HMGB1P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.40646645
2chaperone-mediated protein transport (GO:0072321)4.86023811
3ATP synthesis coupled proton transport (GO:0015986)4.76421790
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.76421790
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75598420
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.65143575
7DNA deamination (GO:0045006)4.58886013
8protein complex biogenesis (GO:0070271)4.29224970
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27206457
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.27206457
11NADH dehydrogenase complex assembly (GO:0010257)4.27206457
12GTP biosynthetic process (GO:0006183)4.08392668
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.08000871
14mitochondrial respiratory chain complex assembly (GO:0033108)4.00616036
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97595583
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.92576425
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.90124618
18maturation of SSU-rRNA (GO:0030490)3.85705231
19chromatin remodeling at centromere (GO:0031055)3.82070294
20respiratory electron transport chain (GO:0022904)3.67692241
21electron transport chain (GO:0022900)3.66971907
22DNA replication checkpoint (GO:0000076)3.63422311
23CENP-A containing nucleosome assembly (GO:0034080)3.58328199
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58247315
25water-soluble vitamin biosynthetic process (GO:0042364)3.56968835
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48692784
27ribosomal small subunit assembly (GO:0000028)3.46092515
28pyrimidine nucleotide catabolic process (GO:0006244)3.44985785
29UTP biosynthetic process (GO:0006228)3.44649503
30kinetochore organization (GO:0051383)3.41875830
31kinetochore assembly (GO:0051382)3.38559143
32regulation of cellular amino acid metabolic process (GO:0006521)3.36601731
33UTP metabolic process (GO:0046051)3.28698571
34pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.25144136
35cytidine catabolic process (GO:0006216)3.23718167
36cytidine deamination (GO:0009972)3.23718167
37cytidine metabolic process (GO:0046087)3.23718167
38telomere maintenance via semi-conservative replication (GO:0032201)3.22873193
39pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21103317
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18923047
41DNA strand elongation involved in DNA replication (GO:0006271)3.17891965
42CTP metabolic process (GO:0046036)3.17063705
43CTP biosynthetic process (GO:0006241)3.17063705
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.16009372
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14821295
46negative regulation of ligase activity (GO:0051352)3.14821295
47deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.13415982
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11009150
49negative regulation of thymocyte apoptotic process (GO:0070244)3.10771588
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.07130180
51termination of RNA polymerase III transcription (GO:0006386)3.07130180
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06281438
53resolution of meiotic recombination intermediates (GO:0000712)3.04407973
54deoxyribose phosphate catabolic process (GO:0046386)3.03850254
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03150337
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03150337
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03150337
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01869636
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01869636
60DNA double-strand break processing (GO:0000729)3.00206404
61DNA strand elongation (GO:0022616)2.99335818
62deoxyribonucleotide catabolic process (GO:0009264)2.96723095
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96547495
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96547495
65histone exchange (GO:0043486)2.96547116
66viral transcription (GO:0019083)2.95729632
67inner mitochondrial membrane organization (GO:0007007)2.95681002
68mitotic recombination (GO:0006312)2.95174335
69DNA ligation (GO:0006266)2.93465471
70purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93098841
71rRNA modification (GO:0000154)2.92834547
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91397641
73cytochrome complex assembly (GO:0017004)2.90513303
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.90193936
75respiratory chain complex IV assembly (GO:0008535)2.89777950
76translational termination (GO:0006415)2.88017493
77signal transduction involved in DNA damage checkpoint (GO:0072422)2.87802341
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87802341
79telomere maintenance via recombination (GO:0000722)2.87181900
80cellular component biogenesis (GO:0044085)2.87044054
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86184825
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.85973132
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.85587161
84negative regulation of DNA-dependent DNA replication (GO:2000104)2.85100735
85negative regulation of telomere maintenance (GO:0032205)2.82210195
86DNA damage response, detection of DNA damage (GO:0042769)2.81325671
87ribosomal large subunit biogenesis (GO:0042273)2.79946916
88guanosine-containing compound biosynthetic process (GO:1901070)2.79536953
89base-excision repair, AP site formation (GO:0006285)2.79053301
90replication fork processing (GO:0031297)2.78293212
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77338465
92pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.76100806
93pyrimidine ribonucleoside catabolic process (GO:0046133)2.75432860
94cotranslational protein targeting to membrane (GO:0006613)2.75177649
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73034864
96behavioral response to nicotine (GO:0035095)2.72859368
97protein targeting to ER (GO:0045047)2.72230205
98translation (GO:0006412)2.70601841
99DNA replication-independent nucleosome organization (GO:0034724)2.69503675
100DNA replication-independent nucleosome assembly (GO:0006336)2.69503675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.63674824
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63585138
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.42059668
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.89988899
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.83179040
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75833744
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21736221
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02256488
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98257955
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.83490098
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77517466
12EZH2_22144423_ChIP-Seq_EOC_Human2.73996663
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.60595320
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53674081
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.46529827
16VDR_23849224_ChIP-Seq_CD4+_Human2.44138475
17ELK1_19687146_ChIP-ChIP_HELA_Human2.43000789
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25318111
19FOXP3_21729870_ChIP-Seq_TREG_Human2.23987677
20MYC_18940864_ChIP-ChIP_HL60_Human2.09795319
21ZNF274_21170338_ChIP-Seq_K562_Hela1.96794892
22VDR_22108803_ChIP-Seq_LS180_Human1.91342064
23EWS_26573619_Chip-Seq_HEK293_Human1.88833173
24IRF1_19129219_ChIP-ChIP_H3396_Human1.83845185
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80240494
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79023369
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73129033
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72858478
29IGF1R_20145208_ChIP-Seq_DFB_Human1.71363891
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.66430761
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.66389748
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63311073
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52117110
34TTF2_22483619_ChIP-Seq_HELA_Human1.51387559
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49539050
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49460951
37GABP_19822575_ChIP-Seq_HepG2_Human1.49353423
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.49255155
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46207688
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40031753
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34617141
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34367341
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33792695
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32043213
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32031468
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30253851
47FUS_26573619_Chip-Seq_HEK293_Human1.30111353
48P300_19829295_ChIP-Seq_ESCs_Human1.27434761
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.24044111
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22263948
51TP53_22573176_ChIP-Seq_HFKS_Human1.21155274
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20860524
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16965527
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13212346
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11364133
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09958427
57NCOR_22424771_ChIP-Seq_293T_Human1.09206057
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09016645
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08346074
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08224679
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07927472
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.05870608
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.05779270
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05779270
65DCP1A_22483619_ChIP-Seq_HELA_Human1.05144088
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.03647881
67CIITA_25753668_ChIP-Seq_RAJI_Human1.02418655
68CBP_20019798_ChIP-Seq_JUKART_Human1.01972267
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01972267
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01161699
71THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99264967
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97775958
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97410249
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96306251
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93501653
76ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93093797
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93010724
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91438905
79TAF2_19829295_ChIP-Seq_ESCs_Human0.89772466
80SOX2_19829295_ChIP-Seq_ESCs_Human0.89231225
81NANOG_19829295_ChIP-Seq_ESCs_Human0.89231225
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88165427
83NANOG_20526341_ChIP-Seq_ESCs_Human0.87254557
84XRN2_22483619_ChIP-Seq_HELA_Human0.86915778
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86911782
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86696085
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85120388
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83670534
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83479083
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83389838
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83369240
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.83256606
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82882363
94AR_20517297_ChIP-Seq_VCAP_Human0.81906271
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81862683
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.80909689
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80364492
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79108601
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78802932
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78100131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.30542519
2MP0008877_abnormal_DNA_methylation4.00803842
3MP0010094_abnormal_chromosome_stability3.15642753
4MP0004147_increased_porphyrin_level3.07360560
5MP0003787_abnormal_imprinting2.72110220
6MP0005084_abnormal_gallbladder_morpholo2.64735667
7MP0003693_abnormal_embryo_hatching2.42196353
8MP0009379_abnormal_foot_pigmentation2.36875988
9MP0006072_abnormal_retinal_apoptosis2.19511263
10MP0002102_abnormal_ear_morphology2.13838439
11MP0008058_abnormal_DNA_repair2.13090439
12MP0002736_abnormal_nociception_after1.97193701
13MP0000372_irregular_coat_pigmentation1.93260440
14MP0008875_abnormal_xenobiotic_pharmacok1.92920590
15MP0003121_genomic_imprinting1.89278982
16MP0001905_abnormal_dopamine_level1.86883078
17MP0005671_abnormal_response_to1.86811387
18MP0003122_maternal_imprinting1.82064615
19MP0002234_abnormal_pharynx_morphology1.77771217
20MP0008872_abnormal_physiological_respon1.72464600
21MP0005551_abnormal_eye_electrophysiolog1.70679533
22MP0002166_altered_tumor_susceptibility1.69532579
23MP0008789_abnormal_olfactory_epithelium1.69493256
24MP0002006_tumorigenesis1.67262235
25MP0001293_anophthalmia1.63898402
26MP0001968_abnormal_touch/_nociception1.58682108
27MP0005646_abnormal_pituitary_gland1.57050561
28MP0005075_abnormal_melanosome_morpholog1.56486364
29MP0004142_abnormal_muscle_tone1.50544819
30MP0004957_abnormal_blastocyst_morpholog1.44198939
31MP0006036_abnormal_mitochondrial_physio1.42292842
32MP0005389_reproductive_system_phenotype1.39283695
33MP0002876_abnormal_thyroid_physiology1.36681451
34MP0002160_abnormal_reproductive_system1.36142249
35MP0001986_abnormal_taste_sensitivity1.33976645
36MP0005253_abnormal_eye_physiology1.33613039
37MP0005499_abnormal_olfactory_system1.32756918
38MP0005394_taste/olfaction_phenotype1.32756918
39MP0003890_abnormal_embryonic-extraembry1.31770862
40MP0003111_abnormal_nucleus_morphology1.31600180
41MP0004885_abnormal_endolymph1.29583775
42MP0002837_dystrophic_cardiac_calcinosis1.27825587
43MP0002095_abnormal_skin_pigmentation1.27440868
44MP0006276_abnormal_autonomic_nervous1.23141875
45MP0001919_abnormal_reproductive_system1.23078885
46MP0008007_abnormal_cellular_replicative1.20662722
47MP0003186_abnormal_redox_activity1.19503791
48MP0002272_abnormal_nervous_system1.15042902
49MP0002138_abnormal_hepatobiliary_system1.14246057
50MP0003011_delayed_dark_adaptation1.12630474
51MP0003718_maternal_effect1.12348775
52MP0009745_abnormal_behavioral_response1.08487221
53MP0002735_abnormal_chemical_nociception1.06073586
54MP0001486_abnormal_startle_reflex1.05273063
55MP0004742_abnormal_vestibular_system1.02032511
56MP0002653_abnormal_ependyma_morphology1.01450761
57MP0008932_abnormal_embryonic_tissue1.01337099
58MP0001485_abnormal_pinna_reflex1.00617841
59MP0005410_abnormal_fertilization1.00420549
60MP0002163_abnormal_gland_morphology1.00345605
61MP0003786_premature_aging1.00222040
62MP0004043_abnormal_pH_regulation0.99428369
63MP0001835_abnormal_antigen_presentation0.98252353
64MP0001529_abnormal_vocalization0.97824709
65MP0004133_heterotaxia0.97264664
66MP0003252_abnormal_bile_duct0.96706397
67MP0002210_abnormal_sex_determination0.96000571
68MP0000427_abnormal_hair_cycle0.94247525
69MP0006035_abnormal_mitochondrial_morpho0.94116644
70MP0002009_preneoplasia0.93980255
71MP0003646_muscle_fatigue0.93949869
72MP0005195_abnormal_posterior_eye0.93336804
73MP0001929_abnormal_gametogenesis0.91415125
74MP0002938_white_spotting0.91108263
75MP0002148_abnormal_hypersensitivity_rea0.90638959
76MP0001727_abnormal_embryo_implantation0.90103416
77MP0002638_abnormal_pupillary_reflex0.88778362
78MP0004145_abnormal_muscle_electrophysio0.85667295
79MP0002752_abnormal_somatic_nervous0.84114961
80MP0002557_abnormal_social/conspecific_i0.81938507
81MP0009697_abnormal_copulation0.81218537
82MP0003195_calcinosis0.79691166
83MP0004215_abnormal_myocardial_fiber0.78811118
84MP0001963_abnormal_hearing_physiology0.77524455
85MP0001440_abnormal_grooming_behavior0.77415509
86MP0001800_abnormal_humoral_immune0.77363932
87MP0003077_abnormal_cell_cycle0.75177962
88MP0002184_abnormal_innervation0.72925506
89MP0000653_abnormal_sex_gland0.71187923
90MP0003806_abnormal_nucleotide_metabolis0.70082264
91MP0002733_abnormal_thermal_nociception0.69423144
92MP0001145_abnormal_male_reproductive0.69196516
93MP0003315_abnormal_perineum_morphology0.69042142
94MP0001970_abnormal_pain_threshold0.68773503
95MP0005083_abnormal_biliary_tract0.67926332
96MP0003879_abnormal_hair_cell0.67580901
97MP0000049_abnormal_middle_ear0.65600158
98MP0001119_abnormal_female_reproductive0.64936483
99MP0000613_abnormal_salivary_gland0.64417145
100MP0003698_abnormal_male_reproductive0.64163655

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.38275669
2Abnormal mitochondria in muscle tissue (HP:0008316)4.07435887
3Acute encephalopathy (HP:0006846)3.84165728
4Mitochondrial inheritance (HP:0001427)3.81247378
5Progressive macrocephaly (HP:0004481)3.60705572
6Increased CSF lactate (HP:0002490)3.57049166
7B lymphocytopenia (HP:0010976)3.54078950
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.47261347
9Severe combined immunodeficiency (HP:0004430)3.42204516
10Hepatocellular necrosis (HP:0001404)3.34186930
11Abnormality of B cell number (HP:0010975)3.31679434
12Hypoproteinemia (HP:0003075)3.31344260
13Panhypogammaglobulinemia (HP:0003139)3.09532064
14Hepatic necrosis (HP:0002605)3.07365163
15Increased hepatocellular lipid droplets (HP:0006565)3.03990938
16Colon cancer (HP:0003003)3.03548428
17Pancreatic fibrosis (HP:0100732)3.02666036
18Thyroiditis (HP:0100646)3.01454521
19Reticulocytopenia (HP:0001896)2.99560804
20Cerebral edema (HP:0002181)2.89137076
21Molar tooth sign on MRI (HP:0002419)2.86819420
22Abnormality of midbrain morphology (HP:0002418)2.86819420
23Methylmalonic acidemia (HP:0002912)2.83852414
24Pancreatic cysts (HP:0001737)2.83408115
25Combined immunodeficiency (HP:0005387)2.79274358
26Lipid accumulation in hepatocytes (HP:0006561)2.73482029
27Absent/shortened dynein arms (HP:0200106)2.71405375
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.71405375
29Abnormality of cells of the erythroid lineage (HP:0012130)2.70523830
30Decreased central vision (HP:0007663)2.70130588
31Pendular nystagmus (HP:0012043)2.69629334
32Abnormal rod and cone electroretinograms (HP:0008323)2.67005584
33Absent thumb (HP:0009777)2.64425788
34Increased serum lactate (HP:0002151)2.61077324
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59977521
36Increased intramyocellular lipid droplets (HP:0012240)2.55036755
37IgG deficiency (HP:0004315)2.49770218
38Hyperglycinemia (HP:0002154)2.49250127
39Hypoplasia of the thymus (HP:0000778)2.46469698
40Lactic acidosis (HP:0003128)2.45269407
41Abnormality of the pons (HP:0007361)2.43161754
42Optic disc pallor (HP:0000543)2.42711433
43True hermaphroditism (HP:0010459)2.39966157
44Hypoplasia of the pons (HP:0012110)2.39680002
45Abnormality of DNA repair (HP:0003254)2.35530177
46Abnormal number of erythroid precursors (HP:0012131)2.33670825
47Abnormality of the ileum (HP:0001549)2.32646349
48Chromsome breakage (HP:0040012)2.32557653
49Renal Fanconi syndrome (HP:0001994)2.31723112
50Nephronophthisis (HP:0000090)2.31120137
51Abolished electroretinogram (ERG) (HP:0000550)2.29330167
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29303078
53Meckel diverticulum (HP:0002245)2.28992527
54Congenital stationary night blindness (HP:0007642)2.27084112
55Birth length less than 3rd percentile (HP:0003561)2.25259477
56Methylmalonic aciduria (HP:0012120)2.23622255
57Leukodystrophy (HP:0002415)2.22521855
58Abnormality of the labia minora (HP:0012880)2.17221232
59Microvesicular hepatic steatosis (HP:0001414)2.16095606
603-Methylglutaconic aciduria (HP:0003535)2.14864102
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.14353412
62Abnormal ciliary motility (HP:0012262)2.12971297
63Congenital, generalized hypertrichosis (HP:0004540)2.12445770
64Attenuation of retinal blood vessels (HP:0007843)2.11707506
65Asplenia (HP:0001746)2.07731157
66Pancytopenia (HP:0001876)2.05364120
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.04362881
68Respiratory failure (HP:0002878)2.03853168
69Volvulus (HP:0002580)2.03205642
70Abnormal respiratory motile cilium morphology (HP:0005938)2.03129722
71Abnormal respiratory epithelium morphology (HP:0012253)2.03129722
72Abnormal respiratory motile cilium physiology (HP:0012261)2.01040137
73Macrocytic anemia (HP:0001972)1.98489761
74Increased muscle lipid content (HP:0009058)1.97394678
75Supernumerary spleens (HP:0009799)1.96523822
76Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94932078
77Dicarboxylic aciduria (HP:0003215)1.94932078
78Exercise intolerance (HP:0003546)1.94657993
79Abnormality of alanine metabolism (HP:0010916)1.93823554
80Hyperalaninemia (HP:0003348)1.93823554
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93823554
82Abnormality of the renal collecting system (HP:0004742)1.93546993
83Agammaglobulinemia (HP:0004432)1.93500435
84Lethargy (HP:0001254)1.92861440
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89680260
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89680260
87Type II lissencephaly (HP:0007260)1.87753505
88Intestinal atresia (HP:0011100)1.87655892
89Renal cortical cysts (HP:0000803)1.84491575
90T lymphocytopenia (HP:0005403)1.84126017
91Sclerocornea (HP:0000647)1.83247684
92Erythroderma (HP:0001019)1.81349089
93Medial flaring of the eyebrow (HP:0010747)1.80046362
94Abnormality of the renal medulla (HP:0100957)1.79754589
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79745264
96Duplicated collecting system (HP:0000081)1.79209527
97Respiratory difficulties (HP:0002880)1.78236489
98Abnormality of eosinophils (HP:0001879)1.77331666
99Thyroid-stimulating hormone excess (HP:0002925)1.76482168
100Abnormality of the prostate (HP:0008775)1.75916517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.48005101
2STK163.31756643
3ZAK3.15110495
4CDC72.85470972
5NUAK12.71869430
6MAP4K22.68992009
7EIF2AK32.40800785
8BUB12.04360294
9TLK11.98272766
10NME11.97015163
11KDR1.94094663
12NEK11.91886962
13BMPR1B1.91882954
14PLK41.91467847
15FRK1.86369437
16VRK11.82400222
17WNK41.76603159
18PLK31.74056168
19OXSR11.66515138
20TAOK31.64124994
21CDK191.59872701
22DYRK21.58903302
23TAF11.56192761
24PLK21.51433545
25BCKDK1.45102627
26ADRBK21.43690423
27WNK31.43123876
28MAPK131.42539096
29GRK11.40419686
30TIE11.38897601
31STK391.34996829
32CSNK1G31.23405189
33CSNK1G21.21216865
34TESK21.20716933
35CDK81.19425905
36MAPKAPK51.18670745
37DAPK11.16540845
38ATR1.15711192
39TSSK61.14368163
40PLK11.08837505
41MAPKAPK31.08069868
42BCR1.05074907
43MKNK21.02238526
44EIF2AK20.97742708
45CSNK1G10.94399550
46PINK10.92968650
47KIT0.87143510
48CAMKK20.84322742
49WEE10.82485311
50CSNK1A1L0.81818814
51MST40.81423690
52LIMK10.81402662
53MKNK10.80271543
54CHEK20.79662879
55SRPK10.79163008
56NEK20.78015850
57GRK50.75367236
58INSRR0.73727192
59FES0.72842713
60PBK0.72447276
61TEC0.71217833
62TNIK0.70663810
63MINK10.69197146
64TTK0.68363669
65CDK140.68264005
66AURKB0.67122824
67PRKCG0.64955861
68RPS6KA50.64196994
69DAPK20.62183733
70CSNK2A20.59549854
71PRKCI0.58526490
72TXK0.58077916
73PRKCQ0.55070100
74CSNK2A10.54864778
75AURKA0.54333336
76ATM0.52051266
77EPHB20.50709806
78MAP2K70.49414541
79CCNB10.48027799
80CSNK1E0.47699721
81CDK150.45870836
82TRIM280.45177897
83CDK180.44922993
84CDK11A0.43898864
85WNK10.41227135
86SYK0.41180612
87EIF2AK10.40530460
88PIK3CG0.39801854
89CSNK1A10.39144087
90PHKG10.37857741
91PHKG20.37857741
92PRKACA0.36307858
93PIM20.35695176
94DAPK30.35580492
95ABL20.35410649
96CDK30.35341352
97ILK0.35306300
98PIM10.35177263
99PDK20.34965946
100MAP3K40.33476267

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28129230
2Oxidative phosphorylation_Homo sapiens_hsa001903.56526506
3DNA replication_Homo sapiens_hsa030303.43269046
4Ribosome_Homo sapiens_hsa030103.30432983
5Parkinsons disease_Homo sapiens_hsa050123.17801213
6Mismatch repair_Homo sapiens_hsa034303.07356010
7Protein export_Homo sapiens_hsa030602.67344328
8Homologous recombination_Homo sapiens_hsa034402.56126951
9RNA polymerase_Homo sapiens_hsa030202.51305767
10Huntingtons disease_Homo sapiens_hsa050162.16745098
11Non-homologous end-joining_Homo sapiens_hsa034502.07836191
12Base excision repair_Homo sapiens_hsa034102.07399513
13Nucleotide excision repair_Homo sapiens_hsa034202.06533206
14Alzheimers disease_Homo sapiens_hsa050102.04396771
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04116439
16Fanconi anemia pathway_Homo sapiens_hsa034601.96340581
17RNA degradation_Homo sapiens_hsa030181.87495366
18Primary immunodeficiency_Homo sapiens_hsa053401.82865221
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82309246
20Asthma_Homo sapiens_hsa053101.78799881
21Spliceosome_Homo sapiens_hsa030401.76403929
22Cardiac muscle contraction_Homo sapiens_hsa042601.71846649
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71553801
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70915317
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65611931
26Pyrimidine metabolism_Homo sapiens_hsa002401.57546829
27One carbon pool by folate_Homo sapiens_hsa006701.56821791
28Propanoate metabolism_Homo sapiens_hsa006401.44996035
29Phototransduction_Homo sapiens_hsa047441.43399543
30Basal transcription factors_Homo sapiens_hsa030221.35234683
31RNA transport_Homo sapiens_hsa030131.35136277
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.31643868
33Purine metabolism_Homo sapiens_hsa002301.30734446
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24339878
35Autoimmune thyroid disease_Homo sapiens_hsa053201.20969512
36Allograft rejection_Homo sapiens_hsa053301.18203609
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16655839
38Peroxisome_Homo sapiens_hsa041461.08715300
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03566029
40Fatty acid elongation_Homo sapiens_hsa000620.99114727
41Butanoate metabolism_Homo sapiens_hsa006500.98683528
42Antigen processing and presentation_Homo sapiens_hsa046120.94714256
43Sulfur relay system_Homo sapiens_hsa041220.93471275
44Caffeine metabolism_Homo sapiens_hsa002320.90277333
45Graft-versus-host disease_Homo sapiens_hsa053320.90032245
46Glutathione metabolism_Homo sapiens_hsa004800.87018935
47Type I diabetes mellitus_Homo sapiens_hsa049400.85558781
48Tryptophan metabolism_Homo sapiens_hsa003800.85540260
49Linoleic acid metabolism_Homo sapiens_hsa005910.84750711
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81800310
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.79908956
52Cell cycle_Homo sapiens_hsa041100.78146903
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75210468
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74483701
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72713447
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71286051
57Folate biosynthesis_Homo sapiens_hsa007900.70919569
58Pyruvate metabolism_Homo sapiens_hsa006200.69592027
59beta-Alanine metabolism_Homo sapiens_hsa004100.67604115
60Fatty acid degradation_Homo sapiens_hsa000710.63415327
61Metabolic pathways_Homo sapiens_hsa011000.62823376
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61742320
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61514753
64Olfactory transduction_Homo sapiens_hsa047400.57530075
65Nicotine addiction_Homo sapiens_hsa050330.56992684
66Arachidonic acid metabolism_Homo sapiens_hsa005900.56598699
67Chemical carcinogenesis_Homo sapiens_hsa052040.56391671
68p53 signaling pathway_Homo sapiens_hsa041150.56139275
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55117280
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53991774
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48539160
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48042679
73Hematopoietic cell lineage_Homo sapiens_hsa046400.46327428
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46011160
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44880304
76Ether lipid metabolism_Homo sapiens_hsa005650.43002657
77Nitrogen metabolism_Homo sapiens_hsa009100.42965074
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41595769
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41545456
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39530788
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37365721
82Fatty acid metabolism_Homo sapiens_hsa012120.36570333
83Epstein-Barr virus infection_Homo sapiens_hsa051690.35796531
84Rheumatoid arthritis_Homo sapiens_hsa053230.34713188
85Oocyte meiosis_Homo sapiens_hsa041140.32113467
86Taste transduction_Homo sapiens_hsa047420.31095144
87Systemic lupus erythematosus_Homo sapiens_hsa053220.29592847
88Retinol metabolism_Homo sapiens_hsa008300.28371570
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28100792
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27382260
91Fat digestion and absorption_Homo sapiens_hsa049750.26436711
92Morphine addiction_Homo sapiens_hsa050320.25447559
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.22118343
94Selenocompound metabolism_Homo sapiens_hsa004500.21202433
95mRNA surveillance pathway_Homo sapiens_hsa030150.20987847
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.20822783
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.18829059
98Carbon metabolism_Homo sapiens_hsa012000.17983895
99Salivary secretion_Homo sapiens_hsa049700.17376004
100N-Glycan biosynthesis_Homo sapiens_hsa005100.17283589

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