HMGB1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.05840674
2behavioral response to nicotine (GO:0035095)4.77196403
3DNA deamination (GO:0045006)4.72989980
4protein-cofactor linkage (GO:0018065)4.59907529
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41458371
6ATP synthesis coupled proton transport (GO:0015986)4.41458371
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.34439232
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.34439232
9protein complex biogenesis (GO:0070271)4.32107797
10folic acid-containing compound biosynthetic process (GO:0009396)4.31141731
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.30631162
12chaperone-mediated protein transport (GO:0072321)4.29723580
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29697548
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.15553874
15NADH dehydrogenase complex assembly (GO:0010257)4.15553874
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15553874
17ribosomal small subunit assembly (GO:0000028)4.05181395
18adenosine metabolic process (GO:0046085)4.04002318
19mitochondrial respiratory chain complex assembly (GO:0033108)4.00366070
20water-soluble vitamin biosynthetic process (GO:0042364)3.93377541
21cytidine metabolic process (GO:0046087)3.90913276
22cytidine catabolic process (GO:0006216)3.90913276
23cytidine deamination (GO:0009972)3.90913276
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81394811
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72759780
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61587159
27rRNA modification (GO:0000154)3.59140456
28respiratory electron transport chain (GO:0022904)3.55679160
29electron transport chain (GO:0022900)3.55245478
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54959508
31purine nucleotide salvage (GO:0032261)3.47728785
32viral transcription (GO:0019083)3.33610144
33pyrimidine ribonucleoside catabolic process (GO:0046133)3.32298511
34hydrogen ion transmembrane transport (GO:1902600)3.29434191
35rRNA methylation (GO:0031167)3.27530075
36chromatin remodeling at centromere (GO:0031055)3.26724458
37translational termination (GO:0006415)3.25441857
38spliceosomal complex assembly (GO:0000245)3.20818995
39CENP-A containing nucleosome assembly (GO:0034080)3.15357922
40pteridine-containing compound biosynthetic process (GO:0042559)3.10605760
41proton transport (GO:0015992)3.06403741
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04470094
43RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.02053478
44platelet dense granule organization (GO:0060155)3.00613499
45hydrogen transport (GO:0006818)2.99951991
46regulation of cellular amino acid metabolic process (GO:0006521)2.99160688
47proteasome assembly (GO:0043248)2.99154456
48transcription elongation from RNA polymerase III promoter (GO:0006385)2.97414722
49termination of RNA polymerase III transcription (GO:0006386)2.97414722
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92962378
51microtubule nucleation (GO:0007020)2.91192137
52translational elongation (GO:0006414)2.88916039
53inner mitochondrial membrane organization (GO:0007007)2.88784482
54cotranslational protein targeting to membrane (GO:0006613)2.88448882
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88142299
56histone exchange (GO:0043486)2.87626987
57homocysteine metabolic process (GO:0050667)2.87465029
58protein targeting to ER (GO:0045047)2.87368563
59tRNA processing (GO:0008033)2.87230513
60tachykinin receptor signaling pathway (GO:0007217)2.83890415
61mitochondrial RNA metabolic process (GO:0000959)2.83239331
62cellular component biogenesis (GO:0044085)2.82340409
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80301199
64tetrahydrofolate metabolic process (GO:0046653)2.79993865
65DNA ligation (GO:0006266)2.79728348
66maturation of SSU-rRNA (GO:0030490)2.79472459
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79077555
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79077555
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79077555
70GTP biosynthetic process (GO:0006183)2.78016022
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75823169
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75823169
73piRNA metabolic process (GO:0034587)2.75426603
74meiotic chromosome segregation (GO:0045132)2.74325223
75somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73921968
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73921968
77isotype switching (GO:0045190)2.73921968
78pseudouridine synthesis (GO:0001522)2.73851863
79S-adenosylmethionine metabolic process (GO:0046500)2.70416052
80establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70248065
81cytochrome complex assembly (GO:0017004)2.65393572
82preassembly of GPI anchor in ER membrane (GO:0016254)2.64909891
83protein localization to endoplasmic reticulum (GO:0070972)2.64386542
84signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64079481
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.64079481
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62852521
87DNA damage response, detection of DNA damage (GO:0042769)2.62454388
88rRNA catabolic process (GO:0016075)2.62216753
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.61685244
90L-fucose catabolic process (GO:0042355)2.61431416
91fucose catabolic process (GO:0019317)2.61431416
92L-fucose metabolic process (GO:0042354)2.61431416
93translation (GO:0006412)2.60378679
94rRNA metabolic process (GO:0016072)2.55893638
95ubiquinone biosynthetic process (GO:0006744)2.54862681
96cysteine metabolic process (GO:0006534)2.54660819
97rRNA processing (GO:0006364)2.54604563
98IMP biosynthetic process (GO:0006188)2.54465603
99L-methionine biosynthetic process (GO:0071265)2.53652723
100amino acid salvage (GO:0043102)2.53652723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81620248
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.37752897
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.96549466
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76155754
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.63347338
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30987857
7VDR_22108803_ChIP-Seq_LS180_Human3.29881697
8ZNF274_21170338_ChIP-Seq_K562_Hela3.10281724
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81732484
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57018047
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30117038
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.21495428
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18926358
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.12105294
15VDR_23849224_ChIP-Seq_CD4+_Human2.08050670
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02320985
17EWS_26573619_Chip-Seq_HEK293_Human1.91840226
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83221524
19FOXP3_21729870_ChIP-Seq_TREG_Human1.80957143
20ELK1_19687146_ChIP-ChIP_HELA_Human1.79876807
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77998546
22TP53_22573176_ChIP-Seq_HFKS_Human1.77357530
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76053171
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71801251
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61852805
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61690231
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.58722399
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.57556090
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.53892951
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.52133698
31P300_19829295_ChIP-Seq_ESCs_Human1.44954747
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.43334139
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43334139
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43104139
35MYC_18940864_ChIP-ChIP_HL60_Human1.37860520
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.33376159
37IRF1_19129219_ChIP-ChIP_H3396_Human1.33252783
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32718028
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32034451
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31092574
41ER_23166858_ChIP-Seq_MCF-7_Human1.27347270
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.27124309
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26570054
44NANOG_19829295_ChIP-Seq_ESCs_Human1.26192311
45SOX2_19829295_ChIP-Seq_ESCs_Human1.26192311
46NCOR_22424771_ChIP-Seq_293T_Human1.24527216
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24516032
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22894226
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21396750
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.20318422
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17866252
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17297394
53TTF2_22483619_ChIP-Seq_HELA_Human1.16260324
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13934855
55GBX2_23144817_ChIP-Seq_PC3_Human1.13568817
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.13438772
57CBP_20019798_ChIP-Seq_JUKART_Human1.12298007
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12298007
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12284543
60IGF1R_20145208_ChIP-Seq_DFB_Human1.11155396
61GATA3_26560356_Chip-Seq_TH2_Human1.08272581
62BCAT_22108803_ChIP-Seq_LS180_Human1.07869403
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07567114
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04039650
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01983216
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01019960
67TAF2_19829295_ChIP-Seq_ESCs_Human1.00949343
68FOXH1_21741376_ChIP-Seq_ESCs_Human0.99425127
69REST_21632747_ChIP-Seq_MESCs_Mouse0.99205554
70POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99057673
71AR_20517297_ChIP-Seq_VCAP_Human0.98878960
72MYC_19829295_ChIP-Seq_ESCs_Human0.98859913
73GABP_19822575_ChIP-Seq_HepG2_Human0.98367504
74TAF15_26573619_Chip-Seq_HEK293_Human0.97683022
75YY1_22570637_ChIP-Seq_MALME-3M_Human0.94729266
76FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94695868
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94407884
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94182482
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94070499
80CDX2_22108803_ChIP-Seq_LS180_Human0.93125320
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92678556
82FUS_26573619_Chip-Seq_HEK293_Human0.92189164
83HOXB7_26014856_ChIP-Seq_BT474_Human0.92146365
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92066904
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91451411
86ERG_20517297_ChIP-Seq_VCAP_Human0.89443207
87NANOG_20526341_ChIP-Seq_ESCs_Human0.89004348
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88928908
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.88202102
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87561847
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87070877
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86294111
93P53_21459846_ChIP-Seq_SAOS-2_Human0.85797435
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.85099724
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84910692
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84315528
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84047678
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84040662
99TCF4_22108803_ChIP-Seq_LS180_Human0.83894399
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.82481073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.35042707
2MP0008877_abnormal_DNA_methylation2.94464795
3MP0005646_abnormal_pituitary_gland2.79600048
4MP0006072_abnormal_retinal_apoptosis2.51637631
5MP0005075_abnormal_melanosome_morpholog2.51009504
6MP0004885_abnormal_endolymph2.42582273
7MP0006292_abnormal_olfactory_placode2.41379940
8MP0008872_abnormal_physiological_respon2.39767209
9MP0002163_abnormal_gland_morphology2.39356254
10MP0004147_increased_porphyrin_level2.27299624
11MP0002876_abnormal_thyroid_physiology2.16837707
12MP0001835_abnormal_antigen_presentation2.14046753
13MP0003195_calcinosis1.98988078
14MP0005551_abnormal_eye_electrophysiolog1.93252723
15MP0008875_abnormal_xenobiotic_pharmacok1.93190664
16MP0005360_urolithiasis1.93038410
17MP0009379_abnormal_foot_pigmentation1.82575137
18MP0002938_white_spotting1.80829192
19MP0003806_abnormal_nucleotide_metabolis1.79527520
20MP0002102_abnormal_ear_morphology1.76463000
21MP0003787_abnormal_imprinting1.73292711
22MP0003646_muscle_fatigue1.71806567
23MP0000372_irregular_coat_pigmentation1.70980462
24MP0008995_early_reproductive_senescence1.70281361
25MP0005645_abnormal_hypothalamus_physiol1.70156604
26MP0002736_abnormal_nociception_after1.69045449
27MP0005253_abnormal_eye_physiology1.65478175
28MP0002095_abnormal_skin_pigmentation1.62539312
29MP0005671_abnormal_response_to1.56914534
30MP0008789_abnormal_olfactory_epithelium1.49061374
31MP0002272_abnormal_nervous_system1.47548430
32MP0001919_abnormal_reproductive_system1.47417675
33MP0001968_abnormal_touch/_nociception1.46109410
34MP0003011_delayed_dark_adaptation1.45894267
35MP0005379_endocrine/exocrine_gland_phen1.36062394
36MP0002837_dystrophic_cardiac_calcinosis1.34093098
37MP0004142_abnormal_muscle_tone1.33239309
38MP0005389_reproductive_system_phenotype1.30360207
39MP0001485_abnormal_pinna_reflex1.30192047
40MP0003880_abnormal_central_pattern1.26526569
41MP0005084_abnormal_gallbladder_morpholo1.25033877
42MP0005332_abnormal_amino_acid1.24121993
43MP0000631_abnormal_neuroendocrine_gland1.22658261
44MP0006276_abnormal_autonomic_nervous1.22023580
45MP0000685_abnormal_immune_system1.20871415
46MP0009745_abnormal_behavioral_response1.18976965
47MP0001986_abnormal_taste_sensitivity1.18758640
48MP0004043_abnormal_pH_regulation1.17055668
49MP0004742_abnormal_vestibular_system1.16137061
50MP0001800_abnormal_humoral_immune1.14942563
51MP0003718_maternal_effect1.14109483
52MP0003786_premature_aging1.13845698
53MP0002138_abnormal_hepatobiliary_system1.10630980
54MP0000015_abnormal_ear_pigmentation1.07937103
55MP0001905_abnormal_dopamine_level1.07919792
56MP0005174_abnormal_tail_pigmentation1.07326228
57MP0002210_abnormal_sex_determination1.06720600
58MP0000013_abnormal_adipose_tissue1.05682223
59MP0010094_abnormal_chromosome_stability1.05407950
60MP0004133_heterotaxia1.04374512
61MP0005647_abnormal_sex_gland1.03789630
62MP0003186_abnormal_redox_activity1.01855453
63MP0000026_abnormal_inner_ear1.01756263
64MP0002160_abnormal_reproductive_system1.00519134
65MP0003252_abnormal_bile_duct1.00016027
66MP0002735_abnormal_chemical_nociception0.99376664
67MP0005167_abnormal_blood-brain_barrier0.99150503
68MP0005394_taste/olfaction_phenotype0.99095781
69MP0005499_abnormal_olfactory_system0.99095781
70MP0001486_abnormal_startle_reflex0.96929378
71MP0001984_abnormal_olfaction0.96739323
72MP0002277_abnormal_respiratory_mucosa0.95896846
73MP0001324_abnormal_eye_pigmentation0.94591368
74MP0002572_abnormal_emotion/affect_behav0.91557709
75MP0002234_abnormal_pharynx_morphology0.91266472
76MP0001764_abnormal_homeostasis0.90793955
77MP0008058_abnormal_DNA_repair0.89595739
78MP0005410_abnormal_fertilization0.88884445
79MP0005377_hearing/vestibular/ear_phenot0.88348327
80MP0003878_abnormal_ear_physiology0.88348327
81MP0002148_abnormal_hypersensitivity_rea0.87840905
82MP0001529_abnormal_vocalization0.87186280
83MP0009764_decreased_sensitivity_to0.84927832
84MP0002653_abnormal_ependyma_morphology0.84588136
85MP0000230_abnormal_systemic_arterial0.84579970
86MP0002282_abnormal_trachea_morphology0.83201096
87MP0001929_abnormal_gametogenesis0.83039261
88MP0001119_abnormal_female_reproductive0.81688298
89MP0001873_stomach_inflammation0.80884260
90MP0001145_abnormal_male_reproductive0.80341061
91MP0000653_abnormal_sex_gland0.80074189
92MP0005195_abnormal_posterior_eye0.79071447
93MP0001440_abnormal_grooming_behavior0.78592922
94MP0005636_abnormal_mineral_homeostasis0.78447894
95MP0001293_anophthalmia0.78086760
96MP0003724_increased_susceptibility_to0.77525409
97MP0002928_abnormal_bile_duct0.76903107
98MP0003283_abnormal_digestive_organ0.75849640
99MP0001970_abnormal_pain_threshold0.74962211
100MP0001790_abnormal_immune_system0.74496006

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.40704860
2Abnormality of alanine metabolism (HP:0010916)4.40704860
3Hyperalaninemia (HP:0003348)4.40704860
4Acute necrotizing encephalopathy (HP:0006965)4.10070205
5Abnormality of the labia minora (HP:0012880)3.71811936
6Acute encephalopathy (HP:0006846)3.60789634
7Mitochondrial inheritance (HP:0001427)3.58457909
8Molar tooth sign on MRI (HP:0002419)3.52852090
9Abnormality of midbrain morphology (HP:0002418)3.52852090
10Abnormal mitochondria in muscle tissue (HP:0008316)3.48283068
11Congenital stationary night blindness (HP:0007642)3.46734512
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42689583
13Progressive macrocephaly (HP:0004481)3.40009568
14Decreased electroretinogram (ERG) amplitude (HP:0000654)3.39867491
15Abolished electroretinogram (ERG) (HP:0000550)3.36075311
16Abnormal rod and cone electroretinograms (HP:0008323)3.24766664
17Increased CSF lactate (HP:0002490)3.20661576
18Constricted visual fields (HP:0001133)3.14311951
19Attenuation of retinal blood vessels (HP:0007843)3.00967806
20Optic disc pallor (HP:0000543)2.92795036
21Hepatocellular necrosis (HP:0001404)2.90412930
22IgG deficiency (HP:0004315)2.89229897
233-Methylglutaconic aciduria (HP:0003535)2.88366276
24Dyschromatopsia (HP:0007641)2.85216921
25Cerebral edema (HP:0002181)2.77687133
26Pigmentary retinal degeneration (HP:0001146)2.71357514
27Tubulointerstitial nephritis (HP:0001970)2.65071304
28Hepatic necrosis (HP:0002605)2.61396540
29Nephronophthisis (HP:0000090)2.61305405
30Pancreatic cysts (HP:0001737)2.54028877
31Increased hepatocellular lipid droplets (HP:0006565)2.53319992
32Methylmalonic acidemia (HP:0002912)2.53076258
33Hypomagnesemia (HP:0002917)2.52870399
34Decreased central vision (HP:0007663)2.51020538
35Congenital, generalized hypertrichosis (HP:0004540)2.45821246
36Increased serum lactate (HP:0002151)2.45255751
37Congenital sensorineural hearing impairment (HP:0008527)2.42623068
38Medial flaring of the eyebrow (HP:0010747)2.41014474
39Type II lissencephaly (HP:0007260)2.39823359
40Lipid accumulation in hepatocytes (HP:0006561)2.38250684
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37598149
42Lactic acidosis (HP:0003128)2.35894710
43Septo-optic dysplasia (HP:0100842)2.35717196
44Pancreatic fibrosis (HP:0100732)2.35102715
45Hyperglycinemia (HP:0002154)2.34711510
46Abnormality of magnesium homeostasis (HP:0004921)2.33335969
47Maternal diabetes (HP:0009800)2.27900127
48Large eyes (HP:0001090)2.26815032
49True hermaphroditism (HP:0010459)2.19000476
50Abnormality of serum amino acid levels (HP:0003112)2.18322242
51Methylmalonic aciduria (HP:0012120)2.17641518
52Abnormality of homocysteine metabolism (HP:0010919)2.14409806
53Homocystinuria (HP:0002156)2.14409806
54Pendular nystagmus (HP:0012043)2.13163569
55Lethargy (HP:0001254)2.11399333
56Renal cortical cysts (HP:0000803)2.10205684
57Abnormality of the prostate (HP:0008775)2.09988022
58Abnormality of the renal medulla (HP:0100957)2.09492841
59Absent thumb (HP:0009777)2.07337289
60Panhypogammaglobulinemia (HP:0003139)2.06489071
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.05995275
62Anencephaly (HP:0002323)2.05025287
63Birth length less than 3rd percentile (HP:0003561)2.00512767
64Abnormality of the renal cortex (HP:0011035)2.00232672
65Cerebellar dysplasia (HP:0007033)1.98808483
66Anorexia (HP:0002039)1.93242502
67Absent septum pellucidum (HP:0001331)1.92722909
68Tetany (HP:0001281)1.91140740
69Asplenia (HP:0001746)1.88249467
70Renal Fanconi syndrome (HP:0001994)1.88239328
71Stomatitis (HP:0010280)1.87864495
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85907097
73Adactyly (HP:0009776)1.85127353
74Sclerocornea (HP:0000647)1.84718840
75Hypoproteinemia (HP:0003075)1.83844662
76Lissencephaly (HP:0001339)1.80794587
77Hyperglycinuria (HP:0003108)1.78449611
78Severe combined immunodeficiency (HP:0004430)1.77798946
79Chronic sinusitis (HP:0011109)1.76842095
80Abnormality of cells of the erythroid lineage (HP:0012130)1.76358731
81Nephrogenic diabetes insipidus (HP:0009806)1.74726673
82Increased intramyocellular lipid droplets (HP:0012240)1.74382560
83Poor speech (HP:0002465)1.74248450
84Disproportionate short-trunk short stature (HP:0003521)1.73281538
85Abnormality of sulfur amino acid metabolism (HP:0004339)1.72864878
86Macrocytic anemia (HP:0001972)1.71880239
87Exertional dyspnea (HP:0002875)1.71570070
88Abnormality of glycine metabolism (HP:0010895)1.71487522
89Abnormality of serine family amino acid metabolism (HP:0010894)1.71487522
90Respiratory failure (HP:0002878)1.70727347
91Abnormality of B cell number (HP:0010975)1.70703492
92Metabolic acidosis (HP:0001942)1.69349375
93Cerebral hypomyelination (HP:0006808)1.69102764
94Growth hormone deficiency (HP:0000824)1.68243287
95Leukodystrophy (HP:0002415)1.65445350
96B lymphocytopenia (HP:0010976)1.65216892
97Rib fusion (HP:0000902)1.62604930
98Ketoacidosis (HP:0001993)1.62548881
99Supernumerary spleens (HP:0009799)1.62380803
100Hypoplasia of the radius (HP:0002984)1.61733983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.85709159
2TXK3.49916962
3WNK33.37273728
4MAP4K22.95064446
5ADRBK22.89888083
6WNK42.86894933
7PLK42.70383732
8VRK22.58206869
9NUAK12.56621388
10FRK2.25763161
11ZAK1.97253043
12MST41.94442928
13GRK11.91840440
14CDK191.91216127
15MAP3K121.80753989
16STK391.72720893
17TAF11.72132811
18BMPR1B1.71098777
19TLK11.69109023
20BMPR21.65026423
21ACVR1B1.60128927
22OXSR11.58096945
23CDK81.47961947
24VRK11.40626217
25TIE11.39040431
26EIF2AK31.38903315
27MAP4K11.35948801
28KIT1.22181398
29MKNK21.16844159
30BCKDK1.16199866
31PINK11.14605921
32DYRK21.13345904
33TSSK61.10526594
34PLK31.06474805
35MKNK11.04211480
36MUSK0.98364933
37TYRO30.92555538
38TNIK0.88827547
39NEK10.88304188
40CSF1R0.88164129
41KDR0.85839575
42GRK60.84618616
43STK160.84410239
44NTRK20.81289067
45SYK0.78208365
46TNK20.76207805
47BUB10.75372629
48ADRBK10.74399898
49NME10.74275093
50PLK20.73263251
51DAPK20.71948044
52PRKCG0.71562005
53FES0.71430407
54IKBKB0.70931078
55CDC70.70235956
56EPHB20.68563953
57TEC0.68454395
58NEK20.68208586
59CCNB10.64810682
60WEE10.64539247
61INSRR0.63996229
62IRAK40.63771918
63PRKCH0.58506164
64SGK4940.58463321
65SGK2230.58463321
66PRKCQ0.57849499
67EIF2AK20.56035446
68ITK0.55933734
69MAP3K40.55770023
70PLK10.54606441
71EIF2AK10.52274864
72ATR0.50608315
73PASK0.50397895
74ERBB30.50305460
75CSNK2A20.48680359
76DAPK10.48616097
77AURKB0.46953349
78CHEK20.46949870
79MATK0.45674350
80DAPK30.42393116
81PRKACA0.42036405
82FLT30.41654360
83PRKCI0.40636161
84CSNK2A10.40601197
85MARK10.40517151
86WNK10.40204898
87PNCK0.38775082
88LYN0.37878208
89CAMKK20.37538135
90CDK90.37515399
91GRK50.36651283
92OBSCN0.36377283
93IGF1R0.34936702
94CAMK2A0.33927503
95PHKG20.32851974
96PHKG10.32851974
97PRKCA0.32803871
98MINK10.31479053
99ALK0.31269754
100CDK70.31078531

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.72760144
2Oxidative phosphorylation_Homo sapiens_hsa001903.62050530
3Ribosome_Homo sapiens_hsa030103.29811033
4Parkinsons disease_Homo sapiens_hsa050122.84640970
5One carbon pool by folate_Homo sapiens_hsa006702.69929453
6RNA polymerase_Homo sapiens_hsa030202.44286438
7Protein export_Homo sapiens_hsa030602.34883118
8Asthma_Homo sapiens_hsa053102.18850084
9Mismatch repair_Homo sapiens_hsa034302.14205196
10Primary immunodeficiency_Homo sapiens_hsa053402.06364525
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.03737241
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00704645
13Homologous recombination_Homo sapiens_hsa034401.97233507
14RNA degradation_Homo sapiens_hsa030181.93548411
15Alzheimers disease_Homo sapiens_hsa050101.90320268
16Huntingtons disease_Homo sapiens_hsa050161.88966492
17Autoimmune thyroid disease_Homo sapiens_hsa053201.81239089
18DNA replication_Homo sapiens_hsa030301.77653722
19Linoleic acid metabolism_Homo sapiens_hsa005911.76221256
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73091687
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71206735
22Allograft rejection_Homo sapiens_hsa053301.70677242
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66220856
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65990003
25Cardiac muscle contraction_Homo sapiens_hsa042601.62812377
26Non-homologous end-joining_Homo sapiens_hsa034501.60639209
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.53748482
28Nucleotide excision repair_Homo sapiens_hsa034201.45445495
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45044883
30Basal transcription factors_Homo sapiens_hsa030221.40386969
31Sulfur relay system_Homo sapiens_hsa041221.39574514
32Phototransduction_Homo sapiens_hsa047441.38774268
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31692306
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27331728
35Nicotine addiction_Homo sapiens_hsa050331.24141016
36Type I diabetes mellitus_Homo sapiens_hsa049401.23695341
37Graft-versus-host disease_Homo sapiens_hsa053321.22662353
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22155720
39Collecting duct acid secretion_Homo sapiens_hsa049661.18278861
40Ether lipid metabolism_Homo sapiens_hsa005651.17954052
41RNA transport_Homo sapiens_hsa030131.14541566
42Base excision repair_Homo sapiens_hsa034101.12957872
43Caffeine metabolism_Homo sapiens_hsa002321.11419068
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08934102
45Nitrogen metabolism_Homo sapiens_hsa009101.08278249
46Spliceosome_Homo sapiens_hsa030401.04796505
47Peroxisome_Homo sapiens_hsa041460.98089133
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.97578455
49Fanconi anemia pathway_Homo sapiens_hsa034600.97451205
50Rheumatoid arthritis_Homo sapiens_hsa053230.95530356
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93195467
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91808483
53Arachidonic acid metabolism_Homo sapiens_hsa005900.89485988
54Purine metabolism_Homo sapiens_hsa002300.88862549
55Pyrimidine metabolism_Homo sapiens_hsa002400.87823505
56Antigen processing and presentation_Homo sapiens_hsa046120.87122926
57Folate biosynthesis_Homo sapiens_hsa007900.86750845
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86446496
59Propanoate metabolism_Homo sapiens_hsa006400.84411423
60Butanoate metabolism_Homo sapiens_hsa006500.76642190
61Morphine addiction_Homo sapiens_hsa050320.73986796
62Tryptophan metabolism_Homo sapiens_hsa003800.71835721
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71069555
64Selenocompound metabolism_Homo sapiens_hsa004500.69143445
65Chemical carcinogenesis_Homo sapiens_hsa052040.69066579
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67930463
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67066462
68Vitamin digestion and absorption_Homo sapiens_hsa049770.66766412
69Metabolic pathways_Homo sapiens_hsa011000.65546688
70Olfactory transduction_Homo sapiens_hsa047400.63890035
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63185452
72Retinol metabolism_Homo sapiens_hsa008300.62264999
73Fat digestion and absorption_Homo sapiens_hsa049750.60844417
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60622651
75GABAergic synapse_Homo sapiens_hsa047270.60501668
76Hematopoietic cell lineage_Homo sapiens_hsa046400.57136760
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56961528
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.56291772
79Glutamatergic synapse_Homo sapiens_hsa047240.54832623
80Sulfur metabolism_Homo sapiens_hsa009200.52290113
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49729435
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49248710
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48795069
84Taste transduction_Homo sapiens_hsa047420.43842286
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43085902
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40759750
87Regulation of autophagy_Homo sapiens_hsa041400.39132729
88Serotonergic synapse_Homo sapiens_hsa047260.38253965
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.37479454
90Vitamin B6 metabolism_Homo sapiens_hsa007500.34125011
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31983165
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31594319
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29078605
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.28456319
95Salivary secretion_Homo sapiens_hsa049700.28430223
96T cell receptor signaling pathway_Homo sapiens_hsa046600.26019307
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25261510
98Circadian entrainment_Homo sapiens_hsa047130.24781774
99mRNA surveillance pathway_Homo sapiens_hsa030150.23064838
100Systemic lupus erythematosus_Homo sapiens_hsa053220.22525054

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »