HMGB1P19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA integration (GO:0015074)5.84029892
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.77239976
3tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.77239976
4negative regulation of neurotransmitter secretion (GO:0046929)5.44298045
5translesion synthesis (GO:0019985)4.93379562
6sulfate transmembrane transport (GO:1902358)4.67199096
7sulfate transport (GO:0008272)4.64501303
8polyol transport (GO:0015791)4.48328726
9positive regulation of mitotic sister chromatid separation (GO:1901970)4.47689257
10positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.47689257
11positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.47689257
12retinal cone cell development (GO:0046549)4.43772428
13pyrimidine dimer repair (GO:0006290)4.40061543
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.35442973
15signal peptide processing (GO:0006465)4.35241580
16attachment of spindle microtubules to kinetochore (GO:0008608)4.33027012
17microtubule anchoring (GO:0034453)4.30656965
18single strand break repair (GO:0000012)4.26571361
19auditory receptor cell stereocilium organization (GO:0060088)4.26524373
20replication fork processing (GO:0031297)4.20906611
21negative regulation of neurotransmitter transport (GO:0051589)3.96657247
22meiotic chromosome segregation (GO:0045132)3.96285636
23rRNA methylation (GO:0031167)3.91881484
24postreplication repair (GO:0006301)3.85785826
25DNA double-strand break processing (GO:0000729)3.83538111
26metaphase plate congression (GO:0051310)3.82045427
27transepithelial transport (GO:0070633)3.74315469
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.61558513
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.60302419
30detection of light stimulus involved in visual perception (GO:0050908)3.56663174
31detection of light stimulus involved in sensory perception (GO:0050962)3.56663174
32positive regulation of mitochondrial fission (GO:0090141)3.54903920
33regulation of translational fidelity (GO:0006450)3.54140513
34protein polyglutamylation (GO:0018095)3.50295493
35negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.43898530
36kinetochore assembly (GO:0051382)3.42211211
37histone H3-K9 methylation (GO:0051567)3.39140898
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.35819916
39iron-sulfur cluster assembly (GO:0016226)3.30161454
40metallo-sulfur cluster assembly (GO:0031163)3.30161454
41histone H3-K4 trimethylation (GO:0080182)3.28913795
42protein K11-linked deubiquitination (GO:0035871)3.28615629
43DNA damage response, detection of DNA damage (GO:0042769)3.27284963
44rRNA modification (GO:0000154)3.25421734
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23451081
46regulation of hippo signaling (GO:0035330)3.21203113
47positive regulation of chromosome segregation (GO:0051984)3.19023341
48centriole replication (GO:0007099)3.17258504
49cellular zinc ion homeostasis (GO:0006882)3.16424119
50kinetochore organization (GO:0051383)3.16302104
51hematopoietic stem cell proliferation (GO:0071425)3.15620924
52regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.11266557
53nucleotide-excision repair, DNA damage removal (GO:0000718)3.02695788
54DNA excision (GO:0044349)3.02695788
55inner ear receptor stereocilium organization (GO:0060122)3.02599250
56photoreceptor cell maintenance (GO:0045494)3.00593048
57mitotic metaphase plate congression (GO:0007080)2.99058859
58amino acid salvage (GO:0043102)2.97681033
59L-methionine salvage (GO:0071267)2.97681033
60L-methionine biosynthetic process (GO:0071265)2.97681033
61mitotic chromosome condensation (GO:0007076)2.96408642
62establishment of protein localization to Golgi (GO:0072600)2.96347748
63DNA deamination (GO:0045006)2.95121496
64negative regulation of JUN kinase activity (GO:0043508)2.93987085
65phasic smooth muscle contraction (GO:0014821)2.89736274
66positive regulation of DNA-templated transcription, initiation (GO:2000144)2.83911918
67intestinal absorption (GO:0050892)2.83151711
68establishment of chromosome localization (GO:0051303)2.83129817
69sperm capacitation (GO:0048240)2.81813521
70protein targeting to Golgi (GO:0000042)2.81339712
71photoreceptor cell development (GO:0042461)2.79514652
72recombinational repair (GO:0000725)2.79384735
73DNA methylation involved in gamete generation (GO:0043046)2.78284036
74oxidative demethylation (GO:0070989)2.78127978
75regulation of mRNA splicing, via spliceosome (GO:0048024)2.76898098
76behavioral response to nicotine (GO:0035095)2.76783796
77cullin deneddylation (GO:0010388)2.75359732
78histone H3-K9 modification (GO:0061647)2.71146131
79regulation of T cell receptor signaling pathway (GO:0050856)2.71094967
80histone H2A monoubiquitination (GO:0035518)2.68384423
81cilium morphogenesis (GO:0060271)2.68116500
82double-strand break repair (GO:0006302)2.67816170
83telomere maintenance via semi-conservative replication (GO:0032201)2.66748304
84peptidyl-lysine methylation (GO:0018022)2.66070835
85peptidyl-lysine trimethylation (GO:0018023)2.65941800
86chromatin remodeling at centromere (GO:0031055)2.65430184
87DNA demethylation (GO:0080111)2.64810287
88zinc ion homeostasis (GO:0055069)2.63814221
89double-strand break repair via homologous recombination (GO:0000724)2.63664956
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63290018
91negative regulation of cell killing (GO:0031342)2.63290018
92positive regulation of cytokinesis (GO:0032467)2.63087886
93retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62222908
94eye photoreceptor cell development (GO:0042462)2.59426617
95nuclear pore organization (GO:0006999)2.59124208
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58315467
97telomere maintenance via recombination (GO:0000722)2.57716012
98positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.56600681
99mRNA cleavage (GO:0006379)2.53709564
100mitotic recombination (GO:0006312)2.53066810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.91978347
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21586529
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.53084612
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.37962618
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31291114
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26524150
7ELK1_19687146_ChIP-ChIP_HELA_Human3.12636826
8IGF1R_20145208_ChIP-Seq_DFB_Human2.97653671
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.89194857
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.79134265
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77233304
12TAF15_26573619_Chip-Seq_HEK293_Human2.68917410
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.52423261
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48908203
15ZNF274_21170338_ChIP-Seq_K562_Hela2.46161259
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35913110
17EWS_26573619_Chip-Seq_HEK293_Human2.29185626
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16145410
19VDR_23849224_ChIP-Seq_CD4+_Human2.14137841
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10599625
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01520830
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95423086
23MYC_18940864_ChIP-ChIP_HL60_Human1.92069996
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89661123
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89355745
26FOXP3_21729870_ChIP-Seq_TREG_Human1.89259635
27VDR_22108803_ChIP-Seq_LS180_Human1.83754216
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.81177628
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77063388
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72195033
31IRF1_19129219_ChIP-ChIP_H3396_Human1.68578057
32DCP1A_22483619_ChIP-Seq_HELA_Human1.53194503
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51483826
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.49085024
35E2F7_22180533_ChIP-Seq_HELA_Human1.48778795
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48546180
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46483388
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45908683
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39444318
40P300_19829295_ChIP-Seq_ESCs_Human1.37591377
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.37024480
42FUS_26573619_Chip-Seq_HEK293_Human1.35010019
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34469006
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34167084
45GABP_19822575_ChIP-Seq_HepG2_Human1.33853910
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32519161
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31364196
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.27658799
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23330830
50CBP_20019798_ChIP-Seq_JUKART_Human1.22822098
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22822098
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22357198
53BCAT_22108803_ChIP-Seq_LS180_Human1.20112918
54GATA3_26560356_Chip-Seq_TH2_Human1.18640602
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17046824
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16613960
57ER_23166858_ChIP-Seq_MCF-7_Human1.14578209
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13343104
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12049680
60KDM5A_27292631_Chip-Seq_BREAST_Human1.11242962
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11145160
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10426250
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10077929
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08346184
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07423247
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06687869
67CIITA_25753668_ChIP-Seq_RAJI_Human1.05984738
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.04257960
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03544750
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03029362
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02217585
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01535481
73P300_18555785_Chip-Seq_ESCs_Mouse0.99703050
74GATA3_26560356_Chip-Seq_TH1_Human0.99527577
75FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97441077
76P53_22387025_ChIP-Seq_ESCs_Mouse0.97028670
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96793222
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95859278
79E2F1_21310950_ChIP-Seq_MCF-7_Human0.94673664
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94488790
81E2F1_18555785_Chip-Seq_ESCs_Mouse0.93137914
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.91173775
83TAL1_26923725_Chip-Seq_HPCs_Mouse0.89053854
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88636870
85NMYC_18555785_Chip-Seq_ESCs_Mouse0.88197149
86ETV1_20927104_ChIP-Seq_GIST48_Human0.87981543
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87796397
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87618615
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87618615
90CDX2_22108803_ChIP-Seq_LS180_Human0.87128651
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.87028028
92SOX2_18555785_Chip-Seq_ESCs_Mouse0.87020529
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87011199
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.86404725
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85604683
96GBX2_23144817_ChIP-Seq_PC3_Human0.85579472
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.85421528
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85350775
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84994283
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.84416260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.29567440
2MP0008877_abnormal_DNA_methylation3.96748816
3MP0003787_abnormal_imprinting3.19629002
4MP0008058_abnormal_DNA_repair2.92182136
5MP0002009_preneoplasia2.59920888
6MP0010094_abnormal_chromosome_stability2.55962831
7MP0004145_abnormal_muscle_electrophysio2.55722152
8MP0002653_abnormal_ependyma_morphology2.45282628
9MP0004957_abnormal_blastocyst_morpholog2.45026727
10MP0005083_abnormal_biliary_tract2.36760151
11MP0003252_abnormal_bile_duct2.33159234
12MP0002837_dystrophic_cardiac_calcinosis1.94107794
13MP0003693_abnormal_embryo_hatching1.93622594
14MP0003646_muscle_fatigue1.80536988
15MP0004264_abnormal_extraembryonic_tissu1.80332658
16MP0008875_abnormal_xenobiotic_pharmacok1.80101349
17MP0003718_maternal_effect1.77997541
18MP0002102_abnormal_ear_morphology1.71577786
19MP0008932_abnormal_embryonic_tissue1.70649035
20MP0001293_anophthalmia1.60305886
21MP0003315_abnormal_perineum_morphology1.59294262
22MP0000569_abnormal_digit_pigmentation1.57618221
23MP0008789_abnormal_olfactory_epithelium1.51756506
24MP0003111_abnormal_nucleus_morphology1.49578809
25MP0000538_abnormal_urinary_bladder1.48239254
26MP0001502_abnormal_circadian_rhythm1.46122711
27MP0001919_abnormal_reproductive_system1.45959279
28MP0002163_abnormal_gland_morphology1.43121806
29MP0005551_abnormal_eye_electrophysiolog1.42362834
30MP0003878_abnormal_ear_physiology1.40566737
31MP0005377_hearing/vestibular/ear_phenot1.40566737
32MP0003123_paternal_imprinting1.35944402
33MP0001485_abnormal_pinna_reflex1.35426694
34MP0004036_abnormal_muscle_relaxation1.29297366
35MP0001188_hyperpigmentation1.26339206
36MP0005367_renal/urinary_system_phenotyp1.26311915
37MP0000516_abnormal_urinary_system1.26311915
38MP0003195_calcinosis1.24296755
39MP0001661_extended_life_span1.23724884
40MP0004142_abnormal_muscle_tone1.21337723
41MP0002132_abnormal_respiratory_system1.20192031
42MP0001929_abnormal_gametogenesis1.18866969
43MP0005646_abnormal_pituitary_gland1.16406176
44MP0004147_increased_porphyrin_level1.15392274
45MP0003077_abnormal_cell_cycle1.13978922
46MP0002210_abnormal_sex_determination1.13829439
47MP0008872_abnormal_physiological_respon1.12401242
48MP0002166_altered_tumor_susceptibility1.09364665
49MP0005671_abnormal_response_to1.08318859
50MP0004233_abnormal_muscle_weight1.07050997
51MP0001270_distended_abdomen1.04720052
52MP0006036_abnormal_mitochondrial_physio1.02245190
53MP0003786_premature_aging1.01188987
54MP0005085_abnormal_gallbladder_physiolo1.01083481
55MP0005084_abnormal_gallbladder_morpholo0.99233859
56MP0005075_abnormal_melanosome_morpholog0.98409173
57MP0003567_abnormal_fetal_cardiomyocyte0.97766483
58MP0000372_irregular_coat_pigmentation0.95954952
59MP0002638_abnormal_pupillary_reflex0.93848325
60MP0008995_early_reproductive_senescence0.92823137
61MP0001145_abnormal_male_reproductive0.90335534
62MP0009053_abnormal_anal_canal0.89853489
63MP0003136_yellow_coat_color0.88618946
64MP0008007_abnormal_cellular_replicative0.87866581
65MP0002557_abnormal_social/conspecific_i0.87576730
66MP0005499_abnormal_olfactory_system0.87134233
67MP0005394_taste/olfaction_phenotype0.87134233
68MP0002006_tumorigenesis0.86607385
69MP0003698_abnormal_male_reproductive0.84398396
70MP0003890_abnormal_embryonic-extraembry0.84229587
71MP0000653_abnormal_sex_gland0.83453351
72MP0006276_abnormal_autonomic_nervous0.82926836
73MP0006292_abnormal_olfactory_placode0.81591175
74MP0002138_abnormal_hepatobiliary_system0.80636030
75MP0000647_abnormal_sebaceous_gland0.79764151
76MP0009765_abnormal_xenobiotic_induced0.77421620
77MP0001191_abnormal_skin_condition0.75393731
78MP0002234_abnormal_pharynx_morphology0.75035234
79MP0004215_abnormal_myocardial_fiber0.74372795
80MP0002254_reproductive_system_inflammat0.73677939
81MP0008873_increased_physiological_sensi0.72223744
82MP0005410_abnormal_fertilization0.72142100
83MP0003115_abnormal_respiratory_system0.71867441
84MP0000358_abnormal_cell_content/0.71348726
85MP0003950_abnormal_plasma_membrane0.69967684
86MP0003186_abnormal_redox_activity0.68998902
87MP0000778_abnormal_nervous_system0.68968242
88MP0005195_abnormal_posterior_eye0.68815963
89MP0001440_abnormal_grooming_behavior0.67693563
90MP0005253_abnormal_eye_physiology0.66246644
91MP0003755_abnormal_palate_morphology0.66064031
92MP0002736_abnormal_nociception_after0.65221854
93MP0005379_endocrine/exocrine_gland_phen0.65153969
94MP0005645_abnormal_hypothalamus_physiol0.65057185
95MP0000470_abnormal_stomach_morphology0.65047475
96MP0001119_abnormal_female_reproductive0.63884289
97MP0000703_abnormal_thymus_morphology0.63119152
98MP0004043_abnormal_pH_regulation0.63095160
99MP0009764_decreased_sensitivity_to0.63030206
100MP0002233_abnormal_nose_morphology0.62743242

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)5.49082291
2Renal cortical cysts (HP:0000803)4.19520224
3Abnormal spermatogenesis (HP:0008669)4.10661408
4Abnormality of midbrain morphology (HP:0002418)3.99197016
5Molar tooth sign on MRI (HP:0002419)3.99197016
6Pancreatic cysts (HP:0001737)3.86568959
7Hypoplasia of the capital femoral epiphysis (HP:0003090)3.82755367
8Abnormality of the renal cortex (HP:0011035)3.77636020
9Abnormality of DNA repair (HP:0003254)3.72562392
10Pancreatic fibrosis (HP:0100732)3.67669600
11Prostate neoplasm (HP:0100787)3.33309834
12Absent epiphyses (HP:0010577)3.17871719
13Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.17871719
14Ependymoma (HP:0002888)3.16931957
15Prominent metopic ridge (HP:0005487)3.04755858
16Sclerocornea (HP:0000647)2.92867389
17Chromsome breakage (HP:0040012)2.92588432
18Gonadotropin excess (HP:0000837)2.90649530
19Abnormality of the metopic suture (HP:0005556)2.87766653
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.85698042
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81305151
22Flat capital femoral epiphysis (HP:0003370)2.79953931
23Enlarged kidneys (HP:0000105)2.78693993
24Calf muscle hypertrophy (HP:0008981)2.77001486
25Carpal bone hypoplasia (HP:0001498)2.76725096
26True hermaphroditism (HP:0010459)2.75905212
27Poor eye contact (HP:0000817)2.75841565
28Irregular epiphyses (HP:0010582)2.71508010
29Astrocytoma (HP:0009592)2.67361009
30Abnormality of the astrocytes (HP:0100707)2.67361009
31Disproportionate short-trunk short stature (HP:0003521)2.65936324
32Hypothermia (HP:0002045)2.60021712
33Asplenia (HP:0001746)2.57875385
34Cystic liver disease (HP:0006706)2.54082939
35Nephronophthisis (HP:0000090)2.52174955
36Posterior subcapsular cataract (HP:0007787)2.49800520
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.47878757
38Bile duct proliferation (HP:0001408)2.44692969
39Abnormal biliary tract physiology (HP:0012439)2.44692969
40Testicular atrophy (HP:0000029)2.40161905
41Muscle hypertrophy of the lower extremities (HP:0008968)2.37295463
42Abnormality of the renal medulla (HP:0100957)2.36582004
43Glioma (HP:0009733)2.34549797
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.33526141
45Lissencephaly (HP:0001339)2.29628934
46Congenital stationary night blindness (HP:0007642)2.27126364
47Hepatocellular necrosis (HP:0001404)2.25712296
48Tubular atrophy (HP:0000092)2.25281445
49Sloping forehead (HP:0000340)2.22818256
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.20625698
51Squamous cell carcinoma (HP:0002860)2.18714707
52Abnormality of chromosome stability (HP:0003220)2.17804803
53Abnormality of the preputium (HP:0100587)2.16213455
54Abnormal drinking behavior (HP:0030082)2.15021008
55Polydipsia (HP:0001959)2.15021008
56Oculomotor apraxia (HP:0000657)2.14901532
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13142064
58Patellar aplasia (HP:0006443)2.11613870
59Supernumerary spleens (HP:0009799)2.10444213
60Abnormality of the pons (HP:0007361)2.08235387
61Long palpebral fissure (HP:0000637)2.07461302
62Medial flaring of the eyebrow (HP:0010747)2.07270632
63Abnormality of the prostate (HP:0008775)2.04949509
64Hepatic necrosis (HP:0002605)2.03113212
65Type II lissencephaly (HP:0007260)2.03068091
66Delayed myelination (HP:0012448)2.02983969
67Diastasis recti (HP:0001540)2.01866189
68Meckel diverticulum (HP:0002245)2.00515359
69Gaze-evoked nystagmus (HP:0000640)1.99699390
70Abolished electroretinogram (ERG) (HP:0000550)1.97879337
71Preaxial hand polydactyly (HP:0001177)1.96378153
72Highly arched eyebrow (HP:0002553)1.95413935
73Tented upper lip vermilion (HP:0010804)1.94979459
74Abnormality of the labia minora (HP:0012880)1.92485542
75Abnormality of the ileum (HP:0001549)1.91635630
76Occipital encephalocele (HP:0002085)1.89554402
77Aplasia/Hypoplasia of the patella (HP:0006498)1.88766832
78Abnormality of secondary sexual hair (HP:0009888)1.87161056
79Abnormality of the axillary hair (HP:0100134)1.87161056
80Chronic diarrhea (HP:0002028)1.85860457
81Male pseudohermaphroditism (HP:0000037)1.85538535
82Entropion (HP:0000621)1.84836864
83Birth length less than 3rd percentile (HP:0003561)1.82218070
84Amyotrophic lateral sclerosis (HP:0007354)1.79909785
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.78198355
86Gait imbalance (HP:0002141)1.78059980
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77587948
88Postaxial foot polydactyly (HP:0001830)1.77491722
89Anencephaly (HP:0002323)1.77258507
90Bilateral microphthalmos (HP:0007633)1.76410184
91Hypoproteinemia (HP:0003075)1.74651456
92Impaired social interactions (HP:0000735)1.74589906
93Abnormal social behavior (HP:0012433)1.74589906
94Attenuation of retinal blood vessels (HP:0007843)1.74379731
95Narrow forehead (HP:0000341)1.74204637
96Broad distal phalanx of finger (HP:0009836)1.72321951
97Duodenal stenosis (HP:0100867)1.72264980
98Small intestinal stenosis (HP:0012848)1.72264980
99Abnormality of B cell number (HP:0010975)1.72107527
100Female pseudohermaphroditism (HP:0010458)1.71820218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK24.57054476
2TRIM284.12523259
3ZAK3.03777375
4BRSK22.83258251
5MST42.71391664
6BCR2.71277236
7FRK2.46213883
8MAPK132.40263256
9BRSK12.21425378
10NEK12.06538648
11SIK32.00130313
12BMPR1B1.95998262
13MAP3K41.95229569
14IRAK21.88789252
15BMPR21.83231496
16MARK31.78899965
17STK161.78892486
18TTK1.65451415
19WEE11.54891076
20ERBB31.54480459
21PAK61.49163957
22TSSK61.48973558
23PLK41.48408761
24TXK1.47738299
25BUB11.38684541
26STK31.33893314
27NME11.32286842
28MKNK21.27325562
29EIF2AK21.22615959
30NEK21.17649137
31NUAK11.17412459
32TLK11.16348723
33TNIK1.14586810
34PDK21.14130810
35CCNB11.13777652
36NTRK31.08039429
37CDK81.02399955
38VRK11.02113784
39FER0.98303702
40CDC70.93836137
41NEK90.90158749
42CDK190.89827333
43EIF2AK30.87368896
44IKBKB0.87224792
45STK40.84553881
46BCKDK0.84248398
47MAP2K70.82934140
48GRK10.81231701
49CHEK10.80364682
50DYRK20.80009989
51IKBKE0.79381696
52RPS6KA40.78392801
53TGFBR10.77013111
54PLK30.73630839
55MKNK10.73551690
56PAK30.73375772
57DYRK1A0.73344744
58NTRK20.72351057
59CDK90.71932900
60DYRK1B0.71608431
61ATM0.70858290
62EPHA40.70599518
63PLK10.70172895
64ATR0.65865649
65TEC0.65309191
66MAPKAPK30.64251075
67DAPK20.63572453
68AKT30.63526588
69ABL20.62210659
70MAP3K100.61849880
71AURKB0.60088825
72SRPK10.59931526
73CDK30.58719204
74PRKCQ0.54782463
75VRK20.54230380
76AURKA0.53768840
77ADRBK20.52910192
78CAMKK20.52811329
79CAMK10.50951958
80PRKCZ0.50332210
81PLK20.49206867
82BTK0.48658949
83IRAK10.47150780
84EIF2AK10.46142466
85OXSR10.45619286
86PRKD30.45195891
87MAPK110.44750036
88JAK10.44272206
89CHEK20.44088946
90CLK10.44034053
91EPHB20.42827340
92CDK70.41489500
93ITK0.39893990
94PKN10.39874505
95PTK2B0.39643362
96CDK10.38776637
97BRD40.37813110
98KSR10.37729664
99NEK60.36637210
100CAMK2G0.36213925

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.66460998
2Homologous recombination_Homo sapiens_hsa034403.66347668
3Mismatch repair_Homo sapiens_hsa034303.38075773
4Fanconi anemia pathway_Homo sapiens_hsa034603.06798163
5Non-homologous end-joining_Homo sapiens_hsa034502.79124771
6Nucleotide excision repair_Homo sapiens_hsa034202.67984887
7Base excision repair_Homo sapiens_hsa034102.61132428
8Lysine degradation_Homo sapiens_hsa003102.44366857
9Protein export_Homo sapiens_hsa030602.36349380
10Butanoate metabolism_Homo sapiens_hsa006502.11518896
11DNA replication_Homo sapiens_hsa030302.09658511
12Tryptophan metabolism_Homo sapiens_hsa003802.04688105
13Propanoate metabolism_Homo sapiens_hsa006402.00592920
14RNA polymerase_Homo sapiens_hsa030201.99264607
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93167872
16Mineral absorption_Homo sapiens_hsa049781.92941938
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88774056
18Nitrogen metabolism_Homo sapiens_hsa009101.87607207
19Basal transcription factors_Homo sapiens_hsa030221.87119634
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.81152765
21Proteasome_Homo sapiens_hsa030501.78923940
22Phototransduction_Homo sapiens_hsa047441.70293772
23Regulation of autophagy_Homo sapiens_hsa041401.67159446
24RNA transport_Homo sapiens_hsa030131.66299288
25Olfactory transduction_Homo sapiens_hsa047401.57579556
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52597983
27Peroxisome_Homo sapiens_hsa041461.45780050
28RNA degradation_Homo sapiens_hsa030181.43989382
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42095375
30Steroid biosynthesis_Homo sapiens_hsa001001.29078139
31Sulfur metabolism_Homo sapiens_hsa009201.28129066
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27476313
33mRNA surveillance pathway_Homo sapiens_hsa030151.24681689
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21107513
35Spliceosome_Homo sapiens_hsa030401.21036025
36Fatty acid metabolism_Homo sapiens_hsa012121.20286755
37One carbon pool by folate_Homo sapiens_hsa006701.13985926
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11350394
39Oxidative phosphorylation_Homo sapiens_hsa001901.08323708
40Pyruvate metabolism_Homo sapiens_hsa006201.07610774
41Primary immunodeficiency_Homo sapiens_hsa053401.04255136
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01052372
43Linoleic acid metabolism_Homo sapiens_hsa005910.96806114
44Fatty acid elongation_Homo sapiens_hsa000620.96198666
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.94074515
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92575438
47Fatty acid degradation_Homo sapiens_hsa000710.91917208
48Parkinsons disease_Homo sapiens_hsa050120.90179057
49Cell cycle_Homo sapiens_hsa041100.89724005
50Caffeine metabolism_Homo sapiens_hsa002320.88653540
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.87266207
52Retinol metabolism_Homo sapiens_hsa008300.82945770
53Pyrimidine metabolism_Homo sapiens_hsa002400.82635570
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79956146
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78503156
56Taste transduction_Homo sapiens_hsa047420.78248986
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76500351
58Folate biosynthesis_Homo sapiens_hsa007900.74751985
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70779685
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70225166
61Oocyte meiosis_Homo sapiens_hsa041140.65413245
62Glycerolipid metabolism_Homo sapiens_hsa005610.65159687
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64538399
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64452489
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61743602
66Huntingtons disease_Homo sapiens_hsa050160.60942929
67Ether lipid metabolism_Homo sapiens_hsa005650.53947626
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53179521
69Purine metabolism_Homo sapiens_hsa002300.51477987
70Chemical carcinogenesis_Homo sapiens_hsa052040.50016614
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49301534
72Glutathione metabolism_Homo sapiens_hsa004800.48834810
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47681875
74beta-Alanine metabolism_Homo sapiens_hsa004100.47501934
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43775723
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43424341
77ABC transporters_Homo sapiens_hsa020100.42798066
78Sphingolipid metabolism_Homo sapiens_hsa006000.41272097
79Histidine metabolism_Homo sapiens_hsa003400.41092138
80p53 signaling pathway_Homo sapiens_hsa041150.40937244
81Alzheimers disease_Homo sapiens_hsa050100.39752439
82Antigen processing and presentation_Homo sapiens_hsa046120.39388487
83Fat digestion and absorption_Homo sapiens_hsa049750.37104495
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.36529066
85Metabolic pathways_Homo sapiens_hsa011000.36391838
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36183192
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34301416
88T cell receptor signaling pathway_Homo sapiens_hsa046600.32929336
89Nicotine addiction_Homo sapiens_hsa050330.32858592
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29656462
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29182521
92Ribosome_Homo sapiens_hsa030100.28582792
93Circadian rhythm_Homo sapiens_hsa047100.28577052
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26112674
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25335257
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24193322
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23971470
98Arginine biosynthesis_Homo sapiens_hsa002200.22835199
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21172487
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.20519253

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