HMGB1P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.38219670
2L-fucose catabolic process (GO:0042355)4.88473031
3fucose catabolic process (GO:0019317)4.88473031
4L-fucose metabolic process (GO:0042354)4.88473031
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.80204917
6protein neddylation (GO:0045116)4.67680717
7viral transcription (GO:0019083)4.65159345
8behavioral response to nicotine (GO:0035095)4.58898065
9ribosomal small subunit assembly (GO:0000028)4.53403553
10cellular ketone body metabolic process (GO:0046950)4.43299457
11translational termination (GO:0006415)4.39336056
12axonemal dynein complex assembly (GO:0070286)4.37552688
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18575148
14DNA deamination (GO:0045006)4.10237882
15piRNA metabolic process (GO:0034587)4.01162113
16spinal cord association neuron differentiation (GO:0021527)3.97295440
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.95515333
18pyrimidine nucleotide catabolic process (GO:0006244)3.93153958
19ketone body metabolic process (GO:1902224)3.91955430
20cell proliferation in forebrain (GO:0021846)3.86774702
21translational elongation (GO:0006414)3.85129262
22maturation of SSU-rRNA (GO:0030490)3.78201295
23epithelial cilium movement (GO:0003351)3.72863166
24ATP synthesis coupled proton transport (GO:0015986)3.72422530
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72422530
26ribosomal large subunit biogenesis (GO:0042273)3.67735842
27cilium movement (GO:0003341)3.62613966
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62200301
29cotranslational protein targeting to membrane (GO:0006613)3.60035276
30pattern specification involved in kidney development (GO:0061004)3.57062702
31protein targeting to ER (GO:0045047)3.56154653
32substrate-independent telencephalic tangential migration (GO:0021826)3.55294467
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.55294467
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.51796969
35protein-cofactor linkage (GO:0018065)3.51785900
36segment specification (GO:0007379)3.49608085
37vitamin transmembrane transport (GO:0035461)3.46179280
38hypothalamus development (GO:0021854)3.43236802
39DNA strand renaturation (GO:0000733)3.38951434
40base-excision repair, AP site formation (GO:0006285)3.37052474
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36601860
42protein localization to endoplasmic reticulum (GO:0070972)3.30958484
43cellular protein complex disassembly (GO:0043624)3.30929077
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28713404
45ribosomal small subunit biogenesis (GO:0042274)3.24833291
46positive regulation of prostaglandin secretion (GO:0032308)3.24130824
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23909946
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.23909946
49NADH dehydrogenase complex assembly (GO:0010257)3.23909946
50rRNA catabolic process (GO:0016075)3.23423186
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22599451
52axoneme assembly (GO:0035082)3.18929936
53ubiquinone biosynthetic process (GO:0006744)3.18832304
54viral life cycle (GO:0019058)3.17930724
55regulation of microtubule-based movement (GO:0060632)3.15559326
56GTP biosynthetic process (GO:0006183)3.13107659
57motile cilium assembly (GO:0044458)3.13050421
58telencephalon development (GO:0021537)3.12669011
59water-soluble vitamin biosynthetic process (GO:0042364)3.11708887
60chromatin remodeling at centromere (GO:0031055)3.08239943
61positive regulation of fatty acid transport (GO:2000193)3.08014895
62intraciliary transport (GO:0042073)3.05913553
63deoxyribonucleotide catabolic process (GO:0009264)3.04864239
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.02452722
65replication fork processing (GO:0031297)3.00883428
66protein complex biogenesis (GO:0070271)3.00837105
67DNA methylation involved in gamete generation (GO:0043046)2.99650783
68negative regulation of telomere maintenance (GO:0032205)2.99569616
69neuron fate determination (GO:0048664)2.99425417
70phosphatidylinositol acyl-chain remodeling (GO:0036149)2.95018760
71radial glial cell differentiation (GO:0060019)2.94405626
72protein polyglutamylation (GO:0018095)2.93417392
73somite development (GO:0061053)2.93028766
74ubiquinone metabolic process (GO:0006743)2.89380042
75chaperone-mediated protein transport (GO:0072321)2.85686595
76protein complex disassembly (GO:0043241)2.85227636
77RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.84427196
78mitochondrial respiratory chain complex assembly (GO:0033108)2.83933090
79pyrimidine-containing compound transmembrane transport (GO:0072531)2.82439529
80deoxyribose phosphate catabolic process (GO:0046386)2.82430113
81transmission of nerve impulse (GO:0019226)2.81509229
82translational initiation (GO:0006413)2.79208029
83positive regulation of icosanoid secretion (GO:0032305)2.78116173
84regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78053341
85nonmotile primary cilium assembly (GO:0035058)2.76581789
86macromolecular complex disassembly (GO:0032984)2.75398155
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75339410
88pyrimidine nucleobase catabolic process (GO:0006208)2.74822315
89nephron epithelium morphogenesis (GO:0072088)2.71819729
90nephron tubule morphogenesis (GO:0072078)2.71819729
91regulation of gene silencing by RNA (GO:0060966)2.68010229
92regulation of posttranscriptional gene silencing (GO:0060147)2.68010229
93regulation of gene silencing by miRNA (GO:0060964)2.68010229
94interleukin-1-mediated signaling pathway (GO:0070498)2.65544065
95regulation of cilium movement (GO:0003352)2.61530817
96neuronal action potential propagation (GO:0019227)2.60545449
97response to pheromone (GO:0019236)2.60055296
98short-term memory (GO:0007614)2.60021368
99CENP-A containing nucleosome assembly (GO:0034080)2.59149076
100ribonucleoprotein complex biogenesis (GO:0022613)2.58675799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77799809
2ZNF274_21170338_ChIP-Seq_K562_Hela3.83494515
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.29107167
4IRF1_19129219_ChIP-ChIP_H3396_Human2.76067499
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.66028933
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.54971845
7VDR_22108803_ChIP-Seq_LS180_Human2.52208894
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.51556412
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51474068
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31174792
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25020267
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.02110256
13IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82375672
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80723458
15IGF1R_20145208_ChIP-Seq_DFB_Human1.78177526
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74927932
17TAF2_19829295_ChIP-Seq_ESCs_Human1.72762707
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71043478
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67349242
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.64081285
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58795790
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.57847228
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55641906
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55024351
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54179400
26MYC_18940864_ChIP-ChIP_HL60_Human1.50788223
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.50669605
28GATA3_21878914_ChIP-Seq_MCF-7_Human1.49493968
29ERA_21632823_ChIP-Seq_H3396_Human1.48705373
30REST_21632747_ChIP-Seq_MESCs_Mouse1.47798864
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47427136
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.45288696
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42371325
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41726875
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.39878810
36TP53_22573176_ChIP-Seq_HFKS_Human1.38587796
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35492356
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32948528
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32755364
40EWS_26573619_Chip-Seq_HEK293_Human1.32323059
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32114921
42CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.31274213
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29899411
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25325272
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23276128
46ER_23166858_ChIP-Seq_MCF-7_Human1.22255063
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20764159
48RNF2_27304074_Chip-Seq_NSC_Mouse1.18770459
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18140640
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17043081
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16562399
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16017654
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.16017654
54FOXP3_21729870_ChIP-Seq_TREG_Human1.15477405
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14597638
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14461388
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.14366529
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14355437
59NANOG_20526341_ChIP-Seq_ESCs_Human1.14016502
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13132286
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.13072297
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.12199990
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10354094
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09834825
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09631343
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09631343
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.08642331
68ELK1_19687146_ChIP-ChIP_HELA_Human1.08354795
69MYC_19829295_ChIP-Seq_ESCs_Human1.08332935
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07827393
71NCOR_22424771_ChIP-Seq_293T_Human1.07666782
72HOXB7_26014856_ChIP-Seq_BT474_Human1.06023992
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06009443
74P53_21459846_ChIP-Seq_SAOS-2_Human1.05824271
75VDR_23849224_ChIP-Seq_CD4+_Human1.05376453
76FOXH1_21741376_ChIP-Seq_ESCs_Human1.04766048
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03105843
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99647749
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99481085
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99368253
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.99286972
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.99049592
83OCT4_19829295_ChIP-Seq_ESCs_Human0.98919406
84E2F1_20622854_ChIP-Seq_HELA_Human0.98884504
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98645469
86THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98547206
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.98254891
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97730419
89BCAT_22108803_ChIP-Seq_LS180_Human0.97721806
90P300_19829295_ChIP-Seq_ESCs_Human0.97249662
91OCT4_20526341_ChIP-Seq_ESCs_Human0.94932634
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.94304260
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94202387
94E2F7_22180533_ChIP-Seq_HELA_Human0.93088068
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92778169
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91272482
97P300_27268052_Chip-Seq_Bcells_Human0.91261898
98TTF2_22483619_ChIP-Seq_HELA_Human0.91014655
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90744564
100CTCF_20526341_ChIP-Seq_ESCs_Human0.90691817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.95394105
2MP0002102_abnormal_ear_morphology3.83938357
3MP0002653_abnormal_ependyma_morphology3.69999200
4MP0002163_abnormal_gland_morphology3.16622626
5MP0005379_endocrine/exocrine_gland_phen3.04091771
6MP0009379_abnormal_foot_pigmentation2.74694127
7MP0008877_abnormal_DNA_methylation2.68833943
8MP0004885_abnormal_endolymph2.61276190
9MP0003195_calcinosis2.60160972
10MP0008789_abnormal_olfactory_epithelium2.54627182
11MP0001293_anophthalmia2.48794210
12MP0001348_abnormal_lacrimal_gland2.37697054
13MP0005394_taste/olfaction_phenotype2.19909116
14MP0005499_abnormal_olfactory_system2.19909116
15MP0004147_increased_porphyrin_level2.11410369
16MP0003878_abnormal_ear_physiology2.08032466
17MP0005377_hearing/vestibular/ear_phenot2.08032466
18MP0003646_muscle_fatigue2.06360896
19MP0003787_abnormal_imprinting2.01943799
20MP0004142_abnormal_muscle_tone1.82926266
21MP0003136_yellow_coat_color1.79810711
22MP0000049_abnormal_middle_ear1.74098572
23MP0000778_abnormal_nervous_system1.72549047
24MP0008875_abnormal_xenobiotic_pharmacok1.72521789
25MP0000372_irregular_coat_pigmentation1.62031530
26MP0002736_abnormal_nociception_after1.59803329
27MP0001968_abnormal_touch/_nociception1.59787580
28MP0001529_abnormal_vocalization1.58875892
29MP0005551_abnormal_eye_electrophysiolog1.51352137
30MP0001984_abnormal_olfaction1.49159876
31MP0004742_abnormal_vestibular_system1.42991656
32MP0003122_maternal_imprinting1.41203204
33MP0002095_abnormal_skin_pigmentation1.36693168
34MP0005423_abnormal_somatic_nervous1.35070590
35MP0010030_abnormal_orbit_morphology1.33277301
36MP0002876_abnormal_thyroid_physiology1.32764494
37MP0002272_abnormal_nervous_system1.32388815
38MP0008872_abnormal_physiological_respon1.31886843
39MP0009745_abnormal_behavioral_response1.30621096
40MP0006276_abnormal_autonomic_nervous1.30430988
41MP0003121_genomic_imprinting1.29214581
42MP0003011_delayed_dark_adaptation1.26364353
43MP0004133_heterotaxia1.25619264
44MP0002557_abnormal_social/conspecific_i1.25207809
45MP0000026_abnormal_inner_ear1.21120132
46MP0002160_abnormal_reproductive_system1.18959805
47MP0000427_abnormal_hair_cycle1.18227942
48MP0005389_reproductive_system_phenotype1.17814272
49MP0002837_dystrophic_cardiac_calcinosis1.17080048
50MP0002733_abnormal_thermal_nociception1.15260656
51MP0004145_abnormal_muscle_electrophysio1.13209247
52MP0001986_abnormal_taste_sensitivity1.12790080
53MP0001486_abnormal_startle_reflex1.12511747
54MP0001440_abnormal_grooming_behavior1.12174531
55MP0002063_abnormal_learning/memory/cond1.11618827
56MP0005645_abnormal_hypothalamus_physiol1.10884409
57MP0003635_abnormal_synaptic_transmissio1.08670017
58MP0002572_abnormal_emotion/affect_behav1.06679530
59MP0001970_abnormal_pain_threshold1.06392470
60MP0005195_abnormal_posterior_eye1.06229491
61MP0005646_abnormal_pituitary_gland1.06220740
62MP0002233_abnormal_nose_morphology1.01179217
63MP0000631_abnormal_neuroendocrine_gland0.99877294
64MP0002938_white_spotting0.99457726
65MP0001485_abnormal_pinna_reflex0.98504396
66MP0002752_abnormal_somatic_nervous0.97947307
67MP0008775_abnormal_heart_ventricle0.96939528
68MP0005365_abnormal_bile_salt0.95068473
69MP0003880_abnormal_central_pattern0.94741424
70MP0005391_vision/eye_phenotype0.89577183
71MP0002210_abnormal_sex_determination0.89114494
72MP0005253_abnormal_eye_physiology0.85769528
73MP0000647_abnormal_sebaceous_gland0.85309555
74MP0004043_abnormal_pH_regulation0.84866017
75MP0000955_abnormal_spinal_cord0.84422674
76MP0004130_abnormal_muscle_cell0.84161438
77MP0005187_abnormal_penis_morphology0.83975539
78MP0002735_abnormal_chemical_nociception0.83657041
79MP0002184_abnormal_innervation0.83023139
80MP0006072_abnormal_retinal_apoptosis0.81042906
81MP0003698_abnormal_male_reproductive0.80120975
82MP0001919_abnormal_reproductive_system0.79989476
83MP0001929_abnormal_gametogenesis0.78274951
84MP0001963_abnormal_hearing_physiology0.78242599
85MP0000230_abnormal_systemic_arterial0.78186131
86MP0001286_abnormal_eye_development0.77820814
87MP0002067_abnormal_sensory_capabilities0.76586625
88MP0001502_abnormal_circadian_rhythm0.74600099
89MP0004924_abnormal_behavior0.73074580
90MP0005386_behavior/neurological_phenoty0.73074580
91MP0002064_seizures0.72119512
92MP0002234_abnormal_pharynx_morphology0.70759952
93MP0002882_abnormal_neuron_morphology0.70138878
94MP0003119_abnormal_digestive_system0.70114087
95MP0002152_abnormal_brain_morphology0.70060525
96MP0000685_abnormal_immune_system0.69531979
97MP0005085_abnormal_gallbladder_physiolo0.67988457
98MP0002132_abnormal_respiratory_system0.66746505
99MP0009840_abnormal_foam_cell0.64854611
100MP0000653_abnormal_sex_gland0.64570518

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.68162843
2Abnormality of midbrain morphology (HP:0002418)4.36802001
3Molar tooth sign on MRI (HP:0002419)4.36802001
4Metabolic alkalosis (HP:0200114)4.12819058
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.93280779
6Absent/shortened dynein arms (HP:0200106)3.93280779
7Hypokalemic alkalosis (HP:0001949)3.67726725
8Abnormal ciliary motility (HP:0012262)3.67368688
9Abnormal respiratory epithelium morphology (HP:0012253)3.49735619
10Abnormal respiratory motile cilium morphology (HP:0005938)3.49735619
11Pancreatic cysts (HP:0001737)3.32551623
12Abnormality of cells of the erythroid lineage (HP:0012130)3.30069718
13Pancreatic fibrosis (HP:0100732)3.27062265
14Abnormal respiratory motile cilium physiology (HP:0012261)3.23008011
15Increased circulating renin level (HP:0000848)3.16621019
16Chronic hepatic failure (HP:0100626)3.12125342
17Type II lissencephaly (HP:0007260)3.09469753
18Polyuria (HP:0000103)3.01997672
19Nephronophthisis (HP:0000090)2.97800276
20Acute necrotizing encephalopathy (HP:0006965)2.88411946
21Abnormality of the labia minora (HP:0012880)2.86378264
22Abnormal number of erythroid precursors (HP:0012131)2.84404312
23True hermaphroditism (HP:0010459)2.77807495
24Hyperaldosteronism (HP:0000859)2.72352179
25Decreased central vision (HP:0007663)2.71654876
26Confusion (HP:0001289)2.70884357
27Renal salt wasting (HP:0000127)2.70164851
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66463755
29Macrocytic anemia (HP:0001972)2.65206965
30Acute encephalopathy (HP:0006846)2.64683636
31Retinal dysplasia (HP:0007973)2.62364053
32Hyperactive renin-angiotensin system (HP:0000841)2.58509359
33Alkalosis (HP:0001948)2.57569046
34Concave nail (HP:0001598)2.54326969
35Rhinitis (HP:0012384)2.51644199
36Abnormality of chloride homeostasis (HP:0011422)2.47706750
37Ectopic kidney (HP:0000086)2.45234506
38Pallor (HP:0000980)2.44000961
39Abnormality of alanine metabolism (HP:0010916)2.41585476
40Hyperalaninemia (HP:0003348)2.41585476
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41585476
42Anophthalmia (HP:0000528)2.39770152
43Abnormal urine output (HP:0012590)2.38472433
44Abnormal mitochondria in muscle tissue (HP:0008316)2.37444422
45Abnormality of the renal medulla (HP:0100957)2.36550351
46Rib fusion (HP:0000902)2.35325608
47Inability to walk (HP:0002540)2.31546700
48Lissencephaly (HP:0001339)2.30062646
49Supernumerary spleens (HP:0009799)2.29854036
50Myokymia (HP:0002411)2.29264311
51Mitochondrial inheritance (HP:0001427)2.25679812
52Depressed nasal ridge (HP:0000457)2.23597742
53Sclerocornea (HP:0000647)2.21170843
54Optic disc pallor (HP:0000543)2.19029563
55Pendular nystagmus (HP:0012043)2.16256318
56Progressive macrocephaly (HP:0004481)2.15104521
57Chronic sinusitis (HP:0011109)2.15084289
58Hyperglycinemia (HP:0002154)2.14416290
59Mutism (HP:0002300)2.14245064
60Absent thumb (HP:0009777)2.13662440
61Abnormality of renal excretion (HP:0011036)2.12560460
62Polyphagia (HP:0002591)2.12554664
6311 pairs of ribs (HP:0000878)2.12261633
64Abnormality of the renal collecting system (HP:0004742)2.10617404
65Abnormality of DNA repair (HP:0003254)2.10539459
66Birth length less than 3rd percentile (HP:0003561)2.09681352
67Duplicated collecting system (HP:0000081)2.09293959
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08182712
69Cystic liver disease (HP:0006706)2.05485554
70Increased CSF lactate (HP:0002490)2.01674623
71Hypokalemia (HP:0002900)1.99187626
723-Methylglutaconic aciduria (HP:0003535)1.98353916
73Congenital stationary night blindness (HP:0007642)1.97009767
74Oligodactyly (hands) (HP:0001180)1.96188827
75Chronic bronchitis (HP:0004469)1.95703603
76Colon cancer (HP:0003003)1.93757935
77Abnormality of renal resorption (HP:0011038)1.93242518
78Tubular atrophy (HP:0000092)1.91296879
79Morphological abnormality of the pyramidal tract (HP:0002062)1.91045828
80Cerebral edema (HP:0002181)1.90953610
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88846751
82Attenuation of retinal blood vessels (HP:0007843)1.88549798
83Abnormality of renin-angiotensin system (HP:0000847)1.87319975
84Partial agenesis of the corpus callosum (HP:0001338)1.85801556
85Thyroid-stimulating hormone excess (HP:0002925)1.85708579
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.85476578
87Medial flaring of the eyebrow (HP:0010747)1.85352169
88Abnormal hemoglobin (HP:0011902)1.85065366
89Anencephaly (HP:0002323)1.83407157
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81374100
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.80376660
92Abnormality of the vertebral endplates (HP:0005106)1.78780395
93Aplasia/Hypoplasia of the patella (HP:0006498)1.77445379
94Broad-based gait (HP:0002136)1.77120604
95Patellar aplasia (HP:0006443)1.76617722
96Tachypnea (HP:0002789)1.76358045
97Horseshoe kidney (HP:0000085)1.76010815
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74505202
99Abnormal rod and cone electroretinograms (HP:0008323)1.73403794
100Papilledema (HP:0001085)1.72343107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.10845260
2NEK13.35823819
3ADRBK23.35564587
4TLK13.24180349
5NUAK12.45858298
6STK162.44421597
7BCKDK2.29332452
8CAMK1D1.93870759
9MARK11.87979517
10WNK11.86154552
11NEK21.84603276
12DYRK21.83609109
13EPHB21.80035954
14ZAK1.66361759
15VRK21.65180599
16STK391.63305446
17PINK11.57590423
18BMPR1B1.44646614
19WNK31.38511432
20TAOK31.36878442
21PLK21.35080708
22CDC71.32786087
23DAPK21.31564142
24MAP2K21.28982650
25MAPK131.28752672
26STK111.26614403
27ADRBK11.25985167
28GRK11.18748358
29TIE11.16220880
30PLK41.13953740
31VRK11.13865467
32MAP4K21.13002697
33PRKCI1.11120901
34MAP3K41.10845870
35CAMKK11.09572353
36CAMK1G1.09118922
37TXK1.07252115
38PRKCG1.04605112
39FRK1.03242574
40WEE11.00549779
41CAMK10.99024827
42TAF10.97869057
43CAMKK20.96391744
44SIK20.94665343
45MAPK150.94468977
46CDC42BPA0.91754845
47MAP2K70.90656248
48PIK3CA0.88725372
49NTRK20.87247273
50MKNK10.86831089
51TESK20.83555222
52CDK190.82135424
53PLK30.81874150
54CASK0.81428592
55PRKCQ0.79305442
56ABL20.79139455
57PASK0.78271884
58RPS6KA50.77454096
59GRK70.76998653
60OXSR10.74595534
61CDK80.74420314
62MINK10.73276368
63ACVR1B0.72254183
64PAK60.70860555
65PDK20.69684009
66PLK10.68128985
67PAK30.65991704
68AURKB0.63947369
69TEC0.63517615
70AURKA0.63450889
71MKNK20.62092529
72RPS6KA60.61987542
73INSRR0.59837144
74MARK30.59751912
75MAP2K40.59265247
76PKN10.59138300
77PRKCH0.58363455
78BTK0.57022794
79BRSK10.56780948
80PRKACA0.55035888
81DYRK1A0.53017652
82NLK0.52803464
83TGFBR10.50655313
84OBSCN0.50632079
85ATR0.50416051
86KDR0.48383234
87MAP3K110.48302373
88CAMK40.47803294
89ITK0.47564237
90PHKG20.47552055
91PHKG10.47552055
92MARK20.46775533
93GRK50.46190729
94PRKCA0.43531670
95PIM10.42145657
96CSNK2A20.41911648
97EPHA40.40373888
98LIMK10.40284060
99PRKCZ0.39625452
100PRKCD0.38460852

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.85012628
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19657675
3Oxidative phosphorylation_Homo sapiens_hsa001902.82456300
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.80070831
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79942941
6Linoleic acid metabolism_Homo sapiens_hsa005912.57857322
7Homologous recombination_Homo sapiens_hsa034402.54796333
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40182773
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30379710
10Parkinsons disease_Homo sapiens_hsa050122.25425211
11Fanconi anemia pathway_Homo sapiens_hsa034602.15840916
12Phototransduction_Homo sapiens_hsa047442.10148073
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97410296
14Butanoate metabolism_Homo sapiens_hsa006501.97145081
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83339423
16Cardiac muscle contraction_Homo sapiens_hsa042601.80301345
17Mismatch repair_Homo sapiens_hsa034301.73574912
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68583971
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68406129
20Huntingtons disease_Homo sapiens_hsa050161.67309960
21RNA polymerase_Homo sapiens_hsa030201.65207312
22Sulfur relay system_Homo sapiens_hsa041221.56433253
23Caffeine metabolism_Homo sapiens_hsa002321.51219422
24Peroxisome_Homo sapiens_hsa041461.50659650
25Nicotine addiction_Homo sapiens_hsa050331.47808815
26Tryptophan metabolism_Homo sapiens_hsa003801.46639454
27Nitrogen metabolism_Homo sapiens_hsa009101.44456666
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.43841440
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42295813
30Proteasome_Homo sapiens_hsa030501.39344693
31Arachidonic acid metabolism_Homo sapiens_hsa005901.38876378
32Alzheimers disease_Homo sapiens_hsa050101.38792209
33Basal transcription factors_Homo sapiens_hsa030221.38761601
34Collecting duct acid secretion_Homo sapiens_hsa049661.38351845
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34345752
36RNA degradation_Homo sapiens_hsa030181.32547670
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31463203
38Propanoate metabolism_Homo sapiens_hsa006401.28689205
39Nucleotide excision repair_Homo sapiens_hsa034201.27123848
40Ether lipid metabolism_Homo sapiens_hsa005651.25647359
41DNA replication_Homo sapiens_hsa030301.21758510
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18074233
43Vitamin digestion and absorption_Homo sapiens_hsa049771.15261509
44Non-homologous end-joining_Homo sapiens_hsa034501.10127854
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.04627606
46Pyrimidine metabolism_Homo sapiens_hsa002401.01526789
47Morphine addiction_Homo sapiens_hsa050320.98598264
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97949532
49Selenocompound metabolism_Homo sapiens_hsa004500.97848427
50One carbon pool by folate_Homo sapiens_hsa006700.96435818
51Purine metabolism_Homo sapiens_hsa002300.96134444
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95185647
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.95110687
54Steroid biosynthesis_Homo sapiens_hsa001000.93618100
55Taste transduction_Homo sapiens_hsa047420.83280495
56Fat digestion and absorption_Homo sapiens_hsa049750.77302842
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76445502
58Primary immunodeficiency_Homo sapiens_hsa053400.70903629
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70367196
60RNA transport_Homo sapiens_hsa030130.70073599
61ABC transporters_Homo sapiens_hsa020100.68329316
62Insulin secretion_Homo sapiens_hsa049110.67429057
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66468201
64Retinol metabolism_Homo sapiens_hsa008300.63840628
65Serotonergic synapse_Homo sapiens_hsa047260.62261094
66Metabolic pathways_Homo sapiens_hsa011000.61081037
67Glutamatergic synapse_Homo sapiens_hsa047240.59999867
68Olfactory transduction_Homo sapiens_hsa047400.58179286
69Pyruvate metabolism_Homo sapiens_hsa006200.56396235
70Protein export_Homo sapiens_hsa030600.49632994
71Base excision repair_Homo sapiens_hsa034100.49395120
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49226525
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46868632
74Asthma_Homo sapiens_hsa053100.46558369
75Basal cell carcinoma_Homo sapiens_hsa052170.46172884
76Phenylalanine metabolism_Homo sapiens_hsa003600.45319678
77Ovarian steroidogenesis_Homo sapiens_hsa049130.42535343
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41525438
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40426414
80Fatty acid biosynthesis_Homo sapiens_hsa000610.39936203
81Chemical carcinogenesis_Homo sapiens_hsa052040.39910343
82Fatty acid degradation_Homo sapiens_hsa000710.38117579
83GABAergic synapse_Homo sapiens_hsa047270.37908280
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36108033
85Circadian entrainment_Homo sapiens_hsa047130.35375439
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34531717
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34228125
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.31183340
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30507717
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.30379049
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30144080
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26506119
93Axon guidance_Homo sapiens_hsa043600.25395103
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23665882
95mRNA surveillance pathway_Homo sapiens_hsa030150.23249771
96Oxytocin signaling pathway_Homo sapiens_hsa049210.21543325
97Mineral absorption_Homo sapiens_hsa049780.21106450
98Hedgehog signaling pathway_Homo sapiens_hsa043400.20226812
99beta-Alanine metabolism_Homo sapiens_hsa004100.19680094
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.18937421

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