ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.00395585
2	ATP synthesis coupled proton transport (GO:0015986)	4.84601524
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.84601524
4	DNA deamination (GO:0045006)	4.72547505
5	behavioral response to nicotine (GO:0035095)	4.68899322
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.65208950
7	protein-cofactor linkage (GO:0018065)	4.60593049
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.21831238
9	response to pheromone (GO:0019236)	4.18416620
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.95919260
11	cell proliferation in forebrain (GO:0021846)	3.73825368
12	respiratory electron transport chain (GO:0022904)	3.57348824
13	electron transport chain (GO:0022900)	3.56146239
14	protein complex biogenesis (GO:0070271)	3.55795609
15	regulation of penile erection (GO:0060405)	3.50954092
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49356181
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49356181
18	NADH dehydrogenase complex assembly (GO:0010257)	3.49356181
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39510924
20	cytidine deamination (GO:0009972)	3.31116113
21	cytidine metabolic process (GO:0046087)	3.31116113
22	cytidine catabolic process (GO:0006216)	3.31116113
23	sulfation (GO:0051923)	3.27722052
24	chaperone-mediated protein transport (GO:0072321)	3.22247180
25	one-carbon compound transport (GO:0019755)	3.18754615
26	parturition (GO:0007567)	3.15121334
27	platelet dense granule organization (GO:0060155)	3.13871871
28	axoneme assembly (GO:0035082)	3.13163863
29	negative regulation of mast cell activation (GO:0033004)	3.13136256
30	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.11327599
31	seminiferous tubule development (GO:0072520)	3.11231761
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.08214211
33	base-excision repair, AP site formation (GO:0006285)	2.91915934
34	interferon-gamma production (GO:0032609)	2.91648578
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.91561667
36	transmission of nerve impulse (GO:0019226)	2.90200481
37	somite development (GO:0061053)	2.89672959
38	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.88530043
39	glycine transport (GO:0015816)	2.83527643
40	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.79648914
41	cellular biogenic amine catabolic process (GO:0042402)	2.78728440
42	amine catabolic process (GO:0009310)	2.78728440
43	sequestering of actin monomers (GO:0042989)	2.78249199
44	neuronal action potential propagation (GO:0019227)	2.76071253
45	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.75405048
46	neuron fate determination (GO:0048664)	2.72241085
47	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.71734040
48	L-fucose catabolic process (GO:0042355)	2.71383433
49	fucose catabolic process (GO:0019317)	2.71383433
50	L-fucose metabolic process (GO:0042354)	2.71383433
51	piRNA metabolic process (GO:0034587)	2.69032503
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.68620065
53	negative regulation of T cell apoptotic process (GO:0070233)	2.67705450
54	hydrogen ion transmembrane transport (GO:1902600)	2.66159312
55	male meiosis I (GO:0007141)	2.64822916
56	ATP biosynthetic process (GO:0006754)	2.62274065
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62215471
58	gamma-aminobutyric acid transport (GO:0015812)	2.59946292
59	cytolysis (GO:0019835)	2.59671731
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59231178
61	regulation of neurotransmitter uptake (GO:0051580)	2.58940149
62	sex differentiation (GO:0007548)	2.56912261
63	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.56648529
64	pyrimidine nucleotide catabolic process (GO:0006244)	2.56340546
65	proton transport (GO:0015992)	2.56190920
66	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.56107220
67	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.56107220
68	deoxyribonucleotide catabolic process (GO:0009264)	2.56074687
69	respiratory chain complex IV assembly (GO:0008535)	2.55619421
70	indolalkylamine metabolic process (GO:0006586)	2.54943635
71	mannosylation (GO:0097502)	2.54558080
72	regulation of thymocyte apoptotic process (GO:0070243)	2.53303105
73	response to amphetamine (GO:0001975)	2.53023837
74	hydrogen transport (GO:0006818)	2.51370304
75	cytochrome complex assembly (GO:0017004)	2.51206255
76	behavioral response to ethanol (GO:0048149)	2.48340185
77	replication fork processing (GO:0031297)	2.47871597
78	estrogen biosynthetic process (GO:0006703)	2.46692918
79	negative regulation of cation channel activity (GO:2001258)	2.46222566
80	synaptic transmission, cholinergic (GO:0007271)	2.45927700
81	synaptic transmission, dopaminergic (GO:0001963)	2.44424823
82	aldehyde catabolic process (GO:0046185)	2.44239681
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43534889
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43534889
85	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.43161162
86	behavioral response to cocaine (GO:0048148)	2.43010494
87	left/right axis specification (GO:0070986)	2.41320544
88	negative regulation of lyase activity (GO:0051350)	2.41250147
89	negative regulation of thymocyte apoptotic process (GO:0070244)	2.41039478
90	negative regulation of adenylate cyclase activity (GO:0007194)	2.40214859
91	indolalkylamine catabolic process (GO:0046218)	2.39825862
92	tryptophan catabolic process (GO:0006569)	2.39825862
93	indole-containing compound catabolic process (GO:0042436)	2.39825862
94	prenylation (GO:0097354)	2.39801084
95	protein prenylation (GO:0018342)	2.39801084
96	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.39324453
97	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.38424266
98	anterograde synaptic vesicle transport (GO:0048490)	2.37768956
99	viral protein processing (GO:0019082)	2.37586995
100	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.36386704

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.98511112
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10218353
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94772126
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.86759700
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71198317
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50011018
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35148526
8	VDR_22108803_ChIP-Seq_LS180_Human	2.28364795
9	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.26382684
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08562093
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01995772
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.97334479
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.96601741
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.95274959
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.86938546
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82138432
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.80410828
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79619440
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.79064690
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.73015493
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.72174789
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.64946406
23	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.64889125
24	P300_19829295_ChIP-Seq_ESCs_Human	1.63399507
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62591480
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61226206
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56688060
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50730330
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.50147754
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49862726
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49172596
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46164832
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45554302
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45554302
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45253527
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44681620
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42452968
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.41932718
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41932718
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40822257
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.40482109
42	NCOR_22424771_ChIP-Seq_293T_Human	1.39210157
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37662052
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.37176979
45	GATA3_26560356_Chip-Seq_TH2_Human	1.36324158
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34201228
47	AR_20517297_ChIP-Seq_VCAP_Human	1.33743931
48	EWS_26573619_Chip-Seq_HEK293_Human	1.31855511
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31780099
50	FUS_26573619_Chip-Seq_HEK293_Human	1.29703864
51	TAF15_26573619_Chip-Seq_HEK293_Human	1.29390846
52	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.26473583
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26396420
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24757945
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23800085
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21249886
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20824273
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20364312
59	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19666816
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19612027
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17108138
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17108138
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15383680
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14758709
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.13911572
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13361996
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.11907444
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10699976
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09341981
70	ERA_21632823_ChIP-Seq_H3396_Human	1.09145433
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.08749119
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07575150
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05176008
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.03919063
75	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02891492
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02183801
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02073983
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01906846
79	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01185278
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01083322
81	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00874075
82	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00431434
83	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.99825905
84	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97775226
85	ER_23166858_ChIP-Seq_MCF-7_Human	0.97749551
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97228313
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.97207290
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97068405
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96356983
90	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96208967
91	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.96117257
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95026912
93	AR_25329375_ChIP-Seq_VCAP_Human	0.94982229
94	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94921822
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.94060890
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93700837
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93396071
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92834633
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92780220
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92199320

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.75071416
2	MP0008877_abnormal_DNA_methylation	3.43609171
3	MP0003787_abnormal_imprinting	3.29873991
4	MP0005671_abnormal_response_to	3.02330464
5	MP0000569_abnormal_digit_pigmentation	2.95574351
6	MP0005360_urolithiasis	2.79382654
7	MP0006292_abnormal_olfactory_placode	2.48849895
8	MP0009379_abnormal_foot_pigmentation	2.32418609
9	MP0002163_abnormal_gland_morphology	2.17721129
10	MP0002876_abnormal_thyroid_physiology	2.12930543
11	MP0005174_abnormal_tail_pigmentation	2.06811716
12	MP0005646_abnormal_pituitary_gland	2.06550079
13	MP0006072_abnormal_retinal_apoptosis	2.00479314
14	MP0004142_abnormal_muscle_tone	1.95185073
15	MP0003121_genomic_imprinting	1.90502304
16	MP0009046_muscle_twitch	1.87012736
17	MP0001986_abnormal_taste_sensitivity	1.86868058
18	MP0005551_abnormal_eye_electrophysiolog	1.82974431
19	MP0002837_dystrophic_cardiac_calcinosis	1.81137694
20	MP0005379_endocrine/exocrine_gland_phen	1.73893253
21	MP0003646_muscle_fatigue	1.70528132
22	MP0001968_abnormal_touch/_nociception	1.69486506
23	MP0002653_abnormal_ependyma_morphology	1.64645089
24	MP0002938_white_spotting	1.60331246
25	MP0002736_abnormal_nociception_after	1.59932402
26	MP0002272_abnormal_nervous_system	1.56965511
27	MP0008872_abnormal_physiological_respon	1.56095211
28	MP0000372_irregular_coat_pigmentation	1.54064544
29	MP0009745_abnormal_behavioral_response	1.53774874
30	MP0002095_abnormal_skin_pigmentation	1.53664236
31	MP0006276_abnormal_autonomic_nervous	1.52290793
32	MP0001529_abnormal_vocalization	1.50914443
33	MP0003878_abnormal_ear_physiology	1.49418867
34	MP0005377_hearing/vestibular/ear_phenot	1.49418867
35	MP0001905_abnormal_dopamine_level	1.47512841
36	MP0004742_abnormal_vestibular_system	1.46531580
37	MP0004885_abnormal_endolymph	1.41163016
38	MP0002928_abnormal_bile_duct	1.31611077
39	MP0001835_abnormal_antigen_presentation	1.30734018
40	MP0001485_abnormal_pinna_reflex	1.28102795
41	MP0003122_maternal_imprinting	1.26123621
42	MP0005084_abnormal_gallbladder_morpholo	1.24223680
43	MP0004145_abnormal_muscle_electrophysio	1.23261633
44	MP0008875_abnormal_xenobiotic_pharmacok	1.23050733
45	MP0001756_abnormal_urination	1.22890564
46	MP0003880_abnormal_central_pattern	1.22396572
47	MP0000778_abnormal_nervous_system	1.13556299
48	MP0002557_abnormal_social/conspecific_i	1.13077789
49	MP0005410_abnormal_fertilization	1.13026608
50	MP0001501_abnormal_sleep_pattern	1.12228530
51	MP0001970_abnormal_pain_threshold	1.11942795
52	MP0002102_abnormal_ear_morphology	1.11672190
53	MP0002572_abnormal_emotion/affect_behav	1.11340931
54	MP0003123_paternal_imprinting	1.10193569
55	MP0009384_cardiac_valve_regurgitation	1.07106369
56	MP0005389_reproductive_system_phenotype	1.05710425
57	MP0000427_abnormal_hair_cycle	1.05338828
58	MP0004147_increased_porphyrin_level	1.01751038
59	MP0005332_abnormal_amino_acid	1.00539330
60	MP0004133_heterotaxia	1.00538143
61	MP0005253_abnormal_eye_physiology	1.00325308
62	MP0002733_abnormal_thermal_nociception	1.00308084
63	MP0003806_abnormal_nucleotide_metabolis	1.00236400
64	MP0001440_abnormal_grooming_behavior	0.99925518
65	MP0002132_abnormal_respiratory_system	0.99723032
66	MP0009785_altered_susceptibility_to	0.98951222
67	MP0000685_abnormal_immune_system	0.98442912
68	MP0002067_abnormal_sensory_capabilities	0.97862870
69	MP0000230_abnormal_systemic_arterial	0.96816445
70	MP0000026_abnormal_inner_ear	0.96115203
71	MP0001486_abnormal_startle_reflex	0.95783277
72	MP0002909_abnormal_adrenal_gland	0.95509374
73	MP0005645_abnormal_hypothalamus_physiol	0.95235908
74	MP0005075_abnormal_melanosome_morpholog	0.95182089
75	MP0002160_abnormal_reproductive_system	0.92823386
76	MP0003635_abnormal_synaptic_transmissio	0.91513065
77	MP0000631_abnormal_neuroendocrine_gland	0.91365268
78	MP0009333_abnormal_splenocyte_physiolog	0.88840636
79	MP0001919_abnormal_reproductive_system	0.88570735
80	MP0002064_seizures	0.87882052
81	MP0002734_abnormal_mechanical_nocicepti	0.86889519
82	MP0008775_abnormal_heart_ventricle	0.86031505
83	MP0008789_abnormal_olfactory_epithelium	0.82394958
84	MP0002752_abnormal_somatic_nervous	0.81846126
85	MP0003011_delayed_dark_adaptation	0.81819875
86	MP0004134_abnormal_chest_morphology	0.79936116
87	MP0001984_abnormal_olfaction	0.79342630
88	MP0005195_abnormal_posterior_eye	0.79326512
89	MP0001963_abnormal_hearing_physiology	0.79170922
90	MP0003252_abnormal_bile_duct	0.79108585
91	MP0001293_anophthalmia	0.78530110
92	MP0002735_abnormal_chemical_nociception	0.78120327
93	MP0005636_abnormal_mineral_homeostasis	0.76915215
94	MP0004043_abnormal_pH_regulation	0.76477722
95	MP0002229_neurodegeneration	0.76432351
96	MP0004924_abnormal_behavior	0.75947488
97	MP0005386_behavior/neurological_phenoty	0.75947488
98	MP0010329_abnormal_lipoprotein_level	0.73082697
99	MP0009764_decreased_sensitivity_to	0.72602340
100	MP0001800_abnormal_humoral_immune	0.72210109

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoproteinemia (HP:0003075)	3.85217091
2	Molar tooth sign on MRI (HP:0002419)	3.77452517
3	Abnormality of midbrain morphology (HP:0002418)	3.77452517
4	Severe combined immunodeficiency (HP:0004430)	3.77034901
5	Panhypogammaglobulinemia (HP:0003139)	3.58848311
6	IgG deficiency (HP:0004315)	3.46616316
7	True hermaphroditism (HP:0010459)	3.32339285
8	Pancreatic fibrosis (HP:0100732)	3.24672994
9	Thyroiditis (HP:0100646)	3.20680118
10	Mitochondrial inheritance (HP:0001427)	3.19912633
11	Pancreatic cysts (HP:0001737)	3.06842002
12	Renal cortical cysts (HP:0000803)	3.00618430
13	Hypoplasia of the thymus (HP:0000778)	2.98373662
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.93306146
15	Combined immunodeficiency (HP:0005387)	2.90099889
16	Type II lissencephaly (HP:0007260)	2.89371198
17	Acute necrotizing encephalopathy (HP:0006965)	2.89046347
18	Abnormality of the renal cortex (HP:0011035)	2.81567140
19	Hepatocellular necrosis (HP:0001404)	2.78304094
20	Increased CSF lactate (HP:0002490)	2.77848494
21	Retinal dysplasia (HP:0007973)	2.74613383
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.74578142
23	Thyroid-stimulating hormone excess (HP:0002925)	2.74097122
24	Nephronophthisis (HP:0000090)	2.72439457
25	Hepatic necrosis (HP:0002605)	2.69326086
26	Acute encephalopathy (HP:0006846)	2.68803242
27	Abnormality of B cell number (HP:0010975)	2.64914376
28	T lymphocytopenia (HP:0005403)	2.63766671
29	Reticulocytopenia (HP:0001896)	2.56180755
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.48969831
31	Abnormality of T cells (HP:0002843)	2.48629901
32	Congenital stationary night blindness (HP:0007642)	2.48186560
33	Abnormality of the pons (HP:0007361)	2.47925256
34	B lymphocytopenia (HP:0010976)	2.46753554
35	Medial flaring of the eyebrow (HP:0010747)	2.46554147
36	Abnormality of T cell number (HP:0011839)	2.45256152
37	Sclerocornea (HP:0000647)	2.44897538
38	Cerebellar dysplasia (HP:0007033)	2.38895105
39	Progressive macrocephaly (HP:0004481)	2.37519802
40	Septo-optic dysplasia (HP:0100842)	2.36332949
41	Hypoplasia of the pons (HP:0012110)	2.30792739
42	Lissencephaly (HP:0001339)	2.30703471
43	Abnormality of the renal medulla (HP:0100957)	2.30347386
44	Aplastic anemia (HP:0001915)	2.25717071
45	3-Methylglutaconic aciduria (HP:0003535)	2.25646601
46	Increased hepatocellular lipid droplets (HP:0006565)	2.21232542
47	Renal Fanconi syndrome (HP:0001994)	2.17611865
48	Abolished electroretinogram (ERG) (HP:0000550)	2.17204731
49	Stomatitis (HP:0010280)	2.11676161
50	Pachygyria (HP:0001302)	2.11307808
51	Lipid accumulation in hepatocytes (HP:0006561)	2.09188399
52	Focal motor seizures (HP:0011153)	2.07646866
53	Tubular atrophy (HP:0000092)	2.05648726
54	Lactic acidosis (HP:0003128)	2.05585248
55	Pendular nystagmus (HP:0012043)	2.05509290
56	Myokymia (HP:0002411)	2.02098480
57	Increased serum lactate (HP:0002151)	2.01420580
58	Hypomagnesemia (HP:0002917)	1.98852338
59	Abnormal albumin level (HP:0012116)	1.98848876
60	Hypoalbuminemia (HP:0003073)	1.98848876
61	Gait imbalance (HP:0002141)	1.97458705
62	Flat capital femoral epiphysis (HP:0003370)	1.95068528
63	Colon cancer (HP:0003003)	1.95047853
64	Hemiplegia (HP:0002301)	1.93489782
65	Optic disc pallor (HP:0000543)	1.91956682
66	Anencephaly (HP:0002323)	1.91352790
67	Absent septum pellucidum (HP:0001331)	1.90913847
68	Polydipsia (HP:0001959)	1.89990855
69	Abnormal drinking behavior (HP:0030082)	1.89990855
70	Type 2 muscle fiber atrophy (HP:0003554)	1.89432685
71	Hemiparesis (HP:0001269)	1.88649843
72	Absent thumb (HP:0009777)	1.87252689
73	Increased corneal curvature (HP:0100692)	1.87162952
74	Keratoconus (HP:0000563)	1.87162952
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87009929
76	Abnormality of T cell physiology (HP:0011840)	1.86217429
77	Abnormality of eosinophils (HP:0001879)	1.86047074
78	Abnormality of magnesium homeostasis (HP:0004921)	1.85667137
79	Cystic liver disease (HP:0006706)	1.85511643
80	Postaxial foot polydactyly (HP:0001830)	1.84994935
81	Hyperglycinuria (HP:0003108)	1.84755343
82	Decreased central vision (HP:0007663)	1.84298523
83	Occipital encephalocele (HP:0002085)	1.83794244
84	Increased IgM level (HP:0003496)	1.82540186
85	Limb dystonia (HP:0002451)	1.80516827
86	Congenital primary aphakia (HP:0007707)	1.80149467
87	Leukodystrophy (HP:0002415)	1.78817233
88	Cerebral edema (HP:0002181)	1.77526587
89	Nephrogenic diabetes insipidus (HP:0009806)	1.77499245
90	Polyuria (HP:0000103)	1.77115094
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77114044
92	Optic nerve hypoplasia (HP:0000609)	1.75347919
93	Erythroderma (HP:0001019)	1.74089446
94	Chronic hepatic failure (HP:0100626)	1.73918792
95	Abnormality of the nasal septum (HP:0000419)	1.73071611
96	Abnormality of renal resorption (HP:0011038)	1.72309672
97	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.71805647
98	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.71805647
99	Severe muscular hypotonia (HP:0006829)	1.70997624
100	Abnormality of cells of the erythroid lineage (HP:0012130)	1.69220214

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.46370220
2	TAOK3	3.71253146
3	BCKDK	3.36273887
4	BMPR1B	2.84893492
5	KDR	2.36960741
6	PNCK	2.35840709
7	ADRBK2	2.33488601
8	STK16	2.28165453
9	NUAK1	2.25145376
10	MAP3K12	2.24388750
11	WNK3	2.22271115
12	FRK	1.97115618
13	TESK2	1.96465510
14	VRK1	1.94419689
15	MAP4K2	1.94008925
16	ZAK	1.91736229
17	LIMK1	1.82260601
18	MUSK	1.78230625
19	VRK2	1.74788727
20	GRK1	1.71641316
21	WNK4	1.69898400
22	CDK19	1.63634607
23	MAPK13	1.55220316
24	CDK8	1.52488492
25	TSSK6	1.49785042
26	PLK4	1.46734614
27	MAPK15	1.44323036
28	EPHA3	1.27014561
29	DYRK2	1.22808134
30	PIK3CG	1.18232131
31	MAP3K11	1.17657267
32	ITK	1.15101752
33	NTRK2	1.14000423
34	TNK2	1.13278781
35	ERBB3	1.09612603
36	CAMKK2	1.05009925
37	TLK1	1.03442579
38	MINK1	1.01037846
39	OXSR1	0.98170130
40	MAP4K1	0.97660785
41	MAPKAPK3	0.89507835
42	PLK3	0.89487779
43	TIE1	0.86197203
44	NME1	0.85573983
45	KIT	0.85161627
46	MARK1	0.81401996
47	PINK1	0.80309400
48	PRKCG	0.79404034
49	GRK7	0.78863403
50	TNIK	0.78785136
51	MAPKAPK5	0.78740906
52	RPS6KA5	0.72634517
53	STK39	0.69651852
54	EPHB2	0.68276948
55	PLK2	0.67041552
56	CSNK1G2	0.65694227
57	TEC	0.65195391
58	FLT3	0.65181880
59	NEK1	0.62225199
60	MARK3	0.62201233
61	PHKG2	0.61572118
62	PHKG1	0.61572118
63	EPHA4	0.61175964
64	INSRR	0.61132505
65	PAK3	0.60885885
66	TGFBR1	0.60042562
67	MYLK	0.59815645
68	WEE1	0.59768760
69	CSNK1G3	0.59471062
70	CASK	0.59293833
71	FES	0.57541219
72	TESK1	0.57454968
73	IRAK1	0.57258864
74	MAP2K7	0.56505834
75	CAMK1	0.56225438
76	IKBKE	0.56153633
77	PRKCQ	0.55899268
78	CDK3	0.55221491
79	PRKACA	0.51935548
80	CSF1R	0.49717191
81	MAP2K2	0.49652149
82	LYN	0.48572538
83	SYK	0.48512534
84	PRKCE	0.46596660
85	OBSCN	0.42852165
86	PRKCZ	0.40628482
87	CAMKK1	0.40199049
88	CSNK1A1	0.38455230
89	MST4	0.38106989
90	CSNK1G1	0.37315084
91	MKNK2	0.35572543
92	LCK	0.35009177
93	IKBKB	0.34661056
94	CHEK2	0.34653852
95	STK11	0.34347898
96	ACVR1B	0.33733911
97	CAMK2A	0.33584969
98	CSNK2A2	0.33517523
99	IGF1R	0.33330761
100	ATR	0.32171286

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.92148332
2	Parkinsons disease_Homo sapiens_hsa05012	3.32871035
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.14828125
4	Proteasome_Homo sapiens_hsa03050	2.64170210
5	Homologous recombination_Homo sapiens_hsa03440	2.57212631
6	Ribosome_Homo sapiens_hsa03010	2.50138170
7	Protein export_Homo sapiens_hsa03060	2.38166850
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34877639
9	Alzheimers disease_Homo sapiens_hsa05010	2.18095675
10	Huntingtons disease_Homo sapiens_hsa05016	2.16966456
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14329647
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.08703431
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05141917
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.02642699
15	Phototransduction_Homo sapiens_hsa04744	1.92556697
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88739540
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84373074
18	Butanoate metabolism_Homo sapiens_hsa00650	1.81039158
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73675865
20	Sulfur relay system_Homo sapiens_hsa04122	1.50792855
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.47663057
22	RNA polymerase_Homo sapiens_hsa03020	1.45684655
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42609306
24	Caffeine metabolism_Homo sapiens_hsa00232	1.42145457
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41256255
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.39762160
27	Peroxisome_Homo sapiens_hsa04146	1.38666585
28	Basal transcription factors_Homo sapiens_hsa03022	1.33224635
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.31225866
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30622235
31	Allograft rejection_Homo sapiens_hsa05330	1.29979295
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.29175009
33	One carbon pool by folate_Homo sapiens_hsa00670	1.27960069
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.26988147
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21456363
36	RNA degradation_Homo sapiens_hsa03018	1.20226185
37	Nicotine addiction_Homo sapiens_hsa05033	1.17661402
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.09998823
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.07362698
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00350850
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98385368
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97822858
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.97618681
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97360173
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96537209
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95067578
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94548829
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93517072
49	Non-homologous end-joining_Homo sapiens_hsa03450	0.88587821
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88282812
51	Propanoate metabolism_Homo sapiens_hsa00640	0.83129015
52	Purine metabolism_Homo sapiens_hsa00230	0.82406055
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82292216
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.80568091
55	Asthma_Homo sapiens_hsa05310	0.79686810
56	Spliceosome_Homo sapiens_hsa03040	0.76954374
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75903949
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75149153
59	Base excision repair_Homo sapiens_hsa03410	0.74810060
60	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.74731365
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74648602
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73240607
63	Mismatch repair_Homo sapiens_hsa03430	0.73060896
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72829127
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71424219
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70138338
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69631654
68	Taste transduction_Homo sapiens_hsa04742	0.69185398
69	Olfactory transduction_Homo sapiens_hsa04740	0.67533136
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67029922
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.65850280
72	Metabolic pathways_Homo sapiens_hsa01100	0.65010017
73	Fatty acid degradation_Homo sapiens_hsa00071	0.64449657
74	Morphine addiction_Homo sapiens_hsa05032	0.63006522
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61419619
76	Fatty acid elongation_Homo sapiens_hsa00062	0.60963751
77	DNA replication_Homo sapiens_hsa03030	0.60934167
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59279652
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.56493346
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53480739
81	Retinol metabolism_Homo sapiens_hsa00830	0.52543359
82	GABAergic synapse_Homo sapiens_hsa04727	0.44259373
83	Salivary secretion_Homo sapiens_hsa04970	0.43722221
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43413517
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39566474
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39408858
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.39006602
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33527172
89	Sulfur metabolism_Homo sapiens_hsa00920	0.33346528
90	Regulation of autophagy_Homo sapiens_hsa04140	0.32977913
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.31835646
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31609111
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31580003
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.30814269
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29512471
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29234958
97	Circadian entrainment_Homo sapiens_hsa04713	0.29100521
98	RNA transport_Homo sapiens_hsa03013	0.28188958
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27547823
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27507719

HMGB1P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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