ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of histone phosphorylation (GO:0033127)	6.94470179
2	behavioral response to nicotine (GO:0035095)	6.15398653
3	neuron remodeling (GO:0016322)	4.84694946
4	cytochrome complex assembly (GO:0017004)	4.75586596
5	respiratory chain complex IV assembly (GO:0008535)	4.48241979
6	replication fork processing (GO:0031297)	4.47119132
7	kynurenine metabolic process (GO:0070189)	4.27137395
8	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.99435756
9	interleukin-1-mediated signaling pathway (GO:0070498)	3.98668166
10	indolalkylamine metabolic process (GO:0006586)	3.95972081
11	indole-containing compound metabolic process (GO:0042430)	3.95821021
12	positive regulation of CREB transcription factor activity (GO:0032793)	3.82499093
13	synaptic transmission, cholinergic (GO:0007271)	3.81500195
14	serotonin metabolic process (GO:0042428)	3.73570535
15	pattern specification involved in kidney development (GO:0061004)	3.65465011
16	protein complex biogenesis (GO:0070271)	3.64443436
17	chaperone-mediated protein transport (GO:0072321)	3.63141488
18	histone-serine phosphorylation (GO:0035404)	3.58593099
19	aspartate family amino acid catabolic process (GO:0009068)	3.54544083
20	tryptophan metabolic process (GO:0006568)	3.51690291
21	primary amino compound metabolic process (GO:1901160)	3.46670810
22	regulation of cellular respiration (GO:0043457)	3.38894798
23	translesion synthesis (GO:0019985)	3.38812311
24	neuron fate determination (GO:0048664)	3.38711342
25	tryptophan catabolic process (GO:0006569)	3.33624907
26	indole-containing compound catabolic process (GO:0042436)	3.33624907
27	indolalkylamine catabolic process (GO:0046218)	3.33624907
28	spinal cord motor neuron differentiation (GO:0021522)	3.29878953
29	acrosome reaction (GO:0007340)	3.29407792
30	ribosomal small subunit assembly (GO:0000028)	3.28799391
31	tachykinin receptor signaling pathway (GO:0007217)	3.25525532
32	resolution of meiotic recombination intermediates (GO:0000712)	3.21078152
33	somite development (GO:0061053)	3.20782607
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20240245
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20240245
36	NADH dehydrogenase complex assembly (GO:0010257)	3.20240245
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20144512
38	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.17637132
39	ubiquinone biosynthetic process (GO:0006744)	3.15369845
40	opioid receptor signaling pathway (GO:0038003)	3.13461921
41	fucose catabolic process (GO:0019317)	3.12326557
42	L-fucose metabolic process (GO:0042354)	3.12326557
43	L-fucose catabolic process (GO:0042355)	3.12326557
44	sulfate transmembrane transport (GO:1902358)	3.09573130
45	DNA damage induced protein phosphorylation (GO:0006975)	3.08487895
46	lysine metabolic process (GO:0006553)	3.08431678
47	lysine catabolic process (GO:0006554)	3.08431678
48	head development (GO:0060322)	3.07599073
49	ribosomal small subunit biogenesis (GO:0042274)	3.07403670
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.06798159
51	hyperosmotic response (GO:0006972)	3.05905031
52	response to pheromone (GO:0019236)	25.0760757
53	cell proliferation in forebrain (GO:0021846)	2.97234559
54	positive regulation of activated T cell proliferation (GO:0042104)	2.95254757
55	viral transcription (GO:0019083)	2.89442807
56	left/right axis specification (GO:0070986)	2.87347696
57	sulfation (GO:0051923)	2.86310203
58	DNA deamination (GO:0045006)	2.85231626
59	nonmotile primary cilium assembly (GO:0035058)	2.83457698
60	axon ensheathment in central nervous system (GO:0032291)	2.82214041
61	central nervous system myelination (GO:0022010)	2.82214041
62	meiotic chromosome segregation (GO:0045132)	2.80157628
63	translational termination (GO:0006415)	2.80095727
64	sulfate transport (GO:0008272)	2.79992460
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.77515410
66	epithelial cilium movement (GO:0003351)	2.77117669
67	ubiquinone metabolic process (GO:0006743)	2.75303478
68	endoderm formation (GO:0001706)	2.75208249
69	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.75090784
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.74522314
71	quinone biosynthetic process (GO:1901663)	2.73410714
72	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.72969356
73	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.71426208
74	multicellular organism reproduction (GO:0032504)	2.70404443
75	cilium morphogenesis (GO:0060271)	2.67961313
76	cytoplasmic mRNA processing body assembly (GO:0033962)	2.67915329
77	tongue development (GO:0043586)	2.67810198
78	rRNA catabolic process (GO:0016075)	2.66237133
79	GTP biosynthetic process (GO:0006183)	2.62751216
80	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.61554394
81	transmission of nerve impulse (GO:0019226)	2.60282105
82	lateral ventricle development (GO:0021670)	2.58980623
83	UTP biosynthetic process (GO:0006228)	2.57767135
84	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.57060586
85	spliceosomal complex assembly (GO:0000245)	2.56110602
86	recombinational repair (GO:0000725)	2.55444619
87	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.54348151
88	regulation of translation, ncRNA-mediated (GO:0045974)	2.54348151
89	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.54348151
90	regulation of Rac GTPase activity (GO:0032314)	2.53373957
91	cotranslational protein targeting to membrane (GO:0006613)	2.52887177
92	protein targeting to ER (GO:0045047)	2.50453240
93	otic vesicle formation (GO:0030916)	2.49503700
94	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.49451674
95	pericardium development (GO:0060039)	2.49369463
96	maturation of SSU-rRNA (GO:0030490)	2.47762992
97	meiotic cell cycle (GO:0051321)	2.46563846
98	double-strand break repair via homologous recombination (GO:0000724)	2.46068643
99	postreplication repair (GO:0006301)	2.45514223
100	male meiosis I (GO:0007141)	2.45489146

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.31235138
2	ZNF274_21170338_ChIP-Seq_K562_Hela	6.14907057
3	VDR_22108803_ChIP-Seq_LS180_Human	2.65097941
4	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.50262036
5	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.31158548
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23701994
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20314210
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.17758906
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.98038181
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88122903
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.84244031
12	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.81940267
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.81659272
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79756587
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.75910829
16	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.75190089
17	NCOR_22424771_ChIP-Seq_293T_Human	1.72476108
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68811760
19	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.63874789
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.62663394
21	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.61086327
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.60802316
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.60102082
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.55880290
25	ERA_21632823_ChIP-Seq_H3396_Human	1.54477305
26	RAC3_21632823_ChIP-Seq_H3396_Human	1.49552362
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49023134
28	AR_25329375_ChIP-Seq_VCAP_Human	1.48092976
29	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.47309761
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45514554
31	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45514554
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45380691
33	P53_21459846_ChIP-Seq_SAOS-2_Human	1.43187315
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41271299
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36930323
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35075028
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35075028
38	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.34997222
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.32927317
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30140008
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.29254040
42	EWS_26573619_Chip-Seq_HEK293_Human	1.28892563
43	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26244570
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.24638876
45	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24217260
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22602188
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.22602188
48	P300_19829295_ChIP-Seq_ESCs_Human	1.21422169
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.21352367
50	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.21235249
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20483057
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18760379
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18517237
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.18161244
55	AR_20517297_ChIP-Seq_VCAP_Human	1.17226022
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16409074
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.15714884
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.15411548
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14699163
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13895581
61	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.12712466
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12644964
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12368186
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11937175
65	GBX2_23144817_ChIP-Seq_PC3_Human	1.11469623
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10037193
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09763520
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09402778
69	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09106258
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08030930
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.06799065
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.06764727
73	BCAT_22108803_ChIP-Seq_LS180_Human	1.06735786
74	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05888610
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05765170
76	E2F1_20622854_ChIP-Seq_HELA_Human	1.05124510
77	STAT3_23295773_ChIP-Seq_U87_Human	1.03668640
78	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02504436
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00199360
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00199360
81	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.00053233
82	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.99117048
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98922999
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98300239
85	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97302541
86	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.97125893
87	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96205827
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96044629
89	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90773966
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90747655
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.90491429
92	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.90401437
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.90080001
94	DROSHA_22980978_ChIP-Seq_HELA_Human	0.89718320
95	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.89497174
96	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87356228
97	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.86653316
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.86446953
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.86361566
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85682314

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.08403584
2	MP0009379_abnormal_foot_pigmentation	3.76664591
3	MP0003136_yellow_coat_color	3.00870009
4	MP0002653_abnormal_ependyma_morphology	2.94068357
5	MP0003646_muscle_fatigue	2.93075628
6	MP0008872_abnormal_physiological_respon	2.72859241
7	MP0004043_abnormal_pH_regulation	2.48678950
8	MP0008877_abnormal_DNA_methylation	2.44069539
9	MP0004147_increased_porphyrin_level	2.22753242
10	MP0002938_white_spotting	2.07521941
11	MP0006072_abnormal_retinal_apoptosis	2.02961189
12	MP0002234_abnormal_pharynx_morphology	1.98022892
13	MP0004142_abnormal_muscle_tone	1.94439028
14	MP0001485_abnormal_pinna_reflex	1.94036429
15	MP0003787_abnormal_imprinting	1.86121680
16	MP0004145_abnormal_muscle_electrophysio	1.85954832
17	MP0005551_abnormal_eye_electrophysiolog	1.85832661
18	MP0008789_abnormal_olfactory_epithelium	1.79795666
19	MP0009745_abnormal_behavioral_response	1.76031511
20	MP0009046_muscle_twitch	1.70703910
21	MP0005499_abnormal_olfactory_system	1.61767523
22	MP0005394_taste/olfaction_phenotype	1.61767523
23	MP0003693_abnormal_embryo_hatching	1.58572055
24	MP0002876_abnormal_thyroid_physiology	1.55907808
25	MP0003879_abnormal_hair_cell	1.55462834
26	MP0002277_abnormal_respiratory_mucosa	1.55137712
27	MP0001919_abnormal_reproductive_system	1.53244867
28	MP0010030_abnormal_orbit_morphology	1.52861788
29	MP0002102_abnormal_ear_morphology	1.52023098
30	MP0001293_anophthalmia	1.51935914
31	MP0001968_abnormal_touch/_nociception	1.50405538
32	MP0002638_abnormal_pupillary_reflex	1.49589628
33	MP0003806_abnormal_nucleotide_metabolis	1.49404876
34	MP0005360_urolithiasis	1.44275747
35	MP0005377_hearing/vestibular/ear_phenot	1.43828505
36	MP0003878_abnormal_ear_physiology	1.43828505
37	MP0005389_reproductive_system_phenotype	1.42048255
38	MP0000778_abnormal_nervous_system	1.41215637
39	MP0004742_abnormal_vestibular_system	1.39944939
40	MP0005084_abnormal_gallbladder_morpholo	1.37408979
41	MP0005195_abnormal_posterior_eye	1.36166749
42	MP0002928_abnormal_bile_duct	1.32432284
43	MP0000631_abnormal_neuroendocrine_gland	1.30512575
44	MP0003880_abnormal_central_pattern	1.29579888
45	MP0002184_abnormal_innervation	1.29265681
46	MP0000383_abnormal_hair_follicle	1.27891121
47	MP0002572_abnormal_emotion/affect_behav	1.26133758
48	MP0002064_seizures	1.25971363
49	MP0003252_abnormal_bile_duct	1.23630893
50	MP0005410_abnormal_fertilization	1.22739503
51	MP0002063_abnormal_learning/memory/cond	1.21074216
52	MP0003195_calcinosis	1.19423427
53	MP0001286_abnormal_eye_development	1.18012324
54	MP0003011_delayed_dark_adaptation	1.15808170
55	MP0000049_abnormal_middle_ear	1.15762703
56	MP0008875_abnormal_xenobiotic_pharmacok	1.13895952
57	MP0002272_abnormal_nervous_system	1.09700192
58	MP0000566_synostosis	1.09564037
59	MP0001324_abnormal_eye_pigmentation	1.09211793
60	MP0003635_abnormal_synaptic_transmissio	1.08948783
61	MP0005253_abnormal_eye_physiology	1.08550023
62	MP0002752_abnormal_somatic_nervous	1.07923638
63	MP0002735_abnormal_chemical_nociception	1.07606223
64	MP0002067_abnormal_sensory_capabilities	1.06589782
65	MP0004215_abnormal_myocardial_fiber	1.06088740
66	MP0002160_abnormal_reproductive_system	1.02664873
67	MP0005391_vision/eye_phenotype	1.02405359
68	MP0003632_abnormal_nervous_system	1.01809553
69	MP0005332_abnormal_amino_acid	0.99898627
70	MP0001970_abnormal_pain_threshold	0.98719599
71	MP0002733_abnormal_thermal_nociception	0.96612252
72	MP0005646_abnormal_pituitary_gland	0.95987689
73	MP0000955_abnormal_spinal_cord	0.95652344
74	MP0003567_abnormal_fetal_cardiomyocyte	0.94622041
75	MP0005174_abnormal_tail_pigmentation	0.93372469
76	MP0002736_abnormal_nociception_after	0.92048159
77	MP0001986_abnormal_taste_sensitivity	0.91156968
78	MP0004885_abnormal_endolymph	0.91117940
79	MP0004133_heterotaxia	0.90419274
80	MP0002152_abnormal_brain_morphology	0.89961300
81	MP0002210_abnormal_sex_determination	0.89709888
82	MP0001663_abnormal_digestive_system	0.89333513
83	MP0003755_abnormal_palate_morphology	0.89213216
84	MP0003119_abnormal_digestive_system	0.89116092
85	MP0000026_abnormal_inner_ear	0.89033039
86	MP0002882_abnormal_neuron_morphology	0.86722417
87	MP0000427_abnormal_hair_cycle	0.86454613
88	MP0005636_abnormal_mineral_homeostasis	0.86231889
89	MP0003890_abnormal_embryonic-extraembry	0.84752179
90	MP0002163_abnormal_gland_morphology	0.84197108
91	MP0001929_abnormal_gametogenesis	0.83255312
92	MP0002233_abnormal_nose_morphology	0.82545897
93	MP0001905_abnormal_dopamine_level	0.81658599
94	MP0002557_abnormal_social/conspecific_i	0.79319838
95	MP0000230_abnormal_systemic_arterial	0.78387797
96	MP0010678_abnormal_skin_adnexa	0.78197370
97	MP0002092_abnormal_eye_morphology	0.77883372
98	MP0001765_abnormal_ion_homeostasis	0.71835449
99	MP0002282_abnormal_trachea_morphology	0.71660967
100	MP0001984_abnormal_olfaction	0.70964796

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.06058889
2	Molar tooth sign on MRI (HP:0002419)	4.06058889
3	Congenital stationary night blindness (HP:0007642)	3.99471847
4	Birth length less than 3rd percentile (HP:0003561)	3.71591401
5	Microretrognathia (HP:0000308)	3.62604763
6	True hermaphroditism (HP:0010459)	3.61149657
7	Reticulocytopenia (HP:0001896)	3.19106006
8	Pancreatic fibrosis (HP:0100732)	3.12411797
9	Pancreatic cysts (HP:0001737)	3.09466689
10	Papilledema (HP:0001085)	2.90363795
11	Pheochromocytoma (HP:0002666)	2.87355909
12	Breast hypoplasia (HP:0003187)	2.83743117
13	Nephronophthisis (HP:0000090)	2.82277380
14	Abnormal drinking behavior (HP:0030082)	2.80999096
15	Polydipsia (HP:0001959)	2.80999096
16	Septo-optic dysplasia (HP:0100842)	2.73695339
17	Abnormality of secondary sexual hair (HP:0009888)	2.66674471
18	Abnormality of the axillary hair (HP:0100134)	2.66674471
19	Meningioma (HP:0002858)	2.62454843
20	Neoplasm of head and neck (HP:0012288)	2.61159407
21	Esophageal neoplasm (HP:0100751)	2.61159407
22	Abnormality of the vertebral endplates (HP:0005106)	2.60008438
23	Conjunctival hamartoma (HP:0100780)	2.59760265
24	Cystic liver disease (HP:0006706)	2.56869929
25	Bone cyst (HP:0012062)	2.53519012
26	Hyperglycinemia (HP:0002154)	2.51590287
27	Neuroendocrine neoplasm (HP:0100634)	2.51056336
28	Acute encephalopathy (HP:0006846)	2.47818285
29	Abnormality of the renal medulla (HP:0100957)	2.47360645
30	Irregular vertebral endplates (HP:0003301)	2.45159320
31	Short 4th metacarpal (HP:0010044)	2.44994264
32	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.44994264
33	Acute necrotizing encephalopathy (HP:0006965)	2.42123931
34	Abnormal number of incisors (HP:0011064)	2.40202840
35	Furrowed tongue (HP:0000221)	2.35666357
36	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.34725768
37	Abnormality of lateral ventricle (HP:0030047)	2.33197841
38	Genetic anticipation (HP:0003743)	2.32410804
39	Hypomagnesemia (HP:0002917)	2.30307501
40	Partial agenesis of the corpus callosum (HP:0001338)	2.29585476
41	Increased serum pyruvate (HP:0003542)	2.29235729
42	Absent thumb (HP:0009777)	2.26261369
43	Abnormal mitochondria in muscle tissue (HP:0008316)	2.23512127
44	Polyuria (HP:0000103)	2.22455652
45	Sclerocornea (HP:0000647)	2.21911856
46	Tinnitus (HP:0000360)	2.21182076
47	Pendular nystagmus (HP:0012043)	2.20606573
48	Hip contracture (HP:0003273)	2.19154267
49	Abnormality of the diencephalon (HP:0010662)	2.17727163
50	Abnormality of magnesium homeostasis (HP:0004921)	2.16327880
51	Increased CSF lactate (HP:0002490)	2.15863824
52	Hepatocellular necrosis (HP:0001404)	2.14929442
53	Anencephaly (HP:0002323)	2.11454117
54	Abnormality of cells of the erythroid lineage (HP:0012130)	2.10166917
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10158396
56	Abnormality of alanine metabolism (HP:0010916)	2.10158396
57	Hyperalaninemia (HP:0003348)	2.10158396
58	Patellar aplasia (HP:0006443)	2.09994394
59	Absent/shortened dynein arms (HP:0200106)	2.09935184
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09935184
61	Progressive cerebellar ataxia (HP:0002073)	2.09760910
62	Mitochondrial inheritance (HP:0001427)	2.09545790
63	Hepatic necrosis (HP:0002605)	2.08700654
64	Gait imbalance (HP:0002141)	2.07365388
65	Optic nerve hypoplasia (HP:0000609)	2.06392255
66	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.05380209
67	Abnormality of the 4th metacarpal (HP:0010012)	2.05156592
68	Abnormality of the renal cortex (HP:0011035)	2.03464318
69	Medial flaring of the eyebrow (HP:0010747)	2.03172251
70	Abnormality of the carotid arteries (HP:0005344)	2.01213212
71	Abnormal ciliary motility (HP:0012262)	2.00995579
72	Hamartoma of the eye (HP:0010568)	2.00470816
73	Rib fusion (HP:0000902)	1.98112905
74	Aplasia/Hypoplasia of the patella (HP:0006498)	1.96920989
75	Macrocytic anemia (HP:0001972)	1.96652668
76	Abnormal biliary tract physiology (HP:0012439)	1.95674479
77	Bile duct proliferation (HP:0001408)	1.95674479
78	Delayed CNS myelination (HP:0002188)	1.95359610
79	Broad distal phalanx of finger (HP:0009836)	1.93989205
80	Anophthalmia (HP:0000528)	1.91908616
81	Occipital encephalocele (HP:0002085)	1.91814068
82	Meckel diverticulum (HP:0002245)	1.91599291
83	Fibular hypoplasia (HP:0003038)	1.91409549
84	11 pairs of ribs (HP:0000878)	1.90964935
85	Nephrogenic diabetes insipidus (HP:0009806)	1.90802534
86	Lissencephaly (HP:0001339)	1.90465767
87	Abolished electroretinogram (ERG) (HP:0000550)	1.89555352
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89205883
89	Abnormality of the ileum (HP:0001549)	1.89186035
90	Progressive inability to walk (HP:0002505)	1.88613369
91	Progressive macrocephaly (HP:0004481)	1.88234180
92	Absent septum pellucidum (HP:0001331)	1.86966653
93	Hypoplasia of the radius (HP:0002984)	1.86879937
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84248580
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.84248580
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84076113
97	Tubular atrophy (HP:0000092)	1.81223989
98	Neoplasm of the adrenal gland (HP:0100631)	1.80553057
99	Abnormal urine output (HP:0012590)	1.80424956
100	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.80319313

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.84241138
2	BMPR1B	5.73905382
3	WNK3	3.73123098
4	TLK1	2.95356633
5	TGFBR1	2.90568163
6	ADRBK2	2.82135741
7	TAOK3	2.68943496
8	EPHB2	2.55747733
9	WNK4	2.28374263
10	STK16	2.12713421
11	MAPK13	1.98690472
12	CDC7	1.78281479
13	NUAK1	1.62925035
14	GRK1	1.59397165
15	ADRBK1	1.59154783
16	CDK8	1.57826324
17	FRK	1.56871935
18	MAP3K2	1.52271684
19	NTRK2	1.47291697
20	PIK3CA	1.47253930
21	OXSR1	1.27794280
22	MAP2K2	1.27609321
23	NEK2	1.27602004
24	BCKDK	1.22765121
25	PLK4	1.16152606
26	SIK2	1.09526468
27	DYRK2	1.08781354
28	DYRK1B	1.06570794
29	GRK7	1.04907441
30	STK39	1.02272653
31	LIMK1	1.01110432
32	TRPM7	1.00570185
33	MARK1	0.94427733
34	DAPK2	0.90442377
35	CAMK1D	0.88049559
36	PHKG2	0.87040178
37	PHKG1	0.87040178
38	CAMKK2	0.86748902
39	NTRK1	0.86163975
40	STK38L	0.85349725
41	PRKCQ	0.84345951
42	TRIM28	0.82805698
43	PKN1	0.80585819
44	CAMKK1	0.80351782
45	MAP4K2	0.79285118
46	MAP2K1	0.77571524
47	BRAF	0.77528010
48	RPS6KA6	0.76359395
49	MARK3	0.74110512
50	PDK2	0.72894342
51	CASK	0.71124194
52	MELK	0.70496453
53	PLK1	0.68037345
54	ZAK	0.65904891
55	PINK1	0.65422474
56	WEE1	0.64557692
57	CHEK2	0.62772014
58	PRKCG	0.58796014
59	MAPK15	0.55855767
60	EPHA4	0.55279998
61	PNCK	0.54854239
62	PTK2B	0.54266172
63	KSR2	0.53107942
64	RPS6KA5	0.51869507
65	FLT3	0.51796726
66	TAF1	0.51135911
67	AKT3	0.47275302
68	LRRK2	0.46756486
69	TYRO3	0.45779126
70	PLK3	0.45775564
71	MAP3K8	0.44255350
72	IRAK4	0.43541402
73	PRKCZ	0.40971181
74	BRSK2	0.40922462
75	MAP2K7	0.40594713
76	CAMK2A	0.40544100
77	ABL2	0.39899197
78	PRKCI	0.39780199
79	NME1	0.39607675
80	PLK2	0.39104859
81	MAP3K11	0.38466633
82	BRSK1	0.38143374
83	MAP3K4	0.37722521
84	MAPK12	0.37235972
85	PRKCH	0.36033881
86	UHMK1	0.35347070
87	STK3	0.35096980
88	CDK15	0.32971369
89	TIE1	0.32006386
90	INSRR	0.31465251
91	CDK14	0.30702440
92	CDK1	0.30508469
93	MST4	0.30161595
94	PRKAA1	0.27777540
95	CDK18	0.27040650
96	MAP2K4	0.26406272
97	PRKCA	0.26132775
98	DYRK1A	0.26100684
99	WNK1	0.25626714
100	CDK5	0.25371564

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.31496837
2	Homologous recombination_Homo sapiens_hsa03440	3.15253319
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.99789984
4	Ribosome_Homo sapiens_hsa03010	2.95160942
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.90706271
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.76802869
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.70606296
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.64932412
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.47220700
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.31338145
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.31113269
12	RNA polymerase_Homo sapiens_hsa03020	2.16093754
13	Parkinsons disease_Homo sapiens_hsa05012	2.15472946
14	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.07651256
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.95863401
16	Fat digestion and absorption_Homo sapiens_hsa04975	1.85536484
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.71149852
18	RNA degradation_Homo sapiens_hsa03018	1.70947508
19	Mismatch repair_Homo sapiens_hsa03430	1.59601006
20	Huntingtons disease_Homo sapiens_hsa05016	1.59558914
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54849186
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53822286
23	One carbon pool by folate_Homo sapiens_hsa00670	1.48671817
24	Alzheimers disease_Homo sapiens_hsa05010	1.43603283
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42496200
26	Bladder cancer_Homo sapiens_hsa05219	1.42223525
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42067925
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.39692408
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39021379
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38968687
31	Protein export_Homo sapiens_hsa03060	1.35853274
32	Butanoate metabolism_Homo sapiens_hsa00650	1.35555314
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.34331327
34	Phototransduction_Homo sapiens_hsa04744	1.21619155
35	Basal transcription factors_Homo sapiens_hsa03022	1.18158714
36	Asthma_Homo sapiens_hsa05310	1.17140183
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15741557
38	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.13208040
39	Propanoate metabolism_Homo sapiens_hsa00640	1.09290069
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.09107645
41	Olfactory transduction_Homo sapiens_hsa04740	1.07186996
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04621500
43	Circadian entrainment_Homo sapiens_hsa04713	1.02094096
44	Fatty acid degradation_Homo sapiens_hsa00071	0.99345455
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98240225
46	Sulfur relay system_Homo sapiens_hsa04122	0.97772965
47	Histidine metabolism_Homo sapiens_hsa00340	0.97761063
48	DNA replication_Homo sapiens_hsa03030	0.96385003
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.92765702
50	Nicotine addiction_Homo sapiens_hsa05033	0.88415235
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81166553
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80438961
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80205840
54	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.75552294
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73900062
56	Morphine addiction_Homo sapiens_hsa05032	0.73821141
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71789181
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71145081
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70736147
60	Insulin secretion_Homo sapiens_hsa04911	0.69514860
61	Peroxisome_Homo sapiens_hsa04146	0.67639162
62	Base excision repair_Homo sapiens_hsa03410	0.67284004
63	Purine metabolism_Homo sapiens_hsa00230	0.64288154
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61967443
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.61300091
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61234329
67	Mineral absorption_Homo sapiens_hsa04978	0.60988477
68	Folate biosynthesis_Homo sapiens_hsa00790	0.59772393
69	Caffeine metabolism_Homo sapiens_hsa00232	0.59233706
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.58139895
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57645502
72	Retinol metabolism_Homo sapiens_hsa00830	0.57645222
73	Serotonergic synapse_Homo sapiens_hsa04726	0.52022675
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52013336
75	Axon guidance_Homo sapiens_hsa04360	0.51962741
76	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50866862
77	Metabolic pathways_Homo sapiens_hsa01100	0.50725811
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.50242334
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49392974
80	Lysine degradation_Homo sapiens_hsa00310	0.49121365
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47221547
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46093045
83	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45994129
84	Long-term depression_Homo sapiens_hsa04730	0.44132414
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41711205
86	Pancreatic secretion_Homo sapiens_hsa04972	0.41662999
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41370168
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40423266
89	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.37035025
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.35965429
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33201541
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32667704
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30957451
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30548072
95	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.27718000
96	Bile secretion_Homo sapiens_hsa04976	0.27323378
97	Cell cycle_Homo sapiens_hsa04110	0.27215833
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.25399485
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25180784
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.24751954

HMGB1P44

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »