ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	8.81468102
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.30438872
3	DNA deamination (GO:0045006)	6.44869088
4	response to pheromone (GO:0019236)	5.54414053
5	sequestering of actin monomers (GO:0042989)	5.41733554
6	negative regulation of sodium ion transport (GO:0010766)	5.38211221
7	cytidine deamination (GO:0009972)	5.35819831
8	cytidine metabolic process (GO:0046087)	5.35819831
9	cytidine catabolic process (GO:0006216)	5.35819831
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.15266920
11	regulation of action potential (GO:0098900)	4.64122456
12	ATP synthesis coupled proton transport (GO:0015986)	4.63332156
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.63332156
14	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.61560248
15	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.55928285
16	substrate-independent telencephalic tangential migration (GO:0021826)	4.55928285
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.55228617
18	chaperone-mediated protein transport (GO:0072321)	4.23353405
19	behavioral response to nicotine (GO:0035095)	4.13319528
20	axonemal dynein complex assembly (GO:0070286)	4.07169652
21	regulation of cell communication by electrical coupling (GO:0010649)	4.01498369
22	axoneme assembly (GO:0035082)	3.99250606
23	regulation of relaxation of muscle (GO:1901077)	3.99232126
24	epithelial cilium movement (GO:0003351)	3.88344358
25	protein complex biogenesis (GO:0070271)	3.79225382
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.72571522
27	cytochrome complex assembly (GO:0017004)	3.64884824
28	platelet dense granule organization (GO:0060155)	3.60500564
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60212900
30	cilium movement (GO:0003341)	3.58939409
31	regulation of cilium movement (GO:0003352)	3.58157852
32	protein polyglutamylation (GO:0018095)	3.55757567
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.52499100
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.51306468
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47801402
36	respiratory chain complex IV assembly (GO:0008535)	3.45473375
37	protein localization to cilium (GO:0061512)	3.39455564
38	intraciliary transport (GO:0042073)	3.34835637
39	electron transport chain (GO:0022900)	3.34181672
40	respiratory electron transport chain (GO:0022904)	3.32943814
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.20815814
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.20815814
43	base-excision repair, AP site formation (GO:0006285)	3.18582311
44	DNA demethylation (GO:0080111)	3.15584950
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.08810088
46	heme transport (GO:0015886)	3.06467225
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06460637
48	cell proliferation in forebrain (GO:0021846)	3.01017645
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99676353
50	NADH dehydrogenase complex assembly (GO:0010257)	2.99676353
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99676353
52	endoderm formation (GO:0001706)	2.98981016
53	GTP biosynthetic process (GO:0006183)	2.98681533
54	nonmotile primary cilium assembly (GO:0035058)	2.97531179
55	cilium morphogenesis (GO:0060271)	2.97289836
56	iron coordination entity transport (GO:1901678)	2.90715703
57	pyrimidine nucleotide catabolic process (GO:0006244)	2.89297306
58	regulation of microtubule-based movement (GO:0060632)	2.88585208
59	negative regulation of appetite (GO:0032099)	2.84727070
60	negative regulation of response to food (GO:0032096)	2.84727070
61	DNA dealkylation (GO:0035510)	2.84488677
62	chromatin remodeling at centromere (GO:0031055)	2.79522374
63	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.77294971
64	oxidative demethylation (GO:0070989)	2.77082662
65	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.73372070
66	relaxation of cardiac muscle (GO:0055119)	2.72766550
67	ubiquinone metabolic process (GO:0006743)	2.72037230
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.71288984
69	ATP biosynthetic process (GO:0006754)	2.70541319
70	positive regulation of protein homodimerization activity (GO:0090073)	2.70119182
71	piRNA metabolic process (GO:0034587)	2.67398025
72	hydrogen ion transmembrane transport (GO:1902600)	2.66633253
73	regulation of heart rate by cardiac conduction (GO:0086091)	2.64237198
74	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.63745552
75	telencephalon development (GO:0021537)	2.62024052
76	ubiquinone biosynthetic process (GO:0006744)	2.59485525
77	anterograde synaptic vesicle transport (GO:0048490)	2.54843868
78	pyrimidine-containing compound catabolic process (GO:0072529)	2.54065723
79	left/right pattern formation (GO:0060972)	2.53906729
80	protein K6-linked ubiquitination (GO:0085020)	2.52601011
81	response to redox state (GO:0051775)	2.52578697
82	termination of RNA polymerase III transcription (GO:0006386)	2.50320667
83	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50320667
84	keratinocyte development (GO:0003334)	2.48466745
85	DNA modification (GO:0006304)	2.48028351
86	CENP-A containing nucleosome assembly (GO:0034080)	2.47914676
87	short-term memory (GO:0007614)	2.46064175
88	regulation of mesoderm development (GO:2000380)	2.44295760
89	DNA methylation involved in gamete generation (GO:0043046)	2.42788382
90	proton transport (GO:0015992)	2.41167643
91	meiotic chromosome segregation (GO:0045132)	2.39718001
92	detection of light stimulus involved in sensory perception (GO:0050962)	2.38150808
93	detection of light stimulus involved in visual perception (GO:0050908)	2.38150808
94	synaptic transmission, cholinergic (GO:0007271)	2.37614287
95	negative regulation of organelle assembly (GO:1902116)	2.37378032
96	DNA double-strand break processing (GO:0000729)	2.35832071
97	hydrogen transport (GO:0006818)	2.35468066
98	organelle disassembly (GO:1903008)	2.34624988
99	regulation of sodium ion transmembrane transporter activity (GO:2000649)	2.34422253
100	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.32125254

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.50315021
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.53716732
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18593980
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.82248311
5	VDR_22108803_ChIP-Seq_LS180_Human	2.66433292
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.62780189
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.61269946
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.51121626
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44660707
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.20789590
11	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.16761918
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.12243525
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09397493
14	TP53_22573176_ChIP-Seq_HFKS_Human	1.84438339
15	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.80130743
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77341574
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75156257
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65086885
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.64326594
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61403566
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60217627
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57031145
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57031145
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56280771
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55935986
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.54609597
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51354142
28	P300_19829295_ChIP-Seq_ESCs_Human	1.51003677
29	HTT_18923047_ChIP-ChIP_STHdh_Human	1.50349393
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49974216
31	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48763892
32	EWS_26573619_Chip-Seq_HEK293_Human	1.48309045
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.43045188
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.43018471
35	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.42942774
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.41872438
37	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.41614521
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40002257
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40002257
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39353233
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38172585
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.38114376
43	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.37919528
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.37852395
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37158630
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36552087
47	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.34913270
48	NCOR_22424771_ChIP-Seq_293T_Human	1.34637033
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32830549
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29690497
51	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.27429412
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27011979
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25406344
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25406344
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24452863
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24433890
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23893854
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20274441
59	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20174494
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.18925232
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17112467
62	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16714842
63	AR_20517297_ChIP-Seq_VCAP_Human	1.16676397
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16332945
65	GBX2_23144817_ChIP-Seq_PC3_Human	1.15090948
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.13828216
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13828216
68	FUS_26573619_Chip-Seq_HEK293_Human	1.11683481
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11101359
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10768988
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10597951
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10475666
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09755133
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09435513
75	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.08000458
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07928419
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07897438
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07168284
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07076891
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05615328
81	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05470325
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04474869
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03712812
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03539135
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.03369576
86	ER_23166858_ChIP-Seq_MCF-7_Human	1.02642958
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00471352
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98447481
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97732389
90	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97461902
91	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.96273923
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94212843
93	ERA_21632823_ChIP-Seq_H3396_Human	0.92670424
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92628039
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.91275574
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90459831
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90223750
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.88192960
99	P53_21459846_ChIP-Seq_SAOS-2_Human	0.87746848
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87581173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.44046788
2	MP0003122_maternal_imprinting	2.56372757
3	MP0008877_abnormal_DNA_methylation	2.56122918
4	MP0008995_early_reproductive_senescence	2.47036853
5	MP0000372_irregular_coat_pigmentation	2.44130860
6	MP0002102_abnormal_ear_morphology	2.31557596
7	MP0008872_abnormal_physiological_respon	2.26121697
8	MP0005423_abnormal_somatic_nervous	2.22372998
9	MP0004885_abnormal_endolymph	2.20356582
10	MP0003880_abnormal_central_pattern	2.19249496
11	MP0001293_anophthalmia	2.17069940
12	MP0005377_hearing/vestibular/ear_phenot	2.13820860
13	MP0003878_abnormal_ear_physiology	2.13820860
14	MP0005084_abnormal_gallbladder_morpholo	2.11480336
15	MP0003123_paternal_imprinting	2.06353022
16	MP0008789_abnormal_olfactory_epithelium	2.06061091
17	MP0001984_abnormal_olfaction	2.02619758
18	MP0001485_abnormal_pinna_reflex	2.00227505
19	MP0002736_abnormal_nociception_after	1.91992334
20	MP0009379_abnormal_foot_pigmentation	1.85047490
21	MP0003646_muscle_fatigue	1.81122138
22	MP0003121_genomic_imprinting	1.78593677
23	MP0003787_abnormal_imprinting	1.75826835
24	MP0005253_abnormal_eye_physiology	1.74950345
25	MP0005394_taste/olfaction_phenotype	1.73272375
26	MP0005499_abnormal_olfactory_system	1.73272375
27	MP0005083_abnormal_biliary_tract	1.69265549
28	MP0002653_abnormal_ependyma_morphology	1.62009246
29	MP0002938_white_spotting	1.60489410
30	MP0008004_abnormal_stomach_pH	1.59625929
31	MP0005551_abnormal_eye_electrophysiolog	1.59209342
32	MP0006072_abnormal_retinal_apoptosis	1.53054731
33	MP0004133_heterotaxia	1.50993876
34	MP0005075_abnormal_melanosome_morpholog	1.48465707
35	MP0002163_abnormal_gland_morphology	1.46363224
36	MP0003786_premature_aging	1.44730890
37	MP0006054_spinal_hemorrhage	1.38525433
38	MP0003937_abnormal_limbs/digits/tail_de	1.35955550
39	MP0010030_abnormal_orbit_morphology	1.35309075
40	MP0004145_abnormal_muscle_electrophysio	1.35197860
41	MP0001968_abnormal_touch/_nociception	1.30704392
42	MP0003567_abnormal_fetal_cardiomyocyte	1.29757209
43	MP0004142_abnormal_muscle_tone	1.29265834
44	MP0000566_synostosis	1.28932614
45	MP0004484_altered_response_of	1.26852847
46	MP0001440_abnormal_grooming_behavior	1.26227966
47	MP0009046_muscle_twitch	1.24542052
48	MP0000778_abnormal_nervous_system	1.21516837
49	MP0003718_maternal_effect	1.21232423
50	MP0005391_vision/eye_phenotype	1.15097975
51	MP0002909_abnormal_adrenal_gland	1.14683930
52	MP0005646_abnormal_pituitary_gland	1.14246381
53	MP0005671_abnormal_response_to	1.13798482
54	MP0000631_abnormal_neuroendocrine_gland	1.12785378
55	MP0003136_yellow_coat_color	1.12484933
56	MP0001324_abnormal_eye_pigmentation	1.11963186
57	MP0006276_abnormal_autonomic_nervous	1.11387706
58	MP0004130_abnormal_muscle_cell	1.10919481
59	MP0000049_abnormal_middle_ear	1.10516229
60	MP0003806_abnormal_nucleotide_metabolis	1.08853382
61	MP0002557_abnormal_social/conspecific_i	1.07261535
62	MP0002272_abnormal_nervous_system	1.06869604
63	MP0005195_abnormal_posterior_eye	1.06566414
64	MP0005408_hypopigmentation	1.05657490
65	MP0002733_abnormal_thermal_nociception	1.04882386
66	MP0009745_abnormal_behavioral_response	1.03716029
67	MP0008775_abnormal_heart_ventricle	1.03100709
68	MP0003195_calcinosis	1.02424093
69	MP0001486_abnormal_startle_reflex	1.02308683
70	MP0002095_abnormal_skin_pigmentation	1.01856762
71	MP0004147_increased_porphyrin_level	1.01671984
72	MP0000230_abnormal_systemic_arterial	0.99606877
73	MP0001970_abnormal_pain_threshold	0.98201542
74	MP0001529_abnormal_vocalization	0.97780200
75	MP0003186_abnormal_redox_activity	0.97450722
76	MP0002572_abnormal_emotion/affect_behav	0.96969454
77	MP0000026_abnormal_inner_ear	0.95626230
78	MP0004043_abnormal_pH_regulation	0.93803675
79	MP0005645_abnormal_hypothalamus_physiol	0.92800185
80	MP0003119_abnormal_digestive_system	0.92450679
81	MP0005379_endocrine/exocrine_gland_phen	0.91384876
82	MP0002752_abnormal_somatic_nervous	0.90784346
83	MP0002233_abnormal_nose_morphology	0.90711369
84	MP0001348_abnormal_lacrimal_gland	0.89586250
85	MP0001502_abnormal_circadian_rhythm	0.88160964
86	MP0001286_abnormal_eye_development	0.88150569
87	MP0008875_abnormal_xenobiotic_pharmacok	0.83885781
88	MP0001905_abnormal_dopamine_level	0.83582200
89	MP0001963_abnormal_hearing_physiology	0.82880789
90	MP0002837_dystrophic_cardiac_calcinosis	0.81993936
91	MP0000427_abnormal_hair_cycle	0.81406937
92	MP0003890_abnormal_embryonic-extraembry	0.80322677
93	MP0002876_abnormal_thyroid_physiology	0.80194880
94	MP0002160_abnormal_reproductive_system	0.80031908
95	MP0002210_abnormal_sex_determination	0.77836074
96	MP0000647_abnormal_sebaceous_gland	0.77597283
97	MP0002067_abnormal_sensory_capabilities	0.76200523
98	MP0003137_abnormal_impulse_conducting	0.73534431
99	MP0005636_abnormal_mineral_homeostasis	0.73099072
100	MP0004742_abnormal_vestibular_system	0.72716321

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.92859369
2	Molar tooth sign on MRI (HP:0002419)	4.92859369
3	Pancreatic cysts (HP:0001737)	3.69346069
4	Acute necrotizing encephalopathy (HP:0006965)	3.65501868
5	Acute encephalopathy (HP:0006846)	3.60221670
6	Bifid tongue (HP:0010297)	3.58187462
7	Abnormal ciliary motility (HP:0012262)	3.53880160
8	Absent/shortened dynein arms (HP:0200106)	3.35447581
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.35447581
10	Pancreatic fibrosis (HP:0100732)	3.33969240
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.29042996
12	Mitochondrial inheritance (HP:0001427)	3.24217997
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.17967222
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.14564793
15	Progressive macrocephaly (HP:0004481)	3.10021667
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07657222
17	Abnormal respiratory motile cilium morphology (HP:0005938)	2.99737517
18	Abnormal respiratory epithelium morphology (HP:0012253)	2.99737517
19	Increased CSF lactate (HP:0002490)	2.89316528
20	True hermaphroditism (HP:0010459)	2.85002380
21	Hepatocellular necrosis (HP:0001404)	2.79585871
22	Medial flaring of the eyebrow (HP:0010747)	2.76377498
23	Polyphagia (HP:0002591)	2.66316871
24	Postaxial foot polydactyly (HP:0001830)	2.63798062
25	Supernumerary spleens (HP:0009799)	2.61946300
26	Nephronophthisis (HP:0000090)	2.53965073
27	Anencephaly (HP:0002323)	2.52395180
28	Sclerocornea (HP:0000647)	2.50682885
29	Cystic liver disease (HP:0006706)	2.40257249
30	Tubulointerstitial nephritis (HP:0001970)	2.39373895
31	Short tibia (HP:0005736)	2.37305712
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.35497452
33	Hepatic necrosis (HP:0002605)	2.31912937
34	Myokymia (HP:0002411)	2.30940539
35	Abnormality of the labia minora (HP:0012880)	2.29999563
36	3-Methylglutaconic aciduria (HP:0003535)	2.28550018
37	Abnormality of the renal medulla (HP:0100957)	2.28034475
38	Renal cortical cysts (HP:0000803)	2.24745157
39	Increased hepatocellular lipid droplets (HP:0006565)	2.22135363
40	Reticulocytopenia (HP:0001896)	2.20241445
41	Chronic bronchitis (HP:0004469)	2.19789116
42	Preaxial hand polydactyly (HP:0001177)	2.18646647
43	Hyperglycinemia (HP:0002154)	2.18080950
44	Congenital stationary night blindness (HP:0007642)	2.17931083
45	Optic disc pallor (HP:0000543)	2.15664849
46	Absent thumb (HP:0009777)	2.12677204
47	Thyroid-stimulating hormone excess (HP:0002925)	2.11991424
48	Decreased central vision (HP:0007663)	2.10621211
49	Dyschromatopsia (HP:0007641)	2.10171994
50	Gait imbalance (HP:0002141)	2.10105332
51	Colon cancer (HP:0003003)	2.07517983
52	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06733669
53	Hypoplasia of the pons (HP:0012110)	2.06119842
54	Median cleft lip (HP:0000161)	2.05687874
55	Pendular nystagmus (HP:0012043)	2.03098682
56	Broad alveolar ridges (HP:0000187)	2.02772354
57	Postaxial hand polydactyly (HP:0001162)	2.01345992
58	Rectal fistula (HP:0100590)	2.00566790
59	Rectovaginal fistula (HP:0000143)	2.00566790
60	Cerebral edema (HP:0002181)	1.99604967
61	Microretrognathia (HP:0000308)	1.94372793
62	Abnormality of the renal cortex (HP:0011035)	1.92139435
63	Broad-based gait (HP:0002136)	1.91747187
64	Renal Fanconi syndrome (HP:0001994)	1.91659999
65	Anophthalmia (HP:0000528)	1.91008513
66	Ectopic kidney (HP:0000086)	1.88917061
67	Lipid accumulation in hepatocytes (HP:0006561)	1.88503838
68	Increased serum lactate (HP:0002151)	1.88058244
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87661050
70	Narrow forehead (HP:0000341)	1.87173094
71	Rib fusion (HP:0000902)	1.87170592
72	Rhinitis (HP:0012384)	1.84052829
73	Congenital primary aphakia (HP:0007707)	1.83544880
74	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.82705354
75	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.82705354
76	Lissencephaly (HP:0001339)	1.82304159
77	Septo-optic dysplasia (HP:0100842)	1.81814681
78	Abolished electroretinogram (ERG) (HP:0000550)	1.78502985
79	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78128291
80	Pachygyria (HP:0001302)	1.77584006
81	Oculomotor apraxia (HP:0000657)	1.76608405
82	Congenital hepatic fibrosis (HP:0002612)	1.74874267
83	Hypomagnesemia (HP:0002917)	1.74295588
84	Lactic acidosis (HP:0003128)	1.73121027
85	Abnormality of renal resorption (HP:0011038)	1.71678257
86	Abnormality of magnesium homeostasis (HP:0004921)	1.70122600
87	Abnormality of the pons (HP:0007361)	1.70048793
88	Male pseudohermaphroditism (HP:0000037)	1.69210420
89	Nephrogenic diabetes insipidus (HP:0009806)	1.68939377
90	Abnormality of alanine metabolism (HP:0010916)	1.67873789
91	Hyperalaninemia (HP:0003348)	1.67873789
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67873789
93	Diastasis recti (HP:0001540)	1.67858355
94	Large eyes (HP:0001090)	1.67346397
95	Adrenal hypoplasia (HP:0000835)	1.65072185
96	Pigmentary retinal degeneration (HP:0001146)	1.64480793
97	Respiratory failure (HP:0002878)	1.62391761
98	Amyotrophic lateral sclerosis (HP:0007354)	1.62192690
99	Genital tract atresia (HP:0001827)	1.61620350
100	Occipital encephalocele (HP:0002085)	1.61436360

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.22795402
2	TXK	3.58235397
3	WNK4	3.50606167
4	TRIM28	2.81073052
5	CDK19	2.61036221
6	OXSR1	2.42718314
7	ADRBK2	2.40069604
8	TAOK3	2.37255495
9	BMPR1B	2.36767633
10	FRK	2.16726832
11	STK39	2.14674019
12	PINK1	2.08548876
13	ZAK	1.99288247
14	GRK1	1.88322914
15	WNK3	1.66415343
16	SIK3	1.65889595
17	NUAK1	1.59968123
18	PNCK	1.56360559
19	BRSK2	1.49755285
20	MARK1	1.43948847
21	MAP2K7	1.42206715
22	CAMKK2	1.41338745
23	GRK7	1.40230489
24	PLK3	1.38990977
25	PRKD3	1.37437987
26	BCR	1.34668682
27	BCKDK	1.30891411
28	MAPK13	1.30458488
29	MINK1	1.25976359
30	KDR	1.22381147
31	PLK2	1.19220028
32	DYRK2	1.18663188
33	TIE1	1.16431696
34	MAP2K6	1.12944433
35	WEE1	1.07446711
36	VRK2	1.04773046
37	VRK1	1.02554804
38	CAMK2D	1.00152113
39	EPHB2	0.98798145
40	SRPK1	0.93691810
41	PRKCG	0.91903125
42	STK16	0.91351190
43	MAP3K4	0.88822232
44	TNIK	0.84484798
45	GRK5	0.78499731
46	CDK8	0.78342444
47	CDC7	0.77893937
48	MST4	0.76239913
49	PLK1	0.75027427
50	TAF1	0.71622703
51	PRKCI	0.70358449
52	FES	0.68529617
53	ACVR1B	0.67858212
54	BRSK1	0.65958046
55	NEK1	0.65837059
56	STK4	0.65371414
57	PHKG2	0.65027631
58	PHKG1	0.65027631
59	ADRBK1	0.64211854
60	AURKA	0.63626408
61	PLK4	0.63054868
62	NTRK2	0.62244125
63	MYLK	0.61449593
64	CAMK2A	0.59326549
65	PDK2	0.59311547
66	CSNK1G1	0.59309620
67	CSF1R	0.58949385
68	NEK9	0.58670773
69	TSSK6	0.58592840
70	WNK1	0.56425233
71	CAMK1	0.55796904
72	CASK	0.54977638
73	LIMK1	0.54960089
74	DYRK1A	0.54540963
75	TEC	0.53783294
76	MKNK2	0.53314487
77	ATR	0.52676459
78	PRKCE	0.51180689
79	PRKCQ	0.50892865
80	NME1	0.50443952
81	TLK1	0.49196080
82	TGFBR1	0.48947402
83	PRKACA	0.48269181
84	STK3	0.48241553
85	SYK	0.47522650
86	MAP4K1	0.45688804
87	MARK2	0.45659391
88	NEK2	0.45358335
89	PTK2B	0.43282884
90	CSNK1E	0.43218622
91	CSNK1G2	0.42775902
92	ROCK1	0.42723505
93	LRRK2	0.42084235
94	OBSCN	0.42077928
95	INSRR	0.41912308
96	PAK3	0.39744355
97	PRKCA	0.38649869
98	BTK	0.38474748
99	TNK2	0.37044074
100	PRKCD	0.35171567

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.97851876
2	Proteasome_Homo sapiens_hsa03050	3.40333389
3	Parkinsons disease_Homo sapiens_hsa05012	3.11382275
4	Protein export_Homo sapiens_hsa03060	2.79513292
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.49733374
6	Ribosome_Homo sapiens_hsa03010	2.42864410
7	RNA polymerase_Homo sapiens_hsa03020	2.37280678
8	Alzheimers disease_Homo sapiens_hsa05010	2.36312687
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.29246770
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.25168147
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.23780034
12	Huntingtons disease_Homo sapiens_hsa05016	2.17008234
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.13221986
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99438261
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.98555645
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.95349632
17	Basal transcription factors_Homo sapiens_hsa03022	1.87557894
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83211643
19	Homologous recombination_Homo sapiens_hsa03440	1.70988724
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.70958567
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68985849
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.66157719
23	Phototransduction_Homo sapiens_hsa04744	1.65585445
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59625505
25	Peroxisome_Homo sapiens_hsa04146	1.51739105
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.43321051
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.35578391
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34417111
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32885570
30	RNA degradation_Homo sapiens_hsa03018	1.27661687
31	One carbon pool by folate_Homo sapiens_hsa00670	1.24815312
32	Propanoate metabolism_Homo sapiens_hsa00640	1.23796355
33	Olfactory transduction_Homo sapiens_hsa04740	1.14160329
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13179739
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.03985439
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.02144382
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.01300901
38	Butanoate metabolism_Homo sapiens_hsa00650	0.99091302
39	Folate biosynthesis_Homo sapiens_hsa00790	0.98038153
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97616144
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95292746
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.94191866
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93559137
44	Purine metabolism_Homo sapiens_hsa00230	0.92808294
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91593490
46	Caffeine metabolism_Homo sapiens_hsa00232	0.90460687
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.88394602
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.85909697
49	Nicotine addiction_Homo sapiens_hsa05033	0.85815401
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82412202
51	Mismatch repair_Homo sapiens_hsa03430	0.78677491
52	Insulin secretion_Homo sapiens_hsa04911	0.75250405
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74823420
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72838855
55	Retinol metabolism_Homo sapiens_hsa00830	0.72412174
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66391250
57	Metabolic pathways_Homo sapiens_hsa01100	0.66169328
58	Salivary secretion_Homo sapiens_hsa04970	0.65534611
59	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63286812
60	Gastric acid secretion_Homo sapiens_hsa04971	0.63270513
61	Fatty acid degradation_Homo sapiens_hsa00071	0.63111454
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62178879
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61283092
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58762441
65	Circadian entrainment_Homo sapiens_hsa04713	0.58758625
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57960167
67	Oocyte meiosis_Homo sapiens_hsa04114	0.57644266
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57077429
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56824660
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.53614079
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51568978
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51019226
73	Amphetamine addiction_Homo sapiens_hsa05031	0.49060997
74	Fatty acid elongation_Homo sapiens_hsa00062	0.48503869
75	Serotonergic synapse_Homo sapiens_hsa04726	0.47252914
76	Taste transduction_Homo sapiens_hsa04742	0.46952644
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46223639
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.46109592
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.45442144
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45024086
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.43653187
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41472947
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.40264297
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39368525
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.38351221
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37087480
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35684373
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35536090
89	RNA transport_Homo sapiens_hsa03013	0.33850538
90	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.31966900
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31218026
92	Morphine addiction_Homo sapiens_hsa05032	0.29057501
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.27689457
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.27663794
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27113329
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.26423215
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.25716975
98	Pancreatic secretion_Homo sapiens_hsa04972	0.25142302
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.24787127
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24427658

HMGB1P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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