Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 5.26969418 |
2 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.34446053 |
3 | NADH dehydrogenase complex assembly (GO:0010257) | 4.34446053 |
4 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.34446053 |
5 | protein complex biogenesis (GO:0070271) | 4.30234726 |
6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.23435536 |
7 | protein-cofactor linkage (GO:0018065) | 4.12480032 |
8 | proteasome assembly (GO:0043248) | 4.11518410 |
9 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.11200194 |
10 | chromatin remodeling at centromere (GO:0031055) | 3.91955929 |
11 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.90954629 |
12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.87334313 |
13 | DNA double-strand break processing (GO:0000729) | 3.86521661 |
14 | chaperone-mediated protein transport (GO:0072321) | 3.85669491 |
15 | replication fork processing (GO:0031297) | 3.79605191 |
16 | CENP-A containing nucleosome assembly (GO:0034080) | 3.70211164 |
17 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.63398072 |
18 | ATP synthesis coupled proton transport (GO:0015986) | 3.63398072 |
19 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.57620471 |
20 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.57620471 |
21 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.56426853 |
22 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.53533789 |
23 | DNA replication checkpoint (GO:0000076) | 3.51938670 |
24 | protein neddylation (GO:0045116) | 3.48192125 |
25 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.46836107 |
26 | DNA damage response, detection of DNA damage (GO:0042769) | 3.45516907 |
27 | histone exchange (GO:0043486) | 3.34219597 |
28 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.32213431 |
29 | cytidine metabolic process (GO:0046087) | 3.29219163 |
30 | cytidine catabolic process (GO:0006216) | 3.29219163 |
31 | cytidine deamination (GO:0009972) | 3.29219163 |
32 | kinetochore assembly (GO:0051382) | 3.27746294 |
33 | respiratory electron transport chain (GO:0022904) | 3.24167373 |
34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.20134589 |
35 | termination of RNA polymerase III transcription (GO:0006386) | 3.20134589 |
36 | electron transport chain (GO:0022900) | 3.19899147 |
37 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.19833224 |
38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.19529570 |
39 | resolution of meiotic recombination intermediates (GO:0000712) | 3.19232997 |
40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.19203096 |
41 | pseudouridine synthesis (GO:0001522) | 3.14333822 |
42 | kinetochore organization (GO:0051383) | 3.10830445 |
43 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.05637224 |
44 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.04104008 |
45 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.03836995 |
46 | centriole replication (GO:0007099) | 3.03695434 |
47 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.02026237 |
48 | negative regulation of ligase activity (GO:0051352) | 3.01633977 |
49 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.01633977 |
50 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.01470071 |
51 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.01470071 |
52 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.01347130 |
53 | DNA strand renaturation (GO:0000733) | 3.00061046 |
54 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.97394319 |
55 | ubiquinone biosynthetic process (GO:0006744) | 2.96509961 |
56 | retinal cone cell development (GO:0046549) | 2.93694090 |
57 | platelet dense granule organization (GO:0060155) | 2.93237191 |
58 | behavioral response to nicotine (GO:0035095) | 2.92505042 |
59 | cullin deneddylation (GO:0010388) | 2.92059572 |
60 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.91979818 |
61 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.91979818 |
62 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.91979818 |
63 | L-methionine salvage (GO:0071267) | 2.91905537 |
64 | L-methionine biosynthetic process (GO:0071265) | 2.91905537 |
65 | amino acid salvage (GO:0043102) | 2.91905537 |
66 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.90535309 |
67 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.89041052 |
68 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.88265383 |
69 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.88265383 |
70 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.85293546 |
71 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.82106263 |
72 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.79639870 |
73 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.78270078 |
74 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.78270078 |
75 | positive regulation of ligase activity (GO:0051351) | 2.75652337 |
76 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.75420700 |
77 | respiratory chain complex IV assembly (GO:0008535) | 2.74186950 |
78 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.74122713 |
79 | DNA demethylation (GO:0080111) | 2.74052932 |
80 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.73256192 |
81 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.73256192 |
82 | recombinational repair (GO:0000725) | 2.72348154 |
83 | ubiquinone metabolic process (GO:0006743) | 2.71014843 |
84 | tRNA processing (GO:0008033) | 2.69120277 |
85 | synapsis (GO:0007129) | 2.68632725 |
86 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.68612737 |
87 | DNA replication-independent nucleosome organization (GO:0034724) | 2.68612737 |
88 | protein K6-linked ubiquitination (GO:0085020) | 2.67779828 |
89 | double-strand break repair via homologous recombination (GO:0000724) | 2.67037130 |
90 | piRNA metabolic process (GO:0034587) | 2.66362852 |
91 | inner mitochondrial membrane organization (GO:0007007) | 2.66094918 |
92 | L-fucose catabolic process (GO:0042355) | 2.65167691 |
93 | fucose catabolic process (GO:0019317) | 2.65167691 |
94 | L-fucose metabolic process (GO:0042354) | 2.65167691 |
95 | methionine biosynthetic process (GO:0009086) | 2.64871586 |
96 | axoneme assembly (GO:0035082) | 2.62787590 |
97 | organelle disassembly (GO:1903008) | 2.62473725 |
98 | male meiosis I (GO:0007141) | 2.62400404 |
99 | protein deneddylation (GO:0000338) | 2.61843057 |
100 | regulation of mitochondrial translation (GO:0070129) | 2.61027732 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.14836589 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.81298535 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.39722806 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.28269733 |
5 | VDR_22108803_ChIP-Seq_LS180_Human | 2.99883236 |
6 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.91147799 |
7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.86967413 |
8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.76404533 |
9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.64145233 |
10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.60007112 |
11 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.41864190 |
12 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.32125091 |
13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.30648346 |
14 | EWS_26573619_Chip-Seq_HEK293_Human | 2.29269562 |
15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.26319665 |
16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.20752294 |
17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.14728553 |
18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.12286773 |
19 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.07549142 |
20 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.07242565 |
21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.00857230 |
22 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.97584283 |
23 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.95546966 |
24 | FUS_26573619_Chip-Seq_HEK293_Human | 1.91987346 |
25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.90627524 |
26 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.89030636 |
27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.88583468 |
28 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.88322245 |
29 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.86700715 |
30 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.80433087 |
31 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.79382925 |
32 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.74339050 |
33 | P300_19829295_ChIP-Seq_ESCs_Human | 1.73500496 |
34 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.72274032 |
35 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.63552882 |
36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.62706049 |
37 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.60563393 |
38 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.60158760 |
39 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.55014132 |
40 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.50063658 |
41 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.49261097 |
42 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.48071464 |
43 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.46714352 |
44 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.42659818 |
45 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.40723988 |
46 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.36949066 |
47 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.35937673 |
48 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.35909566 |
49 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.32660129 |
50 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.31992053 |
51 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.30764897 |
52 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.30471779 |
53 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.28667349 |
54 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.26511940 |
55 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.25168866 |
56 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.23871841 |
57 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.21739913 |
58 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.18883953 |
59 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.18883953 |
60 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.18021405 |
61 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.17716003 |
62 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.15604000 |
63 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.12170060 |
64 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.11470294 |
65 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.10440823 |
66 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.10440823 |
67 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.09570799 |
68 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.09057205 |
69 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.08017086 |
70 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.05677200 |
71 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.04499064 |
72 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.02789298 |
73 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.00925794 |
74 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.00161215 |
75 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.99703928 |
76 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.99060436 |
77 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.99060436 |
78 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.98786239 |
79 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.98713856 |
80 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.97724718 |
81 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.97355984 |
82 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.97256552 |
83 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.97040157 |
84 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.96696460 |
85 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.96242192 |
86 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.95601411 |
87 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.94127736 |
88 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.93710781 |
89 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.93404398 |
90 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.92498596 |
91 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.92341485 |
92 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.92296297 |
93 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.91690925 |
94 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.91621318 |
95 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.91533264 |
96 | NCOR_22424771_ChIP-Seq_293T_Human | 0.90287529 |
97 | AR_20517297_ChIP-Seq_VCAP_Human | 0.89658209 |
98 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.88419368 |
99 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.88352149 |
100 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.87961225 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0006292_abnormal_olfactory_placode | 4.07471717 |
2 | MP0008877_abnormal_DNA_methylation | 3.50807175 |
3 | MP0004147_increased_porphyrin_level | 2.78151165 |
4 | MP0008058_abnormal_DNA_repair | 2.61460168 |
5 | MP0002102_abnormal_ear_morphology | 2.36676241 |
6 | MP0010094_abnormal_chromosome_stability | 2.09809598 |
7 | MP0003787_abnormal_imprinting | 2.04321417 |
8 | MP0003786_premature_aging | 2.00987899 |
9 | MP0002938_white_spotting | 1.99973406 |
10 | MP0002736_abnormal_nociception_after | 1.98109286 |
11 | MP0005551_abnormal_eye_electrophysiolog | 1.97873329 |
12 | MP0005646_abnormal_pituitary_gland | 1.93245765 |
13 | MP0000372_irregular_coat_pigmentation | 1.92954073 |
14 | MP0008875_abnormal_xenobiotic_pharmacok | 1.86992460 |
15 | MP0006276_abnormal_autonomic_nervous | 1.85857647 |
16 | MP0006072_abnormal_retinal_apoptosis | 1.85370753 |
17 | MP0003693_abnormal_embryo_hatching | 1.75476988 |
18 | MP0004142_abnormal_muscle_tone | 1.71913604 |
19 | MP0008872_abnormal_physiological_respon | 1.69864566 |
20 | MP0003718_maternal_effect | 1.69293808 |
21 | MP0003567_abnormal_fetal_cardiomyocyte | 1.62612368 |
22 | MP0000647_abnormal_sebaceous_gland | 1.60279268 |
23 | MP0003195_calcinosis | 1.59110481 |
24 | MP0001293_anophthalmia | 1.59103350 |
25 | MP0001984_abnormal_olfaction | 1.58982808 |
26 | MP0002277_abnormal_respiratory_mucosa | 1.58442304 |
27 | MP0001968_abnormal_touch/_nociception | 1.56883173 |
28 | MP0004145_abnormal_muscle_electrophysio | 1.56539662 |
29 | MP0009046_muscle_twitch | 1.54823626 |
30 | MP0008789_abnormal_olfactory_epithelium | 1.54709728 |
31 | MP0003121_genomic_imprinting | 1.54204615 |
32 | MP0002837_dystrophic_cardiac_calcinosis | 1.53950055 |
33 | MP0005253_abnormal_eye_physiology | 1.52912280 |
34 | MP0001529_abnormal_vocalization | 1.46025699 |
35 | MP0000049_abnormal_middle_ear | 1.42627926 |
36 | MP0002272_abnormal_nervous_system | 1.41671751 |
37 | MP0009379_abnormal_foot_pigmentation | 1.41364956 |
38 | MP0003011_delayed_dark_adaptation | 1.40552147 |
39 | MP0001485_abnormal_pinna_reflex | 1.38130686 |
40 | MP0003122_maternal_imprinting | 1.34713048 |
41 | MP0002638_abnormal_pupillary_reflex | 1.34391869 |
42 | MP0006035_abnormal_mitochondrial_morpho | 1.34299940 |
43 | MP0005084_abnormal_gallbladder_morpholo | 1.34260894 |
44 | MP0003136_yellow_coat_color | 1.34053455 |
45 | MP0000569_abnormal_digit_pigmentation | 1.31842241 |
46 | MP0005174_abnormal_tail_pigmentation | 1.30013192 |
47 | MP0003186_abnormal_redox_activity | 1.28313553 |
48 | MP0001486_abnormal_startle_reflex | 1.28237498 |
49 | MP0008995_early_reproductive_senescence | 1.27769776 |
50 | MP0006036_abnormal_mitochondrial_physio | 1.25981808 |
51 | MP0003646_muscle_fatigue | 1.25699730 |
52 | MP0009745_abnormal_behavioral_response | 1.23322332 |
53 | MP0001929_abnormal_gametogenesis | 1.22422619 |
54 | MP0002210_abnormal_sex_determination | 1.18908302 |
55 | MP0003111_abnormal_nucleus_morphology | 1.18058995 |
56 | MP0001188_hyperpigmentation | 1.16293319 |
57 | MP0001502_abnormal_circadian_rhythm | 1.12875812 |
58 | MP0002234_abnormal_pharynx_morphology | 1.11899421 |
59 | MP0002095_abnormal_skin_pigmentation | 1.11518322 |
60 | MP0004742_abnormal_vestibular_system | 1.11236800 |
61 | MP0003937_abnormal_limbs/digits/tail_de | 1.10183865 |
62 | MP0000631_abnormal_neuroendocrine_gland | 1.08815153 |
63 | MP0005410_abnormal_fertilization | 1.07417420 |
64 | MP0003880_abnormal_central_pattern | 1.07306076 |
65 | MP0005645_abnormal_hypothalamus_physiol | 1.06652149 |
66 | MP0001905_abnormal_dopamine_level | 1.05652144 |
67 | MP0001970_abnormal_pain_threshold | 1.05011191 |
68 | MP0005389_reproductive_system_phenotype | 1.04051614 |
69 | MP0002733_abnormal_thermal_nociception | 1.02048796 |
70 | MP0003938_abnormal_ear_development | 1.01864775 |
71 | MP0002751_abnormal_autonomic_nervous | 1.01630380 |
72 | MP0004885_abnormal_endolymph | 1.01384658 |
73 | MP0002139_abnormal_hepatobiliary_system | 1.01123357 |
74 | MP0002557_abnormal_social/conspecific_i | 1.00832233 |
75 | MP0001919_abnormal_reproductive_system | 0.96519515 |
76 | MP0003698_abnormal_male_reproductive | 0.95584306 |
77 | MP0005499_abnormal_olfactory_system | 0.94654128 |
78 | MP0005394_taste/olfaction_phenotype | 0.94654128 |
79 | MP0004133_heterotaxia | 0.94576865 |
80 | MP0002876_abnormal_thyroid_physiology | 0.92740401 |
81 | MP0000653_abnormal_sex_gland | 0.92157338 |
82 | MP0001764_abnormal_homeostasis | 0.91067326 |
83 | MP0001145_abnormal_male_reproductive | 0.89962273 |
84 | MP0008007_abnormal_cellular_replicative | 0.89135747 |
85 | MP0002233_abnormal_nose_morphology | 0.88321599 |
86 | MP0001963_abnormal_hearing_physiology | 0.87647798 |
87 | MP0002735_abnormal_chemical_nociception | 0.87321260 |
88 | MP0002160_abnormal_reproductive_system | 0.86754583 |
89 | MP0004957_abnormal_blastocyst_morpholog | 0.85971760 |
90 | MP0001986_abnormal_taste_sensitivity | 0.84872289 |
91 | MP0005195_abnormal_posterior_eye | 0.84171455 |
92 | MP0002572_abnormal_emotion/affect_behav | 0.82343349 |
93 | MP0002653_abnormal_ependyma_morphology | 0.81632580 |
94 | MP0000427_abnormal_hair_cycle | 0.81348802 |
95 | MP0000026_abnormal_inner_ear | 0.81019312 |
96 | MP0003077_abnormal_cell_cycle | 0.80794012 |
97 | MP0005671_abnormal_response_to | 0.79457513 |
98 | MP0005391_vision/eye_phenotype | 0.79184596 |
99 | MP0002734_abnormal_mechanical_nocicepti | 0.77768187 |
100 | MP0002163_abnormal_gland_morphology | 0.77551417 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.43327869 |
2 | Acute encephalopathy (HP:0006846) | 3.93275006 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.83290903 |
4 | Progressive macrocephaly (HP:0004481) | 3.73768568 |
5 | Mitochondrial inheritance (HP:0001427) | 3.66187836 |
6 | Abnormality of midbrain morphology (HP:0002418) | 3.45048801 |
7 | Molar tooth sign on MRI (HP:0002419) | 3.45048801 |
8 | Increased CSF lactate (HP:0002490) | 3.44298725 |
9 | True hermaphroditism (HP:0010459) | 3.35750806 |
10 | Abnormality of the labia minora (HP:0012880) | 3.35195439 |
11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.32686585 |
12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.31975042 |
13 | Lipid accumulation in hepatocytes (HP:0006561) | 3.21895123 |
14 | Pancreatic cysts (HP:0001737) | 3.21756329 |
15 | Pancreatic fibrosis (HP:0100732) | 3.05310687 |
16 | Nephronophthisis (HP:0000090) | 2.99433116 |
17 | Cerebral edema (HP:0002181) | 2.78641590 |
18 | Colon cancer (HP:0003003) | 2.66539380 |
19 | Hepatocellular necrosis (HP:0001404) | 2.63966069 |
20 | Congenital stationary night blindness (HP:0007642) | 2.62585904 |
21 | Type II lissencephaly (HP:0007260) | 2.54059572 |
22 | Increased serum lactate (HP:0002151) | 2.50325330 |
23 | Renal Fanconi syndrome (HP:0001994) | 2.47992205 |
24 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.45520109 |
25 | Methylmalonic aciduria (HP:0012120) | 2.44032679 |
26 | Methylmalonic acidemia (HP:0002912) | 2.42468680 |
27 | Hypoplasia of the pons (HP:0012110) | 2.42026545 |
28 | Pendular nystagmus (HP:0012043) | 2.41369353 |
29 | Hyperglycinemia (HP:0002154) | 2.39840588 |
30 | Abnormality of chromosome stability (HP:0003220) | 2.39789249 |
31 | Abnormality of the pons (HP:0007361) | 2.37543644 |
32 | Medial flaring of the eyebrow (HP:0010747) | 2.36908620 |
33 | Abnormality of the renal medulla (HP:0100957) | 2.36098889 |
34 | Hepatic necrosis (HP:0002605) | 2.35829194 |
35 | Meckel diverticulum (HP:0002245) | 2.33936304 |
36 | Abnormality of the ileum (HP:0001549) | 2.32475622 |
37 | Optic disc pallor (HP:0000543) | 2.25605969 |
38 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.25030381 |
39 | Lactic acidosis (HP:0003128) | 2.18131550 |
40 | Increased intramyocellular lipid droplets (HP:0012240) | 2.14210711 |
41 | Reticulocytopenia (HP:0001896) | 2.13721824 |
42 | Birth length less than 3rd percentile (HP:0003561) | 2.12772588 |
43 | Aplastic anemia (HP:0001915) | 2.12650798 |
44 | Abolished electroretinogram (ERG) (HP:0000550) | 2.12512896 |
45 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.10335964 |
46 | Anencephaly (HP:0002323) | 2.09434019 |
47 | Absent thumb (HP:0009777) | 2.08246539 |
48 | Abnormality of alanine metabolism (HP:0010916) | 2.05381574 |
49 | Hyperalaninemia (HP:0003348) | 2.05381574 |
50 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.05381574 |
51 | Sclerocornea (HP:0000647) | 2.03181213 |
52 | Volvulus (HP:0002580) | 2.02999778 |
53 | Exertional dyspnea (HP:0002875) | 2.02594364 |
54 | Lethargy (HP:0001254) | 2.00182390 |
55 | Abnormality of DNA repair (HP:0003254) | 1.98674663 |
56 | Postaxial foot polydactyly (HP:0001830) | 1.95063462 |
57 | Leukodystrophy (HP:0002415) | 1.93745805 |
58 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.92672517 |
59 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.89860358 |
60 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.89257826 |
61 | Chromsome breakage (HP:0040012) | 1.88762148 |
62 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.88702648 |
63 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.88702648 |
64 | Abnormality of the renal cortex (HP:0011035) | 1.86178828 |
65 | Pancytopenia (HP:0001876) | 1.85489893 |
66 | Cerebral hypomyelination (HP:0006808) | 1.85220433 |
67 | Male pseudohermaphroditism (HP:0000037) | 1.84645925 |
68 | Ectopic kidney (HP:0000086) | 1.84102868 |
69 | Abnormality of serum amino acid levels (HP:0003112) | 1.84007627 |
70 | Focal motor seizures (HP:0011153) | 1.83910790 |
71 | Clubbing of toes (HP:0100760) | 1.83845044 |
72 | Small hand (HP:0200055) | 1.83290976 |
73 | Thyroid-stimulating hormone excess (HP:0002925) | 1.82991842 |
74 | Oligodactyly (HP:0012165) | 1.81493802 |
75 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.81155080 |
76 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.80920412 |
77 | Microvesicular hepatic steatosis (HP:0001414) | 1.80062524 |
78 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.79433637 |
79 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.78273778 |
80 | Respiratory failure (HP:0002878) | 1.78258939 |
81 | Abnormality of the preputium (HP:0100587) | 1.77831928 |
82 | Oligodactyly (hands) (HP:0001180) | 1.77482675 |
83 | Sloping forehead (HP:0000340) | 1.77314736 |
84 | Febrile seizures (HP:0002373) | 1.76420327 |
85 | Exercise intolerance (HP:0003546) | 1.75919633 |
86 | Congenital, generalized hypertrichosis (HP:0004540) | 1.75818393 |
87 | Gait imbalance (HP:0002141) | 1.74618901 |
88 | Abnormal number of incisors (HP:0011064) | 1.73622930 |
89 | Cystic liver disease (HP:0006706) | 1.73450852 |
90 | Atonic seizures (HP:0010819) | 1.73172893 |
91 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.72595401 |
92 | Congenital primary aphakia (HP:0007707) | 1.72181067 |
93 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.71499608 |
94 | Increased muscle lipid content (HP:0009058) | 1.70486769 |
95 | Abnormal hair whorl (HP:0010721) | 1.70368884 |
96 | Abnormality of renal resorption (HP:0011038) | 1.70232132 |
97 | Lissencephaly (HP:0001339) | 1.68565850 |
98 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.66959382 |
99 | Supernumerary spleens (HP:0009799) | 1.65846069 |
100 | Patellar aplasia (HP:0006443) | 1.65578853 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BMPR1B | 2.91973115 |
2 | STK16 | 2.58785723 |
3 | FRK | 2.57675302 |
4 | CDC7 | 2.55943027 |
5 | MAP4K2 | 2.45338009 |
6 | ZAK | 2.39153736 |
7 | VRK2 | 2.33639159 |
8 | WNK3 | 2.21278063 |
9 | PLK4 | 2.13571628 |
10 | MKNK2 | 2.07650689 |
11 | GRK1 | 2.03660375 |
12 | VRK1 | 2.02377996 |
13 | SRPK1 | 2.01534644 |
14 | WEE1 | 2.00113374 |
15 | BUB1 | 1.98726892 |
16 | ADRBK2 | 1.96340786 |
17 | WNK4 | 1.94418794 |
18 | PLK2 | 1.94167173 |
19 | INSRR | 1.94159968 |
20 | MST4 | 1.90013181 |
21 | TLK1 | 1.87882056 |
22 | TAOK3 | 1.87031223 |
23 | NUAK1 | 1.83753236 |
24 | CASK | 1.83384449 |
25 | TRIM28 | 1.65806290 |
26 | MAPK13 | 1.63366282 |
27 | BRSK2 | 1.55759512 |
28 | PLK3 | 1.52707164 |
29 | BCKDK | 1.31436027 |
30 | STK39 | 1.31364372 |
31 | PINK1 | 1.31195852 |
32 | TIE1 | 1.28573536 |
33 | MAP3K12 | 1.26415964 |
34 | DYRK2 | 1.25997146 |
35 | TNIK | 1.23598201 |
36 | TSSK6 | 1.20667802 |
37 | MKNK1 | 1.18620456 |
38 | PLK1 | 1.10955854 |
39 | TTK | 1.10430080 |
40 | GRK7 | 1.07284126 |
41 | OXSR1 | 1.04224934 |
42 | TXK | 1.01856267 |
43 | ACVR1B | 0.91641522 |
44 | NEK1 | 0.89838912 |
45 | PNCK | 0.89769509 |
46 | CSNK1G1 | 0.87759245 |
47 | TEC | 0.87089093 |
48 | AURKB | 0.83969048 |
49 | MARK1 | 0.81410332 |
50 | ATR | 0.79377657 |
51 | TAF1 | 0.77588990 |
52 | PAK3 | 0.75381111 |
53 | RPS6KA4 | 0.74952355 |
54 | CCNB1 | 0.72956342 |
55 | PRKCG | 0.71827353 |
56 | RPS6KA5 | 0.70150785 |
57 | EIF2AK1 | 0.69196205 |
58 | AURKA | 0.68028322 |
59 | BRSK1 | 0.65891264 |
60 | PDK2 | 0.63534340 |
61 | ERBB3 | 0.63331715 |
62 | PIK3CA | 0.63052835 |
63 | PRKCQ | 0.62837076 |
64 | ADRBK1 | 0.62725644 |
65 | BCR | 0.60499644 |
66 | MUSK | 0.57639454 |
67 | CSNK1G3 | 0.56743364 |
68 | TGFBR1 | 0.55071360 |
69 | CDK3 | 0.54358458 |
70 | CDK8 | 0.54095404 |
71 | GRK5 | 0.53039287 |
72 | PRKCE | 0.52595538 |
73 | CSNK1G2 | 0.51642699 |
74 | PBK | 0.51334739 |
75 | EIF2AK2 | 0.51282189 |
76 | PKN1 | 0.50411802 |
77 | MATK | 0.48854024 |
78 | EIF2AK3 | 0.48573463 |
79 | CAMK1 | 0.48403566 |
80 | NTRK3 | 0.48138807 |
81 | MINK1 | 0.48135008 |
82 | KDR | 0.47507692 |
83 | EPHA4 | 0.46823201 |
84 | CHEK2 | 0.46549144 |
85 | CSNK1A1 | 0.45633983 |
86 | NME1 | 0.45519360 |
87 | ATM | 0.45344036 |
88 | CSNK2A2 | 0.44455302 |
89 | ERBB2 | 0.43789176 |
90 | CAMK2A | 0.43598203 |
91 | MAP3K4 | 0.43286398 |
92 | CSNK1E | 0.42724658 |
93 | CSNK2A1 | 0.42163796 |
94 | CLK1 | 0.39824084 |
95 | IKBKB | 0.38898768 |
96 | PTK2B | 0.38743949 |
97 | ROCK1 | 0.38563456 |
98 | PRKACA | 0.37999726 |
99 | ITK | 0.36775458 |
100 | CSNK1A1L | 0.36029117 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.04476915 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.10702029 |
3 | Protein export_Homo sapiens_hsa03060 | 3.04640411 |
4 | Homologous recombination_Homo sapiens_hsa03440 | 2.71914997 |
5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.63363461 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.59654755 |
7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.21651035 |
8 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.21509791 |
9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.15137012 |
10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.14556101 |
11 | Ribosome_Homo sapiens_hsa03010 | 2.12232318 |
12 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.10118927 |
13 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.02935029 |
14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.95360451 |
15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.95236633 |
16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.80964247 |
17 | Mismatch repair_Homo sapiens_hsa03430 | 1.77112342 |
18 | DNA replication_Homo sapiens_hsa03030 | 1.70595276 |
19 | Phototransduction_Homo sapiens_hsa04744 | 1.67910486 |
20 | RNA degradation_Homo sapiens_hsa03018 | 1.64950375 |
21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.55433171 |
22 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.54439519 |
23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.52828775 |
24 | Spliceosome_Homo sapiens_hsa03040 | 1.51596980 |
25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.50680703 |
26 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.44995503 |
27 | Base excision repair_Homo sapiens_hsa03410 | 1.41364196 |
28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.40667418 |
29 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.38308941 |
30 | Asthma_Homo sapiens_hsa05310 | 1.35456639 |
31 | RNA transport_Homo sapiens_hsa03013 | 1.32331880 |
32 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.31547339 |
33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.31327268 |
34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.25092198 |
35 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.25066675 |
36 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.24595712 |
37 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.23158436 |
38 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.20554782 |
39 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.13238343 |
40 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.08882501 |
41 | Purine metabolism_Homo sapiens_hsa00230 | 1.08510524 |
42 | Nicotine addiction_Homo sapiens_hsa05033 | 1.07608276 |
43 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.07013946 |
44 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.06391685 |
45 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.06143367 |
46 | Allograft rejection_Homo sapiens_hsa05330 | 1.02778089 |
47 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.02289804 |
48 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.00308009 |
49 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.98302720 |
50 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.96773924 |
51 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.95442347 |
52 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.94759138 |
53 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.94090654 |
54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.93801999 |
55 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.92194718 |
56 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.90402103 |
57 | Olfactory transduction_Homo sapiens_hsa04740 | 0.88956172 |
58 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.87690254 |
59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.86469308 |
60 | Peroxisome_Homo sapiens_hsa04146 | 0.83016147 |
61 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.81182543 |
62 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.80599691 |
63 | Taste transduction_Homo sapiens_hsa04742 | 0.77938362 |
64 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.72063923 |
65 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.70488173 |
66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68751349 |
67 | Retinol metabolism_Homo sapiens_hsa00830 | 0.68684210 |
68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68086353 |
69 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.67548187 |
70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.67519329 |
71 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.66537383 |
72 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.65954268 |
73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65446812 |
74 | Cell cycle_Homo sapiens_hsa04110 | 0.61357243 |
75 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.58207096 |
76 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.58036706 |
77 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.56320663 |
78 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52598404 |
79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.52058701 |
80 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.51159755 |
81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48566654 |
82 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.48235878 |
83 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.47102611 |
84 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.46968498 |
85 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.46685901 |
86 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.44382013 |
87 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44153714 |
88 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.42766598 |
89 | ABC transporters_Homo sapiens_hsa02010 | 0.40742185 |
90 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.40079503 |
91 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.39584399 |
92 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.39053644 |
93 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.35003491 |
94 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.32684501 |
95 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.30914055 |
96 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.30712733 |
97 | Circadian rhythm_Homo sapiens_hsa04710 | 0.30260231 |
98 | Insulin secretion_Homo sapiens_hsa04911 | 0.29526890 |
99 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.29487978 |
100 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.27098042 |