

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein neddylation (GO:0045116) | 5.05840674 |
| 2 | behavioral response to nicotine (GO:0035095) | 4.77196403 |
| 3 | DNA deamination (GO:0045006) | 4.72989980 |
| 4 | protein-cofactor linkage (GO:0018065) | 4.59907529 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.41458371 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.41458371 |
| 7 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.34439232 |
| 8 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.34439232 |
| 9 | protein complex biogenesis (GO:0070271) | 4.32107797 |
| 10 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.31141731 |
| 11 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.30631162 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 4.29723580 |
| 13 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.29697548 |
| 14 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.15553874 |
| 15 | NADH dehydrogenase complex assembly (GO:0010257) | 4.15553874 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.15553874 |
| 17 | ribosomal small subunit assembly (GO:0000028) | 4.05181395 |
| 18 | adenosine metabolic process (GO:0046085) | 4.04002318 |
| 19 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.00366070 |
| 20 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.93377541 |
| 21 | cytidine metabolic process (GO:0046087) | 3.90913276 |
| 22 | cytidine catabolic process (GO:0006216) | 3.90913276 |
| 23 | cytidine deamination (GO:0009972) | 3.90913276 |
| 24 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.81394811 |
| 25 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.72759780 |
| 26 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61587159 |
| 27 | rRNA modification (GO:0000154) | 3.59140456 |
| 28 | respiratory electron transport chain (GO:0022904) | 3.55679160 |
| 29 | electron transport chain (GO:0022900) | 3.55245478 |
| 30 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.54959508 |
| 31 | purine nucleotide salvage (GO:0032261) | 3.47728785 |
| 32 | viral transcription (GO:0019083) | 3.33610144 |
| 33 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.32298511 |
| 34 | hydrogen ion transmembrane transport (GO:1902600) | 3.29434191 |
| 35 | rRNA methylation (GO:0031167) | 3.27530075 |
| 36 | chromatin remodeling at centromere (GO:0031055) | 3.26724458 |
| 37 | translational termination (GO:0006415) | 3.25441857 |
| 38 | spliceosomal complex assembly (GO:0000245) | 3.20818995 |
| 39 | CENP-A containing nucleosome assembly (GO:0034080) | 3.15357922 |
| 40 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.10605760 |
| 41 | proton transport (GO:0015992) | 3.06403741 |
| 42 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.04470094 |
| 43 | RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) | 3.02053478 |
| 44 | platelet dense granule organization (GO:0060155) | 3.00613499 |
| 45 | hydrogen transport (GO:0006818) | 2.99951991 |
| 46 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.99160688 |
| 47 | proteasome assembly (GO:0043248) | 2.99154456 |
| 48 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.97414722 |
| 49 | termination of RNA polymerase III transcription (GO:0006386) | 2.97414722 |
| 50 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.92962378 |
| 51 | microtubule nucleation (GO:0007020) | 2.91192137 |
| 52 | translational elongation (GO:0006414) | 2.88916039 |
| 53 | inner mitochondrial membrane organization (GO:0007007) | 2.88784482 |
| 54 | cotranslational protein targeting to membrane (GO:0006613) | 2.88448882 |
| 55 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.88142299 |
| 56 | histone exchange (GO:0043486) | 2.87626987 |
| 57 | homocysteine metabolic process (GO:0050667) | 2.87465029 |
| 58 | protein targeting to ER (GO:0045047) | 2.87368563 |
| 59 | tRNA processing (GO:0008033) | 2.87230513 |
| 60 | tachykinin receptor signaling pathway (GO:0007217) | 2.83890415 |
| 61 | mitochondrial RNA metabolic process (GO:0000959) | 2.83239331 |
| 62 | cellular component biogenesis (GO:0044085) | 2.82340409 |
| 63 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.80301199 |
| 64 | tetrahydrofolate metabolic process (GO:0046653) | 2.79993865 |
| 65 | DNA ligation (GO:0006266) | 2.79728348 |
| 66 | maturation of SSU-rRNA (GO:0030490) | 2.79472459 |
| 67 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.79077555 |
| 68 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.79077555 |
| 69 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.79077555 |
| 70 | GTP biosynthetic process (GO:0006183) | 2.78016022 |
| 71 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.75823169 |
| 72 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.75823169 |
| 73 | piRNA metabolic process (GO:0034587) | 2.75426603 |
| 74 | meiotic chromosome segregation (GO:0045132) | 2.74325223 |
| 75 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.73921968 |
| 76 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.73921968 |
| 77 | isotype switching (GO:0045190) | 2.73921968 |
| 78 | pseudouridine synthesis (GO:0001522) | 2.73851863 |
| 79 | S-adenosylmethionine metabolic process (GO:0046500) | 2.70416052 |
| 80 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.70248065 |
| 81 | cytochrome complex assembly (GO:0017004) | 2.65393572 |
| 82 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.64909891 |
| 83 | protein localization to endoplasmic reticulum (GO:0070972) | 2.64386542 |
| 84 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.64079481 |
| 85 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.64079481 |
| 86 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.62852521 |
| 87 | DNA damage response, detection of DNA damage (GO:0042769) | 2.62454388 |
| 88 | rRNA catabolic process (GO:0016075) | 2.62216753 |
| 89 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.61685244 |
| 90 | L-fucose catabolic process (GO:0042355) | 2.61431416 |
| 91 | fucose catabolic process (GO:0019317) | 2.61431416 |
| 92 | L-fucose metabolic process (GO:0042354) | 2.61431416 |
| 93 | translation (GO:0006412) | 2.60378679 |
| 94 | rRNA metabolic process (GO:0016072) | 2.55893638 |
| 95 | ubiquinone biosynthetic process (GO:0006744) | 2.54862681 |
| 96 | cysteine metabolic process (GO:0006534) | 2.54660819 |
| 97 | rRNA processing (GO:0006364) | 2.54604563 |
| 98 | IMP biosynthetic process (GO:0006188) | 2.54465603 |
| 99 | L-methionine biosynthetic process (GO:0071265) | 2.53652723 |
| 100 | amino acid salvage (GO:0043102) | 2.53652723 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.81620248 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.37752897 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.96549466 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.76155754 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.63347338 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.30987857 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 3.29881697 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.10281724 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.81732484 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.57018047 |
| 11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30117038 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.21495428 |
| 13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.18926358 |
| 14 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.12105294 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.08050670 |
| 16 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.02320985 |
| 17 | EWS_26573619_Chip-Seq_HEK293_Human | 1.91840226 |
| 18 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.83221524 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.80957143 |
| 20 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.79876807 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.77998546 |
| 22 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.77357530 |
| 23 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.76053171 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.71801251 |
| 25 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.61852805 |
| 26 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.61690231 |
| 27 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.58722399 |
| 28 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.57556090 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.53892951 |
| 30 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.52133698 |
| 31 | P300_19829295_ChIP-Seq_ESCs_Human | 1.44954747 |
| 32 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.43334139 |
| 33 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.43334139 |
| 34 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.43104139 |
| 35 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.37860520 |
| 36 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.33376159 |
| 37 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.33252783 |
| 38 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.32718028 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.32034451 |
| 40 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.31092574 |
| 41 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.27347270 |
| 42 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.27124309 |
| 43 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.26570054 |
| 44 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.26192311 |
| 45 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.26192311 |
| 46 | NCOR_22424771_ChIP-Seq_293T_Human | 1.24527216 |
| 47 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.24516032 |
| 48 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.22894226 |
| 49 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.21396750 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.20318422 |
| 51 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.17866252 |
| 52 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.17297394 |
| 53 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.16260324 |
| 54 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.13934855 |
| 55 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.13568817 |
| 56 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.13438772 |
| 57 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.12298007 |
| 58 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.12298007 |
| 59 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.12284543 |
| 60 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.11155396 |
| 61 | GATA3_26560356_Chip-Seq_TH2_Human | 1.08272581 |
| 62 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.07869403 |
| 63 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.07567114 |
| 64 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.04039650 |
| 65 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.01983216 |
| 66 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.01019960 |
| 67 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.00949343 |
| 68 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.99425127 |
| 69 | REST_21632747_ChIP-Seq_MESCs_Mouse | 0.99205554 |
| 70 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.99057673 |
| 71 | AR_20517297_ChIP-Seq_VCAP_Human | 0.98878960 |
| 72 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.98859913 |
| 73 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.98367504 |
| 74 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.97683022 |
| 75 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.94729266 |
| 76 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.94695868 |
| 77 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.94407884 |
| 78 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.94182482 |
| 79 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.94070499 |
| 80 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.93125320 |
| 81 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92678556 |
| 82 | FUS_26573619_Chip-Seq_HEK293_Human | 0.92189164 |
| 83 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.92146365 |
| 84 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.92066904 |
| 85 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.91451411 |
| 86 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.89443207 |
| 87 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.89004348 |
| 88 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88928908 |
| 89 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.88202102 |
| 90 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.87561847 |
| 91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.87070877 |
| 92 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.86294111 |
| 93 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.85797435 |
| 94 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.85099724 |
| 95 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.84910692 |
| 96 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.84315528 |
| 97 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.84047678 |
| 98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.84040662 |
| 99 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.83894399 |
| 100 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.82481073 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003183_abnormal_peptide_metabolism | 3.35042707 |
| 2 | MP0008877_abnormal_DNA_methylation | 2.94464795 |
| 3 | MP0005646_abnormal_pituitary_gland | 2.79600048 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.51637631 |
| 5 | MP0005075_abnormal_melanosome_morpholog | 2.51009504 |
| 6 | MP0004885_abnormal_endolymph | 2.42582273 |
| 7 | MP0006292_abnormal_olfactory_placode | 2.41379940 |
| 8 | MP0008872_abnormal_physiological_respon | 2.39767209 |
| 9 | MP0002163_abnormal_gland_morphology | 2.39356254 |
| 10 | MP0004147_increased_porphyrin_level | 2.27299624 |
| 11 | MP0002876_abnormal_thyroid_physiology | 2.16837707 |
| 12 | MP0001835_abnormal_antigen_presentation | 2.14046753 |
| 13 | MP0003195_calcinosis | 1.98988078 |
| 14 | MP0005551_abnormal_eye_electrophysiolog | 1.93252723 |
| 15 | MP0008875_abnormal_xenobiotic_pharmacok | 1.93190664 |
| 16 | MP0005360_urolithiasis | 1.93038410 |
| 17 | MP0009379_abnormal_foot_pigmentation | 1.82575137 |
| 18 | MP0002938_white_spotting | 1.80829192 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 1.79527520 |
| 20 | MP0002102_abnormal_ear_morphology | 1.76463000 |
| 21 | MP0003787_abnormal_imprinting | 1.73292711 |
| 22 | MP0003646_muscle_fatigue | 1.71806567 |
| 23 | MP0000372_irregular_coat_pigmentation | 1.70980462 |
| 24 | MP0008995_early_reproductive_senescence | 1.70281361 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 1.70156604 |
| 26 | MP0002736_abnormal_nociception_after | 1.69045449 |
| 27 | MP0005253_abnormal_eye_physiology | 1.65478175 |
| 28 | MP0002095_abnormal_skin_pigmentation | 1.62539312 |
| 29 | MP0005671_abnormal_response_to | 1.56914534 |
| 30 | MP0008789_abnormal_olfactory_epithelium | 1.49061374 |
| 31 | MP0002272_abnormal_nervous_system | 1.47548430 |
| 32 | MP0001919_abnormal_reproductive_system | 1.47417675 |
| 33 | MP0001968_abnormal_touch/_nociception | 1.46109410 |
| 34 | MP0003011_delayed_dark_adaptation | 1.45894267 |
| 35 | MP0005379_endocrine/exocrine_gland_phen | 1.36062394 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.34093098 |
| 37 | MP0004142_abnormal_muscle_tone | 1.33239309 |
| 38 | MP0005389_reproductive_system_phenotype | 1.30360207 |
| 39 | MP0001485_abnormal_pinna_reflex | 1.30192047 |
| 40 | MP0003880_abnormal_central_pattern | 1.26526569 |
| 41 | MP0005084_abnormal_gallbladder_morpholo | 1.25033877 |
| 42 | MP0005332_abnormal_amino_acid | 1.24121993 |
| 43 | MP0000631_abnormal_neuroendocrine_gland | 1.22658261 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.22023580 |
| 45 | MP0000685_abnormal_immune_system | 1.20871415 |
| 46 | MP0009745_abnormal_behavioral_response | 1.18976965 |
| 47 | MP0001986_abnormal_taste_sensitivity | 1.18758640 |
| 48 | MP0004043_abnormal_pH_regulation | 1.17055668 |
| 49 | MP0004742_abnormal_vestibular_system | 1.16137061 |
| 50 | MP0001800_abnormal_humoral_immune | 1.14942563 |
| 51 | MP0003718_maternal_effect | 1.14109483 |
| 52 | MP0003786_premature_aging | 1.13845698 |
| 53 | MP0002138_abnormal_hepatobiliary_system | 1.10630980 |
| 54 | MP0000015_abnormal_ear_pigmentation | 1.07937103 |
| 55 | MP0001905_abnormal_dopamine_level | 1.07919792 |
| 56 | MP0005174_abnormal_tail_pigmentation | 1.07326228 |
| 57 | MP0002210_abnormal_sex_determination | 1.06720600 |
| 58 | MP0000013_abnormal_adipose_tissue | 1.05682223 |
| 59 | MP0010094_abnormal_chromosome_stability | 1.05407950 |
| 60 | MP0004133_heterotaxia | 1.04374512 |
| 61 | MP0005647_abnormal_sex_gland | 1.03789630 |
| 62 | MP0003186_abnormal_redox_activity | 1.01855453 |
| 63 | MP0000026_abnormal_inner_ear | 1.01756263 |
| 64 | MP0002160_abnormal_reproductive_system | 1.00519134 |
| 65 | MP0003252_abnormal_bile_duct | 1.00016027 |
| 66 | MP0002735_abnormal_chemical_nociception | 0.99376664 |
| 67 | MP0005167_abnormal_blood-brain_barrier | 0.99150503 |
| 68 | MP0005394_taste/olfaction_phenotype | 0.99095781 |
| 69 | MP0005499_abnormal_olfactory_system | 0.99095781 |
| 70 | MP0001486_abnormal_startle_reflex | 0.96929378 |
| 71 | MP0001984_abnormal_olfaction | 0.96739323 |
| 72 | MP0002277_abnormal_respiratory_mucosa | 0.95896846 |
| 73 | MP0001324_abnormal_eye_pigmentation | 0.94591368 |
| 74 | MP0002572_abnormal_emotion/affect_behav | 0.91557709 |
| 75 | MP0002234_abnormal_pharynx_morphology | 0.91266472 |
| 76 | MP0001764_abnormal_homeostasis | 0.90793955 |
| 77 | MP0008058_abnormal_DNA_repair | 0.89595739 |
| 78 | MP0005410_abnormal_fertilization | 0.88884445 |
| 79 | MP0005377_hearing/vestibular/ear_phenot | 0.88348327 |
| 80 | MP0003878_abnormal_ear_physiology | 0.88348327 |
| 81 | MP0002148_abnormal_hypersensitivity_rea | 0.87840905 |
| 82 | MP0001529_abnormal_vocalization | 0.87186280 |
| 83 | MP0009764_decreased_sensitivity_to | 0.84927832 |
| 84 | MP0002653_abnormal_ependyma_morphology | 0.84588136 |
| 85 | MP0000230_abnormal_systemic_arterial | 0.84579970 |
| 86 | MP0002282_abnormal_trachea_morphology | 0.83201096 |
| 87 | MP0001929_abnormal_gametogenesis | 0.83039261 |
| 88 | MP0001119_abnormal_female_reproductive | 0.81688298 |
| 89 | MP0001873_stomach_inflammation | 0.80884260 |
| 90 | MP0001145_abnormal_male_reproductive | 0.80341061 |
| 91 | MP0000653_abnormal_sex_gland | 0.80074189 |
| 92 | MP0005195_abnormal_posterior_eye | 0.79071447 |
| 93 | MP0001440_abnormal_grooming_behavior | 0.78592922 |
| 94 | MP0005636_abnormal_mineral_homeostasis | 0.78447894 |
| 95 | MP0001293_anophthalmia | 0.78086760 |
| 96 | MP0003724_increased_susceptibility_to | 0.77525409 |
| 97 | MP0002928_abnormal_bile_duct | 0.76903107 |
| 98 | MP0003283_abnormal_digestive_organ | 0.75849640 |
| 99 | MP0001970_abnormal_pain_threshold | 0.74962211 |
| 100 | MP0001790_abnormal_immune_system | 0.74496006 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 4.40704860 |
| 2 | Abnormality of alanine metabolism (HP:0010916) | 4.40704860 |
| 3 | Hyperalaninemia (HP:0003348) | 4.40704860 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 4.10070205 |
| 5 | Abnormality of the labia minora (HP:0012880) | 3.71811936 |
| 6 | Acute encephalopathy (HP:0006846) | 3.60789634 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.58457909 |
| 8 | Molar tooth sign on MRI (HP:0002419) | 3.52852090 |
| 9 | Abnormality of midbrain morphology (HP:0002418) | 3.52852090 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.48283068 |
| 11 | Congenital stationary night blindness (HP:0007642) | 3.46734512 |
| 12 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.42689583 |
| 13 | Progressive macrocephaly (HP:0004481) | 3.40009568 |
| 14 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.39867491 |
| 15 | Abolished electroretinogram (ERG) (HP:0000550) | 3.36075311 |
| 16 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.24766664 |
| 17 | Increased CSF lactate (HP:0002490) | 3.20661576 |
| 18 | Constricted visual fields (HP:0001133) | 3.14311951 |
| 19 | Attenuation of retinal blood vessels (HP:0007843) | 3.00967806 |
| 20 | Optic disc pallor (HP:0000543) | 2.92795036 |
| 21 | Hepatocellular necrosis (HP:0001404) | 2.90412930 |
| 22 | IgG deficiency (HP:0004315) | 2.89229897 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 2.88366276 |
| 24 | Dyschromatopsia (HP:0007641) | 2.85216921 |
| 25 | Cerebral edema (HP:0002181) | 2.77687133 |
| 26 | Pigmentary retinal degeneration (HP:0001146) | 2.71357514 |
| 27 | Tubulointerstitial nephritis (HP:0001970) | 2.65071304 |
| 28 | Hepatic necrosis (HP:0002605) | 2.61396540 |
| 29 | Nephronophthisis (HP:0000090) | 2.61305405 |
| 30 | Pancreatic cysts (HP:0001737) | 2.54028877 |
| 31 | Increased hepatocellular lipid droplets (HP:0006565) | 2.53319992 |
| 32 | Methylmalonic acidemia (HP:0002912) | 2.53076258 |
| 33 | Hypomagnesemia (HP:0002917) | 2.52870399 |
| 34 | Decreased central vision (HP:0007663) | 2.51020538 |
| 35 | Congenital, generalized hypertrichosis (HP:0004540) | 2.45821246 |
| 36 | Increased serum lactate (HP:0002151) | 2.45255751 |
| 37 | Congenital sensorineural hearing impairment (HP:0008527) | 2.42623068 |
| 38 | Medial flaring of the eyebrow (HP:0010747) | 2.41014474 |
| 39 | Type II lissencephaly (HP:0007260) | 2.39823359 |
| 40 | Lipid accumulation in hepatocytes (HP:0006561) | 2.38250684 |
| 41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.37598149 |
| 42 | Lactic acidosis (HP:0003128) | 2.35894710 |
| 43 | Septo-optic dysplasia (HP:0100842) | 2.35717196 |
| 44 | Pancreatic fibrosis (HP:0100732) | 2.35102715 |
| 45 | Hyperglycinemia (HP:0002154) | 2.34711510 |
| 46 | Abnormality of magnesium homeostasis (HP:0004921) | 2.33335969 |
| 47 | Maternal diabetes (HP:0009800) | 2.27900127 |
| 48 | Large eyes (HP:0001090) | 2.26815032 |
| 49 | True hermaphroditism (HP:0010459) | 2.19000476 |
| 50 | Abnormality of serum amino acid levels (HP:0003112) | 2.18322242 |
| 51 | Methylmalonic aciduria (HP:0012120) | 2.17641518 |
| 52 | Abnormality of homocysteine metabolism (HP:0010919) | 2.14409806 |
| 53 | Homocystinuria (HP:0002156) | 2.14409806 |
| 54 | Pendular nystagmus (HP:0012043) | 2.13163569 |
| 55 | Lethargy (HP:0001254) | 2.11399333 |
| 56 | Renal cortical cysts (HP:0000803) | 2.10205684 |
| 57 | Abnormality of the prostate (HP:0008775) | 2.09988022 |
| 58 | Abnormality of the renal medulla (HP:0100957) | 2.09492841 |
| 59 | Absent thumb (HP:0009777) | 2.07337289 |
| 60 | Panhypogammaglobulinemia (HP:0003139) | 2.06489071 |
| 61 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.05995275 |
| 62 | Anencephaly (HP:0002323) | 2.05025287 |
| 63 | Birth length less than 3rd percentile (HP:0003561) | 2.00512767 |
| 64 | Abnormality of the renal cortex (HP:0011035) | 2.00232672 |
| 65 | Cerebellar dysplasia (HP:0007033) | 1.98808483 |
| 66 | Anorexia (HP:0002039) | 1.93242502 |
| 67 | Absent septum pellucidum (HP:0001331) | 1.92722909 |
| 68 | Tetany (HP:0001281) | 1.91140740 |
| 69 | Asplenia (HP:0001746) | 1.88249467 |
| 70 | Renal Fanconi syndrome (HP:0001994) | 1.88239328 |
| 71 | Stomatitis (HP:0010280) | 1.87864495 |
| 72 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.85907097 |
| 73 | Adactyly (HP:0009776) | 1.85127353 |
| 74 | Sclerocornea (HP:0000647) | 1.84718840 |
| 75 | Hypoproteinemia (HP:0003075) | 1.83844662 |
| 76 | Lissencephaly (HP:0001339) | 1.80794587 |
| 77 | Hyperglycinuria (HP:0003108) | 1.78449611 |
| 78 | Severe combined immunodeficiency (HP:0004430) | 1.77798946 |
| 79 | Chronic sinusitis (HP:0011109) | 1.76842095 |
| 80 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.76358731 |
| 81 | Nephrogenic diabetes insipidus (HP:0009806) | 1.74726673 |
| 82 | Increased intramyocellular lipid droplets (HP:0012240) | 1.74382560 |
| 83 | Poor speech (HP:0002465) | 1.74248450 |
| 84 | Disproportionate short-trunk short stature (HP:0003521) | 1.73281538 |
| 85 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.72864878 |
| 86 | Macrocytic anemia (HP:0001972) | 1.71880239 |
| 87 | Exertional dyspnea (HP:0002875) | 1.71570070 |
| 88 | Abnormality of glycine metabolism (HP:0010895) | 1.71487522 |
| 89 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.71487522 |
| 90 | Respiratory failure (HP:0002878) | 1.70727347 |
| 91 | Abnormality of B cell number (HP:0010975) | 1.70703492 |
| 92 | Metabolic acidosis (HP:0001942) | 1.69349375 |
| 93 | Cerebral hypomyelination (HP:0006808) | 1.69102764 |
| 94 | Growth hormone deficiency (HP:0000824) | 1.68243287 |
| 95 | Leukodystrophy (HP:0002415) | 1.65445350 |
| 96 | B lymphocytopenia (HP:0010976) | 1.65216892 |
| 97 | Rib fusion (HP:0000902) | 1.62604930 |
| 98 | Ketoacidosis (HP:0001993) | 1.62548881 |
| 99 | Supernumerary spleens (HP:0009799) | 1.62380803 |
| 100 | Hypoplasia of the radius (HP:0002984) | 1.61733983 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TAOK3 | 3.85709159 |
| 2 | TXK | 3.49916962 |
| 3 | WNK3 | 3.37273728 |
| 4 | MAP4K2 | 2.95064446 |
| 5 | ADRBK2 | 2.89888083 |
| 6 | WNK4 | 2.86894933 |
| 7 | PLK4 | 2.70383732 |
| 8 | VRK2 | 2.58206869 |
| 9 | NUAK1 | 2.56621388 |
| 10 | FRK | 2.25763161 |
| 11 | ZAK | 1.97253043 |
| 12 | MST4 | 1.94442928 |
| 13 | GRK1 | 1.91840440 |
| 14 | CDK19 | 1.91216127 |
| 15 | MAP3K12 | 1.80753989 |
| 16 | STK39 | 1.72720893 |
| 17 | TAF1 | 1.72132811 |
| 18 | BMPR1B | 1.71098777 |
| 19 | TLK1 | 1.69109023 |
| 20 | BMPR2 | 1.65026423 |
| 21 | ACVR1B | 1.60128927 |
| 22 | OXSR1 | 1.58096945 |
| 23 | CDK8 | 1.47961947 |
| 24 | VRK1 | 1.40626217 |
| 25 | TIE1 | 1.39040431 |
| 26 | EIF2AK3 | 1.38903315 |
| 27 | MAP4K1 | 1.35948801 |
| 28 | KIT | 1.22181398 |
| 29 | MKNK2 | 1.16844159 |
| 30 | BCKDK | 1.16199866 |
| 31 | PINK1 | 1.14605921 |
| 32 | DYRK2 | 1.13345904 |
| 33 | TSSK6 | 1.10526594 |
| 34 | PLK3 | 1.06474805 |
| 35 | MKNK1 | 1.04211480 |
| 36 | MUSK | 0.98364933 |
| 37 | TYRO3 | 0.92555538 |
| 38 | TNIK | 0.88827547 |
| 39 | NEK1 | 0.88304188 |
| 40 | CSF1R | 0.88164129 |
| 41 | KDR | 0.85839575 |
| 42 | GRK6 | 0.84618616 |
| 43 | STK16 | 0.84410239 |
| 44 | NTRK2 | 0.81289067 |
| 45 | SYK | 0.78208365 |
| 46 | TNK2 | 0.76207805 |
| 47 | BUB1 | 0.75372629 |
| 48 | ADRBK1 | 0.74399898 |
| 49 | NME1 | 0.74275093 |
| 50 | PLK2 | 0.73263251 |
| 51 | DAPK2 | 0.71948044 |
| 52 | PRKCG | 0.71562005 |
| 53 | FES | 0.71430407 |
| 54 | IKBKB | 0.70931078 |
| 55 | CDC7 | 0.70235956 |
| 56 | EPHB2 | 0.68563953 |
| 57 | TEC | 0.68454395 |
| 58 | NEK2 | 0.68208586 |
| 59 | CCNB1 | 0.64810682 |
| 60 | WEE1 | 0.64539247 |
| 61 | INSRR | 0.63996229 |
| 62 | IRAK4 | 0.63771918 |
| 63 | PRKCH | 0.58506164 |
| 64 | SGK494 | 0.58463321 |
| 65 | SGK223 | 0.58463321 |
| 66 | PRKCQ | 0.57849499 |
| 67 | EIF2AK2 | 0.56035446 |
| 68 | ITK | 0.55933734 |
| 69 | MAP3K4 | 0.55770023 |
| 70 | PLK1 | 0.54606441 |
| 71 | EIF2AK1 | 0.52274864 |
| 72 | ATR | 0.50608315 |
| 73 | PASK | 0.50397895 |
| 74 | ERBB3 | 0.50305460 |
| 75 | CSNK2A2 | 0.48680359 |
| 76 | DAPK1 | 0.48616097 |
| 77 | AURKB | 0.46953349 |
| 78 | CHEK2 | 0.46949870 |
| 79 | MATK | 0.45674350 |
| 80 | DAPK3 | 0.42393116 |
| 81 | PRKACA | 0.42036405 |
| 82 | FLT3 | 0.41654360 |
| 83 | PRKCI | 0.40636161 |
| 84 | CSNK2A1 | 0.40601197 |
| 85 | MARK1 | 0.40517151 |
| 86 | WNK1 | 0.40204898 |
| 87 | PNCK | 0.38775082 |
| 88 | LYN | 0.37878208 |
| 89 | CAMKK2 | 0.37538135 |
| 90 | CDK9 | 0.37515399 |
| 91 | GRK5 | 0.36651283 |
| 92 | OBSCN | 0.36377283 |
| 93 | IGF1R | 0.34936702 |
| 94 | CAMK2A | 0.33927503 |
| 95 | PHKG2 | 0.32851974 |
| 96 | PHKG1 | 0.32851974 |
| 97 | PRKCA | 0.32803871 |
| 98 | MINK1 | 0.31479053 |
| 99 | ALK | 0.31269754 |
| 100 | CDK7 | 0.31078531 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.72760144 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.62050530 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.29811033 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.84640970 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.69929453 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.44286438 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.34883118 |
| 8 | Asthma_Homo sapiens_hsa05310 | 2.18850084 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.14205196 |
| 10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.06364525 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.03737241 |
| 12 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.00704645 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.97233507 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.93548411 |
| 15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.90320268 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.88966492 |
| 17 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.81239089 |
| 18 | DNA replication_Homo sapiens_hsa03030 | 1.77653722 |
| 19 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.76221256 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.73091687 |
| 21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.71206735 |
| 22 | Allograft rejection_Homo sapiens_hsa05330 | 1.70677242 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.66220856 |
| 24 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.65990003 |
| 25 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.62812377 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.60639209 |
| 27 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.53748482 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.45445495 |
| 29 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.45044883 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.40386969 |
| 31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.39574514 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.38774268 |
| 33 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.31692306 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27331728 |
| 35 | Nicotine addiction_Homo sapiens_hsa05033 | 1.24141016 |
| 36 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.23695341 |
| 37 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.22662353 |
| 38 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.22155720 |
| 39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.18278861 |
| 40 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.17954052 |
| 41 | RNA transport_Homo sapiens_hsa03013 | 1.14541566 |
| 42 | Base excision repair_Homo sapiens_hsa03410 | 1.12957872 |
| 43 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.11419068 |
| 44 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.08934102 |
| 45 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.08278249 |
| 46 | Spliceosome_Homo sapiens_hsa03040 | 1.04796505 |
| 47 | Peroxisome_Homo sapiens_hsa04146 | 0.98089133 |
| 48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.97578455 |
| 49 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.97451205 |
| 50 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.95530356 |
| 51 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.93195467 |
| 52 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.91808483 |
| 53 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.89485988 |
| 54 | Purine metabolism_Homo sapiens_hsa00230 | 0.88862549 |
| 55 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.87823505 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.87122926 |
| 57 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.86750845 |
| 58 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.86446496 |
| 59 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.84411423 |
| 60 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.76642190 |
| 61 | Morphine addiction_Homo sapiens_hsa05032 | 0.73986796 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.71835721 |
| 63 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.71069555 |
| 64 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.69143445 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.69066579 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.67930463 |
| 67 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.67066462 |
| 68 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.66766412 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.65546688 |
| 70 | Olfactory transduction_Homo sapiens_hsa04740 | 0.63890035 |
| 71 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.63185452 |
| 72 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62264999 |
| 73 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.60844417 |
| 74 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.60622651 |
| 75 | GABAergic synapse_Homo sapiens_hsa04727 | 0.60501668 |
| 76 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.57136760 |
| 77 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.56961528 |
| 78 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.56291772 |
| 79 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.54832623 |
| 80 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.52290113 |
| 81 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.49729435 |
| 82 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.49248710 |
| 83 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.48795069 |
| 84 | Taste transduction_Homo sapiens_hsa04742 | 0.43842286 |
| 85 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.43085902 |
| 86 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40759750 |
| 87 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.39132729 |
| 88 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38253965 |
| 89 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.37479454 |
| 90 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.34125011 |
| 91 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.31983165 |
| 92 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.31594319 |
| 93 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.29078605 |
| 94 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.28456319 |
| 95 | Salivary secretion_Homo sapiens_hsa04970 | 0.28430223 |
| 96 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26019307 |
| 97 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.25261510 |
| 98 | Circadian entrainment_Homo sapiens_hsa04713 | 0.24781774 |
| 99 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.23064838 |
| 100 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.22525054 |

