HMGB1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.20279831
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.90762220
3cytidine catabolic process (GO:0006216)4.42044489
4cytidine deamination (GO:0009972)4.42044489
5cytidine metabolic process (GO:0046087)4.42044489
6negative regulation of cell killing (GO:0031342)4.24722889
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24722889
8kidney morphogenesis (GO:0060993)4.19207447
9respiratory tube development (GO:0030323)4.09974006
10positive regulation of alpha-beta T cell proliferation (GO:0046641)4.02010229
11regulation of B cell receptor signaling pathway (GO:0050855)4.00478945
12negative T cell selection (GO:0043383)3.95232936
13regulation of memory T cell differentiation (GO:0043380)3.86600659
14cellular response to interleukin-15 (GO:0071350)3.84407271
15pyrimidine ribonucleoside catabolic process (GO:0046133)3.83139445
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77483308
17response to interferon-beta (GO:0035456)3.77279909
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74086015
19regulation of alpha-beta T cell proliferation (GO:0046640)3.73668537
20positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.62532994
21positive regulation of defense response to virus by host (GO:0002230)3.51099746
22mast cell activation (GO:0045576)3.44467733
23base-excision repair, AP site formation (GO:0006285)3.40091446
24negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39422750
25negative regulation of T-helper cell differentiation (GO:0045623)3.39422750
26cellular extravasation (GO:0045123)3.38535927
27cellular response to interferon-beta (GO:0035458)3.38308562
28regulation of hypersensitivity (GO:0002883)3.36387016
29positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33742413
30regulation of regulatory T cell differentiation (GO:0045589)3.32710977
31positive regulation of gamma-delta T cell activation (GO:0046645)3.28987370
32negative regulation of T cell mediated immunity (GO:0002710)3.28672045
33negative thymic T cell selection (GO:0045060)3.25016414
34microglial cell activation (GO:0001774)3.23631666
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19121551
36response to interleukin-15 (GO:0070672)3.17737452
37cartilage morphogenesis (GO:0060536)3.17552493
38lung epithelium development (GO:0060428)3.16627276
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16384062
40myeloid leukocyte mediated immunity (GO:0002444)3.15118239
41neutrophil mediated immunity (GO:0002446)3.13927061
42preassembly of GPI anchor in ER membrane (GO:0016254)3.13269426
43regulation of T-helper 1 type immune response (GO:0002825)3.12709899
44positive regulation of B cell mediated immunity (GO:0002714)3.11757106
45positive regulation of immunoglobulin mediated immune response (GO:0002891)3.11757106
46positive T cell selection (GO:0043368)3.11577583
47metanephric tubule development (GO:0072170)3.10159892
48metanephric nephron tubule development (GO:0072234)3.10159892
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10041329
50mast cell activation involved in immune response (GO:0002279)3.09820621
51mast cell degranulation (GO:0043303)3.09820621
52immunoglobulin mediated immune response (GO:0016064)3.09814186
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07879268
54regulation of T-helper 1 cell differentiation (GO:0045625)3.02311746
55negative regulation of growth of symbiont in host (GO:0044130)3.02095364
56negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.02095364
57modulation of growth of symbiont involved in interaction with host (GO:0044144)3.02095364
58regulation of growth of symbiont in host (GO:0044126)3.02095364
59negative regulation of interleukin-12 production (GO:0032695)3.00391519
60regulation of T cell receptor signaling pathway (GO:0050856)2.99066820
61regulation of T cell mediated cytotoxicity (GO:0001914)2.96094333
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95559224
63B cell mediated immunity (GO:0019724)2.91207944
64negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87523625
65regulation of germinal center formation (GO:0002634)2.86187129
66positive thymic T cell selection (GO:0045059)2.83434251
67positive regulation of DNA recombination (GO:0045911)2.81059774
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80162256
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77818718
70positive regulation of T cell differentiation in thymus (GO:0033089)2.74530663
71negative regulation of viral genome replication (GO:0045071)2.74460460
72positive regulation of isotype switching (GO:0045830)2.69755751
73antigen processing and presentation of endogenous antigen (GO:0019883)2.69724702
74metanephric nephron epithelium development (GO:0072243)2.69568361
75regulation of B cell differentiation (GO:0045577)2.69355493
76positive regulation of T-helper 1 type immune response (GO:0002827)2.68547437
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66333555
78regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.64539981
79negative regulation of adaptive immune response (GO:0002820)2.64176854
80interferon-gamma production (GO:0032609)2.60379358
81pyrimidine nucleotide catabolic process (GO:0006244)2.59258297
82DNA demethylation (GO:0080111)2.57230228
83regulation of isotype switching to IgG isotypes (GO:0048302)2.57177305
84negative regulation of alpha-beta T cell differentiation (GO:0046639)2.56901134
85regulation of immunoglobulin secretion (GO:0051023)2.55420553
86deoxyribonucleotide catabolic process (GO:0009264)2.55388560
87negative regulation of alpha-beta T cell activation (GO:0046636)2.55130768
88T cell migration (GO:0072678)2.54983221
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52819703
90regulation of chemokine biosynthetic process (GO:0045073)2.51599638
91regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.50087239
92negative regulation of mast cell activation (GO:0033004)2.49908264
93deoxyribose phosphate catabolic process (GO:0046386)2.49822044
94positive regulation of interleukin-17 production (GO:0032740)2.49146671
95neutrophil activation involved in immune response (GO:0002283)2.48484842
96positive regulation of cell fate commitment (GO:0010455)2.48231459
97regulation of B cell mediated immunity (GO:0002712)2.47282774
98metanephric epithelium development (GO:0072207)2.47228928
99antigen processing and presentation via MHC class Ib (GO:0002475)2.45041023
100DNA dealkylation (GO:0035510)2.44388530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.13692235
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.21858429
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02649842
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.87670216
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.56404647
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.30697193
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27818820
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.14658112
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01032902
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.80449785
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41876498
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28671942
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.24509726
14MYB_26560356_Chip-Seq_TH2_Human2.18471384
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15149070
16VDR_23849224_ChIP-Seq_CD4+_Human2.01160992
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97917595
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.95692247
19GATA3_26560356_Chip-Seq_TH2_Human1.93879868
20SPI1_23547873_ChIP-Seq_NB4_Human1.90665105
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89624082
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89023356
23FOXP3_21729870_ChIP-Seq_TREG_Human1.88994282
24RUNX_20019798_ChIP-Seq_JUKART_Human1.87785170
25VDR_22108803_ChIP-Seq_LS180_Human1.84641040
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84320059
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84112992
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.75449341
29GATA3_27048872_Chip-Seq_THYMUS_Human1.74276069
30ZNF274_21170338_ChIP-Seq_K562_Hela1.72147823
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71499892
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71014954
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.70932667
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64911616
35SCL_19346495_ChIP-Seq_HPC-7_Human1.62542019
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.62229047
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61196244
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57753872
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.55652238
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44887453
41MYB_26560356_Chip-Seq_TH1_Human1.44228625
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44153398
43ELK1_19687146_ChIP-ChIP_HELA_Human1.43716937
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41550418
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37445824
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37211118
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.25945741
48EWS_26573619_Chip-Seq_HEK293_Human1.25027695
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22053090
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20900868
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18221771
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17932894
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17597749
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.17597749
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15993132
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10615761
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09844950
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08190546
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07473291
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06328747
61CBP_20019798_ChIP-Seq_JUKART_Human1.06328747
62TAF15_26573619_Chip-Seq_HEK293_Human1.06261512
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06260016
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05527195
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04664242
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03703254
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02673821
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00004949
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99133130
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98873959
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98609954
72ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98229051
73MYC_18940864_ChIP-ChIP_HL60_Human0.98089399
74PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97835262
75AR_20517297_ChIP-Seq_VCAP_Human0.96984062
76TP53_22573176_ChIP-Seq_HFKS_Human0.96331584
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95855819
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94714841
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.94272867
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93390448
81VDR_24787735_ChIP-Seq_THP-1_Human0.93110865
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93040117
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.92743713
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92653488
85GATA3_26560356_Chip-Seq_TH1_Human0.92615906
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91344681
87UTX_26944678_Chip-Seq_JUKART_Human0.90930805
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.90758944
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90721640
90STAT1_20625510_ChIP-Seq_HELA_Human0.90338428
91ER_23166858_ChIP-Seq_MCF-7_Human0.89907112
92SMRT_27268052_Chip-Seq_Bcells_Human0.89245965
93HOXB7_26014856_ChIP-Seq_BT474_Human0.88878115
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.87182664
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87148717
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85910996
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85078533
98SOX2_19829295_ChIP-Seq_ESCs_Human0.84896826
99NANOG_19829295_ChIP-Seq_ESCs_Human0.84896826
100MAF_26560356_Chip-Seq_TH2_Human0.84576961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.47241161
2MP0001835_abnormal_antigen_presentation3.87576152
3MP0009785_altered_susceptibility_to2.99463634
4MP0002148_abnormal_hypersensitivity_rea2.99417076
5MP0003724_increased_susceptibility_to2.87732422
6MP0001800_abnormal_humoral_immune2.80340939
7MP0005000_abnormal_immune_tolerance2.69848243
8MP0000685_abnormal_immune_system2.57319728
9MP0003763_abnormal_thymus_physiology2.56951176
10MP0008057_abnormal_DNA_replication2.48732932
11MP0002723_abnormal_immune_serum2.46773732
12MP0009278_abnormal_bone_marrow2.43713893
13MP0000569_abnormal_digit_pigmentation2.35770780
14MP0003436_decreased_susceptibility_to2.31576720
15MP0005025_abnormal_response_to2.30898820
16MP0002452_abnormal_antigen_presenting2.25901815
17MP0002420_abnormal_adaptive_immunity2.23867391
18MP0001819_abnormal_immune_cell2.22806033
19MP0005646_abnormal_pituitary_gland2.17734727
20MP0002166_altered_tumor_susceptibility2.16592282
21MP0008877_abnormal_DNA_methylation2.12070802
22MP0002102_abnormal_ear_morphology2.11463969
23MP0002419_abnormal_innate_immunity2.06641814
24MP0001790_abnormal_immune_system2.05260776
25MP0005387_immune_system_phenotype2.05260776
26MP0002653_abnormal_ependyma_morphology1.96289080
27MP0005174_abnormal_tail_pigmentation1.94391546
28MP0002398_abnormal_bone_marrow1.87228931
29MP0009764_decreased_sensitivity_to1.86068535
30MP0002006_tumorigenesis1.84588004
31MP0003191_abnormal_cellular_cholesterol1.82916573
32MP0000015_abnormal_ear_pigmentation1.81063463
33MP0006054_spinal_hemorrhage1.75635934
34MP0000716_abnormal_immune_system1.74514406
35MP0005464_abnormal_platelet_physiology1.71341569
36MP0001346_abnormal_lacrimal_gland1.70020642
37MP0001845_abnormal_inflammatory_respons1.58420701
38MP0002405_respiratory_system_inflammati1.55637688
39MP0000689_abnormal_spleen_morphology1.51684091
40MP0006082_CNS_inflammation1.49356880
41MP0003806_abnormal_nucleotide_metabolis1.46379446
42MP0001545_abnormal_hematopoietic_system1.46137430
43MP0005397_hematopoietic_system_phenotyp1.46137430
44MP0004381_abnormal_hair_follicle1.44340614
45MP0002429_abnormal_blood_cell1.44202665
46MP0009840_abnormal_foam_cell1.38308438
47MP0003786_premature_aging1.36781355
48MP0005075_abnormal_melanosome_morpholog1.33800858
49MP0010094_abnormal_chromosome_stability1.33326214
50MP0001533_abnormal_skeleton_physiology1.33100115
51MP0002722_abnormal_immune_system1.31109184
52MP0002277_abnormal_respiratory_mucosa1.27581633
53MP0002095_abnormal_skin_pigmentation1.25937855
54MP0009333_abnormal_splenocyte_physiolog1.22908579
55MP0002876_abnormal_thyroid_physiology1.20160551
56MP0001853_heart_inflammation1.20120654
57MP0003195_calcinosis1.19000839
58MP0000703_abnormal_thymus_morphology1.16116411
59MP0008469_abnormal_protein_level1.15049266
60MP0004947_skin_inflammation1.13440508
61MP0003252_abnormal_bile_duct1.09168481
62MP0003787_abnormal_imprinting1.08096155
63MP0003950_abnormal_plasma_membrane1.08007474
64MP0003866_abnormal_defecation1.05003074
65MP0009763_increased_sensitivity_to1.04709703
66MP0008058_abnormal_DNA_repair0.96766401
67MP0005084_abnormal_gallbladder_morpholo0.95135691
68MP0005310_abnormal_salivary_gland0.94483556
69MP0008872_abnormal_physiological_respon0.92997653
70MP0000427_abnormal_hair_cycle0.89192654
71MP0010155_abnormal_intestine_physiology0.89122462
72MP0003303_peritoneal_inflammation0.87528994
73MP0001663_abnormal_digestive_system0.85869333
74MP0006036_abnormal_mitochondrial_physio0.85457293
75MP0002163_abnormal_gland_morphology0.84297661
76MP0008789_abnormal_olfactory_epithelium0.83489337
77MP0004885_abnormal_endolymph0.82566135
78MP0003656_abnormal_erythrocyte_physiolo0.82132796
79MP0006072_abnormal_retinal_apoptosis0.81281910
80MP0001986_abnormal_taste_sensitivity0.80567742
81MP0000372_irregular_coat_pigmentation0.79640056
82MP0005164_abnormal_response_to0.79332509
83MP0002019_abnormal_tumor_incidence0.78973063
84MP0009765_abnormal_xenobiotic_induced0.76705617
85MP0005551_abnormal_eye_electrophysiolog0.76657684
86MP0005058_abnormal_lysosome_morphology0.76269878
87MP0001501_abnormal_sleep_pattern0.75030986
88MP0008875_abnormal_xenobiotic_pharmacok0.74224970
89MP0005248_abnormal_Harderian_gland0.71542674
90MP0000465_gastrointestinal_hemorrhage0.71529496
91MP0000343_altered_response_to0.69340247
92MP0001119_abnormal_female_reproductive0.69139665
93MP0009379_abnormal_foot_pigmentation0.66700802
94MP0003186_abnormal_redox_activity0.65389030
95MP0008873_increased_physiological_sensi0.64954483
96MP0005410_abnormal_fertilization0.62428205
97MP0005167_abnormal_blood-brain_barrier0.61855873
98MP0005266_abnormal_metabolism0.61797005
99MP0002396_abnormal_hematopoietic_system0.61762559
100MP0002837_dystrophic_cardiac_calcinosis0.60976647

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.06486082
2T lymphocytopenia (HP:0005403)4.88652137
3Abnormality of T cell number (HP:0011839)4.53164882
4Stomatitis (HP:0010280)4.11314045
5IgG deficiency (HP:0004315)4.01258235
6Abnormality of eosinophils (HP:0001879)3.68866271
7Severe combined immunodeficiency (HP:0004430)3.62839245
8Eosinophilia (HP:0001880)3.52735772
9Abnormality of T cells (HP:0002843)3.45697277
10Retrobulbar optic neuritis (HP:0100654)3.29666476
11Optic neuritis (HP:0100653)3.29666476
12Thyroiditis (HP:0100646)3.21320961
13Decreased central vision (HP:0007663)3.11984142
14Abnormality of the prostate (HP:0008775)3.07375782
15B lymphocytopenia (HP:0010976)3.02640716
16Myositis (HP:0100614)2.99580716
17Abnormality of B cell number (HP:0010975)2.98982198
18Duplicated collecting system (HP:0000081)2.95658778
19Combined immunodeficiency (HP:0005387)2.94476618
20Orchitis (HP:0100796)2.94453972
21Panhypogammaglobulinemia (HP:0003139)2.93116214
22Autoimmune hemolytic anemia (HP:0001890)2.88033302
233-Methylglutaconic aciduria (HP:0003535)2.87136063
24Granulocytopenia (HP:0001913)2.86992953
25Leukocytosis (HP:0001974)2.84408872
26Recurrent bacterial skin infections (HP:0005406)2.81112158
27Abnormality of the renal collecting system (HP:0004742)2.80288565
28Recurrent fungal infections (HP:0002841)2.78816522
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73070016
30Pulmonary infiltrates (HP:0002113)2.60346047
31True hermaphroditism (HP:0010459)2.57682879
32Dyschromatopsia (HP:0007641)2.54576743
33Recurrent abscess formation (HP:0002722)2.53741946
34Vasculitis (HP:0002633)2.49066138
35Encephalitis (HP:0002383)2.47470148
36Abnormal rod and cone electroretinograms (HP:0008323)2.47420612
37Recurrent viral infections (HP:0004429)2.44965986
38Hypoplasia of the thymus (HP:0000778)2.44638318
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.44030240
40Recurrent cutaneous fungal infections (HP:0011370)2.43196903
41Chronic mucocutaneous candidiasis (HP:0002728)2.43196903
42Mediastinal lymphadenopathy (HP:0100721)2.40906319
43Abolished electroretinogram (ERG) (HP:0000550)2.39933078
44Increased IgM level (HP:0003496)2.36221014
45Nephronophthisis (HP:0000090)2.32990677
46Abnormality of T cell physiology (HP:0011840)2.32792370
47Meningitis (HP:0001287)2.32565215
48Hemoptysis (HP:0002105)2.31326045
49Chronic obstructive pulmonary disease (HP:0006510)2.30869333
50Obstructive lung disease (HP:0006536)2.30869333
51Congenital stationary night blindness (HP:0007642)2.30740617
52Recurrent bronchitis (HP:0002837)2.27736363
53Thrombocytosis (HP:0001894)2.25587503
54Abnormality of male internal genitalia (HP:0000022)2.24291660
55Abnormality of the pons (HP:0007361)2.23348108
56Pancreatic cysts (HP:0001737)2.22061130
57Mitochondrial inheritance (HP:0001427)2.21841622
58Hepatocellular necrosis (HP:0001404)2.21734498
59Gastrointestinal infarctions (HP:0005244)2.21063459
60Pancreatic fibrosis (HP:0100732)2.18494703
61Large for gestational age (HP:0001520)2.18202300
62Hypergammaglobulinemia (HP:0010702)2.16837476
63Medial flaring of the eyebrow (HP:0010747)2.15565603
64Aplastic anemia (HP:0001915)2.11924809
65Abnormality of alanine metabolism (HP:0010916)2.11923320
66Hyperalaninemia (HP:0003348)2.11923320
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11923320
68Lipid accumulation in hepatocytes (HP:0006561)2.10923464
69Hypoproteinemia (HP:0003075)2.09918178
70Recurrent skin infections (HP:0001581)2.09380490
71Renal cortical cysts (HP:0000803)2.08975077
72Prostate neoplasm (HP:0100787)2.07867205
73Attenuation of retinal blood vessels (HP:0007843)2.07598912
74Keratoconjunctivitis sicca (HP:0001097)2.07515042
75Abnormality of the pleura (HP:0002103)2.06825439
76Abnormality of midbrain morphology (HP:0002418)2.05840555
77Molar tooth sign on MRI (HP:0002419)2.05840555
78Increased CSF lactate (HP:0002490)2.04002884
79Methylmalonic acidemia (HP:0002912)2.02706020
80Abnormality of the renal cortex (HP:0011035)2.02671126
81Progressive microcephaly (HP:0000253)2.02644550
82Agammaglobulinemia (HP:0004432)2.00773979
83Arterial thrombosis (HP:0004420)2.00485063
84Gangrene (HP:0100758)2.00079753
85Neutropenia (HP:0001875)1.99823971
86Abnormality of the renal medulla (HP:0100957)1.99754177
87Keratoconjunctivitis (HP:0001096)1.99243552
88Vacuolated lymphocytes (HP:0001922)1.93178140
89Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90437689
90Pulmonary fibrosis (HP:0002206)1.89522103
91Chronic diarrhea (HP:0002028)1.89262445
92Hepatic necrosis (HP:0002605)1.89066636
93Chest pain (HP:0100749)1.88651433
94IgM deficiency (HP:0002850)1.87680185
95Papilledema (HP:0001085)1.87614955
96IgA deficiency (HP:0002720)1.84656242
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83213527
98Chronic otitis media (HP:0000389)1.82509888
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81431262
100Acute necrotizing encephalopathy (HP:0006965)1.81306559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.30769772
2TLK13.22280794
3TAOK33.14718535
4MAP4K12.78568573
5KIT2.70731646
6VRK22.25091126
7NUAK12.20563455
8IRAK42.19838734
9MAP3K142.11026943
10FRK2.08047436
11GRK62.07847777
12ZAK2.02326683
13MST41.85798509
14TEC1.85427940
15ADRBK21.84340342
16SYK1.83417304
17FES1.82445921
18IKBKB1.67042734
19RIPK41.63505085
20IKBKE1.62231672
21EIF2AK31.58533731
22GRK51.57341274
23GRK11.54894514
24BLK1.44246390
25BMPR21.43358385
26TYK21.42422825
27ITK1.42023388
28KDR1.38557339
29JAK11.37889204
30EIF2AK11.35298239
31VRK11.33020132
32MAP4K21.32948472
33JAK31.31609543
34LYN1.30514620
35GRK71.28100663
36PRKCQ1.24474267
37BCKDK1.23437486
38LCK1.20460190
39EIF2AK21.17087339
40TNK21.15677981
41TESK21.15551685
42MATK1.15220424
43BTK1.13509656
44ZAP701.11720350
45TBK11.10751541
46PTK2B1.06570500
47CSK1.06047193
48PIK3CG1.04677372
49DAPK21.02433084
50PINK10.98804461
51TRIM280.98477517
52MAP3K120.97668327
53CSF1R0.95188302
54HCK0.92001020
55CDC70.87493939
56OXSR10.86221081
57ADRBK10.85558345
58BCR0.84830023
59PIM20.81982775
60PIM10.81070270
61MAPKAPK30.80150605
62ATR0.78752374
63CAMKK20.75832431
64MAP2K60.70144039
65NME10.68568772
66RPS6KA50.68378947
67CLK10.67802367
68PLK20.66373095
69TGFBR20.66169707
70CHUK0.62474851
71PLK30.61346770
72MARK30.60050163
73BMPR1B0.56012635
74ACVR1B0.53724635
75IRAK10.53144506
76ABL10.52412517
77WNK30.52263672
78STK100.47740216
79AURKB0.46131240
80JAK20.43058338
81INSRR0.41357841
82CDK40.41174343
83CSNK1G20.40506896
84PRKCI0.39396750
85IGF1R0.38049848
86NME20.37191775
87ERBB30.37117303
88EPHA30.36718753
89CCNB10.35727735
90MAP3K50.35444600
91MAP2K30.35272902
92MAP3K110.35125374
93CSNK2A10.34262895
94PRKCD0.33523328
95PRKCH0.33003186
96PLK40.30730743
97DYRK1B0.30517820
98DAPK10.28066599
99CSNK2A20.27056581
100TRPM70.26089871

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.69561325
2Asthma_Homo sapiens_hsa053103.43352023
3Graft-versus-host disease_Homo sapiens_hsa053323.13869029
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.12890201
5Allograft rejection_Homo sapiens_hsa053303.04852729
6Autoimmune thyroid disease_Homo sapiens_hsa053202.89970940
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68881605
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.62202253
9Proteasome_Homo sapiens_hsa030502.49335514
10Antigen processing and presentation_Homo sapiens_hsa046122.48945285
11Type I diabetes mellitus_Homo sapiens_hsa049402.18345318
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.00075379
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99488262
14Hematopoietic cell lineage_Homo sapiens_hsa046401.94385899
15Mismatch repair_Homo sapiens_hsa034301.91803188
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90368623
17Leishmaniasis_Homo sapiens_hsa051401.82937258
18Staphylococcus aureus infection_Homo sapiens_hsa051501.82917217
19Homologous recombination_Homo sapiens_hsa034401.80161126
20Oxidative phosphorylation_Homo sapiens_hsa001901.79702642
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64547321
22Protein export_Homo sapiens_hsa030601.63323693
23Fanconi anemia pathway_Homo sapiens_hsa034601.61426364
24Rheumatoid arthritis_Homo sapiens_hsa053231.57747810
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57654561
26Parkinsons disease_Homo sapiens_hsa050121.48860698
27DNA replication_Homo sapiens_hsa030301.48417970
28Base excision repair_Homo sapiens_hsa034101.41817360
29Ribosome_Homo sapiens_hsa030101.37411703
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33279179
31Legionellosis_Homo sapiens_hsa051341.27202954
32Measles_Homo sapiens_hsa051621.26144706
33T cell receptor signaling pathway_Homo sapiens_hsa046601.24366029
34RNA polymerase_Homo sapiens_hsa030201.24091488
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22314250
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17722698
37Malaria_Homo sapiens_hsa051441.14998614
38Herpes simplex infection_Homo sapiens_hsa051681.14378023
39Non-homologous end-joining_Homo sapiens_hsa034501.12387547
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09611005
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08684512
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.03435796
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01148701
44Phototransduction_Homo sapiens_hsa047441.00659904
45Nucleotide excision repair_Homo sapiens_hsa034201.00145706
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97122318
47Basal transcription factors_Homo sapiens_hsa030220.93508133
48Linoleic acid metabolism_Homo sapiens_hsa005910.93075126
49Tuberculosis_Homo sapiens_hsa051520.91090227
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88877316
51Osteoclast differentiation_Homo sapiens_hsa043800.87978910
52Viral myocarditis_Homo sapiens_hsa054160.87762699
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87559372
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80579592
55RNA degradation_Homo sapiens_hsa030180.78263431
56Systemic lupus erythematosus_Homo sapiens_hsa053220.77794402
57Regulation of autophagy_Homo sapiens_hsa041400.76880133
58Alzheimers disease_Homo sapiens_hsa050100.76095389
59Peroxisome_Homo sapiens_hsa041460.75510375
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73390140
61Pyrimidine metabolism_Homo sapiens_hsa002400.69736875
62B cell receptor signaling pathway_Homo sapiens_hsa046620.68403697
63Huntingtons disease_Homo sapiens_hsa050160.67924152
64Influenza A_Homo sapiens_hsa051640.65887362
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64620445
66Spliceosome_Homo sapiens_hsa030400.63934591
67Tryptophan metabolism_Homo sapiens_hsa003800.61779261
68Nitrogen metabolism_Homo sapiens_hsa009100.61636593
69Purine metabolism_Homo sapiens_hsa002300.60403129
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57858012
71Toxoplasmosis_Homo sapiens_hsa051450.55603034
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53625251
73Propanoate metabolism_Homo sapiens_hsa006400.51892287
74Epstein-Barr virus infection_Homo sapiens_hsa051690.51466053
75African trypanosomiasis_Homo sapiens_hsa051430.51024993
76Chemokine signaling pathway_Homo sapiens_hsa040620.49805589
77One carbon pool by folate_Homo sapiens_hsa006700.49687905
78Phagosome_Homo sapiens_hsa041450.48446695
79Lysosome_Homo sapiens_hsa041420.47473895
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45981317
81Fatty acid degradation_Homo sapiens_hsa000710.44113480
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43903469
83Caffeine metabolism_Homo sapiens_hsa002320.43186645
84TNF signaling pathway_Homo sapiens_hsa046680.42971039
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42138249
86Arachidonic acid metabolism_Homo sapiens_hsa005900.41017445
87Ether lipid metabolism_Homo sapiens_hsa005650.37795542
88HTLV-I infection_Homo sapiens_hsa051660.37117231
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35999398
90Pertussis_Homo sapiens_hsa051330.34976957
91p53 signaling pathway_Homo sapiens_hsa041150.33268719
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.30380994
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.27309070
94Chemical carcinogenesis_Homo sapiens_hsa052040.27060885
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26802296
96Renin-angiotensin system_Homo sapiens_hsa046140.25659006
97Collecting duct acid secretion_Homo sapiens_hsa049660.25569076
98Dorso-ventral axis formation_Homo sapiens_hsa043200.24777057
99Shigellosis_Homo sapiens_hsa051310.21804903
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21087107

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