HMGB1P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1renal system development (GO:0072001)5.16026611
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.80498610
3ATP synthesis coupled proton transport (GO:0015986)4.80498610
4spliceosomal complex assembly (GO:0000245)4.79526346
5regulation of double-strand break repair via homologous recombination (GO:0010569)4.42479094
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.39089052
7DNA deamination (GO:0045006)4.35953935
8ribosomal small subunit assembly (GO:0000028)4.33666538
9multicellular organismal aging (GO:0010259)4.17711639
10kinetochore organization (GO:0051383)4.17459491
11protein neddylation (GO:0045116)4.15790992
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11081339
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87683876
14telomere maintenance via semi-conservative replication (GO:0032201)3.75137844
15cytidine deamination (GO:0009972)3.72828967
16cytidine metabolic process (GO:0046087)3.72828967
17cytidine catabolic process (GO:0006216)3.72828967
18nucleotide-excision repair, DNA gap filling (GO:0006297)3.72011224
19electron transport chain (GO:0022900)3.71009423
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.66831247
21base-excision repair, AP site formation (GO:0006285)3.63313538
22protein K6-linked ubiquitination (GO:0085020)3.61692581
23respiratory electron transport chain (GO:0022904)3.61649978
24cellular ketone body metabolic process (GO:0046950)3.60981467
25sequestering of actin monomers (GO:0042989)3.60305238
26chaperone-mediated protein transport (GO:0072321)3.59562598
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.54743187
28protein-cofactor linkage (GO:0018065)3.54217121
29protein complex biogenesis (GO:0070271)3.53024728
30kinetochore assembly (GO:0051382)3.48078359
31pseudouridine synthesis (GO:0001522)3.47348631
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46209590
33outer ear morphogenesis (GO:0042473)3.42138247
34chromatin remodeling at centromere (GO:0031055)3.38729782
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.35225814
36NADH dehydrogenase complex assembly (GO:0010257)3.35225814
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35225814
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33201217
39protein polyglutamylation (GO:0018095)3.30070386
40lactate metabolic process (GO:0006089)3.25088138
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24960001
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.24597620
43respiratory chain complex IV assembly (GO:0008535)3.24130210
44cotranslational protein targeting to membrane (GO:0006613)3.22981031
45DNA double-strand break processing (GO:0000729)3.22616272
46intracellular protein transmembrane transport (GO:0065002)3.20632516
47ketone body metabolic process (GO:1902224)3.18459797
48mitochondrial respiratory chain complex assembly (GO:0033108)3.18238901
49regulation of meiosis I (GO:0060631)3.17743964
50axoneme assembly (GO:0035082)3.16759710
51protein targeting to ER (GO:0045047)3.16597483
52preassembly of GPI anchor in ER membrane (GO:0016254)3.15954983
53telomere maintenance via recombination (GO:0000722)3.14671658
54CENP-A containing nucleosome assembly (GO:0034080)3.11897618
55mitotic G1 DNA damage checkpoint (GO:0031571)3.09495299
56telomere maintenance via telomere lengthening (GO:0010833)3.08170254
57mitotic recombination (GO:0006312)3.07201692
58negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.06975049
59protein localization to cilium (GO:0061512)3.06948662
60recombinational repair (GO:0000725)3.06853426
61cytochrome complex assembly (GO:0017004)3.03368667
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02591285
63negative regulation of telomere maintenance (GO:0032205)3.02384614
64ribosomal small subunit biogenesis (GO:0042274)3.00749738
65double-strand break repair via homologous recombination (GO:0000724)2.96762164
66ubiquinone biosynthetic process (GO:0006744)2.96733194
67pyrimidine nucleotide catabolic process (GO:0006244)2.95914298
68protein localization to endoplasmic reticulum (GO:0070972)2.94335462
69hypothalamus development (GO:0021854)2.92703036
70axonemal dynein complex assembly (GO:0070286)2.92291798
71pyrimidine ribonucleoside catabolic process (GO:0046133)2.91721838
72histone exchange (GO:0043486)2.90227886
73cell proliferation in forebrain (GO:0021846)2.89988244
74platelet dense granule organization (GO:0060155)2.85824884
75somatic hypermutation of immunoglobulin genes (GO:0016446)2.84724135
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84724135
77piRNA metabolic process (GO:0034587)2.84522390
78water-soluble vitamin biosynthetic process (GO:0042364)2.84296216
79proteasome assembly (GO:0043248)2.83198897
80centriole replication (GO:0007099)2.82189588
81meiotic chromosome segregation (GO:0045132)2.81466801
82DNA catabolic process, exonucleolytic (GO:0000738)2.80957756
83ATP biosynthetic process (GO:0006754)2.80751684
84viral transcription (GO:0019083)2.79351634
85ubiquinone metabolic process (GO:0006743)2.78877492
86G1 DNA damage checkpoint (GO:0044783)2.77861916
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76233806
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76233806
89mitotic G1/S transition checkpoint (GO:0044819)2.75486243
90translational termination (GO:0006415)2.72787883
91tongue development (GO:0043586)2.70184182
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67532327
93deoxyribonucleotide catabolic process (GO:0009264)2.65164384
94dentate gyrus development (GO:0021542)2.62610107
95transcription-coupled nucleotide-excision repair (GO:0006283)2.59454534
96purine nucleoside triphosphate biosynthetic process (GO:0009145)2.59255528
97regulation of DNA damage checkpoint (GO:2000001)2.58787912
98mitotic chromosome condensation (GO:0007076)2.57526970
99translational elongation (GO:0006414)2.57025458
100rRNA catabolic process (GO:0016075)2.55970830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.26340378
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.74748738
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54247427
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.13644786
5EZH2_22144423_ChIP-Seq_EOC_Human3.12422827
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93179677
7E2F7_22180533_ChIP-Seq_HELA_Human2.89667671
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.77837763
9IGF1R_20145208_ChIP-Seq_DFB_Human2.63354408
10ZNF274_21170338_ChIP-Seq_K562_Hela2.52479482
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45228872
12VDR_22108803_ChIP-Seq_LS180_Human2.38552982
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37727496
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.17916846
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16839650
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16630941
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.10525618
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06469832
19IRF1_19129219_ChIP-ChIP_H3396_Human2.00637512
20ELK1_19687146_ChIP-ChIP_HELA_Human1.86131594
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85992552
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85003940
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81132461
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72894010
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72756190
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69308690
27VDR_23849224_ChIP-Seq_CD4+_Human1.66034383
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63336165
29MYC_18940864_ChIP-ChIP_HL60_Human1.62246861
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55259176
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55097383
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51164481
33FUS_26573619_Chip-Seq_HEK293_Human1.45705201
34EWS_26573619_Chip-Seq_HEK293_Human1.43313385
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.42286670
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40058525
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39059379
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.39001593
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36376338
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35024696
41GABP_19822575_ChIP-Seq_HepG2_Human1.32931126
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.29399845
43P300_19829295_ChIP-Seq_ESCs_Human1.28275527
44AR_21572438_ChIP-Seq_LNCaP_Human1.26819440
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26604105
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24768276
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24182338
48FOXP3_21729870_ChIP-Seq_TREG_Human1.23794055
49SOX2_19829295_ChIP-Seq_ESCs_Human1.22868661
50NANOG_19829295_ChIP-Seq_ESCs_Human1.22868661
51GBX2_23144817_ChIP-Seq_PC3_Human1.22483037
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21909330
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21454879
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21174587
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20160009
56CBP_20019798_ChIP-Seq_JUKART_Human1.19724487
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19724487
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.19636998
59ER_23166858_ChIP-Seq_MCF-7_Human1.19543983
60AR_20517297_ChIP-Seq_VCAP_Human1.19307367
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18779739
62HTT_18923047_ChIP-ChIP_STHdh_Human1.18412674
63TP53_22573176_ChIP-Seq_HFKS_Human1.17577721
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.17042092
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.12635435
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10488849
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09056044
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07849059
69MYC_19829295_ChIP-Seq_ESCs_Human1.05911423
70ERA_21632823_ChIP-Seq_H3396_Human1.04817843
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03943666
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.03900891
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03900891
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01517594
75TTF2_22483619_ChIP-Seq_HELA_Human0.99839495
76NANOG_20526341_ChIP-Seq_ESCs_Human0.99517961
77SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99495303
78NCOR_22424771_ChIP-Seq_293T_Human0.99356684
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.98603923
80TAF2_19829295_ChIP-Seq_ESCs_Human0.97772686
81ERG_20517297_ChIP-Seq_VCAP_Human0.97718425
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97105003
83REST_21632747_ChIP-Seq_MESCs_Mouse0.96318987
84BCAT_22108803_ChIP-Seq_LS180_Human0.94555983
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94203690
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93804953
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.93659024
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92590394
89RBPJ_21746931_ChIP-Seq_IB4_Human0.90484370
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90427686
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90414091
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89608783
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89605508
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89502223
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89377180
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.88595293
97DCP1A_22483619_ChIP-Seq_HELA_Human0.88425335
98FOXM1_23109430_ChIP-Seq_U2OS_Human0.87739997
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86013023
100CTCF_20526341_ChIP-Seq_ESCs_Human0.85026862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.99444549
2MP0000566_synostosis3.69033207
3MP0008877_abnormal_DNA_methylation3.36431538
4MP0005394_taste/olfaction_phenotype2.59774580
5MP0005499_abnormal_olfactory_system2.59774580
6MP0008789_abnormal_olfactory_epithelium2.59393652
7MP0005646_abnormal_pituitary_gland2.40895653
8MP0004147_increased_porphyrin_level2.22242318
9MP0002163_abnormal_gland_morphology2.21700570
10MP0009046_muscle_twitch2.05903567
11MP0002938_white_spotting2.05758198
12MP0008872_abnormal_physiological_respon2.05357549
13MP0010030_abnormal_orbit_morphology2.01466861
14MP0008058_abnormal_DNA_repair1.96549016
15MP0002876_abnormal_thyroid_physiology1.91569250
16MP0005379_endocrine/exocrine_gland_phen1.80133725
17MP0003880_abnormal_central_pattern1.78940175
18MP0003787_abnormal_imprinting1.78774651
19MP0002653_abnormal_ependyma_morphology1.77342230
20MP0000372_irregular_coat_pigmentation1.76752916
21MP0009379_abnormal_foot_pigmentation1.75683466
22MP0010094_abnormal_chromosome_stability1.74034119
23MP0005551_abnormal_eye_electrophysiolog1.73568390
24MP0006276_abnormal_autonomic_nervous1.68415524
25MP0002095_abnormal_skin_pigmentation1.67704799
26MP0000049_abnormal_middle_ear1.67108976
27MP0001293_anophthalmia1.65285962
28MP0003693_abnormal_embryo_hatching1.64081135
29MP0002822_catalepsy1.62163846
30MP0002736_abnormal_nociception_after1.61389319
31MP0001968_abnormal_touch/_nociception1.60279284
32MP0003123_paternal_imprinting1.57919921
33MP0006072_abnormal_retinal_apoptosis1.56279749
34MP0003195_calcinosis1.54233810
35MP0008875_abnormal_xenobiotic_pharmacok1.52910005
36MP0005645_abnormal_hypothalamus_physiol1.44755546
37MP0005075_abnormal_melanosome_morpholog1.44501234
38MP0000631_abnormal_neuroendocrine_gland1.42844507
39MP0002249_abnormal_larynx_morphology1.42577594
40MP0003646_muscle_fatigue1.30685727
41MP0002233_abnormal_nose_morphology1.30359398
42MP0002272_abnormal_nervous_system1.30169660
43MP0002837_dystrophic_cardiac_calcinosis1.29016963
44MP0003121_genomic_imprinting1.27773403
45MP0008995_early_reproductive_senescence1.25089264
46MP0001984_abnormal_olfaction1.25085417
47MP0003011_delayed_dark_adaptation1.22665113
48MP0009745_abnormal_behavioral_response1.21454751
49MP0001348_abnormal_lacrimal_gland1.19919900
50MP0002909_abnormal_adrenal_gland1.19894167
51MP0000015_abnormal_ear_pigmentation1.15014863
52MP0001905_abnormal_dopamine_level1.14738454
53MP0004142_abnormal_muscle_tone1.14038504
54MP0001485_abnormal_pinna_reflex1.13282667
55MP0005174_abnormal_tail_pigmentation1.09041629
56MP0005084_abnormal_gallbladder_morpholo1.07747711
57MP0001188_hyperpigmentation1.04203680
58MP0005187_abnormal_penis_morphology1.03061419
59MP0005195_abnormal_posterior_eye0.99287292
60MP0003938_abnormal_ear_development0.99097419
61MP0006036_abnormal_mitochondrial_physio0.98355816
62MP0002102_abnormal_ear_morphology0.97167891
63MP0004145_abnormal_muscle_electrophysio0.96279350
64MP0005636_abnormal_mineral_homeostasis0.95459167
65MP0005253_abnormal_eye_physiology0.95438312
66MP0003567_abnormal_fetal_cardiomyocyte0.95147889
67MP0000778_abnormal_nervous_system0.94669071
68MP0002277_abnormal_respiratory_mucosa0.94200356
69MP0000026_abnormal_inner_ear0.91923195
70MP0002638_abnormal_pupillary_reflex0.89698508
71MP0003937_abnormal_limbs/digits/tail_de0.89400111
72MP0010307_abnormal_tumor_latency0.88742451
73MP0002557_abnormal_social/conspecific_i0.88098727
74MP0001929_abnormal_gametogenesis0.87685455
75MP0001765_abnormal_ion_homeostasis0.86914594
76MP0003136_yellow_coat_color0.86789933
77MP0003936_abnormal_reproductive_system0.86070203
78MP0005408_hypopigmentation0.85486951
79MP0003786_premature_aging0.85447200
80MP0003122_maternal_imprinting0.84009960
81MP0000579_abnormal_nail_morphology0.83022963
82MP0002210_abnormal_sex_determination0.82655173
83MP0005410_abnormal_fertilization0.82595922
84MP0003315_abnormal_perineum_morphology0.81179466
85MP0002138_abnormal_hepatobiliary_system0.80874066
86MP0001970_abnormal_pain_threshold0.79006433
87MP0003186_abnormal_redox_activity0.76710950
88MP0002572_abnormal_emotion/affect_behav0.76225652
89MP0002733_abnormal_thermal_nociception0.75794741
90MP0005671_abnormal_response_to0.75468848
91MP0000653_abnormal_sex_gland0.74567429
92MP0004043_abnormal_pH_regulation0.74476109
93MP0002752_abnormal_somatic_nervous0.73256942
94MP0002229_neurodegeneration0.73218358
95MP0005389_reproductive_system_phenotype0.73176227
96MP0009053_abnormal_anal_canal0.73174377
97MP0002111_abnormal_tail_morphology0.72522372
98MP0000955_abnormal_spinal_cord0.71877050
99MP0004381_abnormal_hair_follicle0.71089665
100MP0000613_abnormal_salivary_gland0.70895380

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.80516202
2Chromsome breakage (HP:0040012)5.43071082
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.80423341
4Birth length less than 3rd percentile (HP:0003561)4.80255653
5Reticulocytopenia (HP:0001896)4.58431721
6Cystic liver disease (HP:0006706)3.79634274
7Acute necrotizing encephalopathy (HP:0006965)3.54269828
8Molar tooth sign on MRI (HP:0002419)3.52472624
9Abnormality of midbrain morphology (HP:0002418)3.52472624
10Abnormality of cochlea (HP:0000375)3.21569206
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.21423290
12Breast hypoplasia (HP:0003187)3.21233137
13Abnormal mitochondria in muscle tissue (HP:0008316)3.08766159
14Progressive cerebellar ataxia (HP:0002073)3.04417709
15Abnormality of the renal collecting system (HP:0004742)3.04312376
16Acute encephalopathy (HP:0006846)3.03147192
17Mitochondrial inheritance (HP:0001427)2.98784819
18Duplicated collecting system (HP:0000081)2.95615638
19Congenital stationary night blindness (HP:0007642)2.92249381
20Pancreatic cysts (HP:0001737)2.89106928
21Pancreatic fibrosis (HP:0100732)2.88450032
22True hermaphroditism (HP:0010459)2.79877677
23Progressive macrocephaly (HP:0004481)2.77382508
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75415382
25Rib fusion (HP:0000902)2.72896761
26Oligodactyly (HP:0012165)2.71320945
27Abnormality of the ileum (HP:0001549)2.66480548
28Small hand (HP:0200055)2.66085892
29Meckel diverticulum (HP:0002245)2.62591351
30Triphalangeal thumb (HP:0001199)2.56491876
31Hypoplastic labia majora (HP:0000059)2.52598378
32Prostate neoplasm (HP:0100787)2.51740673
33Increased CSF lactate (HP:0002490)2.51736069
34Abnormality of chromosome stability (HP:0003220)2.46789101
35Ectopic kidney (HP:0000086)2.46632519
36Back pain (HP:0003418)2.43907930
37Hepatocellular necrosis (HP:0001404)2.42805454
38Morphological abnormality of the inner ear (HP:0011390)2.40227818
39Clubbing of toes (HP:0100760)2.39233916
40Absent thumb (HP:0009777)2.38353653
413-Methylglutaconic aciduria (HP:0003535)2.35709435
42Abnormality of the carotid arteries (HP:0005344)2.34198596
43Limb dystonia (HP:0002451)2.31571067
44Colon cancer (HP:0003003)2.27612190
45Abnormality of the labia majora (HP:0012881)2.25986277
46Sclerocornea (HP:0000647)2.19573015
47Hypoplastic female external genitalia (HP:0012815)2.19070931
48Optic disc pallor (HP:0000543)2.18378947
49Hepatic necrosis (HP:0002605)2.17773523
50Bile duct proliferation (HP:0001408)2.17237190
51Abnormal biliary tract physiology (HP:0012439)2.17237190
52Cerebral edema (HP:0002181)2.16331991
53Hemiparesis (HP:0001269)2.14355780
54Horseshoe kidney (HP:0000085)2.12865179
55Febrile seizures (HP:0002373)2.12613228
56Anophthalmia (HP:0000528)2.12531016
57Nephronophthisis (HP:0000090)2.11404437
58Pancytopenia (HP:0001876)2.08557922
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.07431351
60Optic nerve coloboma (HP:0000588)2.07102585
61Duodenal stenosis (HP:0100867)2.05240100
62Small intestinal stenosis (HP:0012848)2.05240100
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.04315191
64Abnormality of the diencephalon (HP:0010662)2.03689357
65Abnormality of the preputium (HP:0100587)2.02919039
66Constricted visual fields (HP:0001133)2.01723617
67Oligodactyly (hands) (HP:0001180)2.01186730
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00507315
69Pendular nystagmus (HP:0012043)2.00213800
70Myokymia (HP:0002411)1.99440955
71Aplasia/Hypoplasia of the patella (HP:0006498)1.99081789
72Patellar aplasia (HP:0006443)1.98075694
73Shawl scrotum (HP:0000049)1.97140328
74Aplastic anemia (HP:0001915)1.96219747
75Rhabdomyosarcoma (HP:0002859)1.93279989
76Bifid tongue (HP:0010297)1.92748525
77Optic nerve hypoplasia (HP:0000609)1.88515239
78Cutaneous finger syndactyly (HP:0010554)1.87716990
79Absent radius (HP:0003974)1.87585202
80Microretrognathia (HP:0000308)1.87542917
81Hyperglycinemia (HP:0002154)1.87502505
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85573012
83Abnormality of the duodenum (HP:0002246)1.82990368
84Renal Fanconi syndrome (HP:0001994)1.82563778
85Anencephaly (HP:0002323)1.80353402
86Esophageal atresia (HP:0002032)1.80305561
87Postaxial foot polydactyly (HP:0001830)1.79364382
88Labial hypoplasia (HP:0000066)1.79015178
89Absent forearm bone (HP:0003953)1.78743133
90Aplasia involving forearm bones (HP:0009822)1.78743133
91Supernumerary spleens (HP:0009799)1.78443159
92Facial hemangioma (HP:0000329)1.77251574
93Lipid accumulation in hepatocytes (HP:0006561)1.76368831
94Hypomagnesemia (HP:0002917)1.75603123
95Duplication of thumb phalanx (HP:0009942)1.75094814
96Abnormality of the aortic arch (HP:0012303)1.74663111
97Sloping forehead (HP:0000340)1.74022884
98Attenuation of retinal blood vessels (HP:0007843)1.73624370
99Elevated erythrocyte sedimentation rate (HP:0003565)1.73397856
100Hemivertebrae (HP:0002937)1.73335053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.37200592
2GRK13.27148793
3BRSK23.26140897
4LIMK12.79607631
5WNK32.71179697
6WNK42.69970735
7VRK22.34720508
8NUAK12.30632639
9WEE12.30068251
10BRSK12.23994547
11NEK12.22674657
12FRK2.22567226
13DYRK22.07159149
14PLK42.06645705
15TESK22.00495021
16STK161.95245799
17ZAK1.82513243
18CDC71.55548241
19AKT31.52083268
20EPHB21.47465219
21KSR11.40389450
22PLK31.37333221
23BUB11.35980095
24VRK11.35326312
25KDR1.32250851
26MAP4K21.23904334
27PLK11.20675556
28MAP3K41.20663895
29TLK11.17803901
30SGK21.16816190
31MAPK131.13387003
32ATR1.13307189
33SRPK11.06349329
34TNIK1.04435384
35MINK11.03300175
36TIE11.01006333
37EIF2AK21.00795336
38BMPR20.94844738
39SGK4940.94260762
40SGK2230.94260762
41RAF10.93558842
42MARK10.92265154
43PRKCI0.91577815
44EIF2AK10.90604044
45PLK20.90248858
46PAK60.89599404
47PAK30.88731075
48CCNB10.85370326
49MUSK0.84035673
50PRKCG0.83668029
51PINK10.81264661
52BCKDK0.80162369
53PNCK0.77307886
54TXK0.75788485
55STK390.73956948
56TAF10.72405925
57BMPR1B0.68582171
58INSRR0.66850613
59GRK50.66013394
60AURKB0.64804216
61OXSR10.63946800
62TESK10.63426357
63KSR20.63124312
64TAOK30.62628898
65DAPK10.61370861
66MARK30.58115952
67SGK30.57691569
68CHEK20.56997570
69ATM0.56923702
70AURKA0.56613090
71CSNK1G20.56031167
72CSNK1G30.55979721
73PRKD30.54186878
74AKT20.53799880
75CSNK1G10.52329805
76DYRK1A0.52055570
77LRRK20.51956878
78PHKG10.51596168
79PHKG20.51596168
80CASK0.50333942
81IKBKE0.49867351
82STK40.49317812
83BRAF0.48988002
84CSF1R0.47730001
85SGK10.45027951
86TEC0.42672700
87CSNK2A10.42191227
88PDK20.41884165
89MAP3K110.41393832
90TTK0.39941029
91DYRK30.39112669
92ADRBK10.38766425
93ERBB20.37553537
94NTRK20.35664823
95CAMK2A0.35517990
96IKBKB0.33542570
97EIF2AK30.33456212
98CSNK2A20.32756465
99PAK10.32051335
100PIK3CA0.32031589

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.02174583
2Homologous recombination_Homo sapiens_hsa034404.04081252
3Mismatch repair_Homo sapiens_hsa034303.68607577
4Oxidative phosphorylation_Homo sapiens_hsa001903.26558998
5DNA replication_Homo sapiens_hsa030303.00912127
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92042176
7Ribosome_Homo sapiens_hsa030102.83572721
8Parkinsons disease_Homo sapiens_hsa050122.83121129
9Fanconi anemia pathway_Homo sapiens_hsa034602.68429609
10Proteasome_Homo sapiens_hsa030502.62248661
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31751615
12Phototransduction_Homo sapiens_hsa047442.15268264
13Huntingtons disease_Homo sapiens_hsa050161.97481581
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88271632
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77698682
16Alzheimers disease_Homo sapiens_hsa050101.69127857
17Nucleotide excision repair_Homo sapiens_hsa034201.68518037
18Butanoate metabolism_Homo sapiens_hsa006501.68300989
19Non-homologous end-joining_Homo sapiens_hsa034501.66463989
20RNA polymerase_Homo sapiens_hsa030201.63039591
21Cardiac muscle contraction_Homo sapiens_hsa042601.57928054
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55456307
23Sulfur relay system_Homo sapiens_hsa041221.52216556
24Primary immunodeficiency_Homo sapiens_hsa053401.51928433
25Propanoate metabolism_Homo sapiens_hsa006401.48922107
26Linoleic acid metabolism_Homo sapiens_hsa005911.47194694
27RNA degradation_Homo sapiens_hsa030181.36106071
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33333592
29Caffeine metabolism_Homo sapiens_hsa002321.27043255
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26723580
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24385048
32Basal transcription factors_Homo sapiens_hsa030221.18636508
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10016604
34Nitrogen metabolism_Homo sapiens_hsa009101.04668358
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04527943
36Ether lipid metabolism_Homo sapiens_hsa005651.04523513
37Pyrimidine metabolism_Homo sapiens_hsa002401.02573488
38Spliceosome_Homo sapiens_hsa030401.00236188
39Base excision repair_Homo sapiens_hsa034100.96899641
40Purine metabolism_Homo sapiens_hsa002300.95525617
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93737287
42Steroid biosynthesis_Homo sapiens_hsa001000.92914633
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90721368
44Peroxisome_Homo sapiens_hsa041460.86896845
45Sulfur metabolism_Homo sapiens_hsa009200.85884180
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85405092
47Tryptophan metabolism_Homo sapiens_hsa003800.83891203
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81096171
49Olfactory transduction_Homo sapiens_hsa047400.80895017
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.80158680
51Fat digestion and absorption_Homo sapiens_hsa049750.79633831
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78961833
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.75749689
54Retinol metabolism_Homo sapiens_hsa008300.74600106
55Chemical carcinogenesis_Homo sapiens_hsa052040.72800723
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71008768
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69042799
58Collecting duct acid secretion_Homo sapiens_hsa049660.68953667
59Pyruvate metabolism_Homo sapiens_hsa006200.67909604
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.65354062
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65105054
62beta-Alanine metabolism_Homo sapiens_hsa004100.62213255
63Basal cell carcinoma_Homo sapiens_hsa052170.60698638
64Hedgehog signaling pathway_Homo sapiens_hsa043400.60214003
65Morphine addiction_Homo sapiens_hsa050320.59721877
66RNA transport_Homo sapiens_hsa030130.59290715
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57641634
68Fatty acid degradation_Homo sapiens_hsa000710.56480401
69Metabolic pathways_Homo sapiens_hsa011000.54845407
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.54754717
71Selenocompound metabolism_Homo sapiens_hsa004500.54199415
72Arachidonic acid metabolism_Homo sapiens_hsa005900.53003197
73Nicotine addiction_Homo sapiens_hsa050330.49663898
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.47208711
75Insulin secretion_Homo sapiens_hsa049110.44183969
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42656644
77Cell cycle_Homo sapiens_hsa041100.41765170
78Taste transduction_Homo sapiens_hsa047420.41123211
79One carbon pool by folate_Homo sapiens_hsa006700.39985703
80Fatty acid metabolism_Homo sapiens_hsa012120.39898714
81Serotonergic synapse_Homo sapiens_hsa047260.37029001
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.32987515
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29823378
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28417872
85Circadian entrainment_Homo sapiens_hsa047130.26680328
86Vitamin B6 metabolism_Homo sapiens_hsa007500.26529958
87Graft-versus-host disease_Homo sapiens_hsa053320.24642749
88GABAergic synapse_Homo sapiens_hsa047270.20547247
89Starch and sucrose metabolism_Homo sapiens_hsa005000.20437357
90Antigen processing and presentation_Homo sapiens_hsa046120.20144172
91Ovarian steroidogenesis_Homo sapiens_hsa049130.18690574
92Fatty acid elongation_Homo sapiens_hsa000620.17182026
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16719674
94Salivary secretion_Homo sapiens_hsa049700.15948670
95Alcoholism_Homo sapiens_hsa050340.13621684
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12361294
97Hematopoietic cell lineage_Homo sapiens_hsa046400.11801668
98Oocyte meiosis_Homo sapiens_hsa041140.11515597
99Vitamin digestion and absorption_Homo sapiens_hsa049770.11260572
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11241571

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