ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	5.86451355
2	regulation of meiosis I (GO:0060631)	5.02474762
3	adaptation of signaling pathway (GO:0023058)	4.87592115
4	tongue development (GO:0043586)	4.46225374
5	embryonic camera-type eye development (GO:0031076)	4.37549347
6	platelet dense granule organization (GO:0060155)	4.15958997
7	replication fork processing (GO:0031297)	4.08377298
8	proteasome assembly (GO:0043248)	4.06378839
9	kinetochore assembly (GO:0051382)	4.04553403
10	DNA strand renaturation (GO:0000733)	3.92454665
11	synaptic transmission, cholinergic (GO:0007271)	3.67782601
12	regulation of sarcomere organization (GO:0060297)	3.61339398
13	resolution of meiotic recombination intermediates (GO:0000712)	3.55164568
14	kinetochore organization (GO:0051383)	3.52059904
15	positive regulation of protein depolymerization (GO:1901881)	3.46211280
16	chaperone-mediated protein transport (GO:0072321)	3.41510813
17	negative regulation of meiosis (GO:0045835)	3.30966481
18	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.30618435
19	positive regulation of chemokine secretion (GO:0090197)	3.26678042
20	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.24424316
21	chromatin remodeling at centromere (GO:0031055)	3.22120981
22	cartilage morphogenesis (GO:0060536)	3.17553556
23	prenylation (GO:0097354)	3.14931218
24	protein prenylation (GO:0018342)	3.14931218
25	cullin deneddylation (GO:0010388)	3.14524614
26	positive regulation of macrophage activation (GO:0043032)	3.13920861
27	male meiosis I (GO:0007141)	3.13363648
28	negative regulation of macrophage differentiation (GO:0045650)	3.09383794
29	CENP-A containing nucleosome assembly (GO:0034080)	3.08882529
30	response to pheromone (GO:0019236)	3.06201204
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.02654817
32	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.94475927
33	regulation of mitotic spindle checkpoint (GO:1903504)	2.94475927
34	positive regulation of meiosis (GO:0045836)	2.92725441
35	neuron fate determination (GO:0048664)	2.82963579
36	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.82854173
37	attachment of spindle microtubules to kinetochore (GO:0008608)	2.82738278
38	recombinational repair (GO:0000725)	2.82649229
39	intraciliary transport (GO:0042073)	2.81776774
40	protein localization to kinetochore (GO:0034501)	2.81766128
41	histone exchange (GO:0043486)	2.81447842
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.81319602
43	double-strand break repair via homologous recombination (GO:0000724)	2.80881859
44	anterograde synaptic vesicle transport (GO:0048490)	2.80414139
45	DNA integration (GO:0015074)	2.79378075
46	regulation of DNA endoreduplication (GO:0032875)	2.78273647
47	amine catabolic process (GO:0009310)	2.76196245
48	cellular biogenic amine catabolic process (GO:0042402)	2.76196245
49	regulation of cilium movement (GO:0003352)	2.73058007
50	behavioral response to nicotine (GO:0035095)	2.71420105
51	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.71347894
52	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.71347894
53	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.71347894
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71089837
55	protein complex biogenesis (GO:0070271)	2.70527245
56	protein deneddylation (GO:0000338)	2.70288618
57	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.69767177
58	eosinophil chemotaxis (GO:0048245)	2.69757097
59	mitotic metaphase plate congression (GO:0007080)	2.68935329
60	positive regulation of meiotic cell cycle (GO:0051446)	2.68462950
61	metaphase plate congression (GO:0051310)	2.67218061
62	respiratory chain complex IV assembly (GO:0008535)	2.65913014
63	regulation of cellular respiration (GO:0043457)	2.65600843
64	regulation of gonadotropin secretion (GO:0032276)	2.65058847
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.63109397
66	rRNA modification (GO:0000154)	2.62113639
67	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.61030734
68	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.59277987
69	multicellular organism reproduction (GO:0032504)	2.58595074
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58469556
71	microtubule anchoring (GO:0034453)	2.57882572
72	rRNA methylation (GO:0031167)	2.57703567
73	positive regulation of protein complex disassembly (GO:0043243)	2.56986107
74	regulation of chemokine secretion (GO:0090196)	2.55434617
75	negative regulation of mast cell activation (GO:0033004)	2.55254551
76	regulation of gene silencing by miRNA (GO:0060964)	2.54891769
77	regulation of gene silencing by RNA (GO:0060966)	2.54891769
78	regulation of posttranscriptional gene silencing (GO:0060147)	2.54891769
79	reciprocal DNA recombination (GO:0035825)	2.54654226
80	reciprocal meiotic recombination (GO:0007131)	2.54654226
81	ovulation cycle (GO:0042698)	2.53613140
82	protein localization to cilium (GO:0061512)	2.53585542
83	vascular smooth muscle contraction (GO:0014829)	2.53411196
84	DNA-dependent DNA replication (GO:0006261)	2.53197187
85	cytochrome complex assembly (GO:0017004)	2.51855032
86	piRNA metabolic process (GO:0034587)	2.51414059
87	epithelial cilium movement (GO:0003351)	2.50096578
88	water-soluble vitamin biosynthetic process (GO:0042364)	2.48787856
89	meiosis I (GO:0007127)	2.47477517
90	telomere maintenance via telomerase (GO:0007004)	2.46717376
91	peptidyl-histidine modification (GO:0018202)	2.45069845
92	protein localization to chromosome, centromeric region (GO:0071459)	2.45048038
93	kidney morphogenesis (GO:0060993)	2.44166429
94	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.42469213
95	NADH dehydrogenase complex assembly (GO:0010257)	2.42469213
96	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.42469213
97	transmission of nerve impulse (GO:0019226)	2.41929771
98	behavioral response to ethanol (GO:0048149)	2.41804003
99	anterior/posterior axis specification, embryo (GO:0008595)	2.41413499
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.38581664

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.09624572
2	VDR_22108803_ChIP-Seq_LS180_Human	3.08703056
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.83400769
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.79611258
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78473543
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.77472756
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.71746848
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.53237474
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.49327537
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35530778
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30710563
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11213206
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08630108
14	FUS_26573619_Chip-Seq_HEK293_Human	2.08163725
15	P300_19829295_ChIP-Seq_ESCs_Human	2.07019080
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02541612
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02243071
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01637617
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.95922919
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93087081
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92785746
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91024468
23	EWS_26573619_Chip-Seq_HEK293_Human	1.88677818
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86585747
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.81025683
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.80988571
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72894529
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.72873645
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.66813627
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60677243
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55596309
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49128432
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48383939
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45806842
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44043988
36	TCF4_22108803_ChIP-Seq_LS180_Human	1.43069464
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42572314
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.41164897
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40754512
40	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.40051547
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39982876
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38263516
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38201423
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35359334
45	STAT3_23295773_ChIP-Seq_U87_Human	1.35063184
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35052790
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.34631582
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32459797
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31225351
50	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.29830668
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29736272
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28710645
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27804921
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27781725
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.27064824
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27064824
57	CJUN_26792858_Chip-Seq_BT549_Human	1.26362872
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26324933
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.25129228
60	GATA1_22025678_ChIP-Seq_K562_Human	1.24952989
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.24578727
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23525564
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23525564
64	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.22656036
65	AR_25329375_ChIP-Seq_VCAP_Human	1.21114256
66	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.20005814
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19146021
68	BRD4_25478319_ChIP-Seq_HGPS_Human	1.18852725
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18171732
70	TCF4_23295773_ChIP-Seq_U87_Human	1.17584751
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15992835
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15992835
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15486882
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14945582
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13442553
76	JUN_21703547_ChIP-Seq_K562_Human	1.12585782
77	CDX2_22108803_ChIP-Seq_LS180_Human	1.12322455
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11012373
79	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.10789035
80	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.10789035
81	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.10789035
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09753471
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.08627320
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08333196
85	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.08331210
86	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07568462
87	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07167315
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06932716
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06867377
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.06256555
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06137012
92	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05940827
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04997448
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03558961
95	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.02695988
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01629447
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01506109
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00752205
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00000402
100	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.99851466

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	5.46628563
2	MP0003136_yellow_coat_color	4.10513672
3	MP0002254_reproductive_system_inflammat	4.09331740
4	MP0006292_abnormal_olfactory_placode	3.83879709
5	MP0000372_irregular_coat_pigmentation	3.81453081
6	MP0005171_absent_coat_pigmentation	3.40115536
7	MP0005174_abnormal_tail_pigmentation	3.20602052
8	MP0008877_abnormal_DNA_methylation	2.97074179
9	MP0002234_abnormal_pharynx_morphology	2.64303201
10	MP0009379_abnormal_foot_pigmentation	2.57663721
11	MP0005670_abnormal_white_adipose	2.56385913
12	MP0003890_abnormal_embryonic-extraembry	2.27557816
13	MP0001293_anophthalmia	2.10226724
14	MP0002876_abnormal_thyroid_physiology	2.03931910
15	MP0000569_abnormal_digit_pigmentation	2.01281911
16	MP0000749_muscle_degeneration	1.96965155
17	MP0008058_abnormal_DNA_repair	1.96319960
18	MP0005551_abnormal_eye_electrophysiolog	1.91617987
19	MP0005187_abnormal_penis_morphology	1.86186220
20	MP0010030_abnormal_orbit_morphology	1.77827026
21	MP0002233_abnormal_nose_morphology	1.77790290
22	MP0008789_abnormal_olfactory_epithelium	1.76386131
23	MP0003755_abnormal_palate_morphology	1.73688750
24	MP0003195_calcinosis	1.73209095
25	MP0001299_abnormal_eye_distance/	1.66775160
26	MP0000427_abnormal_hair_cycle	1.61002584
27	MP0002295_abnormal_pulmonary_circulatio	1.55235565
28	MP0008872_abnormal_physiological_respon	1.54359461
29	MP0004145_abnormal_muscle_electrophysio	1.48907572
30	MP0002736_abnormal_nociception_after	1.46326002
31	MP0004133_heterotaxia	1.44339558
32	MP0002938_white_spotting	1.41906797
33	MP0000015_abnormal_ear_pigmentation	1.40226605
34	MP0001324_abnormal_eye_pigmentation	1.38511303
35	MP0004215_abnormal_myocardial_fiber	1.37530383
36	MP0002282_abnormal_trachea_morphology	1.36815279
37	MP0003718_maternal_effect	1.35729023
38	MP0003011_delayed_dark_adaptation	1.33310676
39	MP0003646_muscle_fatigue	1.29819879
40	MP0005408_hypopigmentation	1.24552302
41	MP0001346_abnormal_lacrimal_gland	1.19961913
42	MP0001485_abnormal_pinna_reflex	1.15861161
43	MP0002102_abnormal_ear_morphology	1.14834662
44	MP0003315_abnormal_perineum_morphology	1.12128868
45	MP0000613_abnormal_salivary_gland	1.11447567
46	MP0000647_abnormal_sebaceous_gland	1.11052024
47	MP0002095_abnormal_skin_pigmentation	1.10798573
48	MP0010094_abnormal_chromosome_stability	1.10700735
49	MP0005253_abnormal_eye_physiology	1.09212168
50	MP0001968_abnormal_touch/_nociception	1.07093632
51	MP0003186_abnormal_redox_activity	1.07029659
52	MP0003936_abnormal_reproductive_system	1.06069353
53	MP0003879_abnormal_hair_cell	1.00825840
54	MP0008775_abnormal_heart_ventricle	0.99835383
55	MP0003937_abnormal_limbs/digits/tail_de	0.98072598
56	MP0004233_abnormal_muscle_weight	0.97665275
57	MP0001986_abnormal_taste_sensitivity	0.95235252
58	MP0005275_abnormal_skin_tensile	0.94012420
59	MP0008438_abnormal_cutaneous_collagen	0.93243325
60	MP0005197_abnormal_uvea_morphology	0.92757468
61	MP0000762_abnormal_tongue_morphology	0.92690892
62	MP0002837_dystrophic_cardiac_calcinosis	0.91851804
63	MP0001119_abnormal_female_reproductive	0.91609988
64	MP0005195_abnormal_posterior_eye	0.91076974
65	MP0005394_taste/olfaction_phenotype	0.89541680
66	MP0005499_abnormal_olfactory_system	0.89541680
67	MP0010368_abnormal_lymphatic_system	0.87718600
68	MP0002210_abnormal_sex_determination	0.84680203
69	MP0002163_abnormal_gland_morphology	0.84330201
70	MP0005391_vision/eye_phenotype	0.83328257
71	MP0003935_abnormal_craniofacial_develop	0.83016734
72	MP0006072_abnormal_retinal_apoptosis	0.81604905
73	MP0005503_abnormal_tendon_morphology	0.81084831
74	MP0001286_abnormal_eye_development	0.80845481
75	MP0009250_abnormal_appendicular_skeleto	0.80804664
76	MP0002751_abnormal_autonomic_nervous	0.79154863
77	MP0002184_abnormal_innervation	0.73465489
78	MP0005377_hearing/vestibular/ear_phenot	0.73333320
79	MP0003878_abnormal_ear_physiology	0.73333320
80	MP0001929_abnormal_gametogenesis	0.71183612
81	MP0002638_abnormal_pupillary_reflex	0.70327404
82	MP0003693_abnormal_embryo_hatching	0.70247320
83	MP0005395_other_phenotype	0.67326952
84	MP0005084_abnormal_gallbladder_morpholo	0.67203409
85	MP0000653_abnormal_sex_gland	0.66883617
86	MP0000163_abnormal_cartilage_morphology	0.66295261
87	MP0004084_abnormal_cardiac_muscle	0.65293641
88	MP0000631_abnormal_neuroendocrine_gland	0.64554187
89	MP0003787_abnormal_imprinting	0.64153701
90	MP0000432_abnormal_head_morphology	0.62193824
91	MP0006036_abnormal_mitochondrial_physio	0.61857636
92	MP0006054_spinal_hemorrhage	0.61438772
93	MP0000383_abnormal_hair_follicle	0.61435137
94	MP0002090_abnormal_vision	0.61357674
95	MP0004019_abnormal_vitamin_homeostasis	0.60798202
96	MP0003786_premature_aging	0.60716869
97	MP0004264_abnormal_extraembryonic_tissu	0.59359937
98	MP0002752_abnormal_somatic_nervous	0.58786053
99	MP0003942_abnormal_urinary_system	0.58665502
100	MP0000026_abnormal_inner_ear	0.57594016

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Asplenia (HP:0001746)	3.71232592
2	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.58697256
3	Molar tooth sign on MRI (HP:0002419)	3.36051290
4	Abnormality of midbrain morphology (HP:0002418)	3.36051290
5	Pancreatic cysts (HP:0001737)	2.94007204
6	Hypomagnesemia (HP:0002917)	2.89940195
7	Facial cleft (HP:0002006)	2.88461319
8	Abnormal lung lobation (HP:0002101)	2.74855091
9	Chronic hepatic failure (HP:0100626)	2.74390542
10	Bifid tongue (HP:0010297)	2.73043365
11	Pancreatic fibrosis (HP:0100732)	2.70561828
12	Polydipsia (HP:0001959)	2.68055185
13	Abnormal drinking behavior (HP:0030082)	2.68055185
14	Septo-optic dysplasia (HP:0100842)	2.67008623
15	Follicular hyperkeratosis (HP:0007502)	2.66309273
16	Intestinal atresia (HP:0011100)	2.57601546
17	Tubular atrophy (HP:0000092)	2.56873414
18	Abnormality of magnesium homeostasis (HP:0004921)	2.50450028
19	Retinal atrophy (HP:0001105)	2.47705362
20	Bilateral sensorineural hearing impairment (HP:0008619)	2.46346594
21	True hermaphroditism (HP:0010459)	2.40703339
22	Acute necrotizing encephalopathy (HP:0006965)	2.38574397
23	Supernumerary spleens (HP:0009799)	2.35380628
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.34285840
25	Nephronophthisis (HP:0000090)	2.32487398
26	Abnormality of dental color (HP:0011073)	2.32163956
27	Abdominal situs inversus (HP:0003363)	2.30322346
28	Abnormality of abdominal situs (HP:0011620)	2.30322346
29	Abnormality of the renal medulla (HP:0100957)	2.29367803
30	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28303427
31	Abnormality of chromosome stability (HP:0003220)	2.27527571
32	Oligodactyly (hands) (HP:0001180)	2.26486444
33	Abnormality of the fovea (HP:0000493)	2.25480951
34	Decreased muscle mass (HP:0003199)	2.24879018
35	Amelogenesis imperfecta (HP:0000705)	2.24778157
36	Meckel diverticulum (HP:0002245)	2.23798010
37	Hypokalemic alkalosis (HP:0001949)	2.23676810
38	Anencephaly (HP:0002323)	2.22104580
39	Colon cancer (HP:0003003)	2.20429033
40	Increased circulating renin level (HP:0000848)	2.19622309
41	Patent foramen ovale (HP:0001655)	2.15649539
42	Abnormality of the ileum (HP:0001549)	2.15255130
43	Abnormality of the pons (HP:0007361)	2.14592288
44	Polyuria (HP:0000103)	2.13963286
45	Progressive macrocephaly (HP:0004481)	2.13581710
46	Sloping forehead (HP:0000340)	2.13332260
47	Rhabdomyosarcoma (HP:0002859)	2.12354734
48	Optic disc pallor (HP:0000543)	2.12023494
49	Anophthalmia (HP:0000528)	2.09346219
50	Tetany (HP:0001281)	2.09069247
51	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.08994380
52	Hypoplasia of the fovea (HP:0007750)	2.08994380
53	Bilateral microphthalmos (HP:0007633)	2.07009298
54	Chromsome breakage (HP:0040012)	2.06369162
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06063632
56	Type II lissencephaly (HP:0007260)	2.03688396
57	Acute encephalopathy (HP:0006846)	2.02498005
58	Postaxial foot polydactyly (HP:0001830)	2.00952134
59	Volvulus (HP:0002580)	1.99312485
60	Increased CSF lactate (HP:0002490)	1.96766485
61	Congenital sensorineural hearing impairment (HP:0008527)	1.94623913
62	Ectopic kidney (HP:0000086)	1.94174622
63	Optic nerve hypoplasia (HP:0000609)	1.93501485
64	Enlarged kidneys (HP:0000105)	1.91890791
65	Median cleft lip (HP:0000161)	1.91804395
66	Abnormality of the renal cortex (HP:0011035)	1.91315630
67	Abnormal ciliary motility (HP:0012262)	1.87414878
68	Small intestinal stenosis (HP:0012848)	1.87149543
69	Duodenal stenosis (HP:0100867)	1.87149543
70	Microretrognathia (HP:0000308)	1.85609647
71	Rectal fistula (HP:0100590)	1.85576301
72	Rectovaginal fistula (HP:0000143)	1.85576301
73	Absent septum pellucidum (HP:0001331)	1.84571503
74	Abnormal mitochondria in muscle tissue (HP:0008316)	1.84478559
75	Dandy-Walker malformation (HP:0001305)	1.83197709
76	Fair hair (HP:0002286)	1.83124462
77	Type 2 muscle fiber atrophy (HP:0003554)	1.81685822
78	Abnormality of the duodenum (HP:0002246)	1.80959544
79	Alopecia of scalp (HP:0002293)	1.80936972
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80167185
81	Type I transferrin isoform profile (HP:0003642)	1.77543004
82	Congenital hepatic fibrosis (HP:0002612)	1.76781229
83	Generalized myoclonic seizures (HP:0002123)	1.75160379
84	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.73837093
85	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.73094222
86	Absent thumb (HP:0009777)	1.72721897
87	Occipital encephalocele (HP:0002085)	1.70709964
88	Absent eyebrow (HP:0002223)	1.68290664
89	Disproportionate short-trunk short stature (HP:0003521)	1.68195672
90	Constricted visual fields (HP:0001133)	1.67948466
91	Keratoconus (HP:0000563)	1.67611773
92	Increased corneal curvature (HP:0100692)	1.67611773
93	Abnormal urine output (HP:0012590)	1.67263664
94	Mitochondrial inheritance (HP:0001427)	1.67204412
95	Astigmatism (HP:0000483)	1.65658570
96	Triphalangeal thumb (HP:0001199)	1.64075498
97	Sensory axonal neuropathy (HP:0003390)	1.63939129
98	Abnormal protein glycosylation (HP:0012346)	1.63443656
99	Abnormal glycosylation (HP:0012345)	1.63443656
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.63443656

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK39	4.79608727
2	WNK4	4.29760119
3	OXSR1	3.73533814
4	FRK	3.33228054
5	TNIK	3.24046601
6	ACVR1B	2.83162994
7	PDK2	2.55627083
8	BMPR1B	2.49503472
9	NUAK1	2.41677036
10	STK16	2.07375550
11	PLK2	2.00328876
12	PBK	1.96900888
13	MUSK	1.88336055
14	BUB1	1.80011702
15	ZAK	1.73769900
16	VRK2	1.61003204
17	MKNK2	1.57293055
18	WNK1	1.47042758
19	PNCK	1.46511722
20	MARK3	1.45260542
21	ADRBK2	1.39972504
22	PLK4	1.39238788
23	WEE1	1.37933343
24	GRK1	1.37643887
25	PLK3	1.35380168
26	LATS1	1.27846639
27	TRIM28	1.27691521
28	PINK1	1.26328597
29	STK3	1.20314128
30	NEK1	1.18727745
31	STK38L	1.18527385
32	INSRR	1.15224800
33	TTK	1.13935419
34	EIF2AK3	1.07750350
35	WNK3	1.06181050
36	MAP4K2	1.05349138
37	MST4	1.03861207
38	CLK1	1.02658065
39	BRSK2	1.02185015
40	DMPK	0.98219568
41	MAP3K4	0.95754492
42	TAF1	0.94702478
43	PLK1	0.93463522
44	MKNK1	0.92099939
45	OBSCN	0.88671608
46	NEK6	0.86619845
47	PAK3	0.86493549
48	PRKCI	0.84664183
49	CDC7	0.84271583
50	CCNB1	0.82167080
51	TGFBR2	0.81165903
52	CASK	0.80434219
53	ADRBK1	0.79715427
54	MAP2K7	0.76594507
55	MAPK13	0.75817782
56	EPHB2	0.71320251
57	EIF2AK1	0.70142533
58	PRKCE	0.69068132
59	CSNK1G2	0.68318984
60	TLK1	0.67389556
61	MAP3K12	0.67099527
62	AKT3	0.66326829
63	BCR	0.64388249
64	VRK1	0.63269873
65	CHEK2	0.58411705
66	MINK1	0.57491662
67	NME1	0.57438487
68	BRSK1	0.57154329
69	TSSK6	0.57086585
70	FGFR1	0.56755480
71	DYRK2	0.56304518
72	STK24	0.55363784
73	PKN1	0.52516559
74	ABL2	0.50855734
75	ERBB4	0.49385672
76	PRKCG	0.49227292
77	PIK3CA	0.48131103
78	BRAF	0.46349879
79	TAOK3	0.46016114
80	CSNK1G1	0.43964280
81	FER	0.43456423
82	TGFBR1	0.43440415
83	EIF2AK2	0.43065110
84	CDK18	0.41532654
85	TIE1	0.41090595
86	ATM	0.41046680
87	ATR	0.39062244
88	AURKB	0.38103693
89	CDK15	0.37960054
90	CDK3	0.37913111
91	SRPK1	0.36313680
92	CSNK1G3	0.35716745
93	MYLK	0.35564315
94	CSNK2A1	0.33374147
95	CSNK1A1L	0.33343340
96	CDK11A	0.31861021
97	PRKCQ	0.31617694
98	PTK2B	0.30266069
99	CAMK1	0.30235582
100	NLK	0.29432910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.40455998
2	Homologous recombination_Homo sapiens_hsa03440	3.17710073
3	Protein export_Homo sapiens_hsa03060	3.16907452
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.80446311
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61424118
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.39315869
7	RNA polymerase_Homo sapiens_hsa03020	2.34440989
8	Basal transcription factors_Homo sapiens_hsa03022	2.27451585
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23505183
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.10000793
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.07871325
12	Mismatch repair_Homo sapiens_hsa03430	2.05121387
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.99400375
14	Collecting duct acid secretion_Homo sapiens_hsa04966	1.86820718
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85889972
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85433201
17	Parkinsons disease_Homo sapiens_hsa05012	1.73120452
18	Propanoate metabolism_Homo sapiens_hsa00640	1.69014366
19	Ribosome_Homo sapiens_hsa03010	1.67222625
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.60496476
21	RNA degradation_Homo sapiens_hsa03018	1.59766747
22	Phototransduction_Homo sapiens_hsa04744	1.58001487
23	Olfactory transduction_Homo sapiens_hsa04740	1.56670090
24	Huntingtons disease_Homo sapiens_hsa05016	1.56276616
25	Caffeine metabolism_Homo sapiens_hsa00232	1.43315544
26	Butanoate metabolism_Homo sapiens_hsa00650	1.27053741
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26581442
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23291880
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.21466141
30	One carbon pool by folate_Homo sapiens_hsa00670	1.14793676
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.12587013
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.12222729
33	Alzheimers disease_Homo sapiens_hsa05010	1.11653406
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09926078
35	RNA transport_Homo sapiens_hsa03013	1.09359891
36	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.08833317
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.06471854
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05684072
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.04921895
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03694396
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02713696
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01549544
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00628484
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99974810
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.99853435
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.98895799
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97848745
48	Mineral absorption_Homo sapiens_hsa04978	0.94149214
49	Folate biosynthesis_Homo sapiens_hsa00790	0.91978906
50	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.90998836
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90968475
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90355131
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.90170433
54	Base excision repair_Homo sapiens_hsa03410	0.87031290
55	Purine metabolism_Homo sapiens_hsa00230	0.85994853
56	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.85399667
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85389325
58	Fatty acid degradation_Homo sapiens_hsa00071	0.84655820
59	Fatty acid elongation_Homo sapiens_hsa00062	0.83892027
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.81883045
61	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81234971
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.81174435
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80877498
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.79737660
65	DNA replication_Homo sapiens_hsa03030	0.78789949
66	Peroxisome_Homo sapiens_hsa04146	0.78361951
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.78198111
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.78029956
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77245693
70	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.76108110
71	Metabolic pathways_Homo sapiens_hsa01100	0.75826584
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.74957202
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.73555169
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72182860
75	Glutathione metabolism_Homo sapiens_hsa00480	0.67644033
76	Retinol metabolism_Homo sapiens_hsa00830	0.66564247
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66199822
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66135432
79	Cell cycle_Homo sapiens_hsa04110	0.63832109
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.63684856
81	Melanoma_Homo sapiens_hsa05218	0.60727219
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58214244
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.58105685
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57704860
85	Regulation of autophagy_Homo sapiens_hsa04140	0.56170694
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55803706
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.55594063
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53015065
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51270035
90	Galactose metabolism_Homo sapiens_hsa00052	0.50858329
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48860144
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48724220
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46640194
94	Circadian rhythm_Homo sapiens_hsa04710	0.45353590
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45023570
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.43950528
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.40920325
98	Complement and coagulation cascades_Homo sapiens_hsa04610	0.40306606
99	p53 signaling pathway_Homo sapiens_hsa04115	0.40262702
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.36882359

HMGB1P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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