ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	4.64971010
2	retinal ganglion cell axon guidance (GO:0031290)	4.50892723
3	somite development (GO:0061053)	4.47333680
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.23339726
5	ovulation cycle (GO:0042698)	4.03832214
6	chaperone-mediated protein transport (GO:0072321)	4.01586543
7	short-term memory (GO:0007614)	3.99825659
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.99414128
9	intraciliary transport (GO:0042073)	3.91890634
10	DNA deamination (GO:0045006)	3.90689897
11	protein-cofactor linkage (GO:0018065)	3.89940865
12	ATP synthesis coupled proton transport (GO:0015986)	3.87008564
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.87008564
14	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.80905639
15	proteasome assembly (GO:0043248)	3.80010627
16	ribosomal small subunit assembly (GO:0000028)	3.78419071
17	cellular ketone body metabolic process (GO:0046950)	3.55262467
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.52320565
19	rRNA modification (GO:0000154)	3.46041836
20	neurotransmitter-gated ion channel clustering (GO:0072578)	3.42908009
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.32787217
22	respiratory chain complex IV assembly (GO:0008535)	3.30499192
23	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.29316396
24	substrate-independent telencephalic tangential migration (GO:0021826)	3.29316396
25	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.25576823
26	maturation of 5.8S rRNA (GO:0000460)	3.25007643
27	axonemal dynein complex assembly (GO:0070286)	3.19651542
28	ribonucleoprotein complex disassembly (GO:0032988)	3.18991663
29	protein complex biogenesis (GO:0070271)	3.18040666
30	epithelial cilium movement (GO:0003351)	3.17502912
31	DNA strand renaturation (GO:0000733)	3.16707859
32	ketone body metabolic process (GO:1902224)	3.13991085
33	chromatin remodeling at centromere (GO:0031055)	3.13259044
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11467004
35	behavioral response to nicotine (GO:0035095)	3.11285092
36	tyrosine phosphorylation of STAT protein (GO:0007260)	3.11027343
37	inner mitochondrial membrane organization (GO:0007007)	3.07552625
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06568328
39	base-excision repair, AP site formation (GO:0006285)	3.04508908
40	cytochrome complex assembly (GO:0017004)	3.03212712
41	organelle disassembly (GO:1903008)	3.01780886
42	water-soluble vitamin biosynthetic process (GO:0042364)	3.01615805
43	rRNA methylation (GO:0031167)	3.00809104
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00014317
45	NADH dehydrogenase complex assembly (GO:0010257)	3.00014317
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00014317
47	microtubule depolymerization (GO:0007019)	2.98949488
48	neuron recognition (GO:0008038)	2.98075534
49	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.96611198
50	CENP-A containing nucleosome assembly (GO:0034080)	2.95920391
51	protein localization to cilium (GO:0061512)	2.95380150
52	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.94471120
53	transmission of nerve impulse (GO:0019226)	2.94456886
54	regulation of cilium movement (GO:0003352)	2.94191212
55	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.92999329
56	replication fork processing (GO:0031297)	2.92903006
57	maturation of SSU-rRNA (GO:0030490)	2.91987168
58	positive regulation of protein deacetylation (GO:0090312)	2.91818509
59	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87831259
60	pyrimidine nucleotide catabolic process (GO:0006244)	2.85338121
61	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.84814382
62	rRNA catabolic process (GO:0016075)	2.82615039
63	axoneme assembly (GO:0035082)	2.78277219
64	respiratory electron transport chain (GO:0022904)	2.78156457
65	regulation of action potential (GO:0098900)	2.77071744
66	platelet dense granule organization (GO:0060155)	2.76642910
67	electron transport chain (GO:0022900)	2.75567564
68	protein localization to synapse (GO:0035418)	2.74975544
69	cardiovascular system development (GO:0072358)	2.73346537
70	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.73256785
71	cilium movement (GO:0003341)	2.68732713
72	forebrain neuron development (GO:0021884)	2.68366897
73	negative regulation of telomere maintenance (GO:0032205)	2.68205744
74	cilium or flagellum-dependent cell motility (GO:0001539)	2.67751594
75	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.66205762
76	cell proliferation in forebrain (GO:0021846)	2.65051744
77	translational termination (GO:0006415)	2.64403873
78	kinetochore organization (GO:0051383)	2.63003819
79	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.62405945
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.61970690
81	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.61970690
82	cell wall macromolecule catabolic process (GO:0016998)	2.59167202
83	viral transcription (GO:0019083)	2.58221408
84	regulation of chronic inflammatory response (GO:0002676)	2.58086718
85	histone exchange (GO:0043486)	2.57502538
86	centriole replication (GO:0007099)	2.54889219
87	L-serine metabolic process (GO:0006563)	2.54319120
88	regulation of telomere maintenance (GO:0032204)	2.54002599
89	gamma-aminobutyric acid transport (GO:0015812)	2.52773772
90	ATP biosynthetic process (GO:0006754)	2.52597040
91	ribosomal small subunit biogenesis (GO:0042274)	2.50591651
92	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.49904252
93	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.49904252
94	cellular biogenic amine catabolic process (GO:0042402)	2.49542945
95	amine catabolic process (GO:0009310)	2.49542945
96	DNA double-strand break processing (GO:0000729)	2.48760583
97	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.48334458
98	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.47502740
99	positive regulation of action potential (GO:0045760)	2.46534372
100	regulation of microtubule-based movement (GO:0060632)	2.45975491

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.51319635
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.28920168
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.66589789
4	VDR_22108803_ChIP-Seq_LS180_Human	3.60787245
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.10250949
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.07145919
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.92795908
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.82387953
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.69576424
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56585250
11	FUS_26573619_Chip-Seq_HEK293_Human	2.36194545
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.33537564
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16330663
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13926035
15	EWS_26573619_Chip-Seq_HEK293_Human	2.12069166
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.08879648
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.03956448
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96663198
19	P300_19829295_ChIP-Seq_ESCs_Human	1.87507329
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86734158
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84722449
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81335379
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.72910392
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71910447
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67779796
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67282864
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.58768429
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.58201941
29	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.57666123
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.57129556
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.54207108
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53543381
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50394354
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.50078950
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.49635734
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49083152
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.45567078
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39922667
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.38082098
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37653211
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37653211
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37645415
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36967233
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36937818
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36867458
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.36356125
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36356125
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32879754
49	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.31112986
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26774679
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26774679
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24001315
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23725588
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.21859330
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21340275
56	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19932618
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18767509
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18195101
59	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17552923
60	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16466148
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15621734
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14281232
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12929957
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11298266
65	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10712055
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10452826
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09622388
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09128850
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08306081
70	STAT3_23295773_ChIP-Seq_U87_Human	1.07762151
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04765908
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04759487
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04112796
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03938359
75	TCF4_23295773_ChIP-Seq_U87_Human	1.03768582
76	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02237356
77	TTF2_22483619_ChIP-Seq_HELA_Human	1.01850416
78	ERG_20517297_ChIP-Seq_VCAP_Human	1.01759945
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.01076450
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00638393
81	JUN_21703547_ChIP-Seq_K562_Human	0.99740556
82	NCOR_22424771_ChIP-Seq_293T_Human	0.99185110
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98773643
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98497786
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98267328
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98119590
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98090125
88	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97628394
89	TAF15_26573619_Chip-Seq_HEK293_Human	0.97108599
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.96413119
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96392943
92	AR_25329375_ChIP-Seq_VCAP_Human	0.94375375
93	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.94351744
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94224870
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91322077
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90688767
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.90246508
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.89359000
99	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.89079939
100	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.88972779

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.51680508
2	MP0008877_abnormal_DNA_methylation	3.28219279
3	MP0005645_abnormal_hypothalamus_physiol	3.16543800
4	MP0009379_abnormal_foot_pigmentation	2.82106469
5	MP0003315_abnormal_perineum_morphology	2.75645032
6	MP0002736_abnormal_nociception_after	2.54345038
7	MP0003122_maternal_imprinting	2.39311707
8	MP0003787_abnormal_imprinting	2.35345025
9	MP0000516_abnormal_urinary_system	2.32520015
10	MP0005367_renal/urinary_system_phenotyp	2.32520015
11	MP0005646_abnormal_pituitary_gland	2.09387048
12	MP0004142_abnormal_muscle_tone	2.08772834
13	MP0001968_abnormal_touch/_nociception	2.03218465
14	MP0003195_calcinosis	1.87991980
15	MP0009046_muscle_twitch	1.85624262
16	MP0005187_abnormal_penis_morphology	1.81785199
17	MP0003121_genomic_imprinting	1.78192028
18	MP0002272_abnormal_nervous_system	1.76437859
19	MP0003880_abnormal_central_pattern	1.72563653
20	MP0002653_abnormal_ependyma_morphology	1.70847062
21	MP0001485_abnormal_pinna_reflex	1.67974874
22	MP0002102_abnormal_ear_morphology	1.67019763
23	MP0008875_abnormal_xenobiotic_pharmacok	1.64713034
24	MP0003646_muscle_fatigue	1.64073327
25	MP0008995_early_reproductive_senescence	1.62714758
26	MP0001293_anophthalmia	1.59386188
27	MP0004133_heterotaxia	1.57591719
28	MP0003890_abnormal_embryonic-extraembry	1.50673150
29	MP0008789_abnormal_olfactory_epithelium	1.47781753
30	MP0002733_abnormal_thermal_nociception	1.45415545
31	MP0001529_abnormal_vocalization	1.44782235
32	MP0005551_abnormal_eye_electrophysiolog	1.41911242
33	MP0005499_abnormal_olfactory_system	1.40908875
34	MP0005394_taste/olfaction_phenotype	1.40908875
35	MP0009745_abnormal_behavioral_response	1.39376217
36	MP0004145_abnormal_muscle_electrophysio	1.38070323
37	MP0004859_abnormal_synaptic_plasticity	1.33090483
38	MP0004885_abnormal_endolymph	1.32612917
39	MP0001501_abnormal_sleep_pattern	1.32259885
40	MP0001486_abnormal_startle_reflex	1.30385092
41	MP0006276_abnormal_autonomic_nervous	1.29201200
42	MP0003693_abnormal_embryo_hatching	1.24709218
43	MP0008872_abnormal_physiological_respon	1.23535125
44	MP0000778_abnormal_nervous_system	1.20862459
45	MP0002572_abnormal_emotion/affect_behav	1.20304864
46	MP0001970_abnormal_pain_threshold	1.18931945
47	MP0000049_abnormal_middle_ear	1.17815013
48	MP0002234_abnormal_pharynx_morphology	1.16235854
49	MP0002163_abnormal_gland_morphology	1.15276092
50	MP0004742_abnormal_vestibular_system	1.14940839
51	MP0001986_abnormal_taste_sensitivity	1.13550504
52	MP0002277_abnormal_respiratory_mucosa	1.13127968
53	MP0003119_abnormal_digestive_system	1.12967840
54	MP0005377_hearing/vestibular/ear_phenot	1.12309851
55	MP0003878_abnormal_ear_physiology	1.12309851
56	MP0004043_abnormal_pH_regulation	1.11862625
57	MP0001984_abnormal_olfaction	1.11814783
58	MP0008058_abnormal_DNA_repair	1.11411612
59	MP0002184_abnormal_innervation	1.09720327
60	MP0005084_abnormal_gallbladder_morpholo	1.09489656
61	MP0003186_abnormal_redox_activity	1.09092051
62	MP0005670_abnormal_white_adipose	1.08628309
63	MP0001905_abnormal_dopamine_level	1.05889014
64	MP0000955_abnormal_spinal_cord	1.04874869
65	MP0004270_analgesia	1.04178295
66	MP0000613_abnormal_salivary_gland	1.03993389
67	MP0001348_abnormal_lacrimal_gland	1.03496800
68	MP0003635_abnormal_synaptic_transmissio	1.03374942
69	MP0002735_abnormal_chemical_nociception	1.02932050
70	MP0003938_abnormal_ear_development	1.02499468
71	MP0008961_abnormal_basal_metabolism	1.01891671
72	MP0002837_dystrophic_cardiac_calcinosis	1.00053170
73	MP0000631_abnormal_neuroendocrine_gland	0.99178893
74	MP0002557_abnormal_social/conspecific_i	0.99030045
75	MP0002752_abnormal_somatic_nervous	0.97399003
76	MP0002063_abnormal_learning/memory/cond	0.96684887
77	MP0001440_abnormal_grooming_behavior	0.95836789
78	MP0003183_abnormal_peptide_metabolism	0.95093750
79	MP0002938_white_spotting	0.92895891
80	MP0010094_abnormal_chromosome_stability	0.92422819
81	MP0002067_abnormal_sensory_capabilities	0.92179019
82	MP0002734_abnormal_mechanical_nocicepti	0.91485627
83	MP0005410_abnormal_fertilization	0.90928356
84	MP0002138_abnormal_hepatobiliary_system	0.88170035
85	MP0001286_abnormal_eye_development	0.88090082
86	MP0000537_abnormal_urethra_morphology	0.87844560
87	MP0005195_abnormal_posterior_eye	0.86165183
88	MP0002882_abnormal_neuron_morphology	0.84042326
89	MP0005253_abnormal_eye_physiology	0.83808875
90	MP0002233_abnormal_nose_morphology	0.83536785
91	MP0002210_abnormal_sex_determination	0.83457457
92	MP0002160_abnormal_reproductive_system	0.83294445
93	MP0005671_abnormal_response_to	0.82839566
94	MP0000685_abnormal_immune_system	0.81165539
95	MP0000534_abnormal_ureter_morphology	0.80885209
96	MP0005167_abnormal_blood-brain_barrier	0.79879811
97	MP0006036_abnormal_mitochondrial_physio	0.78972552
98	MP0002095_abnormal_skin_pigmentation	0.78935040
99	MP0002064_seizures	0.78417826
100	MP0003937_abnormal_limbs/digits/tail_de	0.77629825

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Failure to thrive in infancy (HP:0001531)	4.83349052
2	Abnormality of the labia minora (HP:0012880)	4.10187015
3	Rib fusion (HP:0000902)	3.81236511
4	Acute necrotizing encephalopathy (HP:0006965)	3.75249890
5	Febrile seizures (HP:0002373)	3.64947786
6	Acute encephalopathy (HP:0006846)	3.44752552
7	Reticulocytopenia (HP:0001896)	3.31407733
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.29422628
9	Abnormal respiratory epithelium morphology (HP:0012253)	3.15598326
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.15598326
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.12486131
12	Supernumerary spleens (HP:0009799)	2.96876095
13	Progressive macrocephaly (HP:0004481)	2.95991830
14	Hyperglycinemia (HP:0002154)	2.95016364
15	Methylmalonic acidemia (HP:0002912)	2.93943602
16	Increased CSF lactate (HP:0002490)	2.92724906
17	Congenital, generalized hypertrichosis (HP:0004540)	2.90829418
18	Mitochondrial inheritance (HP:0001427)	2.90736370
19	Medial flaring of the eyebrow (HP:0010747)	2.88608692
20	Nephronophthisis (HP:0000090)	2.85424326
21	Stenosis of the external auditory canal (HP:0000402)	2.85063507
22	Abnormality of midbrain morphology (HP:0002418)	2.83751302
23	Molar tooth sign on MRI (HP:0002419)	2.83751302
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.76284640
25	Absent/shortened dynein arms (HP:0200106)	2.76284640
26	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.62428230
27	Congenital stationary night blindness (HP:0007642)	2.61484796
28	Colon cancer (HP:0003003)	2.55814375
29	Cerebral edema (HP:0002181)	2.55260112
30	Abnormality of the renal medulla (HP:0100957)	2.52790176
31	Methylmalonic aciduria (HP:0012120)	2.50213155
32	Median cleft lip (HP:0000161)	2.46839322
33	Pancreatic cysts (HP:0001737)	2.41573958
34	Abnormality of methionine metabolism (HP:0010901)	2.40992991
35	Thyroid-stimulating hormone excess (HP:0002925)	2.38414478
36	Hepatocellular necrosis (HP:0001404)	2.32164028
37	Absent thumb (HP:0009777)	2.31079539
38	Optic disc pallor (HP:0000543)	2.30589375
39	Focal motor seizures (HP:0011153)	2.30411659
40	Abnormal number of erythroid precursors (HP:0012131)	2.29183358
41	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.29182670
42	Lissencephaly (HP:0001339)	2.28375269
43	Abnormal respiratory motile cilium physiology (HP:0012261)	2.27943653
44	Pancreatic fibrosis (HP:0100732)	2.27306793
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.26489344
46	Birth length less than 3rd percentile (HP:0003561)	2.24568663
47	Genetic anticipation (HP:0003743)	2.23207266
48	Macrocytic anemia (HP:0001972)	2.21405680
49	Septo-optic dysplasia (HP:0100842)	2.19761988
50	Hyperglycinuria (HP:0003108)	2.18949498
51	True hermaphroditism (HP:0010459)	2.18529687
52	Abnormal ciliary motility (HP:0012262)	2.16266850
53	Sclerocornea (HP:0000647)	2.15732475
54	Hepatic necrosis (HP:0002605)	2.14851212
55	Increased hepatocellular lipid droplets (HP:0006565)	2.12903957
56	Oligodactyly (hands) (HP:0001180)	2.10171987
57	Increased serum lactate (HP:0002151)	2.07331941
58	Impulsivity (HP:0100710)	2.06897447
59	Pallor (HP:0000980)	2.06235267
60	Oligodactyly (HP:0012165)	2.06176069
61	Lipid accumulation in hepatocytes (HP:0006561)	2.03277081
62	Abnormality of serum amino acid levels (HP:0003112)	2.01942122
63	Adrenal hypoplasia (HP:0000835)	2.00977123
64	Rhinitis (HP:0012384)	1.99341915
65	Chronic bronchitis (HP:0004469)	1.99193595
66	Hip dysplasia (HP:0001385)	1.98007711
67	Abnormality of the renal cortex (HP:0011035)	1.96536997
68	Small hand (HP:0200055)	1.94419647
69	Pendular nystagmus (HP:0012043)	1.93365346
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.90693457
71	Anomalous pulmonary venous return (HP:0010772)	1.90193950
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90168130
73	Pachygyria (HP:0001302)	1.89322876
74	Abnormality of the renal collecting system (HP:0004742)	1.88616080
75	Increased corneal curvature (HP:0100692)	1.88556934
76	Keratoconus (HP:0000563)	1.88556934
77	Facial hemangioma (HP:0000329)	1.86870735
78	Retinal dysplasia (HP:0007973)	1.85217568
79	Abnormality of homocysteine metabolism (HP:0010919)	1.85166629
80	Homocystinuria (HP:0002156)	1.85166629
81	Asplenia (HP:0001746)	1.83879386
82	Renal Fanconi syndrome (HP:0001994)	1.83230990
83	Renal hypoplasia (HP:0000089)	1.82427903
84	Increased intramyocellular lipid droplets (HP:0012240)	1.79425146
85	Abnormal lung lobation (HP:0002101)	1.77031188
86	Gait imbalance (HP:0002141)	1.76973441
87	Tubulointerstitial nephritis (HP:0001970)	1.75428667
88	Limb hypertonia (HP:0002509)	1.75317805
89	Narrow forehead (HP:0000341)	1.75316757
90	Agitation (HP:0000713)	1.74935785
91	Lethargy (HP:0001254)	1.72628022
92	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72313437
93	Chromsome breakage (HP:0040012)	1.72167927
94	Triphalangeal thumb (HP:0001199)	1.70975105
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.70347782
96	Abnormality of glycine metabolism (HP:0010895)	1.70347782
97	Postaxial hand polydactyly (HP:0001162)	1.69518638
98	Fair hair (HP:0002286)	1.69302726
99	Tubular atrophy (HP:0000092)	1.69100373
100	Meckel diverticulum (HP:0002245)	1.68855137

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	4.70206925
2	STK16	3.35341124
3	MAP3K4	2.66971981
4	TRIM28	2.51754800
5	MAP2K7	2.50482897
6	MAP4K2	2.44490492
7	VRK2	2.31831383
8	WNK3	2.22888797
9	NUAK1	2.14030883
10	FGFR3	2.08592471
11	EPHB2	2.04372463
12	SRPK1	2.02969694
13	MARK1	2.01161209
14	BCKDK	1.88812593
15	MAPK13	1.76894445
16	DYRK1A	1.72705463
17	GRK1	1.67075361
18	FRK	1.63860168
19	MKNK2	1.61405034
20	NEK1	1.57689203
21	DYRK2	1.57228535
22	WNK4	1.56577630
23	ZAK	1.53870567
24	BCR	1.49967363
25	CAMKK2	1.47204529
26	TAOK3	1.45384930
27	PIK3CA	1.41425838
28	PLK4	1.37529658
29	PHKG2	1.32646714
30	PHKG1	1.32646714
31	PLK3	1.28513836
32	MAP2K4	1.27343052
33	VRK1	1.24460678
34	PRKCG	1.18434779
35	ADRBK2	1.12291505
36	TSSK6	1.11413659
37	PLK2	1.10865281
38	PASK	1.06743107
39	MAP3K6	1.06638839
40	BUB1	1.06257556
41	EIF2AK1	1.06068578
42	TLK1	1.04008732
43	NME1	0.99411303
44	MST4	0.98569620
45	TNIK	0.95838256
46	OXSR1	0.94338802
47	PNCK	0.93046934
48	ERBB2	0.92280968
49	CASK	0.84279307
50	BRSK2	0.84271432
51	CDC7	0.84185213
52	CSNK1G2	0.83729752
53	PLK1	0.83067410
54	NTRK2	0.81472069
55	CLK1	0.80242084
56	DAPK1	0.79090392
57	STK39	0.77933526
58	EPHA4	0.76315456
59	MKNK1	0.75403546
60	CSNK1E	0.74678289
61	CSNK1G3	0.74221576
62	ADRBK1	0.72504888
63	INSRR	0.72171689
64	TIE1	0.71740714
65	PINK1	0.71166887
66	MAP3K12	0.68750301
67	MATK	0.67129110
68	CAMKK1	0.65386845
69	CSNK1G1	0.65233621
70	AURKA	0.63062797
71	EIF2AK2	0.60520302
72	MINK1	0.60277608
73	AURKB	0.59134987
74	CSNK1A1L	0.58441384
75	STK38L	0.55075377
76	ATR	0.52400419
77	PAK3	0.51943267
78	ABL2	0.51668620
79	MAPKAPK3	0.50998479
80	CAMK2B	0.49366229
81	TEC	0.48861973
82	BRSK1	0.48432093
83	DAPK2	0.46534586
84	PRKACA	0.45545243
85	PTK6	0.45348363
86	PRKCE	0.44697771
87	CAMK2A	0.43308270
88	PRKCI	0.42799500
89	MYLK	0.42626048
90	CDK8	0.41521953
91	SGK1	0.40749665
92	CHEK2	0.40576960
93	WEE1	0.37941465
94	PRKCZ	0.37548832
95	DAPK3	0.37436929
96	CSNK2A1	0.37202006
97	PRKACB	0.36515478
98	CSNK2A2	0.36206895
99	BMPR2	0.36048371
100	CAMK2D	0.35102120

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.12032514
2	Proteasome_Homo sapiens_hsa03050	3.04664463
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01888234
4	Ribosome_Homo sapiens_hsa03010	2.99472225
5	Propanoate metabolism_Homo sapiens_hsa00640	2.75631132
6	Parkinsons disease_Homo sapiens_hsa05012	2.69920030
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.56506425
8	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.39525331
9	Protein export_Homo sapiens_hsa03060	2.38107042
10	Homologous recombination_Homo sapiens_hsa03440	2.20587309
11	Basal transcription factors_Homo sapiens_hsa03022	2.09775537
12	Butanoate metabolism_Homo sapiens_hsa00650	2.02060948
13	Huntingtons disease_Homo sapiens_hsa05016	1.99600325
14	RNA polymerase_Homo sapiens_hsa03020	1.79197728
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76675723
16	Nicotine addiction_Homo sapiens_hsa05033	1.74157626
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.73832838
18	Caffeine metabolism_Homo sapiens_hsa00232	1.71310227
19	RNA degradation_Homo sapiens_hsa03018	1.70342706
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68253135
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66355066
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.62018305
23	Mismatch repair_Homo sapiens_hsa03430	1.60642445
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.59561971
25	Alzheimers disease_Homo sapiens_hsa05010	1.52615931
26	DNA replication_Homo sapiens_hsa03030	1.44077993
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41992637
28	Taste transduction_Homo sapiens_hsa04742	1.39469248
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.39127439
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37276550
31	Phototransduction_Homo sapiens_hsa04744	1.36902727
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36108437
33	One carbon pool by folate_Homo sapiens_hsa00670	1.34727232
34	Spliceosome_Homo sapiens_hsa03040	1.33672859
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29767689
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29649142
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23372791
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.21321303
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.16040075
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06645949
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06158645
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02917595
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98547608
44	Base excision repair_Homo sapiens_hsa03410	0.96880700
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.94888689
46	Morphine addiction_Homo sapiens_hsa05032	0.90699200
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90602386
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.90122484
49	Purine metabolism_Homo sapiens_hsa00230	0.88761919
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88402012
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87412455
52	GABAergic synapse_Homo sapiens_hsa04727	0.85079186
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.84584021
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.84401480
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83863084
56	Retinol metabolism_Homo sapiens_hsa00830	0.83758159
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80837194
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80494603
59	Peroxisome_Homo sapiens_hsa04146	0.76221849
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.74303483
61	Metabolic pathways_Homo sapiens_hsa01100	0.74248932
62	Asthma_Homo sapiens_hsa05310	0.74246835
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74028300
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.68415064
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.68070720
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67279372
67	Circadian entrainment_Homo sapiens_hsa04713	0.65209544
68	RNA transport_Homo sapiens_hsa03013	0.63369007
69	Sulfur relay system_Homo sapiens_hsa04122	0.61971031
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59358762
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58390313
72	Olfactory transduction_Homo sapiens_hsa04740	0.58340725
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55716977
74	Axon guidance_Homo sapiens_hsa04360	0.54506675
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53979482
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53477434
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50344244
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46690899
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46365605
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45733726
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.42468375
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.40825063
83	Sulfur metabolism_Homo sapiens_hsa00920	0.40109421
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38922307
85	Serotonergic synapse_Homo sapiens_hsa04726	0.36153642
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.36087090
87	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.36059243
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35295888
89	Oocyte meiosis_Homo sapiens_hsa04114	0.32936743
90	Cocaine addiction_Homo sapiens_hsa05030	0.32496931
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28842441
92	Insulin secretion_Homo sapiens_hsa04911	0.28342104
93	Mineral absorption_Homo sapiens_hsa04978	0.28206189
94	Folate biosynthesis_Homo sapiens_hsa00790	0.28147100
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.25751151
96	p53 signaling pathway_Homo sapiens_hsa04115	0.24946632
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.24375613
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.23618909
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.22024089
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20586139

HMGB1P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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