HMGB1P38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)9.76455369
2negative regulation of Ras GTPase activity (GO:0034261)6.64713154
3DNA synthesis involved in DNA repair (GO:0000731)6.59473468
4inositol phosphate dephosphorylation (GO:0046855)6.50229069
5phosphorylated carbohydrate dephosphorylation (GO:0046838)6.50229069
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.47156180
7protein import into peroxisome matrix (GO:0016558)6.45122969
8regulation of G0 to G1 transition (GO:0070316)6.12078314
9primary alcohol catabolic process (GO:0034310)5.95189661
10histone H4 deacetylation (GO:0070933)5.93311116
112-oxoglutarate metabolic process (GO:0006103)5.92661271
12inositol phosphate catabolic process (GO:0071545)5.89954971
13regulation of energy homeostasis (GO:2000505)5.86222464
14GMP metabolic process (GO:0046037)5.65324471
15regulation of interleukin-12 biosynthetic process (GO:0045075)5.63442846
16tricarboxylic acid metabolic process (GO:0072350)5.60066106
17positive regulation of RNA splicing (GO:0033120)5.54926377
18pyrimidine nucleoside salvage (GO:0043097)5.52808399
19pyrimidine-containing compound salvage (GO:0008655)5.52808399
20response to muscle activity (GO:0014850)4.99226076
21mitochondrion distribution (GO:0048311)4.93245161
22ribosomal small subunit assembly (GO:0000028)4.91906580
23histone H3 deacetylation (GO:0070932)4.84165760
24negative regulation of phagocytosis (GO:0050765)4.65962258
25positive regulation of Notch signaling pathway (GO:0045747)4.64724875
26phosphatidylcholine biosynthetic process (GO:0006656)4.58580145
27kidney morphogenesis (GO:0060993)4.54783703
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.52798316
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.51356873
30phosphatidylglycerol biosynthetic process (GO:0006655)4.48688474
31prostanoid biosynthetic process (GO:0046457)4.45795901
32prostaglandin biosynthetic process (GO:0001516)4.45795901
33positive regulation of chemokine secretion (GO:0090197)4.42339880
34response to vitamin D (GO:0033280)4.41612841
35viral transcription (GO:0019083)4.33463248
36regulation of cholesterol biosynthetic process (GO:0045540)4.29441658
37translational termination (GO:0006415)4.13847351
38response to histamine (GO:0034776)4.09067495
39detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.08676462
40detection of temperature stimulus involved in sensory perception (GO:0050961)4.08676462
41ribonucleoprotein complex biogenesis (GO:0022613)4.08047114
42cardiolipin metabolic process (GO:0032048)4.06926949
43production of molecular mediator involved in inflammatory response (GO:0002532)4.03884443
44sister chromatid cohesion (GO:0007062)4.01863485
45ribosomal large subunit biogenesis (GO:0042273)3.97182380
46protein localization to peroxisome (GO:0072662)3.93402213
47protein targeting to peroxisome (GO:0006625)3.93402213
48establishment of protein localization to peroxisome (GO:0072663)3.93402213
49regulation of gamma-delta T cell differentiation (GO:0045586)3.79832770
50polyol catabolic process (GO:0046174)3.77917208
51translational elongation (GO:0006414)3.77853708
52ethanol metabolic process (GO:0006067)3.75002408
53regulation of chemokine secretion (GO:0090196)3.73530361
54negative regulation of T-helper cell differentiation (GO:0045623)3.73159728
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.73159728
56nucleoside salvage (GO:0043174)3.71789887
57RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.69254128
58cellular response to virus (GO:0098586)3.63217304
59detection of mechanical stimulus (GO:0050982)3.57067150
60regulation of T-helper 1 cell differentiation (GO:0045625)3.56189405
61peroxisomal transport (GO:0043574)3.54103855
62activated T cell proliferation (GO:0050798)3.45497820
63positive regulation of macrophage activation (GO:0043032)3.39571320
64endothelial cell proliferation (GO:0001935)3.36326413
65viral life cycle (GO:0019058)3.33950351
66cellular protein complex disassembly (GO:0043624)3.28544372
67negative regulation of alpha-beta T cell differentiation (GO:0046639)3.28269791
68purine-containing compound salvage (GO:0043101)3.27252472
69negative regulation of GTPase activity (GO:0034260)3.27215110
70negative regulation of GTP catabolic process (GO:0033125)3.27215110
71developmental pigmentation (GO:0048066)3.21616042
72regulation of cytokine production involved in inflammatory response (GO:1900015)3.21582967
73bile acid biosynthetic process (GO:0006699)3.14445462
74detection of temperature stimulus (GO:0016048)3.12248772
75detection of mechanical stimulus involved in sensory perception (GO:0050974)3.09187275
76lymph node development (GO:0048535)3.07317834
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06419511
78cellular component biogenesis (GO:0044085)3.04638802
79regulation of gamma-delta T cell activation (GO:0046643)3.04367152
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02641264
81phenol-containing compound catabolic process (GO:0019336)3.01983420
82cotranslational protein targeting to membrane (GO:0006613)2.97481297
83cellular response to hepatocyte growth factor stimulus (GO:0035729)2.97047404
84response to hepatocyte growth factor (GO:0035728)2.97047404
85protein localization to microtubule (GO:0035372)2.95052718
86peptidyl-cysteine modification (GO:0018198)2.93696166
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93025999
88protein targeting to ER (GO:0045047)2.92636561
89negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.90825228
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89935392
91protein targeting to vacuole (GO:0006623)2.89107284
92protein targeting to lysosome (GO:0006622)2.89107284
93establishment of protein localization to vacuole (GO:0072666)2.89107284
94NAD metabolic process (GO:0019674)2.87360194
95regulation of T-helper 2 cell differentiation (GO:0045628)2.82593185
96protein localization to endoplasmic reticulum (GO:0070972)2.78265623
97cytoplasmic mRNA processing body assembly (GO:0033962)2.76453391
98ncRNA 3-end processing (GO:0043628)14.7337711
99ribosomal small subunit biogenesis (GO:0042274)13.3385480
100NADH metabolic process (GO:0006734)10.4649484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45138373
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.24309786
3EGR1_19032775_ChIP-ChIP_M12_Human2.96184245
4RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.92180743
5AR_21572438_ChIP-Seq_LNCaP_Human2.62056303
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36453149
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.22002748
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.17100064
9FUS_26573619_Chip-Seq_HEK293_Human2.01540880
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00307680
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat11.1049791
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98166800
13ERG_21242973_ChIP-ChIP_JURKAT_Human1.95175865
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91611456
15JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90102493
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86127278
17IRF1_19129219_ChIP-ChIP_H3396_Human1.85443620
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79045265
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77745915
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62231649
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.58258461
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57598419
23HTT_18923047_ChIP-ChIP_STHdh_Human1.56497290
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53149816
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52612786
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.51510193
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50233131
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50233131
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48897402
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48897402
31BCAT_22108803_ChIP-Seq_LS180_Human1.48238916
32RNF2_27304074_Chip-Seq_NSC_Mouse1.47549880
33P300_19829295_ChIP-Seq_ESCs_Human1.47411026
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45687201
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45127496
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44863006
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44761761
38NANOG_20526341_ChIP-Seq_ESCs_Human1.43884859
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42816277
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42349391
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42109286
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.40556202
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.36135065
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32091265
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.31998373
46EWS_26573619_Chip-Seq_HEK293_Human1.31445726
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27498119
48ERA_21632823_ChIP-Seq_H3396_Human1.26196088
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25796312
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20364857
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20020799
52BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16977301
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15980202
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15619436
55NCOR_22424771_ChIP-Seq_293T_Human1.15063366
56AR_25329375_ChIP-Seq_VCAP_Human1.14764980
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13675559
58SMRT_27268052_Chip-Seq_Bcells_Human1.13476479
59TAF15_26573619_Chip-Seq_HEK293_Human1.13446028
60JUN_21703547_ChIP-Seq_K562_Human1.12710653
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10447748
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10003206
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09548008
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08619599
65CTCF_27219007_Chip-Seq_Bcells_Human1.08389448
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07901962
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.06883417
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05054477
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.04786337
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04786337
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03411325
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99791515
73GBX2_23144817_ChIP-Seq_PC3_Human0.99332539
74TP53_22573176_ChIP-Seq_HFKS_Human0.98531664
75SOX2_19829295_ChIP-Seq_ESCs_Human0.98068614
76NANOG_19829295_ChIP-Seq_ESCs_Human0.98068614
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97212400
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96868828
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96637597
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96344041
81ZNF274_21170338_ChIP-Seq_K562_Hela0.96140305
82GABP_17652178_ChIP-ChIP_JURKAT_Human0.94727129
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93532820
84BCL6_27268052_Chip-Seq_Bcells_Human0.93303354
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93105465
86REST_21632747_ChIP-Seq_MESCs_Mouse0.89677251
87TRIM28_21343339_ChIP-Seq_HEK293_Human0.88762290
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.88432033
89RING1B_27294783_Chip-Seq_ESCs_Mouse0.88153871
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87814060
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86945525
92P300_27268052_Chip-Seq_Bcells_Human0.84326374
93OCT4_19829295_ChIP-Seq_ESCs_Human0.82770823
94TP53_16413492_ChIP-PET_HCT116_Human0.80095050
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.79891371
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79398614
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79269490
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79159632
99TAF2_19829295_ChIP-Seq_ESCs_Human0.78840173
100PHF8_20622854_ChIP-Seq_HELA_Human0.78816513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.95878339
2MP0001873_stomach_inflammation5.72872655
3MP0003879_abnormal_hair_cell5.45786999
4MP0003121_genomic_imprinting4.47830243
5MP0001727_abnormal_embryo_implantation4.17621094
6MP0009780_abnormal_chondrocyte_physiolo3.94622250
7MP0006292_abnormal_olfactory_placode2.78487374
8MP0002933_joint_inflammation2.71968923
9MP0004510_myositis10.5059843
10MP0001851_eye_inflammation1.85127804
11MP0003195_calcinosis1.81874963
12MP0001663_abnormal_digestive_system1.76214866
13MP0000566_synostosis1.69135945
14MP0005174_abnormal_tail_pigmentation1.68078070
15MP0002163_abnormal_gland_morphology1.67588176
16MP0005075_abnormal_melanosome_morpholog1.65713548
17MP0008875_abnormal_xenobiotic_pharmacok1.60718306
18MP0001915_intracranial_hemorrhage1.44645193
19MP0003938_abnormal_ear_development1.40220498
20MP0001905_abnormal_dopamine_level1.37095013
21MP0000015_abnormal_ear_pigmentation1.32514270
22MP0005551_abnormal_eye_electrophysiolog1.27743609
23MP0004742_abnormal_vestibular_system1.23538886
24MP0005381_digestive/alimentary_phenotyp1.22237411
25MP0009785_altered_susceptibility_to1.21003669
26MP0004947_skin_inflammation1.20888839
27MP0003787_abnormal_imprinting1.17552927
28MP0005646_abnormal_pituitary_gland1.13027083
29MP0009765_abnormal_xenobiotic_induced1.11251535
30MP0000026_abnormal_inner_ear1.08924164
31MP0002837_dystrophic_cardiac_calcinosis1.08575241
32MP0008877_abnormal_DNA_methylation1.05292673
33MP0009333_abnormal_splenocyte_physiolog1.03935186
34MP0002938_white_spotting0.95633121
35MP0002116_abnormal_craniofacial_bone0.94809922
36MP0006276_abnormal_autonomic_nervous0.93192837
37MP0004084_abnormal_cardiac_muscle0.91228489
38MP0001533_abnormal_skeleton_physiology0.89672919
39MP0002095_abnormal_skin_pigmentation0.88120374
40MP0001968_abnormal_touch/_nociception0.85680664
41MP0001800_abnormal_humoral_immune0.82824082
42MP0004133_heterotaxia0.82070424
43MP0005423_abnormal_somatic_nervous0.80238660
44MP0005379_endocrine/exocrine_gland_phen0.80136896
45MP0005195_abnormal_posterior_eye0.78515719
46MP0003693_abnormal_embryo_hatching0.77090424
47MP0002108_abnormal_muscle_morphology0.76621025
48MP0003880_abnormal_central_pattern0.74681817
49MP0002876_abnormal_thyroid_physiology0.74259132
50MP0002572_abnormal_emotion/affect_behav0.72472468
51MP0005084_abnormal_gallbladder_morpholo0.71941979
52MP0001970_abnormal_pain_threshold0.71228824
53MP0001963_abnormal_hearing_physiology0.71133083
54MP0002160_abnormal_reproductive_system0.67867304
55MP0009764_decreased_sensitivity_to0.65838818
56MP0002736_abnormal_nociception_after0.65004321
57MP0005197_abnormal_uvea_morphology0.64931553
58MP0002734_abnormal_mechanical_nocicepti0.64782785
59MP0002752_abnormal_somatic_nervous0.63992962
60MP0002405_respiratory_system_inflammati0.63987402
61MP0005671_abnormal_response_to0.63816081
62MP0002229_neurodegeneration0.60763999
63MP0002733_abnormal_thermal_nociception0.58248355
64MP0004145_abnormal_muscle_electrophysio0.57455186
65MP0002113_abnormal_skeleton_development0.57291103
66MP0002735_abnormal_chemical_nociception0.56191951
67MP0004215_abnormal_myocardial_fiber0.55923673
68MP0009745_abnormal_behavioral_response0.55836233
69MP0005377_hearing/vestibular/ear_phenot0.54919312
70MP0003878_abnormal_ear_physiology0.54919312
71MP0000703_abnormal_thymus_morphology0.54727511
72MP0002557_abnormal_social/conspecific_i0.54723469
73MP0003638_abnormal_response/metabolism_0.53307398
74MP0009250_abnormal_appendicular_skeleto0.53121086
75MP0002210_abnormal_sex_determination0.52479368
76MP0005645_abnormal_hypothalamus_physiol0.52386738
77MP0002272_abnormal_nervous_system0.51431446
78MP0004142_abnormal_muscle_tone0.51076887
79MP0005369_muscle_phenotype0.50731185
80MP0002998_abnormal_bone_remodeling0.50477555
81MP0009379_abnormal_foot_pigmentation0.49728524
82MP0003172_abnormal_lysosome_physiology0.49722545
83MP0003646_muscle_fatigue0.49242207
84MP0000689_abnormal_spleen_morphology0.49164144
85MP0002115_abnormal_skeleton_extremities0.45361765
86MP0000631_abnormal_neuroendocrine_gland0.44716482
87MP0000372_irregular_coat_pigmentation0.44576736
88MP0002063_abnormal_learning/memory/cond0.44313337
89MP0002067_abnormal_sensory_capabilities0.43217298
90MP0001340_abnormal_eyelid_morphology0.42636793
91MP0006072_abnormal_retinal_apoptosis0.42305930
92MP0003635_abnormal_synaptic_transmissio0.42047798
93MP0000778_abnormal_nervous_system0.41538295
94MP0003763_abnormal_thymus_physiology0.39782716
95MP0001485_abnormal_pinna_reflex0.39681834
96MP0003943_abnormal_hepatobiliary_system0.38638533
97MP0005389_reproductive_system_phenotype0.38299134
98MP0003755_abnormal_palate_morphology0.36567435
99MP0008995_early_reproductive_senescence0.36521492
100MP0001919_abnormal_reproductive_system0.36311424

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal cupping (HP:0003021)9.90536949
2Abnormality of macular pigmentation (HP:0008002)9.43689946
3Round ear (HP:0100830)9.38934198
4Striae distensae (HP:0001065)9.36516280
5Volvulus (HP:0002580)9.29392014
6Constricted visual fields (HP:0001133)8.47772217
7Cupped ribs (HP:0000887)8.01740323
8Cone-rod dystrophy (HP:0000548)7.38447118
9Toxemia of pregnancy (HP:0100603)6.68292205
10Large earlobe (HP:0009748)5.94018082
11Attenuation of retinal blood vessels (HP:0007843)5.93662622
12Decreased electroretinogram (ERG) amplitude (HP:0000654)5.76160934
13Broad nasal tip (HP:0000455)4.68914568
14Tibial bowing (HP:0002982)4.55790226
15Oligodontia (HP:0000677)4.54667820
16Ovoid vertebral bodies (HP:0003300)4.11382874
17Lack of skin elasticity (HP:0100679)4.09105965
18Decreased muscle mass (HP:0003199)4.02744696
19Small hand (HP:0200055)3.82267522
20Femoral bowing (HP:0002980)3.69596977
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.60068716
22Coxa vara (HP:0002812)3.59989165
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.54855693
24Hyperthyroidism (HP:0000836)3.41406702
25Severe visual impairment (HP:0001141)3.37217910
26Prominent supraorbital ridges (HP:0000336)3.33710789
27Limited elbow extension (HP:0001377)3.22719125
28Abnormality of the labia minora (HP:0012880)3.02485672
29Increased nuchal translucency (HP:0010880)2.94608141
30Proximal placement of thumb (HP:0009623)2.94422413
31Hypoplastic ilia (HP:0000946)2.90073926
32Brushfield spots (HP:0001088)2.88910693
33Blepharitis (HP:0000498)2.76752819
34Hematochezia (HP:0002573)2.70409134
35Optic disc pallor (HP:0000543)2.68814024
36Postnatal growth retardation (HP:0008897)2.65507190
37Rhizomelia (HP:0008905)2.63517006
38Recurrent otitis media (HP:0000403)2.57164878
39Deviation of the thumb (HP:0009603)2.55732249
40Progressive visual loss (HP:0000529)2.54816619
41Childhood onset (HP:0011463)2.47109048
42Aplasia/Hypoplasia of the nipples (HP:0006709)2.47091933
43Hypoplastic ischia (HP:0003175)2.46584318
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43489242
45Truncal obesity (HP:0001956)2.40400824
46Delayed puberty (HP:0000823)2.39995917
47Widely spaced teeth (HP:0000687)2.39132907
48Congenital, generalized hypertrichosis (HP:0004540)2.35302861
49Concave nail (HP:0001598)2.33532372
50Congenital sensorineural hearing impairment (HP:0008527)2.32443507
51Freckling (HP:0001480)2.31935044
52Prenatal maternal abnormality (HP:0002686)2.31245725
53Long eyelashes (HP:0000527)2.25086904
54Preauricular skin tag (HP:0000384)2.23621546
55Lymphedema (HP:0001004)2.21293927
56Abnormality of the ischium (HP:0003174)2.07925348
57Abnormality of lateral ventricle (HP:0030047)2.06929147
58Retinitis pigmentosa (HP:0000510)2.00606500
59Low posterior hairline (HP:0002162)1.89220360
60Atresia of the external auditory canal (HP:0000413)1.85126563
61Skin tags (HP:0010609)1.85115596
62Thyroid-stimulating hormone excess (HP:0002925)1.81881922
63Multicystic kidney dysplasia (HP:0000003)1.80239824
64Thickened nuchal skin fold (HP:0000474)1.78325258
65Albinism (HP:0001022)1.75977943
66Low anterior hairline (HP:0000294)1.72248103
67Neoplasm of the oral cavity (HP:0100649)1.72154752
68Abnormality of fatty-acid metabolism (HP:0004359)1.70050850
69Photophobia (HP:0000613)1.69020824
70IgM deficiency (HP:0002850)1.67268653
71Radioulnar synostosis (HP:0002974)1.66021134
72Epiphyseal stippling (HP:0010655)1.64866473
73Cutis marmorata (HP:0000965)1.64612162
74Short palm (HP:0004279)1.64336183
75Hip contracture (HP:0003273)1.62888554
76Astigmatism (HP:0000483)1.62189627
77Decreased testicular size (HP:0008734)1.62049234
78Hemiplegia (HP:0002301)1.55408240
79Akinesia (HP:0002304)1.54836240
80Agnosia (HP:0010524)1.52991102
81Tapered finger (HP:0001182)1.49743198
82Abnormality of the labia (HP:0000058)1.48737388
83Round face (HP:0000311)1.47569131
84Abnormality of the pubic bones (HP:0003172)1.45689908
85Melanoma (HP:0002861)1.44432747
86Hypoplastic labia majora (HP:0000059)1.42954898
87Muscle fiber splitting (HP:0003555)1.41817544
88Micropenis (HP:0000054)1.40741655
89Adrenal hypoplasia (HP:0000835)1.40533826
90Prominent nasal bridge (HP:0000426)1.38880615
91Abnormality of the antihelix (HP:0009738)1.38537145
92Pyloric stenosis (HP:0002021)1.38489251
93Pointed chin (HP:0000307)1.38460719
94Global brain atrophy (HP:0002283)1.37136926
95Inflammation of the large intestine (HP:0002037)1.34504319
96Primary amenorrhea (HP:0000786)1.33927068
97Asplenia (HP:0001746)1.33538305
98Abnormality of the labia majora (HP:0012881)1.33303050
99Split hand (HP:0001171)1.33214545
100Type II diabetes mellitus (HP:0005978)1.33203318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FES5.47509197
2TEC4.47418278
3SIK23.44329291
4TYRO33.24409543
5CDK192.51425980
6IKBKB2.28202992
7FRK2.02594753
8BCKDK2.01800168
9KIT10.1788203
10RET1.93756264
11SYK1.89184268
12TESK21.85969902
13CSK1.76428650
14NEK21.75294668
15INSRR1.54517949
16MAP4K11.51230725
17CDK31.45922094
18CSF1R1.30372268
19FGR1.29049559
20TIE11.19096081
21IKBKE1.07184095
22BMPR1B1.04299502
23ADRBK20.97871367
24RPS6KB20.93964020
25ADRBK10.93401070
26INSR0.90750976
27GRK10.89884025
28NTRK20.87072021
29PLK40.86193673
30EGFR0.75877351
31BTK0.73457278
32MAPK100.73314411
33LCK0.72468361
34WNK30.70414303
35SRC0.70324077
36MAP4K20.69264611
37CCNB10.69143667
38TESK10.68741007
39LIMK10.68613209
40TLK10.65896493
41PRKCG0.62640184
42KDR0.61470764
43JAK30.61014790
44GRK70.60843742
45PRKACA0.59483753
46DYRK20.58788327
47PRKCQ0.57807775
48LYN0.57162916
49OBSCN0.57124314
50CSNK1D0.56093177
51TBK10.55487082
52PKN10.54146481
53ABL20.53857575
54RPS6KA40.53605774
55FER0.47435667
56CDK80.47357095
57ABL10.46916977
58PRKACG0.45927519
59MAPK130.44112968
60OXSR10.41558310
61CDC70.40495393
62MINK10.40404814
63PRKCB0.40138272
64PRKCA0.39770820
65MAPK150.39441191
66MUSK0.39294659
67WNK40.39279139
68PAK30.39120239
69EPHB20.37123206
70CDK11A0.36592440
71CASK0.36229048
72CAMK2A0.36185418
73NUAK10.35905428
74ATM0.35096285
75CSNK1E0.31002549
76PRKACB0.30784504
77PIK3CG0.30656893
78CHEK20.30411551
79NTRK30.29055791
80TXK0.28485023
81PRKDC0.27854288
82CDK150.26593501
83PHKG20.26251673
84PHKG10.26251673
85FYN0.26077354
86TGFBR10.25024407
87PIK3CA0.23800904
88ZAK0.23608204
89PINK10.22186529
90CDK180.22026744
91WEE10.19336929
92CDK20.18710270
93PRKCE0.18450213
94MAP2K70.18336147
95EPHA40.18271981
96CSNK1A10.18149339
97CDK140.17715866
98FGFR20.17701739
99RPS6KA30.17600495
100ERBB20.17249886

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012105.83039318
2Phototransduction_Homo sapiens_hsa047444.24719909
3Ribosome_Homo sapiens_hsa030103.68713409
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34984579
5Histidine metabolism_Homo sapiens_hsa003403.03726102
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.01996159
7Oxidative phosphorylation_Homo sapiens_hsa001902.91308922
8Tryptophan metabolism_Homo sapiens_hsa003802.54981319
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22615743
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21301206
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20232853
12Olfactory transduction_Homo sapiens_hsa047402.02774112
13Mismatch repair_Homo sapiens_hsa034301.89404497
14beta-Alanine metabolism_Homo sapiens_hsa004101.87521420
15Nicotine addiction_Homo sapiens_hsa050331.84899655
16Parkinsons disease_Homo sapiens_hsa050121.82874925
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78832946
18Arachidonic acid metabolism_Homo sapiens_hsa005901.73312252
19Alzheimers disease_Homo sapiens_hsa050101.50820982
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48002400
21Alcoholism_Homo sapiens_hsa050341.46966844
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.46749266
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.30787083
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21329544
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16995488
26Glycerolipid metabolism_Homo sapiens_hsa005611.16335892
27Notch signaling pathway_Homo sapiens_hsa043301.14449556
28Long-term potentiation_Homo sapiens_hsa047201.06490464
29Huntingtons disease_Homo sapiens_hsa050161.04623819
30Fatty acid degradation_Homo sapiens_hsa000710.97885283
31Hematopoietic cell lineage_Homo sapiens_hsa046400.95303750
32Graft-versus-host disease_Homo sapiens_hsa053320.92998610
33Pyruvate metabolism_Homo sapiens_hsa006200.89257999
34Arginine and proline metabolism_Homo sapiens_hsa003300.87585098
35Butanoate metabolism_Homo sapiens_hsa006500.87053317
36Peroxisome_Homo sapiens_hsa041460.85838770
37Caffeine metabolism_Homo sapiens_hsa002320.84410308
38Bladder cancer_Homo sapiens_hsa052190.84047620
39Prion diseases_Homo sapiens_hsa050200.83753781
40Tyrosine metabolism_Homo sapiens_hsa003500.83752370
41Staphylococcus aureus infection_Homo sapiens_hsa051500.83705213
42Taste transduction_Homo sapiens_hsa047420.82228996
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82096857
44Linoleic acid metabolism_Homo sapiens_hsa005910.81332359
45FoxO signaling pathway_Homo sapiens_hsa040680.80235450
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79160035
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76665769
48Retinol metabolism_Homo sapiens_hsa008300.70684380
49Amphetamine addiction_Homo sapiens_hsa050310.70594246
50Fanconi anemia pathway_Homo sapiens_hsa034600.69582083
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69029729
52Biosynthesis of amino acids_Homo sapiens_hsa012300.68842921
53Choline metabolism in cancer_Homo sapiens_hsa052310.68454610
54Melanoma_Homo sapiens_hsa052180.66884678
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66776375
56Homologous recombination_Homo sapiens_hsa034400.63249924
57Calcium signaling pathway_Homo sapiens_hsa040200.61300689
58Serotonergic synapse_Homo sapiens_hsa047260.60420905
59Morphine addiction_Homo sapiens_hsa050320.60125775
60Cocaine addiction_Homo sapiens_hsa050300.59908697
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58759262
62Starch and sucrose metabolism_Homo sapiens_hsa005000.56949869
63Systemic lupus erythematosus_Homo sapiens_hsa053220.56752621
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.56087816
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54366589
66Basal cell carcinoma_Homo sapiens_hsa052170.53526503
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.49851694
68Sulfur metabolism_Homo sapiens_hsa009200.49104633
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.48550281
70Axon guidance_Homo sapiens_hsa043600.48505197
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47379904
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47029133
73Chemical carcinogenesis_Homo sapiens_hsa052040.46199796
74Autoimmune thyroid disease_Homo sapiens_hsa053200.45531065
75DNA replication_Homo sapiens_hsa030300.44504958
76Fat digestion and absorption_Homo sapiens_hsa049750.44372254
77Allograft rejection_Homo sapiens_hsa053300.41108591
78Nitrogen metabolism_Homo sapiens_hsa009100.40725455
79GABAergic synapse_Homo sapiens_hsa047270.40487115
80Dopaminergic synapse_Homo sapiens_hsa047280.39705430
81Hedgehog signaling pathway_Homo sapiens_hsa043400.39464849
82Long-term depression_Homo sapiens_hsa047300.39097153
83Glioma_Homo sapiens_hsa052140.38579262
84Cardiac muscle contraction_Homo sapiens_hsa042600.38009855
85Rheumatoid arthritis_Homo sapiens_hsa053230.37636590
86Purine metabolism_Homo sapiens_hsa002300.37621199
87Type I diabetes mellitus_Homo sapiens_hsa049400.36574475
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35396406
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35037878
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34757715
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32153341
92Circadian entrainment_Homo sapiens_hsa047130.31924383
93Measles_Homo sapiens_hsa051620.31689003
94Metabolic pathways_Homo sapiens_hsa011000.30765203
95Viral myocarditis_Homo sapiens_hsa054160.30649401
96Asthma_Homo sapiens_hsa053100.30589363
97Ovarian steroidogenesis_Homo sapiens_hsa049130.29347447
98Malaria_Homo sapiens_hsa051440.25476835
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25471122
100Non-small cell lung cancer_Homo sapiens_hsa052230.25032437

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