ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	microtubule depolymerization (GO:0007019)	5.27202897
2	kinetochore organization (GO:0051383)	4.46170923
3	kinetochore assembly (GO:0051382)	4.40264493
4	resolution of meiotic recombination intermediates (GO:0000712)	4.24652919
5	histone H2A acetylation (GO:0043968)	4.08360015
6	response to pheromone (GO:0019236)	3.95532767
7	microtubule polymerization or depolymerization (GO:0031109)	3.83747712
8	meiotic chromosome segregation (GO:0045132)	3.82333400
9	behavioral response to nicotine (GO:0035095)	3.76030657
10	protein polyglutamylation (GO:0018095)	3.75304932
11	nonmotile primary cilium assembly (GO:0035058)	3.69499915
12	protein K11-linked deubiquitination (GO:0035871)	3.67444133
13	DNA double-strand break processing (GO:0000729)	3.59148463
14	chromatin remodeling at centromere (GO:0031055)	3.58588302
15	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.57104814
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.56463234
17	postsynaptic membrane organization (GO:0001941)	3.56024642
18	detection of light stimulus involved in visual perception (GO:0050908)	3.55655042
19	detection of light stimulus involved in sensory perception (GO:0050962)	3.55655042
20	retinal cone cell development (GO:0046549)	3.54345676
21	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.53309984
22	synapsis (GO:0007129)	3.50447370
23	auditory receptor cell stereocilium organization (GO:0060088)	3.46421872
24	presynaptic membrane assembly (GO:0097105)	3.45959178
25	histone exchange (GO:0043486)	3.43427539
26	CENP-A containing nucleosome assembly (GO:0034080)	3.39489116
27	synaptic transmission, cholinergic (GO:0007271)	3.38682595
28	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.32064050
29	regulation of translation, ncRNA-mediated (GO:0045974)	3.32064050
30	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.32064050
31	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.29105714
32	DNA ligation (GO:0006266)	3.28982992
33	signal peptide processing (GO:0006465)	3.25663510
34	piRNA metabolic process (GO:0034587)	3.20223487
35	regulation of DNA endoreduplication (GO:0032875)	3.19330942
36	regulation of cilium movement (GO:0003352)	3.15077867
37	neuronal action potential propagation (GO:0019227)	3.12349494
38	ventricular cardiac muscle cell development (GO:0055015)	3.11159120
39	ketone body metabolic process (GO:1902224)	3.08594801
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.05293417
41	response to nitrosative stress (GO:0051409)	3.02832128
42	metaphase plate congression (GO:0051310)	3.02828582
43	cilium organization (GO:0044782)	2.99595999
44	cilium assembly (GO:0042384)	2.94727204
45	startle response (GO:0001964)	2.94313149
46	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.93630898
47	photoreceptor cell maintenance (GO:0045494)	2.91982332
48	C4-dicarboxylate transport (GO:0015740)	2.91758404
49	platelet dense granule organization (GO:0060155)	2.89234327
50	amino acid salvage (GO:0043102)	2.86310399
51	L-methionine salvage (GO:0071267)	2.86310399
52	L-methionine biosynthetic process (GO:0071265)	2.86310399
53	protein localization to kinetochore (GO:0034501)	2.83757538
54	cerebral cortex radially oriented cell migration (GO:0021799)	2.82092565
55	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.80128541
56	inner ear receptor stereocilium organization (GO:0060122)	2.78335557
57	righting reflex (GO:0060013)	2.78271648
58	replication fork processing (GO:0031297)	2.77754143
59	cAMP catabolic process (GO:0006198)	2.77647727
60	neural tube formation (GO:0001841)	2.76893951
61	regulation of centriole replication (GO:0046599)	2.76323155
62	presynaptic membrane organization (GO:0097090)	2.75404413
63	recombinational repair (GO:0000725)	2.74348462
64	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.74281085
65	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.73785201
66	transmission of nerve impulse (GO:0019226)	2.72516130
67	behavioral response to ethanol (GO:0048149)	2.70906908
68	neuron fate determination (GO:0048664)	2.70827726
69	left/right axis specification (GO:0070986)	2.70553069
70	mitotic G2/M transition checkpoint (GO:0044818)	2.70052321
71	double-strand break repair via homologous recombination (GO:0000724)	2.68641365
72	chromosome organization involved in meiosis (GO:0070192)	2.67628404
73	mitotic G2 DNA damage checkpoint (GO:0007095)	2.66803902
74	cilium morphogenesis (GO:0060271)	2.66760557
75	axoneme assembly (GO:0035082)	2.65699869
76	intraciliary transport (GO:0042073)	2.63108038
77	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.61473052
78	DNA methylation involved in gamete generation (GO:0043046)	2.60272944
79	short-chain fatty acid metabolic process (GO:0046459)	2.58359190
80	meiotic cell cycle (GO:0051321)	2.56274375
81	limb bud formation (GO:0060174)	2.56126162
82	methionine biosynthetic process (GO:0009086)	2.55505024
83	negative regulation of neurotransmitter transport (GO:0051589)	2.54828396
84	microtubule organizing center organization (GO:0031023)	2.53928094
85	tachykinin receptor signaling pathway (GO:0007217)	2.53512966
86	sister chromatid segregation (GO:0000819)	2.52980514
87	DNA integration (GO:0015074)	2.51541014
88	male meiosis (GO:0007140)	2.51008232
89	retinal rod cell development (GO:0046548)	2.50780813
90	centrosome organization (GO:0051297)	2.50740891
91	DNA replication-independent nucleosome assembly (GO:0006336)	2.50034057
92	DNA replication-independent nucleosome organization (GO:0034724)	2.50034057
93	cyclic nucleotide catabolic process (GO:0009214)	2.49897213
94	response to folic acid (GO:0051593)	2.49480605
95	protein prenylation (GO:0018342)	2.48494111
96	prenylation (GO:0097354)	2.48494111
97	male meiosis I (GO:0007141)	2.48179974
98	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.47890527
99	epithelial cilium movement (GO:0003351)	2.44946789
100	thalamus development (GO:0021794)	2.43814345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.08011400
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.06240076
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.94541439
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.93197348
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.89119827
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.86146024
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81200106
8	VDR_22108803_ChIP-Seq_LS180_Human	2.76117129
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.57145474
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51513671
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50472289
12	FUS_26573619_Chip-Seq_HEK293_Human	2.49398838
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41562292
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.34153040
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.30471085
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29237027
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.23703487
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.22383027
19	EWS_26573619_Chip-Seq_HEK293_Human	2.20962209
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18381033
21	P300_19829295_ChIP-Seq_ESCs_Human	2.16304993
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13996316
23	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.08400363
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00655510
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98347842
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.95698168
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.94097870
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.76426729
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73298191
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.71131432
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.70695058
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70695058
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69430045
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.68963400
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63393526
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60066672
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.60003098
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58783015
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57233273
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56547436
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55869568
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.54351205
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51403753
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50426786
45	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49643129
46	STAT3_23295773_ChIP-Seq_U87_Human	1.49571386
47	AR_25329375_ChIP-Seq_VCAP_Human	1.48085610
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44404279
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44296011
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43851803
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43819495
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43036879
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.42511406
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41907132
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41381145
56	TCF4_23295773_ChIP-Seq_U87_Human	1.41242628
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.38440189
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37844846
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.34112182
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34112182
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.33725675
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.29765690
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28032532
64	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.25114631
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23726825
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22382418
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.21649389
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21321767
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18730905
70	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17934053
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16195673
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15704425
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.13977869
74	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.13195644
75	SOX9_26525672_Chip-Seq_HEART_Mouse	1.12191296
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11162492
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09636869
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09454845
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08719636
80	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.08604570
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06020988
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05733232
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05465365
84	JUN_21703547_ChIP-Seq_K562_Human	1.05114427
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05091404
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04782182
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03539348
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03333657
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02300987
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01391746
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99997462
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99855633
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99855633
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99740705
95	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.97399526
96	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.97341497
97	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.97341497
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97102551
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96174664
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93435557

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.33036861
2	MP0006292_abnormal_olfactory_placode	3.45659107
3	MP0000569_abnormal_digit_pigmentation	3.41154968
4	MP0008789_abnormal_olfactory_epithelium	2.87440333
5	MP0008877_abnormal_DNA_methylation	2.60963427
6	MP0002736_abnormal_nociception_after	2.60867262
7	MP0005646_abnormal_pituitary_gland	2.38134909
8	MP0000372_irregular_coat_pigmentation	2.27714059
9	MP0005499_abnormal_olfactory_system	2.25271639
10	MP0005394_taste/olfaction_phenotype	2.25271639
11	MP0005187_abnormal_penis_morphology	2.16883218
12	MP0005377_hearing/vestibular/ear_phenot	2.08178740
13	MP0003878_abnormal_ear_physiology	2.08178740
14	MP0005171_absent_coat_pigmentation	2.07463728
15	MP0009046_muscle_twitch	2.05373102
16	MP0001984_abnormal_olfaction	2.02078402
17	MP0005551_abnormal_eye_electrophysiolog	2.01861934
18	MP0001486_abnormal_startle_reflex	1.99691922
19	MP0003136_yellow_coat_color	1.96202409
20	MP0002653_abnormal_ependyma_morphology	1.94023737
21	MP0002938_white_spotting	1.81460673
22	MP0003693_abnormal_embryo_hatching	1.81027525
23	MP0003880_abnormal_central_pattern	1.77206129
24	MP0010030_abnormal_orbit_morphology	1.74039022
25	MP0010094_abnormal_chromosome_stability	1.73861877
26	MP0001968_abnormal_touch/_nociception	1.70977332
27	MP0000566_synostosis	1.69646843
28	MP0005408_hypopigmentation	1.67391256
29	MP0000647_abnormal_sebaceous_gland	1.62500476
30	MP0001293_anophthalmia	1.61136726
31	MP0000631_abnormal_neuroendocrine_gland	1.57307609
32	MP0004885_abnormal_endolymph	1.55221422
33	MP0002234_abnormal_pharynx_morphology	1.54613489
34	MP0002233_abnormal_nose_morphology	1.53903395
35	MP0001485_abnormal_pinna_reflex	1.53538258
36	MP0001529_abnormal_vocalization	1.53502490
37	MP0005248_abnormal_Harderian_gland	1.53142656
38	MP0004742_abnormal_vestibular_system	1.52505743
39	MP0000049_abnormal_middle_ear	1.52164131
40	MP0002638_abnormal_pupillary_reflex	1.50954151
41	MP0008058_abnormal_DNA_repair	1.49403127
42	MP0002095_abnormal_skin_pigmentation	1.46364106
43	MP0002822_catalepsy	1.44158461
44	MP0002272_abnormal_nervous_system	1.41663890
45	MP0005253_abnormal_eye_physiology	1.40178503
46	MP0003567_abnormal_fetal_cardiomyocyte	1.32662011
47	MP0000778_abnormal_nervous_system	1.32404107
48	MP0003938_abnormal_ear_development	1.31812322
49	MP0005075_abnormal_melanosome_morpholog	1.30515601
50	MP0003315_abnormal_perineum_morphology	1.26984505
51	MP0006054_spinal_hemorrhage	1.24255159
52	MP0003718_maternal_effect	1.21029168
53	MP0001324_abnormal_eye_pigmentation	1.18416723
54	MP0005391_vision/eye_phenotype	1.17148179
55	MP0003787_abnormal_imprinting	1.16295477
56	MP0006276_abnormal_autonomic_nervous	1.15287605
57	MP0009745_abnormal_behavioral_response	1.12948814
58	MP0002210_abnormal_sex_determination	1.11522032
59	MP0003755_abnormal_palate_morphology	1.11445881
60	MP0001929_abnormal_gametogenesis	1.10707467
61	MP0005195_abnormal_posterior_eye	1.08324701
62	MP0003121_genomic_imprinting	1.08035954
63	MP0002735_abnormal_chemical_nociception	1.06609746
64	MP0005386_behavior/neurological_phenoty	1.06113590
65	MP0004924_abnormal_behavior	1.06113590
66	MP0001986_abnormal_taste_sensitivity	1.04990624
67	MP0002752_abnormal_somatic_nervous	1.03567268
68	MP0000026_abnormal_inner_ear	1.03132865
69	MP0001919_abnormal_reproductive_system	1.02438621
70	MP0002064_seizures	1.02236851
71	MP0005174_abnormal_tail_pigmentation	1.01641049
72	MP0003646_muscle_fatigue	1.01086992
73	MP0003698_abnormal_male_reproductive	1.00541840
74	MP0000371_diluted_coat_color	0.99545975
75	MP0005367_renal/urinary_system_phenotyp	0.96694903
76	MP0000516_abnormal_urinary_system	0.96694903
77	MP0004142_abnormal_muscle_tone	0.96588412
78	MP0002067_abnormal_sensory_capabilities	0.95018111
79	MP0002557_abnormal_social/conspecific_i	0.94295463
80	MP0004133_heterotaxia	0.93820229
81	MP0004147_increased_porphyrin_level	0.92704570
82	MP0002837_dystrophic_cardiac_calcinosis	0.92539576
83	MP0000653_abnormal_sex_gland	0.92067411
84	MP0002184_abnormal_innervation	0.91883609
85	MP0006072_abnormal_retinal_apoptosis	0.91814560
86	MP0003937_abnormal_limbs/digits/tail_de	0.90772801
87	MP0004215_abnormal_myocardial_fiber	0.89232409
88	MP0001963_abnormal_hearing_physiology	0.88478446
89	MP0002572_abnormal_emotion/affect_behav	0.86211627
90	MP0000955_abnormal_spinal_cord	0.85262121
91	MP0000537_abnormal_urethra_morphology	0.84435977
92	MP0001145_abnormal_male_reproductive	0.84178242
93	MP0003385_abnormal_body_wall	0.82754321
94	MP0003077_abnormal_cell_cycle	0.82505938
95	MP0003122_maternal_imprinting	0.80453416
96	MP0003635_abnormal_synaptic_transmissio	0.79758342
97	MP0002092_abnormal_eye_morphology	0.77531713
98	MP0003137_abnormal_impulse_conducting	0.76736437
99	MP0005389_reproductive_system_phenotype	0.75374841
100	MP0002697_abnormal_eye_size	0.75267902

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	3.68011060
2	Molar tooth sign on MRI (HP:0002419)	3.68011060
3	Pancreatic cysts (HP:0001737)	3.66905026
4	True hermaphroditism (HP:0010459)	3.66874791
5	Hyperventilation (HP:0002883)	3.52726620
6	Pancreatic fibrosis (HP:0100732)	3.51940241
7	Volvulus (HP:0002580)	3.24434577
8	Abnormality of the labia minora (HP:0012880)	3.15468708
9	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.10969496
10	Gaze-evoked nystagmus (HP:0000640)	2.94771269
11	Nephronophthisis (HP:0000090)	2.89388668
12	Medial flaring of the eyebrow (HP:0010747)	2.74009887
13	Absent speech (HP:0001344)	2.73516333
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71518068
15	Gonadotropin excess (HP:0000837)	2.70144598
16	Pendular nystagmus (HP:0012043)	2.69497025
17	Intestinal atresia (HP:0011100)	2.64536645
18	Abnormality of the renal medulla (HP:0100957)	2.61628431
19	Abnormality of the ileum (HP:0001549)	2.60367951
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53758120
21	Long clavicles (HP:0000890)	2.53059993
22	Chromsome breakage (HP:0040012)	2.51321552
23	Anophthalmia (HP:0000528)	2.50936184
24	Meckel diverticulum (HP:0002245)	2.50827685
25	Abnormal lung lobation (HP:0002101)	2.49508898
26	Oligodactyly (HP:0012165)	2.46939713
27	Small hand (HP:0200055)	2.43789186
28	Cystic liver disease (HP:0006706)	2.41815311
29	Abnormality of the renal cortex (HP:0011035)	2.38674936
30	Astigmatism (HP:0000483)	2.37679194
31	Tented upper lip vermilion (HP:0010804)	2.36664509
32	Neoplasm of the adrenal cortex (HP:0100641)	2.35541330
33	Abnormality of macular pigmentation (HP:0008002)	2.34494026
34	Congenital stationary night blindness (HP:0007642)	2.33884047
35	Progressive cerebellar ataxia (HP:0002073)	2.33669818
36	Action tremor (HP:0002345)	2.32411605
37	Abnormality of chromosome stability (HP:0003220)	2.32214078
38	Postaxial foot polydactyly (HP:0001830)	2.31430654
39	Sloping forehead (HP:0000340)	2.29758332
40	Ectopic kidney (HP:0000086)	2.28553344
41	Methylmalonic acidemia (HP:0002912)	2.28139110
42	Renal hypoplasia (HP:0000089)	2.28061900
43	Tubular atrophy (HP:0000092)	2.27975917
44	Broad-based gait (HP:0002136)	2.27681976
45	Sclerocornea (HP:0000647)	2.24078900
46	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.20590371
47	Chronic hepatic failure (HP:0100626)	2.17648594
48	Abnormal biliary tract physiology (HP:0012439)	2.15572996
49	Bile duct proliferation (HP:0001408)	2.15572996
50	Tubulointerstitial fibrosis (HP:0005576)	2.15360538
51	Oligodactyly (hands) (HP:0001180)	2.13864582
52	Optic nerve hypoplasia (HP:0000609)	2.12529681
53	Postaxial hand polydactyly (HP:0001162)	2.11076266
54	Gait imbalance (HP:0002141)	2.11075156
55	Genital tract atresia (HP:0001827)	2.08831139
56	Congenital hepatic fibrosis (HP:0002612)	2.08794466
57	Abnormality of the preputium (HP:0100587)	2.07484753
58	Tubulointerstitial abnormality (HP:0001969)	2.06441514
59	Type II lissencephaly (HP:0007260)	2.06409245
60	Male pseudohermaphroditism (HP:0000037)	2.06353184
61	Congenital primary aphakia (HP:0007707)	2.04904682
62	Vaginal atresia (HP:0000148)	2.04803416
63	Focal motor seizures (HP:0011153)	2.04329098
64	Hyperglycinemia (HP:0002154)	2.03146789
65	Narrow forehead (HP:0000341)	2.02986725
66	Supernumerary spleens (HP:0009799)	2.02680047
67	Dysdiadochokinesis (HP:0002075)	1.99496425
68	Abnormal spermatogenesis (HP:0008669)	1.99248052
69	Short 1st metacarpal (HP:0010034)	1.96991881
70	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.96991881
71	Progressive macrocephaly (HP:0004481)	1.94827401
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94428397
73	Acute necrotizing encephalopathy (HP:0006965)	1.93890623
74	Preaxial hand polydactyly (HP:0001177)	1.93323319
75	Cupped ear (HP:0000378)	1.92470124
76	Growth hormone deficiency (HP:0000824)	1.90526101
77	Acute encephalopathy (HP:0006846)	1.90083103
78	Occipital encephalocele (HP:0002085)	1.89237127
79	Severe Myopia (HP:0011003)	1.88888332
80	Hypoplastic pelvis (HP:0008839)	1.88504230
81	Congenital sensorineural hearing impairment (HP:0008527)	1.87738319
82	Aganglionic megacolon (HP:0002251)	1.86706510
83	Duodenal stenosis (HP:0100867)	1.86509863
84	Small intestinal stenosis (HP:0012848)	1.86509863
85	Poor eye contact (HP:0000817)	1.86465018
86	Cerebellar dysplasia (HP:0007033)	1.86016611
87	Asplenia (HP:0001746)	1.83964137
88	Anencephaly (HP:0002323)	1.83642163
89	Clubbing of toes (HP:0100760)	1.83486356
90	Febrile seizures (HP:0002373)	1.82337138
91	Broad foot (HP:0001769)	1.81953856
92	Nephrogenic diabetes insipidus (HP:0009806)	1.81495443
93	Widely spaced teeth (HP:0000687)	1.79405475
94	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79303449
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79275797
96	Focal seizures (HP:0007359)	1.78494615
97	Abnormal drinking behavior (HP:0030082)	1.78416291
98	Polydipsia (HP:0001959)	1.78416291
99	Dandy-Walker malformation (HP:0001305)	1.77995082
100	Partial agenesis of the corpus callosum (HP:0001338)	1.77626775

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.58160383
2	WEE1	3.86222743
3	BRSK2	3.47900244
4	MAPK13	2.81911387
5	FRK	2.77973608
6	CASK	2.60628724
7	MKNK2	2.50980966
8	TNIK	2.45802333
9	PDK2	2.15389447
10	MARK3	2.05976201
11	MKNK1	1.91446831
12	CCNB1	1.89449668
13	WNK3	1.88759586
14	STK38L	1.79546252
15	EIF2AK3	1.77132271
16	NUAK1	1.72253497
17	ZAK	1.60247258
18	TRIM28	1.53921490
19	PLK2	1.52541151
20	BRSK1	1.46151711
21	BCR	1.45363823
22	NEK1	1.44669811
23	MAP3K4	1.44027128
24	PLK3	1.41891367
25	STK39	1.41089662
26	ERBB3	1.38358801
27	MARK1	1.36699850
28	DYRK2	1.32414464
29	WNK4	1.25374674
30	BUB1	1.23776409
31	PKN1	1.23288520
32	PINK1	1.22033455
33	MINK1	1.20567920
34	PLK4	1.19273505
35	GRK1	1.17352871
36	PLK1	1.09116380
37	INSRR	1.06747604
38	EPHA4	1.06107415
39	BMPR1B	1.04725953
40	MST4	1.04089963
41	EPHB2	1.01687263
42	SIK3	1.01162081
43	EIF2AK2	0.99314902
44	MAP2K7	0.93179138
45	UHMK1	0.87464854
46	TAF1	0.86685104
47	TNK2	0.83581603
48	CSNK1G1	0.80384606
49	TTK	0.78754219
50	ATR	0.78126773
51	PRKCG	0.78030633
52	NEK2	0.77356671
53	ADRBK2	0.76939408
54	OXSR1	0.75709162
55	BRD4	0.73193798
56	FGFR1	0.72348594
57	BMPR2	0.71988789
58	PTK2B	0.71854608
59	TIE1	0.69406971
60	DYRK1A	0.68767246
61	IRAK1	0.68528022
62	FER	0.66080251
63	CDC7	0.65862316
64	PRKCE	0.64781985
65	TLK1	0.64239532
66	AURKB	0.63097600
67	VRK1	0.61304819
68	KSR1	0.60919674
69	ADRBK1	0.59930835
70	KDR	0.58546972
71	AKT3	0.58183830
72	GRK5	0.58018029
73	CAMK2A	0.54976535
74	ATM	0.53780174
75	PAK3	0.49563951
76	PRKCZ	0.48033819
77	CHEK2	0.47957733
78	SGK2	0.45743518
79	PRKCI	0.45339630
80	TSSK6	0.41423102
81	RPS6KA5	0.40542187
82	ERBB2	0.39986800
83	MAPKAPK5	0.39703471
84	STK16	0.39534555
85	CDK7	0.39166746
86	DMPK	0.38841308
87	NTRK2	0.37999803
88	ROCK1	0.37868910
89	CSNK1D	0.37584826
90	NLK	0.37401056
91	OBSCN	0.35841372
92	CDK18	0.35428447
93	CSNK1G2	0.34217291
94	CSNK1A1	0.33883221
95	CHEK1	0.33857546
96	PRKACA	0.33383199
97	PRKCQ	0.33370292
98	CSNK2A1	0.33046080
99	DYRK3	0.32873687
100	PRKACB	0.31953074

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95713554
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.95463852
3	Homologous recombination_Homo sapiens_hsa03440	2.86844979
4	Nicotine addiction_Homo sapiens_hsa05033	2.63096055
5	Protein export_Homo sapiens_hsa03060	2.51888812
6	Propanoate metabolism_Homo sapiens_hsa00640	2.51645631
7	Phototransduction_Homo sapiens_hsa04744	2.23719283
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19749113
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.12610522
10	Butanoate metabolism_Homo sapiens_hsa00650	2.07423675
11	Non-homologous end-joining_Homo sapiens_hsa03450	1.99959314
12	Basal transcription factors_Homo sapiens_hsa03022	1.82257962
13	Proteasome_Homo sapiens_hsa03050	1.75614499
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72894535
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71496544
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.67072190
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.59666475
18	beta-Alanine metabolism_Homo sapiens_hsa00410	1.53543232
19	Parkinsons disease_Homo sapiens_hsa05012	1.53443741
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53394562
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.53337397
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.50442249
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45741264
24	Morphine addiction_Homo sapiens_hsa05032	1.45645933
25	Base excision repair_Homo sapiens_hsa03410	1.43537053
26	RNA degradation_Homo sapiens_hsa03018	1.42294236
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.37003835
28	Cell cycle_Homo sapiens_hsa04110	1.36772458
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.34373013
30	Olfactory transduction_Homo sapiens_hsa04740	1.32739240
31	Mismatch repair_Homo sapiens_hsa03430	1.30943874
32	p53 signaling pathway_Homo sapiens_hsa04115	1.29449032
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.25443615
34	Oocyte meiosis_Homo sapiens_hsa04114	1.23746543
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23710155
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.22569033
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15597720
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.13680091
39	Folate biosynthesis_Homo sapiens_hsa00790	1.12510607
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11040158
41	One carbon pool by folate_Homo sapiens_hsa00670	1.09463313
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.07528218
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07207043
44	Spliceosome_Homo sapiens_hsa03040	1.07142590
45	Huntingtons disease_Homo sapiens_hsa05016	1.05263326
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05210274
47	Circadian entrainment_Homo sapiens_hsa04713	1.05052020
48	Taste transduction_Homo sapiens_hsa04742	1.04698387
49	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01065758
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00787313
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00333024
52	GABAergic synapse_Homo sapiens_hsa04727	0.99116720
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.98907783
54	Dopaminergic synapse_Homo sapiens_hsa04728	0.96191413
55	Lysine degradation_Homo sapiens_hsa00310	0.93919065
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93744178
57	Caffeine metabolism_Homo sapiens_hsa00232	0.93725698
58	Amphetamine addiction_Homo sapiens_hsa05031	0.90581101
59	Regulation of autophagy_Homo sapiens_hsa04140	0.88930294
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84254058
61	DNA replication_Homo sapiens_hsa03030	0.82255569
62	RNA transport_Homo sapiens_hsa03013	0.80277643
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80086839
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79789715
65	Glutathione metabolism_Homo sapiens_hsa00480	0.76594246
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76105802
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.75669575
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74371485
69	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73560608
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71455147
71	Serotonergic synapse_Homo sapiens_hsa04726	0.69383715
72	Histidine metabolism_Homo sapiens_hsa00340	0.68622899
73	Purine metabolism_Homo sapiens_hsa00230	0.66184316
74	Fatty acid degradation_Homo sapiens_hsa00071	0.65374119
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.64150273
76	Alzheimers disease_Homo sapiens_hsa05010	0.63142819
77	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60386401
78	Fatty acid elongation_Homo sapiens_hsa00062	0.57611273
79	Salivary secretion_Homo sapiens_hsa04970	0.57289763
80	Metabolic pathways_Homo sapiens_hsa01100	0.56415659
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56385899
82	RNA polymerase_Homo sapiens_hsa03020	0.53712393
83	Retinol metabolism_Homo sapiens_hsa00830	0.51657376
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51151851
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.50829326
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50470531
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.50166153
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48125118
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47530397
90	Circadian rhythm_Homo sapiens_hsa04710	0.47318849
91	Cholinergic synapse_Homo sapiens_hsa04725	0.47143179
92	ABC transporters_Homo sapiens_hsa02010	0.45870820
93	Cocaine addiction_Homo sapiens_hsa05030	0.45601647
94	Mineral absorption_Homo sapiens_hsa04978	0.45392389
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44213602
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43785265
97	Hippo signaling pathway_Homo sapiens_hsa04390	0.43648039
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42762213
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42052085
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.39141868

HMGB1P41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »