HMGB1P37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.84923962
2cytidine catabolic process (GO:0006216)7.84923962
3cytidine deamination (GO:0009972)7.84923962
4DNA deamination (GO:0045006)7.40677616
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.87893933
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.59198303
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.35236605
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.35236605
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.63019457
10ATP synthesis coupled proton transport (GO:0015986)4.62251805
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62251805
12chaperone-mediated protein transport (GO:0072321)4.31764966
13behavioral response to nicotine (GO:0035095)4.16617670
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16150361
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.14353448
16protein neddylation (GO:0045116)4.08523252
17respiratory electron transport chain (GO:0022904)3.98638957
18protein complex biogenesis (GO:0070271)3.96220582
19electron transport chain (GO:0022900)3.91721528
20proteasome assembly (GO:0043248)3.73693731
21adaptation of signaling pathway (GO:0023058)3.71775674
22protein-cofactor linkage (GO:0018065)3.69571679
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.68931563
24NADH dehydrogenase complex assembly (GO:0010257)3.68931563
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68931563
26folic acid-containing compound biosynthetic process (GO:0009396)3.61300405
27pyrimidine nucleoside catabolic process (GO:0046135)3.57825183
28mitochondrial respiratory chain complex assembly (GO:0033108)3.48795369
29inner mitochondrial membrane organization (GO:0007007)3.47215224
30regulation of cellular amino acid metabolic process (GO:0006521)3.42697814
31positive regulation of B cell differentiation (GO:0045579)3.40870658
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40576699
33positive regulation of interleukin-8 secretion (GO:2000484)3.39802511
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35410122
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31340070
36cytolysis (GO:0019835)3.30029867
37purine nucleotide salvage (GO:0032261)3.27217772
38water-soluble vitamin biosynthetic process (GO:0042364)3.25069452
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23065446
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23065446
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22417016
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22417016
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22417016
44adenosine metabolic process (GO:0046085)3.16363756
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12846518
46pyrimidine-containing compound catabolic process (GO:0072529)3.11595859
47hydrogen ion transmembrane transport (GO:1902600)3.08287158
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04857379
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.04857379
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04146492
51ribosomal small subunit assembly (GO:0000028)3.03359928
52proton transport (GO:0015992)3.01820979
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.01762418
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01635632
55chromatin remodeling at centromere (GO:0031055)2.98646998
56respiratory chain complex IV assembly (GO:0008535)2.96215561
57hydrogen transport (GO:0006818)2.95997369
58CENP-A containing nucleosome assembly (GO:0034080)2.95938068
59DNA demethylation (GO:0080111)2.94907344
60DNA double-strand break processing (GO:0000729)2.94170958
61positive regulation of T cell apoptotic process (GO:0070234)2.91241206
62cytochrome complex assembly (GO:0017004)2.91187345
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90214390
64negative regulation by host of viral transcription (GO:0043922)2.88253781
65negative regulation of ligase activity (GO:0051352)2.86702122
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86702122
67sequestering of actin monomers (GO:0042989)2.85454654
68pseudouridine synthesis (GO:0001522)2.85379423
69T cell migration (GO:0072678)2.83542630
70metallo-sulfur cluster assembly (GO:0031163)2.83023890
71iron-sulfur cluster assembly (GO:0016226)2.83023890
72tRNA processing (GO:0008033)2.82758665
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82039886
74pyrimidine ribonucleoside metabolic process (GO:0046131)2.81850452
75eosinophil chemotaxis (GO:0048245)2.80517428
76regulation of chronic inflammatory response (GO:0002676)2.80448225
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.78452363
78maturation of SSU-rRNA (GO:0030490)2.75762933
79rRNA modification (GO:0000154)2.70458349
80regulation of interleukin-8 secretion (GO:2000482)2.68759838
81DNA dealkylation (GO:0035510)2.66874392
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66550323
83regulation of cellular amine metabolic process (GO:0033238)2.64573027
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.64515591
85piRNA metabolic process (GO:0034587)2.63422676
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63102459
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63064559
88regulation of B cell receptor signaling pathway (GO:0050855)2.62293834
89GTP biosynthetic process (GO:0006183)2.60831571
90positive regulation of natural killer cell mediated immunity (GO:0002717)2.60335396
91platelet dense granule organization (GO:0060155)2.60293532
92positive regulation of cell cycle arrest (GO:0071158)2.60172423
93kynurenine metabolic process (GO:0070189)2.60110748
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58858987
95purine-containing compound salvage (GO:0043101)2.58495367
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58139419
97purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56413527
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.55091870
99eosinophil migration (GO:0072677)2.53131750
100sulfur amino acid catabolic process (GO:0000098)2.52132164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.98301890
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94545671
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82523459
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.47789684
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.21934495
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18265069
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.12232323
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02275679
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90564106
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77004673
11EZH2_22144423_ChIP-Seq_EOC_Human2.74960014
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70125600
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42326087
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.27100159
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25983524
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23072736
17VDR_23849224_ChIP-Seq_CD4+_Human2.22116967
18VDR_22108803_ChIP-Seq_LS180_Human2.17626611
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10923275
20ZNF274_21170338_ChIP-Seq_K562_Hela2.07987695
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00972698
22FOXP3_21729870_ChIP-Seq_TREG_Human1.99308085
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82251712
24ELK1_19687146_ChIP-ChIP_HELA_Human1.76115545
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.63976510
26TP53_22573176_ChIP-Seq_HFKS_Human1.60699403
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52506352
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48939787
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46958607
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46793262
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44759324
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.41694078
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.40588498
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.39060313
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38976831
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38202232
37PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.38157150
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36552051
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34968680
40NCOR_22424771_ChIP-Seq_293T_Human1.34485346
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34226708
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33222223
43GATA3_26560356_Chip-Seq_TH2_Human1.27812683
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26494818
45IGF1R_20145208_ChIP-Seq_DFB_Human1.26106368
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25067913
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24815523
48GABP_19822575_ChIP-Seq_HepG2_Human1.24582747
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24548070
50HTT_18923047_ChIP-ChIP_STHdh_Human1.24128687
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19914902
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.19150108
53TAF2_19829295_ChIP-Seq_ESCs_Human1.18147329
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15877764
55MYB_26560356_Chip-Seq_TH2_Human1.15306849
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15050541
57EWS_26573619_Chip-Seq_HEK293_Human1.12758020
58CIITA_25753668_ChIP-Seq_RAJI_Human1.12174536
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.11989497
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.11915422
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.10850933
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10850933
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09932894
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09369703
65ER_23166858_ChIP-Seq_MCF-7_Human1.09154509
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08787242
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08362947
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07557367
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06326036
70AR_20517297_ChIP-Seq_VCAP_Human1.04364888
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03788134
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03458843
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.02343101
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01617835
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00861900
76NANOG_20526341_ChIP-Seq_ESCs_Human1.00436274
77MYC_18940864_ChIP-ChIP_HL60_Human1.00407199
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00299893
79NANOG_19829295_ChIP-Seq_ESCs_Human0.99513523
80SOX2_19829295_ChIP-Seq_ESCs_Human0.99513523
81MYC_19829295_ChIP-Seq_ESCs_Human0.98974725
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96905057
83BCAT_22108803_ChIP-Seq_LS180_Human0.95387684
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94800482
85CBP_20019798_ChIP-Seq_JUKART_Human0.93646136
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93646136
87MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92794273
88ERG_20517297_ChIP-Seq_VCAP_Human0.92442369
89THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92250862
90PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90725048
91DCP1A_22483619_ChIP-Seq_HELA_Human0.90118756
92HOXB7_26014856_ChIP-Seq_BT474_Human0.89354533
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87926203
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87906489
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.87658570
96PHF8_20622853_ChIP-Seq_HELA_Human0.87319829
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.87121746
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86451632
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86445005
100OCT4_20526341_ChIP-Seq_ESCs_Human0.86065868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.12028707
2MP0005671_abnormal_response_to4.00567155
3MP0004147_increased_porphyrin_level3.69428640
4MP0008877_abnormal_DNA_methylation2.52416673
5MP0002736_abnormal_nociception_after2.26899711
6MP0003806_abnormal_nucleotide_metabolis2.21298769
7MP0008872_abnormal_physiological_respon2.12541048
8MP0003646_muscle_fatigue2.09737594
9MP0009785_altered_susceptibility_to2.08451746
10MP0006292_abnormal_olfactory_placode2.05898621
11MP0002095_abnormal_skin_pigmentation2.03838973
12MP0009333_abnormal_splenocyte_physiolog2.01797703
13MP0001968_abnormal_touch/_nociception1.92836747
14MP0001873_stomach_inflammation1.88202572
15MP0005075_abnormal_melanosome_morpholog1.85025392
16MP0005360_urolithiasis1.84393680
17MP0001835_abnormal_antigen_presentation1.84283435
18MP0002102_abnormal_ear_morphology1.84219996
19MP0005551_abnormal_eye_electrophysiolog1.83382367
20MP0003763_abnormal_thymus_physiology1.77299610
21MP0000372_irregular_coat_pigmentation1.77103286
22MP0008995_early_reproductive_senescence1.72565830
23MP0005646_abnormal_pituitary_gland1.69520292
24MP0002876_abnormal_thyroid_physiology1.67470256
25MP0004885_abnormal_endolymph1.67435298
26MP0003786_premature_aging1.64885640
27MP0004742_abnormal_vestibular_system1.63311458
28MP0005645_abnormal_hypothalamus_physiol1.57450535
29MP0001919_abnormal_reproductive_system1.55292717
30MP0005389_reproductive_system_phenotype1.54064929
31MP0008875_abnormal_xenobiotic_pharmacok1.46745102
32MP0004145_abnormal_muscle_electrophysio1.44730297
33MP0002653_abnormal_ependyma_morphology1.43872398
34MP0001485_abnormal_pinna_reflex1.41465807
35MP0001800_abnormal_humoral_immune1.41459193
36MP0001905_abnormal_dopamine_level1.38380735
37MP0005410_abnormal_fertilization1.38061436
38MP0001188_hyperpigmentation1.36210327
39MP0003878_abnormal_ear_physiology1.36029568
40MP0005377_hearing/vestibular/ear_phenot1.36029568
41MP0005174_abnormal_tail_pigmentation1.30395163
42MP0002938_white_spotting1.30366717
43MP0002160_abnormal_reproductive_system1.30183303
44MP0002138_abnormal_hepatobiliary_system1.29829300
45MP0005670_abnormal_white_adipose1.27325205
46MP0009745_abnormal_behavioral_response1.26951282
47MP0002638_abnormal_pupillary_reflex1.23906676
48MP0005000_abnormal_immune_tolerance1.21433480
49MP0003011_delayed_dark_adaptation1.18547107
50MP0006082_CNS_inflammation1.17109535
51MP0002277_abnormal_respiratory_mucosa1.15389371
52MP0005332_abnormal_amino_acid1.13574268
53MP0004142_abnormal_muscle_tone1.12209604
54MP0002148_abnormal_hypersensitivity_rea1.12022696
55MP0001486_abnormal_startle_reflex1.11764386
56MP0002006_tumorigenesis1.11111086
57MP0002166_altered_tumor_susceptibility1.11072687
58MP0002420_abnormal_adaptive_immunity1.09974039
59MP0001790_abnormal_immune_system1.09954333
60MP0005387_immune_system_phenotype1.09954333
61MP0002837_dystrophic_cardiac_calcinosis1.07091886
62MP0005025_abnormal_response_to1.05249233
63MP0003195_calcinosis1.05043014
64MP0002272_abnormal_nervous_system1.04584374
65MP0006036_abnormal_mitochondrial_physio1.03030602
66MP0003186_abnormal_redox_activity1.02870368
67MP0001819_abnormal_immune_cell1.02451437
68MP0001542_abnormal_bone_strength1.01873147
69MP0002723_abnormal_immune_serum1.01731155
70MP0005084_abnormal_gallbladder_morpholo1.00792904
71MP0003866_abnormal_defecation0.99884547
72MP0003183_abnormal_peptide_metabolism0.98081955
73MP0005636_abnormal_mineral_homeostasis0.95707230
74MP0003693_abnormal_embryo_hatching0.95087492
75MP0003787_abnormal_imprinting0.94932149
76MP0006072_abnormal_retinal_apoptosis0.92369121
77MP0000569_abnormal_digit_pigmentation0.88929166
78MP0003567_abnormal_fetal_cardiomyocyte0.87078528
79MP0001963_abnormal_hearing_physiology0.86822051
80MP0000703_abnormal_thymus_morphology0.86680500
81MP0000516_abnormal_urinary_system0.86492377
82MP0005367_renal/urinary_system_phenotyp0.86492377
83MP0005253_abnormal_eye_physiology0.85833877
84MP0002210_abnormal_sex_determination0.85329176
85MP0000015_abnormal_ear_pigmentation0.84428127
86MP0009765_abnormal_xenobiotic_induced0.83705733
87MP0000026_abnormal_inner_ear0.83267301
88MP0000716_abnormal_immune_system0.80908482
89MP0003880_abnormal_central_pattern0.80684215
90MP0009643_abnormal_urine_homeostasis0.80122906
91MP0001986_abnormal_taste_sensitivity0.79665991
92MP0002452_abnormal_antigen_presenting0.79610618
93MP0002733_abnormal_thermal_nociception0.79521021
94MP0001502_abnormal_circadian_rhythm0.78739449
95MP0006276_abnormal_autonomic_nervous0.78211024
96MP0001929_abnormal_gametogenesis0.77762536
97MP0000685_abnormal_immune_system0.76204626
98MP0008007_abnormal_cellular_replicative0.75503889
99MP0002398_abnormal_bone_marrow0.73814038
100MP0002234_abnormal_pharynx_morphology0.73668296

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.85479792
2Abnormality of alanine metabolism (HP:0010916)4.60035704
3Hyperalaninemia (HP:0003348)4.60035704
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.60035704
5Acute necrotizing encephalopathy (HP:0006965)4.48181491
6Mitochondrial inheritance (HP:0001427)4.16725575
7Abnormal mitochondria in muscle tissue (HP:0008316)3.98896188
8Acute encephalopathy (HP:0006846)3.71618069
9Increased CSF lactate (HP:0002490)3.68770214
10Progressive macrocephaly (HP:0004481)3.67941404
11Hepatocellular necrosis (HP:0001404)3.62715792
12Constricted visual fields (HP:0001133)3.40029777
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.30802574
14Hypoproteinemia (HP:0003075)3.25534834
15Hepatic necrosis (HP:0002605)3.04055753
16Cerebral edema (HP:0002181)3.00746472
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94018910
18Increased hepatocellular lipid droplets (HP:0006565)2.92491643
19Abnormality of midbrain morphology (HP:0002418)2.85041711
20Molar tooth sign on MRI (HP:0002419)2.85041711
21IgG deficiency (HP:0004315)2.79601312
22Renal Fanconi syndrome (HP:0001994)2.79114435
23Increased serum lactate (HP:0002151)2.74687820
24Pancytopenia (HP:0001876)2.68207454
25Autoimmune hemolytic anemia (HP:0001890)2.65944160
26Lactic acidosis (HP:0003128)2.62256113
27Lipid accumulation in hepatocytes (HP:0006561)2.61776571
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61771404
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61771404
30Lethargy (HP:0001254)2.55120799
31Abnormality of the prostate (HP:0008775)2.54050117
32Congenital stationary night blindness (HP:0007642)2.52231912
333-Methylglutaconic aciduria (HP:0003535)2.48044164
34Reticulocytopenia (HP:0001896)2.47769566
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47297454
36T lymphocytopenia (HP:0005403)2.47020608
37Abnormality of serum amino acid levels (HP:0003112)2.44288586
38Optic disc pallor (HP:0000543)2.40749138
39Pendular nystagmus (HP:0012043)2.38915354
40Congenital sensorineural hearing impairment (HP:0008527)2.36415527
41Abnormality of T cell number (HP:0011839)2.34077310
42Hyperglycinemia (HP:0002154)2.33985373
43Pancreatic fibrosis (HP:0100732)2.32568941
44Abolished electroretinogram (ERG) (HP:0000550)2.31930658
45Pancreatic cysts (HP:0001737)2.28741856
46Methylmalonic acidemia (HP:0002912)2.23375147
47Abnormality of B cell number (HP:0010975)2.23028261
48Increased intramyocellular lipid droplets (HP:0012240)2.22380000
49Absent thumb (HP:0009777)2.21093738
50Birth length less than 3rd percentile (HP:0003561)2.19940548
51Leukodystrophy (HP:0002415)2.18055611
52Chronic diarrhea (HP:0002028)2.16629503
53True hermaphroditism (HP:0010459)2.13256222
54Polydipsia (HP:0001959)2.10448217
55Abnormal drinking behavior (HP:0030082)2.10448217
56Abnormality of T cells (HP:0002843)2.07555178
57Attenuation of retinal blood vessels (HP:0007843)2.07433690
58Rib fusion (HP:0000902)2.03177060
59Methylmalonic aciduria (HP:0012120)2.03040130
60Medial flaring of the eyebrow (HP:0010747)2.02730574
61B lymphocytopenia (HP:0010976)2.02290403
62Stomatitis (HP:0010280)1.99984123
63Neutropenia (HP:0001875)1.99730545
64Supernumerary spleens (HP:0009799)1.99628260
65Severe combined immunodeficiency (HP:0004430)1.99502039
66Respiratory failure (HP:0002878)1.96883200
67Exercise intolerance (HP:0003546)1.96098739
68Elevated erythrocyte sedimentation rate (HP:0003565)1.93704608
69Abnormal albumin level (HP:0012116)1.90874877
70Hypoalbuminemia (HP:0003073)1.90874877
71Abnormality of cells of the erythroid lineage (HP:0012130)1.90453525
72Abnormality of the labia minora (HP:0012880)1.87813170
73Abnormal number of erythroid precursors (HP:0012131)1.86781696
74Generalized aminoaciduria (HP:0002909)1.86510332
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85603152
76Glycosuria (HP:0003076)1.83595315
77Abnormality of urine glucose concentration (HP:0011016)1.83595315
78Poor speech (HP:0002465)1.83524082
79Macrocytic anemia (HP:0001972)1.81806890
80Colon cancer (HP:0003003)1.79162654
81Abnormality of the renal collecting system (HP:0004742)1.77533123
82Anencephaly (HP:0002323)1.76319698
83Hyperphosphaturia (HP:0003109)1.75701402
84Abnormality of the renal cortex (HP:0011035)1.75373754
85Exertional dyspnea (HP:0002875)1.73920732
86Increased IgM level (HP:0003496)1.72765834
87Polyuria (HP:0000103)1.72340654
88Decreased central vision (HP:0007663)1.71292482
89Increased corneal curvature (HP:0100692)1.69978658
90Keratoconus (HP:0000563)1.69978658
91Renal cortical cysts (HP:0000803)1.68197215
92Increased muscle lipid content (HP:0009058)1.67713441
93Abnormality of eosinophils (HP:0001879)1.67118351
94Septo-optic dysplasia (HP:0100842)1.65847582
95Abnormality of renal resorption (HP:0011038)1.65532140
96Meckel diverticulum (HP:0002245)1.65083704
97Anorexia (HP:0002039)1.65002682
98Abnormal rod and cone electroretinograms (HP:0008323)1.64836672
99Tetany (HP:0001281)1.64365834
100Vomiting (HP:0002013)1.63798846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.93847883
2KDR3.57854238
3VRK23.22690630
4MAP4K23.16028784
5MAP4K12.55561173
6NUAK12.29706822
7TLK12.14695292
8BCKDK1.87363628
9BMPR1B1.81763434
10TAOK31.80625252
11WNK41.80289857
12MAP3K111.79575695
13CDC71.77533611
14GRK11.77223247
15STK161.76440522
16MST41.75188715
17MAP3K121.73122291
18ZAK1.69157284
19VRK11.64684956
20NTRK21.60207549
21ADRBK21.54353554
22DYRK21.53043305
23ITK1.50956453
24STK391.47553224
25MAPK131.33244045
26OXSR11.31362632
27TESK21.29686531
28PINK11.25993810
29TEC1.25402008
30SYK1.24953172
31WNK31.23266713
32NEK11.14865495
33MAP2K71.11589539
34FRK1.10605071
35BUB11.06265613
36LIMK11.03411453
37TAF10.98452707
38PRKCQ0.95011479
39IKBKB0.92329197
40AURKA0.89338640
41MUSK0.88932997
42INSRR0.88429881
43BTK0.80355526
44NME10.79696819
45PLK20.79248742
46PLK30.74322627
47FES0.73746144
48CDK90.73130478
49PLK10.69058835
50MARK10.68961308
51ATR0.67571510
52CSK0.66704400
53GRK50.66350297
54PRKCG0.65192924
55GRK70.64906529
56MYLK0.64068814
57PLK40.63802954
58CSNK1A10.62532806
59LYN0.61694737
60ADRBK10.61497699
61CHEK20.60226108
62LCK0.57717767
63MKNK20.57270172
64CAMK2D0.57136194
65PIK3CA0.56660007
66PDK20.55412646
67SRPK10.55024632
68CAMK2A0.54857096
69ABL20.54254567
70CSNK2A10.52737468
71PRKACA0.52015322
72TYRO30.51969726
73PIM20.51937175
74TIE10.49917357
75IGF1R0.49322787
76JAK30.47959084
77CSNK1G30.46536404
78PRKCA0.46054723
79OBSCN0.45522925
80CDK190.44386248
81EIF2AK30.44044799
82DAPK30.43358626
83GRK60.39814677
84PBK0.39133223
85CSNK2A20.39038521
86CAMK10.37836486
87PRKCD0.36572058
88RPS6KA50.36072396
89PRKCE0.35640892
90EIF2AK20.35037188
91TESK10.34968006
92CAMK2G0.34602595
93CSNK1G20.33955879
94ACVR1B0.33927402
95NTRK10.33577945
96CASK0.33441895
97NTRK30.32982512
98PHKG10.32860410
99PHKG20.32860410
100AURKB0.32167943

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65807275
2Oxidative phosphorylation_Homo sapiens_hsa001904.24885613
3Parkinsons disease_Homo sapiens_hsa050123.46643563
4Primary immunodeficiency_Homo sapiens_hsa053403.11134432
5Ribosome_Homo sapiens_hsa030102.72929669
6Protein export_Homo sapiens_hsa030602.64247931
7Huntingtons disease_Homo sapiens_hsa050162.41377283
8RNA polymerase_Homo sapiens_hsa030202.31431164
9Homologous recombination_Homo sapiens_hsa034402.29192359
10Alzheimers disease_Homo sapiens_hsa050102.24255344
11One carbon pool by folate_Homo sapiens_hsa006702.14152029
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11236931
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97517740
14Autoimmune thyroid disease_Homo sapiens_hsa053201.93125487
15Allograft rejection_Homo sapiens_hsa053301.72881511
16Cardiac muscle contraction_Homo sapiens_hsa042601.72150166
17Graft-versus-host disease_Homo sapiens_hsa053321.67280205
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64977940
19Collecting duct acid secretion_Homo sapiens_hsa049661.47187634
20Sulfur relay system_Homo sapiens_hsa041221.46729062
21RNA degradation_Homo sapiens_hsa030181.41178515
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40006175
23Fanconi anemia pathway_Homo sapiens_hsa034601.39399354
24Sulfur metabolism_Homo sapiens_hsa009201.39301298
25Phototransduction_Homo sapiens_hsa047441.31561257
26Nicotine addiction_Homo sapiens_hsa050331.31541423
27DNA replication_Homo sapiens_hsa030301.30665885
28Pyrimidine metabolism_Homo sapiens_hsa002401.28660723
29Mismatch repair_Homo sapiens_hsa034301.27832163
30Nitrogen metabolism_Homo sapiens_hsa009101.25821586
31Antigen processing and presentation_Homo sapiens_hsa046121.25503587
32Linoleic acid metabolism_Homo sapiens_hsa005911.25211995
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23100645
34Hematopoietic cell lineage_Homo sapiens_hsa046401.21374551
35Type I diabetes mellitus_Homo sapiens_hsa049401.20192213
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15583594
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14905552
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14441521
39Spliceosome_Homo sapiens_hsa030401.13134175
40Asthma_Homo sapiens_hsa053101.08033543
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.06178993
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03681895
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02890073
44Basal transcription factors_Homo sapiens_hsa030221.02660096
45Rheumatoid arthritis_Homo sapiens_hsa053231.00569138
46Ether lipid metabolism_Homo sapiens_hsa005650.97504150
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96035693
48Purine metabolism_Homo sapiens_hsa002300.95190286
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94924226
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94487489
51T cell receptor signaling pathway_Homo sapiens_hsa046600.93721265
52Butanoate metabolism_Homo sapiens_hsa006500.92134697
53Folate biosynthesis_Homo sapiens_hsa007900.86848389
54Peroxisome_Homo sapiens_hsa041460.81679635
55Morphine addiction_Homo sapiens_hsa050320.79766588
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78767219
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76897373
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.74204806
59Propanoate metabolism_Homo sapiens_hsa006400.73085626
60Metabolic pathways_Homo sapiens_hsa011000.71896295
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70150767
62Nucleotide excision repair_Homo sapiens_hsa034200.68871883
63Selenocompound metabolism_Homo sapiens_hsa004500.68618295
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.68185958
65Olfactory transduction_Homo sapiens_hsa047400.62595367
66Arginine biosynthesis_Homo sapiens_hsa002200.61642787
67Steroid biosynthesis_Homo sapiens_hsa001000.61234484
68GABAergic synapse_Homo sapiens_hsa047270.60490499
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60402162
70Retinol metabolism_Homo sapiens_hsa008300.59580843
71Caffeine metabolism_Homo sapiens_hsa002320.58642625
72Taste transduction_Homo sapiens_hsa047420.58189213
73Tryptophan metabolism_Homo sapiens_hsa003800.56471642
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54952200
75RNA transport_Homo sapiens_hsa030130.53443254
76Systemic lupus erythematosus_Homo sapiens_hsa053220.53150130
77Base excision repair_Homo sapiens_hsa034100.52030861
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48422987
79Vitamin digestion and absorption_Homo sapiens_hsa049770.47545616
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.43379440
81Fat digestion and absorption_Homo sapiens_hsa049750.40809081
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40313182
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40068265
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40038194
85Chemical carcinogenesis_Homo sapiens_hsa052040.39566651
86Arachidonic acid metabolism_Homo sapiens_hsa005900.37043516
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36162464
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35717190
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35062947
90Serotonergic synapse_Homo sapiens_hsa047260.33760842
91Fatty acid biosynthesis_Homo sapiens_hsa000610.32655300
92Synaptic vesicle cycle_Homo sapiens_hsa047210.31593722
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.28661329
94Glutamatergic synapse_Homo sapiens_hsa047240.28605593
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25974498
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.24367228
97beta-Alanine metabolism_Homo sapiens_hsa004100.24017435
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22508177
99Fatty acid degradation_Homo sapiens_hsa000710.21640557
100Mineral absorption_Homo sapiens_hsa049780.20746492

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