HMGB1P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational termination (GO:0006449)9.90108543
2negative regulation of calcium ion-dependent exocytosis (GO:0045955)9.55209446
3adult feeding behavior (GO:0008343)9.32336360
4regulation of acrosome reaction (GO:0060046)8.10255037
5regulation of female receptivity (GO:0045924)7.94037330
6regulation of protein glycosylation (GO:0060049)7.66408709
7positive regulation of cAMP-mediated signaling (GO:0043950)7.37321007
8negative regulation of nitric oxide biosynthetic process (GO:0045019)7.18130955
9female mating behavior (GO:0060180)6.94941269
10sphingosine metabolic process (GO:0006670)6.90531299
11piRNA metabolic process (GO:0034587)6.62173961
12notochord development (GO:0030903)6.52358983
13diol metabolic process (GO:0034311)6.23150475
14thrombin receptor signaling pathway (GO:0070493)6.20291412
15sphingoid metabolic process (GO:0046519)6.00593035
16glycerol ether metabolic process (GO:0006662)5.81399529
17negative regulation of glycoprotein biosynthetic process (GO:0010561)5.66590475
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.52494679
19ether metabolic process (GO:0018904)5.36924874
20regulation of glutamate receptor signaling pathway (GO:1900449)5.25353502
21cellular response to ammonium ion (GO:0071242)5.24826418
22DNA replication-dependent nucleosome organization (GO:0034723)5.20543306
23DNA replication-dependent nucleosome assembly (GO:0006335)5.20543306
24ncRNA catabolic process (GO:0034661)5.19711460
25regulation of cAMP-mediated signaling (GO:0043949)4.77625476
26mRNA cleavage (GO:0006379)4.73479000
27signal complex assembly (GO:0007172)4.71364220
28glomerular visceral epithelial cell development (GO:0072015)4.59486507
29pyrimidine dimer repair (GO:0006290)4.37412646
30negative regulation of adenylate cyclase activity (GO:0007194)4.21809410
31negative regulation of glycoprotein metabolic process (GO:1903019)4.14434011
32cellular response to alkaloid (GO:0071312)4.04004862
33regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.03254815
34glomerular epithelial cell development (GO:0072310)4.01814863
35negative regulation of cyclase activity (GO:0031280)4.01441683
36negative regulation of cell-matrix adhesion (GO:0001953)3.93707044
37cell-cell junction maintenance (GO:0045217)3.82112744
38negative regulation of lyase activity (GO:0051350)3.78409015
39N-terminal protein amino acid acetylation (GO:0006474)3.73799535
40coenzyme catabolic process (GO:0009109)3.71307120
41cornea development in camera-type eye (GO:0061303)3.65412899
42fat-soluble vitamin catabolic process (GO:0042363)3.65281417
43vitamin catabolic process (GO:0009111)3.65281417
44regulation of translational elongation (GO:0006448)3.59375162
45glycosphingolipid metabolic process (GO:0006687)3.53451232
46negative regulation of exocytosis (GO:0045920)3.52633528
47dopamine receptor signaling pathway (GO:0007212)3.49352621
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.36220000
49wound healing, spreading of epidermal cells (GO:0035313)3.34761806
50indolalkylamine metabolic process (GO:0006586)3.34750427
51positive regulation of cardiac muscle cell differentiation (GO:2000727)3.32038133
52detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.29594277
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.27985742
54response to morphine (GO:0043278)3.27342547
55glomerular basement membrane development (GO:0032836)3.21343481
56multicellular organismal reproductive behavior (GO:0033057)3.17477240
57chemical homeostasis within a tissue (GO:0048875)3.17263855
58transmission of nerve impulse (GO:0019226)3.15823791
59protein-chromophore linkage (GO:0018298)3.14246010
60neuronal action potential (GO:0019228)3.14231623
61omega-hydroxylase P450 pathway (GO:0097267)3.13210885
62regulation of memory T cell differentiation (GO:0043380)3.11983063
63response to isoquinoline alkaloid (GO:0014072)3.11931703
64left/right axis specification (GO:0070986)3.08385390
65membrane depolarization during action potential (GO:0086010)3.04938408
66thyroid hormone generation (GO:0006590)3.02237378
67positive regulation of nitric oxide biosynthetic process (GO:0045429)3.00632006
68regulation of rhodopsin mediated signaling pathway (GO:0022400)2.97539319
69negative regulation of cAMP biosynthetic process (GO:0030818)2.95432819
70cell junction maintenance (GO:0034331)2.91440847
71negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.84106292
72DNA synthesis involved in DNA repair (GO:0000731)2.83402412
73regulation of odontogenesis (GO:0042481)2.82951613
74smooth muscle tissue development (GO:0048745)2.82650366
75positive regulation of fatty acid transport (GO:2000193)2.80741174
76thyroid hormone metabolic process (GO:0042403)2.80585534
77positive regulation of icosanoid secretion (GO:0032305)2.76934294
78response to caffeine (GO:0031000)2.76784526
79positive regulation of protein complex disassembly (GO:0043243)2.76169415
80relaxation of smooth muscle (GO:0044557)2.75625031
81glycolipid metabolic process (GO:0006664)2.75609483
82regulation of calcium ion-dependent exocytosis (GO:0017158)2.74404942
83sensory perception of pain (GO:0019233)2.72482125
84spermatid development (GO:0007286)2.72265450
85positive regulation of cholesterol efflux (GO:0010875)2.72207083
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71662861
87lung epithelial cell differentiation (GO:0060487)2.70097863
88negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.68220255
89negative regulation of nucleotide biosynthetic process (GO:0030809)2.68220255
90viral mRNA export from host cell nucleus (GO:0046784)2.67368310
91rhodopsin mediated signaling pathway (GO:0016056)2.66885907
92membrane lipid metabolic process (GO:0006643)2.63747462
93urate metabolic process (GO:0046415)2.58438385
94liposaccharide metabolic process (GO:1903509)2.56944753
95negative regulation of cytosolic calcium ion concentration (GO:0051481)15.2401206
96negative regulation of cAMP-mediated signaling (GO:0043951)12.9217530
97opioid receptor signaling pathway (GO:0038003)11.8105576
98ether lipid metabolic process (GO:0046485)10.3228270
99behavioral response to ethanol (GO:0048149)10.2811686
100adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)10.2575344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.32528960
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.89379752
3VDR_22108803_ChIP-Seq_LS180_Human3.48070254
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33825359
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse3.20873976
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.20873976
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11695778
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08994971
9RXR_22108803_ChIP-Seq_LS180_Human2.69900384
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54818381
11EGR1_19032775_ChIP-ChIP_M12_Human2.27189811
12TAF15_26573619_Chip-Seq_HEK293_Human2.26677663
13GBX2_23144817_ChIP-Seq_PC3_Human2.26624062
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05170359
15ZNF274_21170338_ChIP-Seq_K562_Hela2.04300354
16SOX2_19829295_ChIP-Seq_ESCs_Human1.99744829
17NANOG_19829295_ChIP-Seq_ESCs_Human1.99744829
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92652586
19HTT_18923047_ChIP-ChIP_STHdh_Human1.87784572
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86841498
21TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.80550683
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76695350
23CBP_20019798_ChIP-Seq_JUKART_Human1.76695350
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.73439643
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70942207
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68501473
27TCF4_23295773_ChIP-Seq_U87_Human1.66284546
28DROSHA_22980978_ChIP-Seq_HELA_Human1.65562489
29BCAT_22108803_ChIP-Seq_LS180_Human1.63427819
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61891113
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57217356
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57033895
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56241958
34CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54947105
35STAT3_23295773_ChIP-Seq_U87_Human1.50407676
36FLI1_21867929_ChIP-Seq_TH2_Mouse1.45976068
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.45804530
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.41412419
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39611589
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39070564
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36350786
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35827695
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34929107
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34636101
45NANOG_20526341_ChIP-Seq_ESCs_Human1.34481919
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30220548
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.29660084
48P300_19829295_ChIP-Seq_ESCs_Human1.29525329
49TP53_18474530_ChIP-ChIP_U2OS_Human1.27501249
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.26911697
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26525614
52FOXH1_21741376_ChIP-Seq_ESCs_Human1.26314217
53SCL_19346495_ChIP-Seq_HPC-7_Human1.26045855
54SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.24520612
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.24247446
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23972027
57CDX2_22108803_ChIP-Seq_LS180_Human1.21121258
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.17845970
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17083598
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.16357793
61IRF1_19129219_ChIP-ChIP_H3396_Human1.15786386
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.13943343
63RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13875299
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11822450
65CEBPB_22108803_ChIP-Seq_LS180_Human1.11745508
66FUS_26573619_Chip-Seq_HEK293_Human1.11673613
67TP53_22573176_ChIP-Seq_HFKS_Human1.11444592
68GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.11359350
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10912635
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.09926984
71IGF1R_20145208_ChIP-Seq_DFB_Human1.09752825
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09432772
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09083288
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07982058
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.06240288
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.06172137
77TCF4_22108803_ChIP-Seq_LS180_Human1.06078304
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05829959
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03938783
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03824364
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03689340
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03661811
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02396503
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01981579
85KDM2B_26808549_Chip-Seq_REH_Human1.00371681
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00102385
87AR_25329375_ChIP-Seq_VCAP_Human1.00016634
88SMAD4_21799915_ChIP-Seq_A2780_Human0.99800445
89GATA3_21867929_ChIP-Seq_TH1_Mouse0.99480833
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99092812
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96022289
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.96019084
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.94758659
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94471452
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94311380
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93697421
97ER_23166858_ChIP-Seq_MCF-7_Human0.93616585
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.92344234
99RAC3_21632823_ChIP-Seq_H3396_Human0.92333691
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91934128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo8.19730585
2MP0009278_abnormal_bone_marrow6.28849055
3MP0002876_abnormal_thyroid_physiology5.28961967
4MP0005360_urolithiasis4.30064587
5MP0001968_abnormal_touch/_nociception3.83062684
6MP0005503_abnormal_tendon_morphology3.76410191
7MP0003941_abnormal_skin_development3.03532018
8MP0000678_abnormal_parathyroid_gland3.03258264
9MP0000681_abnormal_thyroid_gland2.83724586
10MP0003880_abnormal_central_pattern2.45340811
11MP0009764_decreased_sensitivity_to2.41895882
12MP0001501_abnormal_sleep_pattern2.41360652
13MP0003879_abnormal_hair_cell2.37905487
14MP0005397_hematopoietic_system_phenotyp2.37329309
15MP0001545_abnormal_hematopoietic_system2.37329309
16MP0005646_abnormal_pituitary_gland2.28544964
17MP0006035_abnormal_mitochondrial_morpho2.26679360
18MP0003045_fibrosis2.26194181
19MP0001664_abnormal_digestion2.11921929
20MP0005551_abnormal_eye_electrophysiolog1.99457857
21MP0009333_abnormal_splenocyte_physiolog1.97699973
22MP0003136_yellow_coat_color1.92928507
23MP0002249_abnormal_larynx_morphology1.79501029
24MP0003183_abnormal_peptide_metabolism1.72518334
25MP0008057_abnormal_DNA_replication1.70352921
26MP0003191_abnormal_cellular_cholesterol1.70347618
27MP0003638_abnormal_response/metabolism_1.69703072
28MP0003633_abnormal_nervous_system1.61221292
29MP0004858_abnormal_nervous_system1.59560150
30MP0003195_calcinosis1.58405592
31MP0003646_muscle_fatigue1.58289540
32MP0003959_abnormal_lean_body1.44398430
33MP0003950_abnormal_plasma_membrane1.41532664
34MP0005645_abnormal_hypothalamus_physiol1.37457706
35MP0010234_abnormal_vibrissa_follicle1.36537947
36MP0002733_abnormal_thermal_nociception1.34029759
37MP0004130_abnormal_muscle_cell1.32225571
38MP0009046_muscle_twitch1.30321858
39MP0003567_abnormal_fetal_cardiomyocyte1.23676705
40MP0009745_abnormal_behavioral_response1.19025206
41MP0004782_abnormal_surfactant_physiolog1.16188814
42MP0002796_impaired_skin_barrier1.15195376
43MP0002971_abnormal_brown_adipose1.11638916
44MP0000230_abnormal_systemic_arterial1.11259531
45MP0009765_abnormal_xenobiotic_induced1.11210634
46MP0008775_abnormal_heart_ventricle1.10341345
47MP0002272_abnormal_nervous_system1.03092057
48MP0002168_other_aberrant_phenotype0.99578305
49MP0001881_abnormal_mammary_gland0.98515181
50MP0002163_abnormal_gland_morphology0.95923292
51MP0009384_cardiac_valve_regurgitation0.93289077
52MP0005670_abnormal_white_adipose0.89841079
53MP0001270_distended_abdomen0.87575394
54MP0004147_increased_porphyrin_level0.86699311
55MP0000049_abnormal_middle_ear0.84435742
56MP0003631_nervous_system_phenotype0.83666066
57MP0001486_abnormal_startle_reflex0.82022919
58MP0005334_abnormal_fat_pad0.81796870
59MP0001970_abnormal_pain_threshold0.78637846
60MP0002132_abnormal_respiratory_system0.77133979
61MP0000372_irregular_coat_pigmentation0.76364265
62MP0003937_abnormal_limbs/digits/tail_de0.75835770
63MP0002693_abnormal_pancreas_physiology0.75280621
64MP0002148_abnormal_hypersensitivity_rea0.73163915
65MP0006276_abnormal_autonomic_nervous0.68377206
66MP0000749_muscle_degeneration0.67188757
67MP0008872_abnormal_physiological_respon0.66494203
68MP0005167_abnormal_blood-brain_barrier0.66465908
69MP0001919_abnormal_reproductive_system0.66159292
70MP0010771_integument_phenotype0.65751699
71MP0005310_abnormal_salivary_gland0.63773185
72MP0001986_abnormal_taste_sensitivity0.59938883
73MP0009672_abnormal_birth_weight0.58843076
74MP0005195_abnormal_posterior_eye0.58795091
75MP0004085_abnormal_heartbeat0.56950516
76MP0008874_decreased_physiological_sensi0.56908502
77MP0005501_abnormal_skin_physiology0.56491783
78MP0002108_abnormal_muscle_morphology0.56355590
79MP0006054_spinal_hemorrhage0.56062671
80MP0000015_abnormal_ear_pigmentation0.55577298
81MP0002557_abnormal_social/conspecific_i0.55084604
82MP0000358_abnormal_cell_content/0.54067649
83MP0003938_abnormal_ear_development0.53927834
84MP0001851_eye_inflammation0.53712335
85MP0002229_neurodegeneration0.52946196
86MP0001963_abnormal_hearing_physiology0.52264012
87MP0002998_abnormal_bone_remodeling0.51232017
88MP0001485_abnormal_pinna_reflex0.51142523
89MP0003868_abnormal_feces_composition0.50619724
90MP0005395_other_phenotype0.49184668
91MP0004859_abnormal_synaptic_plasticity0.47906268
92MP0005452_abnormal_adipose_tissue0.47657153
93MP0005390_skeleton_phenotype0.47167854
94MP0010678_abnormal_skin_adnexa0.46898774
95MP0000685_abnormal_immune_system0.46809707
96MP0006072_abnormal_retinal_apoptosis0.45062657
97MP0003936_abnormal_reproductive_system0.44783896
98MP0001348_abnormal_lacrimal_gland0.44403172
99MP0001756_abnormal_urination0.44291125
100MP0003635_abnormal_synaptic_transmissio0.42857713

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.94604909
2Intestinal atresia (HP:0011100)6.73061638
3Pancreatic islet-cell hyperplasia (HP:0004510)5.94947437
4Abnormality of the aortic arch (HP:0012303)5.89422488
5Large for gestational age (HP:0001520)5.51472318
6Oligodontia (HP:0000677)5.50343681
7Broad alveolar ridges (HP:0000187)5.45800124
8Thickened helices (HP:0000391)5.29023488
9Mesangial abnormality (HP:0001966)5.08004933
10Poor head control (HP:0002421)4.55486996
11Gaze-evoked nystagmus (HP:0000640)4.39407627
12Congenital ichthyosiform erythroderma (HP:0007431)4.34084388
13Focal motor seizures (HP:0011153)4.27852307
14Agitation (HP:0000713)4.26304213
15Abnormality of endocrine pancreas physiology (HP:0012093)3.88954646
16Abnormality of the pancreatic islet cells (HP:0006476)3.88954646
17Tubular atrophy (HP:0000092)3.78137068
18Abnormality of the ileum (HP:0001549)3.69847073
19Myositis (HP:0100614)3.41726142
20Hypoproteinemia (HP:0003075)3.41024911
21Cerebellar dysplasia (HP:0007033)3.36718972
22Gastrointestinal atresia (HP:0002589)3.33435741
23Large eyes (HP:0001090)3.23125586
24Type II lissencephaly (HP:0007260)3.22553839
25Tented upper lip vermilion (HP:0010804)3.22272588
26Orchitis (HP:0100796)3.19553022
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18419827
28Neonatal respiratory distress (HP:0002643)2.99949964
29Hyperthyroidism (HP:0000836)2.85970234
30Hyperpituitarism (HP:0010514)2.84233010
31Focal seizures (HP:0007359)2.77480226
32Congenital stationary night blindness (HP:0007642)2.77201982
33Chromsome breakage (HP:0040012)2.75257149
34Optic nerve hypoplasia (HP:0000609)2.73080140
35Long nose (HP:0003189)2.70651626
36Severe visual impairment (HP:0001141)2.68637168
37Nephroblastoma (Wilms tumor) (HP:0002667)2.68301284
38Abnormality of the alveolar ridges (HP:0006477)2.66479568
39Poor speech (HP:0002465)2.65663267
40Progressive inability to walk (HP:0002505)2.65513757
41Broad-based gait (HP:0002136)2.65199522
42Goiter (HP:0000853)2.56717206
43Embryonal renal neoplasm (HP:0011794)2.53908025
44Abnormality of macular pigmentation (HP:0008002)2.53586464
45Central scotoma (HP:0000603)2.38824774
46Dialeptic seizures (HP:0011146)2.37995350
47Attenuation of retinal blood vessels (HP:0007843)2.37558446
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37516453
49Nonprogressive disorder (HP:0003680)2.32240522
50Lissencephaly (HP:0001339)2.31158366
51Ectropion (HP:0000656)2.30449699
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23442032
53Hypoplasia of the brainstem (HP:0002365)2.23442032
54Abnormality of the vitreous humor (HP:0004327)2.21821773
55Restlessness (HP:0000711)2.16239301
56Dysdiadochokinesis (HP:0002075)2.16161281
57Elevated erythrocyte sedimentation rate (HP:0003565)2.08780697
58Generalized tonic-clonic seizures (HP:0002069)2.08078215
59Keratoconjunctivitis (HP:0001096)2.07177000
60Keratoconjunctivitis sicca (HP:0001097)2.07048122
61Abnormality of proline metabolism (HP:0010907)2.05007748
62Hydroxyprolinuria (HP:0003080)2.05007748
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04688564
64Hypohidrosis (HP:0000966)2.03851883
65Pigmentary retinal degeneration (HP:0001146)2.03161634
66Impulsivity (HP:0100710)2.02596868
673-Methylglutaconic aciduria (HP:0003535)2.01654495
68Scotoma (HP:0000575)2.01568338
69Increased corneal curvature (HP:0100692)2.01531674
70Keratoconus (HP:0000563)2.01531674
71Amelogenesis imperfecta (HP:0000705)2.01047436
72Thyroid-stimulating hormone excess (HP:0002925)14.1361771
73Muscular dystrophy (HP:0003560)1.93364819
74Non-midline cleft lip (HP:0100335)1.92294945
75Abnormality of nail color (HP:0100643)1.91398168
76High anterior hairline (HP:0009890)1.91190129
77Keratitis (HP:0000491)1.91053501
78Retrobulbar optic neuritis (HP:0100654)1.90379827
79Optic neuritis (HP:0100653)1.90379827
80Pili torti (HP:0003777)1.89717821
81Concave nail (HP:0001598)1.89504232
82Autoimmune hemolytic anemia (HP:0001890)1.89232704
83Hypoplasia of the pons (HP:0012110)1.87576234
84Striae distensae (HP:0001065)1.84732922
85Hypercortisolism (HP:0001578)1.84572985
86Hyperventilation (HP:0002883)1.82591550
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81984130
88Ileus (HP:0002595)1.80754951
89Conical tooth (HP:0000698)1.80050299
90Hamartoma (HP:0010566)1.79891935
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.79750846
92Pendular nystagmus (HP:0012043)1.77380895
93Choroideremia (HP:0001139)1.77224519
94Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.76816994
95Abnormal rod and cone electroretinograms (HP:0008323)1.74745520
96Peritonitis (HP:0002586)1.74678523
97Poikiloderma (HP:0001029)1.74206662
98Testicular neoplasm (HP:0010788)1.74100607
99Abnormal hair laboratory examination (HP:0003328)1.73857208
100Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73846205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.87841917
2ERN14.84595215
3PINK13.86650229
4IRAK33.45026797
5ADRBK12.82877604
6ACVR1B2.23244155
7ADRBK210.7269469
8IRAK11.87943288
9PRKCG1.86363018
10TYRO31.86202307
11PNCK1.85385848
12TGFBR11.71211686
13PRKCE1.63693979
14BMPR1B1.48411857
15DYRK31.42279493
16CLK11.37147796
17GRK11.36593625
18MAPK111.36450446
19RIPK11.29316722
20PLK21.15405257
21NEK91.12181555
22KIT0.89840878
23CAMK2A0.87630826
24PRKCI0.83312318
25ERBB20.83213608
26CAMK1G0.77252307
27FLT30.77237105
28STK380.74584351
29MKNK10.69615588
30STK30.64690816
31BRSK10.58621521
32GRK70.56177712
33TAOK30.55519829
34STK390.52073206
35MKNK20.51562981
36OXSR10.49983135
37PRKCB0.46800779
38TXK0.45331068
39NEK20.45048182
40MAPKAPK50.44152838
41PIK3CG0.41859768
42CAMK10.41841681
43PTK2B0.39705109
44SGK10.38599286
45CDK120.37842488
46CSF1R0.37623496
47PRKCA0.37284075
48PRKCH0.36947147
49MAPK10.36824785
50AKT10.36131737
51STK38L0.35919982
52GRK50.34992394
53MELK0.32742220
54RPS6KA30.32349183
55CSNK2A20.31364946
56CAMK40.31138995
57ABL10.30499401
58DAPK20.30353875
59MAPK30.30139036
60STK100.29692429
61PKN20.29560155
62WEE10.29288623
63CSNK1E0.29157267
64PRKACG0.29014209
65WNK30.27639319
66CSNK1A10.26518575
67DYRK1A0.24823248
68FGFR20.23228438
69PRKACA0.21086389
70MST40.19958275
71GSK3B0.19925554
72MAP3K100.19465009
73CSNK2A10.19021738
74MAP2K10.18665193
75ZAK0.18133796
76NTRK20.17175521
77MAP2K20.16387952
78ATM0.16270753
79TEC0.16088799
80CDC42BPA0.15868771
81WNK40.15158770
82AURKB0.14584204
83PDK10.13783161
84ATR0.13254785
85TGFBR20.13139960
86IKBKB0.11730395
87TIE10.11393218
88CSNK1A1L0.11009048
89OBSCN0.09940281
90NME20.09907616
91MAPK100.09898178
92CDK10.09665892
93BRAF0.09576471
94MAPK140.09348174
95PRKDC0.09127018
96MAPK80.09013615
97CDK20.08897136
98EIF2AK20.08372349
99MOS0.07323980
100PRKAA10.07175538

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.86272436
2Olfactory transduction_Homo sapiens_hsa047403.49388552
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.42167359
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.96027517
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.85034779
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.82176592
7ABC transporters_Homo sapiens_hsa020102.78214924
8Tryptophan metabolism_Homo sapiens_hsa003802.75006754
9Phototransduction_Homo sapiens_hsa047442.67609152
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.64742260
11Morphine addiction_Homo sapiens_hsa050322.47001777
12Sphingolipid metabolism_Homo sapiens_hsa006002.32418249
13Sulfur relay system_Homo sapiens_hsa041222.29113089
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22206141
15Glycerolipid metabolism_Homo sapiens_hsa005612.21090337
16Pentose phosphate pathway_Homo sapiens_hsa000302.15463519
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.08285455
18Fanconi anemia pathway_Homo sapiens_hsa034601.86669318
19Butanoate metabolism_Homo sapiens_hsa006501.82690477
20Ovarian steroidogenesis_Homo sapiens_hsa049131.73258509
21Linoleic acid metabolism_Homo sapiens_hsa005911.67679357
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58819978
23Taste transduction_Homo sapiens_hsa047421.52931023
24Arachidonic acid metabolism_Homo sapiens_hsa005901.52311684
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41307312
26Complement and coagulation cascades_Homo sapiens_hsa046101.39395332
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38934870
28Starch and sucrose metabolism_Homo sapiens_hsa005001.34201012
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32638431
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29858602
31Salivary secretion_Homo sapiens_hsa049701.25329511
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24539649
33Retinol metabolism_Homo sapiens_hsa008301.24455154
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24201609
35Fatty acid degradation_Homo sapiens_hsa000711.22428410
36Caffeine metabolism_Homo sapiens_hsa002321.17034175
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11209906
38Nitrogen metabolism_Homo sapiens_hsa009101.09498720
39Calcium signaling pathway_Homo sapiens_hsa040201.07933796
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02623174
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02494567
42Mineral absorption_Homo sapiens_hsa049780.99236604
43Chemical carcinogenesis_Homo sapiens_hsa052040.97387552
44Histidine metabolism_Homo sapiens_hsa003400.94592019
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93823309
46Circadian entrainment_Homo sapiens_hsa047130.90120842
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.85427719
48Nicotine addiction_Homo sapiens_hsa050330.85341779
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84651045
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78547847
51Basal transcription factors_Homo sapiens_hsa030220.76644245
52Estrogen signaling pathway_Homo sapiens_hsa049150.75332146
53Homologous recombination_Homo sapiens_hsa034400.74666175
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73920835
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72432403
56Arginine and proline metabolism_Homo sapiens_hsa003300.71187399
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68794780
58Ether lipid metabolism_Homo sapiens_hsa005650.65879613
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.65850894
60One carbon pool by folate_Homo sapiens_hsa006700.64437725
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64376085
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.63729464
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.62913350
64Arginine biosynthesis_Homo sapiens_hsa002200.61372783
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61341196
66Glutamatergic synapse_Homo sapiens_hsa047240.61274311
67Legionellosis_Homo sapiens_hsa051340.61207639
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60714319
69ECM-receptor interaction_Homo sapiens_hsa045120.58503850
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.56674656
71Metabolic pathways_Homo sapiens_hsa011000.56034958
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.54329592
73Glutathione metabolism_Homo sapiens_hsa004800.49198048
74Serotonergic synapse_Homo sapiens_hsa047260.47301709
75beta-Alanine metabolism_Homo sapiens_hsa004100.42365653
76Purine metabolism_Homo sapiens_hsa002300.41979068
77Pancreatic secretion_Homo sapiens_hsa049720.40146257
78Long-term depression_Homo sapiens_hsa047300.38722213
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37322657
80RNA degradation_Homo sapiens_hsa030180.37124127
81MicroRNAs in cancer_Homo sapiens_hsa052060.36924176
82Fatty acid biosynthesis_Homo sapiens_hsa000610.35069130
83Hedgehog signaling pathway_Homo sapiens_hsa043400.34813052
84Peroxisome_Homo sapiens_hsa041460.34172922
85Lysosome_Homo sapiens_hsa041420.33310993
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31552575
87Graft-versus-host disease_Homo sapiens_hsa053320.30923631
88Oxytocin signaling pathway_Homo sapiens_hsa049210.30592227
89Basal cell carcinoma_Homo sapiens_hsa052170.28463375
90Renin secretion_Homo sapiens_hsa049240.26400205
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.25877040
92mRNA surveillance pathway_Homo sapiens_hsa030150.25212623
93GABAergic synapse_Homo sapiens_hsa047270.24779629
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24743671
95Insulin secretion_Homo sapiens_hsa049110.24692363
96cAMP signaling pathway_Homo sapiens_hsa040240.22336034
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.19782830
98Protein digestion and absorption_Homo sapiens_hsa049740.18512150
99Asthma_Homo sapiens_hsa053100.15765944
100Base excision repair_Homo sapiens_hsa034100.13840563

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