ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein heterotetramerization (GO:0051290)	5.58195688
2	positive regulation of respiratory burst (GO:0060267)	5.06070847
3	presynaptic membrane assembly (GO:0097105)	4.48241739
4	nonmotile primary cilium assembly (GO:0035058)	4.37448259
5	response to pheromone (GO:0019236)	4.21248425
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.19609383
7	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.17794450
8	retinal cone cell development (GO:0046549)	4.15917992
9	intraciliary transport (GO:0042073)	4.10450065
10	positive regulation of glycolytic process (GO:0045821)	3.81905283
11	presynaptic membrane organization (GO:0097090)	3.79260478
12	exocrine pancreas development (GO:0031017)	3.75351203
13	protein localization to cilium (GO:0061512)	3.74523646
14	coenzyme catabolic process (GO:0009109)	3.68878613
15	negative regulation of protein localization to cell surface (GO:2000009)	3.66878309
16	ubiquinone biosynthetic process (GO:0006744)	3.61444737
17	ubiquinone metabolic process (GO:0006743)	3.51136246
18	aspartate family amino acid catabolic process (GO:0009068)	3.44046210
19	DNA deamination (GO:0045006)	3.38621899
20	photoreceptor cell development (GO:0042461)	3.33964737
21	cilium morphogenesis (GO:0060271)	3.33222566
22	regulation of cilium movement (GO:0003352)	3.29735241
23	eye photoreceptor cell development (GO:0042462)	3.26650279
24	cornea development in camera-type eye (GO:0061303)	3.22830558
25	protein polyglutamylation (GO:0018095)	3.21894767
26	pyrimidine nucleobase catabolic process (GO:0006208)	3.16979198
27	quinone biosynthetic process (GO:1901663)	3.14772955
28	replication fork processing (GO:0031297)	3.12210575
29	aldehyde catabolic process (GO:0046185)	3.09938438
30	lysine metabolic process (GO:0006553)	3.04584755
31	lysine catabolic process (GO:0006554)	3.04584755
32	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.02978772
33	branched-chain amino acid catabolic process (GO:0009083)	3.01355952
34	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98246961
35	regulation of mitotic spindle checkpoint (GO:1903504)	2.98246961
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.97409829
37	C4-dicarboxylate transport (GO:0015740)	2.95950541
38	positive regulation of amino acid transport (GO:0051957)	2.95850300
39	protein complex biogenesis (GO:0070271)	2.94913288
40	behavioral response to nicotine (GO:0035095)	2.93467844
41	detection of light stimulus involved in sensory perception (GO:0050962)	2.91676994
42	detection of light stimulus involved in visual perception (GO:0050908)	2.91676994
43	cellular response to sterol (GO:0036315)	2.91498970
44	xenobiotic catabolic process (GO:0042178)	2.90078668
45	rRNA catabolic process (GO:0016075)	2.88208385
46	olfactory bulb development (GO:0021772)	2.87062841
47	retinal ganglion cell axon guidance (GO:0031290)	2.84179302
48	cellular response to cholesterol (GO:0071397)	2.81813921
49	chaperone-mediated protein transport (GO:0072321)	2.81237571
50	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.78961485
51	signal peptide processing (GO:0006465)	2.78237349
52	serine family amino acid catabolic process (GO:0009071)	2.77549148
53	cellular ketone body metabolic process (GO:0046950)	2.76908456
54	respiratory chain complex IV assembly (GO:0008535)	2.75639359
55	cilium organization (GO:0044782)	2.75163540
56	protein neddylation (GO:0045116)	2.74720274
57	negative regulation of systemic arterial blood pressure (GO:0003085)	2.74371143
58	cilium assembly (GO:0042384)	2.70184830
59	tongue development (GO:0043586)	2.69575968
60	epithelial cilium movement (GO:0003351)	2.67167417
61	lactate metabolic process (GO:0006089)	2.66948787
62	smoothened signaling pathway (GO:0007224)	2.65595629
63	negative regulation of membrane potential (GO:0045837)	2.65334211
64	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.65292273
65	photoreceptor cell maintenance (GO:0045494)	2.65079098
66	neuron cell-cell adhesion (GO:0007158)	2.64787914
67	amino-acid betaine metabolic process (GO:0006577)	2.64654302
68	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.63398722
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.63128968
70	NADH dehydrogenase complex assembly (GO:0010257)	2.63128968
71	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.63128968
72	response to nitrosative stress (GO:0051409)	2.62854462
73	fucose catabolic process (GO:0019317)	2.62690559
74	L-fucose metabolic process (GO:0042354)	2.62690559
75	L-fucose catabolic process (GO:0042355)	2.62690559
76	male sex determination (GO:0030238)	2.62559363
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.61766963
78	retinal rod cell development (GO:0046548)	2.61077262
79	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.60611562
80	DNA catabolic process, exonucleolytic (GO:0000738)	2.60370645
81	adenosine metabolic process (GO:0046085)	2.56886410
82	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56767959
83	negative regulation of neurological system process (GO:0031645)	2.55821738
84	DNA double-strand break processing (GO:0000729)	2.55344691
85	postsynaptic membrane organization (GO:0001941)	2.51061990
86	vitamin biosynthetic process (GO:0009110)	2.49949262
87	cytochrome complex assembly (GO:0017004)	2.49110808
88	positive regulation of organic acid transport (GO:0032892)	2.48750558
89	peptidyl-histidine modification (GO:0018202)	2.48736271
90	ketone body metabolic process (GO:1902224)	2.48682548
91	nucleobase catabolic process (GO:0046113)	2.48595140
92	mannosylation (GO:0097502)	2.48170163
93	platelet dense granule organization (GO:0060155)	2.47826607
94	DNA demethylation (GO:0080111)	2.44949626
95	axoneme assembly (GO:0035082)	2.44060343
96	positive regulation of amine transport (GO:0051954)	2.43494903
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42980919
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.42974747
99	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.42194206
100	tryptophan metabolic process (GO:0006568)	2.41934130

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.60728269
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.06345962
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.99708589
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.86354069
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85080877
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81378155
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.77691480
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65448775
9	VDR_22108803_ChIP-Seq_LS180_Human	2.61917286
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57542100
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53074812
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.40944905
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.40489222
14	EWS_26573619_Chip-Seq_HEK293_Human	2.39411842
15	P300_19829295_ChIP-Seq_ESCs_Human	2.37676393
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35121146
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31474338
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29486096
19	FUS_26573619_Chip-Seq_HEK293_Human	2.29382963
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.23211094
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15995229
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02278637
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98082664
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83271825
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74619598
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66577377
27	TCF4_22108803_ChIP-Seq_LS180_Human	1.63224518
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59392453
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.58504111
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54853703
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54782815
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52086377
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50765977
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50190666
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49218892
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48220603
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47316886
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46343581
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46308667
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45911032
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45372516
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.44922986
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.42610491
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40279395
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37733544
46	STAT3_23295773_ChIP-Seq_U87_Human	1.37645543
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.35226295
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34551177
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34297721
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33953814
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31957405
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31206312
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.31206312
54	AR_25329375_ChIP-Seq_VCAP_Human	1.30981389
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30928897
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30928897
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28885127
58	TCF4_23295773_ChIP-Seq_U87_Human	1.28075292
59	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.27795314
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.27464506
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24926341
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.24799020
63	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.23752689
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22397620
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21182522
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.21116067
67	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.20190958
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19790394
69	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.19687582
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19060709
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19060709
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17211554
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.16280096
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15629286
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14808404
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08090779
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06995573
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.06553474
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05566759
80	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03432532
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03028711
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01431354
83	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01268765
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00986679
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00982775
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00545871
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00545871
88	JUN_21703547_ChIP-Seq_K562_Human	1.00172959
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99967148
90	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.99948597
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99009948
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98053405
93	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98037646
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97695725
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97084511
96	AR_20517297_ChIP-Seq_VCAP_Human	0.95969580
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95557575
98	NCOR_22424771_ChIP-Seq_293T_Human	0.95387857
99	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.93280753
100	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.92816520

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.11448456
2	MP0002638_abnormal_pupillary_reflex	3.06127687
3	MP0003136_yellow_coat_color	2.98170440
4	MP0005253_abnormal_eye_physiology	2.85984362
5	MP0003880_abnormal_central_pattern	2.85770448
6	MP0002102_abnormal_ear_morphology	2.78215640
7	MP0001984_abnormal_olfaction	2.71192710
8	MP0005084_abnormal_gallbladder_morpholo	2.59403231
9	MP0003011_delayed_dark_adaptation	2.43985032
10	MP0003646_muscle_fatigue	2.37243425
11	MP0005551_abnormal_eye_electrophysiolog	2.31823205
12	MP0006054_spinal_hemorrhage	2.17392312
13	MP0002163_abnormal_gland_morphology	2.15935297
14	MP0008058_abnormal_DNA_repair	1.95913741
15	MP0005365_abnormal_bile_salt	1.95685216
16	MP0008789_abnormal_olfactory_epithelium	1.92971804
17	MP0008877_abnormal_DNA_methylation	1.86326227
18	MP0002736_abnormal_nociception_after	1.83973683
19	MP0000372_irregular_coat_pigmentation	1.83639167
20	MP0001529_abnormal_vocalization	1.80659177
21	MP0002938_white_spotting	1.77830503
22	MP0001501_abnormal_sleep_pattern	1.71962025
23	MP0001486_abnormal_startle_reflex	1.66473521
24	MP0002751_abnormal_autonomic_nervous	1.63245000
25	MP0003195_calcinosis	1.61443187
26	MP0000383_abnormal_hair_follicle	1.57279060
27	MP0005646_abnormal_pituitary_gland	1.55063177
28	MP0009764_decreased_sensitivity_to	1.52259840
29	MP0000427_abnormal_hair_cycle	1.50000042
30	MP0009046_muscle_twitch	1.49855980
31	MP0005394_taste/olfaction_phenotype	1.48981306
32	MP0005499_abnormal_olfactory_system	1.48981306
33	MP0006276_abnormal_autonomic_nervous	1.46077700
34	MP0008872_abnormal_physiological_respon	1.43890548
35	MP0000516_abnormal_urinary_system	1.43697394
36	MP0005367_renal/urinary_system_phenotyp	1.43697394
37	MP0001968_abnormal_touch/_nociception	1.42138001
38	MP0002138_abnormal_hepatobiliary_system	1.37742241
39	MP0000631_abnormal_neuroendocrine_gland	1.35087358
40	MP0009745_abnormal_behavioral_response	1.34885874
41	MP0006035_abnormal_mitochondrial_morpho	1.32674158
42	MP0008775_abnormal_heart_ventricle	1.32002492
43	MP0005171_absent_coat_pigmentation	1.29362328
44	MP0006292_abnormal_olfactory_placode	1.28888788
45	MP0002254_reproductive_system_inflammat	1.28489875
46	MP0001986_abnormal_taste_sensitivity	1.24842947
47	MP0001293_anophthalmia	1.24401419
48	MP0002095_abnormal_skin_pigmentation	1.24105677
49	MP0004147_increased_porphyrin_level	1.22638041
50	MP0005379_endocrine/exocrine_gland_phen	1.22215218
51	MP0009053_abnormal_anal_canal	1.21051239
52	MP0002233_abnormal_nose_morphology	1.19877391
53	MP0005391_vision/eye_phenotype	1.19670518
54	MP0002837_dystrophic_cardiac_calcinosis	1.18029501
55	MP0000647_abnormal_sebaceous_gland	1.15973726
56	MP0004142_abnormal_muscle_tone	1.15785923
57	MP0005248_abnormal_Harderian_gland	1.15178996
58	MP0002272_abnormal_nervous_system	1.10784398
59	MP0003937_abnormal_limbs/digits/tail_de	1.10130028
60	MP0005075_abnormal_melanosome_morpholog	1.09367102
61	MP0002572_abnormal_emotion/affect_behav	1.08840484
62	MP0004043_abnormal_pH_regulation	1.07950708
63	MP0005085_abnormal_gallbladder_physiolo	1.06516345
64	MP0010678_abnormal_skin_adnexa	1.05772769
65	MP0002090_abnormal_vision	1.02834478
66	MP0002876_abnormal_thyroid_physiology	1.01686782
67	MP0002752_abnormal_somatic_nervous	1.01012121
68	MP0005195_abnormal_posterior_eye	0.95843491
69	MP0008875_abnormal_xenobiotic_pharmacok	0.95675293
70	MP0004215_abnormal_myocardial_fiber	0.94216939
71	MP0001764_abnormal_homeostasis	0.91145903
72	MP0001485_abnormal_pinna_reflex	0.90159191
73	MP0001119_abnormal_female_reproductive	0.89501336
74	MP0005670_abnormal_white_adipose	0.87511996
75	MP0005187_abnormal_penis_morphology	0.87084050
76	MP0009765_abnormal_xenobiotic_induced	0.86428950
77	MP0004084_abnormal_cardiac_muscle	0.85501655
78	MP0002064_seizures	0.85287108
79	MP0003119_abnormal_digestive_system	0.85240320
80	MP0000613_abnormal_salivary_gland	0.85067729
81	MP0005410_abnormal_fertilization	0.84179103
82	MP0002557_abnormal_social/conspecific_i	0.83956011
83	MP0010368_abnormal_lymphatic_system	0.83885481
84	MP0009697_abnormal_copulation	0.82693736
85	MP0001929_abnormal_gametogenesis	0.82085932
86	MP0003698_abnormal_male_reproductive	0.81591700
87	MP0001756_abnormal_urination	0.81302571
88	MP0002184_abnormal_innervation	0.80392812
89	MP0004019_abnormal_vitamin_homeostasis	0.79276487
90	MP0002067_abnormal_sensory_capabilities	0.78356592
91	MP0005167_abnormal_blood-brain_barrier	0.77329502
92	MP0001963_abnormal_hearing_physiology	0.76974291
93	MP0001970_abnormal_pain_threshold	0.76576662
94	MP0001324_abnormal_eye_pigmentation	0.75401760
95	MP0005448_abnormal_energy_balance	0.73816471
96	MP0004085_abnormal_heartbeat	0.72133786
97	MP0000579_abnormal_nail_morphology	0.70935322
98	MP0002234_abnormal_pharynx_morphology	0.69906557
99	MP0010094_abnormal_chromosome_stability	0.69224309
100	MP0002098_abnormal_vibrissa_morphology	0.68909669

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.81138866
2	Pancreatic islet-cell hyperplasia (HP:0004510)	4.50776943
3	Enlarged penis (HP:0000040)	3.89712529
4	Medial flaring of the eyebrow (HP:0010747)	3.82262019
5	Hypoglycemic seizures (HP:0002173)	3.76267919
6	Abnormality of midbrain morphology (HP:0002418)	3.65475883
7	Molar tooth sign on MRI (HP:0002419)	3.65475883
8	Hyperglycinemia (HP:0002154)	3.58810954
9	Pancreatic fibrosis (HP:0100732)	3.57527554
10	Hyperinsulinemic hypoglycemia (HP:0000825)	3.52515924
11	Gait imbalance (HP:0002141)	3.34933549
12	Hypoglycemic coma (HP:0001325)	3.33850868
13	Congenital primary aphakia (HP:0007707)	3.33395030
14	Pancreatic cysts (HP:0001737)	3.29965095
15	True hermaphroditism (HP:0010459)	3.28656798
16	Nephrogenic diabetes insipidus (HP:0009806)	3.19215758
17	Tubulointerstitial nephritis (HP:0001970)	3.09056880
18	Long foot (HP:0001833)	3.03935333
19	Nephronophthisis (HP:0000090)	2.89372880
20	Genital tract atresia (HP:0001827)	2.84891939
21	Vaginal atresia (HP:0000148)	2.80075823
22	Abnormality of serine family amino acid metabolism (HP:0010894)	2.73807790
23	Abnormality of glycine metabolism (HP:0010895)	2.73807790
24	Hyperglycinuria (HP:0003108)	2.68551299
25	Acute necrotizing encephalopathy (HP:0006965)	2.65532089
26	Postaxial foot polydactyly (HP:0001830)	2.65025976
27	Ketoacidosis (HP:0001993)	2.64905490
28	Methylmalonic acidemia (HP:0002912)	2.64437233
29	Acute encephalopathy (HP:0006846)	2.59392371
30	Polyphagia (HP:0002591)	2.56168640
31	Thick nail (HP:0001805)	2.55506129
32	Abnormality of the renal medulla (HP:0100957)	2.54327944
33	Ketosis (HP:0001946)	2.54177586
34	Postaxial hand polydactyly (HP:0001162)	2.52116620
35	Chronic hepatic failure (HP:0100626)	2.51344345
36	Symptomatic seizures (HP:0011145)	2.47352933
37	Atonic seizures (HP:0010819)	2.45242165
38	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.43061520
39	Progressive macrocephaly (HP:0004481)	2.41816929
40	Pendular nystagmus (HP:0012043)	2.41517599
41	Abnormality of the pancreatic islet cells (HP:0006476)	2.39372241
42	Abnormality of endocrine pancreas physiology (HP:0012093)	2.39372241
43	Renal hypoplasia (HP:0000089)	2.36513718
44	Abnormal mitochondria in muscle tissue (HP:0008316)	2.35428279
45	Methylmalonic aciduria (HP:0012120)	2.30323904
46	Elfin facies (HP:0004428)	2.29563750
47	Type II lissencephaly (HP:0007260)	2.28773566
48	Mitochondrial inheritance (HP:0001427)	2.24116931
49	Stenosis of the external auditory canal (HP:0000402)	2.23697820
50	Increased CSF lactate (HP:0002490)	2.22585322
51	Sclerocornea (HP:0000647)	2.21899656
52	Abnormality of the renal cortex (HP:0011035)	2.17459610
53	Hepatocellular necrosis (HP:0001404)	2.11186779
54	Preaxial hand polydactyly (HP:0001177)	2.10364542
55	Poor coordination (HP:0002370)	2.09984115
56	Broad foot (HP:0001769)	2.09565249
57	Hyperventilation (HP:0002883)	2.09525054
58	Short tibia (HP:0005736)	2.07822550
59	Intestinal atresia (HP:0011100)	2.07483067
60	Occipital encephalocele (HP:0002085)	2.03211586
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03184455
62	Attenuation of retinal blood vessels (HP:0007843)	2.03115897
63	Abolished electroretinogram (ERG) (HP:0000550)	2.02660602
64	Abnormality of the labia minora (HP:0012880)	2.01509402
65	Optic nerve hypoplasia (HP:0000609)	2.00561796
66	Median cleft lip (HP:0000161)	2.00445662
67	Volvulus (HP:0002580)	1.96436646
68	3-Methylglutaconic aciduria (HP:0003535)	1.94933442
69	Cystic liver disease (HP:0006706)	1.94808058
70	Oligodactyly (hands) (HP:0001180)	1.94713101
71	Abnormal rod and cone electroretinograms (HP:0008323)	1.94241742
72	Anencephaly (HP:0002323)	1.91844598
73	Hepatic necrosis (HP:0002605)	1.91251511
74	Abnormality of serum amino acid levels (HP:0003112)	1.90278758
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.89248855
76	Febrile seizures (HP:0002373)	1.88954007
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88424820
78	Gaze-evoked nystagmus (HP:0000640)	1.83456939
79	Insulin-resistant diabetes mellitus (HP:0000831)	1.82967773
80	Decreased central vision (HP:0007663)	1.81831765
81	Focal seizures (HP:0007359)	1.80776942
82	Cerebral edema (HP:0002181)	1.80147310
83	Small hand (HP:0200055)	1.79171680
84	Astigmatism (HP:0000483)	1.79085955
85	Congenital stationary night blindness (HP:0007642)	1.74236514
86	Congenital hepatic fibrosis (HP:0002612)	1.73596411
87	Retinal dysplasia (HP:0007973)	1.73321992
88	Ectopic kidney (HP:0000086)	1.72949207
89	Cutaneous finger syndactyly (HP:0010554)	1.72741605
90	Optic disc pallor (HP:0000543)	1.70768939
91	Cerebellar dysplasia (HP:0007033)	1.70744443
92	Tubulointerstitial abnormality (HP:0001969)	1.70622320
93	Keratoconus (HP:0000563)	1.70621742
94	Increased corneal curvature (HP:0100692)	1.70621742
95	Retinitis pigmentosa (HP:0000510)	1.70275824
96	Hip dysplasia (HP:0001385)	1.68902928
97	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.67206845
98	Hypoplastic pelvis (HP:0008839)	1.66756655
99	Lethargy (HP:0001254)	1.66539684
100	Increased serum lactate (HP:0002151)	1.65607752

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	8.84479133
2	FRK	4.14407399
3	MAP4K2	3.35801668
4	BMPR1B	3.30870324
5	WNK3	2.01429796
6	GRK1	1.98491506
7	TRIM28	1.85670685
8	CAMKK2	1.78695083
9	MKNK2	1.70095635
10	ZAK	1.62440875
11	PLK2	1.57598872
12	TIE1	1.56694813
13	NUAK1	1.47518180
14	PDK2	1.46757323
15	CSNK1G1	1.43948492
16	TGFBR1	1.42746451
17	TNIK	1.38233947
18	STK39	1.31737376
19	CSNK1G3	1.31041812
20	ADRBK2	1.30353565
21	DYRK2	1.27833051
22	CSNK1A1L	1.23624393
23	PAK3	1.22706395
24	CSNK1G2	1.21959867
25	BUB1	1.18317033
26	PLK3	1.18015745
27	CDK8	1.12094537
28	MARK1	1.09531811
29	MUSK	1.08984802
30	ACVR1B	1.08479203
31	BCKDK	1.08327002
32	MKNK1	1.05117069
33	MAP2K7	1.04202882
34	ERBB4	1.02214091
35	PINK1	1.01576182
36	WNK4	1.01569585
37	SRPK1	1.00196615
38	TXK	0.93900040
39	FER	0.90695677
40	VRK2	0.89268350
41	CASK	0.85148867
42	PRKCG	0.82444349
43	MAPK13	0.80186204
44	PIK3CA	0.76190645
45	BRSK2	0.74639901
46	OXSR1	0.74515474
47	MAP3K4	0.73378853
48	VRK1	0.73250023
49	EIF2AK3	0.70192423
50	STK38L	0.68432125
51	NME1	0.67027619
52	OBSCN	0.65572190
53	EPHB2	0.64797871
54	PLK4	0.64685911
55	PLK1	0.62881348
56	KDR	0.59392708
57	MAPKAPK3	0.58178362
58	GRK5	0.55276306
59	PRKCE	0.54696319
60	EPHA3	0.54448127
61	NEK6	0.53198970
62	EPHA4	0.51653281
63	PAK6	0.49526790
64	AKT3	0.49335978
65	CSNK1A1	0.48876374
66	TLK1	0.47916674
67	ADRBK1	0.47281892
68	FGFR2	0.44820418
69	FLT3	0.44365940
70	NTRK2	0.43315835
71	FES	0.43027706
72	CAMK1	0.42748462
73	PRKCQ	0.42309885
74	TGFBR2	0.41055590
75	CAMK2A	0.40707816
76	MINK1	0.40498942
77	BRD4	0.40334524
78	IGF1R	0.39581364
79	ERBB2	0.39183101
80	PRKACA	0.38680024
81	PKN1	0.38248040
82	ATM	0.37846817
83	PTK2B	0.36524110
84	KIT	0.35434084
85	ROCK1	0.35237061
86	DAPK2	0.33600001
87	PRKCA	0.33443587
88	CDK3	0.33310460
89	CSNK1D	0.32563989
90	YES1	0.31591999
91	MAP3K12	0.30878471
92	TNK2	0.29445575
93	TTK	0.29094756
94	CSNK2A1	0.28826909
95	PBK	0.28711774
96	STK16	0.28551460
97	ERBB3	0.27563116
98	NLK	0.27552876
99	GRK7	0.27282324
100	INSR	0.26820940

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.67668111
2	Propanoate metabolism_Homo sapiens_hsa00640	2.84133378
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.80004563
4	Proteasome_Homo sapiens_hsa03050	2.65662905
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.58915059
6	Butanoate metabolism_Homo sapiens_hsa00650	2.54698111
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.49253508
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.36533396
9	Protein export_Homo sapiens_hsa03060	1.99967116
10	Oxidative phosphorylation_Homo sapiens_hsa00190	1.91863938
11	Fatty acid degradation_Homo sapiens_hsa00071	1.83911626
12	RNA polymerase_Homo sapiens_hsa03020	1.81976760
13	beta-Alanine metabolism_Homo sapiens_hsa00410	1.78811708
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.77905087
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.72767049
16	Homologous recombination_Homo sapiens_hsa03440	1.65375609
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64032438
18	Basal transcription factors_Homo sapiens_hsa03022	1.60952376
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.58975672
20	Parkinsons disease_Homo sapiens_hsa05012	1.58005376
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.57167552
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56182762
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55502706
24	Peroxisome_Homo sapiens_hsa04146	1.54210446
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.52929046
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51581063
27	RNA degradation_Homo sapiens_hsa03018	1.42824873
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42074592
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41201329
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33197771
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.32424245
32	Base excision repair_Homo sapiens_hsa03410	1.31354800
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.29224172
34	Phototransduction_Homo sapiens_hsa04744	1.28270604
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.21749585
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21662997
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20659625
38	Nicotine addiction_Homo sapiens_hsa05033	1.17714865
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.17082620
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14051119
41	One carbon pool by folate_Homo sapiens_hsa00670	1.14002547
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.13616785
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.13357250
44	Taste transduction_Homo sapiens_hsa04742	1.12565166
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11299271
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.07810956
47	Glycerolipid metabolism_Homo sapiens_hsa00561	1.06854114
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06369435
49	Steroid biosynthesis_Homo sapiens_hsa00100	1.03556334
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03466388
51	Huntingtons disease_Homo sapiens_hsa05016	1.03338543
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01722998
53	Alzheimers disease_Homo sapiens_hsa05010	1.01380392
54	Fatty acid elongation_Homo sapiens_hsa00062	1.00519462
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95509047
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91709641
57	Histidine metabolism_Homo sapiens_hsa00340	0.89640931
58	Ribosome_Homo sapiens_hsa03010	0.87594200
59	Retinol metabolism_Homo sapiens_hsa00830	0.85810334
60	Olfactory transduction_Homo sapiens_hsa04740	0.85288500
61	Asthma_Homo sapiens_hsa05310	0.81849905
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77443395
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76766267
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76557661
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76381079
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.75853949
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.74404731
68	Glutathione metabolism_Homo sapiens_hsa00480	0.74128597
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.74030482
70	Caffeine metabolism_Homo sapiens_hsa00232	0.73218167
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71604484
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.71228214
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.69569784
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69447945
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68385201
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.66295698
77	Metabolic pathways_Homo sapiens_hsa01100	0.63603849
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.61828702
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61799401
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.60011434
81	Lysine degradation_Homo sapiens_hsa00310	0.59017168
82	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58237161
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57970003
84	Mismatch repair_Homo sapiens_hsa03430	0.57482527
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56500612
86	Purine metabolism_Homo sapiens_hsa00230	0.55533718
87	ABC transporters_Homo sapiens_hsa02010	0.55371679
88	Circadian rhythm_Homo sapiens_hsa04710	0.54549630
89	Morphine addiction_Homo sapiens_hsa05032	0.54286352
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50619264
91	RNA transport_Homo sapiens_hsa03013	0.50435306
92	Serotonergic synapse_Homo sapiens_hsa04726	0.49440982
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43923783
94	GABAergic synapse_Homo sapiens_hsa04727	0.43792419
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42088550
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35764475
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34685365
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32591575
99	DNA replication_Homo sapiens_hsa03030	0.32387878
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.32290993

HMGB1P35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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