0100654)	1.66656168
100	Intellectual disability, moderate (HP:0002342)	1.66221457

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	5.43453627
2	LATS1	5.02843294
3	NUAK1	4.74502904
4	TXK	4.28098854
5	FRK	3.91196704
6	INSRR	2.93177022
7	FES	2.42342906
8	NEK1	2.23449637
9	MATK	2.13978911
10	WNK4	2.08089986
11	TAOK1	1.98612577
12	MST4	1.90737905
13	ADRBK2	1.88629974
14	MAP3K11	1.85047779
15	MAPKAPK3	1.72739758
16	SIK2	1.67407603
17	NTRK1	1.64906770
18	NLK	1.63500103
19	MAP4K2	1.60618831
20	PLK2	1.56343361
21	MARK1	1.51474757
22	NEK2	1.43780494
23	TAOK2	1.34571807
24	CSNK1A1L	1.32827666
25	TNK2	1.31756657
26	CSNK1G3	1.29585652
27	CSNK1G2	1.26732757
28	DAPK2	1.21319421
29	ITK	1.19985693
30	DAPK1	1.19939770
31	MAP4K1	1.13581890
32	MAP3K4	1.07965162
33	CASK	1.05011436
34	FER	1.01271211
35	MAPK11	1.00712259
36	MAP2K6	0.98402203
37	DDR2	0.96731794
38	STK3	0.93963292
39	PASK	0.93703915
40	NME1	0.88732986
41	CSNK1G1	0.83992998
42	VRK2	0.82938207
43	TSSK6	0.82174887
44	GRK1	0.80836092
45	TAF1	0.80309080
46	MAPK13	0.78095304
47	MAP3K3	0.75038361
48	WNK3	0.73344032
49	PRKCE	0.68744599
50	STK39	0.68171242
51	LCK	0.66621282
52	WNK1	0.63900948
53	MAP2K3	0.62621519
54	BUB1	0.60880688
55	PRKCQ	0.58446222
56	NEK9	0.57988103
57	BTK	0.54851141
58	TAOK3	0.54073336
59	CSNK1A1	0.52994425
60	PTK2B	0.50433109
61	GRK7	0.49250495
62	VRK1	0.46754962
63	CAMK1G	0.45910455
64	GRK5	0.43530632
65	HCK	0.43246497
66	SIK3	0.43174670
67	CSK	0.41898431
68	CAMK1D	0.41856636
69	TEC	0.41207672
70	JAK3	0.40643618
71	PRKCG	0.40518130
72	MARK3	0.38327709
73	RPS6KA4	0.37755420
74	TYK2	0.36777478
75	CAMK2A	0.36711000
76	KIT	0.35439484
77	MAPKAPK5	0.34951486
78	IKBKB	0.34943466
79	ACVR1B	0.34247738
80	DYRK2	0.34208169
81	PRKCH	0.33814862
82	PINK1	0.32056661
83	MAP3K12	0.32043090
84	PRKCB	0.31367784
85	ADRBK1	0.30454914
86	RIPK4	0.29003741
87	GSK3B	0.28172523
88	PRKG1	0.27293224
89	ERBB2	0.27258255
90	PRKAA2	0.27235812
91	TYRO3	0.26533970
92	MAP3K7	0.25844068
93	EIF2AK2	0.25444320
94	YES1	0.25102342
95	ALK	0.24840398
96	CDK3	0.23911330
97	SYK	0.23528951
98	CAMKK1	0.22876033
99	STK38L	0.21852561
100	BRD4	0.21373371

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.76611594
2	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.99891100
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.80828234
4	Allograft rejection_Homo sapiens_hsa05330	2.77598985
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.58105427
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.52950039
7	Nicotine addiction_Homo sapiens_hsa05033	2.52738720
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.41479642
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32237738
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.32210884
11	Morphine addiction_Homo sapiens_hsa05032	2.20292673
12	Jak-STAT signaling pathway_Homo sapiens_hsa04630	2.08989467
13	Taste transduction_Homo sapiens_hsa04742	2.08363150
14	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	2.06743213
15	Primary immunodeficiency_Homo sapiens_hsa05340	2.00417679
16	Butanoate metabolism_Homo sapiens_hsa00650	1.90804469
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89800251
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89397529
19	Measles_Homo sapiens_hsa05162	1.81694322
20	GABAergic synapse_Homo sapiens_hsa04727	1.71325080
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71113491
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.65115600
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.60542121
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56150558
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51125383
26	One carbon pool by folate_Homo sapiens_hsa00670	1.50447217
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47499588
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.45427536
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.42594563
30	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.37967481
31	Olfactory transduction_Homo sapiens_hsa04740	1.37757169
32	RNA polymerase_Homo sapiens_hsa03020	1.33594269
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.30443936
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.27320717
35	Antigen processing and presentation_Homo sapiens_hsa04612	1.23232918
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.19891967
37	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.15465511
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14578095
39	Phototransduction_Homo sapiens_hsa04744	1.13537251
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.12021593
41	Purine metabolism_Homo sapiens_hsa00230	1.06471103
42	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.01902582
43	Regulation of autophagy_Homo sapiens_hsa04140	1.00494878
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97265957
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93249962
46	ABC transporters_Homo sapiens_hsa02010	0.91603388
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.89119507
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83663910
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80057864
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78372365
51	Circadian entrainment_Homo sapiens_hsa04713	0.77664976
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77178409
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.76258924
54	Chemokine signaling pathway_Homo sapiens_hsa04062	0.73734373
55	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73358308
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.73130260
57	Lysine degradation_Homo sapiens_hsa00310	0.72155507
58	Fatty acid degradation_Homo sapiens_hsa00071	0.71954063
59	Serotonergic synapse_Homo sapiens_hsa04726	0.70056448
60	Salivary secretion_Homo sapiens_hsa04970	0.67876166
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67786312
62	Retinol metabolism_Homo sapiens_hsa00830	0.67425638
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66510010
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.66267135
65	Cholinergic synapse_Homo sapiens_hsa04725	0.64004512
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63591639
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62461244
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59061183
69	Propanoate metabolism_Homo sapiens_hsa00640	0.55597704
70	Insulin secretion_Homo sapiens_hsa04911	0.54848211
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53665809
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53530891
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.53347705
74	Cocaine addiction_Homo sapiens_hsa05030	0.52765534
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.52690290
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52239833
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.51971371
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51766052
79	Basal transcription factors_Homo sapiens_hsa03022	0.50106538
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44437784
81	Base excision repair_Homo sapiens_hsa03410	0.44391570
82	Homologous recombination_Homo sapiens_hsa03440	0.43113412
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42241843
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40876799
85	MAPK signaling pathway_Homo sapiens_hsa04010	0.40847922
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40737278
87	RNA degradation_Homo sapiens_hsa03018	0.40130460
88	Caffeine metabolism_Homo sapiens_hsa00232	0.39962848
89	Sulfur relay system_Homo sapiens_hsa04122	0.39494770
90	Herpes simplex infection_Homo sapiens_hsa05168	0.35751145
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.34748699
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34503202
93	Gastric acid secretion_Homo sapiens_hsa04971	0.33541161
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32282143
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.29752789
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26560697
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24719160
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23695597
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.21995983
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.20403998

HMGB1P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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