HMGB1P24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.26969418
2mitochondrial respiratory chain complex I assembly (GO:0032981)4.34446053
3NADH dehydrogenase complex assembly (GO:0010257)4.34446053
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34446053
5protein complex biogenesis (GO:0070271)4.30234726
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.23435536
7protein-cofactor linkage (GO:0018065)4.12480032
8proteasome assembly (GO:0043248)4.11518410
9mitochondrial respiratory chain complex assembly (GO:0033108)4.11200194
10chromatin remodeling at centromere (GO:0031055)3.91955929
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90954629
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87334313
13DNA double-strand break processing (GO:0000729)3.86521661
14chaperone-mediated protein transport (GO:0072321)3.85669491
15replication fork processing (GO:0031297)3.79605191
16CENP-A containing nucleosome assembly (GO:0034080)3.70211164
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63398072
18ATP synthesis coupled proton transport (GO:0015986)3.63398072
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57620471
20regulation of mitotic spindle checkpoint (GO:1903504)3.57620471
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56426853
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53533789
23DNA replication checkpoint (GO:0000076)3.51938670
24protein neddylation (GO:0045116)3.48192125
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.46836107
26DNA damage response, detection of DNA damage (GO:0042769)3.45516907
27histone exchange (GO:0043486)3.34219597
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32213431
29cytidine metabolic process (GO:0046087)3.29219163
30cytidine catabolic process (GO:0006216)3.29219163
31cytidine deamination (GO:0009972)3.29219163
32kinetochore assembly (GO:0051382)3.27746294
33respiratory electron transport chain (GO:0022904)3.24167373
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.20134589
35termination of RNA polymerase III transcription (GO:0006386)3.20134589
36electron transport chain (GO:0022900)3.19899147
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19833224
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19529570
39resolution of meiotic recombination intermediates (GO:0000712)3.19232997
40regulation of cellular amino acid metabolic process (GO:0006521)3.19203096
41pseudouridine synthesis (GO:0001522)3.14333822
42kinetochore organization (GO:0051383)3.10830445
43water-soluble vitamin biosynthetic process (GO:0042364)3.05637224
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.04104008
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03836995
46centriole replication (GO:0007099)3.03695434
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02026237
48negative regulation of ligase activity (GO:0051352)3.01633977
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01633977
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01470071
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01470071
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01347130
53DNA strand renaturation (GO:0000733)3.00061046
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97394319
55ubiquinone biosynthetic process (GO:0006744)2.96509961
56retinal cone cell development (GO:0046549)2.93694090
57platelet dense granule organization (GO:0060155)2.93237191
58behavioral response to nicotine (GO:0035095)2.92505042
59cullin deneddylation (GO:0010388)2.92059572
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91979818
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91979818
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91979818
63L-methionine salvage (GO:0071267)2.91905537
64L-methionine biosynthetic process (GO:0071265)2.91905537
65amino acid salvage (GO:0043102)2.91905537
66negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90535309
67DNA catabolic process, exonucleolytic (GO:0000738)2.89041052
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88265383
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88265383
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85293546
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82106263
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79639870
73DNA replication-dependent nucleosome organization (GO:0034723)2.78270078
74DNA replication-dependent nucleosome assembly (GO:0006335)2.78270078
75positive regulation of ligase activity (GO:0051351)2.75652337
76signal transduction involved in cell cycle checkpoint (GO:0072395)2.75420700
77respiratory chain complex IV assembly (GO:0008535)2.74186950
78pyrimidine ribonucleoside catabolic process (GO:0046133)2.74122713
79DNA demethylation (GO:0080111)2.74052932
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73256192
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.73256192
82recombinational repair (GO:0000725)2.72348154
83ubiquinone metabolic process (GO:0006743)2.71014843
84tRNA processing (GO:0008033)2.69120277
85synapsis (GO:0007129)2.68632725
86DNA replication-independent nucleosome assembly (GO:0006336)2.68612737
87DNA replication-independent nucleosome organization (GO:0034724)2.68612737
88protein K6-linked ubiquitination (GO:0085020)2.67779828
89double-strand break repair via homologous recombination (GO:0000724)2.67037130
90piRNA metabolic process (GO:0034587)2.66362852
91inner mitochondrial membrane organization (GO:0007007)2.66094918
92L-fucose catabolic process (GO:0042355)2.65167691
93fucose catabolic process (GO:0019317)2.65167691
94L-fucose metabolic process (GO:0042354)2.65167691
95methionine biosynthetic process (GO:0009086)2.64871586
96axoneme assembly (GO:0035082)2.62787590
97organelle disassembly (GO:1903008)2.62473725
98male meiosis I (GO:0007141)2.62400404
99protein deneddylation (GO:0000338)2.61843057
100regulation of mitochondrial translation (GO:0070129)2.61027732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14836589
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.81298535
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39722806
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.28269733
5VDR_22108803_ChIP-Seq_LS180_Human2.99883236
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91147799
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86967413
8ZNF274_21170338_ChIP-Seq_K562_Hela2.76404533
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64145233
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60007112
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41864190
12E2F7_22180533_ChIP-Seq_HELA_Human2.32125091
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30648346
14EWS_26573619_Chip-Seq_HEK293_Human2.29269562
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.26319665
16ELK1_19687146_ChIP-ChIP_HELA_Human2.20752294
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14728553
18VDR_23849224_ChIP-Seq_CD4+_Human2.12286773
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07549142
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.07242565
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.00857230
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97584283
23GBX2_23144817_ChIP-Seq_PC3_Human1.95546966
24FUS_26573619_Chip-Seq_HEK293_Human1.91987346
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90627524
26MYC_18940864_ChIP-ChIP_HL60_Human1.89030636
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88583468
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88322245
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86700715
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80433087
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79382925
32IGF1R_20145208_ChIP-Seq_DFB_Human1.74339050
33P300_19829295_ChIP-Seq_ESCs_Human1.73500496
34IRF1_19129219_ChIP-ChIP_H3396_Human1.72274032
35EZH2_22144423_ChIP-Seq_EOC_Human1.63552882
36FOXP3_21729870_ChIP-Seq_TREG_Human1.62706049
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60563393
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60158760
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55014132
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.50063658
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49261097
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48071464
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.46714352
44TAF15_26573619_Chip-Seq_HEK293_Human1.42659818
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40723988
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36949066
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.35937673
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35909566
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32660129
50TP53_22573176_ChIP-Seq_HFKS_Human1.31992053
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30764897
52ER_23166858_ChIP-Seq_MCF-7_Human1.30471779
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.28667349
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.26511940
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25168866
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23871841
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21739913
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18883953
59CBP_20019798_ChIP-Seq_JUKART_Human1.18883953
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18021405
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17716003
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15604000
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12170060
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11470294
65NANOG_19829295_ChIP-Seq_ESCs_Human1.10440823
66SOX2_19829295_ChIP-Seq_ESCs_Human1.10440823
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09570799
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09057205
69TTF2_22483619_ChIP-Seq_HELA_Human1.08017086
70GABP_19822575_ChIP-Seq_HepG2_Human1.05677200
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04499064
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02789298
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00925794
74RNF2_27304074_Chip-Seq_NSC_Mouse1.00161215
75MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99703928
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99060436
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.99060436
78HTT_18923047_ChIP-ChIP_STHdh_Human0.98786239
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98713856
80NANOG_16153702_ChIP-ChIP_HESCs_Human0.97724718
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97355984
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97256552
83TCF4_22108803_ChIP-Seq_LS180_Human0.97040157
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96696460
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96242192
86SMAD4_21799915_ChIP-Seq_A2780_Human0.95601411
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.94127736
88BCAT_22108803_ChIP-Seq_LS180_Human0.93710781
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93404398
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92498596
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.92341485
92DCP1A_22483619_ChIP-Seq_HELA_Human0.92296297
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.91690925
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91621318
95PHF8_20622853_ChIP-Seq_HELA_Human0.91533264
96NCOR_22424771_ChIP-Seq_293T_Human0.90287529
97AR_20517297_ChIP-Seq_VCAP_Human0.89658209
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88419368
99RBPJ_21746931_ChIP-Seq_IB4_Human0.88352149
100HOXB7_26014856_ChIP-Seq_BT474_Human0.87961225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.07471717
2MP0008877_abnormal_DNA_methylation3.50807175
3MP0004147_increased_porphyrin_level2.78151165
4MP0008058_abnormal_DNA_repair2.61460168
5MP0002102_abnormal_ear_morphology2.36676241
6MP0010094_abnormal_chromosome_stability2.09809598
7MP0003787_abnormal_imprinting2.04321417
8MP0003786_premature_aging2.00987899
9MP0002938_white_spotting1.99973406
10MP0002736_abnormal_nociception_after1.98109286
11MP0005551_abnormal_eye_electrophysiolog1.97873329
12MP0005646_abnormal_pituitary_gland1.93245765
13MP0000372_irregular_coat_pigmentation1.92954073
14MP0008875_abnormal_xenobiotic_pharmacok1.86992460
15MP0006276_abnormal_autonomic_nervous1.85857647
16MP0006072_abnormal_retinal_apoptosis1.85370753
17MP0003693_abnormal_embryo_hatching1.75476988
18MP0004142_abnormal_muscle_tone1.71913604
19MP0008872_abnormal_physiological_respon1.69864566
20MP0003718_maternal_effect1.69293808
21MP0003567_abnormal_fetal_cardiomyocyte1.62612368
22MP0000647_abnormal_sebaceous_gland1.60279268
23MP0003195_calcinosis1.59110481
24MP0001293_anophthalmia1.59103350
25MP0001984_abnormal_olfaction1.58982808
26MP0002277_abnormal_respiratory_mucosa1.58442304
27MP0001968_abnormal_touch/_nociception1.56883173
28MP0004145_abnormal_muscle_electrophysio1.56539662
29MP0009046_muscle_twitch1.54823626
30MP0008789_abnormal_olfactory_epithelium1.54709728
31MP0003121_genomic_imprinting1.54204615
32MP0002837_dystrophic_cardiac_calcinosis1.53950055
33MP0005253_abnormal_eye_physiology1.52912280
34MP0001529_abnormal_vocalization1.46025699
35MP0000049_abnormal_middle_ear1.42627926
36MP0002272_abnormal_nervous_system1.41671751
37MP0009379_abnormal_foot_pigmentation1.41364956
38MP0003011_delayed_dark_adaptation1.40552147
39MP0001485_abnormal_pinna_reflex1.38130686
40MP0003122_maternal_imprinting1.34713048
41MP0002638_abnormal_pupillary_reflex1.34391869
42MP0006035_abnormal_mitochondrial_morpho1.34299940
43MP0005084_abnormal_gallbladder_morpholo1.34260894
44MP0003136_yellow_coat_color1.34053455
45MP0000569_abnormal_digit_pigmentation1.31842241
46MP0005174_abnormal_tail_pigmentation1.30013192
47MP0003186_abnormal_redox_activity1.28313553
48MP0001486_abnormal_startle_reflex1.28237498
49MP0008995_early_reproductive_senescence1.27769776
50MP0006036_abnormal_mitochondrial_physio1.25981808
51MP0003646_muscle_fatigue1.25699730
52MP0009745_abnormal_behavioral_response1.23322332
53MP0001929_abnormal_gametogenesis1.22422619
54MP0002210_abnormal_sex_determination1.18908302
55MP0003111_abnormal_nucleus_morphology1.18058995
56MP0001188_hyperpigmentation1.16293319
57MP0001502_abnormal_circadian_rhythm1.12875812
58MP0002234_abnormal_pharynx_morphology1.11899421
59MP0002095_abnormal_skin_pigmentation1.11518322
60MP0004742_abnormal_vestibular_system1.11236800
61MP0003937_abnormal_limbs/digits/tail_de1.10183865
62MP0000631_abnormal_neuroendocrine_gland1.08815153
63MP0005410_abnormal_fertilization1.07417420
64MP0003880_abnormal_central_pattern1.07306076
65MP0005645_abnormal_hypothalamus_physiol1.06652149
66MP0001905_abnormal_dopamine_level1.05652144
67MP0001970_abnormal_pain_threshold1.05011191
68MP0005389_reproductive_system_phenotype1.04051614
69MP0002733_abnormal_thermal_nociception1.02048796
70MP0003938_abnormal_ear_development1.01864775
71MP0002751_abnormal_autonomic_nervous1.01630380
72MP0004885_abnormal_endolymph1.01384658
73MP0002139_abnormal_hepatobiliary_system1.01123357
74MP0002557_abnormal_social/conspecific_i1.00832233
75MP0001919_abnormal_reproductive_system0.96519515
76MP0003698_abnormal_male_reproductive0.95584306
77MP0005499_abnormal_olfactory_system0.94654128
78MP0005394_taste/olfaction_phenotype0.94654128
79MP0004133_heterotaxia0.94576865
80MP0002876_abnormal_thyroid_physiology0.92740401
81MP0000653_abnormal_sex_gland0.92157338
82MP0001764_abnormal_homeostasis0.91067326
83MP0001145_abnormal_male_reproductive0.89962273
84MP0008007_abnormal_cellular_replicative0.89135747
85MP0002233_abnormal_nose_morphology0.88321599
86MP0001963_abnormal_hearing_physiology0.87647798
87MP0002735_abnormal_chemical_nociception0.87321260
88MP0002160_abnormal_reproductive_system0.86754583
89MP0004957_abnormal_blastocyst_morpholog0.85971760
90MP0001986_abnormal_taste_sensitivity0.84872289
91MP0005195_abnormal_posterior_eye0.84171455
92MP0002572_abnormal_emotion/affect_behav0.82343349
93MP0002653_abnormal_ependyma_morphology0.81632580
94MP0000427_abnormal_hair_cycle0.81348802
95MP0000026_abnormal_inner_ear0.81019312
96MP0003077_abnormal_cell_cycle0.80794012
97MP0005671_abnormal_response_to0.79457513
98MP0005391_vision/eye_phenotype0.79184596
99MP0002734_abnormal_mechanical_nocicepti0.77768187
100MP0002163_abnormal_gland_morphology0.77551417

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.43327869
2Acute encephalopathy (HP:0006846)3.93275006
3Abnormal mitochondria in muscle tissue (HP:0008316)3.83290903
4Progressive macrocephaly (HP:0004481)3.73768568
5Mitochondrial inheritance (HP:0001427)3.66187836
6Abnormality of midbrain morphology (HP:0002418)3.45048801
7Molar tooth sign on MRI (HP:0002419)3.45048801
8Increased CSF lactate (HP:0002490)3.44298725
9True hermaphroditism (HP:0010459)3.35750806
10Abnormality of the labia minora (HP:0012880)3.35195439
11Increased hepatocellular lipid droplets (HP:0006565)3.32686585
123-Methylglutaconic aciduria (HP:0003535)3.31975042
13Lipid accumulation in hepatocytes (HP:0006561)3.21895123
14Pancreatic cysts (HP:0001737)3.21756329
15Pancreatic fibrosis (HP:0100732)3.05310687
16Nephronophthisis (HP:0000090)2.99433116
17Cerebral edema (HP:0002181)2.78641590
18Colon cancer (HP:0003003)2.66539380
19Hepatocellular necrosis (HP:0001404)2.63966069
20Congenital stationary night blindness (HP:0007642)2.62585904
21Type II lissencephaly (HP:0007260)2.54059572
22Increased serum lactate (HP:0002151)2.50325330
23Renal Fanconi syndrome (HP:0001994)2.47992205
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.45520109
25Methylmalonic aciduria (HP:0012120)2.44032679
26Methylmalonic acidemia (HP:0002912)2.42468680
27Hypoplasia of the pons (HP:0012110)2.42026545
28Pendular nystagmus (HP:0012043)2.41369353
29Hyperglycinemia (HP:0002154)2.39840588
30Abnormality of chromosome stability (HP:0003220)2.39789249
31Abnormality of the pons (HP:0007361)2.37543644
32Medial flaring of the eyebrow (HP:0010747)2.36908620
33Abnormality of the renal medulla (HP:0100957)2.36098889
34Hepatic necrosis (HP:0002605)2.35829194
35Meckel diverticulum (HP:0002245)2.33936304
36Abnormality of the ileum (HP:0001549)2.32475622
37Optic disc pallor (HP:0000543)2.25605969
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25030381
39Lactic acidosis (HP:0003128)2.18131550
40Increased intramyocellular lipid droplets (HP:0012240)2.14210711
41Reticulocytopenia (HP:0001896)2.13721824
42Birth length less than 3rd percentile (HP:0003561)2.12772588
43Aplastic anemia (HP:0001915)2.12650798
44Abolished electroretinogram (ERG) (HP:0000550)2.12512896
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10335964
46Anencephaly (HP:0002323)2.09434019
47Absent thumb (HP:0009777)2.08246539
48Abnormality of alanine metabolism (HP:0010916)2.05381574
49Hyperalaninemia (HP:0003348)2.05381574
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05381574
51Sclerocornea (HP:0000647)2.03181213
52Volvulus (HP:0002580)2.02999778
53Exertional dyspnea (HP:0002875)2.02594364
54Lethargy (HP:0001254)2.00182390
55Abnormality of DNA repair (HP:0003254)1.98674663
56Postaxial foot polydactyly (HP:0001830)1.95063462
57Leukodystrophy (HP:0002415)1.93745805
58Abnormality of the phalanges of the 5th finger (HP:0004213)1.92672517
59Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89860358
60Aplasia/Hypoplasia of the tongue (HP:0010295)1.89257826
61Chromsome breakage (HP:0040012)1.88762148
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88702648
63Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88702648
64Abnormality of the renal cortex (HP:0011035)1.86178828
65Pancytopenia (HP:0001876)1.85489893
66Cerebral hypomyelination (HP:0006808)1.85220433
67Male pseudohermaphroditism (HP:0000037)1.84645925
68Ectopic kidney (HP:0000086)1.84102868
69Abnormality of serum amino acid levels (HP:0003112)1.84007627
70Focal motor seizures (HP:0011153)1.83910790
71Clubbing of toes (HP:0100760)1.83845044
72Small hand (HP:0200055)1.83290976
73Thyroid-stimulating hormone excess (HP:0002925)1.82991842
74Oligodactyly (HP:0012165)1.81493802
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81155080
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80920412
77Microvesicular hepatic steatosis (HP:0001414)1.80062524
78Pancreatic islet-cell hyperplasia (HP:0004510)1.79433637
79Abnormal rod and cone electroretinograms (HP:0008323)1.78273778
80Respiratory failure (HP:0002878)1.78258939
81Abnormality of the preputium (HP:0100587)1.77831928
82Oligodactyly (hands) (HP:0001180)1.77482675
83Sloping forehead (HP:0000340)1.77314736
84Febrile seizures (HP:0002373)1.76420327
85Exercise intolerance (HP:0003546)1.75919633
86Congenital, generalized hypertrichosis (HP:0004540)1.75818393
87Gait imbalance (HP:0002141)1.74618901
88Abnormal number of incisors (HP:0011064)1.73622930
89Cystic liver disease (HP:0006706)1.73450852
90Atonic seizures (HP:0010819)1.73172893
91Aplasia/Hypoplasia of the patella (HP:0006498)1.72595401
92Congenital primary aphakia (HP:0007707)1.72181067
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.71499608
94Increased muscle lipid content (HP:0009058)1.70486769
95Abnormal hair whorl (HP:0010721)1.70368884
96Abnormality of renal resorption (HP:0011038)1.70232132
97Lissencephaly (HP:0001339)1.68565850
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66959382
99Supernumerary spleens (HP:0009799)1.65846069
100Patellar aplasia (HP:0006443)1.65578853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B2.91973115
2STK162.58785723
3FRK2.57675302
4CDC72.55943027
5MAP4K22.45338009
6ZAK2.39153736
7VRK22.33639159
8WNK32.21278063
9PLK42.13571628
10MKNK22.07650689
11GRK12.03660375
12VRK12.02377996
13SRPK12.01534644
14WEE12.00113374
15BUB11.98726892
16ADRBK21.96340786
17WNK41.94418794
18PLK21.94167173
19INSRR1.94159968
20MST41.90013181
21TLK11.87882056
22TAOK31.87031223
23NUAK11.83753236
24CASK1.83384449
25TRIM281.65806290
26MAPK131.63366282
27BRSK21.55759512
28PLK31.52707164
29BCKDK1.31436027
30STK391.31364372
31PINK11.31195852
32TIE11.28573536
33MAP3K121.26415964
34DYRK21.25997146
35TNIK1.23598201
36TSSK61.20667802
37MKNK11.18620456
38PLK11.10955854
39TTK1.10430080
40GRK71.07284126
41OXSR11.04224934
42TXK1.01856267
43ACVR1B0.91641522
44NEK10.89838912
45PNCK0.89769509
46CSNK1G10.87759245
47TEC0.87089093
48AURKB0.83969048
49MARK10.81410332
50ATR0.79377657
51TAF10.77588990
52PAK30.75381111
53RPS6KA40.74952355
54CCNB10.72956342
55PRKCG0.71827353
56RPS6KA50.70150785
57EIF2AK10.69196205
58AURKA0.68028322
59BRSK10.65891264
60PDK20.63534340
61ERBB30.63331715
62PIK3CA0.63052835
63PRKCQ0.62837076
64ADRBK10.62725644
65BCR0.60499644
66MUSK0.57639454
67CSNK1G30.56743364
68TGFBR10.55071360
69CDK30.54358458
70CDK80.54095404
71GRK50.53039287
72PRKCE0.52595538
73CSNK1G20.51642699
74PBK0.51334739
75EIF2AK20.51282189
76PKN10.50411802
77MATK0.48854024
78EIF2AK30.48573463
79CAMK10.48403566
80NTRK30.48138807
81MINK10.48135008
82KDR0.47507692
83EPHA40.46823201
84CHEK20.46549144
85CSNK1A10.45633983
86NME10.45519360
87ATM0.45344036
88CSNK2A20.44455302
89ERBB20.43789176
90CAMK2A0.43598203
91MAP3K40.43286398
92CSNK1E0.42724658
93CSNK2A10.42163796
94CLK10.39824084
95IKBKB0.38898768
96PTK2B0.38743949
97ROCK10.38563456
98PRKACA0.37999726
99ITK0.36775458
100CSNK1A1L0.36029117

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04476915
2Oxidative phosphorylation_Homo sapiens_hsa001903.10702029
3Protein export_Homo sapiens_hsa030603.04640411
4Homologous recombination_Homo sapiens_hsa034402.71914997
5Parkinsons disease_Homo sapiens_hsa050122.63363461
6RNA polymerase_Homo sapiens_hsa030202.59654755
7One carbon pool by folate_Homo sapiens_hsa006702.21651035
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21509791
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15137012
10Fanconi anemia pathway_Homo sapiens_hsa034602.14556101
11Ribosome_Homo sapiens_hsa030102.12232318
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10118927
13Steroid biosynthesis_Homo sapiens_hsa001002.02935029
14Basal transcription factors_Homo sapiens_hsa030221.95360451
15Huntingtons disease_Homo sapiens_hsa050161.95236633
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80964247
17Mismatch repair_Homo sapiens_hsa034301.77112342
18DNA replication_Homo sapiens_hsa030301.70595276
19Phototransduction_Homo sapiens_hsa047441.67910486
20RNA degradation_Homo sapiens_hsa030181.64950375
21Non-homologous end-joining_Homo sapiens_hsa034501.55433171
22Nucleotide excision repair_Homo sapiens_hsa034201.54439519
23Propanoate metabolism_Homo sapiens_hsa006401.52828775
24Spliceosome_Homo sapiens_hsa030401.51596980
25Alzheimers disease_Homo sapiens_hsa050101.50680703
26Butanoate metabolism_Homo sapiens_hsa006501.44995503
27Base excision repair_Homo sapiens_hsa034101.41364196
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40667418
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38308941
30Asthma_Homo sapiens_hsa053101.35456639
31RNA transport_Homo sapiens_hsa030131.32331880
32Linoleic acid metabolism_Homo sapiens_hsa005911.31547339
33Cardiac muscle contraction_Homo sapiens_hsa042601.31327268
34Pyrimidine metabolism_Homo sapiens_hsa002401.25092198
35Nitrogen metabolism_Homo sapiens_hsa009101.25066675
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.24595712
37Selenocompound metabolism_Homo sapiens_hsa004501.23158436
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.20554782
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13238343
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08882501
41Purine metabolism_Homo sapiens_hsa002301.08510524
42Nicotine addiction_Homo sapiens_hsa050331.07608276
43Caffeine metabolism_Homo sapiens_hsa002321.07013946
44Autoimmune thyroid disease_Homo sapiens_hsa053201.06391685
45Folate biosynthesis_Homo sapiens_hsa007901.06143367
46Allograft rejection_Homo sapiens_hsa053301.02778089
47Primary immunodeficiency_Homo sapiens_hsa053401.02289804
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00308009
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98302720
50beta-Alanine metabolism_Homo sapiens_hsa004100.96773924
51Graft-versus-host disease_Homo sapiens_hsa053320.95442347
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94759138
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94090654
54Fatty acid elongation_Homo sapiens_hsa000620.93801999
55Tryptophan metabolism_Homo sapiens_hsa003800.92194718
56Ether lipid metabolism_Homo sapiens_hsa005650.90402103
57Olfactory transduction_Homo sapiens_hsa047400.88956172
58Type I diabetes mellitus_Homo sapiens_hsa049400.87690254
59Sulfur relay system_Homo sapiens_hsa041220.86469308
60Peroxisome_Homo sapiens_hsa041460.83016147
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81182543
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80599691
63Taste transduction_Homo sapiens_hsa047420.77938362
64Systemic lupus erythematosus_Homo sapiens_hsa053220.72063923
65Fat digestion and absorption_Homo sapiens_hsa049750.70488173
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68751349
67Retinol metabolism_Homo sapiens_hsa008300.68684210
68Metabolic pathways_Homo sapiens_hsa011000.68086353
69Pyruvate metabolism_Homo sapiens_hsa006200.67548187
70Chemical carcinogenesis_Homo sapiens_hsa052040.67519329
71Glutathione metabolism_Homo sapiens_hsa004800.66537383
72Antigen processing and presentation_Homo sapiens_hsa046120.65954268
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65446812
74Cell cycle_Homo sapiens_hsa041100.61357243
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58207096
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58036706
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56320663
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52598404
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.52058701
80Rheumatoid arthritis_Homo sapiens_hsa053230.51159755
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48566654
82Collecting duct acid secretion_Homo sapiens_hsa049660.48235878
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47102611
84Vitamin digestion and absorption_Homo sapiens_hsa049770.46968498
85Oocyte meiosis_Homo sapiens_hsa041140.46685901
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44382013
87Fatty acid metabolism_Homo sapiens_hsa012120.44153714
88Regulation of autophagy_Homo sapiens_hsa041400.42766598
89ABC transporters_Homo sapiens_hsa020100.40742185
90p53 signaling pathway_Homo sapiens_hsa041150.40079503
91Tyrosine metabolism_Homo sapiens_hsa003500.39584399
92Fatty acid degradation_Homo sapiens_hsa000710.39053644
93Glycerolipid metabolism_Homo sapiens_hsa005610.35003491
94mRNA surveillance pathway_Homo sapiens_hsa030150.32684501
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30914055
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30712733
97Circadian rhythm_Homo sapiens_hsa047100.30260231
98Insulin secretion_Homo sapiens_hsa049110.29526890
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29487978
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27098042

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